USPTO Patents Application 10033246

WORLD INTELLECTUAL PROPERTY ORGANIZATION
International Bureau

PCT

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)

(51) International Patent Classification ° :

C12N 15/12, C07K 14/47, A61K 38/17,
C12N 5/10, C12Q 1/68

A2

(11) International Publication Number:
(43) International Publication Date:

WO 98/45437

15 October 1998 (15.10.98)

(21) International Application Number: PCT/US 9 8/06956

(22) International Filing Date: 10 April 1998 (10.0498)

(30) Priority Data:

08/837,312

10 April 1997 (10.04.97)

US

(71) Applicant: GENETICS INSTITUTE, INC. [US/US]; 87 Cam-

bridgePark Drive, Cambridge, MA 02140 (US).

(72) Inventors: JACOBS, Kenneth; 151 Beaumont Avenue, New-

ton, MA 02160 (US). MCCOY, John, M.; 56 Howard
Street, Reading, MA 01867 (US). LAVALLIE, Edward,
R.; 113 Ann Lee Road, Harvard, MA 01451 (US). RACIE,
Lisa, A.; 124 School Street, Acton, MA 01720 (US). MER-
BERG, David; 2 Orchard Drive, Acton, MA 01720 (US).
TREACY, Maurice; 93 Walcott Road, Chestnut Hill, MA
02167 (US). SPAULDING, Vikki; 11 Meadowbank Road,
Billerica, MA 01821 (US). AGOSTINO, Michael, J.; 26
Wolcott Avenue, Andover, MA 01810 (US).

(81) Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR,
BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE,
GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ,
LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW,
MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ,
TM, TR, TT, UA, UG, UZ, VN, YU, ZW, ARIPO patent
(GH, GM, KE, LS, MW, SD, SZ, UG, Z W), Eurasian patent
(AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European patent
(AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT,
LU, MC, NL, PT, SE), OAPI patent (BF, BJ, CF, CG, CI,
CM, GA, GN, ML, MR, NE, SN, TD, TG).

Published

Without international search report and to be republished
upon receipt of that report.

(74) Agent: SPRUNGER, Suzanne, A.; Genetics Institute, Inc., 87
CambridgePark Drive, Cambridge, MA 02140 (US).

(54) Title: SECRETED EXPRESSED SEQUENCE TAGS (sESTs)
(57) Abstract

Secreted expressed sequence tags (sESTs) isolated from a variety of human tissue sources are provided.

FOR THE PURPOSES OF INFORMATION ONLY
Codes used to identify States party to the PCT on the front pages of pamphlets publishing international applications under the PCT.

AL

Albania

ES

Spain

LS

Lesotho

SI

Slovenia

AM

Armenia

FI

Finland

LT

Lithuania

SK

Slovakia

AT

Austria

FR

France

LU

Luxembourg

SN

Senegal

AU

Australia

GA

Gabon

LV

Latvia

sz

Swaziland

AZ

Azerbaijan

GB

United Kingdom

MC

Monaco

TD

Chad

BA

Bosnia and Herzegovina

GE

Georgia

MD

Republic of Moldova

TG

Togo

BB

Barbados

GH

Ghana

MG

Madagascar

TJ

Tajikistan

BE

Belgium

GN

Guinea

MK

The former Yugoslav

TM

Turkmenistan

BF

Burkina Faso

GR

Greece

Republic of Macedonia

TR

Turkey

BG

Bulgaria

HU

Hungary

ML

Mali

TT

Trinidad and Tobago

BJ

Benin

IE

Ireland

MN

Mongolia

UA

Ukraine

BR

Brazil

IL

Israel

MR

Mauritania

UG

Uganda

BY

Belarus

IS

Iceland

MW

Malawi

US

United States of America

CA

Canada

IT

Italy

MX

Mexico

uz

Uzbekistan

CF

Central African Republic

JP

Japan

NE

Niger

VN

Viet Nam

CG

Congo

KE

Kenya

NL

Netherlands

YU

Yugoslavia

CH

Switzerland

KG

Kyrgyzstan

NO

Norway

zw

Zimbabwe

CI

Cdte d'lvoire

KP

Democratic People's

NZ

New Zealand

CM

Cameroon

Republic of Korea

PL

Poland

CN

China

KR

Republic of Korea

PT

Portugal

cu

Cuba

KZ

Kazakstan

RO

Romania

cz

Czech Republic

LC

Saint Lucia

RU

Russian Federation

DE

Germany

LI

Liechtenstein

SD

Sudan

DK

Denmark

LK

Sri Lanka

SE

Sweden

EE

Estonia

LR

Liberia

SG

Singapore

WO 98/45437 PCT/US98/06956

SECRETED EXPRESSED SEQUENCE TAGS (sESTs)

5 FIELD OF THE INVENTION

The present invention provides novel polynucleotides which are expressed sequence
tags (ESTs) for secreted proteins.

BACKGROUND OF THE INVENTION

10 Gargantuan efforts have been employed by various investigational projects to

randomly sequence portions of naturally-occurring cDNAs. The rationale behind this approach
to identification and sequencing genes is founded in two basic principles: (1) that transcribed
cDNAs represent the product of the most important genes, namely those that are actually
expressed in vivo, and (2) that efforts to sequence genes and other portions of the genome of

15 target organisms which are not actually expressed wastes substantial effort on areas not likely
to yield genetic information of therapeutic importance. Thus, the high-throughput sequencing
efforts focus on only those portions of the genome which are expressed. The randomly
produced cDNA sequences represent "expressed sequence tags" or "ESTs", which identify and
can be used as probes for the longer, full-length cDNA or genomic sequence from which they

2 0 were transcribed.

Although this "shortcut" approach to genomic sequencing presents savings of effort
compared to sequencing of the complete genome, it still produced a vast array of ESTs which
may not be directly useful as protein therapeutics. To date, the majority of protein-related drug
discovery has focused on the use of secreted proteins to produce a desired therapeutic effect.

2 5 Since the EST approach theoretically identifies all expressed proteins, it produces an EST

library which contains a mixture of secreted proteins (such as hormones, cytokines and
receptors) and non-secreted proteins (such as, for example, metabolic enzymes and cellular
structural proteins), without identifying which ESTs correspond to proteins falling into either
category. As a result, these methods are not optimally tailored to the needs of investigators

3 0 searching for secreted proteins because they must separate the secreted "wheat" from the non-

secreted "chaff', wasting effort and resources in the process.

Co-assigned U.S. Patent No. 5,536,637, which is incorporated herein by reference,
provides methods for focusing genomic sequencing efforts on sequences encoding the secreted
proteins which are of most interest for identification of protein therapeutics. The '637 patent
3 5 discloses a "signal sequence trap" which selectively identifies ESTs for secreted

WO 98/45437

PCT/US98/06956

proteins, namely "secreted expressed sequence tags" or "sESTs". It is to these sESTs that
the present invention is directed.

SUMMARY OF THE INVENTION
5 The present invention provides for sESTs isolated from a variety of human

RNA/cDNA sources.

In preferred embodiments, the present invention provides an isolated polynucleotide
comprising a nucleotide sequence selected from the group consisting of:

SEQ ID NO:l, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ

10 ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID

NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ
ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO:20, SEQ
ID NO:21 , SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ
ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ

15 ID NO:31 , SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ

ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO.40, SEQ
ID NO:41 , SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ
ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ
ID NO:5 1 , SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ

20 ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ

ID NO:61 , SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ
ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ
ID NO:71 , SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ
ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ

25 ID NO:81 , SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ

ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ
ID NO:91, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ
ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO: 100,
SEQ ID NO: 101, SEQ ID NO: 102, SEQ ID NO: 103, SEQ ID NO: 104, SEQ ID

3 0 NO: 105, SEQ ID NO: 106, SEQ ID NO: 107, SEQ ID NO: 108, SEQ ID NO: 109,

SEQ ID NO: 110, SEQ ID NO: 111, SEQ ID NO: 112, SEQ ID NO: 113, SEQ ID
NO: 1 14, SEQ ID NO: 115, SEQ ID NO: 1 16, SEQ ID NO: 117, SEQ ID NO: 1 18,
SEQ ID NO: 119, SEQ ID NO: 120, SEQ ID NO: 121, SEQ ID NO: 122, SEQ ID
NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 127,

2

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10

15

20

25

30

SEQID NO: 128, SEQ ID NO: 129, SEQ ID NO: 130, SEQ ID NO: 131, SEQ ID
NO: 132, SEQ ID NO: 133, SEQ ID NO: 134, SEQ ID NO: 135, SEQ ID NO: 136,
SEQID NO: 137, SEQ ID NO: 138, SEQ ID NO: 139. SEQ ID NO: 140, SEQ ID
NO: 141, SEQ ID NO: 142, SEQ ID NO: 143, SEQ ID NO: 144, SEQ ID NO: 145,
SEQ ID NO: 146, SEQ ID NO: 147, SEQ ID NO: 148, SEQ ID NO: 149, SEQ ID
NO:150, SEQ ID NO: 151, SEQ ID NO: 152, SEQ ID NO: 153, SEQ ID NO: 154,
SEQ ID NO:155, SEQ ID NO:156, SEQ ID NO:157, SEQ ID NO:158, SEQ ID
NO: 159, SEQID NO: 160, SEQ ID NO: 161, SEQ ID NO: 162, SEQ ID NO: 163,
SEQ ID NO: 164, SEQ ID NO: 165, SEQ ID NO: 166, SEQ ID NO: 167, SEQ ID
NO: 168, SEQ ID NO: 169, SEQ ID NO: 170, SEQ ID NO: 171, SEQ ID NO: 172,
SEQ ID NO: 173, SEQ ID NO: 174, SEQ ID NO: 175, SEQ ID NO: 176, SEQ ID
NO: 177, SEQ ID NO: 178, SEQ ID NO: 179, SEQ ID NO: 180, SEQ ID NO: 181,
SEQ ID NO:182, SEQ ID NO:183, SEQ ID NO:184, SEQ ID NO:185, SEQ ID
NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, SEQ ID NO: 189, SEQ ID NO: 190,
SEQ ID NO:I91, SEQ ID NO:192, SEQ ID NO:193, SEQ ID NO:194, SEQ ID
NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199,
SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID
NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208,
SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:211, SEQ ID NO:212, SEQ ID
NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217,
SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID
NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226,
SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID
NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235,
SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238 7 SEQ ID NO:239, SEQ ID
NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244,
SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:247, SEQ ID NO:248, SEQ ID
NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253,
SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID
NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:261, SEQ ID NO:262,
SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID
NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271,
SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275, SEQ ID
NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280,

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SEQ ID NO:281, SEQ ID NO;282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID
NO:285, SEQ ID NO:286, SEQ ID NO;287, SEQ ID NO:288, SEQ ID NO:289,
SEQ ID NO:290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID NO:293, SEQ ID
NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298,
5 SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO.30U SEQ ID NO:302, SEQ ID

NO:303, SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307,
SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:310, SEQ ID NO:311, SEQ ID
NO:312, SEQ ID NO:313, SEQ ID NO:314, SEQ ID NO:315, SEQ ID NO:316,
SEQ ID NO:317, SEQ ID NO:318, SEQ ID NO:319, SEQ ID NO:320, SEQ ID

10 NO:321, SEQ ID NO:322, SEQ ID NO:323 r SEQ ID NO;324, SEQ ID NO:325,

SEQ ID NO:326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID
NO:330, SEQ ID NO:331, SEQ ID NO;332, SEQ ID NO:333, SEQ ID NO:334,
SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO;337, SEQ ID NO:338, SEQ ID
NO:339, SEQ ID NO;340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO:343,

15 SEQ ID NO:344, SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID

NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352,
SEQ ID NO:353, SEQ ID NO:354 t SEQ ID NO:?55, SEQ ID NO;356, SEQ ID
NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO:360, SEQ ID NO:361,
SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID

2 0 NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369, SEQ ID NO:370,

SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373, SEQ ID NO:374, SEQ ID
NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379,
SEQ ID NO:380, SEQ ID NO:381, SEQ ID NO:382, SEQ ID NO:383, SEQ ID
NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388,
25 SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID

NO:393, SEQ ID NO:394 > SEQ ID NO:395, SEQ ID NO:396, SEQ ID NO:397,
SEQ TD NO:398> SEQ ID NO:399, SEQ ID NO;400, SEQ ID NO:401, SEQ ID
NO:402, SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406,
SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410 T SEQ ID

3 0 NO:411, SEQ ID NO:412, SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415,

SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418 ? SEQ ID NO:419, SEQ ID
NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424,
SEQ ID NO;425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428, SEQ ID
NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433,

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SEQ ID NO:434, SEQ ID NO:435, SEQ ID NO:436, SEQ ID NO:437, SEQ ID
NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441, SEQ ID NO:442,
SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446, SEQ ID
NO:447, SEQ ID NO:448, SEQ ID NO:449. SEQ ID NO:450, SEQ ID NO:45U
5 SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID

NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO;459, SEQ ID NO:460,
SEQ ID NO:461, SEQ ID NO;462, SEQ ID NO;463, SEQ ID NO:464 T SEQ ID
NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469,
SEQ ID NO:470, SEQ ID NO:471, SEQ ID NO:472, SEQ ID NO:473, SEQ ID

10 NO:474 T SEQ ID NO;475, SEQ ID NO:476, SEQ ID NO:477, SEQ ID NO:478,

SEQ ID NO:479, SEQ ID NO:480, SEQ ID NO:481, SEQ ID NO:482, SEQ ID
NO:483, SEQ ID NO:484, SEQ ID NO:485, SEQ ID NO:486, SEQ ID NO:487,
SEQ ID NO:488, SEQ ID NO:489, SEQ ID NO:490, SEQ ID NO:491, SEQ ID
NO:492, SEQ ID NO:493, SEQ ID NO:494, SEQ ID NO:495, SEQ ID NO:496,

15 SEQ ID NO:497, SEQ ID NO:498, SEQ ID NO:499, SEQ ID NO:500 r SEQ ID

NO:501, SEQ ID NO:502> SEQ ID NO:503, SEQ ID NO:504 7 SEQ ID NO:505,
SEQ ID NO:506, SEQ ID NO:507, SEQ ID NO:508, SEQ ID NO:509, SEQ ID
NO:510, SEQ ID NO:511, SEQ ID NO:512, SEQ ID NO:513, SEQ ID NO:514,
SEQ ID NO:515, SEQ ID NO:516, SEQ ID NO:517, SEQ ID NO:518, SEQ ID

20 NO:519 T SEQ ID NO:520, SEQ ID NO:521, SEQ ID NO:522, SEQ ID NO:523,

SEQ ID NO:524, SEQ ID NO:525, SEQ ID NO:526, SEQ ID NO:527, SEQ ID
NO:528, SEQ ID NO:529, SEQ ID NO:530, SEQ ID NO:531, SEQ ID NO:532,
SEQ ID NO:533, SEQ ID NO:534, SEQ ID NO:535, SEQ ID NO:536, SEQ ID
NO:537, SEQ ID NO:538, SEQ ID NO:539, SEQ ID NO:540, SEQ ID NO:541,

25 SEQ ID NO:542, SEQ ID NO:543, SEQ ID NO:544, SEQ ID NO:545, SEQ ID

NO:546, SEQ ID NO:547, SEQ ID NO:548, SEQ ID NO:549, SEQ ID NO:550,
SEQ ID NO:551, SEQ ID NO:552, SEQ ID NO:553, SEQ ID NO:554, SEQ ID
NO:555, SEQ ID NO:556, SEQ ID NO:557, SEQ ID NO:558 t SEQ ID NO:559,
SEQ ID NO:560, SEQ ID NO:561, SEQ ID NO:562, SEQ ID NO:563, SEQ ID

3 0 NO:564, SEQ ID NO:565, SEQ ID NO:566, SEQ ID NO:567, SEQ ID NO:568,

SEQ ID NO:569, SEQ ID NO:570, SEQ ID NO:571, SEQ ID NO:572, SEQ ID
NO:573, SEQ ID NO;574, SEQ ID NO:575, SEQ ID NO:576, SEQ ID NO:577,
SEQ ID NO:578, SEQ ID NO:579, SEQ ID NO:580, SEQ ID NO:581, SEQ ID
NO:582, SEQ ID NO:583, SEQ ID NO:584, SEQ ID NO:585, SEQ ID NO:586,

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25

PCT/US98/06956

SEQ ID NO:587, SEQ ID NO:588, SEQ ID NO:589, SEQ ID NO:590, SEQ ID
NO:591, SEQ ID NO:592, SEQ ID NO:593, SEQ ID NO:594, SEQ ID NO:595,
SEQ ID NO:596, SEQ ID NO:597, SEQ ID NO:598, SEQ ID NO:599, SEQ ID
NO:600, SEQ ID NO:601, SEQ ID NO:602, SEQ ID NO:603, SEQ ID NO:604,
SEQ ID NO:605, SEQ ID NO:606, SEQ ID NO:607, SEQ ID NO:608, SEQ ID
NO:609, SEQ ID NO:610, SEQ ID NO:6ih SEQ ID NO:612, SEQ ID NO:613,
SEQ ID NO:614, SEQ ID NO:615, SEQ ID NO:616, SEQ ID NO:617, SEQ ID
NO:6I8, SEQ ID NO:619, SEQ ID NO:620, SEQ ID NO:621, SEQ ID NO:622,
SEQ ID NO:623, SEQ ID NO:624, SEQ ID NO:625, SEQ ID NO:626, SEQ ID
NO:627, SEQ ID NO:628, SEQ ID NO:629, SEQ ID NO:630, SEQ ID NO:631,
SEQ ID NO:632, SEQ ID NO:633, SEQ ID NO:634, SEQ ID NO:635, SEQ ID
NO:636, SEQ ID NO:637, SEQ ID NO:638, SEQ ID NO:639, SEQ ID NO:640,
SEQ ID NO:641, SEQ ID NO:642, SEQ ID NO:643, SEQ ID NO:644, SEQ ID
NO:645, SEQ ID NO:646, SEQ ID NO:647, SEQ ID NO:648, SEQ ID NO:649,
SEQ ID NO:650, SEQ ID NO:651, SEQ ID NO:652, SEQ ID NO:653, SEQ ID
NO:654, SEQ ID NO:655, SEQ ID NO:656, SEQ ID NO:657, SEQ ID NO:658,
SEQ ID NO:659, SEQ ID NO:660, SEQ ID NO:661, SEQ ID NO:662, SEQ ID
NO:663, SEQ ID NO:664, SEQ ID NO:665, SEQ ID NO:666, SEQ ID NO:667,
SEQ ID NO:668, SEQ ID NO:669, SEQ ID NO:670, SEQ ID NO:671, SEQ ID
NO:672, SEQ ID NO:673, SEQ ID NO:674, SEQ ID NO:675, SEQ ID NO:676,
SEQ ID NO:677, SEQ ID NO:678, SEQ ID NO: 679, SEQ ID NO:680 T SEQ ID
NO:681 T SEQ ID NO:682, SEQ ID NO:683, SEQ ID NO;684, SEQ ID NO:685,
SEQ ID NO:686, SEQ ID NO:687, SEQ ID NO:688, SEQ ID NO:689, SEQ ID
NO:690, SEQ ID NO:691, SEQ ID NO:692, SEQ ID NO:693, SEQ ID NO:694,
SEQ ID NO:695, SEQ ID NO:696, SEQ ID NO:697, SEQ ID NO:698, SEQ ID
NO:699, SEQ ID NO:700, SEQ ID NO:701, SEQ ID NO:702, SEQ ID NO:703,
SEQ ID NO:704, SEQ ID NO:705, SEQ ID NO;706, SEQ ID NO:707, SEQ ID
NO:708, SEQ ID NO:709, SEQ ID NO:710, SEQ ID N0:711, SEQ ID NO:712,
SEQ ID NO:713, SEQ ID NO:714, SEQ ID NO:715, SEQ ID NO:716, SEQ ID
NO:717, SEQ ID NO:718, SEQ ID NO:719, SEQ ID NO:720, SEQ ID NO:721,
SEQ ID NO:722, SEQ ID NO:723 > SEQ ID NO:724, SEQ ID NO:725, SEQ ID
NO:726, SEQ ID NO:727, SEQ ID NO:728, SEQ ID NO:729, SEQ ID NO:730,
SEQ ID NO:731, SEQ ID NO:732, SEQ ID NO:733, SEQ ID NO:734, SEQ ID
NO:735, SEQ ID NO:736, SEQ ID NO:737, SEQ ID NO:738, SEQ ID NO:739,

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SEQ ID NO;740, SEQ ID NO:741, SEQ ID NO:742, SEQ ID NO:743, SEQ ID
NO:744, SEQ ID NO:745, SEQ ID NO:746, SEQ ID NO:747, SEQ ID NO:748,
SEQ ID NO.-749, SEQ ID NO:750, SEQ ID NO:751, SEQ ID NO:752, SEQ ID
NO:753, SEQ ID NO:754, SEQ ID NO:755, SEQ ID NO:756, SEQ ID NO:757,
5 SEQ ID NG:758, SEQ ID NO:759, SEQ ID NO:760, SEQ ID NO:76K SEQ ID

NO:762, SEQ ID NO:763, SEQ ID NO:764, SEQ ID NO:765, SEQ ID NO:766,
SEQ ID NO:767, SEQ ID NO:768, SEQ ID NO:769, SEQ ID NO:770, SEQ ID
NO:771, SEQ ID NO:772, SEQ ID NO:773, SEQ ID NO:774, SEQ ID NO:775,
SEQ ID NO;776, SEQ ID NO:777, SEQ ID NO:778, SEQ ID NO:779, SEQ ID

10 NO:780, SEQ ID NO:781, SEQ ID NO:782, SEQ ID NO:783, SEQ ID NO:784,

SEQ ID NO:785, SEQ ID NO:786, SEQ ID NO:787, SEQ ID NO:788, SEQ ID
NO:789, SEQ ID NO:790, SEQ ID NO:79l, SEQ ID NO:792, SEQ ID NO:793,
SEQ ID NO:794, SEQ ID NO:795, SEQ ID NO:796, SEQ ID NO:797, SEQ ID
NO:798, SEQ ID NO:799, SEQ ID NO:800, SEQ ID NO:801, SEQ ID NO:802,

15 SEQ ID NO:803, SEQ ID NO:804, SEQ ID NO:805, SEQ ID NO:806, SEQ ID

NO:807, SEQ ID NO:808, SEQ ID NO:809, SEQ ID NO:810 T SEQ ID NO:81 1,
SEQ ID NO:812 t SEQ ID NO:813, SEQ ID NO:814, SEQ ID NO:815, SEQ ID
NO:816, SEQ ID NO:817, SEQ ID NO:818, SEQ ID NO:8i9, SEQ ID NO:820,
SEQ ID NO:821, SEQ ID NO:822, SEQ ID NO:823, SEQ ID NO:824, SEQ ID

20 NO:825, SEQ ID NO:826, SEQ ID NO:827, SEQ ID NO:828 > SEQ ID NO:829,

SEQ ID NO:830, SEQ ID NO:831, SEQ ID NO:832, SEQ ID NO:833, SEQ ID
NO:834, SEQ ID NO:835, SEQ ID NO:836, SEQ ID NO:837, SEQ ID NO:838,
SEQ ID NO:839, SEQ ID NO:840, SEQ ID NO:841, SEQ ID NO: 842, SEQ ID
NO:843, SEQ ID NO:844, SEQ ID NO:845, SEQ ID NO:846, SEQ ID NO:847,

25 SEQ ID NO:848, SEQ ID NO:849, SEQ ID NO:850, SEQ ID NO:851, SEQ ID

NO:852, SEQ ID NO:853, SEQ ID NO:854, SEQ ID NO:855, SEQ ID NO:856,
SEQ ID NO:857, SEQ ID NO:858, SEQ ID NO:859 T SEQ ID NO:860, SEQ ID
NO:861, SEQ ID NO:862 > SEQ ID NO:863, SEQ ID NO:864, SEQ ID NO:865,
SEQ ID NO:866, SEQ ID NO:867, SEQ ID NO:868, SEQ ID NO:869, SEQ ID

3 0 NO:870, SEQ ID NO:871, SEQ ID NO:872 f SEQ ID NO:873, SEQ ID NO:874,

SEQ ID NO:875, SEQ ID NO:876, SEQ ID NO:877, SEQ ID NO:878, SEQ ID
NO:879, SEQ ID NO:880, SEQ ID NO:88I, SEQ ID NO:882, SEQ ID NO:883,
SEQ ID NO:884, SEQ ID NO:885, SEQ ID NO:886, SEQ ID NO:887, SEQ ID
NO:888, SEQ ID NO:889 > SEQ ID NO:890, SEQ ID NO:891, SEQ ID NO:892,

7

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SEQ ID NO:893, SEQ ID NO:894, SEQ ID NO:895, SEQ ID NO:896, SEQ ID
NO:897, SEQ ID NO:898, SEQ ID NO:899, SEQ ID NO:900, SEQ ID NO:901,
SEQ ID NO:902, SEQ ID NO:903, SEQ ID NO:904, SEQ ID NO:905, SEQ ID
NO:906, SEQ ID NO:907, SEQ ID NO:908, SEQ ID NO:909, SEQ ID NO:910,
5 SEQ ID NO-.911, SEQ ID NO:912, SEQ ID NO:9l3, SEQ ID NO:914, SEQ ID

NO:915, SEQ ID NO:916, SEQ ID NO:917, SEQ ID NO:918, SEQ ID NO:919,
SEQ ID NO:920, SEQ ID NO:921. SEQ ID NO:922, SEQ ID NO:923, SEQ ID
NO:924, SEQ ID NO:925, SEQ ID NO:926, SEQ ID NO:927, SEQ ID NO:928,
SEQ ID NO:929, SEQ ID NO:930, SEQ ID NO:931, SEQ ID NO:932, SEQ ID

10 NO:933, SEQ ID NO:934, SEQ ID NO:935, SEQ ID NO:936, SEQ ID NO:937,

SEQ ID NO:938, SEQ ID NO:939, SEQ ID NO:940, SEQ ID NO:941, SEQ ID
NO:942 T SEQ ID NO:943, SEQ ID NO:944, SEQ ID NO:945, SEQ ID NO:946,
SEQ ID NO:947, SEQ ID NO:948, SEQ ID NO:949, SEQ ID NO:950, SEQ ID
NO: 951, SEQ ID NO:952, SEQ ID NO:953, SEQ ID NO:954, SEQ ID NO:955 T

15 SEQ ID NO:956, SEQ ID NO:957, SEQ ID NO:958, SEQ ID NO:959, SEQ ID

NO:960, SEQ ID NO:961, SEQ ID NO:962, SEQ ID NO:963, SEQ ID NO:964,
SEQ ID NO:965 T SEQ ID NO:966, SEQ ID NO:967, SEQ ID NO:968, SEQ ID
NO:969, SEQ ID NO:970, SEQ ID NO:971, SEQ ID NO:972, SEQ ID NO:973,
SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:976, SEQ ID NO:977, SEQ ID

20 NO:978, SEQ ID NO:979 T SEQ ID NO:980, SEQ ID NO:981, SEQ ID NO:982,

SEQ ID NO:983, SEQ ID NO:984, SEQ ID NO:985, SEQ ID NO:986, SEQ ID
NO:987, SEQ ID NO:988, SEQ ID NO:989, SEQ ID NO:990, SEQ ID NO:991,
SEQ ID NO:992, SEQ ID NO:993, SEQ ID NO:994, SEQ ID NO:995 t SEQ ID
NO:996, SEQ ID NO:997, SEQ ID NO:998, SEQ ID NO:999 7 SEQ ID NO: 1000,

2 5 SEQ ID NO: 1001, SEQ ID NO: 1002, SEQ ID NO: 1003, SEQ ID NO: 1004, SEQ

ID NO: 1005, SEQ ID NO: 1006, SEQ ID NO: 1007, SEQ ID NO: 1008, SEQ ID
NO:1009, SEQ ID NO: 1010, SEQ ID NO:1011, SEQ ID NO:1012, SEQ ID
NO:1013, SEQ ID NO: 1014, SEQ ID NO:1015, SEQ ID NO:1016, SEQ ID
NO:1017, SEQ ID NO:1018, SEQ ID NO:1019, SEQ ID NO:1020, SEQ ID

30 NO:1021, SEQ ID NO:1022, SEQ ID NO:1023, SEQ ID NO:1024, SEQ ID

NO: 1025, SEQ ID NO: 1026, SEQ ID NO: 1027, SEQ ID NO: 1028, SEQ ID
NO:1029, SEQ ID NO:1030, SEQ ID NO:1031, SEQ ID NO:1032, SEQ ID
NO: 1033, SEQ ID NO: 1034, SEQ ID NO: 1035, SEQ ID NO: 1036, SEQ ID
NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1039, SEQ ID NO: 1040, SEQ ID

8

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NO; 1041, SEQ ID NO: 1042,
NO: 1045, SEQ ID NO: 1046,
NO: 1049, SEQ ID NO: 1050,
NO: 1053, SEQ ID NO: 1054,
5 NO: 1057, SEQ ID NO: 1058,

NO: 1061, SEQ ID NO: 1062,
NO: 1065, SEQ ID NO: 1066,
NO: 1069, SEQ ID NO: 1070,
NO: 1073, SEQ ID NO: 1074,

10 NO: 1077, SEQ ID NO: 1078,

NO: 108 1, SEQ ID NO: 1082,
NO: 1085, SEQ ID NO: 1086,
NO: 1089, SEQ ID NO: 1090,
NO: 1093, SEQ ID NO: 1094,

15 NO:1097, SEQ ID NO:1098,

NO: 1101, SEQ ID NO: 1102,
NO: 1105, SEQ ID NO: 1106,
NO: 1109, SEQ ID NO: 11 10,
NO: 11 13, SEQ ID NO: 11 14,

20 NO: 11 17, SEQ ID NO: 11 18,

NO: 1121, SEQ ID NO: 1122,
NO: 1125, SEQ ID NO: 1126,
NO: 1129, SEQ ID NO: 1130,
NO: 1133, SEQ ID NO: 1134,

25 NO: 1137, SEQ ID NO:1138,

NO: 1141, SEQ ID NO: 1142,
NO: 1145, SEQ ID NO: 1146,
NO: 1149, SEQ ID NO: 1150,
NO: 1153, SEQ ID NO: 1154,

3 0 NO: 1157, SEQ ID NO: 1158,

NO: 1161. SEQ ID NO: 1162,
NO: 1165, SEQ ID NO: 1166,
NO: 1169, SEQ ID NO: 1170,
NO: 1173, SEQ ID NO: 1174,

SEQ ID NO: 1043, SEQ ID NO: 1044, SEQ ID
SEQ ID NO: 1047, SEQ ID NO: 1048, SEQ ID
SEQ ID NO: 1051, SEQ ID NO: 1052, SEQ ID
SEQ ID NO: 1055, SEQ ID NO: 1056, SEQ ID
SEQ ID NO: 1059, SEQ ID NO: 1060, SEQ ID
SEQ ID NO: 1063, SEQ ID NO: 1064, SEQ ID
SEQ ID NO: 1067, SEQ ID NO: 1068, SEQ ID
SEQ ID NO: 1071, SEQ ID NO: 1072, SEQ ID
SEQ ID NO:1075, SEQ ID NO: 1076, SEQ ID
SEQ ID NO: 1079. SEQ ID NO: 1080, SEQ ID
SEQ ID NO: 1083, SEQ ID NO: 1084, SEQ ID
SEQ ID NO: 1087, SEQ ID NO: 1088, SEQ ID
SEQ ID NO: 1091, SEQ ID NO: 1092, SEQ ID
SEQ ID NO:1095, SEQ ID NO: 1096, SEQ ID
SEQ ID NO:1099, SEQ ID NO: 1100, SEQ ID
SEQ ID NO; 1103, SEQ ID NO: 1104, SEQ ID
SEQ ID NO: 1107, SEQ ID NO: 1108, SEQ ID
SEQ ID NO:llll, SEQ ID NO: 11 12, SEQ ID
SEQ ID NO: 11 15, SEQ ID NO: 11 16, SEQ ID
SEQ ID NO: 11 19, SEQ ID NO: 1120, SEQ ID
SEQ ID NO: 1123, SEQ ID NO: 1124, SEQ ID
SEQ ID NO: 1127, SEQ ID NO: 1128, SEQ ID
SEQ ID NO: 1 131, SEQ ID NO: 1132, SEQ ID
SEQ ID NO: 1135, SEQ ID NO: 1136, SEQ ID
SEQ ID NO: 1139, SEQ ID NO: 1140, SEQ ID
SEQ ID NO: 1143, SEQ ID NO: 1144, SEQ ID
SEQ ID NO: 1 147, SEQ ID NO: 1148, SEQ ID
SEQ ID NO: 1151, SEQ ID NO: 1152, SEQ ID
SEQ ID NO: 1155, SEQ ID NO: 1156, SEQ ID
SEQ ID NO: 1159, SEQ ID NO: 1160, SEQ ID
SEQ ID NO: 1163, SEQ ID NO: 1164, SEQ ID
SEQ ID NO: 1167, SEQ ID NO: 1168, SEQ ID
SEQ ID NO: 1171, SEQ ID NO: 1172, SEQ ID
SEQ ID NO: 1175, SEQ ID NO: 1176, SEQ ID

9

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NO: 1177, SEQ ID NO: 1 178, SEQ ID NO: 1179,
NO: 1181, SEQ ID NO:1182, SEQ ID NO:1183,
NO: 1185, SEQ ID NO: 1186, SEQ ID NO: 1187,
NO: 11 89, SEQ ID NO:1190, SEQ ID NO:1191,
5 NO: 1193, SEQ ID NO: 1194, SEQ ID NO: 1195,

NO: 1197, SEQ ID NO: 1198, SEQ ID NO: 1199,
NO: 1201, SEQ ID NO: 1202, SEQ ID NO: 1203,
NO: 1205, SEQ ID NO: 1206, SEQ ID NO: 1207,
NO: 1209, SEQ ID NO:1210, SEQ ID NO: 1211,

10 NO:1213, SEQ ID NO:1214, SEQ ID NO: 1215,

NO: 1217, SEQ ID NO:1218, SEQ ID NO: 1219,
NO: 1221, SEQ ID NO: 1222, SEQ ID NO: 1223,
NO: 1225, SEQ ID NO: 1226, SEQ ID NO: 1227,
NO: 1229, SEQ ID NO: 1230, SEQ ID NO: 1231,

15 NO: 1233, SEQ ID NO: 1234, SEQ ID NO: 1235,

NO: 1237, SEQ ID NO: 1238, SEQ ID NO: 1239,
NO: 1241, SEQ ID NO: 1242, SEQ ID NO: 1243,
NO: 1245, SEQ ID NO: 1246, SEQ ID NO: 1247,
NO: 1249, SEQ ID NO: 1250, SEQ ID NO: 1251,

2 0 NO: 1253, SEQ ID NO: 1254, SEQ ID NO: 1255,

NO: 1257, SEQ ID NO: 1258, SEQ ID NO: 1259,
NO:1261, SEQ ID NO:1262, SEQ ID NO:1263,
NO: 1265, SEQ ID NO: 1266, SEQ ID NO: 1267,
NO: 1269, SEQ ID NO: 1270, SEQ ID NO: 1271,

2 5 NO: 1273, SEQ ID NO: 1274, SEQ ID NO: 1275,

NO: 1277, SEQ ID NO: 1278, SEQ ID NO: 1279,.
NO: 1281, SEQ ID NO: 1282, SEQ ID NO: 1283,
NO: 1285, SEQ ID NO: 1286, SEQ ID NO: 1287,
NO: 1289, SEQ ID NO: 1290, SEQ ID NO: 1291,

3 0 NO: 1293, SEQ ID NO: 1294, SEQ ID NO: 1295,

NO: 1297, SEQ ID NO: 1298, SEQ ID NO: 1299,
NO: 1301, SEQ ID NO: 1302, SEQ ID NO: 1303,
NO: 1305, SEQ ID NO: 1306, SEQ ID NO: 1307,
NO:1309, SEQ ID NO:1310, SEQ ID NO:1311,

SEQ ID NO: 1180, SEQ ID
SEQ ID NO: 1184, SEQ ID
SEQ ID NO: 1188, SEQ ID
SEQ ID NO: 1192, SEQ ID
SEQ ID NO; 1196, SEQ ID
SEQ ID NO: 1200, SEQ ID
SEQ ID NO: 1204, SEQ ID
SEQ ID NO: 1208, SEQ ID
SEQ ID NO: 12 12, SEQ ID
SEQ ID NO: 1216, SEQ ID
SEQ ID NO: 1220, SEQ ID
SEQ ID NO: 1224, SEQ ID
SEQ ID NO: 1228, SEQ ID
SEQ ID NO: 1232, SEQ ID
SEQ ID NO: 1236, SEQ ID
SEQ ID NO: 1240, SEQ ID
SEQ ID NO: 1244, SEQ ID
SEQ ID NO: 1248, SEQ ID
SEQ ID NO: 1252, SEQ ID
SEQ ID NO: 1256, SEQ ID
SEQ ID NO: 1260, SEQ ID
SEQ ID NO: 1264, SEQ ID
SEQ ID NO: 1268, SEQ ID
SEQ ID NO: 1272, SEQ ID
SEQ ID NO: 1276, SEQ ID
SEQ ID NO: 1280, SEQ ID
SEQ ID NO: 1284, SEQ ID
SEQ ID NO: 1288, SEQ ID
SEQ ID NO: 1292, SEQ ID
SEQ ID NO: 1296, SEQ ID
SEQ ID NO: 1300, SEQ ID
SEQ ID NO: 1304, SEQ ID
SEQ ID NO: 1308, SEQ ID
SEQ ID NO: 1312, SEQ ID

10

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NO:1313, SEQ ID NO:1314,
NO:1317, SEQ ID NO:1318,
NO: 1-321. SEQ ID NO: 1322,
NO: 1325, SEQ ID NO: 1326,
5 NO: 1329, SEQ ID NO: 1330,

NO: 1333, SEQ ID NO: 1334,
NO: 1337, SEQ ID NO: 1338,
NO: 1341, SEQ ID NO: 1342,
NO: 1345, SEQ ID NO: 1346,

10 NO: 1349, SEQ ID NO: 1350,

NO: 1353, SEQ ID NO: 1354,
NO: 1357, SEQ ID NO: 1358,
NO:1361, SEQ ID NO:1362,
NO: 1365, SEQ ID NO: 1366,

15 NO: 1369, SEQ ID NO: 1370,

NO: 1373, SEQ ID NO: 1374,
NO: 1377, SEQ ID NO: 1378,
NO: 1381, SEQ ID NO: 1382,
NO: 1385, SEQ ID NO: 1386,

2 0 NO: 1389, SEQ ID NO: 1390,

NO: 1393, SEQ ID NO: 1394,
NO: 1397, SEQ ID NO: 1398,
NO: 1401, SEQ ID NO: 1402,
NO: 1405, SEQ ID NO: 1406,

2 5 NO: 1409, SEQ ID NO: 1410,

NO: 14 13, SEQ ID NO: 1414,
NO:14I7, SEQ ID NO: 1418,
NO: 1421, SEQ ID NO: 1422,
NO: 1425, SEQ ID NO: 1426,

3 0 NO: 1429, SEQ ID NO: 1430,

NO: 1433, SEQ ID NO: 1434,
NO: 1437, SEQ ID NO: 1438,
NO: 1441, SEQ ID NO: 1442,
NO: 1445, SEQ ID NO: 1446,

SEQ ID NO: 13 15. SEQ ID NO: 13 16, SEQ ID
SEQ ID NO:1319. SEQ ID NO:1320, SEQ ID
SEQ ID NO: 1323, SEQ ID NO: 1324, SEQ ID
SEQ ID NO: 1327, SEQ ID NO: 1328, SEQ ID
SEQ ID NO: 1331, SEQ ID NO: 1332, SEQ ID
SEQ ID NO: 1335, SEQ ID NO: 1336, SEQ ID
SEQ ID NO: 1339, SEQ ID NO: 1340, SEQ ID
SEQ ID NO: 1343, SEQ ID NO: 1344, SEQ ID
SEQ ID NO: 1347, SEQ ID NO: 1348, SEQ ID
SEQ ID NO:I351, SEQ ID NO:l352, SEQ ID
SEQ ID NO: 1355, SEQ ID NO: 1356, SEQ ID
SEQ ID NO: 1359, SEQ ID NO: 1360, SEQ ID
SEQ ID NO: 1363, SEQ ID NO: 1364, SEQ ID
SEQ ID NO: 1367, SEQ ID NO: 1368, SEQ ID
SEQ ID NO: 1371, SEQ ID NO: 1372, SEQ ID
SEQ ID NO: 1375, SEQ ID NO: 1376, SEQ ID
SEQ ID NO: 1379, SEQ ID NO: 1380, SEQ ID
SEQ ID NO: 1383, SEQ ID NO: 1384, SEQ ID
SEQ ID NO: 1387, SEQ ID NO: 1388, SEQ ID
SEQ ID NO: 1391, SEQ ID NO: 1392, SEQ ID
SEQ ID NO: 1395, SEQ ID NO: 1396, SEQ ID
SEQ ID NO: 1399, SEQ ID NO: 1400, SEQ ID
SEQ ID NO: 1403, SEQ ID NO: 1404, SEQ ID
SEQ ID NO: 1407, SEQ ID NO: 1408, SEQ ID
SEQ ID NO: 1411, SEQ ID NO:1412, SEQ ID
SEQ ID NO: 1415, SEQ ID NO: 1416, SEQ ID
SEQ ID NO: 1419, SEQ ID SEQ ID

SEQ ID NO: 1423, SEQ ID NO: 1424, SEQ ID
SEQ ID NO: 1427, SEQ ID NO: 1428, SEQ ID
SEQ ID NO: 1431, SEQ ID NO: 1432, SEQ ID
SEQ ID NO: 1435, SEQ ID NO: 1436, SEQ ID
SEQ ID NO: 1439, SEQ ID NO: 1440, SEQ ID
SEQ ID NO: 1443, SEQ ID NO: 1444, SEQ ID
SEQ ID NO: 1447, SEQ ID NO: 1448, SEQ ID

11

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NO: 1449, SEQ ID NO: 1450, SEQ ID NO: 1451, SEQ ID NO: 1452, SEQ ID
NO: 1453, SEQ ID NO: 1454, SEQ ID NO: 1455, SEQ ID NO: 1456, SEQ ID
NO: 1457, SEQ ID NO: 1458, SEQ ID NO: 1459, SEQ ID NO: 1460, SEQ ID
NO: 1461, SEQ ID NO: 1462, SEQ ID NO: 1463, SEQ ID NO: 1464, SEQ ID
5 NO: 1465, SEQ ID NO: 1466, SEQ ID NO: 1467, SEQ ID NO: 1468, SEQ ID

NO: 1469, SEQ ID NO: 1470, SEQ ID NO: 1471, SEQ ID NO: 1472, SEQ ID
NO: 1473, SEQ ID NO: 1474, SEQ ID NO: 1475, SEQ ID NO: 1476, SEQ ID
NO: 1477, SEQ ID NO: 1478, SEQ ID NO: 1479, SEQ ID NO: 1480, SEQ ID
NO:1481, SEQ ID NO:1482, SEQ ID NO:1483, SEQ ID NO:1484, SEQ ID

10 NO: 1485, SEQ ID NO: 1486, SEQ ID NO: 1487, SEQ ID NO: 1488, SEQ ID

NO: 1489, SEQ ID NO: 1490, SEQ ID NO: 1491, SEQ ID NO: 1492, SEQ ID
NO: 1493, SEQ ID NO: 1494, SEQ ID NO: 1495, SEQ ID NO: 1496, SEQ ID
NO: 1497, SEQ ID NO: 1498, SEQ ID NO: 1499, SEQ ID NO: 1500, SEQ ID
NO: 1501, SEQ ID NO: 1502, SEQ ID NO: 1503, SEQ ID NO: 1504, SEQ ID

15 NO:1505, SEQ ID NO:1506, SEQ ID NO:1507, SEQ ID NO:1508, SEQ ID

NO:1509, SEQ ID NO:1510, SEQ ID NO:1511, SEQ ID NO:1512, SEQ ID
NO:1513, SEQ ID NO:15l4, SEQ ID NO:1515, SEQ ID NO:1516, SEQ ID
NO: 15 17, SEQ ID NO: 1518, and SEQ ID NO: 1519;
or a complement of said sequence.

2 0 In other embodiments, the present invention provides an isolated polynucleotide

consisting of a nucleotide sequence selected from the group consisting of:

SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ
ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO: 10, SEQ ID
NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ
25 ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO:20, SEQ

ID NO:21 , SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ
ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ
ID NO:31 , SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ
ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ

3 0 ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ

ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ
ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ
ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ
ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ

12

PCT/US98/06956

ID NO:66, SEQ ID NO:67, SEQ ID NO;68, SEQ ID NO:69, SEQ ID NO:70, SEQ
ID N0:7I, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ
ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ
ID N0:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ
ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ
ID N0:9l, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ
ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO: 100,
SEQ ID NO; 101, SEQ ID NO: 102, SEQ ID NO: 103, SEQ ID NO: 104, SEQ ID
NO: 105, SEQ ID NO: 106, SEQ ID NO: 107, SEQ ID NO: 108, SEQ ID NO: 109,
SEQ fD NO: 1 10, SEQ ID NO: 111, SEQ ID NO: 112, SEQ ID NO: 113, SEQ ID
NO: 1 14, SEQ ID NO: 1 15, SEQ ID NO: 1 16, SEQ ID NO: 1 17, SEQ ID NO: 118,
SEQ ID NO: 119, SEQ ID NO:120, SEQ ID NO:121, SEQ ID NO:122, SEQ ID
NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 127,
SEQ ID NO: 128, SEQ ID NO:129, SEQ ID NO:130, SEQ ID NO:131, SEQ ID
NO: 132, SEQ ID NO: 133, SEQ ID NO: 134, SEQ ID NO: 135, SEQ ID NO: 136,
SEQ ID NO: 137, SEQ ID NO: 138, SEQ ID NO: 139, SEQ ID NO: 140, SEQ ID
NO:141, SEQ ID NO: 142, SEQ ID NO:143, SEQ ID NO:144, SEQ ID NO:145,
SEQ ID NO: 146, SEQ ID NO: 147, SEQ ID NO: 148, SEQ ID NO: 149, SEQ ID
NO: 150, SEQ ID NO: 151, SEQ ID NO: 152, SEQ ID NO: 153, SEQ ID NO: 154,
SEQ ID NO: 155, SEQ ID NO: 156, SEQ ID NO: 157, SEQ ID NO: 158, SEQ ID
NO: 159, SEQ ID NO: 160, SEQ ID NO: 161, SEQ ID NO: 162, SEQ ID NO: 163,
SEQ ID NO:164, SEQ ID NO:165, SEQ ID NO:166, SEQ ID NO:167, SEQ ID
NO:168,SEQID NO: 169, SEQ ID NO: 170, SEQ ID NO: 171, SEQ ID NO: 172,
SEQ ID NO: 173, SEQ ID NO: 174, SEQ ID NO: 175, SEQ ID NO: 176, SEQ ID
NO: 177, SEQ ID NO: 178, SEQ ID NO: 179, SEQ ID NO: 180, SEQ ID NO: 181,
SEQ ID NO: 182, SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO: 185, SEQ ID
NO:186, SEQ ID NO:187, SEQ ID NO:188, SEQ ID NO:189, SEQ ID NO:190,
SEQ ID NO:191, SEQ ID NO:192, SEQ ID NO:193, SEQ ID NO:194, SEQ ID
NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199,
SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID
NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208,
SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:211, SEQ ID NO:212, SEQ ID
NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217,
SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID

13

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5

10

15

20

25

PCTYUS98/06956

NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226,
SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID
NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235,
SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238, SEQ ID NO:239, SEQ ID
NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244,
SEQ ID NO:245, SEQ ID NO;246, SEQ ID NO:247, SEQ ID NO:248, SEQ ID
NO:249, SEQ ID NO:250, SEQ ID NO:25K SEQ ID NO:252, SEQ ID NO:253,
SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID
NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:26i, SEQ ID NO:262,
SEQ ID NO:263, SEQ ID NO;264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID
NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271,
SEQ ID NO:272 t SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275 T SEQ ID
NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280,
SEQ ID NO:281, SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID
NO:285, SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289,
SEQ ID NO:290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID NO:293, SEQ ID
NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297 ? SEQ ID NO:298,
SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO:301, SEQ ID NO.302, SEQ ID
NO:303 T SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307,
SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:310, SEQ ID NO:311, SEQ ID
NO:3I2, SEQ ID NO:313, SEQ ID NO:314, SEQ ID N0:315, SEQ ID NO:3I6,
SEQ ID NO:317, SEQ ID NO:318, SEQ ID NO:319, SEQ ID NO:320, SEQ ID
NO:321, SEQ ID NO:322, SEQ ID NO:323, SEQ ID NO:324, SEQ ID NO:325,
SEQ ID NO:326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID
NO:330, SEQ ID NO:331, SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334,
SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO:338, SEQ ID
NO:339, SEQ ID NO:340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO;343,
SEQ ID NO:344, SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID
NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352,
SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356, SEQ ID
NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO:360, SEQ ID NO:361,
SEQ ID NO.362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID
NO:366, SEQ ID NO:367, SEQ ID NO:368, SE(^ ID NO:369, SEQ ID NO:370,
SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373, SEQ ID NO:374, SEQ ID

14

PCTAJS98/069S6

NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379,
SEQ ID NO:380, SEQ ID NO:381, SEQ ID NO:382. SEQ ID NO:383, SEQ ID
NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:-387, SEQ ID NO:388,
SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID
NO:393. SEQ ID NO:394, SEQ ID NO:395, SEQ ID NO:396, SEQ ID NO:397,
SEQ ID NO:398, SEQ ID NO:399, SEQ ID NO:400, SEQ ID NO:401, SEQ ID
NO:402, SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406,
SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410, SEQ ID
NO:41 1, SEQ ID NO:412, SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415,
SEQ ID NO:416, SEQ ID NO:4I7, SEQ ID NO:4i8, SEQ ID NO:419, SEQ ID
NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424,
SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428, SEQ ID
NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433,
SEQ ID NO:434, SEQ ID NO:435, SEQ ID NO:436, SEQ ID NO:437, SEQ ID
NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441, SEQ ID NO:442,
SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446, SEQ ID
NO:447, SEQ ID NO:448, SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451,
SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID
NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO:459, SEQ ID NO:460,
SEQ ID NO:461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO:464, SEQ ID
NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469,
SEQ ID NO;470, SEQ ID NO:471, SEQ ID NO:472, SEQ ID NO:473, SEQ ID
NO:474, SEQ ID NO:475 1 SEQ ID NO:476, SEQ ID NO:477 > SEQ ID NO:478,
SEQ ID NO:479, SEQ ID NO:480, SEQ ID NO:481, SEQ ID NO:482, SEQ ID
NO:483, SEQ ID NO;484, SEQ ID NO:485, SEQ ID NO:486, SEQ ID NO:487,
SEQ ID NO:488, SEQ ID NO:489 ? SEQ ID NO:490, SEQ ID NO:491, SEQ ID
NO:492, SEQ ID NO:493, SEQ ID NO:494, SEQ ID NO:495, SEQ ID NO:496,
SEQ ID NO:497> SEQ ID NO:498, SEQ ID NO:499, SEQ ID NO:500, SEQ ID
NO:501, SEQ ID NO:502, SEQ ID NO:503, SEQ ID NO;504, SEQ ID NO:505,
SEQ ID NO:506, SEQ ID NO:507, SEQ ID NO:508, SEQ ID NO:509, SEQ ID
NO:510, SEQ ID NO:511, SEQ ID NO:512, SEQ ID NO:513, SEQ ID NO:5H,
SEQ ID NO:515, SEQ ID NO:516, SEQ ID NO:517, SEQ ID NO:518, SEQ ID
NO:519, SEQ ID NO:520, SEQ ID NO:521, SEQ ID NO:522, SEQ ID NO:523,
SEQ ID NO:524, SEQ ID NO:525, SEQ ID NO:526, SEQ ID NO:527, SEQ ID

15

WO 98/45437 PCT/US98/06956

NO:528, SEQ ID NO:529, SEQ ID NO:530, SEQ ID NO:531, SEQ ID NO:532,
SEQ ID NO:533, SEQ ID NO:534, SEQ ID NO:535, SEQ ID NO:536, SEQ ID
NO:537, SEQ ID NO:538, SEQ ID NO:539, SEQ ID NO:540, SEQ ID NO:541,
SEQ ID NO:542, SEQ ID NO:543, SEQ ID NO:544, SEQ ID NO:545, SEQ ID
5 NO:546, SEQ ID NO:547, SEQ ID NO:548, SEQ ID NO:549, SEQ ID NO:550,

SEQ ID NO:551, SEQ ID NO:552, SEQ ID NO:553, SEQ ID NO:554, SEQ ID
1^0:555, SEQ ID NO:556, SEQ ID NO:557, SEQ ID NO:558, SEQ ID NO:559,
SEQ ID NO:560, SEQ ID NO:561, SEQ ID NO:562, SEQ ID NO:563, SEQ ID
NO:564, SEQ ID NO:565, SEQ ID NO:566, SEQ ID NO:567, SEQ ID NO:568,

10 SEQ ID NO:569, SEQ ID NO:570, SEQ ID NO:571, SEQ ID NO:572, SEQ ID

NO:573, SEQ ID NO:574, SEQ ID NO:575, SEQ ID NO:576, SEQ ID NO:577,
SEQ ID NO:578, SEQ ID NO:579, SEQ ID NO:580, SEQ ID NO:58l, SEQ ID
NO:582, SEQ ID NO:583, SEQ ID NO:584, SEQ ID NO:585 t SEQ ID NO:586,
SEQ ID NO:587, SEQ ID NO:588, SEQ ID NO:589, SEQ ID NO:590, SEQ ID

15 NO:591, SEQ ID NO:592, SEQ ID NO:593, SEQ ID NO:594, SEQ ID NO:595,

SEQ ID NO:596, SEQ ID NO:597, SEQ ID NO:598, SEQ ID NO:599, SEQ ID
NO:600, SEQ ID NO:60i, SEQ ID NO:602, SEQ ID NO:603, SEQ ID NO:604,
SEQ ID NO:605, SEQ ID NO:606, SEQ ID NO:607, SEQ ID NO:608, SEQ ID
NO:609, SEQ ID NO:610, SEQ ID NO:611, SEQ ID NO:612, SEQ ID NO:613,

20 SEQ ID NO:614, SEQ ID NO:615, SEQ ID NO:6l6, SEQ ID NO:617, SEQ ID

NO:618, SEQ ID NO:619, SEQ ID NO:620, SEQ ID NO:621, SEQ ID NO:622,
SEQ ID NO:623, SEQ ID NO:624, SEQ ID NO:625, SEQ ID NO:626 t SEQ ID
NO:627, SEQ ID NO:628, SEQ ID NO:629, SEQ ID NO:630, SEQ ID NO:631,
SEQ ID NO:632, SEQ ID NO:633, SEQ ID NO:634, SEQ ID NO:635, SEQ ID

2 5 NO:636, SEQ ID NO:637, SEQ ID NO:638, SEQ ID NO:639, SEQ ID NO:640 t

SEQ ID NO:641, SEQ ID NO:642, SEQ ID NO:643, SEQ ID NO:644, SEQ ID
NO:645, SEQ ID NO:646, SEQ ID NO:647, SEQ ID NO:648, SEQ ID NO:649,
SEQ ID NO:650, SEQ ID NO:651, SEQ ID NO:652, SEQ ID NO:653, SEQ ID
NO:654, SEQ ID NO:655, SEQ ID NO:656, SEQ ID NO:657, SEQ ID NO:658,

3 0 SEQ ID NO:659, SEQ ID NO:660, SEQ ID NO:661, SEQ ID NO:662 r SEQ ID

NO:663, SEQ ID NO:664, SEQ ID NO:665, SEQ ID NO:666, SEQ ID NO:667,
SEQ ID NO:668, SEQ ID NO:669, SEQ ID NO:670> SEQ ID NO:671, SEQ ID
NO:672, SEQ ID NO:673, SEQ ID NO:674, SEQ ID NO:675, SEQ ID NO:676,
SEQ ID NO:677, SEQ ID NO:678, SEQ ID NO:679, SEQ ID NO:680, SEQ ID

16

PCT/US98/06956

NO:68l, SEQ ID NO:682, SEQ ID NO;683, SEQ ID NO:684, SEQ ID NO:685,
SEQ ID NO:686, SEQ ID NO:687, SEQ ID NO:688, SEQ ID NO:689, SEQ ID
NO:690, SEQ ID NO:691, SEQ ID NO:692, SEQ ID NO:693, SEQ ID NO:694,
SEQ ID NO:695, SEQ ID NO:696, SEQ ID NO:697, SEQ ID NO:698, SEQ ID
NO:699, SEQ ID NO:700, SEQ ID NO:701, SEQ ID NO:702, SEQ ID NO:703,
SEQ ID NO:704, SEQ ID NO:705, SEQ ID NO:706, SEQ ID NO:707, SEQ ID
NO:708,SEQ ID NO:709, SEQ ID NO:710, SEQ ID NO:711, SEQ ID NO:712 t
SEQ ID NO:713, SEQ ID NO:714, SEQ ID NO:715, SEQ ID NO:716, SEQ ID
NO:717. SEQ ID NO:718, SEQ ID NO:719, SEQ ID NO:720, SEQ ID NO:721,
SEQ ID NO:722, SEQ ID NO:723, SEQ ID NO:724, SEQ ID NO:725, SEQ ID
NO:726, SEQ ID NO:727, SEQ ID NO:728, SEQ ID NO:729, SEQ ID NO:730,
SEQ ID NO:731, SEQ ID NO:732, SEQ ID NO:733, SEQ ID NO:734 t SEQ ID
NO:735, SEQ ID NO:736, SEQ ID NO:737, SEQ ID NO:738, SEQ ID NO:739,
SEQ ID NO:740, SEQ ID NO:741, SEQ ID NO:742, SEQ ID NO:743, SEQ ID
NO:744, SEQ ID NO:745, SEQ ID NO:746, SEQ ID NO:747, SEQ ID NO:748,
SEQ ID NO:749, SEQ ID NO:750, SEQ ID NO:751, SEQ ID NO:752, SEQ ID
NO:753, SEQ ID NO:754, SEQ ID NO:755, SEQ ID NO:756, SEQ ID NO:757,
SEQ ID NO:758, SEQ ID NO:759, SEQ ID NO:760, SEQ ID NO:761, SEQ ID
NO:762, SEQ ID NO:763, SEQ ID NO:764, SEQ ID NO:765, SEQ ID NO:766,
SEQ ID NO:767, SEQ ID NO:768, SEQ ID NO:769, SEQ ID NO:770, SEQ ID
NO:771, SEQ ID NO:772, SEQ ID NO:773, SEQ ID NO:774, SEQ ID NO:775,
SEQ ID NO:776, SEQ ID NO:777, SEQ ID NO:778, SEQ ID NO:779, SEQ ID
NO:780, SEQ ID NO:781, SEQ ID NO:782 t SEQ ID NO:783, SEQ ID NO:784,
SEQ ID NO:785, SEQ ID NO:786, SEQ ID NO:787, SEQ ID NO:788, SEQ ID
NO:789, SEQ ID NO:790, SEQ ID NO:791, SEQ ID NO:792, SEQ ID NO:793,
SEQ ID NO:794, SEQ ID NO:795, SEQ ID NO:796, SEQ ID NO:797, SEQ ID
NO:798, SEQ ID NO:799, SEQ ID NO:800, SEQ ID NO:80I, SEQ ID NO:802,
SEQ ID NO:803, SEQ ID NO:804, SEQ ID NO:805, SEQ ID NO:806, SEQ ID
NO:807, SEQ ID NO:808, SEQ ID NO:809, SEQ ID NO:810, SEQ ID NO:811,
SEQ ID NO:812, SEQ ID NO:813, SEQ ID NO:814, SEQ ID NO:815, SEQ ID
NO:816, SEQ ID NO;817, SEQ ID NO:818, SEQ ID NO:819, SEQ ID NO;820,
SEQ ID NO:821, SEQ ID NO:822, SEQ ID NO:823, SEQ ID NO:824, SEQ ID
NO:825, SEQ ID NO:826, SEQ ID NO:827, SEQ ID NO:828, SEQ ID NO:829,
SEQ ID NO:830, SEQ ID NO:831, SEQ ID NO:832, SEQ ID NO:833, SEQ ID

17

WO 98/45437

PCT/US98/06956

10

15

20

25

30

NO:834, SEQ ID NO:835, SEQ ID NO:836, SEQ ID NO:837, SEQ ID NO:838,
SEQ ID NO:839, SEQ ID NO:840, SEQ ID NO:841, SEQ ID NO:842, SEQ ID
NO:843, SEQ ID NO:844, SEQ ID NO:845, SEQ ID NO:846, SEQ ID NO:847,
SEQ ID NO:848, SEQ ID NO:849, SEQ ID NO:850, SEQ ID NO;851, SEQ ID
NO:852, SEQ ID NO:853, SEQ ID NO:854, SEQ ID NO:855, SEQ ID NO:856,
SEQ ID NO:857, SEQ ID NO:858, SEQ ID NO:859, SEQ ID NO:860, SEQ ID
NO:861, SEQ ID NO:862, SEQ ID NO:863, SEQ ID NO:864, SEQ ID NO:865,
SEQ ID NO:866, SEQ ID NO:867, SEQ ID NO:868, SEQ ID NO:869, SEQ ID
NO:870, SEQ ID NO:871, SEQ ID NO:872, SEQ ID NO:873, SEQ ID NO:874,
SEQ ID NOMS, SEQ ID NO:876, SEQ ID NO:877, SEQ ID NO;878, SEQ ID
NO:879, SEQ ID NO:880, SEQ ID NO:881, SEQ ID NO:882, SEQ ID NO:883,
SEQ ID NO:884, SEQ ID NO:885, SEQ ID NO:886, SEQ ID NO:887, SEQ ID
NO:888, SEQ ID NO:889, SEQ ID NO:890, SEQ ID NO:891, SEQ ID NO:892,
SEQ ID NO:893, SEQ ID NO:894, SEQ ID NO:895, SEQ ID NO:896, SEQ ID
NO:897, SEQ ID NO:898, SEQ ID NO:899, SEQ ID NO:900, SEQ ID NO:901,
SEQ ID NO:902, SEQ ID NO:903, SEQ ID NO:904, SEQ ID NO:905, SEQ ID
NO:906, SEQ ID NO:907, SEQ ID NO:908, SEQ ID NO:909, SEQ ID NO:910,
SEQ ID NO:911, SEQ ID NO:912, SEQ ID NO:9l3, SEQ ID NO:914, SEQ ID
NO:915, SEQ ID NO:9I6, SEQ ID NO:917, SEQ ID NO:9I8, SEQ ID NO:919,
SEQ ID NO.920, SEQ ID NO:921, SEQ ID NO:922, SEQ ID NO:923, SEQ ID
NO:924, SEQ ID NO:925, SEQ ID NO:926, SEQ ID NO:927, SEQ ID NO:928,
SEQ ID NO:929, SEQ ID NO:930, SEQ ID NO:931, SEQ ID NO:932, SEQ ID
NO:933, SEQ ID NO:934, SEQ ID NO:935, SEQ ID NO:936, SEQ ID NO:937,
SEQ ID NO:938, SEQ ID NO:939, SEQ ID NO:940, SEQ ID NO:941, SEQ ID
NO:942, SEQ ID NO:943, SEQ ID NO:944, SEQ ID NO:945, SEQ ID NO:946,
SEQ ID NO:947, SEQ ID NO:948, SEQ ID NO:949, SEQ ID NO:950, SEQ ID
NO:951, SEQ ID NO:952, SEQ ID NO:953, SEQ ID NO:954, SEQ ID NO;955,
SEQ ID NO:956, SEQ ID NO:957 T SEQ ID NO:958, SEQ ID NO:959, SEQ ID
NO:960, SEQ ID NO:961, SEQ ID NO:962, SEQ ID NO:963, SEQ ID NO:964,
SEQ ID NO:965, SEQ ID NO:966, SEQ ID NO:967, SEQ ID NO:968, SEQ ID
NO;969, SEQ ID NO:970, SEQ ID NO:971, SEQ ID NO:972, SEQ ID NO:973,
SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:976, SEQ ID NO:977, SEQ ID
NO:978, SEQ ID NO;979, SEQ ID NO:980, SEQ ID NO:981, SEQ ID NO:982,
SEQ ID NO:983, SEQ ID NO:984, SEQ ID NO:985, SEQ ID NO:986, SEQ ID

18

iiiiiiiiiif

WO 98/45437

PCT/US98/06956

NO:987, SEQ ID NO:988, SEQ ID NO:989, SEQ ID NO:990, SEQ ID NO:991,
SEQ ID NO:992, SEQ ID NO:993. SEQ ID NO:994, SEQ ID NO:995, SEQ ID
NO:996, SEQ ID NO:997, SEQ ID NO:998, SEQ ID NO:999, SEQ ID NO: 1000,
SEQ ID NO: 1001, SEQ ID NO: 1002, SEQ ID NO: 1003, SEQ ID NO: 1004, SEQ
5 ID NO: 1005, SEQ ID NO: 1006, SEQ ID NO: 1007, SEQ ID NO: 1008, SEQ ID

NO: 1009, SEQ ID NO: 1010, SEQ ID NO: 1011, SEQ ID NO: 1012, SEQ ID
NO: 1013, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1016, SEQ ID
NO: 1017, SEQ ID NO: 1018, SEQ ID NO: 1019, SEQ ID NO: 1020, SEQ ID
NO: 1021, SEQ ID NO:1022, SEQ ID NO:1023, SEQ ID NO:1024, SEQ ID

10 NO: 1025, SEQ ID NO: 1026, SEQ ID NO: 1027, SEQ ID NO: 1028, SEQ ID

NO: 1029, SEQ ID NO: 1030, SEQ ID NO: 1031, SEQ ID NO: 1032, SEQ ID
NO: 1033, SEQ ID NO: 1034, SEQ ID NO: 1035, SEQ ID NO: 1036, SEQ ID
NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1039, SEQ ID NO: 1040, SEQ ID
NO: 1041, SEQ ID NO: 1042, SEQ ID NO: 1043, SEQ ID NO: 1044, SEQ ID

15 NO: 1045, SEQ ID NO: 1046, SEQ ID NO: 1047, SEQ ID NO: 1048, SEQ ID

NO: 1049, SEQ ID NO: 1050, SEQ ID NO: 1051, SEQ ID NO: 1052, SEQ ID
NO: 1053, SEQ ID NO: 1054, SEQ ID NO: 1055, SEQ ID NO: 1056, SEQ ID
NO: 1057, SEQ ID NO: 1058, SEQ ID NO: 1059, SEQ ID NO: 1060, SEQ ID
NO:1061, SEQ ID NO:1062, SEQ ID NO: 1063, SEQ ID NO:1064, SEQ ID

20 NO: 1065, SEQ ID NO: 1066, SEQ ID NO: 1067, SEQ ID NO: 1068, SEQ ID

NO: 1069, SEQ ID NO: 1070, SEQ ID NO: 1071, SEQ ID NO: 1072, SEQ ID
NO: 1073, SEQ ID NO: 1074, SEQ ID NO: 1075, SEQ ID NO: 1076, SEQ ID
NO: 1077, SEQ ID NO: 1078, SEQ ID NO: 1079, SEQ ID NO: 1080, SEQ ID
NO:1081, SEQ ID NO:1082, SEQ ID NO:1083, SEQ ID NO:1084, SEQ ID

25 NO:1085, SEQ ID NO:1086, SEQ ID NO:1087, SEQ ID NO:1088, SEQ ID

NO: 1089, SEQ ID NO: 1090, SEQ ID NO: 1091, SEQ ID NO: 1092, SEQ ID
NO: 1093, SEQ ID NO: 1094, SEQ ID NO: 1095, SEQ ID NO: 1096, SEQ ID
NO:1097 T SEQ ID NO:1098, SEQ ID NO:1099, SEQ ID NO:1100, SEQ ID
NO: 1101, SEQ ID NO: 1102, SEQ ID NO:1103, SEQ ID NO: 1104, SEQ ID

3 0 NO: 1105, SEQ ID NO: 1106, SEQ ID NO: 1107, SEQ ID NO: 1108, SEQ ID

NO: 1109, SEQ ID NO: 11 10, SEQ ID NOrllll, SEQ ID NO: 11 12, SEQ ID
NO: 11 13, SEQ ID NO: 11 14, SEQ ID NO: 11 15, SEQ ID NO: 11 16, SEQ ID
NO: 11 17, SEQ ID NO: 11 18, SEQ ID NO: 11 19, SEQ ID NO: 1120, SEQ ID
NO:I121, SEQ ID NO: 1122, SEQ ID NO:1123, SEQ ID NO: 1124, SEQ ID

19

WO 98/45437

PCT/US98/06956

NO: 1125, SEQ ID NO: 1 126,
NO: 1129, SEQ ID NO: 1130,
NO: 1133, SEQ ID NO: 1134,
NO: 1137, SEQ ID NO: 1138,
5 NO:1141, SEQ ID NO: 1142.

NO: 1145, SEQ ID NO: 1146,
NO: 1149, SEQ ID NO: 1150,
NO: 1153, SEQ ID NO: 1154,
NO: 1157, SEQ ID NO: 1158,

10 NO: 1161, SEQ ID NO: 1162,

NO: 1165, SEQ ID NO: 1166,
NO: 1169, SEQ ID NO: 1170,
NO: 1173, SEQ ID NO: 1174,
NO: 1177, SEQ ID NO: 1178,

15 NO:1181, SEQ ID NO:I182,

NO: 11 85, SEQ ID NO: 11 86,
NO: 1189, SEQ ID NO: 1190,
NO: 1193, SEQ ID NO: 1194,
NO: 1197, SEQ ID NO: 1198,

20 NO: 1201, SEQ ID NO: 1202,

NO: 1205, SEQ ID NO: 1206,
NO: 1209, SEQ ID NO: 1210,
NO:1213, SEQ ID NO:1214,
NO: 1217, SEQ ID NO: 1218,

2 5 NO: 1221, SEQ ID NO: 1222,

NO: 1225, SEQ ID NO: 1226,
NO: 1*229, SEQ ID NO: 1230,
NO: 1233, SEQ ID NO: 1234,
NO: 1237, SEQ ID NO: 1238,

3 0 NO: 1241, SEQ ID NO: 1242,

NO: 1245, SEQ ID NO: 1246,
NO: 1249, SEQ ID NO: 1250,
NO: 1253, SEQ ID NO: 1254,
NO: 1257, SEQ ID NO: 1258,

SEQ ID NO:1127, SEQ ID NO:1128, SEQ ID
SEQ ID NO: 1131, SEQ ID NO:1132, SEQ ID
SEQ ID NO: 1135, SEQ ID NO: 1136, SEQ ID
SEQ ID NO: 1139. SEQ ID NO: 1140, SEQ ID
SEQ ID NO: 1143, SEQ ID NO: 1144, SEQ ID
SEQ ID NO: 1147, SEQ ID NO: 1148, SEQ ID
SEQ ID NO: 1151, SEQ ID NO: 1152, SEQ ID
SEQ ID NO: 1155, SEQ ID NO: 1156, SEQ ID
SEQ ID NO: 1159, SEQ ID NO: 1160, SEQ ID
SEQ ID NO: 1163, SEQ ID NO: 1164, SEQ ID
SEQ ID NO: 1167, SEQ ID NO: 1168, SEQ ID
SEQ ID NO: 1171, SEQ ID NO: 1172, SEQ ID
SEQ ID NO: 1175, SEQ ID NO: 1176, SEQ ID
SEQ ID NO: 1179, SEQ ID NO: 1180, SEQ ID
SEQ ID NO:1183, SEQ ID NO:1184, SEQ ID
SEQ ID NO: 1187, SEQ ID NO: 1188, SEQ ID
SEQ ID NO: 1191, SEQ ID NO:1192, SEQ ID
SEQ ID NO: 1195, SEQ ID NO: 1196, SEQ ID
SEQ ID NO: 1199, SEQ ID NO: 1200, SEQ ID
SEQ ID NO: 1203, SEQ ID NO:1204, SEQ ID
SEQ ID NO: 1207, SEQ ID NO: 1208, SEQ ID
SEQ ID NO: 1211, SEQ ID NO: 1212, SEQ ID
SEQ ID NO: 1215, SEQ ID NO: 1216, SEQ ID
SEQ ID NO: 1219, SEQ ID NO: 1220, SEQ ID
SEQ ID NO: 1223, SEQ ID NO: 1224, SEQ ID
SEQ ID NO: 1227, SEQ ID NO: 1228, SEQ ID
SEQ ID NO: 1231, SEQ ID NO: 1232, SEQ ID
SEQ ID NO: 1235, SEQ ID NO: 1236, SEQ ID
SEQ ID NO: 1239, SEQ ID NO: 1240, SEQ ID
SEQ ID NO: 1243, SEQ ID NO: 1244, SEQ ID
SEQ ID NO: 1247, SEQ ID NO: 1248, SEQ ID
SEQ ID NO: 1251, SEQ ID NO: 1252, SEQ ID
SEQ ID NO: 1255, SEQ ID NO: 1256, SEQ ID
SEQ ID NO: 1259, SEQ ID NO: 1260, SEQ ID

20

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NO:1261, SEQ ID NO:1262,
NO: 1265, SEQ ID NO: 1266,
NO: 1269, SEQ ID NO: 1270,
NO: 1273, SEQ ID NO: 1274,
5 NO: 1277, SEQ ID NO: 1278,

NO: 1281, SEQ ID NO: 1282,
NO: 1285, SEQ ID NO: 1286,
NO: 1289, SEQ ID NO: 1290,
NO: 1293, SEQ ID NO: 1294,

10 NO: 1297, SEQ ID NO: 1298,

NO: 1301, SEQ ID NO: 1302,
NO: 1305, SEQ ID NO: 1306,
NO: 1309, SEQ ID NO: 13 10,
NO:1313, SEQ ID NO:1314,

15 NO:1317, SEQ ID NO:1318,

NO: 1321, SEQ ID NO: 1322,
NO: 1325, SEQ ID NO: 1326,
NO: 1329, SEQ ID NO: 1330,
NO: 1333, SEQ ID NO: 1334,

20 NO: 1337, SEQ ID NO: 1338,

NO: 1341, SEQ ID NO: 1342,
NO: 1345, SEQ ID NO: 1346,
NO: 1349, SEQ ID NO: 1350,
NO: 1353, SEQ ID NO: 1354,

25 NO: 1357, SEQ ID NO: 1358,

NO: 1361, SEQ ID NO: 1362,
NO: 1365, SEQ ID NO: 1366,
NO: 1369, SEQ ID NO: 1370,
NO: 1373, SEQ ID NO: 1374,

3 0 NO: 1377, SEQ ID NO: 1378,

NO: 1381, SEQ ID NO: 1382,
NO: 1385, SEQ ID NO: 1386,
NO: 1389, SEQ ID NO: 1390,
NO: 1393, SEQ ID NO: 1394,

SEQ ID NO: 1263, SEQ ID NO: 1264, SEQ ID
SEQ ID NO: 1267, SEQ ID NO: 1268, SEQ ID
SEQ ID NO: 1271, SEQ ID NO: 1272, SEQ ID
SEQ ID NO: 1275, SEQ ID NO: 1276, SEQ ID
SEQ ID NO: 1279, SEQ ID NO: 1280, SEQ ID
SEQ ID NO: 1283, SEQ ID NO:1284, SEQ ID
SEQ ID NO: 1287, SEQ ID NO: 1288, SEQ ID
SEQ ID NO: 1291, SEQ ID NO: 1292, SEQ ID
SEQ ID NO: 1295, SEQ ID NO: 1296, SEQ ID
SEQ ID NO: 1299, SEQ ID NO: 1300, SEQ ID
SEQ ID NO: 1303, SEQ ID NO: 1304, SEQ ID
SEQ ID NO: 1307, SEQ ID NO: 1308, SEQ ID
SEQ ID NO: 1311, SEQ ID NO: 13 12, SEQ ID
SEQ ID NO: 13 15, SEQ ID NO: 1316, SEQ ID
SEQ ID NO: 13 19, SEQ ID NO: 1320, SEQ ID
SEQ ID NO: 1323, SEQ ID NO: 1324, SEQ ID
SEQ ID NO: 1327, SEQ ID NO: 1328, SEQ ID
SEQ ID NO: 1331, SEQ ID NO: 1332, SEQ ID
SEQ ID NO: 1335, SEQ ID NO: 1336, SEQ ID
SEQ ID NO: 1339, SEQ ID NO: 1340, SEQ ID
SEQ ID NO: 1343, SEQ ID NO: 1344, SEQ ID
SEQ ID NO: 1347, SEQ ID NO: 1348, SEQ ID
SEQ ID NO:1351, SEQ ID NO:1352, SEQ ID
SEQ ID NO: 1355, SEQ ID NO: 1356, SEQ ID
SEQ ID NO: 1359, SEQ ID NO: 1360, SEQ ID
SEQ ID NO: 1363, SEQ ID NO:1364, SEQ ID
SEQ ID NO: 1367, SEQ ID NO: 1368, SEQ ID
SEQ ID NO: 1371, SEQ ID NO: 1372, SEQ ID
SEQ ID NO: 1375, SEQ ID NO: 1376, SEQ ID
SEQ ID NO: 1379, SEQ ID NO: 1380, SEQ ID
SEQ ID NO: 1383, SEQ ID NO: 1384, SEQ ID
SEQ ID NO: 1387, SEQ ID NO: 1388, SEQ ID
SEQ ID NO: 1391, SEQ ID NO: 1392, SEQ ID
SEQ ID NO: 1395, SEQ ID NO: 1396, SEQ ID

21

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NO: 1397, SEQ ID NO: 1398, SEQ ID NO: 1399, SEQ ID NO: 1400, SEQ ID
NO: 1401, SEQ ID NO:1402, SEQ ID NO:1403, SEQ ID NO:1404. SEQ ID
NO: 1405, SEQ ID NO: 1406, SEQ ID NO: 1407, SEQ ID NO: 1408, SEQ ID
NO:1409, SEQ ID NO:1410, SEQ ID NO:1411, SEQ ID NO:1412, SEQ ID
5 NO: 1413, SEQ ID NO: 1414, SEQ ID NO: 1415, SEQ ID NO: 1416, SEQ ID

NO: 1417, SEQ ID NO: 1418, SEQ ID NO: 1419, SEQ ID NO: 1420, SEQ ID
NO: 1421, SEQ ID NO: 1422, SEQ ID NO: 1423, SEQ ID NO: 1424, SEQ ID
NO: 1425, SEQ ID NO: 1426, SEQ ID NO: 1427, SEQ ID NO: 1428, SEQ ID
NO: 1429, SEQ ID NO: 1430, SEQ ID NO: 1431, SEQ ID NO: 1432, SEQ ID

10 NO: 1433, SEQ ID NO: 1434, SEQ ID NO: 1435, SEQ ID NO: 1436, SEQ ID

NO: 1437, SEQ ID NO: 1438, SEQ ID NO: 1439, SEQ ID NO: 1440, SEQ ID
NO: 1441, SEQ ID NO: 1442, SEQ ID NO: 1443, SEQ ID NO: 1444, SEQ ID
NO: 1445, SEQ ID NO: 1446, SEQ ID NO: 1447, SEQ ID NO: 1448, SEQ ID
NO: 1449, SEQ ID NO:1450, SEQ ID NO: 1451, SEQ ID NO: 1452, SEQ ID

15 NO: 1453, SEQ ID NO: 1454, SEQ ID NO: 1455, SEQ ID NO: 1456, SEQ ID

NO: 1457, SEQ ID NO: 1458, SEQ ID NO: 1459, SEQ ID NO: 1460, SEQ ID
NO: 1461, SEQ ID NO: 1462, SEQ ID NO: 1463, SEQ ID NO: 1464, SEQ ID
NO: 1465, SEQ ID NO: 1466, SEQ ID NO: 1467, SEQ ID NO: 1468, SEQ ID
NO: 1469, SEQ ID NO: 1470, SEQ ID NO: 1471, SEQ ID NO: 1472, SEQ ID

2 0 NO: 1473, SEQ ID NO: 1474, SEQ ID NO: 1475, SEQ ID NO: 1476, SEQ ID

NO: 1477, SEQ ID NO: 1478, SEQ ID NO: 1479, SEQ ID NO: 1480, SEQ ID
NO: 1481, SEQ ID NO: 1482, SEQ ID NO: 1483, SEQ ID NO: 1484, SEQ ID
NO: 1485, SEQ ID NO: 1486, SEQ ID NO: 1487, SEQ ID NO: 1488, SEQ ID
NO: 1489, SEQ ID NO: 1490, SEQ ID NO: 1491, SEQ ID NO: 1492, SEQ ID

25 NO:1493, SEQ ID NO:1494, SEQ ID NO:1495, SEQ ID NO:1496, SEQ ID

NO: 1497, SEQ ID NO: 1498, SEQ ID NO: 1499, SEQ ID NO: 1500, SEQ ID
NO: 1501, SEQ ID NO:1502, SEQ ID NO: 1503, SEQ ID NO:1504, SEQ ID
NO: 1505, SEQ ID NO: 1506, SEQ ID NO: 1507, SEQ ID NO: 1508, SEQ ID
NO:1509, SEQ ID NO:1510, SEQ ID NO:1511, SEQ ID NO: 15 12, SEQ ID

30 NO:1513, SEQ ID NO:1514, SEQ ID NO:1515, SEQ ID NO:1516, SEQ ID

NO: 1517, SEQ ID NO: 1518, and SEQ ID NO: 1519;
or a complement of said sequence.

In further embodiments, the present invention provides an isolated polynucleotide
consisting essentially of a nucleotide sequence selected from the group consisting of:

22

WO 98/45437 PCT/US98/06956

SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ
ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID
NO: IK SEQ ID NO: 12. SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ
ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO:20, SEQ
5 ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ

ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO;29, SEQ ID NO:30, SEQ
ID NO:31 . SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ
ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ
ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ

10 ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ

ID NO:51, SEQ ID NO:52, SEQ ID NO:53 t SEQ ID NO:54, SEQ ID NO:55, SEQ
ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ
ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ
ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ

15 ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ

ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ
ID NO:81 , SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ
ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ
ID NO:91 , SEQ ID NO:92 t SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ

2 0 ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO: 100,

SEQ ID NO:101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID
NO: 105, SEQ ID NO: 106, SEQ ID NO: 107, SEQ ID NO: 108, SEQ ID NO: 109,
SEQ ID NO: 1 10, SEQ ID NO: 1 1 1 , SEQ ID NO: 1 12, SEQ ID NO: 1 13, SEQ ID
NO: 114, SEQ ID NO: 115, SEQ ID NO: 116, SEQ ID NO: 117, SEQ ID NO: 118,
25 SEQ ID NO:119, SEQ ID NO:120, SEQ ID NO:121, SEQ ID NO:122, SEQ ID

NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 127,
SEQ ID NO:128, SEQ ID NO:129, SEQ ID NO:130, SEQ ID NO:131, SEQ ID
NO:132, SEQ ID NO:133, SEQ ID NO:134, SEQ ID NO:135, SEQ ID NO:136,
SEQ ID NO:137, SEQ ID NO:138, SEQ ID NO:139, SEQ ID NO:140, SEQ ID

3 0 NO: 141, SEQ ID NO: 142, SEQ ID NO: 143, SEQ ID NO: 144, SEQ ID NO: 145,

SEQ ID NO: 146, SEQ ID NO: 147, SEQ ID NO: 148, SEQ ID NO: 149, SEQ ID
NO:150, SEQ ID NO:151, SEQ ID NO:152, SEQ ID NO:153, SEQ ID NO:154,
SEQ ID NO: 155, SEQ ID NO: 156, SEQ ID NO: 157, SEQ ID NO: 158, SEQ ID
NO: 159, SEQ ID NO: 160, SEQ ID NO: 161, SEQ ID NO: 162, SEQ ID NO: 163,

23

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SEQ ID NO; 164, SEQ ID NO; 165, SEQ ID NO: 166. SEQ ID NO: 167, SEQ ID
NO: 168, SEQ ID NO: 169, SEQ ID NO: 170, SEQ ID NO: 171, SEQ ID NO: 172,
SEQ ID NO: 173, SEQ ID NO: 174, SEQ ID NO: 175, SEQ ID NO: 176, SEQ ID
NO: 177, SEQ ID NO: 178, SEQ ID NO: 179, SEQ ID NO: 180, SEQ ID NO: 181 ,
5 SEQ ID NO: 182, SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO: 185, SEQ ID

NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, SEQ ID NO: 189, SEQ ID NO: 190,
SEQ ID NO: 191, SEQ ID NO: 192, SEQ ID NO: 193, SEQ ID NO: 194, SEQ ID
NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199,
SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID.NO:203, SEQ ID

10 NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208,

SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:2il, SEQ ID NO:212, SEQ ID
NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217,
SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID
NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226,

15 SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID

NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235,
SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238, SEQ ID NO:239, SEQ ID
NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244,
SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:247, SEQ ID NO;248, SEQ ID

2 0 NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253,

SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID
NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:261, SEQ ID NO:262,
SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID
NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271,
25 SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275, SEQ ID

NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280,
SEQ ID NO:281, SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID
NO:285, SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289,
SEQ ID NO:290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID NO:293, SEQ ID

3 0 NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298,

SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO:301, SEQ ID NO:302, SEQ ID
NO:303, SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307,
SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:310, SEQ ID NO:311, SEQ ID
NO:312, SEQ ID NO:313, SEQ ID NO:314, SEQ ID NO:315, SEQ ID NO:316,

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SEQ ID NO:317, SEQ ID NO:318, SEQ ID NO:319, SEQ ID NO: 320, SEQ ID
NO:321, SEQ ID NO:322, SEQ ID NO:323, SEQ ID NO:324, SEQ ID NO:325,
SEQ ID NO:326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID
NO:330,SEQID NO:331,SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334,
5 SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO:338, SEQ ID

NO:339, SEQ ID NO:340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO:343,
SEQ ID NO:344, SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID
NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352,
SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356, SEQ ID

10 NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO:360, SEQ ID NO:361,

SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID
NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369 t SEQ ID NO:370,
SEQ ID NO:371 f SEQ ID NO:372 7 SEQ ID NO:373, SEQ ID NO:374, SEQ ID
NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379,

15 SEQ ID NO:380, SEQ ID NO:381, SEQ ID NO:382, SEQ ID NO:383, SEQ ID

NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388,
SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:39l, SEQ ID NO:392, SEQ ID
NO:393, SEQ ID NO: 394, SEQ ID NO:395, SEQ ID NO:396 t SEQ ID NO:397,
SEQ ID NO:398, SEQ ID NO:399, SEQ ID NO:400, SEQ ID NO:401, SEQ ID

2 0 NO:402, SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406,

SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410, SEQ ID
NQ:411, SEQ ID NO:412, SEQ ID NO:4i3, SEQ ID NO:414, SEQ ID NO:415,
SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418, SEQ ID NO:419, SEQ ID
NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424,
25 SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428, SEQ ID

NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433,
SEQ ID NO:434, SEQ ID NO:435, SEQ ID NO:436, SEQ ID NO:437, SEQ ID
NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441, SEQ ID NO:442,
SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446, SEQ ID

3 0 NO:447, SEQ ID NO:448, SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451,

SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID
NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO:459, SEQ ID NO:460,
SEQ ID NO:461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO:464, SEQ ID
NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469,

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SEQ ID NO:470, SEQ ID NO:471, SEQ ID NO:472, SEQ ID NO:473, SEQ ID
NO:474, SEQ ID NO:475, SEQ ID NO:476, SEQ ID NO:477, SEQ ID NO:478,
SEQ ID NO:479, SEQ ID NO:480, SEQ ID NO:481, SEQ ID NO:482, SEQ ID
NO:483, SEQ ID NO;484, SEQ ID NO:485, SEQ ID NO:486, SEQ ID NO:487,
5 SEQ ID NO:488, SEQ ID NO:489, SEQ ID NO:490, SEQ ID NO:491, SEQ ID

NO:492, SEQ ID NO:493, SEQ ID NO:494, SEQ ID NO:495, SEQ ID NO:496,
SEQ ID NO:497, SEQ ID NO:498, SEQ ID NO:499, SEQ ID NO:500, SEQ ID
NO:501, SEQ ID NO:502, SEQ ID NO:503, SEQ ID NO:504, SEQ ID NO:505 t
SEQ ID NO:506, SEQ ID NO:507, SEQ ID NO:508, SEQ ID NO:509, SEQ ID

10 NO:510, SEQ ID N0:511, SEQ ID NO:5i2 > SEQ ID NO:513 t SEQ ID NO:514,

SEQ ID NO:515, SEQ ID NO:516, SEQ ID NO:517, SEQ ID NO:518, SEQ ID
NO:519, SEQ ID NO:520, SEQ ID NO:521, SEQ ID NO:522, SEQ ID NO:523,
SEQ ID NO:524, SEQ ID NO:525 t SEQ ID NO:526, SEQ ID NO:527, SEQ ID
NO:528, SEQ ID NO:529, SEQ ID NO:530, SEQ ID NO:531, SEQ ID NO:532,

15 SEQ ID NO:533, SEQ ID NO:534, SEQ ID NO:535, SEQ ID NO:536, SEQ ID

NO:537, SEQ ID NO:538, SEQ ID NO:539, SEQ ID NO:540, SEQ ID NO:541,
SEQ ID NO:542, SEQ ID NO:543, SEQ ID NO:544, SEQ ID NO:545, SEQ ID
NO:546, SEQ ID NO:547, SEQ ID NO:548, SEQ ID NO:549, SEQ ID NO:550,
SEQ ID NO:551, SEQ ID NO:5S2, SEQ ID NO:553, SEQ ID NO:554, SEQ ID

20 NO:555, SEQ ID NO:556, SEQ ID NO:557, SEQ ID NO:558, SEQ ID NO:559,

SEQ ID NO:560, SEQ ID NO:561, SEQ ID NO:562, SEQ ID NO:563 t SEQ ID
NO:564 t SEQ ID NO:565, SEQ ID NO:566, SEQ ID NO:567, SEQ ID NO:568,
SEQ ID NO:569, SEQ ID NO:570, SEQ ID NO:571, SEQ ID NO:572, SEQ ID
NO:573, SEQ ID NO:574, SEQ ID NO:575, SEQ ID NO:576, SEQ ID NO:577,

2 5 SEQ ID NO:578, SEQ ID NO:579, SEQ ID NO:580 T SEQ ID NO:581, SEQ ID

NO:582, SEQ ID NO:583, SEQ ID NO:584, SEQ ID NO:585, SEQ ID NO:586,
SEQ ID NO:587, SEQ ID NO:588, SEQ ID NO:589, SEQ ID NO:590, SEQ ID
NO:591, SEQ ID NO:592, SEQ ID NO:593, SEQ ID NO:594, SEQ ID NO:595,
SEQ ID NO:596, SEQ ID NO:597, SEQ ID NO:598, SEQ ID NC:599, SEQ ID

3 0 NO:600, SEQ ID NO:601 , SEQ ID NO:602, SEQ ID NO:603, SEQ ID NO:604,

SEQ ID NO:605, SEQ ID NO:606, SEQ ID NO:607, SEQ ID NO:608, SEQ ID
NO:609, SEQ ID NO:610, SEQ ID NO:61 1, SEQ ID NO:612, SEQ ID NO:613,
SEQ ID NO:614, SEQ ID NO:615, SEQ ID NO:616, SEQ ID NO:617, SEQ ID
NO:618, SEQ ID NO:619, SEQ ID NO:620, SEQ ID NO:621, SEQ ID NO:622,

26

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SEQ ID NO:623. SEQ ID NO;624, SEQ ID NO:625, SEQ ID NO;626, SEQ ID
NO.627, SEQ ID NO:628, SEQ ID NO:629. SEQ ID NO:630, SEQ ID NO:631,
SEQ ID NO:632, SEQ ID NO:633, SEQ ID NO:634, SEQ ID NO:635, SEQ ID
NO:636, SEQ ID NO:637, SEQ ID NO:638, SEQ ID NO:639, SEQ ID NO:640,
5 SEQ ID NO:64i v SEQ ID NO:642, SEQ ID NO:643, SEQ ID NO:644, SEQ ID

NO:645, SEQ ID NO:646, SEQ ID NO:647, SEQ ID NO:648, SEQ ID NO:649,
SEQ ID NO:650, SEQ ID NO:651, SEQ ID NO:652, SEQ ID NO:653, SEQ ID
NO:654, SEQ ID NO:655, SEQ ID NO:656, SEQ ID NO:657, SEQ ID NO;658,
SEQ ID NO:659, SEQ ID NO:660, SEQ ID NO:661, SEQ ID NO:662, SEQ ID

10 NO:663, SEQ ID NO:664, SEQ ID NO:665, SEQ ID NO:666, SEQ ID NO:667,

SEQ ID NO:668, SEQ ID NO:669, SEQ ID NO:670, SEQ ID NO:671, SEQ ID
NO:672, SEQ ID NO:673, SEQ ID NO:674, SEQ ID NO:675, SEQ ID NO;676,
SEQ ID NO:677, SEQ ID NO:678, SEQ ID NO:679, SEQ ID NO:680, SEQ ID
NO:681, SEQ ID NO:682, SEQ ID NO:683, SEQ ID NO:684, SEQ ID NO:685,

15 SEQ ID NO:686, SEQ ID NO:687, SEQ ID NO:688, SEQ ID NO:689 > SEQ ID

NO:690, SEQ ID NO:691, SEQ ID NO:692 ? SEQ ID NO:693, SEQ ID NO:694,
SEQ ID NO:695, SEQ ID NO:696, SEQ ID NO:697, SEQ ID NO:698, SEQ ID
NO:699, SEQ ID NO:700, SEQ ID NO:701. SEQ ID NO:702, SEQ ID NO:703,
SEQ ID NO:704, SEQ ID NO:705, SEQ ID NO:706, SEQ ID NO:707, SEQ ID

20 NO;708, SEQ ID NO:709, SEQ ID NO:7I0, SEQ ID N0:711, SEQ ID NO:712,

SEQ ID NO:713, SEQ ID NO:714, SEQ ID NO:715, SEQ ID NO:716 t SEQ ID
NO:717, SEQ ID NO:718, SEQ ID NO:719, SEQ ID NO:720, SEQ ID NO:721,
SEQ ID NO:722, SEQ ID NO:723, SEQ ID NO:724, SEQ ID NO:725, SEQ ID
NO:726, SEQ ID NO:727, SEQ ID NO:728, SEQ ID NO:729, SEQ ID NO:730,

25 SEQ ID NO:731, SEQ ID NO:732> SEQ ID NO:733, SEQ ID NO:734, SEQ ID

NO:735, SEQ ID NO:736, SEQ ID NO:737, SEQ ID NO:738, SEQ ID NO:739,
SEQ ID NO:740, SEQ ID NO:741, SEQ ID NO:742, SEQ ID NO:743, SEQ ID
NO:744, SEQ ID NO:745, SEQ ID NO:746, SEQ ID NO;747, SEQ ID NO:748>
SEQ ID NO:749, SEQ ID NO:750, SEQ ID NO:751, SEQ ID NO:752, SEQ ID

3 0 NO:753, SEQ ID NO:754, SEQ ID NO:755, SEQ ID NO:756, SEQ ID NO:757,

SEQ ID NO:758, SEQ ID NO:759, SEQ ID NO:760, SEQ ID NO:761, SEQ ID
NO:762, SEQ ID NO:763, SEQ ID NO:764, SEQ ID NO: 765, SEQ ID NO:766,
SEQ ID NO:767, SEQ ID NO:768, SEQ ID NO:769, SEQ ID NO:770, SEQ ID
NO-.771, SEQ ID NO:772, SEQ ID NO:773, SEQ ID NO:774, SEQ ID NO:775,

27

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SEQ ID NO;776, SEQ ID NO:777, SEQ ID NO:778, SEQ ID NO:779, SEQ ID
NO:780, SEQ ID NO:78L SEQ ID NO:782, SEQ ID NO:783, SEQ ID NO:784,
SEQ ID NO:785, SEQ ID NO:786, SEQ ID NO:787, SEQ ID NO:788, SEQ ID
NO:789, SEQ ID NO:790, SEQ ID NO:791, SEQ ID NO:792, SEQ ID NO:793,
5 SEQ ID NO:794, SEQ ID NO:795, SEQ ID NO:796, SEQ ID NO:797, SEQ ID

NO:798, SEQ ID NO:799, SEQ ID NO:800, SEQ ID NO:801, SEQ ID NO: 802,
SEQ ID NO:803, SEQ ID NO:804, SEQ ID NO:805, SEQ ID NO:806, SEQ ID
NO;807, SEQ ID NO;808, SEQ ID NO:809, SEQ ID NO:810, SEQ ID N0:811,
SEQ ID NO:812, SEQ ID NO:813, SEQ ID NO:814, SEQ ID NO:815, SEQ ID

10 NO:816, SEQ ID NO:817, SEQ ID NO:818, SEQ ID NO.819, SEQ ID NO:820,

SEQ ID NO:821, SEQ ID NO:822 t SEQ ID NO:823, SEQ ID NO:824, SEQ ID
NO:825, SEQ ID NO:826, SEQ ID NO: 827 /SEQ ID NO:828, SEQ ID NO:829,
SEQ ID NO:830, SEQ ID NO:831, SEQ ID NO:832, SEQ ID NO:833, SEQ ID
NO:834, SEQ ID NO:835, SEQ ID NO:836, SEQ ID NO:837, SEQ ID NO:838,

15 SEQ ID NO:839, SEQ ID NO:840, SEQ ID NO:841, SEQ ID NO:842, SEQ ID

NO:843, SEQ ID NO:844 t SEQ ID NO:845, SEQ ID NO:846, SEQ ID NO:847,
SEQ ID NO:848, SEQ ID NO:849, SEQ ID NO:850, SEQ ID NO:851, SEQ ID
NO:852, SEQ ID NO:853, SEQ ID NO:854, SEQ ID NO:855, SEQ ID NO:856,
SEQ ID NO:857, SEQ ID NO:858, SEQ ID NO:859, SEQ ID NO.860, SEQ ID

20 NO:861, SEQ ID NO:862, SEQ ID NO:863, SEQ ID NO:864, SEQ ID NO:865,

SEQ ID NO:866, SEQ ID NO:867 t SEQ ID NO:868, SEQ ID NO:869, SEQ ID
NO:870, SEQ ID NO:871, SEQ ID NO:872, SEQ ID NO:873, SEQ ID NO:874,
SEQ ID NO:875, SEQ ID NO:876, SEQ ID NO-.877, SEQ ID NO:878, SEQ ID
NO:879, SEQ ID NO:880 ? SEQ ID NO:881, SEQ ID NO:882, SEQ ID NO:883,

25 SEQ ID NO:884, SEQ ID NO:885, SEQ ID NO:886, SEQ ID NO:887, SEQ ID

NO:888, SEQ ID NO:889, SEQ ID NO:890, SEQ ID NO:891, SEQ ID NO:892,
SEQ ID NO:893, SEQ ID NO:894, SEQ ID NO:895, SEQ ID NO:896, SEQ ID
NO:897, SEQ ID NO:898, SEQ ID NO:899, SEQ ID NO:900, SEQ ID NO:901,
SEQ ID NO:902, SEQ ID NO:903, SEQ ID NO:904, SEQ ID NO:905, SEQ ID

3 0 NO:906, SEQ ID NO:907, SEQ ID NO:908, SEQ ID NO:909, SEQ ID NO:910,

SEQ ID NO:911, SEQ ID NO:912, SEQ ID NO:913, SEQ ID NO:914, SEQ ID
NO:915, SEQ ID NO:916, SEQ ID NO:9I7, SEQ ID NO:918, SEQ ID NO:929,
SEQ ID NO:920, SEQ ID NO:921, SEQ ID NO:922, SEQ ID NO:923, SEQ ID
NO:924, SEQ ID NO:925, SEQ ID NO:926, SEQ ID NO:927, SEQ ID NO:928,

28

WO 98/45437

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SEQ ID NO:929, SEQ ID NO:930, SEQ ID NO:93i, SEQ ID NO:932, SEQ ID
NO:933, SEQ ID NO:934, SEQ ID NO:935, SEQ ID NO:936, SEQ ID NO:937,
SEQ ID NO:938, SEQ ID NO:939, SEQ ID NO:940, SEQ ID NO:941, SEQ ID
NO:942, SEQ ID NO:943, SEQ ID NO:944, SEQ ID NO:945, SEQ ID NO:946,
5 SEQ ID NO:947, SEQ ID NO;948, SEQ ID NO:949, SEQ ID NO:950, SEQ ID

NO:951, SEQ ID NO:952, SEQ ID NO:953, SEQ ID NO:954, SEQ ID NO:955,
SEQ ID NO:956, SEQ ID NO:957, SEQ ID NO:958, SEQ ID NO:959, SEQ ID
NO:960, SEQ ID NO:961, SEQ ID NO:962, SEQ ID NO:963, SEQ ID NO:964,
SEQ ID NO:965, SEQ ID NO;966, SEQ ID NO:967, SEQ ID NO:968, SEQ ID

10 NO:969, SEQ ID NO:970, SEQ ID NO:971, SEQ ID NO:972, SEQ ID NO:973,

SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:976, SEQ ID NO:977, SEQ ID
NO:978, SEQ ID NO:979, SEQ ID NO:980, SEQ ID NO:981, SEQ ID NO:982,
SEQ ID NO:983, SEQ ID NO:984, SEQ ID NO:985, SEQ ID NO:986, SEQ ID
NO:987, SEQ ID NO:988, SEQ ID NO:989, SEQ ID NO:990, SEQ ID NO:991,

15 SEQ ID NO:992, SEQ ID NO:993, SEQ ID NO:994, SEQ ID NO:995, SEQ ID

NO:996, SEQ ID NO:997, SEQ ID NO:998, SEQ ID NO;999, SEQ ID NO: 1000,
SEQ ID NO: 1001 , SEQ ID NO: 1002, SEQ ID NO: 1003, SEQ ID NO: 1004, SEQ
ID NO: 1005, SEQ ID NO: 1006, SEQ ID NO: 1007, SEQ ID NO: 1008, SEQ ID
NO: 1009, SEQ ID NO: 1010, SEQ ID NO: 1011, SEQ ID NO:1012, SEQ ID

2 0 NO: 1013, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1016, SEQ ID

NO: 1017, SEQ ID NO: 1018, SEQ ID NO: 1019, SEQ ID NO: 1020, SEQ ID
NO: 1021, SEQ ID NO: 1022, SEQ ID NO: 1023, SEQ ID NO:1024, SEQ ID
NO: 1025, SEQ ID NO: 1026, SEQ ID NO: 1027, SEQ ID NO: 1028, SEQ ID
NO: 1029, SEQ ID NO: 1030, SEQ ID NO: 1031, SEQ ID NO: 1032, SEQ ID
25 NO:1033, SEQ ID NO:1034, SEQ ID NO:1035, SEQ ID NO:1036, SEQ ID

NO:1037, SEQ ID NO:1038, SEQ ID NO: 1039, SEQ ID NO:1040, SEQ ID
NO: 1041, SEQ ID NO:1042, SEQ ID NO: 1043, SEQ ID NO:1044, SEQ ID
NO: 1045, SEQ ID NO: 1046, SEQ ID NO: 1047, SEQ ID NO: 1048, SEQ ID
NO:1049, SEQ ID NO:1050, SEQ ID NO: 1051, SEQ ID NO:1052, SEQ ID

3 0 NO: 1053, SEQ ID NO: 1054, SEQ ID NO: 1055, SEQ ID NO: 1056, SEQ ID

NO: 1057, SEQ ID NO: 1058, SEQ ID NO: 1059, SEQ ID NO: 1060, SEQ ID
NO: 1061, SEQ ID NO: 1062, SEQ ID NO: 1063, SEQ ID NO: 1064, SEQ ID
NO: 1065, SEQ ID NO: 1066, SEQ ID NO: 1067, SEQ ID NO: 1068, SEQ ID
NO: 1069, SEQ ID NO: 1070, SEQ ID NO: 1071, SEQ ID NO: 1072, SEQ ID

WO 98/45437

PCT/US98/06956

NO: 1073, SEQ ID NO: 1074,
NO: 1077, SEQ ID NO: 1078,
NO: 1081, SEQ ID NO: 1082,
NO: 1085, SEQ ID NO: 1086,
5 NO: 1089, SEQ ID NO: 1090,

NO: 1093, SEQ ID NO: 1094,
NO: 1097, SEQ ID NO: 1098,
NO: 1101, SEQ ID NO: 1102,
NO: 1105, SEQ ID NO: 1106,

10 NO: 1109, SEQ ID NO: 1 110,

NO: 11 13, SEQ ID NO: 11 14,
NO: 11 17, SEQ ID NO: 11 18,
NO:1121, SEQ ID NO: 1122,
NO: 1125, SEQ ID NO: 1126,

15 NO: 1129, SEQ ID NO: 1130,

NO: 1133, SEQ ID NO: 1134,
NO: 1137, SEQ ID NO: 1138,
NO: 1141, SEQ ID NO: 1142,
NO: 1145, SEQ ID NO: 1146,

20 NO: 1149, SEQ ID NO: 1150,

NO: 1153, SEQ ID NO: 1154,
NO: 1157, SEQ ID NO: 1158,
NO: 1161, SEQ ID NO: 1162,
NO: 1165, SEQ ID NO: 1166,

25 NO: 1169, SEQ ID NO: 1170,

NO: 1173, SEQ ID NO: 1174,
NO: 1177, SEQ ID NO: 1178,
NO: 1181, SEQ ID NO: 1182,
NO: 1185, SEQ ID NO: 11 86,

3 0 NO: 1189, SEQ ID NO: 1190,

NO:1193, SEQ ID NO:1194,
NO: 1197, SEQ ID NO: 1198,
NO: 1201, SEQ ID NO: 1202,
NO: 1205, SEQ ID NO: 1206,

SEQ ID NO: 1075, SEQ ID NO: 1076, SEQ ID
SEQ ID NO: 1079, SEQ ID NO: 1080, SEQ ID
SEQ ID NO: 1083, SEQ ID NO: 1084, SEQ ID
SEQ ID NO: 1087, SEQ ID NO: 1088, SEQ ID
SEQ ID NO: 1091, SEQ ID NO: 1092, SEQ ID
SEQ ID NO: 1095, SEQ ID NO: 1096, SEQ ID
SEQ ID NO: 1099, SEQ ID NO: 1100, SEQ ID
SEQ ID NO: 1103, SEQ ID NO: 1104, SEQ ID
SEQ ID NO: 1107, SEQ ID NO: 1108, SEQ ID
SEQ ID NO: 1111, SEQ ID NO: 11 12, SEQ ID
SEQ ID NO.1115, SEQ ID NO:1116, SEQ ID
SEQ ID NO: 11 19, SEQ ID NO: 1120, SEQ ID
SEQ ID NO: 1123, SEQ ID NO: 1124, SEQ ID
SEQ ID NO: 1127, SEQ ID NO: 1128, SEQ ID
SEQ ID NO: 1131, SEQ ID NO: 1132, SEQ ID
SEQ ID NO: 1135, SEQ ID NO: 1136, SEQ ID
SEQ ID NO:1139, SEQ ID NO: 1140, SEQ ID
SEQ ID NO: 1143, SEQ ID NO: 1144, SEQ ID
SEQ ID NO: 1147, SEQ ID NO: 1148, SEQ ID
SEQ ID NO: 1151, SEQ ID NO: 1152, SEQ ID
SEQ ID NO: 1155, SEQ ID NO: 1156, SEQ ID
SEQ ID NO: 1159, SEQ ID NO: 1160, SEQ ID
SEQ ID NO: 1163, SEQ ID NO: 1164, SEQ ID
SEQ ID NO: 1167, SEQ ID NO: 11 68, SEQ ID
SEQ ID NO: 1171, SEQ ID NO: 1172, SEQ ID
SEQ ID NO: 1175, SEQ ID NO: 1176, SEQ ID
SEQ ID NO: 1179, SEQ ID NO: 11 80, SEQ ID
SEQ ID NO: 1183, SEQ ID NO: 11 84, SEQ ID
SEQ ID NO: 1187, SEQ ID NO: 1188, SEQ ID
SEQ ID NO: 1191, SEQ ID NO: 1192, SEQ ID
SEQ ID NO:1195, SEQ ID NO:1196, SEQ ID
SEQ ID NO: 11 99, SEQ ID NO: 1200, SEQ ID
SEQ ID NO: 1203, SEQ ID NO: 1204, SEQ ID
SEQ ID NO: 1207, SEQ ID NO: 1208, SEQ ID

30

PCT/US98/06956

NO: 1209, SEQ ID NO: 1210, SEQ ID
NO: 1213, SEQ ID NO: 1214, SEQ ID
NO: 1217, SEQ ID NO: 1218, SEQ ID
NO: 1221, SEQ ID NO: 1222, SEQ ID
NO: 1225, SEQ ID NO: 1226, SEQ ID
NO: 1229, SEQ ID NO: 1230, SEQ ID
NO: 1233, SEQ ID NO: 1234, SEQ ID
NO: 1237, SEQ ID NO: 1238, SEQ ID
NO: 1241, SEQ ID NO: 1242, SEQ ID
NO: 1245, SEQ ID NO: 1246, SEQ ID
NO: 1249, SEQ ID NO: 1250, SEQ ID
NO: 1253, SEQ ID NO: 1254, SEQ ID
NO: 1257, SEQ ID NO: 1258, SEQ ID
NO: 1261, SEQ ID NO: 1262, SEQ ID
NO: 1265, SEQ ID NO: 1266, SEQ ID
NO: 1269, SEQ ID NO: 1270, SEQ ID
NO: 1273, SEQ ID NO: 1274, SEQ ID
NO: 1277, SEQ ID NO: 1278, SEQ ID
NO: 1281, SEQ ID NO: 1282, SEQ ID
NO: 1285, SEQ ID NO: 1286, SEQ ID
NO: 1289, SEQ ID NO: 1290, SEQ ID
NO: 1293, SEQ ID NO: 1294, SEQ ID
NO: 1297, SEQ ID NO: 1298, SEQ ID
NO: 1301, SEQ ID NO: 1302, SEQ ID
NO: 1305, SEQ ID NO: 1306, SEQ ID
NO: 1309, SEQ ID NO:1310, SEQ ID
NO: 13 13, SEQ ID NO: 13 14, SEQ ID
NO:1317, SEQ ID NO:1318, SEQ ID
NO:1321, SEQ ID NO:1322, SEQ ID
NO: 1325, SEQ ID NO: 1326, SEQ ID
NO: 1329, SEQ ID NO: 1330, SEQ ID
NO:1333, SEQ ID NO:1334, SEQ ID
NO: 1337, SEQ ID NO: 1338, SEQ ID
NO:1341, SEQ ID NO:1342, SEQ ID

NO: 1211, SEQ ID NO: 1212, SEQ ID
NO:1215, SEQ ID NO:I216, SEQ ID
NO: 1219, SEQ ID NO: 1220, SEQ ID
NO: 1223, SEQ ID NO: 1224, SEQ ID
NO: 1227, SEQ ID NO: 1228, SEQ ID
NO: 1231, SEQ ID NO: 1232, SEQ ID
NO: 1235, SEQ ID NO: 1236, SEQ ID
NO: 1239, SEQ ID NO: 1240, SEQ ID
NO: 1243, SEQ ID NO: 1244, SEQ ID
NO: 1247, SEQ ID NO: 1248, SEQ ID
NO: 1251, SEQ ID NO: 1252, SEQ ID
NO: 1255, SEQ ID NO: 1256, SEQ ID
NO: 1259, SEQ ID NO: 1260, SEQ ID
NO: 1263, SEQ ID NO: 1264, SEQ ID
NO: 1267, SEQ ID NO: 1268, SEQ ID
NO: 1271, SEQ ID NO: 1272, SEQ ID
NO: 1275, SEQ ID NO:1276, SEQ ID
NO: 1279, SEQ ID NO: 1280, SEQ ID
NO: 1283, SEQ ID NO: 1284, SEQ ID
NO: 1287, SEQ ID NO: 1288, SEQ ID
NO: 1291, SEQ ID NO: 1292, SEQ ID
NO: 1295, SEQ ID NO: 1296, SEQ ID
NO: 1299, SEQ ID NO: 1300, SEQ ID
NO: 1303, SEQ ID NO: 1304, SEQ ID
NO: 1307, SEQ ID NO: 1308, SEQ ID
NO:1311, SEQ ID NO: 1312, SEQ ID
NO: 13 15, SEQ ID NO: 13 16, SEQ ID
NO:1319, SEQ ID NO:1320, SEQ ID
NO:1323, SEQ ID N0:1324, SEQ ID
NO: 1327, SEQ ID NO: 1328, SEQ ID
NO: 1331, SEQ ID NO: 1332, SEQ ID
NO:1335, SEQ ID N0:1336, SEQ ID
NO: 1339, SEQ ID NO: 1340, SEQ ID
NO: 1343, SEQ ID NO: 1344, SEQ ID

31

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NO: 1345, SEQ ID NO: 1346,
NO: 1349, SEQ ID NO: 1350,
NO: 1353, SEQ ID NO: 1354,
NO: 1357, SEQ ID NO: 1358,
5 NO:1361, SEQ ID NO:1362,

NO: 1365, SEQ ID NO: 1366,
NO: 1369, SEQ ID NO: 1370,
NO: 1373, SEQ ID NO: 1374,
NO: 1377, SEQ ID NO: 1378,

10 NO:1381, ZEQ ID NO:1382,

NO: 1385, SEQ ID NO: 1386,
NO: 1389, SEQ ID NO: 1390,
NO: 1393, SEQ ID NO: 1394,
NO: 1397, SEQ ID NO: 1398,

15 NO: 1401, SEQ ID NO: 1402,

NO: 1405, SEQ ID NO: 1406,
NO: 1409, SEQ ID NO: 1410,
NO: 1413, SEQ ID NO: 1414,
NO: 1417, SEQ ID NO: 1418,

2 0 NO: 1421, SEQ ID NO: 1422,

NO: 1425, SEQ ID NO: 1426,
NO: 1429, SEQ ID NO: 1430,
NO: 1433, SEQ ID NO: 1434,
NO: 1437, SEQ ID NO: 1438,
25 NO: 1441, SEQ ID NO: 1442,

NO: 1445, SEQ ID NO: 1446,
NO: 1449, SEQ ID NO: 1450,
NO: 1453, SEQ ID NO: 1454,
NO: 1457, SEQ ID NO: 1458,

3 0 NO: 1461, SEQ ID NO: 1462,

NO: 1465, SEQ ID NO: 1466,
NO: 1469, SEQ ID NO: 1470,
NO: 1473, SEQ ID NO: 1474,
NO: 1477, SEQ ID NO: 1478,

SEQ ID NO: 1347, SEQ ID NO: 1348, SEQ ID
SEQ ID NO: 1351, SEQ ID NO: 1352, SEQ ID
SEQ ID NO: 1355, SEQ ID NO: 1356, SEQ ID
SEQ ID NO: 1359, SEQ ID NO: 1360, SEQ ID
SEQ ID NO: 1363, SEQ ID NO: 1364, SEQ ID
SEQ ID NO: 1367, SEQ ID NO: 1368, SEQ ID
SEQ ID NO: 1371, SEQ ID NO: 1372, SEQ ID
SEQ ID NO: 1375, SEQ ID NO: 1376, SEQ ID
SEQ ID NO: 1379, SEQ ID NO: 1380, SEQ ID
SEQ ID NO: 1383, SEQ ID NO: 1384, SEQ ID
SEQ ID NO: 1387, SEQ ID NO: 1388, SEQ ID
SEQ ID NO: 1391, SEQ ID NO: 1392, SEQ ID
SEQ ID NO:1395, SEQ ID NO: 1396, SEQ ID
SEQ ID NO: 1399, SEQ ID NO: 1400, SEQ ID
SEQ ID NO: 1403, SEQ ID NO: 1404, SEQ ID
SEQ ID NO: 1407, SEQ ID NO: 1408, SEQ ID
SEQ ID NO:1411, SEQ ID NO:1412, SEQ ID
SEQ ID NO:1415, SEQ ID NO:1416, SEQ ID
SEQ ID NO: 1419, SEQ ID NO: 1420, SEQ ID
SEQ ID NO: 1423, SEQ ID NO: 1424, SEQ ID
SEQ ID NO: 1427, SEQ ID NO: 1428, SEQ ID
SEQ ID NO: 1431, SEQ ID NO: 1432, SEQ ID
SEQ ID NO:1435, SEQ ID NO: 1436, SEQ ID
SEQ ID NO: 1439, SEQ ID NO: 1440, SEQ ID
SEQ ID NO: 1443, SEQ ID NO: 1444, SEQ ID
SEQ ID NO: 1447, SEQ ID NO: 1448, SEQ ID
SEQ ID NO: 1451, SEQ ID NO: 1452, SEQ ID
SEQ ID NO: 1455, SEQ ID NO: 1456, SEQ ID
SEQ ID NO: 1459, SEQ ID NO: 1460, SEQ ID
SEQ ID NO: 1463, SEQ ID NO: 1464, SEQ ID
SEQ ID NO: 1467, SEQ ID NO: 1468, SEQ ID
SEQ ID NO:1471, SEQ ID NO:1472, SEQ ID
SEQ ID NO: 1475, SEQ ID NO: 1476, SEQ ID
SEQ ID NO: 1479, SEQ ID NO: 1480, SEQ ID

32

WO 98/45437 PCT/US98/06956

NO:1481, SEQ ID NO:1482, SEQ ID NO:1483, SEQ ID NO:1484, SEQ ID
NO: 1485, SEQ ID NO: 1486, SEQ ID NO: 1487, SEQ ID NO: 1488, SEQ ID
NO: 1489, SEQ ID NO: 1490, SEQ ID NO: 1491, SEQ ID NO: 1492, SEQ ID
NO: 1493, SEQ ID NO: 1494, SEQ ID NO: 1495, SEQ ID NO: 1496, SEQ ID
5 NO: 1497, SEQ ID NO: 1498, SEQ ID NO: 1499, SEQ ID NO: 1500, SEQ ID

NO: 150 1, SEQ ID NO: 1502, SEQ ID NO: 1503, SEQ ID NO: 1504, SEQ ID
NO: 1505, SEQ ID NO: 1506, SEQ ID NO: 1507, SEQ ID NO: 1508, SEQ ID
NO:1509, SEQ ID NO: 1510, SEQ ID NO:1511, SEQ ID NO:1512, SEQ ID
NO:1513, SEQ ID NO:1514, SEQ ID NO:1515, SEQ ID NO:1516, SEQ ID
10 NO: 15 17, SEQ ID NO: 1518, and SEQ ID NO: 1519;

or a complement of said sequence.

In yet other embodiments, the present invention provides an isolated polynucleotide

comprising a nucleotide sequence which hybridizes to a sequence selected from the group

consisting of:

15 SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ

ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO: 10, SEQ ID
NO:ll, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ
ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO:20, SEQ
ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ

20 ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ

ID NO:31, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ
ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO.40, SEQ
ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ
ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ

25 ID NO:51 , SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ

ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ
ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ
ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ
ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ

3 0 ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ

ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ
ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ
ID NO:91> SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ
ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO: 100,

33

WO 98/45437 PCT/US98/06956

SEQ ID NO: 101, SEQ ID NO: 102, SEQ ID NO: 103, SEQ ID NO: 104, SEQ ID
NO: 105, SEQ ID NO: 106. SEQ ID NO: 107, SEQ ID NO: 108, SEQ ID NO: 109 t
SEQ ID NO: 110, SEQ ID NO: 111, SEQ ID NO: 112, SEQ ID NO: 113, SEQ ID
NO:114,SEQID NO: 115, SEQ ID NO: 116, SEQ ID NO: 117, SEQ ID NO:118,
5 SEQ ID NO: 1 19, SEQ ID NO: 120, SEQ ID NO: 121, SEQ ID NO: 122, SEQ ID

NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 127,
SEQ ID NO: 128, SEQ ID NO: 129, SEQ ID NO: 130, SEQ ID NO: 131, SEQ ID
NO: 132, SEQ ID NO: 133, SEQ ID NO: 134, SEQ ID NO: 135, SEQ ID NO: 136,
SEQ ID NO: 137, SEQ ID NO: 138, SEQ ID NO: 139, SEQ ID NO: 140, SEQ ID

10 NO: 141, SEQ ID NO: 142, SEQ ID NO:143, SEQ ID NO:!44, SEQ ID NO:I45,

SEQ ID NO: 146, SEQ ID NO: 147, SEQ ID NO: 148, SEQ ID NO: 149, SEQ ID
NO:150, SEQ ID NO: 151, SEQ ID NO: 152, SEQ ID NO:153, SEQ ID NO:154,
SEQ ID NO: 155, SEQ ID NO: 156, SEQ ID NO: 157, SEQ ID NO: 158, SEQ ID
NO: 159, SEQ ID NO: 160, SEQ ID NO: 161 , SEQ ID NO: 162, SEQ ID NO: 163,

15 SEQ ID NO: 164, SEQ ID NO: 165, SEQ ID NO: 166, SEQ ID NO: 167, SEQ ID

NO: 168, SEQ ID NO: 169, SEQ ID NO: 170, SEQ ID NO: 171, SEQ ID NO: 172,
SEQ ID NO: 173, SEQ ID NO: 174, SEQ ID NO: 175, SEQ ID NO: 176, SEQ ID
NO: 177, SEQ ID NO: 178, SEQ ID NO: 179, SEQ ID NO: 180, SEQ ID NO: 181,
SEQ ID NO: 182, SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO; 185, SEQ ID

20 NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, SEQ ID NO: 189, SEQ ID NO: 190,

SEQ ID NO: 191, SEQ ID NO: 192, SEQ ID NO: 193, SEQ ID NO: 194, SEQ ID
NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199,
SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID
NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208,

25 SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:211, SEQ ID NO:212, SEQ ID

N0:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217,
SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID
NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226,
SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID

30 NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235,

SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238, SEQ ID NO;239, SEQ ID
NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244,
SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:247, SEQ ID NO:248, SEQ ID
NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253,

34

WO 98/45437

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SEQ ID NO:254, SEQ ID NO;255, SEQ ID NO:256, SEQ ID NO;257, SEQ ID
NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:261, SEQ ID NO:262,
SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID
NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271,
5 SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275, SEQ ID

NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280,
SEQ ID NO:281, SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284; SEQ ID
NO:285 T SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289,
SEQ ID NO:290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID N0.293, SEQ ID

10 NO;294, SEQ ID NO:295 t SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298,

SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO:301, SEQ ID NO:302, SEQ ID
NO:303, SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307,
SEQ ID NO:308, SEQ ID NO:309 t SEQ ID NO:310, SEQ ID NO:311, SEQ ID
NO:312, SEQ ID NO:313, SEQ ID NO:314, SEQ ID NO:315 7 SEQ ID NO:316,

15 SEQ ID NO:317, SEQ ID NO:318, SEQ ID NO:319, SEQ ID NO:320, SEQ ID

NO:321, SEQ ID NO:322, SEQ ID NO:323 T SEQ ID NO:324, SEQ ID NO:325,
SEQ ID NO:326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID
NO:330, SEQ ID NO:331, SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334,
SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO:338, SEQ ID

20 NO:339, SEQ ID NO;340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO:343,

SEQ ID NO:344, SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID
NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352,
SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356, SEQ ID
NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO:360, SEQ ID NO:361,

25 SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID

NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369, SEQ ID NO:370,
SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373, SEQ ID NO:374, SEQ ID
NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379,
SEQ ID NO:380, SEQ ID NO:38l, SEQ ID NO:382, SEQ ID NO:383, SEQ ID

3 0 NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388,

SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID
NO:393, SEQ ID NO:394, SEQ ID NO:395, SEQ ID NO:396, SEQ ID NO:397,
SEQ ID NO:398, SEQ ID NO:399, SEQ ID NO:400, SEQ ID NO:401, SEQ ID
NO:402, SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406,

35

WO 98/45437

PCT/US98/06956

SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410, SEQ ID
NO:411, SEQ ID NO:412, SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415,
SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418, SEQ ID NO:419, SEQ ID
NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO;423, SEQ ID NO:424,
5 SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428, SEQ ID

NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433,
SEQ ID NO:434, SEQ ID NO:435, SEQ ID NO:436, SEQ ID NO:437, SEQ ID
NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441, SEQ ID NO:442,
SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445 t SEQ ID NO:446, SEQ ID

10 NO:447, SEQ ID NO:448, SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451,

SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID
NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO:459, SEQ ID NO:460,
SEQ ID NO:461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO:464, SEQ ID
NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469,

15 SEQ ID NO:470, SEQ ID NO;471, SEQ ID NO:472, SEQ ID NO:473, SEQ ID

NO:474, SEQ ID NO:475, SEQ ID NO:476 t SEQ ID NO:477 ? SEQ ID NO:478,
SEQ ID NO:479, SEQ ID NO:480, SEQ ID NO:481, SEQ ID NO:482, SEQ ID
NO:483, SEQ ID NO:484, SEQ ID NO:485, SEQ ID NO:486, SEQ ID NO:487,
SEQ ID NO:488, SEQ ID NO:489, SEQ ID NO:490, SEQ ID NO:491, SEQ ID

20 NO:492, SEQ ID NO:493, SEQ ID NO:494, SEQ ID NO:495, SEQ ID NO:496,

SEQ ID NO:497 T SEQ ID NO:498, SEQ ID NO:499, SEQ ID NO:500, SEQ ID
NO:501, SEQ ID NO:502, SEQ ID NO:503, SEQ ID NO:504, SEQ ID NO:505,
SEQ ID NO:506, SEQ ID NO:507, SEQ ID NO:508, SEQ ID NO:509, SEQ ID
NO:510, SEQ ID N0:511, SEQ ID NO:512, SEQ ID NO:513, SEQ ID NO:514,

2 5 SEQ ID NO:515, SEQ ID NO:516, SEQ ID NO:5I7 t SEQ ID NO:518, SEQ ID

NO:519, SEQ ID NO:520, SEQ ID NO:521, SEQ ID NO:522, SEQ ID NO:523,
SEQ ID NO:524, SEQ ID NO:525, SEQ ID NO:526, SEQ ID NO:527, SEQ ID
NO:528, SEQ ID NO:529, SEQ ID NO:530, SEQ ID NO:531, SEQ ID NO:532,
SEQ ID NO:533, SEQ ID NO:534, SEQ ID NO:535, SEQ ID NO:536, SEQ ID

3 0 NO:537, SEQ ID NO:538, SEQ ID NO:539, SEQ ID NO:540, SEQ ID NO:541,

SEQ ID NO:542, SEQ ID NO:543, SEQ ID NO:544, SEQ ID NO:545, SEQ ID
NO:546, SEQ ID NO:547, SEQ ID NO:548, SEQ ID NO:549, SEQ ID NO:550,
SEQ ID NO:551, SEQ ID NO:552, SEQ ID NO:553, SEQ ID NO:554 > SEQ ID
NO:555, SEQ ID NO:556, SEQ ID NO:557, SEQ ID NO:558, SEQ ID NO:559,

WO 98/45437

PCT/US98/06956

SEQ ID NO:560, SEQ ID NO:561, SEQ ID
NO:564, SEQ ID NO:565, SEQ ID NO:566,
SEQ ID NO-.569, SEQ ID NO:570, SEQ ID
NO:573, SEQ ID NO:574, SEQ ID NO:575,
5 SEQ ID NO:578, SEQ ID NO:579, SEQ ID

NO:582, SEQ ID NO:S83, SEQ ID NO:584,
SEQ ID NO:587, SEQ ID NO:588, SEQ ID
NO:591, SEQ ID NO:592, SEQ ID NO:593,
SEQ ID NO:596, SEQ ID NO:597, SEQ ID

10 NO:600, SEQ ID NO:601, SEQ ID NO:602,

SEQ ID NO:605, SEQ ID NO:606, SEQ ID
NO:609, SEQ ID NO:610, SEQ ID N0:61 1,
SEQ ID NO:614, SEQ ID NO:615, SEQ ID
NO:618, SEQ ID NO:6l9, SEQ ID NO:620,

15 SEQ ID NO:623, SEQ ID NO:624, SEQ ID

NO:627, SEQ ID NO:628, SEQ ID NO:629,
SEQ ID NO:632, SEQ ID NO:633, SEQ ID
NO:636, SEQ ID NO:637, SEQ ID NO:638,
SEQ ID NO:641, SEQ ID NO:642, SEQ ID

20 NO:645, SEQ ID NO:646, SEQ ID NO:647,

SEQ ID NO:650, SEQ ID NO:651, SEQ ID
NO:654, SEQ ID NO:655, SEQ ID NO:656,
SEQ ID NO:659, SEQ ID NO:660, SEQ ID
NO:663, SEQ ID NO:664, SEQ ID NO:665,

2 5 SEQ ID NO:668, SEQ ID NO:669, SEQ ID

NO:672, SEQ ID NO:673, SEQ ID NO:674,
SEQ ID NO:677, SEQ ID NO:678 t SEQ ID
NO:681, SEQ ID NO:682, SEQ ID NO:683,
SEQ ID NO:686, SEQ ID NO:687, SEQ ID

3 0 NO:690, SEQ ID NO:691, SEQ ID NO:692,

SEQ ID NO:695, SEQ ID NO:696, SEQ ID
NO:699, SEQ ID NO:700, SEQ ID NO:701,
SEQ ID NO:704, SEQ ID NO:705, SEQ ID
NO:708, SEQ ID NO:709, SEQ ID NO:710,

NO:562, SEQ ID NO:563, SEQ ID
SEQ ID NO:567, SEQ ID NO:568,
NO:571, SEQ ID NO:572, SEQ ID
SEQ ID NO:576, SEQ ID NO:577,
NO:580, SEQ ID NO:581, SEQ ID
SEQ ID NO:585, SEQ ID NO:586,
NO:589 7 SEQ ID NO:590, SEQ ID
SEQ ID NO:594, SEQ ID NO:595,
NO:598, SEQ ID NO:599, SEQ ID
SEQ ID NO:603, SEQ ID NO:604,
NO;607, SEQ ID NO:608, SEQ ID
SEQ ID NO:6I2, SEQ ID NO:613,
NO:616, SEQ ID NO:617, SEQ ID
SEQ ID NO:621, SEQ ID NO:622,
NO:625, SEQ ID NO:626, SEQ ID
SEQ ID NO:630, SEQ ID NO:631,
NO:634, SEQ ID NO:635, SEQ ID
SEQ ID NO:639, SEQ ID NO:640,
NO:643, SEQ ID NO:644, SEQ ID
SEQ ID NO:648, SEQ ID NO:649,
NO:652, SEQ ID NO:653, SEQ ID
SEQ ID NO:657, SEQ ID NO:658,
NO:661, SEQ ID NO:662, SEQ ID
SEQ ID NO:666, SEQ ID NO:667,
NO:670, SEQ ID NO:671, SEQ ID
SEQ ID NO:675, SEQ ID NO:676,
NO:679, SEQ ID NO:680, SEQ ID
SEQ ID NO:684, SEQ ID NO:685,
NO:688, SEQ ID NO:689, SEQ ID
SEQ ID NO:693, SEQ ID NO:694,
NO:697, SEQ ID NO:698, SEQ ID
SEQ ID NO:702, SEQ ID NO:703,
NO:706, SEQ ID NO:707, SEQ ID
SEQ ID NO:711, SEQ ID NO:712,

37

WO 98/45437

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SEQ ID NO:713, SEQ ID NO:714, SEQ ID NO:715, SEQ ID N0:716, SEQ ID
NO:717, SEQ ID NO:718, SEQ ID NO:719, SEQ ID NO:720, SEQ ID NO:721,
SEQ ID NO:722, SEQ ID NO;723, SEQ ID NO:724, SEQ ID NO:725, SEQ ID
NO:726, SEQ ID NO:727, SEQ ID NO:728, SEQ ID NO:729, SEQ ID NO:730,
5 SEQ ID NO:731, SEQ ID NO:732, SEQ ID NO:733. SEQ ID NO:734, SEQ ID

NO:735, SEQ ID NO:736, SEQ ID NO:737, SEQ ID NO:738, SEQ ID NO:739,
SEQ ID NO:740, SEQ ID NO:741, SEQ ID NO:742, SEQ ID NO:743, SEQ ID
NO:744, SEQ ID NO:745, SEQ ID NO:746, SEQ ID NO: 747, SEQ ID NO:748,
SEQ ID NO:749, SEQ ID NO:750, SEQ ID NO:751, SEQ ID NO:752, SEQ ID

10 NO:753, SEQ ID NO:754, SEQ ID NO:755, SEQ ID NO:756, SEQ ID NO:757,

SEQ ID NO:758, SEQ ID NO:759, SEQ ID NO:760, SEQ ID NO:761, SEQ ID
NO:762, SEQ ID NO:763, SEQ ID NO:764, SEQ ID NO:765, SEQ ID NO:766,
SEQ ID NO:767, SEQ ID NO:768, SEQ ID NO:769, SEQ ID NO;770, SEQ ID
NO:771, SEQ ID NO:772, SEQ ID NO:773 t SEQ ID NO:774, SEQ ID NO:775,

15 SEQ ID NO:776, SEQ ID NO:777, SEQ ID NO:778, SEQ ID NO:779, SEQ ID

NO:780, SEQ ID NQ:781, SEQ ID NO:782, SEQ ID NO:783, SEQ ID NO:784,
SEQ ID NO:785, SEQ ID NO:786, SEQ ID NO:787, SEQ ID NO:788, SEQ ID
NO:789, SEQ ID NO:790 > SEQ ID NO:791, SEQ ID NO:792, SEQ ID NO:793,
SEQ ID NO:794, SEQ ID NO:795, SEQ ID NO:796, SEQ ID NO:797, SEQ ID

20 NO:798, SEQ ID NO:799, SEQ ID NO:800, SEQ ID NO:801, SEQ ID NO:802,

SEQ ID NO:803, SEQ ID NO:804, SEQ ID NO:805, SEQ ID NO:806, SEQ ID
NO:807, SEQ ID NO:808, SEQ ID NO:809, SEQ ID NO:8iO, SEQ ID NO:81 1,
SEQ ID NO:812, SEQ ID NO:8I3, SEQ ID NO:814 t SEQ ID NO:815, SEQ ID
NO:816, SEQ ID NO:817, SEQ ID NO:818, SEQ ID NO:819, SEQ ID NO:820,

25 SEQ ID NO-.821, SEQ ID NO:822, SEQ ID NO:823, SEQ ID NO:824, SEQ ID

NO:825, SEQ ID NO:826, SEQ ID NO:827, SEQ ID NO:828, SEQ ID NO:829,
SEQ.ID NO:830, SEQ ID NO:831, SEQ ID NO:832, SEQ ID NO:833, SEQ ID
NO:834, SEQ ID NO:835, SEQ ID NO:836, SEQ ID NO:837, SEQ ID NO:838,
SEQ ID NO:839, SEQ ID NO:840, SEQ ID NO:841, SEQ ID NO:842, SEQ ID

3 0 NO:843, SEQ ID NO:844, SEQ ID NO:845, SEQ ID NO:846, SEQ ID NO:847,

SEQ ID NO:848, SEQ ID NO:849, SEQ ID NO:850, SEQ ID NO:851, SEQ ID
NO:852, SEQ ID NO:853, SEQ ID NO:854, SEQ ID NO:855, SEQ ID NO:856,
SEQ ID NO:857, SEQ ID NO:858, SEQ ID NO:859, SEQ ID NO:860, SEQ ID
NO:861, SEQ ID NO:862, SEQ ID NO:863, SEQ ID NO:864, SEQ ID NO:865,

38

WO 98/45437 PCTYUS98/06956

SEQ ID NO:866, SEQ ID NO:867, SEQ ID NO:868, SEQ ID NO:869, SEQ ID
NO:870, SEQ ID NO:871, SEQ ID NO:872, SEQ ID NO:873, SEQ ID NO:874,
SEQ ID NO:875, SEQ ID NO:876, SEQ ID NO:877, SEQ ID NO:878, SEQ ID
NO:879, SEQ ID NO:880, SEQ ID NO:88I, SEQ ID NO:882, SEQ ID NO:883,
5 SEQ ID NO:884, SEQ ID NO:885, SEQ ID NO:886, SEQ ID NO:887, SEQ ID

NO:888, SEQ ID NO:889, SEQ ID NO:890, SEQ ID NO:891, SEQ ID NO:892,
SEQ ID NO:893, SEQ ID NO:894, SEQ ID NO:895, SEQ ID NO:896, SEQ ID
NO:897, SEQ ID N0.898, SEQ ID NO:899, SEQ ID NO:900, SEQ ID NO:901,
SEQ ID NO:902, SEQ ID NO:903, SEQ ID NO:904, SEQ ID NO:905, SEQ ID

10 NO:906, SEQ ID NO:907, SEQ ID NO:908, SEQ ID NO:909, SEQ ID NO:910,

SEQ ID N0:911, SEQ ID NO:9I2, SEQ ID NO:913, SEQ ID NO:9l4, SEQ ID
NO:9l5, SEQ ID NO:916, SEQ ID NO:9l7, SEQ ID NO:9l8, SEQ ID NO:919,
SEQ ID NO:920, SEQ ID NO:92l, SEQ ID NO:922, SEQ ID NO:923, SEQ ID
NO:924, SEQ ID NO:925, SEQ ID NO:926, SEQ ID NO:927, SEQ ID NO:928,

15 SEQ ID NO:929, SEQ ID NO:930, SEQ ID NO:931, SEQ ID NO:932, SEQ ID

NO:933, SEQ ID NO:934, SEQ ID NO:935, SEQ ID NO:936, SEQ ID NO:937,
SEQ ID NO:938, SEQ ID NO:939, SEQ ID NO:940, SEQ ID NO:941, SEQ ID
NO:942, SEQ ID NO:943, SEQ ID NO:944, SEQ ID NO:945, SEQ ID NO:946,
SEQ ID NO:947, SEQ ID NO:948, SEQ ID NO:949, SEQ ID NO:950, SEQ ID

2 0 NO: 951, SEQ ID NO:952, SEQ ID NO:953, SEQ ID NO:954, SEQ ID NO:955,

SEQ ID NO:956, SEQ ID NO:957, SEQ ID NO:958, SEQ ID NO:959, SEQ ID
NO:960, SEQ ID NO:961, SEQ ID NO:962, SEQ ID NO:963, SEQ ID NO:964,
SEQ ID NO:965, SEQ ID NO:966, SEQ ID NO:967, SEQ ID NO:968, SEQ ID
NO:969, SEQ ID NO:970, SEQ ID NO;971, SEQ ID NO:972, SEQ ID NO:973,
25 SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:976, SEQ ID NO:977, SEQ ID

NO:978, SEQ ID NO:979 t SEQ ID NO:980, SEQ ID NO:981, SEQ ID NO:982,
SEQ ID NO:983, SEQ ID NO:984, SEQ ID NO:985, SEQ ID NO:986, SEQ ID
NO:987, SEQ ID NO:988, SEQ ID NO:989, SEQ ID NO:990, SEQ ID NO:991 T
SEQ ID NO:992, SEQ ID NO:993, SEQ ID NO:994, SEQ ID NO:995, SEQ ID

3 0 NO:996, SEQ ID NO:997, SEQ ID NO:998, SEQ ID NO:999, SEQ ID NO: 1000,

SEQ ID NO:1001, SEQ ID NO:1002, SEQ ID NO:1003, SEQ ID NO:1004, SEQ
ID NO: 1005, SEQ ID NO: 1006, SEQ ID NO: 1007, SEQ ID NO: 1008, SEQ ID
NO:1009, SEQ ID NO:1010, SEQ ID NO:1011, SEQ ID NO:1012, SEQ ID
NO:1013, SEQ ID NO:1014, SEQ ID NO:1015, SEQ ID NO:1016, SEQ ID

39

WO 98/45437

PCT/US98/06956

NO:1017.

SEQ

ID

NO: 1018,

NO: 1021,

SEQ

ID

NO: 1022,

NO: 1025,

SEQ

ID

NO: 1026,

NO: 1029.

SEQ

ID

NO: 1030,

5

NO: 1033,

SEQ

ID

NO: 1034,

NO:1037,

SEQ

ID

NO: 1038,

NO:1041,

SEQ

ID

NO: 1042,

NO: 1045,

SEQ

ID

NO: 1046,

NO: 1049,

SEQ

ID

NO: 1050,

10

NO: 1053,

ZEQ

ID

NO: 1054,

NO: 1057,

SEQ

ID

NO:1058,

NO:1061,

SEQ

ID

NO: 1062,

NO: 1065,

SEQ

ID

NO: 1066,

NO: 1069,

SEQ

ID

NO: 1070,

15

NO: 1073,

SEQ

ID

NO: 1074,

NO: 1077,

SEQ

ID

NO: 1078,

NO: 1081,

SEQ

ID

NO: 1082,

NO: 1085,

SEQ

ID

NO: 1086,

NO: 1089,

SEQ

ID

NO: 1090,

20

NO: 1093,

SEQ

ID

NO: 1094,

NO: 1097,

SEQ

ID

NO: 1098,

NO: 1101,

SEQ

ID

NO: 1102,

NO: 1105,

SEQ

ID

NO: 1106,

NO: 1109,

SEQ

ID

NO: 11 10,

25

NO: 11 13,

SEQ

ID

NO: 11 14,

NO: 11 17,

SEQ

ID

NO: 11 18,

NO: 1121,

SEQ

ID

NO: 1122,

NO: 1125,

SEQ

ID

NO: 1126,

NO: 1129,

SEQ

ID

NO: 1130,

30

NO: 1133,

SEQ

ID

NO: 1134,

NO: 1137,

SEQ

ID

NO: 1138,

NO:1141,

SEQ

ID

NO: 1142,

NO: 1145,

SEQ

ID

NO: 1146,

NO: 1149,

SEQ

ID

NO: 1150,

SEQ ID NO: 1019, SEQ ID NO: 1020, SEQ ID
SEQ ID NO: 1023, SEQ ID NO: 1024, SEQ ID
SEQ ID NO: 1027, SEQ ID NO: 1028, SEQ ID
SEQ ID NO: 1031, SEQ ID NO: 1032, SEQ ID
SEQ ID NO: 1035, SEQ ID NO: 1036, SEQ ID
SEQ ID NO: 1039, SEQ ID NO: 1040, SEQ ID
SEQ ID NO: 1043, SEQ ID NO: 1044, SEQ ID
SEQ ID NO: 1047, SEQ ID NO: 1048, SEQ ID
SEQ ID NO: 1051, SEQ ID NO: 1052, SEQ ID
SEQ ID NO: 1055, SEQ ID NO: 1056, SEQ ID
SEQ ID NO: 1059, SEQ ID NO: 1060, SEQ ID
SEQ ID NO: 1063, SEQ ID NO: 1064, SEQ ID
SEQ ID NO: 1067, SEQ ID NO: 1068, SEQ ID
SEQ ID NO: 1071, SEQ ID NO: 1072, SEQ ID
SEQ ID NO:1075, SEQ ID NO:1076, SEQ ID
SEQ ID NO: 1079, SEQ ID NO: 1080, SEQ ID
SEQ ID NO: 1083, SEQ ID NO: 1084, SEQ ID
SEQ ID NO: 1087, SEQ ID NO: 1088, SEQ ID
SEQ ID NO: 1091, SEQ ID NO: 1092, SEQ ID
SEQ ID NO: 1095, SEQ ID NO: 1096, SEQ ID
SEQ ID NO: 1099, SEQ ID NO: 1100, SEQ ID
SEQ ID NO: 1103, SEQ ID NO: 1104, SEQ ID
SEQ ID NO: 1107, SEQ ID NO: 1108, SEQ ID
SEQ ID NO:llll, SEQ ID NO: 11 12, SEQ ID
SEQ ID NO: 11 15, SEQ ID NO:1116, SEQ ID
SEQ ID NO: 11 19, SEQ ID NO: 1 120, SEQ ID
SEQ ID NO: 1123, SEQ ID NO: 1124, SEQ ID
SEQ ID NO: 1127, SEQ ID NO: 1128, SEQ ID
SEQ ID NO:1131, SEQ ID NO:1132, SEQ ID
SEQ ID NO: 1135, SEQ ID NO: 1136, SEQ ID
SEQ ID NO: 1139, SEQ ID NO: 1140, SEQ ID
SEQ ID NO: 1143, SEQ ID NO: 1144, SEQ ID
SEQ ID NO: 1147, SEQ ID NO: 1148, SEQ ID
SEQ ID NO:1151, SEQ ID NO: 1152, SEQ ID

40

WO 98/45437

PCT/US98/06956

10

15

20

25

30

NO:li53,
NO: 1157,
NO:1161,
NO: 1165,
NO: 1169,
NO:I173,
NO: 1177,
NO:1181,
NO:1185,
NO: 1189,
NO: 1193,
NO: 1197,
NO: 1201,
NO: 1205,
NO: 1209,
NO: 1213,
NO: 1217,
NO: 1221,
NO: 1225,
NO: 1229,
NO: 1233,
NO: 1237,
NO: 1241,
NO: 1245,
NO: 1249,
NO: 1253,
NO: 1257,
NO: 1261,
NO: 1265,
NO: 1269,
NO: 1273,
NO: 1277,
NO: 1281,
NO: 1285,

SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID

NO: 1154,
NO: 1 158,
NO: 1162,
NO: 1166,
NO: 1170,
NO: 1 174,
N0:1I78,
NO: 1182,
NO: 1186,
NO: 1190,
NO: 1194,
NO: 1 198,
NO: 1202,
NO: 1206,
NO: 1210,
NO: 1214,
NO:1218,
NO: 1222,
NO: 1226,
NO: 1230,
NO: 1234,
NO:1238,
NO: 1242,
NO: 1246,
NO: 1250,
NO: 1254,
NO: 1258,
NO: 1262,
NO: 1266,
NO: 1270,
NO: 1274,
NO: 1278,
NO: 1282,
NO: 1286,

SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID

NO
NO
NO
NO:
NO:
NO:
NO
NO
NO:
NO:
NO
NO
NO
NO:
NO:
NO:
NO
NO:
NO:
NO:
NO:
NO
NO
NO:
NO:
NO:
NO:
NO:
NO:
NO
NO
NO
NO
NO

1155, SEQ
1159, SEQ
1163, SEQ
1167, SEQ
1171, SEQ
1175, SEQ
1179, SEQ
1183, SEQ
1187, SEQ
1191, SEQ
1195, SEQ
1199, SEQ
1203, SEQ
1207, SEQ
1211, SEQ
1215, SEQ
1219, SEQ
1223, SEQ
1227, SEQ
1231, SEQ
1235, SEQ
1239, SEQ
1243, SEQ
1247, SEQ
1251, SEQ
1255, SEQ
1259, SEQ
1263, SEQ
1267, SEQ
1271, SEQ
1275, SEQ
1279, SEQ
1283, SEQ
1287, SEQ

ID NO: 1156,
ID NO: 1160,
ID NO: 1164,
ID NO: 1168,
ID NO: 1172,
ID NO: 1176,
ID NO: 1180,
ID NO:1184,
ID NO:1188,
ID NO: 1192,
ID NO: 1196,
ID NO: 1200,
ID NO: 1204,
ID NO: 1208,
ID NO:1212,
ID NO: 1216,
ID NO: 1220,
ID NO: 1224,
ID NO: 1228,
ID NO: 1232,
ID NO: 1236,
ID NO: 1240,
ID NO: 1244,
ID NO: 1248,
ID NO: 1252,
ID NO: 1256,
ID NO: 1260,
ID NO: 1264,
ID NO: 1268,
ID NO: 1272,
ID NO: 1276,
ID NO: 1280,
ID NO: 1284,
ID NO:1288,

SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID

41

WO 98/45437

NO; 1289,

SEQ

NO:1293,

SEQ

NO: 1297,

SEQ

NO:1301,

SEQ

5

NO; 1305,

SEQ

NO: 1309,

SEQ

NO:1313,

SEQ

NO:1317,

SEQ

NO-1321

SEQ

10

NO- 1325

SEQ

NO: 1329,

SEQ

NO: 1333,

SEQ

SEQ

NO: 1341,

SEQ

15

NO- 1345

SFO

NO: 1349,

SEQ

NO' 1353

SEQ

NO: 1357,

SEQ

NO* 1361

SEQ

20

NO- 1365

SEQ

NO: 1369,

SEQ

NO: 1373,

SEQ

NO: 1377,

SEQ

NO:1381,

SEQ

25

NO: 1385,

SEQ

NO: 1389,

SEQ

^FO

NO: 1397,

SEQ

NO: 1401,

SEQ

30

NO: 1405,

SEQ

NO: 1409,

SEQ

NO:1413,

SEQ

NO: 1417,

SEQ

NO: 1421,

SEQ

ID NO: 1290, SEQ ID NO:
ID NO: 1294, SEQ ID NO:
ID NO: 1298, SEQ ID NO:
ID NO: 1302, SEQ ID NO:
ID NO: 1306, SEQ ID NO:
ID NO: 13 10, SEQ ID NO:
ID NO: 1314, SEQ ID NO:
ID NO: 13 18, SEQ ID NO:
ID NO: 1322, SEQ ID NO:
ID NO: 1326, SEQ ID NO:
ID NO: 1330, SEQ ID NO:
ID NO: 1334, SEQ ID NO:
ID NO: 1338, SEQ ID NO:
ID NO: 1342, SEQ ID NO:
ID NO: 1346, SEQ ID NO:
ID NO: 1350, SEQ ID NO:
ID NO: 1354, SEQ ID NO:
ID NO: 1358, SEQ ID NO:
ID NO: 1362, SEQ ID NO:
ID NO: 1366, SEQ ID NO:
ID NO: 1370, SEQ ID NO:
ID NO: 1374, SEQ ID NO:
ID NO: 1378, SEQ ID NO:
ID NO: 1382, SEQ ID NO:
ID NO: 1386, SEQ ID NO:
ID NO: 1390, SEQ ID NO:
ID NO: 1394, SEQ ID NO:
ID NO: 1398, SEQ ID NO:
ID NO: 1402, SEQ ID NO:
ID NO: 1406, SEQ ID NO:
ID NO: 1410, SEQ ID NO:
ID NO: 14 14, SEQ ID NO:
ID NO: 1418, SEQ ID NO:
ID NO: 1422, SEQ ID NO:

PCT/US98/06956

1291,

SEQ

ID

NO: 1292,

SEQ ID

1295,

SEQ

ID

NO: 1296,

SEQ ID

1299,

SEQ

ID

NO: 1300,

SEQ ID

1303,

SEQ

ID

NO: 1304,

SEQ ID

1307,

SEQ

ID

NO: 1308,

SEQ ID

131 1,

SEQ

ID

NO: 1312,

SEQ ID

1315,

SEQ

ID

NO: 1316,

SEQ ID

1319,

SEQ

ID

NO- 1 390

9FO TF>

1323,

SEQ

ID

NO- 1394

opn in

1 177

SFO

in

NO- 1 178

cpn in

1 11 1

<?fo

in

XXJ

NO- 1 11?

1 IIS

\Y\
iU

MO- 1 H£

pen TP*

1 11Q

1 JJ7,

9FO

in

NO* 1 140

IN \J. X •>*H/,

epn TO
OlZfVf XXJ

1341

C.FO

in

XXJ

NO- 1144

cpn in

1347

NO- 1 14R

cpn in

11S1

in

XXJ

NO* 1 1S?

cpn m

1 155

XJ J>J ,

ID

XXJ

NO* 115ft

cpn TD

1 15Q

9FO

ID

NO- 1160

SEQ ID

1363,

SEQ

ID

NO- 1364

SEQ ID

1367,

SEQ

ID

NO- 1368

SEQ ID

1371,

SEQ

ID

NO- 1372

SEQ ID

1375,

SEQ

ID

NO- 1376

SEQ ID

1379,

SEQ

ID

NO- 1380

SEQ ID

1383,

SEQ

ID

NO' 1384

SEQ ID

1387,

SEQ

ID

NO: 1388,

SEQ ID

1391,

SEQ

ID

NO: 1392,

SEQ ID

id

NO- 1 ^QA
IN^J. 1 J7D,

cpo rr>

OX~Z\£ XXJ

1399,

SEQ

ID

NO: 1400,

SEQ ID

1403,

SEQ

ID

NO: 1404,

SEQ ID

1407,

SEQ

ID

NO: 1408,

SEQ ID

1411,

SEQ

ID

NO: 1412,

SEQ ID

1415,

SEQ

ID

NO: 1416,

SEQ ID

1419,

SEQ

ID

NO: 1420,

SEQ ID

;1423,

SEQ

ID

NO: 1424,

SEQ ID

42

I. Ill III

hiiiiiiijiUiiiiiiiijiiiliilililili

WO 98/45437

PCT/US98/06956

10

15

20

NO: 1425,

Ouy

ID

NO- 1426

^FO

ID

NO: 1427,

SEQ

ID

NO: 1428,

sfo in

NO: 1429,

ID

NO- 14^0

SFD

ID

NO: 1431,

SEQ

ID

NO: 1432,

^fo in

NO: 1433,

SEQ

ID

NO: 1434,

SEQ

ID

NO:1435,

SEQ

ID

NO* 1436

SEQ ID

NO: 1437,

^FO

in

1 i-J

NO: 1438,

c FO

ID

NO: 1439,

SEQ

ID

NO: 1440

cpo in

NO: 1441,

^FO

ID

NO: 1442,

SFO

ID

NO: 1443,

SEQ

ID

NO: 1444

cfo in

NO: 1445

c FO

ILJ

NO - 1446

c FO

OLy

ID

NO: 1447,

SEQ

ID

NO- 1448

cpn rn

NO- 144.0

in

NO- 14S0

c FO

in

NO: 145 1

SFO

in

1 LJ

NO* 1 4S9

cpn in

MO- 14*^

NO- 14S4

iJDy

in

ILJ

NO- 14*5*5

SFO

in

ILJ

NO- 1456

CPO TPl
&tl\l ID

MO* 14^7

CCA

td

XT A. 1 ,4SR

CpA

irv

MA- 14^Q

cpn

ILJ

MO- 1 46H

CPO ID

14D 1 ,

OCA

XI a. 1 AfSy

CPA

TP*

MO • 1 Aft'X
lS\J. 140.?,

ceo

ID
ID

KT A. 1 Afs.A
JNvJ. 1404,

ceo ir*i

OCl^J 1JJ

ri\J. 1403,

CCA

onAJ_

IF*

MA. 1 Afxfx

CPA

MO - 1467

CPA
iEy

in

ID

MO- 1 AfkSi

CCO ID
OEy ID

INU. i4t>y,

crA

XI A - 1 AHC\
XNvJ. 14 /y,

CCA

ID

MA, 1/1*7 1
INVJ. 14 / 1 ,

CPO

ID

XT O- 1/177
1NU. 14 /Z,

CPO ID
oEy ID

MA- 1 ^70

CCA

LD

XT A • 1 AHA
INvJ. 14 /4,

ceo

iu

MO- 147*\

CPO

oEy

id

ID

MO- 1 AHfs.
r*\J, 14 /O,

CPO TPi
OEV^J ID

INVJ. 14/ /,

pc A

ID

MA - 1/178
INV-J. 14 /O,

CPA

IFk
ID

MO - 147Q

8FO

in

MA. I /IOA

CPO ID
oDy ID

INLJ. 14o I ,

XT A- 1 >187

CPA

id

MO- 148^

m

ID

MO- 1484

CPO TD

MA« UQ^

CCA

in
ID

MA- 1 AQ.A

CPA

If

MO- 1487
INW. k^O / ,

CPO
oEy

id

MO- 1 488

CPO ID

NO: 1489,

SEQ

ID

NO: 1490,

SEQ

ID

NO: 1491,

SEQ

ID

NO: 1492,

PCT A ITA

SbQ ID

NO: 1493,

SEQ

ID

NO: 1494,

SEQ

ID

NO: 1495,

SEQ

ID

NO: 1496,

SEQ ID

NO: 1497,

SEQ

ID

NO: 1498,

SEQ

ID

NO: 1499,

SEQ

ID

NO: 1500,

SEQ ID

NO: 1501,

SEQ

ID

NO: 1502,

SEQ

ID

NO: 1503,

SEQ

ID

NO: 1504,

SEQ ID

NO: 1505,

SEQ

ID

NO: 1506,

SEQ

ID

NO: 1507,

SEQ

ID

NO: 1508,

SEQ ID

NO: 1509,

SEQ

ID

NO: 1510,

SEQ

ID

NO: 1511,

SEQ

ID

NO: 1512,

SEQ ID

NO:1513,

SEQ

ID

NO: 15 14,

SEQ

ID

NO: 15 15,

SEQ

ID

NO: 1516,

SEQ ID

NO:1517,

SEQ ID NO: 15 18, and SEQ ID NO: 1519;

25

or to a complement of said sequence.

The invention also provides for proteins encoded by the above-described
polynucleotides.

DETAILED DESCRIPTION
3 0 The nucleotide sequences of the sESTs of the present invention are reported in the

Sequence Listing below. Table 2 lists the "Clone ID Nos." assigned by applicants to each
SEQ ID NO: in the Sequence Listing.

43

WO 98/45437

PCT/US98/06956

Table 2.

Each pair of entries in this table consists of the SEQ ID NO (e.g., 1, 2, etc.)
followed by the Clone ID No. for such sequence (e.g., B1K B18, etc.).

1

BK8

32

62

DY307

93

DY61 1

5

2

BV216

DW1001

63

DY643

94

EC259

3

BV274

33

DW831

64

DY656

95

DY711

4

BV48

34

DW859

65

DY675

96

EC248

5

DN35I

35

DW875

66

DY988

97

EC32

6

DN381

36

DW888

67

DY992

98

DO703

10

7

DN405

37

DW901

68

DY225

99

D0713

8

DU651

38

DW902

69

DY236

100

DR294

9

DU660

39

DW904

70

DY242

101

DY1

10

DU675

40

DW905

71

DY254

102

DY10

11

DU684

41

DW906

72

DY914

103

DY106

15

12

DD364

42

DW929

73

DY946

104

DY117

13

DD379

43

DW981

74

DY955

105

DY148

14

DD389

44

DX191

75

DY959

106

DY167

15

DD401

45

DX219

76

DY961

107

DY17

16

DD413

46

DX245

77

DY981

108

DY174

20

17

DD426

47

DX256

78

DY357

109

DY175

18

DD428

48

DX267

79

DY358

110

DY178

19

DN293

49

DX66

80

DY381

111

DY23

20

DD454

50

DX81

81

DY413

112

DY27

21

DD472

51

DY780

82

DY414

113

DY41

25

22

DD475

52

DY803

83

DY415

114

DY42

23

DT306

53

DY809

84

DY431

115

DY8

24

DW282

54

.DY814

85

DY433

116

DY93

25

DW300

55

DY261

86

DY436

117

EB107

26

DW303

56

DY264

87

DY543

118

EB113

30

27

DW323

57

DY266

88

DY565

119

EB163

28

DT258

58

DY271

89

DY585

120

EB25

29

DW246

59

DY287

90

DY331

121

EB77

30

DW324

60

DY297

91

DY586

122

EC 172

31

DW333

61

DY306

92

DY696

123

EC302

44

WO 98/45437

PCT/US98/06956

124

EC3 17

158

EJ90

192

EJ224

226

FP778

125

EC328

159

EM270

193

EJ240

227

FP7R

126

EC341

160

EM278

194

EJ254

228

LjKJ 1U7

127

EC349

161

EN 186

195

EJ258

229

FO190

5

128

ED 105

1 69

I Oi

EN215

196

EJ265

230

FOl 66

129

ED21

163

EN2 17

197

EJ280

23 1

FOl f?7

FD?7

1 64

1 OH

FN974

198

FI9RS

JZZiJZrO J

919

Z J z

FOl 88

1 7 1

CLJjkJ

1 6S
i oo

FN97Q
jc.iNZ.-j y

1 7 7

F 1707

911

Z j J

FOl OO

I jZ

FH47

1 66

FN? ^6

?on

FRR

974

FOl 04

± V

CJL/04

1 67
i D /

FN960
njNzv>f

901

ZV» J

no97

JLJ WZO J

97^

ZOO

Jbv^zu/

1 74

cc i 77
C/E* 1 / /

1 68
1 DO

FN? 64

L/UiJ 0

976
ZOO

FO908

1 7^

FN966

907
ZVJ

noo67

977

ZO /

r:r*\7 1 A

1 76
i OO

1 70

904

noi i o

978
ZO o

F09 1 ^

1 J /

1 71
1 / i

FXI974
cMN Z / 4

90<;

ZU J

FT794
EJOZ4

97Q
ZJV

1 c;

JL D

I JO

UIVJ77

1 77

906
ZVJO

F1\1A70

940
Z4U

F09 1 0

1 TQ

nni i 98

Uw I 1 Zo

1 77
I /o

F"W7 1 n

907
zu /

FN/177

941
Z4 1

F0990

140

nn 1 1

L/W 1 1 JU

1 74

FN749

90X
zuo

FNS7Q

CrN JO 7

949

ZHZ

FO?91

1 1*\

FN767

900

FP4S1

C»r *rO 1

947

FO??6

1HZ

H749

1 76
1 /o

FN497

910

Z 1 V/

FO10

944

I 40

PP1 16

E/Er I ID

1 77
l / /

FH106

91 1

F014

94 S

EQ230

144
i ****

FFQ7

1 7X
1 /o

FH1 4S

i 212

E048

246

EQ231

14S

1 7Q

EH 166

213

E058

247

EQ233

146

DJ402

180

EH 167

214

£060

248

EQ237

147

DN551

181

EH178

215

E062

249

EQ261

25

148

DN559

182

EH 180

216

EO68

250

EQ272

149

DN603

183

EH 186

217

E089

251

ER104

1 50

DN629

184

EH 188

218

EO90

252

bKJUo

I5l

DN631

185

EHt 89

219

E092

253

ER128

152

DOll

186

EH 190

220

E097

254

ERI34

30

153

DOH8

187

EH203

221

EP108

255

ER174

154

D015

188

EH206

222

EP165

256

ER201

155

D0157

189

EH95

223

EP219

257

ER77

156

D019

190

EJ148

224

EP234

258

ER80

157

EJ53

191

EJ179

225

EP277

259

ER97

45

WO 98/45437

PCT/US98/06956

260

ESI36

294

ER399

261

ES306

295

ER408

262

ES35

296

ER4I8

263

ES37

297

ER430

264

ES206

298

ER471

265

ET13

299

ER476

266

ET22

300

ER493

267

ET39

301

ER496

268

ET84

302

ER498

269

EF121

303

ER524

270

EF129

304

EW13

271

EF45

305

EX25

272

EF48

306

EX53

273

EF5

307

EY165

274

EF88

308

EY29

275

EG 194

309

EZ35

276

EG251

310

EZ4

277

EH12

311

EZ88

278

EH213

312

EZ93

279

EH22

313

FA8

280

EH221

314

EV234

281

EH248

315

EW101

282

EH29

316

EW109

283

EH61

317

EW150

284

EH68

318

EY197

285

EH78

319

EY206

286

EH80

320

EY215

287

ER311

321

EZ209

288

ER329

322

FA139

289

ER343

323

FA171

290

ER366

324

FA252

291

ER369

325

FA28

292

ER381

326

FA316

293

ER395

327

FA95

328

FB264

362

FG208

329

FB38

363

FG265

330

FB71

364

FG274

331

FB78

365

FG278

332

FC12

366

FG281

333

FB349

367

FG291

334

FC136

368

FG294

335

FC170

369

FG340

336

FD152

370

FG363

337

FE141

371

FG372

338

FE5

372

FG380

339

FD131

373

FG401

340

EC425

374

FG99

341

EC428

375

FI203

342

ED204

376

FE311

343

ED205

377

FE315

344

ED210

378

FE322

345

ED223

379

FE329

346

DI301

380

FE341

347

DI303

381

FE366

348

DI310

382

FE375

349

DI39

383

FE412

350

DJ90

384

FE415

351

DM290

385

FE442

352

DM304

386

FE472

353

DN618

387

FE557

354

DN896

388

FE568

355

DN904

389

FE619

356

FG119

390

FE676

357

FG126

391

FE682

358

FG140

392

FF150

359

FG193

393

FF153

360

FG197

394

FF168

361

FG198

395

FF175

46

WO 98/45437 PCT/US98/06956

396

FFI81

430

FH17

464

FN203

4QR

rUZU I

397

FF46

431

FH170

465

FN228

4QQ

398

FF49

432

FH24

466

FN229

son

F07 1 1
ruz 1 i

399

FF97

433

FH3

467

FM251

5

400

FG41

434

FH39

468

FN254

401

FG437

435

FH56

469

FP134

402

FG441

436

FH6

470

FP14

jU4

rOzol

403

FG448

437

FH66

471

rn u_>

rUzo /

404

FG45

438

FM109

47?

*T / At

r r I /z

v>0o

F0275

10

405

FG492

439

FM13

471

r r / 1

cm

FO290

406

FG504

440

FMl S

A1A

FP»7
rro /

dOo

FU292

407

FG565

441

FM1 SO

47S

Fl 1 1 fi

->UV

F03 1 6

408

FG567

442

FMl 70

Alf\

FI 1 £

CIA

j 10

F0324

409

FG57

443

r 1VIZO

All

PI 1 C7

5 1 1

F0327

15

410

FG577

444

FM3

AIR

FI7fH

D 12

rOJ48

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142 1

tt>30

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135 /

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i a in

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HZ 109

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IJ1201

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HZ1 1 1

1392

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1458

IJ 1220

1 360

HZ1 15

HW1044

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IJ 1 237

1 361

HZ71

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1426

IC142

1460

IJ 1240

15

1 1 /TO

1362

HZ76

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IC 1 55

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IJ1247

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1Cj4

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IJ 1 287

1 *1 HA

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HW 1 1 D

1395

HW432

^ /ion
1429

ICo /

1463

i f i

IJ1292

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HW 12o

1396

HW440

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1 A £.A

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u i2yy

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lb 1*10

1403

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1 30/

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HW518

1 /IT)

1432

lb 14 /

1400

T T^Q7

UDy2

1308

H W4V 1

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1 /177

1433

lbl4y

1 A&7

140 /

I ICQ7

1 7 6Q

i joy

ri W4yy

1400

HW598

1 474

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lb toy

1 /AS
1408

T 1670
1J029

1 77ft
13 /U

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1401

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143 J

lZO

140y

1 1678

1 771

H71 1 6

1402

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uv>*tu

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it / 1

n7i

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1 479

IJ686

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HZ20I

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IE10

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IE47

1474

IG35

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HZ262

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HW711

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IE73

1475

IH40

30

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IA106

1408

HW715

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JA37

1476

IH54

1378

IA110

1409

HW730

1443

JA78

1477

IJ288

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1410

HW732

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54

WO 98/45437

PCT/US98/06956

1 A Q 1
1 4o 1

lr j4o

1 C 1 c
1 J I J

1 < 1 A
I D I 0

li>4oo

1 A

1 4oJ

U 1 U4o

1 < 1 7
I J 1 /

jo4

1 A Si A
1 404

1J I UZ>4

1 J lo

1 1 15

b

1 A ec

1J lUoO

Km

\TA A

1 1 44

\ 4oo

t 1*7-7-7
IJ / / /

1 4o /

1 ICQ"?

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! TAA"7

I A OA

IJ928

10

1490

I TO A »1

IJ942

1491

IL1

1492

IL100

1493

IL1 12

1494

IL28

15

1495

IK1 1

1496

IK.14

1497

IK20

1498

IK203

i /ion

iiv2oy

20

IK212

XlflAI

lrs-343

1K./3

1 CAT

I w I 34

1 DU4

lVjl Jo

1 sns

1 JUJ

1U 1 J i

1506

1507

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1508

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1510

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IQ15

1513

IQ45

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IQ55

55

WO 98/45437

PCTYUS98/06956

The "Clone ID No." for a particular clone consists of one or two letters followed by a
number. The letters designate the tissue source from which the sEST was isolated. Table
3 below lists the various sources which were run through applicants' signal sequence trap.
Thus, the tissue source for a particular sEST sequence can be identified in Table 3 by the
5 one and two letter designations used in the relevant "Clone ID No. " . For example, a clone
designated as "BA312" would have been isolated from a human placenta (26 yrs.) library
(i.e., selection "BA") as indicated in Table 3.

As used herein, "polynucleotide" includes single- and double-stranded RNAs,
DNAs and RNA:DNA hybrids.

10 As used heiein a "secreted" protein is one which, when expressed in a suitable host

cell, is transported across or through a membrane, including transport as a result of signal
sequences in its amino acid sequence. "Secreted" proteins include without limitation
proteins secreted wholly (e.g. , soluble proteins) or partially (e.g. , receptors) from the cell
in which they are expressed. "Secreted" proteins also include without limitation proteins

15 which are transported across the membrane of the endoplpasmic reticulum.

Fragments of the proteins of the present invention which are capable of exhibiting
biological activity are also encompassed by the present invention. Fragments of the protein
may be in linear form or they may be cyclized using known methods, for example, as
described in H.U. Saragovi, et aL f Bio/Technology 10, 773-778 (1992) and in R.S.

2 0 McDowell, et al., J. Amer. Chem. Soc. 114, 9245-9253 (1992), both of which are
incorporated herein by reference. Such fragments may be fused to carrier molecules such
as immunoglobulins for many purposes, including increasing the valency of protein binding
sites. For example, fragments of the protein may be fused through "linker" sequences to
the Fc portion of an immunoglobulin. For a bivalent form of the protein, such a fusion

2 5 could be to the Fc portion of an IgG molecule. Other immunoglobulin isotypes may also

be used to generate such fusions. For example, a protein - IgM fusion would generate a
decavalent form of the protein of the invention.

The present invention also provides both full-length and mature forms of the
disclosed proteins. The full-length form of the such proteins is identified in the sequence

3 0 listing by translation of the nucleotide sequence of each disclosed clone. The mature form

of such protein may be obtained by expression of the disclosed full-length polynucleotide
(preferably those deposited with ATCC) in a suitable mammalian cell or other host cell.
The sequence of the mature form of the protein may also be determinable from the amino
acid sequence of the full-length form.

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The present invention also provides genes corresponding to the cDNA sequences
disclosed herein. The corresponding genes can be isolated in accordance with known
methods using the sequence information disclosed herein. Such methods include the
preparation of probes or primers from the disclosed sequence information for identification
5 and/or amplification of genes in appropriate genomic libraries or other sources of genomic
materials.

Where the protein of the present invention is membrane-bound (e.g., is a receptor),
the present invention also provides for soluble forms of such protein. In such forms part
or all of the intracellular and transmembrane domains of the protein are deleted such that
10 the protein is fully secreted from the cell in which it is expressed. The intracellular and
transmembrane domains of proteins of the invention can be identified in accordance with
known techniques for determination of such domains from sequence information.

Species homologs of the disclosed polynucleotides and proteins are also provided
by the present invention. Species homologs may be isolated and identified by making
15 suitable probes or primers from the sequences provided herein and screening a suitable
nucleic acid source from the desired species.

The invention also encompasses allelic variants of the disclosed polynucleotides or
proteins; that is, naturally-occurring alternative forms of the isolated polynucleotide which
also encode proteins which are identical, homologous or related to that encoded by the
2 0 polynucleotides disclosed herein.

The invention also includes polynucleotides with sequences complementary to those
of the polynucleotides disclosed herein.

The present invention also includes polynucleotides capable of hybridizing,
preferably under reduced stringency conditions, more preferably under stringent conditions,
25 most preferably under highly stringent conditions, to polynucleotides described herein.
Examples of stringency conditions are shown in Table 1 below: highly stringent conditions
are those that are at least as stringent as, for example, conditions A-F; stringent conditions
are at least as stringent as, for example, conditions G-L; and reduced stringency conditions
are at least as stringent as, for example, conditions M-R.

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WO 98/45437 PCT/US98/06956

Table 1

Stringenc

y

Condition

Polynucleotide
Hybrid

Hybrid
Length

(bp)*

Hybridization Temperature
and Buffer*

Wash

Temperature
and Buffer'

A

DNA:DNA

> 50

65 °C; lxSSC -or-
42°C; lxSSC, 50%
forrnamide

65°C; 0.3xSSC

B

DNA:DNA

<50

T B *; lxSSC

T B *; lxSSC

C

DNAiRNA

* 50

67°C; lxSSC -or-
45°C; lxSSC, 50%
forrnamide '

67°C; 0.3xSSC

D

DNA:RNA

<50

T D *; lxSSC

T D *; lxSSC

E

RNA:RNA

* 50

70°C; lxSSC -or-
50°C; lxSSC, 50%
forrnamide

70°C; 0.3xSSC

F

RNA:RNA

<50

T F *; lxSSC

T r *; lxSSC

G

DNA:DNA

* 50

65 °C; 4xSSC -or-
42°C- 4xSSC 50%
forrnamide !

65°C; lxSSC

H

DNA:DNA

<50

T H *; 4xSSC

T H *; 4xSSC

I

DNA:RNA

* 50

67°C; 4xSSC -or-
45°C; 4xSSC, 50%
forrnamide

67°C; lxSSC

J

DNA:RNA

<50

Tj*; 4xSSC

T,*; 4xSSC

K

RNA:RNA

* 50

70°C; 4xSSC -or-
50°C; 4xSSC, 50%
forrnamide

67°C; lxSSC

L

RNA:RNA

<50

T L *; 2xSSC

T L *; 2xSSC

M

DNA:DNA

* 50

50°C; 4xSSC -or-
40°C; 6xSSC, 50%
forrnamide

50° C; 2xSSC

N

DNA:DNA

<50

T N *; 6xSSC

T N *; 6xSSC

0

DNA:RNA

* 50

55° C; 4xSSC -or-
42°C; 6xSSC, 50%
forrnamide

55°C; 2xSSC

P

DNArRNA

<50

T P *; 6xSSC

T P *; 6xSSC

Q

RNA:RNA

* 50

60°C; 4xSSC -or-
45°C; 6xSSC, 50%
forrnamide

60°C; 2xSSC

R

RNA:RNA

<50

T R *; 4xSSC

Tr*; 4xSSC

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*: The hybrid length is that anticipated for the hybridized region(s) of the
hybridizing polynucleotides. When hybridizing a polynucleotide to a target polynucleotide
of unknown sequence, the hybrid length is assumed to be that of the hybridizing
polynucleotide. When polynucleotides of known sequence are hybridized, the hybrid length
5 can be determined by aligning the sequences of the polynucleotides and identifying the

region or regions of optimal sequence complementarity.

*: SSPE (IxSSPEis 0.15M NaCl, lGmM NaH 2 P0 4l and 1.25mM EDTA, pH 7.4)
can be substituted for SSC (IxSSC is 0. 15M NaCl and 15mM sodium citrate) in the
hybridization and wash buffers; washes are performed for 15 minutes after hybridization is
10 complete.

*T B - T R : The hybridization temperature for hybrids anticipated to be less than 50
base pairs in length should be 5-10°C less than the melting temperature (TJ of the hybrid,
where T m is determined according to the following equations. For hybrids less than 18 base
pairs in length, T m (°C) = 2(# of A + T bases) + 4(# of G + C bases). For hybrids
15 between 18 and 49 base pairs in length, T m (°C) = 81,5 4- X6.6Q&Z [Na + ]) +

0.41(%G+C) - (600/N), where N is the number of bases in the hybrid, and [Na + J is the
concentration of sodium ions in the hybridization buffer ([Na + ] for IxSSC = 0.165 M).

Additional examples of stringency conditions for polynucleotide hybridization are

2 0 provided in Sambrook, J., E.F. Fritsch, and T. Maniatis, 1989, Molecular Cloning: A

Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY,
chapters 9 and 11, and Current Protocols in Molecular Biology, 1995, F.M. Ausubel et ah,
eds., John Wiley & Sons, Inc. , sections 2. 10 and 6.3-6.4, incorporated herein by reference.
Preferably, such hybridizing polynucleotides have at least 70% sequence identity
25 (more preferably, at least 80% identity; most preferably at least 90% or 95% identity) with
the polynucleotide of the present invention to which they hybridize, where sequence identity
is determined by comparing the sequences of the hybridizing polynucleotides when aligned
so as to maximize overlap and identity while minimizing sequence gaps. The isolated

polynucleotide encoding the protein of the invention may be operably linked to an

3 0 expression control sequence such as the pMT2 or pED expression vectors disclosed in

Kaufman et at., Nucleic Acids Res. 12, 4485-4490(1991), in order to produce the protein
recombinantly . Many suitable expression control sequences are known in the art. General
methods of expressing recombinant proteins are also known and are exemplified in R.
Kaufman, Methods in Enzymology 185, 537-566 (1990). As defined herein "operably
3 5 linked" means that the isolated polynucleotide of the invention and an expression control

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sequence are situated within a vector or cell in such a way that the protein is expressed by
a host cell which has been transformed (transfected) with the ligated
polynucleotide/expression control sequence.

A number of types of cells may act as suitable host cells for expression of the
5 protein. Mammalian host cells include, for example, monkey COS cells, Chinese Hamster
Ovary (CHO) cells, human kidney 293 cells, human epidermal A431 cells, human Colo2Q5
cells, 3T3 cells, CV-1 cells, other transformed primate cell lines, normal diploid cells, cell
strains derived from in vitro culture of primary tissue, primary explants, HeLa cells, mouse
L cells, BHK, HL-60, U937, HaK or Jurkat cells.

10 Alternatively, it may be possible to produce the protein in lower eukaryotes such

as yeast or in prokaryotes such as bacteria. Potentially suitable yeast strains include
Saccharomyces cerevisiae, Schizosaccharomyces pombe, Kluyveromyces strains, Candida,
or any yeast strain capable of expressing heterologous proteins. Potentially suitable
bacterial strains include Escherichia coli, Bacillus subtilis, Salmonella typhimurium, or any

1 5 bacterial strain capable of expressing heterologous proteins. If the protein is made in yeast
or bacteria, it may be necessary to modify the protein produced therein, for example by
phosphorylation or glycosylation of the appropriate sites, in order to obtain the functional
protein. Such covalent attachments may be accomplished using known chemical or
enzymatic methods.

20 The protein may also be produced by operably linking the isolated polynucleotide

of the invention to suitable control sequences in one or more insect expression vectors, and
employing an insect expression system. Materials and methods for baculovirus/insect cell
expression systems are commercially available in kit form from, e.g., Invitrogen, San
Diego, California, U.S.A. (the MaxBac® kit), and such methods are well known in the art,

25 as described in Summers and Smith, Texas Agricultural Experiment Station Bulletin No.
1555 (1987V incorporated herein by reference. As used herein, an insect cell capable of
expressing a polynucleotide of the present invention is "transformed."

The protein of the invention may be prepared by culturing transformed host cells
under culture conditions suitable to express the recombinant protein. The resulting

3 0 expressed protein may then be purified from such culture (i.e. , from culture medium or cell
extracts) using known purification processes, such as gel filtration and ion exchange
chromatography. The purification of the protein may also include an affinity column
containing agents which will bind to the protein; one or more column steps over such
affinity resins as concanavalin A-agarose, heparin-toyopearl® or Cibacrorn blue 3GA

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Sepharose®; one or more steps involving hydrophobic interaction chromatography using
such resins as phenyl ether, butyl ether, or propyl ether; or immunoafftnity
chromatography.

Alternatively, the protein of the invention may also be expressed in a form which
5 will facilitate purification. For example, it may be expressed as a fusion protein, such as
those of maltose binding protein (MBP), glutathione-S-transferase (GST) or thioredoxin
(TRX). Kits for expression and purification of such fusion proteins are commercially
available from New England BioLab (Beverly, MA), Pharmacia (Piscataway, NJ) and
InVitrogen, respectively. The protein can also be tagged with an epitope and subsequently
10 purified by using a specific antibody directed to such epitope. One such epitope ("Flag")
is commercially available from Kodak (New Haven, CT).

Finally, one or more reverse-phase high performance liquid chromatography (RP-
HPLC) steps employing hydrophobic RP-HPLC media, e.g., silica gel having pendant
methyl or other aliphatic groups, can be employed to further purify the protein. Some or
15 all of the foregoing purification steps, in various combinations, can also be employed to
provide a substantially homogeneous isolated recombinant protein. The protein thus
purified is substantially free of other mammalian proteins and is defined in accordance with
the present invention as an "isolated protein/'

The protein of the invention may also be expressed as a product of transgenic
2 0 animals, e.g., as a component of the milk of transgenic cows, goats, pigs, or sheep which
are characterized by somatic or germ cells containing a nucleotide sequence encoding the
protein.

The protein may also be produced by known conventional chemical synthesis.
Methods for constructing the proteins of the present invention by synthetic means are

2 5 known to those skilled in the art. The synthetically-constructedprotein sequences, by virtue

of sharing primary, secondary or tertiary structural and/or conformational characteristics
with proteins may possess biological properties in common therewith, including protein
activity. Thus, they may be employed as biologically active or immunological substitutes
for natural, purified proteins in screening of therapeutic compounds and in immunological

3 0 processes for the development of antibodies.

The proteins provided herein also include proteins characterized by amino acid
sequences similar to those of purified proteins but into which modification are naturally
provided or deliberately engineered. For example, modifications in the peptide or DNA
sequences can be made by those skilled in the art using known techniques. Modifications

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of interest in the protein sequences may include the alteration, substitution, replacement,
insertion or deletion of a selected amino acid residue in the coding sequence. For example,
one or more of the cysteine residues may be deleted or replaced with another amino acid
to alter the conformation of the molecule. Techniques for such alteration, substitution,
5 replacement, insertion or deletion are well known to those skilled in the art (see, e.g., U.S.
Patent No. 4,518,584). Preferably, such alteration, substitution, replacement, insertion or
deletion retains the desired activity of the protein.

Other fragments and derivatives of the sequences of proteins which would be
expected to retain protein activity in whole or in part and may thus be useful for screening
10 or other immunological methodologies may also be easily made by those skilled in the art
given the disclosures herein. Such modifications are believed to be encompassed by the
present invention.

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USES AND BIOLOGICAL ACTIVITY

The polynucleotides and proteins of the present invention are expected to exhibit
one or more of the uses or biological activities (including those associated with assays cited
herein) identified below. Uses or activities described for proteins of the present invention
5 may be provided by administration or use of such proteins or by administration or use of
polynucleotides encoding such proteins (such as, for example, in gene therapies or vectors
suitable for introduction of DNA).

Research Uses and Utilities

1 0 The polynucleotides provided by the present invention can be used by the research

community for various purposes. The primary use of polynucleotides of the invention
which are sESTs is as porbes for the identification and isolation of full-length cDNAs and
genomic DNA molecules which correspond (i.e., is a longer polynucleotide sequence of
which substantially the entire sEST is a fragment in the case of a full-length cDNA, or

15 which encodes the sEST in the case of a genomic DNA molecule) to such sESTs.
Techniques for use of such sequences as probes for larger cDNAs or genomic molecules
are well known in the art.

The polynucleotides can also be used to express recombinant protein for analysis,
characterization or therapeutic use; as markers for tissues in which the corresponding

2 0 protein is preferentially expressed (either constitutively or at a particular stage of tissue

differentiation or development or in disease states); as molecular weight markers on
Southern gels; as chromosome markers or tags (when labeled) to identify chromosomes or
to map related gene positions; to compare with endogenous DNA sequences in patients to
identify potential genetic disorders; as probes to hybridize and thus discover novel, related
25 DNA sequences; as a source of information to derive PCR primers for genetic
fingerprinting; as a probe to "subtract-out" known sequences in the process of discovering
other novel polynucleotides; for selecting and making oligomers for attachment to a "gene
chip" or other support, including for examination of expression patterns; to raise anti-
protein antibodies using DNA immunization techniques; and as an antigen to raise anti-

3 0 DNA antibodies or elicit another immune response. Where the polynucleotide encodes a

protein which binds or potentially binds to another protein (such as, for example, in a
receptor- ligand interaction), the polynucleotide can also be used in interaction trap assays
(such as, for example, that described in Gyuris et al., Cell 75:791-803 (1993)) to identify

63

WO 98/45437

PCT/US98/06956

polynucleotides encoding the other protein with which binding occurs or to identify
inhibitors of the binding interaction.

The proteins provided by the present invention can similarly be used in assay to
determine biological activity, including in a panel of multiple proteins for high-throughput
5 screening; to raise antibodies or to elicit another immune response; as a reagent (including
the labeled reagent) in assays designed to quantitatively determine levels of the protein (or
its receptor) in biological fluids; as markers for tissues in which the corresponding protein
is preferentially expressed (either constitutively or at a particular stage of tissue
differentiation or development or in a disease state); and, of course, to isolate correlative

1 0 receptors or Uganda Where the protein binds or potentially binds to another protein (such
as, for example, in a receptor-ligand interaction) , the protein can be used to identify the
other protein with which binding occurs or to identify inhibitors of the binding interaction.
Proteins involved in these binding interactions can also be used to screen for peptide or
small molecule inhibitors or agonists of the binding interaction.

15 Any or all of these research utilities are capable of being developed into reagent

grade or kit format for commercialization as research products.

Methods for performing the uses listed above are well known to those skilled in the
art. References disclosing such methods include without limitation "Molecular Cloning: A
Laboratory Manual", 2d ed., Cold Spring Harbor Laboratory Press, Sambrook, J., E.F.

20 Fritsch and T. Maniatis eds., 1989, and "Methods in Enzymology: Guide to Molecular
Cloning Techniques", Academic Press, Berger, S.L. and A.R. Kimmel eds., 1987.

Nutritional Uses

Polynucleotides and proteins of the present invention can also be used as nutritional

2 5 sources or supplements. Such uses include without limitation use as a protein or amino acid

supplement, use as a carbon source, use as a nitrogen source and use as a source of
carbohydrate. - In such cases the protein or polynucleotide of the invention can be added to
the feed of a particular organism or can be administered as a separate solid or liquid
preparation, such as in the form of powder, pills, solutions, suspensions or capsules. In the

3 0 case of microorganisms, the protein or polynucleotide of the invention can be added to the

medium in or on which the microorganism is cultured.

Cytokine and Cell Proliferation/D ifferentiation Activity

64

WO 98/45437

PCT/US98/06956

A protein of the present invention may exhibit cytokine, cell proliferation (either
inducing or inhibiting) or cell differentiation (either inducing or inhibiting) activity or may
induce production of other cytokines in certain cell populations. Many protein factors
discovered to date, including all known cytokines, have exhibited activity in one or more
5 factor dependent cell proliferation assays, and hence the assays serve as a convenient
confirmation of cytokine activity. The activity of a protein of the present invention is
evidenced by any one of a number of routine factor dependent ceil proliferation assays for
ceil lines including, without limitation, 32D, DA2, DA1G, T10, B9, B9/1 1, BaF3, MC9/G,
M+ (preB M + ), 2E8, RB5, DAI, 123, T1165, HT2, CTLL2, TF-1, Mo7e and CMK.

10 The activity of a protein of the invention may, among other means, be measured

by the following methods:

Assays for T-cell or thymocyte proliferation include without limitation those
described in: Current Protocols in Immunology, Ed by J. E. Coligan, A.M. Kruisbeek,
D.H. Margulies, E.M. Shevach, W Strober, Pub. Greene Publishing Associates and Wiley-

1 5 Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3. 1-3.19; Chapter
7, Immunologic studies in Humans); Takai et ah, J. Immunol. 137:3494-3500, 1986;
Bertagnolli et al., J. Immunol. 145:1706-1712, 1990; Bertagnolli et al., Cellular
Immunology 133:327-341, 1991; Bertagnolli, et ah, J. Immunol. 149:3778-3783, 1992;
Bowman et al., J. Immunol. 152: 1756-1761, 1994.

2 0 Assays for cytokine production and/or proliferation of spleen cells, lymph node

cells or thymocytes include, without limitation, those described in: Polyclonal T cell
stimulation, Kruisbeek, A.M. and Shevach, E.M. In Current Protocols in Immunology.
J.E.e.a. Coligan eds. Vol 1 pp. 3.12.1-3.12.14, John Wiley and Sons, Toronto. 1994; and
Measurement of mouse and human Interferon y, Schreiber, R.D. In Current Protocols in

2 5 Immunology. J.E.e.a. Coligan eds. Vol 1 pp. 6.8.1-6.8.8, John Wiley and Sons, Toronto.

1994.

Assays for proliferation and differentiation of hematopoietic and lymphopoietic cells
include, without limitation, those described in: Measurement of Human and Murine
Interleukin 2 and Interleukin 4, Bottomly, K., Davis, L.S. and Lipsky, P.E. In Current

3 0 Protocols in Immunology. J.E.e.a. Coligan eds. Vol 1 pp. 6.3.1-6.3.12, John Wiley and

Sons, Toronto. 1991; deVries et al., J. Exp. Med. 173:1205-1211, 1991; Moreau et al.,
Nature 336:690-692, 1988; Greenberger et al., Proc. Natl. Acad. Sci. U.S.A.
80:2931-2938, 1983; Measurement of mouse and human interleukin 6 - Nordan, R. In
Current Protocols in Immunology. J.E.e.a. Coligan eds. Vol 1 pp. 6.6.1-6.6.5, John Wiley

65

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and Sons, Toronto. 1991; Smith etal., Proc. Natl. Acad. Sci. U.S.A. 83:1857-1861, 1986;
Measurement of human Interleukin 1 1 - Bennett, F., Giannotti, J., Clark, S.C. and Turner,
K. J. In Current Protocols in Immunology. J.E.e.a. Coligan eds. Vol 1 pp. 6.15.1 John
Wiley and Sons, Toronto. 1991; Measurement of mouse and human Interleukin 9 -
5 Ciarletta, A., Giannotti, J., Clark, S C. and Turner, K.J. In Current Protocols in
Immunology. J.E.e.a. Coligan eds. Vol 1 pp. 6. 13. 1, John Wiley and Sons, Toronto. 1991.

Assays for T-cell clone responses to antigens (which will identify, among others,
proteins that affect APC-T cell interactions as well as direct T-cell effects by measuring
proliferation and cytokine production) include, without limitation, those described in:

10 Current Protocols in Immunology, Ed by J. E. Coligan, A.M. Kruisbeek, D.H. Margulies,
E.M. Shevach, W Strober, Pub. Greene Publishing Associates and Wiley-Interscience
(Chapter 3, In Vitro assays for Mouse Lymphocyte Function; Chapter 6, Cytokines and
their cellular receptors; Chapter 7, Immunologic studies in Humans); Weinberger et al.,
Proc. Natl. Acad. Sci. USA 77:6091-6095, 1980; Weinberger et al., Eur. J. Immun.

15 11:405-411, 1981; Takai et al., J. Immunol. 137:3494-3500, 1986; Takai et al., J.
Immunol. 140:508-512, 1988.

Immune Stim ulating pr Suppressing Activity

A protein of the present invention may also exhibit immune stimulating or immune

2 0 suppressing activity, including without limitation the activities for which assays are

described herein. A protein may be useful in the treatment of various immune deficiencies
and disorders (including severe combined immunodeficiency (SCID)), e.g., in regulating
(up or down) growth and proliferation of T and/or B lymphocytes, as well as effecting the
cytolytic activity of NK cells and other cell populations. These immune deficiencies may
25 be genetic or be caused by viral (e.g. , HIV) as well as bacterial or fungal infections, or may
result from autoimmune disorders. More specifically, infectious diseases causes by viral,
bacterial, fungal or other infection may be treatable using a protein of the present
invention, including infections by HIV, hepatitis viruses, herpesviruses, mycobacteria,
Leishmania spp., malaria spp. and various fungal infections such as candidiasis. Of course,

3 0 in this regard, a protein of the present invention may also be useful where a boost to the

immune system generally may be desirable, i.e., in the treatment of cancer.

Autoimmune disorders which may be treated using a protein of the present
invention include, for example, connective tissue disease, multiple sclerosis, systemic lupus
erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre

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syndrome, autoimmune thyroiditis, insulin dependent diabetes mellitis, myasthenia gravis,
graft- versus-host disease and autoimmune inflammatory eye disease. Such a protein of the
present invention may also to be useful in the treatment of allergic reactions and conditions,
such as asthma (particularly allergic asthma) or other respiratory problems. Other
5 conditions, in which immune suppression is desired (including, for example, organ
transplantation), may also be treatable using a protein of the present invention.

Using the proteins of the invention it may also be possible to immune responses,
in a number of ways. Down regulation may be in the form of inhibiting or blocking an
immune response already in progress or may involve preventing the induction of an immune

10 response. The functions of activated T cells may be inhibited by suppressing T cell
responses or by inducing specific tolerance in T cells, or both. Immunosuppression of T
cell responses is generally an active, non- antigen-specific, process which requires
continuous exposure of the T cells to the suppressive agent. Tolerance, which involves
inducing non-responsiveness or anergy in T cells, is distinguishable from

15 immunosuppression in that it is generally antigen-specific and persists after exposure to the
tolerizing agent has ceased. Operationally, tolerance can be demonstrated by the lack of
a T cell response upon reexposure to specific antigen in the absence of the tolerizing agent.

Down regulating or preventing one or more antigen functions (including without
limitation B lymphocyte antigen functions (such as , for example, B7)), e.g., preventing

2 0 high. level lymphokine synthesis by activated T cells, will be useful in situations of tissue,
skin and organ transplantation and in graft- versus-host disease (GVHD). For example,
blockage of T cell function should result in reduced tissue destruction in tissue
transplantation. Typically, in tissue transplants, rejection of the transplant is initiated
through its recognition as foreign by T cells, followed by an immune reaction that destroys

2 5 the transplant. The administration of a molecule which inhibits or blocks interaction of a

B7 lymphocyte antigen with its natural ligand(s) on immune cells (such as a soluble,
monomeric form of a peptide having B7-2 activity alone or in conjunction with a
monomeric form of a peptide having an activity of another B lymphocyte antigen (e.g., B7-
1, B7-3) or blocking antibody), prior to transplantation can lead to the binding of the

3 0 molecule to the natural ligand(s) on the immune cells without transmitting the corresponding

costimulatory signal. Blocking B lymphocyte antigen function in this matter prevents
cytokine synthesis by immune cells, such as T cells, and thus acts as an immunosuppressant
Moreover, the lack of costimulationmay also be sufficient to anergize the T cells, thereby
inducing tolerance in a subject. Induction of long-term tolerance by B lymphocyte antigen-

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blocking reagents may avoid the necessity of repeated administration of these blocking
reagents. To achieve sufficient immunosuppression or tolerance in a subject, it may also
be necessary to block the function of a combination of B lymphocyte antigens.

The efficacy of particular blocking reagents in preventing organ transplant rejection
5 or GVHD can be assessed using animal models that are predictive of efficacy in humans.
Examples of appropriate systems which can be used include allogeneic cardiac grafts in rats
and xenogeneic pancreatic islet cell grafts in mice, both of which have been used to
examine the immunosuppressive effects of CTLA41g fusion proteins in vivo as described
in Lenschow et aL p Science 257:789-792 (1992) and Turka etal. t Proc. Natl. Acad. Sci
10 USA, (59:11102-11105 (1992). In addition, murine models of GVHD (see Paul ed..
Fundamental Immunology, Raven Press, New York, 1989, pp. 846-847) can be used to
determine the effect of blocking B lymphocyte antigen function in vivo on the development
of that disease.

Blocking antigen function may also be therapeutically useful for treating
1 5 autoimmune diseases. Many autoimmune disorders are the result of inappropriate activation
of T cells that are reactive against self tissue and which promote the production of cytokines
and autoantibodies involved in the pathology of the diseases. Preventing the activation of
autoreactive T cells may reduce or eliminate disease symptoms. Administration of reagents
which block costimulation of T cells by disrupting receptor: ligand interactions of B
20 lymphocyte antigens can be used to inhibit T cell activation and prevent production of
autoantibodies or T cell-derived cytokines which may be involved in the disease process.
Additionally, blocking reagents may induce antigen-specific tolerance of autoreactive T cells
which could lead to long-term relief from the disease. The efficacy of blocking reagents
in preventing or alleviating autoimmune disorders can be determined using a number of

2 5 well-characterized animal models of human autoimmune diseases. Examples include

murine experimental autoimmune encephalitis, systemic lupus erythmatosis in MRL/lpr/lpr
mice or NZB hybrid mice, murine autoimmune collagen arthritis, diabetes mellitus in NOD
mice and BB rats, and murine experimental myasthenia gravis (see Paul ed. , Fundamental
Immunology, Raven Press, New York, 1989, pp. 840-856).

3 0 Upregulationof an antigen function (preferably a B lymphocyte antigen function),

as a means of up regulating immune responses, may also be useful in therapy.
Upregulation of immune responses may be in the form of enhancing an existing immune
response or eliciting an initial immune response. For example, enhancing an immune
response through stimulating B lymphocyte antigen function may be useful in cases of viral

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infection. In addition, systemic viral diseases such as influenza, the common cold, and
encephalitis might be alleviated by the administration of stimulatory forms of B lymphocyte
antigens systemically.

Alternatively, anti-viral immune responses may be enhanced in an infected patient
5 by removing T cells from the patient, costimulating the T cells in vitro with viral antigen-
pulsed APCs either expressing a peptide of the present invention or together with a
stimulatory form of a soluble peptide of the present invention and reintroducing the in vitro
activated T cells into the patient. Another method of enhancing anti-viral immune responses
would be to isolate infected cells from a patient, transfect them with a nucleic acid encoding

10 a protein of the present invention as described herein such that the ceils express ail or a
portion of the protein on their surface, and reintroduce the transfected cells into the patient.
The infected cells would now be capable of delivering a costimulatory signal to, and thereby
activate, T cells in vivo.

In another application, up regulation or enhancement of antigen function (preferably

15 B lymphocyte antigen function) may be useful in the induction of tumor immunity. Tumor
cells (e.g., sarcoma, melanoma, lymphoma, leukemia, neuroblastoma, carcinoma)
transfected with a nucleic acid encoding at least one peptide of the present invention can be
administered to a subject to overcome tumor-specific tolerance in the subject. If desired,
the tumor cell can be transfected to express a combination of peptides. For example, tumor

2 0 cells obtained from a patient can be transfected ex vivo with an expression vector directing

the expression of a peptide having B7-2-like activity alone, or in conjunction with a peptide
having B7-l-like activity and/or B7~3-like activity. The transfected tumor cells are returned
to the patient to result in expression of the peptides on the surface of the transfected cell.
Alternatively, gene therapy techniques can be used to target a tumor ceil for transfection
25 in vivo.

The presence of the peptide of the present invention having the activity of a B
lymphocyte antigen(s) on the surface of the tumor cell provides the necessary costimulation
signal to T cells to induce a T cell mediated immune response against the transfected tumor
cells. In addition, tumor cells which lack MHC class I or MHC class II molecules, or

3 0 which fail to reexpress sufficient amounts of MHC class I or MHC class II molecules, can

be transfected with nucleic acid encoding all or a portion of (e.g., a cytopiasmic-domain
truncated portion) of an MHC class I a chain protein and p 2 microglobulin protein or an
MHC class II a chain protein and an MHC class II p chain protein to thereby express MHC
class I or MHC class II proteins on the cell surface. Expression of the appropriate class I

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or class II MHC in conjunction with a peptide having the activity of a B lymphocyte antigen
(<?,£. ,B7-i, B7-2, B7-3) induces a T cell mediated immune response against the transfected
tumor cell. Optionally, a gene encoding an antisense construct which blocks expression of
an MHC class II associated protein, such as the invariant chain, can also be cotransfected
5 with a DNA encoding a peptide having the activity of a B lymphocyte antigen to promote
presentation of tumor associated antigens and induce tumor specific immunity. Thus, the
induction of a T cell mediated immune response in a human subject may be sufficient to
overcome tumor-specific tolerance in the subject.

The activity of a protein of the invention may, among other means, be measured

10 by the following methods:

Suitable assays for thymocyte or splenocyte cytotoxicity include, without limitation,
those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A.M.
Kruisbeek, D.H. Margulies, E.M. Shevach, W Strober, Pub. Greene Publishing Associates
and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-

15 3. 19; Chapter 7, Immunologic studies in Humans); Herrmann et al., Proc. Natl. Acad. Sci.
USA 78:2488-2492, 1981; Herrmann et al., J. Immunol. 128:1968-1974, 1982; Handa
et al., J. Immunol. 135:1564*1572, 1985; Takai et al., J. Immunol. 137:3494-3500, 1986;
Takai et al., J. Immunol. 140:508-512, 1988; Herrmann et al., Proc. Natl. Acad. Sci.
USA 78:2488-2492, 1981; Herrmann et al., J. Immunol. 128:1968-1974, 1982; Handa

2 0 etal., J. Immunol. 135: 1564-1572, 1985; Takai et al., J. Immunol. 137:3494-3500, 1986;

Bowmanet al., J. Virology 61: 1992-1998; Takai et al., J. Immunol. 140:508-512, 1988;
Bertagnolli et al., Cellular Immunology 133:327-341, 1991; Brown et al., J. Immunol.
153:3079-3092, 1994.

Assays for T-cell-dependent immunoglobulin responses and isotype switching
25 (which will identify, among others, proteins that modulate T-cell dependent antibody
responses and that affect Thl/Th2 profiles) include, without limitation, those described in:
Maliszewski, J. Immunol. 144:3028-3033, 1990; and Assays for B cell function: In vitro
antibody production, Mond, J.J. and Brunswick, M. In Current Protocols in Immunology.
J.E.e.a. Coligan eds. Vol 1 pp. 3.8.1-3.8.16, John Wiley and Sons, Toronto, 1994.

3 0 Mixed lymphocyte reaction (MLR) assays (which will identify, among others,

proteins that generate predominantly Thl and CTL responses) include, without limitation,
those described in: Current Protocols in Immunology, Ed by J. E. Coligan, A.M.
Kruisbeek, D.H. Margulies, E.M. Shevach, W Strober, Pub. Greene Publishing Associates
and Wiley-Interscience (Chapter 3, In Vitro assays for Mouse Lymphocyte Function 3.1-

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3.19; Chapter 7, Immunologic studies in Humans); Takai et al., J. Immunol.
137:3494-3500, 1986; Takaietal., J. Immunol. 140:508-512, 1988; Bertagnolli et al., J.
Immunol. 149:3778-3783, 1992.

Dendritic cell-dependent assays (which will identify, among others, proteins
5 expressed by dendritic cells that activate naive T-ceils) include, without limitation, those
described in: Guery et al., J. Immunol. 134:536-544, 1995; Inaba et al., Journal of
Experimental Medicine 173:549-559, 1991: Macatonia et al., Journal of Immunology
154:5071-5079, 1995; Porgador et al., Journal of Experimental Medicine 182:255-260,
1995; Nair et al., Journal of Virology 67:4062-4069, 1993; Huang et al.. Science

10 264:961-965, 1994; Macatonia et al., Journal of Experimental Medicine 169:1255-1264,
1989; Bhardwaj et al.. Journal of Clinical Investigation 94:797-807, 1994; and Inaba et al.,
Journal of Experimental Medicine 172:631-640, 1990.

Assays for lymphocyte survival/apoptosis (which will identify, among others,
proteins that prevent apoptosis after superantigen induction and proteins that regulate

15 lymphocyte homeostasis) include, without limitation, those described in: Darzynkiewicz et
al., Cytometry 13:795-808, 1992; Gorczyca et al., Leukemia 7:659-670, 1993; Gorczyca
et aL, Cancer Research 53:1945-1951, 1993; Itoh et al., Cell 66:233-243, 1991;
Zacharchuk, Journal of Immunology 145:4037-4045, 1990; Zamai et al., Cytometry
14:891-897, 1993; Gorczyca et al., International Journal of Oncology 1:639-648, 1992.

2 0 Assays for proteins that influence early steps of T-cell commitment and

development include, without limitation, those described in: Antica et al., Blood
84: 1 1 1-117, 1994; Fine et al., Cellular Immunology 155: 1 1 1-122, 1994; Galy et al.. Blood
85:2770-2778, 1995; Toki et al., Proc. Nat. Acad Sci. USA 88:7548-7551, 1991.

25 HematopQjesi5 Reg u lati ng Activity

A protein of the present invention may be useful in regulation of hematopoiesis and,
consequently^ in the treatment of myeloid or lymphoid cell deficiencies. Even marginal
biological activity in support of colony forming cells or of factor-dependent cell lines
indicates involvement in regulating hematopoiesis, e.g. in supporting the growth and

3 0 proliferation of erythroid progenitor cells alone or in combination with other cytokines,

thereby indicating utility, for example, in treating various anemias or for use in conjunction
with irradiation/chemotherapy to stimulate the production of erythroid precursors and/or
erythroid cells; in supporting the growth and proliferation of myeloid cells such as
granulocytes and monocytes/macrophages (i.e., traditional CSF activity) useful, for

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example, in conjunction with chemotherapy to prevent or treat consequent myelo-
suppression; in supporting the growth and proliferation of megakaryocytes and consequently
of platelets thereby allowing prevention or treatment of various platelet disorders such as
thrombocytopenia, and generally for use in place of or complimentary to platelet
5 transfusions; and/or in supporting the growth and proliferation of hematopoietic stem cells
which are capable of maturing to any and all of the above-mentioned hematopoietic cells
and therefore find therapeutic utility in various stem cell disorders (such as those usually
treated with transplantation, including, without limitation, aplastic anemia and paroxysmal
nocturnal hemoglobinuria), as well as in repopulating the stem cell compartment post

10 irradiation/chemotherapy, either in-vivo or ex-vivo (i.e., in conjunction with bone marrow
transplantation or with peripheral progenitor cell transplantation (homologous or
heterologous)) as norma! cells or genetically manipulated for gene therapy.

The activity of a protein of the invention may, among other means, be measured
by the following methods:

15 Suitable assays for proliferation and differentiation of various hematopoietic lines

are cited above.

Assays for embryonic stem cell differentiation (which will identify, among others,
proteins that influence embryonic differentiation hematopoiesis) include, without limitation,
those described in: Johansson et al. Cellular Biology 15:141-151, 1995; Keller et al.,
2 0 Molecular and Cellular Biology 13:473-486, 1993; McClanahan et al., Blood
81:2903-2915, 1993.

Assays for stem cell survival and differentiation (which will identify, among others,
proteins that regulate lympho-hematopoiesis) include, without limitation, those described
in: Methylcellulose colony forming assays, Freshney, M.G. In Culture of Hematopoietic

2 5 Cells. R.L Freshney, et al. eds. Vol pp. 265-268, Wiley-Liss, Inc., New York, NY. 1994;

Hirayamaet al., Proc. Natl. Acad. Sci. USA 89:5907-591 1, 1992; Primitive hematopoietic
colony forming cells with high proliferative potential, McNiece, I.K. and Briddell, R.A.
In Culture of Hematopoietic Cells. R.I. Freshney, et al. eds. Vol pp. 23-39, Wiley-Liss,
Inc., New York, NY. 1994; Neben et al., Experimental Hematology 22:353-359, 1994;

3 0 Cobblestone area forming cell assay, Ploemacher, R.E. In Culture of Hematopoietic Cells.

R.L Freshney, et al. eds. Vol pp. 1-21, Wiley-Liss, Inc., New York, NY. 1994; Long
term bone marrow cultures in the presence of stromal cells, Spooncer, E., Dexter, M. and
Allen, T. In Culture of Hematopoietic Cells. R.L Freshney, et al. eds. Vol pp. 163-179,
Wiley-Liss, Inc., New York, NY. 1994; Long term culture initiating cell assay, Sutherland,

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H.J. In Culture of Hematopoietic Cells. R.I. Freshney, et al. eds. Vol pp. 139-162,
Wiley-Liss, Inc., New York, NY. 1994.

Tissue Growth Activity

5 A protein of the present invention also may have utility in compositions used for

bone, cartilage, tendon, ligament and/or nerve tissue growth or regeneration, as well as for
wound healing and tissue repair and replacement, and in the treatment of burns, incisions
and ulcers.

A protein of the present invention, which induces cartilage and/or bone growth in
1 0 circumstances where bone is not normally formed, has application in the healing of bone
fractures and cartilage damage or defects in humans and other animals. Such a preparation
employing a protein of the invention may have prophylactic use in closed as well as open
fracture reduction and also in the improved fixation of artificial joints. De novo bone
formation induced by an osteogenic agent contributes to the repair of congenital, trauma
15 induced, or oncologic resection induced craniofacial defects, and also is useful in cosmetic
plastic surgery.

A protein of this invention may also be used in the treatment of periodontal disease,
and in other tooth repair processes. Such agents may provide an environment to attract
bone-forming cells, stimulate growth of bone-forming cells or induce differentiation of
2 0 progenitors of bone-forming cells. A protein of the invention may also be useful in the
treatment of osteoporosis or osteoarthritis, such as through stimulation of bone and/or
cartilage repair or by blocking inflammation or processes of tissue destruction (collagenase
activity, osteoclast activity, etc.) mediated by inflammatory processes.

Another category of tissue regeneration activity that may be attributable to the

2 5 protein of the present invention is tendon/ ligament formation. A protein of the present

invention, which induces tendon/ligament-like tissue or other tissue formation in
circumstances where such tissue is not normally formed, has application in the healing of
tendon or ligament tears, deformities and other tendon or ligament defects in humans and
other animals. Such a preparation employing a tendon/Iigament-liketissue inducing protein

3 0 may have prophylactic use in preventing damage to tendon or ligament tissue, as well as use

in the improved fixation of tendon or ligament to bone or other tissues, and in repairing
defects to tendon or ligament tissue. De novo tendon/Iigament-liketissue formation induced
by a composition of the present invention contributes to the repair of congenital, trauma
induced, or other tendon or ligament defects of other origin, and is also useful in cosmetic

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plastic surgery for attachment or repair of tendons or ligaments. The compositions of the
present invention may provide an environment to attract tendon- or ligament-forming cells,
stimulate growth of tendon- or ligament-forming cells, induce differentiation of progenitors
of tendon- or ligament-forming cells, or induce growth of tendon/ligament cells or
5 progenitors ex vivo for return in vivo to effect tissue repair. The compositions of the
invention may also be useful in the treatment of tendinitis, carpal tunnel syndrome and other
tendon or ligament defects. The compositions may also include an appropriate matrix
and/or sequestering agent as a carrier as is well known in the art.

The protein of the present invention may also be useful for proliferation of neural

10 cells and for regeneration of nerve and brain tissue, i.e. for the treatment of central and
peripheral nervous system diseases and neuropathies, as well as mechanical and traumatic
disorders , which involve degeneration, death or trauma to neural cells or nerve tissue-
More specifically, a protein may be used in the treatment of diseases of the peripheral
nervous system, such as peripheral nerve injuries, peripheral neuropathy and localized

15 neuropathies, and central nervous system diseases, such as Alzheimer's, Parkinson's
disease, Huntington's disease, amyotrophic lateral sclerosis, and Shy-Drager syndrome.
Further conditions which may be treated in accordance with the present invention include
mechanical and traumatic disorders, such as spinal cord disorders, head trauma and
cerebrovascular diseases such as stroke. Peripheral neuropathies resulting from

20 chemotherapy or other medical therapies may also be treatable using a protein of the
invention.

Proteins of the invention may also be useful to promote better or faster closure of
non-healing wounds, including without limitation pressure ulcers, ulcers associated with
vascular insufficiency, surgical and traumatic wounds, and the like.

2 5 It is expected that a protein of the present invention may also exhibit activity for

generation or regeneration of other tissues, such as organs (including, for example,
pancreas, liver, intestine, kidney, skin, endothelium), muscle (smooth, skeletal or cardiac)
and vascular (including vascular endothelium) tissue, or for promoting the growth of ceils
comprising such tissues. Part of the desired effects may be by inhibition or modulation of

3 0 fibrotic scarring to allow normal tissue to regenerate. A protein of the invention may also

exhibit angiogenic activity.

A protein of the present invention may also be useful for gut protection or
regeneration and treatment of lung or liver fibrosis, reperfusion injury in various tissues,
and conditions resulting from systemic cytokine damage.

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A protein of the present invention may also be useful for promoting or inhibiting
differentiation of tissues described above from precursor tissues or cells; or for inhibiting
the growth of tissues described above.

The activity of a protein of the invention may, among other means, be measured
5 by the following methods:

Assays for tissue generation activity include, without limitation, those described in:
International Patent Publication No, WO95/16035 (bone, cartilage, tendon); International
Patent Publication No. WO95/05846 (nerve, neuronal); International Patent Publication No.
W09 1/07491 (skin, endothelium ).
10 Assays for wound healing activity include, without limitation, those described in:

Winter, Epidermal Wound Healing , pps. 71-1 12 (Maibach, HI and Rovee, DT, eds.), Year
Book Medical Publishers, Inc., Chicago, as modified by Eaglstein and Mertz, J. Invest.
Dermatol 71:382-84 (1978).

15 Activin/Inhi frin Activit y

A protein of the present invention may also exhibit activin- or inhibin-related
activities. Inhibins are characterized by their ability to inhibit the release of follicle
stimulating hormone (FSH), while activins and are characterized by their ability to stimulate
the release of follicle stimulating hormone (FSH), Thus, a protein of the present invention,

20 alone or in heterodimers with a member of the inhibin a family, may be useful as a
contraceptive based on the ability of inhibins to decrease fertility in female mammals and
decrease spermatogenesis in male mammals. Administration of sufficient amounts of other
inhibins can induce infertility in these mammals. Alternatively, the protein of the inventioa
as a homodimer or as a heterodimer with other protein subunits of the inhibin-p group, may

2 5 be useful as a fertility inducing therapeutic, based upon the ability of activin molecules in

stimulating FSH release from cells of the anterior pituitary. See, for example, United States
Patent 4,798,885. A protein of the invention may also be useful for advancement of the
onset of fertility in sexually immature mammals, so as to increase the lifetime reproductive
performance of domestic animals such as cows, sheep and pigs.

3 0 The activity of a protein of the invention may, among other means, be measured

by the following methods:

Assays for activin/inhibin activity include, without limitation, those described in:
Vale et aL, Endocrinology 91:562-572, 1972; Ling et al., Nature 321:779-782, 1986; Vale

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etal.. Nature 321:776-779, 1986; Mason et al., Nature 318:659-663, 1985; Forage et al.,
Proc. Natl. Acad. Sci. USA 83:3091-3095, 1986.

Chemotactic/Chemokinetic Activity
5 A protein of the present invention may have chemotactic or chemokinetic activity

(e.g., act as a chemokine) for mammalian cells, including, for example, monocytes,
fibroblasts, neutrophils, T-ceiis, mast ceils, eosinophils, epithelial and/or endothelial cells.
Chemotactic and chemokinetic proteins can be used to mobilize or attract a desired cell
population to a desired site of action. Chemotactic or chemokinetic proteins provide

10 particular advantages in treatment of wounds and other trauma to tissues, as well as in
treatment of localized infections. For example, attraction of lymphocytes, monocytes or
neutrophils to tumors or sites of infection may result in improved immune responses against
the tumor or infecting agent.

A protein or peptide has chemotactic activity for a particular cell population if it can

15 stimulate, directly or indirectly, the directed orientation or movement of such cell
population. Preferably, the protein or peptide has the ability to directly stimulate directed
movement of cells. Whether a particular protein has chemotactic activity for a population
of cells can be readily determined by employing such protein or peptide in any known assay
for cell chemotaxis.

2 0 The activity of a protein of the invention may, among other means, be measured

by the following methods:

Assays for chemotactic activity (which will identify proteins that induce or prevent
chemotaxis) consist of assays that measure the ability of a protein to induce the migration
of cells across a membrane as well as the ability of a protein to induce the adhesion of one

2 5 cell population to another cell population. Suitable assays for movement and adhesion

include, without limitation, those described in: Current Protocols in Immunology, Ed by
J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, W.Strober, Pub. Greene
Publishing Associates and Wiley-Interscience (Chapter 6.12, Measurement of alpha and
betaChemokines6.12.1-6.12.28;Taubet al. J. Clin. Invest. 95:1370-1376, 1995; Lind et

3 0 al. APMIS 103:140-146, 1995; Mulleret al Eur. J. Immunol. 25: 1744-1748; Gruber et al.

J. of Immunol. 152:5860-5867, 1994; Johnston et al. J. of Immunol. 153; 1762-1768, 1994.

Hemostatic and Thrombolytic Activity

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A protein of the invention may also exhibit hemostatic or thrombolytic activity. As
a result, such a protein is expected to be useful in treatment of various coagulation disorders
(including hereditary disorders, such as hemophilias) or to enhance coagulation and other
hemostatic events in treating wounds resulting from trauma, surgery or other causes. A
5 protein of the invention may also be useful for dissolving or inhibiting formation of
thromboses and for treatment and prevention of conditions resulting therefrom (such as, for
example, infarction of cardiac and central nervous system vessels (e.g., stroke).

The activity of a protein of the invention may, among other means, be measured
by the following methods:
1 0 Assay for hemostatic and thrombolytic activity include, without limitation, those

described in; Linet et al., J. Clin. Pharmacol. 26:131-140, 1986; Burdick et al.,
Thrombosis Res. 45:413-419, 1987; Humphrey et al., Fibrinolysis 5:71-79 (1991); Schaub,
Prostaglandins 35:467-474, 1988.

15 Receptor/Ligand Activity

A protein of the present invention may also demonstrate activity as receptors,
receptor ligands or inhibitors or agonists of receptor/1 igand interactions. Examples of such
receptors and ligands include, without limitation, cytokine receptors and their ligands,
receptor kinases and their ligands, receptor phosphatases and their ligands, receptors

2 0 involved in cell-cell interactions and their ligands (including without limitation, cellular
adhesion molecules (such as selectins, integrins and their ligands) and receptor/ligand pairs
involved in antigen presentation, antigen recognition and development of cellular and
humoral immune responses). Receptors and ligands are also useful for screening of
potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction.

2 5 A protein of the present invention (including, without limitation, fragments of receptors and

ligands) may themselves be useful as inhibitors of receptor/ligand interactions.

The activity of a protein of the invention may, among other means, be measured
by the following methods:

Suitable assays for receptor-ligand activity include without limitation those

3 0 described in: Current Protocols in Immunology, Ed by J.E. Coligan, A.M. Kruisbeek, D.H.

Margulies, E.M. Shevach, W.Strober, Pub. Greene Publishing Associates and
Wiley-Interscience (Chapter 7.28, Measurement of Cellular Adhesion under static
conditions7.28.1-7.28.22),Takaietal., Proc. Natl. Acad. Sci. USA 84:6864-6868, 1987;
Bierer et al., J. Exp. Med. 168:1145-1156, 1988; Rosenstein et al., J. Exp. Med.

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169:149-160 1989; Stoltenborget al., J. Immunol. Methods 175:59-68, 1994; Stittetal.,
Cell 80:661-670, 1995.

Antiinflammatory Activity
5 Proteins of the present invention may also exhibit anti-inflammatory activity . The

anti-inflammatory activity may be achieved by providing a stimulus to cells involved in the
inflammatory response, by inhibiting or promoting cell-cell interactions (such as, for
example, cell adhesion), by inhibiting or promoting chemotaxis of cells involved in the
inflammatory process, inhibiting or promoting cell extravasation, or by stimulating or

10 suppressing production of other factors which more directly inhibit or promote an
inflammatory response. Proteins exhibiting such activities can be used to treat
inflammatory conditions including chronic or acute conditions), including without limitation
inflammation associated with infection (such as septic shock, sepsis or systemic
inflammatory response syndrome (SIRS)), ischemia-reperfusion injury, endotoxin lethality,

15 arthritis, complement-mediated hyperacute rejection, nephritis, cytokine or chemokine-
induced lung injury, inflammatory bowel disease, Crohn's disease or resulting from over
production of cytokines such as TNF or IL-1 . Proteins of the invention may also be useful
to treat anaphylaxis and hypersensitivity to an antigenic substance or material.

20 Tumor Inhibition Activity

In addition to the activities described above for immunological treatment or
prevention of tumors, a protein of the invention may exhibit other anti-tumor activities. A
protein may inhibit tumor growth directly or indirectly (such as, for example, via ADCC).
A protein may exhibit its tumor inhibitory activity by acting on tumor tissue or tumor

2 5 precursor tissue, by inhibiting formation of tissues necessary to support tumor growth (such
as, for example, by inhibiting angiogenesis), by causing production of other factors, agents
or cell types which inhibit tumor growth, or by suppressing, eliminating or inhibiting
factors, agents or cell types which promote tumor growth.

30

Other Activities

A protein of the invention may also exhibit one or more of the following additional
activities or effects; inhibiting the growth, infection or function of, or killing, infectious
agents, including, without limitation, bacteria, viruses, fungi and other parasites; effecting

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(suppressing or enhancing) bodily characteristics, including, without limitation, height,
weight, hair color, eye color, skin, fat to lean ratio or other tissue pigmentation, or organ
or body part size or shape (such as, for example, breast augmentation or diminution, change
in bone form or shape); effecting biorhythms or caricadic cycles or rhythms; effecting the
5 fertility of male or female subjects; effecting the metabolism, catabolism, anabolism,
processing, utilization, storage or elimination of dietary fat, lipid, protein, carbohydrate,
vitamins, minerals* cofactors or other nutritional factors or component(s); effecting
behavioral characteristics, including, without limitation, appetite, libido, stress, cognition
(including cognitive disorders), depression (including depressive disorders) and violent

10 behaviors; providing analgesic effects or other pain reducing effects; promoting
differentiation and growth of embryonic stem cells in lineages other than hematopoietic
lineages; hormonal or endocrine activity; in the case of enzymes, correcting deficiencies
of the enzyme and treating deficiency- related diseases; treatment of hyperproliferative
disorders (such as, for example, psoriasis); immunoglobulin-like activity (such as, for

15 example, the ability to bind antigens or complement); and the ability to act as an antigen in
a vaccine composition to raise an immune response against such protein or another material
or entity which is cross-reactive with such protein.

20

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ADMINISTRATION AND DOSING

A protein of the present invention (from whatever source derived, including without
limitation from recombinant and non-recombinant sources) may be used in a pharmaceutical
composition when combined with a pharmaceutical ly acceptable carrier. Such a
5 composition may also contain (in addition to protein and a carrier) diluents, fillers, salts,
buffers, stabilizers, solubilizers, and other materials well known in the art. The term
"pharmaceutically acceptable" means a non-toxic material that does not interfere with the
effectiveness of the biological activity of the active ingredient(s). The characteristics of the
carrier will depend on the route of administratbn. The pharmaceutical composition of the

1 0 invention may also contain cytokines, lymphokines, or other hematopoietic factors such as
M-CSF, GM-CSF, TNF, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, 1L-7, IL-8, IL-9, IL-10, IL-11,
IL-12, IL-13, IL-14, IL-15, IFN, TNFO, TNF1, TNF2, G-CSF, Meg-CSF, thrombopoietia
stem cell factor, and erythropoietin. The pharmaceutical composition may further contain
other agents which either enhance the activity of the protein or compliment its activity or

15 use in treatment. Such additional factors and/or agents may be included in the
pharmaceutical composition to produce a synergistic effect with protein of the invention,
or to minimize side effects. Conversely, protein of the present invention may be included
in formulations of the particular cytokine, lymphokine, other hematopoietic factor,
thrombolytic or anti-thrombotic factor, or anti-inflammaory agent to minimize side effects

20 of the cytokine, lymphokine, other hematopoietic factor, thrombolytic or anti-thrombotic
factor, or anti-inflammatory agent.

A protein of the present invention may be active in multimers (e.g., heterodimers
or homodimers) or complexes with itself or other proteins. As a result, pharmaceutical
compositions of the invention may comprise a protein of the invention in such multimeric

25 or complexed form.

The pharmaceutical composition of the invention may be in the form of a complex
of the protein(s) of present invention along with protein or peptide antigens. The protein
and/or peptide antigen will deliver a stimulatory signal to both B and T lymphocytes. B
lymphocytes will respond to antigen through their surface immunoglobulin receptor. T

3 0 lymphocytes will respond to antigen through the T cell receptor (TCR) following
presentation of the antigen by MHC proteins. MHC and structurally related proteins
including those encoded by class I and class II MHC genes on host cells will serve to
present the peptide antigen(s) to T lymphocytes. The antigen components could also be
supplied as purified MHC-peptide complexes alone or with co-stimulatory molecules that

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can directly signal T cells. Alternatively antibodies able to bind surface immunolgobulin
and other molecules on B cells as well as antibodies able to bind the TCR and other
molecules on T cells can be combined with the pharmaceutical composition of the inventioa

5 The pharmaceutical composition of the invention may be in the form of a liposome

in which protein of the present invention is combined, in addition to other pharmaceutical^
acceptable carriers, with amphipathic agents such as lipids which exist in aggregated form
as micelles, insoluble monolayers, liquid crystals, or lamellar layers in aqueous solution.
Suitable lipids for liposomal formulation include, without limitation, monoglycerides,
10 diglycerides, sulfatides, lysoiecithin, phospholipids, saponin, bile acids, and the like.
Preparation of such liposomal formulations is within the level of skill in the art, as
disclosed, for example, in U.S. Patent No, 4,235,871; U.S. Patent No. 4,501,728; U.S.
Patent No. 4,837,028; and U.S. Patent No. 4,737,323, ail of which are incorporated herein
by reference.

15 As used herein, the term "therapeutically effective amount" means the total amount

of each active component of the pharmaceutical composition or method that is sufficient to
show a meaningful patient benefit, i.e., treatment, healing, prevention or amelioration of
the relevant medical condition, or an increase in rate of treatment, healing, prevention or
amelioration of such conditions. When applied to an individual active ingredient,

2 0 administered alone, the term refers to that ingredient alone. When applied to a

combination, the term refers to combined amounts of the active ingredients that result in the
therapeutic effect, whether administered in combination, serially or simultaneously.

In practicing the method of treatment or use of the present invention, a
therapeutically effective amount of protein of the present invention is administered to a
25 mammal having a condition to be treated. Protein of the present invention may be
administered in accordance with the method of the invention either alone or in combination
with other therapies such as treatments employing cytokines, lymphokines or other
hematopoietic factors. When co-administered with one or more cytokines, lymphokines or
other hematopoietic factors, protein of the present invention may be administered either

3 0 simultaneously with the cytokine(s), lymphokine(s), other hematopoietic factor(s),

thrombolytic or antithrombotic factors, or sequentially. If administered sequentially, the
attending physician will decide on the appropriate sequence of administering protein of the
present invention in combination with cytokine(s), lymphokine(s), other hematopoietic
factor(s), thrombolytic or antithrombotic factors.

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Administration of protein of the present invention used in the pharmaceutical
composition or to practice the method of the present invention can be carried out in a
variety of conventional ways, such as oral ingestion, inhalation, topical application or
cutaneous, subcutaneous, intraperitoneal, parenteral or intravenous injection. Intravenous
5 administration to the patient is preferred.

When a therapeutically effective amount of protein of the present invention is
administered orally, protein of the present invention will be in the form of a tablet, capsule,
powder, solution or elixir. When administered in tablet form, the pharmaceutical
composition of the invention may additionally contain a solid carrier such as a gelatin or an

10 adjuvant. The tablet, capsule, and powder contain from about 5 to 95% protein of the
present invention, and preferably from about 25 to 90 % protein of the present invention.
When administered in liquid form, a liquid carrier such as water, petroleum, oils of animal
or plant origin such as peanut oil, mineral oil, soybean oil, or sesame oil, or synthetic oils
may be added. The liquid form of the pharmaceutical composition may further contain

15 physiological saline solution, dextrose or other saccharide solution, or glycols such as
ethylene glycol, propylene glycol or polyethylene glycol. When administered in liquid
form, the pharmaceutical composition contains from about 0.5 to 90% by weight of protein
of the present invention, and preferably from about 1 to 50% protein of the present
invention.

20 When a therapeutically effective amount of protein of the present invention is

administered by intravenous, cutaneous or subcutaneous injection, protein of the present
invention will be in the form of a pyrogen- free, parenteral ly acceptable aqueous solution.
The preparation of such parenterally acceptable protein solutions, having due regard to pH,
isotonicity, stability, and the like, is within the skill in the art. A preferred pharmaceutical

25 composition for intravenous, cutaneous, or subcutaneous injection should contain, in
addition to protein of the present invention, an isotonic vehicle such as Sodium Chloride
Injection, Ringer's Injection, Dextrose Injection, Dextrose and Sodium Chloride Injection,
Lactated Ringer's Injection, or other vehicle as known in the art. The pharmaceutical
composition of the present invention may also contain stabilizers, preservatives, buffers,

3 0 antioxidants, or other additives known to those of skill in the art.

The amount of protein of the present invention in the pharmaceutical composition
of the present invention will depend upon the nature and severity of the condition being
treated, and on the nature of prior treatments which the patient has undergone. Ultimately,
the attending physician will decide the amount of protein of the present invention with

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which to treat each individual patient. Initially, the attending physician will administer low
doses of protein of the present invention and observe the patient's response. Larger doses
of protein of the present invention may be administered until the optimal therapeutic effect
is obtained for the patient, and at that point the dosage is not increased further. It is
5 contemplated that the various pharmaceutical compositions used to practice the method of
the presentinvention should contain about 0.01 fxg to about 100 mg (preferably about 0. ing
to about 10 mg, more preferably about 0. 1 fig to about 1 mg) of protein of the present
invention per kg body weight.

The duration of intravenous therapy using the pharmaceutical composition of the

10 present invention will vary, depending on the severity of the disease being treated and the
condition and potential idiosyncratic response of each individual patient. It is contemplated
that the duration of each application of the protein of the present invention will be in the
range of 12 to 24 hours of continuous intravenous administration. Ultimately the attending
physician will decide on the appropriate duration of intravenous therapy using the

15 pharmaceutical composition of the present invention.

Protein of the invention may also be used to immunize animals to obtain polyclonal
and monoclonal antibodies which specifically react with the protein. Such antibodies may
be obtained using either the entire protein or fragments thereof as an immunogen. The
peptide immunogens additionally may contain a cysteine residue at the carboxyl terminus,

20 and are conjugated to a hapten such as keyhole limpet hemocyanin (KLH). Methods for
synthesizing such peptides are known in the art, for example, as in R.P. Merrifield, J.
Amer.Chem.Soc. 33, 2149-2154 (1963); J.L. Krscenansky, et a/., FEBS Lett. 2LL 10
(1987). Monoclonal antibodies binding to the protein of the invention may be useful
diagnostic agents for the immunodetection of the protein. Neutralizing monoclonal

25 antibodies binding to the protein may also be useful therapeutics for both conditions
associated with the protein and also in the treatment of some forms of cancer where
abnormal expression of the protein is involved. In the case of cancerous cells or leukemic
cells, neutralizing monoclonal antibodies against the protein may be useful in detecting and
preventing the metastatic spread of the cancerous cells, which may be mediated by the

3 0 protein.

For compositions of the present invention which are useful for bone, cartilage,
tendon or ligament regeneration, the therapeutic method includes administering the
composition topically, systematically, or locally as an implant or device. When
administered, the therapeutic composition for use in this invention is, of course, in a

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pyrogen-free, physiologically acceptable form. Further, the composition may desirably be
encapsulated or injected in a viscous form for delivery 10 the site of bone, cartilage or tissue
damage. Topical administration may be suitable for wound healing and tissue repair.
Therapeutically useful agents other than a protein of the invention which may also
5 optionally be included in the composition as described above, may alternatively or
additionally, be administered simultaneously or sequentially with the composition in the
methods of the invention. Preferably for bone and/or cartilage formation, the composition
would include a matrix capable of delivering the protein-containing composition to the site
of bone and/or cartilage damage, providing a structure for the developing bone and

10 cartilage and optimally capable of being resorbed into the body. Such matrices may be
formed of materials presently in use for other implanted medical applications.

The choice of matrix material is based on biocompatibility, biodegradability,
mechanical properties, cosmetic appearance and interface properties. The particular
application of the compositions will define the appropriate formulation. Potential matrices

15 for the compositions may be biodegradable and chemically defined calcium sulfate,
tricalciumphosphate,hydroxyapatite, poly lactic acid, poly gly colic acid and poly anhydrides
Other potential materials are biodegradable and biologically well-defined, such as bone or
dermal collagen. Further matrices are comprised of pure proteins or extracellular matrix
components. Other potential matrices are nonbiodegradable and chemically defined, such

2 0 as sintered hydroxapatite, bioglass, aluminates, or other ceramics. Matrices may be

comprised of combinations of any of the above mentioned types of material, such as
poly lactic acid and hydroxyapatite or collagen and tricalciumphosphate. The bioceramics
may be altered in composition, such as in calcium-aluminate-phosphate and processing to
alter pore size, particle size, particle shape, and biodegradability.
25 Presently preferred is a 50:50 (mole weight) copolymer of lactic acid and glycolic

acid in the form of porous particles having diameters ranging from 150 to 800 microns. In
some applications, it will be useful to utilize a sequestering agent, such as carboxy methyl
cellulose or autologous blood clot, to prevent the protein compositions from disassociating
from the matrix.

3 0 A preferred family of sequestering agents is cellulosic materials such as

alkyicelluloses(including hydroxyalkylcelluloses) including methylcelluiose,ethylcellulose,
hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropyl-methylcellulose, and
carboxymethylcellulose,the most preferred being cationic salts of carboxymethylcellulose
(CMC). Other preferred sequestering agents include hyaluronic acid, sodium alginate,

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poly(ethylene glycol), polyoxyethylene oxide, carboxyvinyl polymer and polyvinyl
alcohol). The amount of sequestering agent useful herein is 0.5-20 wt%, preferably 1-10
wt% based on total formulation weight, which represents the amount necessary to prevent
desorbtion of the protein from the polymer matrix and to provide appropriate handling of
5 the composition, yet not so much that the progenitor cells are prevented from infiltrating
the matrix, thereby providing the protein the opportunity to assist the osteogenic activity
of the progenitor cells.

In further compositions, proteins of the invention may be combined with other
agents beneficial to the treatment of the bone and/or cartilage defect, wound, or tissue in

1 0 question. These agents include various growth factors such as epidermal growth factor
(EGF), platelet derived growth factor (PDGF), transforming growth factors (TGF-a and
TGF-p), and insulin-like growth factor (IGF).

The therapeutic compositions are also presently valuable for veterinary applications.
Particularly domestic animals and thoroughbred horses, in addition to humans, are desired

15 patients for such treatment with proteins of the present invention.

The dosage regimen of a protein-containing pharmaceutical composition to be used
in tissue regeneration will be determined by the attending physician considering various
factors which modify the action of the proteins, e.g., amount of tissue weight desired to be
formed, the site of damage, the condition of the damaged tissue, the size of a wound, type

2 0 of damaged tissue (e.g. , bone), the patient's age, sex, and diet, the severity of any infection,
time of administration and other clinical factors. The dosage may vary with the type of
matrix used in the reconstitution and with inclusion of other proteins in the pharmaceutical
composition. For example, the addition of other known growth factors, such as IGF I
(insulin like growth factor I), to the final composition, may also effect the dosage. Progress

2 5 can be monitored by periodic assessment of tissue/bone growth and/or repair, for example,

X-rays, histomorphometric determinations and tetracycline labeling.

Polynucleotides of the present invention can also be used for gene therapy. Such
polynucleotides can be introduced either in vivo or ex vivo into cells for expression in a
mammalian subject. Polynucleotides of the invention may also be administered by other

3 0 known methods for introduction of nucleic acid into a cell or organism (including, without

limitation, in the form of viral vectors or naked DNA).

Cells may also be cultured ex vivo in the presence of proteins of the present
invention in order to proliferate or to produce a desired effect on or activity in such cells.
Treated cells can then be introduced in vivo for therapeutic purposes.

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Patent and literature references cited herein are incorporated by reference as if
set forth.

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Table 3

Sel.

Species

Tissue

Cell Type

AA

Human

Kidney

19-23wks., M/F pool of 5

AB

Human

Fetal Lung

Fetal Lung

AC

Human

Placenta

26yrs., 1 specimen

AD

Murine

Embryo

Fetal ES cells

AE

Murine

Spleen

Adult spleen

AF

Murine

Fetal Brain

Fetal Brain

AG

Murine

Fetal Brain

Fetal Brain

AH

Murine

Fetal Thymus

Fetal Thymus

AI

Human

Blood

Adult PBMC/THlor2

AJ

Human

Testes

10-61yrs., pool of 11

AK

Human

Kidney

19-23wks., M/F pool of 5

AL

Human

Neural

Adult Glioblastoma line TG-1

AM

Human

Kidney

19-23wks., M/F pool of 5

AN

Murine

Bone Marrow

Adult Stromal cell line FCM-4

AO

Murine

Thymus

Adult Subtr. Adult Thymus

AP

Human

Placenta

26yrs., 1 specimen

AQ

Human

Ovary

PA-1 Teratocarcinoma

AR

Human

Retina

16-75yrs., pool of 76

AS

Human

Brain

19-23wks., M/F pool of 5

AT

Human

Blood

Adult iymphocytes+dend. cells

AU

Human

Testes

10-61yrs., pool of 11

AV

Murine

Spleen

Adult spleen

AW

Human

Ovary

PA-1 Teratocarcinoma

AX

Human

Testes

10-61yrs., pool of 11

AY

Human

Retina

16-75yrs., pool of 76

AZ

Human

Colon

Caco~2 Adenocarcinoma

B

Human

Blood

PeripheralBloodMononuclearCell

BA

Human

Placenta

26yrs., 1 specimen

BB

Human

Blood

Adult PBMC/THlor2

BC

Murine

Embryo

Fetal ES cells

BD

Human

Kidney

19-23wks M M/F pool of 5

BE

Human

Blood

Adult PBMC/THlor2

BF

Human

Brain

19-23wks., M/F pool of 5

BG

Human

Brain

N/A

BH

Human

Ovary

PA-1 Teratocarcinoma

BI

Human

Kidney

1 9-23wks M M/F pool of 5

BJ

Human

Ovary

PA-1 Teratocarcinoma

BK

Human

Retina

16-75yrs., pool of 76

BL

Human

Testes

10-61yrs., pool of 11

BM

Human

Muscle

N/A

BN

Human

Placenta

26yrs., 1 specimen

BO

Human

Retina

16-75yrs., pool of 76

BP

Human

Kidney

19-23wks., M/F pool of 5

BQ

Human

Colon

Caco-2 Adenocarcinoma Caco2

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SUBSTITUTE SHEET (RULE 26)

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BR

Human

Kidney

19-23wks., M/F pool of 5

BS

Human

Pituitary

Adult Pituitary

BT

Human

Blood

Adult PBMC

BU

Human

Placenta

26yrs, ? 1 specimen

BV

Human

Brain

N/A

BW

Human

Blood

Adult PBMC

BX

Human

Ovary

PA-1 Teratocarcinoma

BY

Human

Blood

Adult PBMC/THlor2

BZ

Human

Kidney

19-23wks., M/F pool of 5

C

Human

Blood

PeripheralBloodMononuclearCell

CA

Murine

Embryo

Fetal ES cell embryoid bodies

CB

Human

Brain

19-23wks., M/F pool of 5

CC

Human

Brain

N/A

CD

Human

Brain

19-23wks., M/F pool of 5

CE

Human

Blood

Adult lymphocytes+dend. cells

CF

Human

Placenta

26yrs., 1 specimen

CG

Human

Testes

10-6 lyrs., pool of 11

CH

Human

Kidney

19-23wks., M/F pool of 5

CI

Human

Brain

N/A

CJ

Human

Brain

19-23wks., M/F pool of 5

CK

Human

Testes

10-6 lyrs., pool of 11

CL

Human

Retina

16-75yrs., pool of 76

CM

Human

Adult Lung

Adult Lung

CN

Human

Brain

19~23wks., M/F pool of 5

CO

Human

Brain

N/A

CP

Human

SalivaryGland

N/A

CQ

Human

Heart

13-73yrs., pool of 3

CR

Human

Testes

10-61yrs., pool of 11

CS

Human

Brain

19-23wks., M/F pool of 5

CT

Human

Brain

N/A

CU

Human

Pineal Gland

N/A

CV

Human

Mammary

Adult Human Mammary

CW

Human

Brain

19-23wks., M/F pool of 5

CY

Human

Pineal Gland

N/A

CZ

Human

Testes

10-6 lyrs., pool of 11

D

Human

Blood

PeripheralBloodMononuclearCell

DA

Human

Placenta

26yrs„ 1 specimen

DB

Human

Prostate

Adult Prostate

DC

Human

Pineal Gland

Adult Pineal Gland

DD

Human

Testes

10-6 lyrs., pool of 11

DE

Human

Testes

Adult NCCIT TeratoCA

DF

Human

Brain

N/A

DG

Human

Placenta

26yrs., 1 specimen

DH

Human

Brain

19-23wks., M/F pool of 5

DI

Human

Testes

10-61yrs., pool of 11

DJ

Human

Placenta

26yrs., 1 specimen

DK

Human

Fetal Kidney2

Fetal Kidney

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DL

Human

Brain

N/A

DM

Human

Brain

N/A

DN

Human

Brain

19-23 wks., M/F pool of 5

DO

Human

Testes

10-61yrs., pool of 1 1

DP

Murine

Embryo

Fetal ES cell embryoid bodies

DO

Human

Placenta

26yrs., 1 specimen

DR

Human

SalivaryGland

N/A

DT

Human

Brain

N/A

DU

Human

Brain

19-23 wks., M/F pool of 5

DV

Human

Pineal Gland

Adult Pineal Gland

DW

Human

Brain

N/A

DX

Human

X X Ul Aldll

Testes

1 0-6 lyrs., pool of 1 1

DY

Human

Brain

N/A

DZ

Human

Testes

Adult NCC1T TeratoCA

E

Human

Blood

PeripheralBloodMononuclearCell

EA

Human

X A U 11 J. (4.11

Brain

1 9-23 wks M/F oool of 5

EB

Human

X .1U1114J.A1

Melanoma

X ▼ X \S XM. l l \J %, X

Adult Melanoma

EC

Human

Brain

N/A

ED

Human

X AU111C111

Placenta

X lUvvlllU

26vrs 1 snecimen

EE

Human

Testes

10-6 lyrs., pool of 1 1

EF

Human

Liver

Adult Liver

EG

Human

Pancreas

Adult HPC-3 Ductal AdenoCA

EH

Human

Blood

PerinheralBloodMononuclearCell

EI

Human

Brain

19-23wks., M/F pool of 5

EJ

Human

Placenta

26yrs., 1 specimen

EK

Human

Brain

19-23 wks., M/F pool of 5

EL

Human

Testes

10-6 lyrs., pool of 11

EM

Human

Fetal Kidney2

Fetal Kidney

EN

Human

Brain

19-23 wks., M/F pool of 5

EO

Human

Adrenal Gland

Adult Adrenal Gland

EP

Human

Placenta

26yrs., 1 specimen

EO

Human

Testes

10-6 lyrs., pool of 1 1

ER

Human

Brain

19-23wks„ M/F pool of 5

ES

Human

Placenta

26yrs., 1 specimen

ET

Human

Testes

10-6 lyrs., pool of 11

EU

Human

Kidney

Adult Kidney

EV

Human

Stomach

Adult Stomach

EW

Human

Placenta

26yrs., 1 specimen

EX

Human

Testes

10-61yrs., pool of 11

EY

Human

Brain

19-23wks., M/F pool of 5

EZ

Human

Fetal Kidney2

Fetal Kidney

FA

Human

Brain

19-23 wks., M/F pool of 5

FB

Human

Placenta

26yrs., 1 specimen

FC

Human

Testes

10-6 lyrs., pool of 11

FD

Human

SalivaryGland

N/A

FE

Human

Brain

N/A

FF

Human

Testes

Adult NCC1T TeratoCA

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SUBSTITUTE SHEET (RULE 26)

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FG

Human

Brain

FH

Human

Brain

FI

Human

Small Intest

FJ

Human

Lung CA

FK

Human

Kidney

FM

Human

Brain

FN

Human

Brain

FO

Human

Brain

FP

Human

Placenta

FQ

Human

Testes

FR

Human

Placenta

FS

Human

Testes

FT

Chicken

Fetal Lung

FU

Chicken

Limb Bud

FV

Human

Testes

FW

Human

Testes

FX

Human

Brain

FY

Human

Placenta

FZ

Human

Placenta

G

Human

Blood

GA

Human

Testes

GB

Human

Placenta

GC

Human

Testes

GD

Human

Placenta

GE

Human

Brain

GF

Human

Brain

GG

Human

Fetal Kidney2

GH

Human

Placenta

GI

Human

Retinoblastoma

GJ

Murine

Spleen

GK

Human

Fetal Kidney2

GL

Murine

Lymph Node

GM

Human

Uterus

GN

Human

Blood

GO

Human

Adrenal Gland

GP

Human

Ovary

GQ

Human .

Pineal Gland

GR

Human

Pancreas

GS

Human

Retina

GT

Human

Brain

GU

Human

Fetal Kidney2

GV

Rat

Retina

GW

Chicken

Limb Bud

GX

Human

Brain

GY

Human

Testes

GZ

Human

Brain

H

Human

Blood

N/A . .

19-23wks., M/F pool of 5
Adult Small Intestine
Adult Lung C A
Adult Kidney
N/A

19-23wks., M/F pool of 5
N/A

26yrs., 1 specimen
10-61yrs.,pool of 11
26yrs., 1 specimen
lO-Glyrs., pool of 11
Fetal Lung

Fetal St. 23 Limb Bud

Adult NCCIT TeratoCA

Adult NCCIT TeratoCA

19-23wks., M/F pool of 5

26yrs., 1 specimen

26yrs., 1 specimen

PeripheralBloodMononuclearCell

10-61yrs., pool of 11

26yrs., 1 specimen

10-61yrs., pool of 11

26yrs M 1 specimen

N/A

19-23wks„ M/F pool of 5

Fetal Kidney

26yrs., 1 specimen

Adult Retinoblastoma Y79

Adult Spleen

Fetal Kidney

Adult Lymph Node

N/A

PeripheralBloodMononuclearCell
Adult Adrenal Gland
PA-1 Teratocarcinoma
N/A

Adult HPC-3 Ductal AdenoCA

16-75yrs., pool of 76

N/A

Fetal Kidney
Newborn Retina
Fetal St.26 Limb Bud
N/A

10-61yrs., pool of 11
19-23wks., M/F pool of 5
PeripheralBloodMononuclearCell

90 . .

SUBSTITUTE SHEET (RULE 26)

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HA

Human

Testes

Adult NCCIT TeratoCA

HB

Human

Fetal Kidney2

Fetal Kidney

HC

Human

Brain

19-23wks., M/F pool of 5

HD

Human

Brain

N/A

HE

Human

Testes

10-61yrs., pool of 11

HF

Human

Brain

19-23wks. 7 M/F pool of 5

HG

Human

Fetal Kidney2

Fetal Kidney

HH

Human

Brain

N/A

HI

Human

Testes

10~61yrs„ pool of 11

HJ

Human

Brain

N/A

HK

Human

Brain

19-23wks., M/F pool of 5

HL

Human

Fetal Kidney2

Fetal Kidney

HM

Human

Testes

Adult NCCIT TeratoCA

HN

Human

Fetal Kidney2

Fetal Kidney

HO

Human

Brain

N/A

HP

Human

Brain

19-23wks„ M/F pool of 5

HQ

Human

Testes

10-61yrs., pool of 11

HR

Human

Brain

N/A

HS

Human

Brain

N/A

HT

Human

Brain

19-23wks. t M/F pool of 5

HU

Human

Fetal Kidney2

Fetal Kidney

HV

Human

Testes

10-6 lyrs., pool of 11

HW

Human

Brain

N/A

HX

Human

Brain Hippoca

Adult Brain Hippocampus

HY

Human

Trachea

Adult Trachea

HZ

Human

Brain Thalamus

Adult Brain Thalamus

I

Human

Blood

PeripheralBloodMononuclearCell

IA

Human

Thyroid

Adult Thyroid

IB

Human

Embryonal CA

Fetal NT2-D1

IC

Human

WERl-Rbl line

Adult Retinoblastoma

ID

Human

Muscle

N/A

IE

Human

Brain

1 9-23 wks., M/F pool of 5

IF

Human

Uterus

N/A

IG

Human

Testes

10-61yrs., pool of 11

m

Human

Muscle

N/A

n

Human

Brain

N/A

u

Human

Blood

PeripheralBloodMononuclearCell

IK

Human

Retinoblastoma

Adult Retinoblastoma Y79

JL

Human

Retina

l6-75yrs., pool of 76

EM

Human

Various

Various

IN

Human

Prostate

Adult Prostate

IO

Human

Brain

19-23wks., M/F pool of 5

IP

Human

Fetal Kidney2

Fetal Kidney

IQ

Human

Prostate

Adult Prostate

IR

Human

Brain Hippoca

Adult Brain Hippocampus

IS

Human

Trachea

Adult Trachea

IT

Human

Brain Thalamu

Adult Brain Thalamus

91

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SEQUENCE LISTING

(1) GENERAL INFORMATION:

(i) APPLICANT : Jacobs, Kenneth

McCoy, John
LaVallie, Edward
Racie, Lisa
Merberg, David
Treacy, Maurice
Spaulding, Vikki
Agostino, Michael

(ii) TITLE OF INVENTION: SECRETED, EXPRESSED SEQUENCE TAGS

(iii) NUMBER OF SEQUENCES : 1519

<iv) CORRESPONDENCE ADDRESS

(A) ADDRESSE: Genetics Institute, Inc.

(B) STREET: 87 CambridgePark Drive

(C) CITY: Cambridge

<D) STATE: Massachusetts

(E) COUNTRY: U.S. A

(F) ZIP: 02140

(v) COMPUTER READABLE FORM:

(A) MEDIUM TYPE: Floppy Disk

{B ) COMPUTER: IBM PC Compatible

(C) OPERATING SYSTEM: PC- DOS/MS -DOS

(D) SOFTWARE: Patentln Release #1.0, Version #1.30

(vi) CURRENT APPLICATION DATA:

(A) APPLICATION NUMBER:

(B) FILING DATE:
<C) CLASSIFICATION:

(vii) ATTORNEY/AGENT INFORMATION:

(A) NAME: Brown, Scott A.

{B) REGISTRATION NUMBER: 32,724

(ix) TELECOMMUNICATION INFORMATION:

(A) TELEPHONE: (617) 498-8224

(B) TELEFAX: (617) 876-5851

(2) INFORMATION FOR SEQ ID N0:1:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 4 00 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:l:

GGAGATGTTG AGGTGGCTGC TGACCTTGGG TCTCATCTCC TTGATTTTCT TTATCTTCTT 60

CATTGCCGTC CTCTCTAGGC TGTCTTTGGC GAGGAGGGCC CCTGCGGAAT CGTGGTCTAT 120

ATCCCCGATA CATATTCTGC CTCACTGGTC TACCTTGTTC TCCTGCACCC TGGTTGTCAG 180

CACCCTCCAT CACTTCTCCC TGCACAGGAG GGTTGGAATA CTGTGGTCGA CGCC CATAGG • 240

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GTCTCCGCAT GTAGTAAGGT GGGAACCTTC GCCTGCGGTA GGGCCGGCGT TGTTGGGCCT
GG CCTTCGGG AGCACTCTCC GATCCCTCGT TCTTTTCCCC ACTCTCACTA TTCTGGTAAT
TTTGCTGGTA ATTGCGTGGA GGAGAACAGG TAGACTCGAG

300
360
400

(2) INFORMATION FOR SEQ ID NO : 2 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 165 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2:

GAATTAGTTG CCAGCACTTT AAAAATTGGT ATAGTTCACA TAAATATTCT GAATTCAGGC 60
TTTTGGAAAA GTTGTGGACC CAAGAATACT AGGCCCGCAT TTTCTTACGT CAACATTCTT 120
TCCAGGATGA TGAATGGACT GTTCTCTTTG GCCCCCTATC TCGAG 165

(2) INFORMATION FOR SEQ ID NO: 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 99 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3:

GAATTCTAGA CCTTCCTCTC CTACTCCCTT CCTTAGG CTC CTGAACTCGT TTGCTCCTAA 6 0

ATCTTGTTAA TTCTTTTTCT CTGGATTTTG GTTTCTTTTG GCTTTCCCTT GCCTTCCCCT 120

TTCTCTGTCT CCAACACTCT TTCCCCATGT CTTTCTGGCT GTCTCTATGT TCCTCTTCTC 180

TTATCCTCAA CTTTCTGTCC ATTCGGGCCT CCTCCCCACC TCCCACGCCC CAGCCCCTCC 24 0

CTCCTTGGTC TCCTTTTCGA TATGCCAAAC CAATTTTGGG TCGAG TGCAT TCCCTCGAG 29 9

(2) INFORMATION FOR SEQ ID NO: 4:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 241 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4:

GCGATTGAAT TCTAGAC CTG CCTGGATTGC CTTCTGTTGT GGTAGACAAA TCACCATTAA 6 0

ATGACTAAGT TTCACTGTTT TATGTGTTAA TGATCCTTAA TAACAAAAAG TTTTAAAGTC 12 0

TTAATTTCGT AAGATTATGT AAAGGTTAAG AAAGAAATTT TAAGTGAAAA TGATAAAACC 180

AAG CAAATGT TTATTAGTTC AATTGTTTTT CTTTTTATCT TGCAGCAACG CACATCTCGA 24 0

G 241

(2) INFORMATION FOR SEQ ID NO: 5:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 368 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 5 :

GAATTCGGCC TTCATGGCCT AGGAAATGAC TTTATTGTGG TTGAATTAGT TAAAGG GTAC 60

TTACATTACG TGTTTGATTT GGGAAATGGT GCTAACCTCA TCAAAGGAAG CTCAAATAAA 120

CCTCTCAATG ACAATCAGTG GCACAACGTG ATGATATCAA GGGACACCAG CAACCTCCAC 180

ACTGTAAAGA TTGACACAAA AATCACAACG CAAATCACCG CCGGAGCCAG GAACTTAGAC 24 0

CTCAAGAGTG ACTTATATAT AGGAGGAGTA G C T AAAG AAA CATACAAATC CTTACCAAAA 3 00

CTTGTACATG CCAAAGAAGG CTTTCAAGGC TGCCTGGCAT CAGTTGATTT AAATGGACGG 360

CTCTCGAG 368

(2) INFORMATION FOR SEQ ID NO : 6 :

(i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 430 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 :

(2) INFORMATION FOR SEQ ID NO : 7 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 391 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7:

GGGTGGCTCA TGCCTGTAAT CCCGGCACTT GGGTAGGCCA GGGCAGCAGG ATCG CTTGAG 60

CCCGGGAGTT CGAGACAGCC TGGGCAACAT GGTGAGACCC TGTCTCCATA AAATTTTTTA 120

AAAAATTGCC AGGTGTGGTC GTGTGTGCCT GTGAGGCTGA GGTGGGAGGC TCGCTTGAGC 180

CCAGGGGTCA AGGCTGCAGT GAGCCATGAC TGCACGCCAC TGCACTCCAG CGTGGGTGAC 240

AGAGTGAGAT ACTGTATAAA AAAAAAAAGC TAAAACAAAA CAAGAAGTAT TAT CTTAAG C 3 00

ATGTTATTTA GAAATATGGA GATAAATAAA AATAACTGAA AGTAGGTCGT TGCTTCTGAG 3 60

GAGAGAAATT GGGAGTTGGC AAGGTCTCGA G 3 91

(2) INFORMATION FOR SEQ ID NO: 8:

GAATTCGGCC TTCATGGCCT ATAAAATTTA

CAAAGCTTTC ACAGAGCTCC TCTTAGACAT

GAGGTGTGGG CAGGACTGCC CTTCCTCCGT

TGAAAGTATG TAAATCTGAT GGGAGGTCTG

GGTGGAGTCT GGCTGATGGC CAGGGCCATG

GCTCTAAAGG GAGTGGTGTC CCTTTAGGCC
G CAGGACTCA GGGCCTGGGG GTGGCATCAG
CTGTCTCGAG

AAAATGC TAA GGATCTGGCC CCACAGGCCC
GAAGATGCCC ATTGGCCTCC TAGGTCCCAG
TCTCATTGCG GGGCTCCTGA AGGGGGTATC
ATCCTCCTTT TGCTAGCCCC TGAACTCTGT
TCCTAGAGGG GACTCCCCTG CAGGAGGCGG
AGGGTTCACA GTCGGGGTGG TCTGGAGACT
TCTGGCCAGG CCCTGCGTCA CTTGCACCCA

60
120
180
240
300
360
420
430

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 3 51 base pairs
<B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO : 8 :

GCTTTTGGAG CTGCTAAAAT GCCGGATTAC CTCGGTGCCG ATCAG CGGAA GACCAAAGAG 6 0

GATGAGAAGG ACGACAAGCC CATCCGAGCT CTGGATGAGG GGGATATTGC CTTGTTGAAA 12 0

ACTTATGGTC AGAGCACTTA CTCTAGGCAG ATCAAGCAAG TTGAAGATGA CATTCAGCAA 160

CTTCTCAAGA AAATTAATGA GCTCACTGGT ATTAAAGAAT CTGACACTGG CCTGGCCCCA 24 0

CCAGCACTCT GGGATTTGGC TGCAGATAAG CAGACACTCC AGAGTGAACA GCCTTTACAG 3 00

GTTGCCAGGT GTACAAAGAT AATCAATGCT GATTCGGAGG ACCCACTCGA G 3 51

(2> INFORMATION FOR SEQ ID NO : 9 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 354 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(XX) SEQUENCE DESCRIPTION : SEQ ID NO : 9 :

GTGATGTGTC ACCCCAAGTG CTCCACGTGC TTGCCAGCCA CCTGCGGCTT GCCTGCTGAA 60

TATGCCACAC ACTT CACCGA GGCCTTCTGC CGTGACAAAA TGAACTCCCC AGGTCTCCAG 12 0

ACCAAGGAGC CCAGCAGCAG CTTGCACCTG GAAGGGTGGA TGAAGGTGCC CAGGAATAAC 180

AAACGAGGAC AGCAAGGCTG GGACAGGAAG TACATTGTCC TGGAGGGATC AAAAGTCCTC 240

ATTTATGACA ATGAAGCCAG AG AAGC TGGA CAGAGGCCGG TGGAAGAATT TGAG CTGTGC 3 00

CTTCCCGACG GGGATGTATC TATTCATGGT GCCGTTGGTG CTTCCAAACT CGAG 3 54

(2) INFORMATION FOR SEQ ID NO: 10:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi.) SEQUENCE DESCRIPTION: SEQ ID NO: 10:

GAATTCGGCC TTCATGGNCT AGGAGGAGGA AGAGGAGTAC GAGGATGACG AGGGAGGAGG 60

GGGAAGACGA GGAGGAGGAG GAGGCTGCGG CAGAGGCTGC CGCGGGGGCC AAACATGACG 120

ATGCCCACGC CGAGATGCCT GATGACGCCA AGAAGTAAGG GGGGCAGAGA TGGATGAAGA 180

GAAAGCCCAC GAAGAAAAAA GCCTGGTTTT GTTTTTCCCA GAATATCGAT GGACTTAAAA 240

AGGCTCAGGT TTTTGACCAA AATACAATGT GAATTTATTC TGACATTCCT AAAATAGATT 3 00

AAATTAAAGC AATTAGATCC TGGCCAGCTC GATTCAAATT TGACTTTCAT TTTGAACATA 360

ATAAATATAT CAAAAGGTGT TAAAGAAAAC TGAATTAAAC CCAAAATTAT GTTTTCATGG 420

TCTCTCCTCG AG 432

(2) INFORMATION FOR SEQ ID NO: 11:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 87 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 11:

CTATTTTACA TGCCCACCAG CATTGTATGG GGCTTCTCAC TTGTCCACAT GCTTGCCTGT 6 0

GTCATATTTG ACTTAAAGCT TATTTTGACG GGAAACCAAT TTGTCCTTTT TTTGGAAAGG 12 0

GATGGCACCA CAGATGTGAC G CGG ACAATG CATTTTGGGA CCCCTACAGC CTACGAGAAG 18 0

GAATGCTTCA CATATGTCCT CAAGGGCCAC ATAGCTGTGA GTGCAGCCGT TTTCCCGACT 24 0

GGAACCAAAG GTCACCTTCT TGACT CCTTT GCCCGTTCAG CTTTATGGGA TTCAGGCCTA 3 00

GATTACTTGC ACGGGACTGG ACATGGTGTT GGGTCTTTTT TGAATGTCCA TGAAGGTCCT 360

TGCGGCATCA GTTACAAA\C ATTCTCTGAT GAGCCCTTGG AG G CAGGCAT G ATTGT CACT 420

GATGAGCCCG GGTACTATGA AGATGGGGCT TTTGGAATTC GCATTGAGAA TGTTGTCCTT 480

GTGGTTCCTG TGAAGACCAA GTATAATTTT AATAAC CGG G GAAGCCTGAC CTTTGAACCT 540

CTAACATTGG TTCCAATTCA GACCAAAATG ATAGATGTGG ATTCTCTTAC AGACAAAGAG 600

TGCGACTGGC TCAACAATTA CCACCTGACC TGCAGGGATG TGATTGGGAA GGAATTGCAG 660

AAACAGGGCC GCCAGGAAGC TCTCGAG ' 687

(2) INFORMATION FOR SEQ ID NO: 12:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 420 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12:

GAATTCGGCC TTCATGGCCT AGTCGGTGGG TGCCTGTAGT CCCAGCTACT TGGGAGGCTG 60

AGGGAGGAGA ACTGCTTGAA CCCGGGAGGC AGAGGTTGCA GTGAGCCGAG ATTGTGCCAC 120

TGTACTCCAG CCTGGGCCAC AAAGCAAGAA TCTGTCTCAA AAAAAAAAAA AAGAAAAGAA 180

AAGAATAAAT TTCTTTTCCC CTTGAAGAAG TTGATTTAGG CACAGACTCT GGACTCTGGA 240

TTTCCCACAA TGTCTTATCT AGTCAACTCA AGTATCTGGA CTACAATTTT CTTGAAAGCA 3 00

AAG CCCATAT ATTAATAATC TTTACTTGTA TATAAATATT CAATAAATCA TTAAGTAAAT 360

GTGTAGAAGA ATTTTATGCT CAATAAGATC CACCCGATCA TGCATTTGAA AATTCTCGAG 420

(2) INFORMATION FOR SEQ ID NO: 13:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 379 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:13:

GAATTCGGCC TTCATGGCCT AGCACATACT CTGCTTTTCT GTCAACATCC CATTTTGGGG 60

AAAGGAAAAG TCATATTTAT TCCTGCACCC CAGTTTTTTA ACTTGTTCTC CCAGTTGTCC 120

CCCTCTTCTC TGGGTGTAAG AAGGGAAATT GGAAAAAAAA TTATATATAT ATTCTCCTTT 18 0

TAATGGTGGG GGGCTACTGG AGAGGAGAGA CAGCAAGTCC ACCCTAACTT GTTACACAGC 240

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AC AT AC CAC A GGTTCTGGAA TTCTCATCTT CGAACCTAGA GAAATAGGTG CTATAAACAG 3 00

GGAATTAAGC AAAATG CTGG ATGCTATAGA TCTTTTAATT GTCTTAATTT TTTTTCTATT 3 60

ATTAAACAAC AGGCTCGAG 379

(2) INFORMATION FOR SEQ ID NO: 14:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 52 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION : SEQ ID NO:14:

GTTCATGGCC TACGGAAAGT CAGCATGGAT AACAGACTGA TGGAACTCTT TCCTGCCAAT 60

AAGCAAAGTG TTGAACACTT CACAAAATAT TTTACTGAGG CAGGCTTGAA AGAGCTTTCA 120

GAATATGTTC GGAATCAGCA AACCATCGGA GCTCGTAAGG AGCTCCAGAA AGAACTTCAA 180

GAACAGATGT CCCGTGGTGA TCCATTTAAG GATATAATTT TATATGTCTA GGAGGAGATG 240

AAAAAAAACA ACATCCCAGA GCCAGTTGTC ATCGGAATAG TCTGGTCAAG TGTAATGAGC 3 00

ACTGTGGAAT GGAACAAAAA AGAGGAGCTT GTAGCAGAGC AAGCCATCAA G C ACTTG AAG 3 60

CAATACAGCC CTCT ACTTG C TGCCTTTACT ACTCAAGGTC AGTCTGAGCT GACTCTGTTA 4 20

CTGAAGATTC AGGAGTATTG CTATGACAAC ATTCATTTCA TGAAAGC CTT C CAGAAAAT A 4 80

GTGGTGCTTT TTTATAAAGC TGAAGTCCTG AGCGAGGATG CCCTCGAG 528

(2) INFORMATION FOR SEQ ID NO: 15:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 466 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15:

GAATTCGGCC TTCATGGCCT AGCCCAGGCC ACGCTACACT CTGCCCACAC TGGTGAGCAG 60

GAGGTCTTCC CACGCCCTGT CATTAGGCTG CATTTACTCT TGCTAAATAA AAGTGGGAGT 120

GGGGCGTGCG CGTTATCCAT GTATTG CCTT TCAGCTCTAG ATCCCCCTCC CCTGCCTGCT 180

CTGCAGTCGT GGGTGGGGCC CGTGCGCCGT TTCTCCTTGG TAGCGTGCAC GGTGTTGAAC 240

TGGGACACTG GGGAGAAAGG GGCTTTCATG TCGTTTCCTT CCTGCTCCTG CTGCACAGCT 3 00

GCCAGGAGTG CTCTGCCTGG AGTCTG CAGA CCTCAGAGAG GTCCCAGCAC TGGCTGTGGC 3 60

CTTTCAGGTG TAGG CAGGTG GGCTCTGCTT CCCGATTCCC TGTGAGCGCC CACCCTCTCG 4 20

AAAGAATTTT CTGCTTGCCC TGTGACTGTG CAGACTCTGG CTCGAG 4 66

(2) INFORMATION FOR SEQ ID NO: 16:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 2 88 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16:

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GAATTCGGCC TTCATGGCCT AGCGTGATCC TGGAACGTGC TCTAGTTCGA GAGAGTGAGG 6 0

GCTTTGAGGA GCATGTACCA TCTGATAACT CTTGAAGATA CAGAGAGAAA TCCATCTTTT 12 0

CCCAGGTCTC CTTCACTGAA AACAAAAATC TACTTACATA CACTGTCACC TTAGCATCAG 180

AGTCGGATTA ATGAACTGCG GAACAAGAGG TTGTGAGAAT CTAAGATGGA ACCTTTCTTT 24 0

CTTTCTTTCT TTTTTTTTAA ATTTTG TAT T TTCCATCCAA CACTCGAG 28 8

(2) INFORMATION FOR SEQ ID NO:17 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 4 84 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17:

GAATTCGGCC
CGGTAAAAAC
TATACTAAGC
CATACTGATG
GATGTTTTCA
CTCCTTTGGG
AGTTTATTGG
TATTCATCAC
CGAG

TTCATGGCCT
ACCAGTTTAG
ATTCCTTGGG
GGCCTTTTAA
TTGGATACCA
CAGTGGTCGA
GTGCTTATGT
ATTAATGACA

AGGGCTCTGC
TAACCATTTT
G CAT AAAACA
CACT TTATTG
CTACCTGGGA
GTCTCCTCTT
CAAATTTTCT
CAGACACTAT

TTATAAACTT
TATGATTTGG
GGCTGGATTT
CTGCTACAGA
ATATC CAGAT
CTCCTTGGTG
TTTTAATACT
ACTGAGTACC

CAAAGTTACA
AATACCATGA
ACTACTGGAA
GTAGTGAAAT
GTCTGCAGAC
TCTCTCATTG
GGAAAGTTTA
AATAATAGCA

CTGAAGGATA
TGGGAACATC
TGTGTGTCAT
CACGGACTAT
ATT AT TTCGG
GAG C AATGAT
TTTTTAATTT
ACCCTGGTCT

60
120
180
240
300
360
420
480
484

(2) INFORMATION FOR SEQ ID NO: 18:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 519 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 18:

GAATTGGCCT
GCGCACCAGC
CTAAAACTTA
ATCGCTAATG
AATGATGACA
ACCGTACGAG
AAGCCATCGC
TTGCTAACGA
AGGATGCTGT

TCATGGCCTA
GTGGCACATG
AAG TAT AT AT
AGGACACCAT
CCGTATAAGA
GCACGCTAAC
TAATGAGGAC
GGACGCTGTA
ATATGACATC

GGAGATATAC
TATACATATG
AAAAAAAAAA
ACAAGG CATC
CATCGCTAAT
AAGGATGCTG
ACTGTATATG
CACAACATCG
GCTAATAACA

CTAATGCTAG
TAACTAACCT
GACNTCGCTA
GCTAACGATG
TATGACGCTG
TACACAACAT
ACATTGCTAA
CTAATGACAC
CCGCTCGAG

ATGATGAGTT
GCACAATGTG
GTGAGCACGC
ACGCTGTACA
TATACGACAT
CG CTAATGAG
CGAGGACACT
CATATAAGAC

AGTGGGTGCA
CACATGTACC
TGTATACGAC
CAACAT CAC T
CGCTAATGAC
GACAGTGTAC
GTACAAGGCA
ATCACCAATG

60
120
180
240
300
360
420
480
519

(2) INFORMATION FOR SEQ ID NO: 19:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 342 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 19:

GCAGCTCTCA TCCTCGTCTC CCCAACACCA TAACGTCCTC ATCCCGCCTC CAACCCACAC 60

CAGGCCGAAG CCCTCAGAGA GTGTTTTCAT CAGGAACCAC TCTCGAACCT GAAGGTTGAC 120

TTTAGCGTTT AGCAACCCAG GGCGGTGTGT GTGTTTCCCG TTTTGTTTTC TGAGTGGTAG 180

CAGTGATCAC CGTAATTCCA TGTAGCCATG TGCTAGCAGA ACCCCTGTGT CCTCACCGTG 240

GCCCGTGTGA CCCCAGCCGA CGAGTGCCCG GCGGAGTCCC CGCTGCCTTC CCATGGTCCA 3 00

GTGAGCTGCC AGGGCATCAC ATGACTCTCA GCTGGGCTCG AG 342

(2) INFORMATION FOR SEQ ID NO:20:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 580 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 20:

GAATTCGGCC TTCATGGCCT AGAGCAGCTC TGAGGTAGAA ATTACAACGA TGAAAAGAGC 6 0

ACAACGTACA AAACCAAGAA AGAGTCTGTT GTGTGAAGGG TCATTCGATG AAGAAGCTTC 120

TGCACAGTCC TTTCAGGAAG TGTTAAGTCA ATGGAGAACC GGAAATCATG ATGACAACAA 180

GAAACAGAAT TTACATGCAG CAGTAAAAGA CTCATTGGAA GAATG CGAAG TACAGACTAA 240

TCTGAAAATT TGGAGAGAAC CACTTAATAT TGAACTTAAA GAAGACATTC TATCCTATAT 300

GGAAAAATTA TGGCTTAAAA AACACAGGAG AACTCCACAA GAGCAACTTT TTAAAATGCT 3 60

ACCAGATACG TTCCCACATC CACATGAAAC CACTGGTGAT GCACAGTGTT CTCAAAATGA 420

AAACGATGAA GATAGTGATG GTGAGGAGAC CAAAGTACAA CACACAGCTC TTTTATTGCC 480

AG TAGAAAC A TTAAACATAG AGAGACCTGA ACCATCTCTA AAGATAGTCG AACTGGATGA 540

TACTTATGAA GAGGAATTTG AAGAAGCAGA ACATCTCGAG 580

(2) INFORMATION FOR SEQ ID NO: 21:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 301 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 21:

GAATTCGGCC TTCATGGCCT AGAAAGATCT AATTATCATG GACCTGCGAC AGTTTCTTAT 60

GTGCCTGTCC CTGTGCACAG CCTTTGCCTT GAGCAAACCC ACAGAAAAGA AGGACCGTGT 120

ACATCATGAG CCTCAGCTCA GTGACAAGGT TCACAATGAT GCTCAGAGTT TTGATTATGA 180

CCATGATGCC TTCTTGGGTG CTGAAGAAGC AAAGACCTTT GATCAGTTGA CACCAGAAGA 24 0

GAG CAAGGAA AGGTTTGGAA AGATTGTAAG TAAAATAGAT GGCGACAAGG ATCGGCTCGA 3 00

G 301

(2) INFORMATION FOR SEQ ID NO: 22:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 332 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

99

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:

GAATTCGGCC TTCATGGCCT AAAAAAAGGA TGGTGTGTTG AGACCAGAAG CAGCAGCAGT 60

CCTCGACATC AACTACAACT TTCCTTCGCA C AGTG CAT AC CCTCTGATAT ACTGAACCCA 12 0

ACGCCTATCC TCCAGCCCCC TAAGAACTAG AGAGGGAGCC TCACAACATT CCAATTTAAT 180

C CTTCAGAAA ATTCATTACT CTTCAAAGTT GTCTGTGGTT TTGTGACAAC GATATGACTA 24 0

GGTG CAAAAT GGCTTGCAAC TAATTAACAA ACATAGAAGC ATCCAACAAA CATATACGTG 3 00

CACAAT CTG A GGATTTAGGG ATGAAGCTCG AG 332

(2) INFORMATION FOR SEQ ID NO: 23:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 23:

GAATTCGGCC TTCATGGCCT ACCAGCCTGG GCGACAGAGC AAGACTCAGT CTCAAAACAA 60

AACAAAACAA AACAAAAAGA GAAGG CTATT ATTAACATTC GAGATAATGT GCCAGACTGC 12 0

TTCCATGTAT TTTCATTATT CTGTCCCAAA TCTGGTGAAG TGGGTATCTG CACAGCTTTC 180

TCTAGATTGA ACAACTAGTA AGGGGGCTGG CCCTGGAGAA AGTTACCTCC TGCCTCGAG 23 9

(2) INFORMATION FOR SEQ ID NO: 24:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24:

GAATTCGGCC TTCATGGCCT ACTTTTATAT TGTTATTTTT G TAAAG CATC TTTTCTTCAA 60

TTCTTGTTGG CATTCTGGGC CAAAATATT T CAGGTTGGTT CGGTGTGGAG TTAAGAAAAG 120

CAGGCGTTTT AGTGGAGAAA TGGGGAACAG CATCAAGAAA GGCTTTTTTC CTTTTTTCTT 180

TTTTTTTTGG AGACAGAGTC TTGCCCTGTC ACCCAGGCTG GAGTGCAATG GTCTCGAG 23 8

(2) INFORMATION FOR SEQ ID NO:25:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 231 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 25:

GAATTCGGCC TTCATGGCCT AGATGGATTT CTTAATTGAA GTACTTTTAT AATCACAGTG 6 0

100

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ACTGAACAAA ATATTTTCAA AGACATTTGT CATTCCTTAA AGCCAAGATT TTAAAGACTA 120
ATGTCCTTCC TGAGGGTTAC TTTACTATAC TGTGTATGGT GTATAGCCAC AGAAAGTCAG 18 0

TCTGATAAAT TTTCAATGTG TAAGTGTGAT GCATTCAACC CAGATCTCGA G 231

(2) INFORMATION FOR SEQ ID NO: 26:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 07 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26:

GAATTCGGCC TTCATGGCCT ACACAGAGTA TATTTATAGC TAT CTCAGGG TCCTTGTCCA 6 0

ATTGTCTGTG TCATTTCTTC ATCTGCTTCT ACTGATTTTT TCTGCTTCTG TTTACTCTTC 120

ATTTTGGACC TATTTTCCCT TATTTGGTGC TTTGCATACA ATTTGTTGGG ACTGGATCTT 18 0

TGCTAGTCCT TTAAATGTTT TTAAGCTTTG TTTTGGGATG CAGTTAGGTG ACTCAGAAAC 24 0

AATCAGAAAC AATTTGATCC TTTTATGTCT CTTAAGCTTT GTTATAGGCA GGACCAGAGC 30 0

TCTCGAG 307

(2) INFORMATION FOR SEQ ID NO: 27:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 53 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 27:

GAATTCGGCC TTCATGGCCT ACAATAATAG CCTCCCACCT GGTCTTCCTT CTTCAGTCTC 6 0

TTCAGTCTTT CCCAAAGCTC TTGAATCCTA CATGAACCCA TGCCTCGGTC AAAATATTAC 120

AGGCTGCAGC CAATCTTCAA GTGGCATACA GGCCAAACAT CCATTTATAA TATGGTTGGA 180

ATTCCTAACA CATTTTATCA TAGATCTAAT GCCATACAAT AGGTGGAGGT TAGATCCTCA 24 0

CGCAACTCTC GAG 253

(2) INFORMATION FOR SEQ ID NO: 28:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 254 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear .

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO;28:

GAATTCGGCC TTCATGGCCT ACAGAGAACT TGTGTTCCGG TTTATTGAAG TTCAGACACT 60

TCTCCTCGCT CCATTCTGTC CACATTTGTG TG AGCACAT C TGGACACTCC TGGGAAAGCC 120

TGACTCAATT ATGAATGCTT CATGGCCTGT GGCAGGTCCT GTTAATGAAG TTTTAATACA 180

CTCCTCACAG TATCTTATGG AAGTAACACA TGACCTTAGA CTACGACTCA AGAACTATAT 24 0

GATGCCAGCT CGAG 254

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(2) INFORMATION FOR SEQ ID NO: 29:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 211 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 29:

GAATTCGGCC TTCATGGCCT ACGAGAAGGA GTGGAAGAGT AAGCAGACTA GGAAAATACA 60

GTACAACCAT CAGGCAGCAT TACAGACCCA CTTAAGGTTT GTGGCCATGT GTGGTTGTGT 120

GGTTTTTTTT CTGGCCATGC TCAGTTACAT AGGGGCAAGT GCAAAAAAAA CCCCAGAGTT 180

TGTTTTAACT AGAGCTCTGG TTTTGCCAAA C 211

(2) INFORMATION FOR SEQ ID NO: 30:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 521 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 30:

GAATTCGGCC TTCATGGCCT AGGATCAGGT TCGTCCTTTA GTGTTGTGTA TGGTTATCAT 60

TTGTTTTGAG GTTAGTTTGA TTAGTCATTG TTGGGTGGTG ATTAGTCGGT TGTTGATGAG 120

ATATTTGGAG GTGGGGATCA ATATAGGGGG AAATAGAATG AT CAG TACTG CGGCGGGTAG 180

GCCTAGGATT GTGGGGGCAA TGAATGAAGC GAACAGATTT TCGTTCATTT TGGTTCTCAG 24 0

GGTTTGTTAT AATTTTTTAT TTTTATGGGC TTTGGTGAGG GAAGTAGGTG GTGGAGCACA 3 00

GGCACTG CAG GTCAATGGAG GTGGAGTACA GGGACTACAG GTCAATGGAG GTGGAGCACA 360

GGGACTAAAG GTCAATGGAG GTGGGGCACA GGGACTACAC GTCAGTGGAG GTGGAGTCAC 420

AGGGACTACA GGTCACTGGA GGTGGAGCAC AGAGACTACA GGTCAGTGGA GGTGGGGCAC 4 80

AGAGACTACA GGTCAGTGGA GGTGGAGCAC AGAGACCACA G 521

(2) INFORMATION FOR SEQ ID NO: 31:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 23 8 base pairs

{B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:31:

GAATTCGGCC TTCATGGCCT AAAATTTCCT CTAAGTACTG ATTTAGCTGC ATTGTATAAG 60

TATATGCTTC CATTTTCATT CATTTCCAAA TATTTTCTAA TTTCCTTTGC AATTTTTTTT 120

T CAGGAATTC GGGCCTTGCT GTGTTGCCCA GGCTGGAGAG CAGTGCCACT ATCACAGCTC 180

ACTATAAACT CAAACTCCTG GGCTCAAGCA ACCCTCCCAC CTCCCAACTC CCCTCGAC 23 8

(2) INFORMATION FOR SEQ ID NO: 32:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 257 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION ; SEQ ID NO: 32:

GGTTTCTTAA AAAAAAAAAA AAAAGGAATT TGATCCAGAG CAATTTTTCT CAATTAAAAT 6 0

TTGTGATTAC ATTTCTGAGT TTCCATGGCA GAGTTGTGAG TGGGGCTGTG ATATAATTTA 120

ACTTCTCCTA AATTGCTGAC AC CGATAACC CTATAAATTA ACAGATGGCG GAGGGAAATC 180

TCCTGGCTTC TTCCTGGCTA GTTTTTTTTA ATGGTCTGAT TTTTGTAATA GGGGTTTTGA 240

GTCCCAGCCG ACTCGAG 257

(2) INFORMATION FOR SEQ ID NO: 33:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 251 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 33:

GAATTCGGCC TTCATGGCCT AAAGACTTAC GTTATATTTT CATATACTCC TTCCCACTCT 60

TAGTGTGTTG TCAATATACA TTTTGTTTTA CATGTAAAAA CACCACAGTA TATTGTTCTT 120

AATTTTGCTT TTAATAGTAA ACTGTCTTAT AACAAATTAT GAAAATGGAA AAAAACATGT 18 0

CTTTCTTATT TGCCCTCATA TTTATCCATT TAGGCACTCT TCCTTTTTCC CTTTCATTCC 24 0

AGGTTCTCGA G 251

{2) INFORMATION FOR SEQ ID NO: 34:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 245 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:34:

GAATTCGGCC TTCATGGCCT ACTAACATTT ATGAAAATTA TTTGTAAATA AAATAAGAGG 60

CATTGAGATT AAAATTGGAG ATAAAGTTGC TGATGTGTTG TTTTCCTGAA GTATTTTTTT 120

TCTTAATTCT GATCTTTGTT TCCCAATACA ATCACACTCA CACCCTTGCA GTTCAGTTTC 180

CTGACGACTC TCTAGTGTGC CAGATCTGTG TTTCTATGTC AGTGATCTGT TCCCCATCTC 24 0

TCGAG 245

(2) INFORMATION FOR SEQ ID NO: 35:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 83 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D> TOPOLOGY: linear

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<ii) MOLECULE TYPE; CDNA

(xi) SEQUENCE DESCRIPTION;

SEQ ID NO; 35:

GAATTCGCTT CATGGCCTAC CGAGAAATGG

GTTTCATCAA GTGTGTGGAT CGTGATGTTC

ATGGGAACCA GCTCCATATT G C AG ATGAAG

CTGCTCAAAG AAATCATG CT ATTAGGATTA

ATTCCCATTC AGATCACCGT TTTCTGGGCA

CTAAAACCAC TAGCCCAAAT AAAGGCAAAG

ATGATGACTG TGGGGGTCTC GAG

GTGTGATTGC TGCCATGAGA GATGGTTTTG
GTATGTTCTT CCACTTCAGT GAAATTCTGG
TAG AG TTTAC TGTGGTTCCT GATATGCTCT
AAAAACTTCC CAAGGGCACG GTTTCATTTC
CGG TAG AAAA AGAAGCCACT TTTTCCAATC
AGAAGGAGGC TGAGGATGGC ATTATTGCTT

60
120
180
240
300
360
383

(2) INFORMATION FOR SEQ ID NO: 36:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 133 base pairs

(B) T"PE : nucleic acid

(C) STRANDEDNESS : double
<D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:36:

GAATTCGGCC TTCATGGCCT ACTGCCGCTC CTGGTGCTGC TTGTGTGCTC GTTTGGTGCG 6 0

GACCTGGTAC CTCTTTTGTG AAGCGGCAGC TGAGGAGACT CCGGCGCTCG CCATGGCCGA 120
CGAAAAGCTC GAG 133

(2) INFORMATION FOR SEQ ID NO: 37:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 37:

GAATTCGGCC TTCATGGCCT AAGGTAGT CT AGGCTCATCT TCATGAGGGA ACTGAGGTCT 60

TGGGGGGTGG GGGTTACCCA AATAGGTTCA CAGAAGAACC AGAAATAAAA CCTGCCTTTC 120

TAGACTGTAA GTCTTGTGAT TGTCATCTAA ATGGTTGTCT CTATACAGCA ACTCATCTCT 180

AGAAC TGAAA ATAAGTT TAA ATCCCTCCTC CATCCCCAAT AATTCAAGCT GCATTTCAGA 24 0

GAAAACCAGG ACTTTGGAAT CAGACAGCAA CTCGAG 276

(2) INFORMATION FOR SEQ ID NO: 38:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 36 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:38:

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GAATTTGTGC TCTTAGAGTA GGAGTTGGAA CTATAGGACT TGAAGGCAAG AGCAGGTATC 6 0

TTATCAAGGA TCTACTCACT CAGTTTCCCT AAAGCTCTCT CTCCAGATCG GATTCAACCG 120

CACATCATGA CAGATGTTCC GGCTACATTT ACCCAGGCTG AGTGTAATGG GGATAAACCA 180

CCTGAAAACG GTCAACAAAC AATCACTAAA AT CAGTG AGG AATTGACTGA TGTGGACAGC 24 0

CCCCTGCCAC ACTACAGGGT AG AAC C CAGT CTGGAAGGTG CACTCACCAA AGGAAGTCAG 3 00

GAGGAAAGAA GAAAATTACA AGGGAACAGA CTCGAG 33 6

(2) INFORMATION FOR SEQ ID NO: 39:

(ij SEQUENCE CHARACTERISTICS:

(A) LENGTH; 385 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 39:

GAATTCGGCC TTCATGGCCT AGTCGGAGAA GGACATCCAG GATCTGAAGT TTGGGGTCGA 60

GCAGGATGTT GATATGGTGT TTGCGTCATT CATCCGCAAG GCATCTGATG TCCATGAAGT 12 0

TAGGAAGGTC C TGGG AG AG A AGGGAAAGAA CATCAAGATT ATCAGCAAAA TCGAGAATCA 18 0

TGAGGGGGTT CGGAGGTTTG ATGAAATCCT GGAGGCCAGT GATGGGATCA TGGTGGCTCG 240

TGGTGATCTA GG CATTG AG A TTCCTGCAGA GAAGGTCTTC CTTGCTCAGA AGATGATGAT 300

TGGACGGTGC AAC CG AGCTG GGAAGC CTGT CATCTGTGCT ACTCAGATGC TGGAGAGCAT 360

GATCAAGAAG CCCCGCCCCA CTCGA 3 85

12) INFORMATION FOR SEQ ID NO: 40:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 245 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 40:

GAATTCGGCC TTGCTAAAAA AAAAAAAAAA GAGGCAAGTA ATGTAATATC CCCCACCTTT 60

GGTTTTCTTA TCTATAAATA CTGATTAAAA AAAAAAGTAC ACTGTCTGCC TTATAAGCTA 120

AAATGAGTGA ATACAGGCAA AATG CCTTAC ATTTTACTTT ACATTTACTA AGCACCCAGA 180

AAATGTTAAC TATGATGACA ATTATGATGA TGATGATATT GATATTTTCA AGGAGGGCGC 24 0

TCGAG 24 5

(2) INFORMATION FOR SEQ ID NO: 41:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 41:

GAATTCGGCC TTCATGGCCT AAATAAAGAT GATTTTTGTG CTTAGCAGTT TAAGGTATAT 6 0

GGCTGCATAT GCAAAACTCT TTCCCAATTC AGTCGCTACT TTTACTTCTG CCCTTTCTAT 12 0

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CCATCGTCTT CATTTTGTGT GTACAGTGCT GTGTGTAAGC TTATCAGTGT GTTTTTTTAT 180
TTGTATCAGT CATGAAAGTC CTGTTAGGTA TCCAGAGTTC TATTTATCTA GCTGTACAGA 24 0

TCTCGAG .24 7

(2) INFORMATION FOR SEQ ID NO: 42:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 106 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 42:

GGATATGGTA ACTGAGAACC ATTTTCTAGT TGAGATAACT CATGTACAGG GGGGGTCACA 60
TG ACT C AAC A ACACACAGAG CACAGAAGAG AACCAACAAT CTCGAG 106

(2) INFORMATION FOR SEQ ID NO:43:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 237 base pairs

<B) TYPE: nucleic acid

<C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:43:

GCGTATTTCC AAGTGTATGT ATTT CTAAAG ATAGATTTTT TAAAAACAAA AAATCTTAAT 60

TTAGATGATA AGCGATTTTT ACCTTTTTTT TTTTTTCAAA GCAACTTGAT CCTGTAAGTT 120

TTGGCATCTT AAGTGGAAAT GTT CATGCAG TTTTGCTGGA TCTTCGCTAT GGCAGTAAAA 180

TGCAATACAG CACTGTGGTT AAGAGTGCAG AACGGAGTCA GTCAGCCTGA ACTCGAG 23 7

(2) INFORMATION FOR SEQ ID NO:44:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 76 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 44:

GAATTCGGCC TTCATGGCCT ATAGGCCATG AAGGCCGGCC TTCATGGCCT AGGGAGTNGG 60

TGTGTCTGTG CATTTATTTG GATCATGGAA GGTTGTAGAT GTGTATTTCT AACTGTAGAT 120

AATGGAGGAC ACATATTTGG GGAGTTTTGA GAGGATGTGT ATGTGTGTGT GTGTGCAGTG 180

TGGTATTTCT CTATGTTTTG GTGGGTGGGG TATGTATCCA TCAAAATATC TCAGATTATC 24 0

TGATGTAAGA AAATAATTCT G CAT C TCAGT GACTT CCAAC AAGGTAGGTT TCTCATGTAT 300

GTTATGTGTC CTCCATTGGT TGGCTTTGAT CAGTTACTGG TCCTGTGCCT TGGATCCAGA 36 0

TGGATGAAGC GGCCTCATTT GGGACAGGAC TAGAAGGACT TCTTCTGCTC AGAGTCATAC 420

ATGGCATTTC TGATCACATT TCATTTGCCA TAACAAGTCA TGTGGCCATA CTCGAG 476

(2) INFORMATION FOR SEQ ID NO: 45:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 358 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 45:

GAATTCGGCC TTCATGGCCT AGGCAAACTC TGCTGGACTT AACTTCATCA ATGTAGTGGG 60

CTCTGTTTGT GGGGCCCAGG CTTTGATGAG TGGTTCAAAC CCCATGCTGG G CTGTAACAC 120

TGGTGCCATA ACTCCTGCAG GAATAAACCT GAGCGGCCTT CTACCCTCAG GAGGTCTGCT 18 0

ACCAAATGCA CTGCCCAGTG CAATGCAGGC AGCTTCTCAA GCAGGTGTTC CATTTGGTTT 24 0

AAAAAATACT TCAAGTCTCA GGCCCTTAAA TCTACTCCAG CTTCCAGGTG GTT CACTTAT 300

TTTTAACACT CTGCAGCAGC AG CAACAG CA GCTCTCCCAG TTTACACCAC AACTCGAG 3 58

(2) INFORMATION FOR SEQ ID NO: 46:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 53 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:46:

GAATTCGGCC TTCATGGCCT AATCATTTTG ACTTTCAGTG CTTTCAATGA CCAGTGGCCT 60

CCAGGGATAA AGCAACTGCT TGGTTTGCAG GGCGTCCTCT GCGCTGCTGA GCCATCAGCC 120

TCCAATACGC CAATGCCCAT AGATGCTAGT TACAGCCCTG CTTCCTCCTA CATAGGGTTC 180

TGTCATCACT GAGT CTCACC ATTTCCCTCT CCCCAGTGTC TTTATTATGT GACACACACA 240

CACGGCACTA TGTTTAAAAA AGCGTGCTCA CTGGCAACCT CTTGGCGTTG TGTGTTCATT 3 00

CTGTGTTTTG TATTGGTGGT ATCTTGGGGT CGACCGAAAG AGTCAACCTC GAG 3 53

(2) INFORMATION FOR SEQ ID NO: 47:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 56 base pairs

(B) . TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 47:

GAATTCGGCC TTCATGGCCT AGGGAGCTAC CAGATGCTGA AGAAAGGGCC CTGGCAGACT 60

GGGTTCAAAC TCAGCCATTG TCAGCTTGGT AACCTTGACC AAGTGTCTTC CC CTCTGTG A 120

GCCTCAGTTT TCTCAATAGT AAGAGGGGAT AACACACTTA CCTCTCATAG CTGTGGACAT 180

GGAGGTGAAA GTGCCGCATA CACTGTAAAG TGTTATATAC GTGTAAGAGA AAAAATCGGG 24 0

CCAGAGG CTG GGCTTGTGTT AATTG ATT CA GGAAATTCAC CAGAGGCCCC CTAGATGCAA 300

CGTCCTTTGG GTGTCTGGCA GTGGGCACAA AGATGAACAA AACAGTG CCC CACCCTCACC 360

CCGTCAACCG TCAGTGCAGC AGTGGGCTGG GTGCTTGCGT CCCACAGTGA GGAAGG CAGA 420

AGGGGTCCCT GCCCTCAAAG GAGGACGATA CTCGAG 456

(2) INFORMATION FOR SEQ ID NO:4B:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 509 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 48:

GAATTCGGCC TTCATGGCCT AGCTGCCCCG CAGCACTTAC CGGAGCGACC ATGAGGGTGA 60

CGATTTGAAG CACACACAGG CTTCCCGCCA CCTCCTTTAA ACCGCCGCTG GCTTGCCAGG 120

GACAGACGGC GCGGTTGGCT CCCCAAAATT CCGACTGATA CGCGCCTCGG CGAGCGAAAG 180

CAAACG CGGG ATACTCTCGC GTTCCTGATT GGCTGCAGTT GGAATTGATC ACACCTTTTC 24 0

AGTTGTACTT CAATCCTGAA TTAATCTTTA AACACTTTCA AATATGGAGA TTAAT CACCA 3 00

ACTTCTTATT TTTTGGGCCA GTTGGATTCA ATTTTTTATT TAACATGATT TTTCTATATC 3 60

GTTACTGTCG AATGCTAGAA GAAGGCTCTT TCCGAGGTCG GACAGCAGAC TTTGTATTTA 4 20

TGTTCCTTTT TGGTGGATTC TTAATGACCC TTTTTGGTCT GTTTGTGAGC TTAGTTTTCT 4 80

TGGGCCAGGC CTTTACAATA ATGCTCGAG 509

(2) INFORMATION FOR SEQ ID NO: 49:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 467 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 49:

GAATTCGGCC TTCATGGCCT AAAGCAAGTG ATTTTCTTTT TTTTAAAGAC AGGGTCTCAC 60

TTGGTCACCC AGGCTGGAGT ACAGTGACAT CATCACGGCT CACTGCAACC TTCGCCTCTT 120

GGGCTCAAGT GATTCCCCCA TCCCCCACCC CCCTTCTCAC CCCCAGATTG GACTATAGGC 1B0

GTGTACCACC ACGCCTGGCA GAG AC CGGGT TTTGCCGTTG CCCAAGCTGA TCTCGAACTC 24 0

CTGAGCTCAA GCGATCTGCC CGTCTCAGCC TCCCCTAAGC AAG CATTTTT AAGTTTCTAT 3 00

G CTGTTTAAT TTTTTTTAAC TGATTAATTT ATTTGCATTG TGTGGTCATG GAATATGTTT 360

TTATGATATT GGTTGTTTGA GATTTGGTGA GTCTTTCTTT GTAAC CTAGT TAAACCATTC 420

CATATCTTTT TAAAAGGATG TATATTCCTT ATCTGTTAGG GCTCGAG 4 67

(2) INFORMATION FOR SEQ ID NO: 50:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 168 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 50;

GAATTCGGCC TTCATGGCAG AGTGGAAGGG GTTGTAAATA TTAGGAGAGA GATAATTCTT 6 0

AGTGCATTTC TCTGAGGATG AAGCATGAGA TGAATCCATG GCACGAATGG AACAGCTGGG 120

GAAAG CAGGT CAGAATGGAT ATGGATATAA ATACTGTGAG TTCTCGAG 168

(2) INFORMATION FOR SEQ ID NO: 51:

108

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 228 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 51:

GAAGTAAATT ATTACGATTT CCTTAGGTGG TTAATAAATT ACCATTATTT TCTCTATTTT
ACAGATCACG AAATGATAAG TAACTTACCG AAAGTTACAT TATTTAAGTT AATCAAATGT
TTATTGATTG CCAGACTTTT TTCTAGGCTT AAGCAAATGT TGGAAAATAC TTCTCTGAGC
TTTCAAAAAT GTTATTTCTA CTTGTCAGTG CTG CAGGAG T CTCTCGAG

(2) INFORMATION FOR SEQ ID NO: 52:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 247 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO:52:

GCAGAGTCAA TAGATACTTT AAATTGAAGT AAAGAATTAA AAAAGGAAGT GGATAGTTTG
GGTATTAGTT TAGCTAGAAA TACAAAGAAA CTTGACTTCT AGGGCAGTAC AAATTCAAGC
CTTCCACAAA CAAACAGTTG AGAGTATGTT TATCTTCTTA AAATGTGTGG GTGCCTTCCC
ACCACTTCAC CTGCTCCTCA CTGGTGCTTT GTCCCCTCCC TACTACCATT CCTGTCCCGG
TCTCGAG

(2) INFORMATION FOR SEQ ID NO : 53 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:53:

GGCCAAAACA AAGCTTATAA AGGTTCCTGC TCCCAACGTA ATTACCTCCA ATCGG CATTT
AAAGACATCC GCATTGCTTA CAGCACATCC TAGCCTCATG CTTGCCCAAG GATGGACTCG
AAATGAACTA TTTCCAGAGC GACTTATTCA GGCATTCTGT GGAGCCTCCG TTGCCCTGTC
CATCACCGGA GCTTTTGTAA TTGCAGCTAT GCCATTGGCC TCCGGCAACC TCGAG

(2) INFORMATION FOR SEQ ID NO: 54:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 231 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

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<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54:

GAATTCGCCT TCGTGGCCTA AAAAGAAAAA ATCTAAGGTA GATTGTGCCT TTTGTGCCTT 6 0

TCCTCTGCTC AAGACCTTTC AGTGGCTTCC CACTTCACTC AGTAAAAGGC AAAAAGTCCT 120

TTTAATAACC TACAAGG CAT TATGTTACCC ACATTGTCCC TGCTCCCCTA CATTGTACTC 180

AAGTCTATGA TCTTTTTACC ATTCCTTGTA CAAAGGATTT TCACTGGCTG G 231

(2) INFORMATION FOR SEQ ID NO: 55:

Ci) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS ; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 55:

GAATTCGGCC TTCATGGCCT AGAAATATTT TCCTACAAGA GTACTGAATT TCAGGAAATG 60

GGATAG AG CT TCTAACCAGT GTATTCCGTC AAG TAAG AT A ATAACAG CTG ACCTGCCAAC 120

AGCATTACAG GGAGATTCTT TGCTCAGCTA ACACATTTCT GTTTTTCAAA ATTGATGCTT 180

AATTGTAGCT GTTATTCTAA TTTGTGACAT GGAACTAACT CATGCTTCAA TCCTTGATAG 24 0

AGCAAAACTC AGAACAGGTT ATGTAAAAAT ATAGTCTGGC TTTAGAATTT GTTAATTCAC 3 00

CTGCTTTGCC ACAGAAAATG GAGACTCGAG 3 30

(2) INFORMATION FOR SEQ ID NO: 56:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 0 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 56:

GAATTCTAGA CCTGCCTCGA GATCTGAACT ATAATCTTTT CCATTCTATC TAGCTCCCAT 6 0

CCTAAGTCCT CTCCTCCTAA CGTGGAACTC TCCTAAAATC TTCTCCTTAT ACTAGGGTTC 12 0

GAGACATGAG GCTGTCTTTT TGGGCCTTTT GCGTTGTCAC AGTCCCAGAC CACGGAACAT 180

TCTCTCTTCC CCAGGACAGG ACATTCTCTC TTCCCCAGCG CTCCCTCGAG 23 0

(2) INFORMATION FOR SEQ ID NO: 57:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 416 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 57:

GAATTCGGCC TTCATGGCCT AAAGGGAAAG TGGGAATATA CACAATGCAN ACACTAGCCA 60
CATG CAATCA TGGGAGAACA GAGCCTACTT AAAAATCANA CCCAAGCTTT GCTTCAGAAA 120
TAAGTGGAGT TGAACCCATT CGATCATTTA CGCATGACTT TGCAAAGGTT CTCTGGAGGG 180

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GGAAGAGGAT CAACCTTCTC TCATACCGCA CAGCAAGGGA ACCAAAGTAA TATAAAT CAC 24 0

TCTTAAAAAT G TCATGTT AC TTTAAGAATA AGCCATACTG CTGGCACCTA GAATATTTTT 3 00

GTGGGTCCCC ATCTCTGGCT TTTCTTGTTC AAATGGCCCC CAGGCTAAGA GGCAGCTGCT 360

CACATCCCTG CAACAAACAT GTTCTTTCCT TTCTGCATAG CCTTCCATTT CTGGAG 416

(2) INFORMATION FOR SEQ ID NO: 58:

U) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 2 89 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: SB:

GAATTCGGCT TCATGGCCTA CTAGACCTGC TCAGTCGTTC CTAATGAATA AAAATCAAGT 60

GCCAAAGCTT CAGCCCCAGA TAACTATGAT TCCTCCTAGT GCACAACCAC CACGCACTCA 120

AACACCACCT CTGGGACAGA CACCTCAGCT TGGTCTCAAA ACTAATCCAC CACTTATCCA 18 0

GGAAAAGCCT GCCAAGACCA GCAAAAAGCC ACCACCGTCA AAGGAAGAAC TCCTTAAACT 24 0

AACTGAAACT GTTGTGACTG AATAT CTAAA TAGTGGAAAG TCACTCGAG 28 9

(2) INFORMATION FOR SEQ ID NO: 59:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
CD) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 59:

GAATTCGGCC TTCATGGCCT AATTTGAGGC CTGGGTGGAA CTGACAGGTG GAGTTTGAAG 6 0

GCACATCTGC TAGCTCACAT AGGAAACAGA ATCTCCCAGG GAAAAGACAT AGGACCTCTG 120

ACTCTAACTG AGGTTCTGGA TTATTATGAG AGATTTTCAG AAATGGTCTA ATGGTGTTGG 180

CTTGCTCCAT ACCATAGATT TTAAGAGACA GTAGAGCTTC TGCGATGAGA TTCCCCCATA 24 0

AAATAATTAT GGATCTGCAC TGGCAAGCTG GTCTTGGCTC CAAAGACCAA GAGTTGGTTT 3 00

GTGGTGCTGA TTCTGAACCC TTGCGATGCA ACTGTCTGGT AGTAAAATGG CTTTGTATGG 360

TAAGAAAGCT TTAATCCTCG AG 3 82

(2) INFORMATION FOR SEQ ID NO: 60:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 196 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 60:

AAAAAAAAAC CAAACCCTAT TATTTCATTG ACAGATTGTC TTAGAGTTGA TAGCATTTAA 6 0

TAATTGAGTA AGTACAGTCC TTCCTTGTTC CCAACGTGCC CTATTTTTTC TTTCTTCTCT 12 0

ACTTTTGCAT ATGCATTTTC CCTCTTTCTT GTTTCTTGGT GAATTCCTAA ACCTTTTTTT 180

TCAAAATCAC CTCGAG 196

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(2) INFORMATION FOR SEQ ID NO: 61:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 81 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 61:

GAATTCGGCC TTCATGGCCT AACCACATTT TTCTAATTAG TGTTCTAGAC TGGCTAGATA 6 0

AATCAACAAT GAATCAACAG TCTTTAAGCA CATATACAGG TATGATAACT CTGTAGTTAA 12 0

CTCAAATCCT TGTGCTATGT ATTATTTTGC TGCGTAACTC AGAATTCAGG AAGCTACCCA 18 0

CCCAATCAGT CTTTAGCTGT TTTATTTCAG TAACAAGTTT ATGCAGAACC TTCCATATCT 24 0

CTCATAAAAC CAGAGCATTC ATAGAACCAG AAACTCTCGA G 281

(2) INFORMATION FOR SEQ ID NO: 62:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 400 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:62:

GAATTCGGCC TTCATGGCCT AAAAGATTTG AG CATTT CAA AATTTTAAAC ATAAAAGCAT 60

AAACGTAGAT AAAATGAAGG TGTACTATGA TATCTTCAGT TTT AT CAGAA ATGATGTAAA 120

AATTACAACC TCTTTAAAAA GTAGTGTTAA TCATTAAGTT AGAAAATATA TAG CTGGGCA 180

TGGTGGCAGA TGCCTGTAAT CCCAGCTACA TGGGAAGGTG AGGTGGGAGA ATCG CTTGAA 240

CCCAGGCAGT GGAGGATGCA GTGAGCCAAG ATCATGC CAC TGCACCCCAG CCTGGGTGAC 3 00

AGAACAAGAC TCCATNTCAA GGAAAAAAAA AAAGAAAAAT ATATATATGA ACTTCAGAAT 3 60

CTGAGGTCAT ATATAGACAG GTCTTCCCCC CGTCCTCGAG 4 00

(2) INFORMATION FOR SEQ ID NO: 63:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 297 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:63:

GAAACCATAG TGG CAGATTT GTAGCAAAAA GAATCTTTGT AACCTTCCCT TTAGATGTCC 6 0

TGTGTTATGG CTTGGTTTTT CTCAAAGATC ATAGATTGCA GTGTTTATCT CAACTCAGTA 120

TTTCCTTTGA AAATTGAACT TTTCTCTATA TTTTCCTTTC CCCCATGCAA ACTTTTTGAT 180

TGTTTTTCTG AAATCATAAT TCATTTGACT TACCAGTTAA TATTGATACA GGTCTTGCAT 240

GTTATGAAGT G CATTGTGT A CATTATC TTG TTTAATTTTC ACAACACTCT TCTCGAG 297

(2) INFORMATION FOR SEQ ID NO:64:

(i) SEQUENCE CHARACTERISTICS :

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(A) LENGTH: 361 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64:

GGTCGCAGAA GAGTGTCAGA ACAATCAGTT AAAGAAGCTC AAAGAAATCT GTGAGAAAGA 60

AAAGAAAGAA TTAAAGAAGA AAATGGATAA AAAGAGGCAG GAGAAGATAA CAGAAGCTAA 12 0

ATCCAAAGAC AAAAGTCAGA TGGAAGAGGA GAAGACAGAG ATGATCCGGT CATATATCCA 180

GGAAGTGGTG CAGTATATCA AGAGG CTAGA AGAAGCGCAA AGTAAACGGC AAGAAAAACT 24 0

CGTAGAGAAA CACAAGGAAA TACGTCAGCA GATCCTGGAT GAAAAGCCCA AGGGGGAAGG 3 00

TTCCTCCTCA TTCTTGTCGG AAACTTGCCA TGAGGATCCC TCTGTTTCCC CCAAACTCGA 360

G 361

(2) INFORMATION FOR SEQ ID NO: 65:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 93 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 65:

GAATTCGGCC TTCATGGCCT ACTGGGGGAA GAAGGCTGCT TTATGTTTAT TTTTCAAGAC 60

TTTAAAAATA TTTTTTGGTT GTATTGCACT AGGAAATCTC TCCCACCTCT CCCTTTTCTC 120

TTTCTTTCCC TATACAAAAT AAAAGGCCCA CCATAGAGAC TAGGCGGCCG AAAGACTAGG 180

AGGGCTGAGG AAAAGAAATA GGTCTCTGGA GGTGGAACTA AAACTGTGCA GCTGCCTCTT 240

CCTGGCGGTG GATGCTGCTT TGGGAGGGCC AGGGAGGCTG CAGGGGGACA GTGTTGGGAT 300

TGTCAAGGAA AAAGGGGTAG GAAGGAAGGT GGAGGGATTG ATCTAGTACC AGGGAGAATA 360

TTCCACTGAA CTGTGATTCT ATGCGGCCTC GAG 3 93

(2) INFORMATION FOR SEQ ID NO: 66:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 66:

GAATTCGGCC TTCATGGCCT AATTTGTTAT TGCTAGAAAA TACACAGTTT TGAGATTTTT 60

GGGCATAATT GGCCTTAGTG TGTCACTTCT G CAT T AAAAT ATAGGTTAAT AATCAGATGA 12 0

AAGCAGCCAA TAACCTATGG CTTCTGTACT TTCTGGTGAA AGTTTTGTTA ATGTTTTTAA 180

TTTGTATTTT TCTGCTTATA AATTTGTCCT TAAATCACTC CCCTCCTTCC CGCCCCCCCG 24 0

ACTCCTTCTC CCTCCTTCCC GCCCCCCCAA CTCCTTCTCC CTCCTTCCCG CCCCCGCGAC 300

TCCTTCTCCC TCCTTCCCGC CCCCCGATCC TCGAG 33 5

(2) INFORMATION FOR SEQ ID NO: 67:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 235 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 67:

GGTGACATAT TTATTGCTTC TGTTTTCCAA CTACATCACT TCAACTAGAA GTAAAGC TAT 6 0

GATTTTCCTG ACTTCACATA GGAGGCAAAT TTAGAGAAAG TTGTAAAGAT TTCTATGTTT 12 0

TGGGTTTTTT TTTTCCCTTT TTTTTTTTAA GAGTATAAGG TTTACACAAT CATTCTCATA 180

ATGTGACGCA AGCCAGCAAG GC CAAAAATG CTAGAGAAAA TAACGGGATC TCGAG 2 35

(2) INFORMATION FOR SEQ ID NO: 68:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 257 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 68:

GAATTCGGCC TTCATGGCCT ACCACAATCT GTTTGCTTTT CCTCTTTAGA TTCCAAAAAT 60

AACACCCCAA AGGCTACCTT TTCAAATATT CTACAACATC TGCAAAAATC TTTAGTACTC 120

TGTCCTTGGA GTCAGTCAAG AAATTCCACC CCAGAAGTGT AAAAACCAAT CAATAATATA 180

TGACACTGAT TTTCTCTAAA TTATTATTTT TCTTATGGTT GAGTCTCCTG CCAACTTTAT 24 0

GTTTCCCAAT CGGCTCG 257

(2) INFORMATION FOR SEQ ID NO: 69:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 261 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 69:

GAATTCGGCC TTCATGGCCT AGCTGGGCAT GGTGATGCAC GCCTGTAATT CTAGCTACTC 60

AGGTGGGGGG TTAAAGGTGA GGCAAGGTCA GCGGTGAAGT GCAG CTCAGA GGGAGGGGTC 120

AAACATAAAC CAGAACTTAT AGGTCTAGAG GTAAAATGGG ATTCATGGGG GGCAGAGGTC 1B0

AAAGG TGAAG CAGAAGTCAG GGGTGAAGGA AGGTCTGCAA AGTTAAAGGT GCGGTTTCCA 24 0

GAGTCAGAAG GGGTGCTCGA G 261

(2) INFORMATION FOR SEQ ID NO:70:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 279 base pairs

(B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 70:

GAATTCGGCC TTCATGGCCT AGATTGAATT TTTAACACAG TCCTCTCAGA AACTGACTAA 6 0

AACAGGTTTT AAAATTAGCA AATATTAAGA ACATACGAGT AAAAGTCAGT TTATTTTAGA 120

TAAGTAGGGA TTTAAATTCA ACAAAAATAA ACACATTTTA AACTCCTATA ATACATTTAT 180

TTAAAATAAA TATATTTTTG CCAAAAGAAG TGTAAGTTCA AAGAGTTAAC ATACAGATTA 24 0

TATCCTATGA GATATAATAA TATTAGAAAC TGGCTCGAG 27 9

(2) INFORMATION FOR SEQ ID NO: 71:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 55 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 71:

GAATTCGGCC TTCATGGCCT AGTTACATTT AT AAT CAGTG AGGAAAATAT AAACTATACA 60

ATAAATGAAA GGGTCATTGG CCAATTGTTT GGAGGGAAAA AATACACCAT GTTCTAAAAT 120

AAAT TTCTAG TGATTTATTG TGACTTTCAT GCATTTGGAT GATTTTAAAG ATTTTATATA 180

AAAATGAAAC CATAG CCTTA CGAGAAGAAA ATATAAAGAA AAACTTGTAT AGTCTTGGGA 240

GGGGGGATTC TCGAG 255

(2) INFORMATION FOR SEQ ID NO: 72:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 138 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 72:

GCGATTGAAT TCTAGACCTG CCTCGAGATC GTCTTTTCTA CCTGGATGAG AG CTCTACCA 60
CTTCTTTCCT TTTGCACACT CATCTCATTC TATGCACTCT TGGGCTGTAA CTGTCATTTC 120
TTTTCCTGTA CACTCGAG 138

(2) INFORMATION FOR SEQ ID NO: 73:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 208 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:73:

GAATTCGGCC TTCATGGCCT ATCACATTGC AT TAAATCTG TAGATTACAT TGAGCATTAT 60

GGACATCTTC AAAATATTTC AAATTTTGAA CAGGAGCATG CTGAAGAGTG TGTTGTTTAA 120

TTTCTATGTA TTTGTACATT TTTTTTCTCT AT CTTATACT GCCGAGACCA GCTCAGTCGG 180

GGAGACCCTA ACCCAACGGC AGCTCGAG 208

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(2) INFORMATION FOR SEQ ID NO: 74:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74:

GAATTCGGCC TTCATGGCCT ACATGAAACT GTTAGTCACT TCATTTCTGT TTCTTCCCTG 60

TTGCAACAGC CCATCTTCGT GGGAAGAACC AAGCTTTAGG CTTGGCTCTG AACAGCCACA 12 0

AAGTGACTTG GCTGAGGTCC TGCCATTTCG CTCATGCTCA GCAGGGGGCA GCAGACCAGG 180

GCAGTTCAGA GTATGGGGTC AAACCCAGGT CCCTGTCCCC ACTCCACCTG TGGATTTACC 240

CTGGATTGGG CAAGCCCCAT TACTCGAG 268

(2) INFORMATION FOR SEQ ID NO: 75:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 2 86 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ -ID NO: 75:

GAATTCGGCC TTCATGGCCT ACGTGAACAA GACCCTCCCA AACCTTCAGG TAGTCAACCA 6 0

CCAGCAAGGC CCCCACCACA GACACATCCT GAAGCTGCTG CCGTCCATGG AGGCCACTGG 120

GGGCGAGAAG TCCAGCACGC CCATCAAGGG CCCCAAGAGG GGACATC CTA GACAGAACCT 180

ACACAAG CAT TTTGACATCA ATGAGCATTT GCCCTGGATG ATTGTGCTTT TCCTGCTGCT 24 0

GGTGCTTGTG GTGATTGTGG TGTGCAGTAT CCGGGAAAAG CTCGAG 2 86

(2) INFORMATION FOR SEQ ID NO: 76:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 199 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76:

GAATTCTAGA CCTGCCTCGA AAATACACTG TTACTATCTT AATCTCAAGA GTGTCATTAC 6 0

AGTGAGAATC TCATTTAAAA GCATACCAGT GAAATTAATA GCAGTGCTTA TCAAAGAACA 120

CTGAAATCTG TGAGAAT CTT TCTAGG AG CA TTCTTTTCTT CTTTTAGTTC CAAGTTCCAG 18 0

GTAGGCCATG AAGGTCGAG 19 9

(2) INFORMATION FOR SEQ ID NO: 77:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 233 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

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<D) TOPOLOGY : linear
(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 77:

GATTGAATTC TAGACCTGCC TCGAGTTCCA CGTCCATGGC CATCCTGAGC ATGCTGCAGG 6 0

ACATGAATTT CAT CAACAAC TACAAAATTG ACTGCCCGAC CCTGGCCCGG TTCTGTTTGA 12 0

TGGTGAAGAA GGGCTACCGG GATCCCCCCT ACCACAACTG GATGCACGCC TTTTCTGTCT 18 0

CCCACTTCTG CTACCTGCTC TATAAGAACC TGGAGCTCAC CAACTACCTC GAG 23 3

(2) INFORMATION FOR SEQ ID NO : 7 8 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 78:

GAATTCGGCC TTCATGGCCT AAGAATAGAG AAAACGTTTT CAGCAGGCTT CACAGAGAAA 6 0

CCAAACAATA TTTAGAATAT GACAG CAT AT GAAGAGTCTG CTACTCTCCC AGTGACCCAT 12 0

ACTTTCTCTT CCATCTCTGC TGGTTCTCTC TACTACCGAT TCTTTCTTGC TGTTCTCCTT 18 0

CTCCATCACC GTGACTTCTA TTGCCTTACT CTAATGTCTT GTCTTCTGTG TTACCCTTCT 24 0

GTGTGTTTTG CATTCAGAAC TCCCCCTCCG CTCGAG 276

(2) INFORMATION FOR SEQ ID NO: 79:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH ; 273 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 79:

GAATTCGGCC TTCATGGCCT AAAAAAAAAA AAAAATCCCT GGCTGAGAAC TATTGGATTA 60

GGGCCTCCNG TACCTATCTT TGAGGGGGAA AGGATG CTAC CATCAACTTT TCTGAATGCC 120

AGGAATG CCT TTTAGTATAG TTATTTCACT TACTATTTTA TAGCATATTT TAATTGTATA 180

GTAAGCATTG TGTCTGTTTT ATGGTAAGGA AACTAAAATT GAGAGATTAG GCTGCTCGTG 24 0

GTGGCTTATA. CCTTGTAATC CCAAGCACTC GAG 273

(2) INFORMATION FOR SEQ ID NO: 80:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 284 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 80:

117

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GAATTCGGCC TTCATGG CCT AGCGAAATGA CGAAATCTAG CCCTTTGAAA ATAACATTGT 6 0

TTTTAGAAGA GGACAAATCC TTAAAAGTAA CATCAGACCC AAAGGTTGAG CAGAAAATTG 12 0

AAGTGATACG TGAAATTGAG ATGAGTGTGG ATGATGATGA TATCAATAGT TCGAAAGTAA 18 0

TTAATGACCT CTTCAGTGAT GTCCTAGAGG AAGGTGAACT AGATATGGAG AAGAGCCAAG 24 0

AGGAGATGGA TCAAGCATTA GCAGAAAGCA GCGAAGGGCT CGAG 284

(2) INFORMATION FOR SEQ ID NO: 81:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 84 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 81:

GGGAACTGGA GG AAAAC CAT CACAAGATGG AGTGCCAGCA AAAACTGATC AAGGAGCTGG 6 0

AGGGCCAGAG GGAAACCCAG AG AGTGG CTT TGACCCACCT TACGCTGGAC CTAGAAGAAA 120

GGAGCCAGGA GCTGCAGGCA CAAAGCAGCC AGATCCATGA CCTGGAGAGC CACAGCACCG 180

TTCTGGCAAG AG AG CTGCAG GAGAGGGACC AGGAG GTGAA GTCTCAGCGA GAACAGATCG 24 0

AGGAGCTGCA GAGGCAGAAA GAGCATCTGA CTCAGGATCT CGAG 2 84

(2) INFORMATION FOR SEQ ID NO: 82:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 311 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 82:

GAATTCGGCC TTCATGGCCT ACTGTGTTGA CTTGGTGGCT TGCTTGATAA GAAGGTTTTA 60

TGAAGCACAG CAGATATCTC AG CTGCTAAT CCTGTAAGCC CTTTACCCAT TCTCGCTTTT 120

CTCTGCTCTT GCCACATCAT GAATAGATTG GTATACTATT GTGGGATACT TCTAGTTTTA 180

GCACATGATA TAGG TTATGG TTAATGTTCC TTTCCATCTT CCTGGTTACT GATAATGTTC 240

CTTTTCTGTA GATGGGTCTA TTCGATGGAA GAGTTTCAGC TTTGTTCGTG TTATTTCCCT 3 00

GGGACCTCGA G 311

(2) INFORMATION FOR SEQ ID NO: 83:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:83:

GAATTAATCG TAAGAGAACC TCAGCATTGT GCACGATAAG AGAATGTGTC AGTATTTCAG 6 0

GGTTCTACAT TTTATCTGTA AAATGTGACT TTTTTTTTTT T TTAT CACAA CAGAAGTAAA 120

ATGTTGCTTT GTACCTGGTG TCTTTTATTA AGAATTTACT CCCCCCATTT CT CACAGAG A 180

ATAACAGTCG GGAGTCATTG TCACAATATA ATAGAAATGT TAGCAACCAG ATTCATGTAA 24 0

118

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GGACTAAGTG GTCCTCATGA ATTGCATTAA GACTCTGTAC TGCTCATATT ACACTCCATC 30 0

CTCTCTGTAG TTTGCTGGGT ATTCTCGAG 32 9

(2) INFORMATION FOR SEQ ID NO: 84:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 312 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84:

GAATTCGGCC TTCATGGCCT AGAAAGACAT CATTTAAGTN CTTTTAACAT TTAGTTTGTG 6 0

GTCATAAGTT GACCTTTATG TGCTTTCTGA ATTGGAACTT AAAATAATCT TTAATT CATT 12 0

ATTTTTTCTA CTTCTAGGCC AGTTTTGAGT TTAATATTTA TAAAAGGTTA GATAGTTATA 180

GATAGGATTA TTTTGCAGTT TTGAAACAAC ATACAAATTG TTATAGATTT CAGAG TAGGG 24 0

CTAATCACAG GAAAGACAAA AGTCAGAATG CTTNAGGTAA GCCCCTTCTC ATTATATAAG 3 00

ATCAAGCTCG AG 312

(2) INFORMATION FOR SEQ ID NO: 85:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 85:

GAATTCGGCC TTCATGGCCT AAAAACTTTC AACTTAGAAA AACTAG CAAG GGATTGTTCA 60

CCCTTACCCC AGTGGTTGGT GCTAGAGAAA AAATGGAGGA TGTCTGTTCC ACGCAGACCC 120

TGGTGGTTTA AAACACACAT ATAGATGGCT CTGGGACCAT CAAAATAGCA GCAGCAAAGA 18 0

GCCACTCCAC CAGCCTCCCC TCCACTCCCC CAGGCCCCAC ACAGCAGAAG GCTCCAGCCA 24 0

CTTTTTGGAA GCCTGTAGCC TGGCTCCATC TTGCCCTGTG CCACAAATGC CCATGGCCCT 3 00

CGAG 3 04

(2) INFORMATION FOR SEQ ID NO: 86:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 291 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 86:

GAATTTTGAA CACTAAAGCT TTGGATACAC AAATTTATAA CATCTTATTT ATAAATCAGT 60

GGTGTACAGA AAG CAGAG AT CCCATAATCA AGCATGG CAA ACATGTTGAA GAATATGCTT 120

ACAATGATTT CTGCTATAGA TTTCATAATG GGGATTCAGA GAAGTAGAGT TATGGTGCTG 180

GTTCACTGCA TTGATTGGAT CAGGCGCTGG AAACTCTCCC TGATAGATTT TATTCTCACC 24 0

TGTTGGGCAA TTTCCAGAAT ATTCTGCTGT AATTTTACAT GTGGGCTCGA G 291

119

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(2) INFORMATION FOR SEQ ID NO: 87;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 23 base pairs

(B) TYPE: nucleic acid

( C ) STRANDEDNESS : doubl e

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 87:

GAATTCGGCC TTCATGGCCT AGCTAGAAAA AAAAAAAAAA AAGCCCTTTT CAGTTTGTGC 60

ACTGTGTATG GTCCGTGTAG ATTGATG CAG ATTTTCTGAA ATGAAATGTT TGTTTAGACG 120

AGATCATACC GGTAAAGCAG GAATGACAAA GCTTGCTTTT CTGGTATGTT CTAGGTGTAT 180

TGTGACTTTT ACTGTTATAT TAATTGCCAA TATAAGTAAA TATAGATTAT ATATGTATAG 24 0

TGTTTCACAA AGCTTAGACC TTTACCTTCC AGCCACCCCA CAGTGCTTGA TATTTCAGAG 300

TCAGTCATTG GTTATACATG TGTAGTTCCA AAGCACATAA GCTAGAAGAA GAAATATTTC 360

TAGGAGCACT ACCATCTGTT TTCAACATGA AATGCCACAC ACATAGAACT CCAACATCTC 420

GAG 4 23

(2) INFORMATION FOR SEQ ID NO: 88:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 172 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:8B:

GCGATTGAAT TCTAGACCTG CCTCGAGCTT GGGGGGATTA CAGTT CAACA AGAGATTCAG 60
G CAG AG ACAA ATATTCCAAA CTATATCAGG AATTAAGTAG GCTTTGCTGT CCTTTTGCAG 12 0

CTTTGAGTCA AC CCATATGA GAGTGAATTC TCCGATCCTG TACATACTCG AG 172

(2) INFORMATION FOR SEQ ID NO: 89:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 260 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 89:

GAATTCGGCC TTCATGGCCT ACCCGTGTTG TCCAGTATAC CTTATAACAC TTAGCCACTT 60

CTCCCCACCC TCCAGAAGGG GTCCACGTTG AATTCTGAAT CATCTTGAAA ATAAGATTCC 120

AACCACAAAA AAAATTTAGC CATTTCTTTA CTAAAAAAAA CCAAAAAACA AATCTGTTTT 180

ATAAT CACAG ATTTTTAGAC AAATTTCTTG TAT CAGGAAG AAATACAAAT TTTGTCATGT 24 0

TTCTCAAGCA GTGTCTCGAG 260

(2) INFORMATION FOR SEQ ID NO: 90:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 50 base pairs

120

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(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 90:

GAATTCGGCC TTCATGGCCT AAACTAAGAT AAAAATAAAC AGATAGGAGA GCTGAATTCC 6 0

ATTTCAAGTC CTCATGTATA TGCTTACAAA GTTCCAAATT AAGCTTGGGA CTGGTTCTTA 120

CATGGCAGGT AATCCAAACC TTTTCTATTT ACTGAAGATT TTCAGCTCTC TTACAGAAAT 18 0

ACACAGGCTA CCATTAAAAT TGTAGGGATA AATTTTAAAT TGAATTTGAA AATAAGAGCA 24 0

AGTACTCGAG 250

(2) INFORMATION FOR SEQ ID NO: 91:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 260 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:91:

GAATTGAAAC ACAGAGTTGT TCTGCTGATA GTTTTGGGGA TACGTCCATC TTTTTAAGGG 60

ATTGCTTTCA TCTAATTCTG GCAGGACCTC AC CAAAAG AT CCAGCCTCAT ACCTACATCA 12 0

GACAAAATAT CGCCGTTGTT CCTTCTGTAC TAAAGTATTG TGTTTTGCTT TGGAAACACC 180

CACTCACTTT GCAATAGCCG TGCAAGATGA ATGCAGATTA CACTGATCTT ATGTGTTACA 24 0

AAATTGGAGA AAGTCTCGAG 26 0

(2) INFORMATION FOR SEQ ID NO: 92:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 54 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 92:

GAATTCGGCC TTCATGGCCT AATTT CATCT TTTTTTCCTG GTGCTGCATA AACATATATT 60

AAATGTTGTT ACTGATCCCT AGTACTG TTG ATT TGTGACC CTTCTCCTGA GGGAGACTAA 120

AGCTGCTTGA GCTAAAGGCT TTTGAGACAT CCCATACGGT TCCCTGAACA AAGTTTTCTC 180

TCCTGACCTC AGTTCTCTTG ATGACCTTGG CAAGTGGGCC CGACTAGTTG GACACTAATG 24 0

AGGCATCGTA ACATGCCGGC CCCATCCTGT CCATTCTGTT CTCTTTGCCA TCTAGCATTC 3 00

AGTGTTGTGT CTTCCTAGTG GGCATGAAGA CGGCTTTAAA ACCATCCACT CGAG 3 54

(2) INFORMATION FOR SEQ ID NO: 93:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 93 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

121

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(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION; SEQ ID NO: 93:

GCTGAAAATG CAAAACATGA AGAAAGTGAT TGAGGCAATT CGAGTGGAGC TGGTTCAGTA 6 0

CTGGGACCAG TGCTTTTATA GCCAGGAGCA GAGACAAGCT TTTGCCCCTT TCTGTGCTGA 120

GGACTACACA GAAAGTCTGC TCCAGCTCCA CGATGCTGAG ATTGTGCGGT TAAAAAACTA 18 0

CTATGAAGTT CACAAGGAAC TCTTTGAAGG TGTCCAGAAG TGGGAAGAAA CCTGGAGGCT 240

TTTCTTAGAG TTTGAGAGAA AAGCTTCAGA TCCAAATCGA TTTACAAACC GAGGAGGAAA 3 00

TCTTCTAAAA GAAGAAAAAC AACGAGCCAA G CTCCAG AAA ATGTTGCCCA AG CTGG AAG A 3 60

AGAGTTGAAG GCACGAATTG AATTGTGGGA ACAGGAACAT TCAAAGG CAT TTATGGTGAA 420

TGGGCAGAAA TTCATGGAGT ATGTGGCAGA ACAATGGGAG ATGCATCGAT TGGAGAAAGA 4 80

GAGACTCCTC GAG 4 93

(2) INFORMATION FOR SEQ ID NO : 94 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 293 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94:

GAATTCGGCC TTCATGGCCT ACACACGGCC AAATTTGAGG GCATTCTCAC ATG TGTTCTT 60

CTCTCAAAAC CACTGGGGTT GACAGATCCA GGAGGCTAAA AAAAAGTGAC CTCTATAATT 120

CTTTAAAGGT GCTATTTTTA GAANATTGTA TAATTTATTC ACAGTATATC TAAAACAGAA 1B0

TTAAGGACAA TTAAAATATC TTATGTGACA GCCTTTATGT CTAGTCACAT TTGATGAAAT 24 0

AAAAAACTTC TGAATCTGAA TAGAAGTTCT ACTGTNTCAG GATTGAACTC GAG 2 93

(2) INFORMATION FOR SEQ ID NO: 95:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 B0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 95:

GAATTCGGCC TTCATGGCCT AAAAAGACAG GAAAATAAGT CTCTTTGTAT CCTTATTAAT 60

CATTTGAAAT TATG CTATAA TAT TTTTTAA AACT CACCTG TTTGGTTCTG GGTGAAGCAG 120

TTCCTGAAGG AGTGTTTTGT CAGAATATAT TGTTAGG TG A ATAGAGGGTT CTGTGGCCAA 180

GTAAGTTTGG GAAATAGTGG GTTAGACAAA GTTGAGTTAC TGTTGGCCTT TCAGACCTTT 24 0

GATACGCTAA TGTGCATTTT AAATCTCCAA GAAGCTCGAG 2 80

(2) INFORMATION FOR SEQ ID NO: 96:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 279 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

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{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 96:

GAATTCTCCA GCCTGGGTGA CAGAGTAAGA CTCCATCTCA AAAACAAAAA AACCCAACAG
GATAAAATTT AATAGGAGTA AATATAAAGT TCTACGTTTT GATTTTAAAA AT C TAGGTAC
TGTATAGTGT GTATTAG TTG GGGTTCCTTT TTTGAAACTT AATCTTGCCT ATAAAACACA
AAAGAGTTTA AGATGATATT GAGACTCCTC CTGTCCTCAT TCCTTTTCCT TCCTAATAGC
TCAGTCCTGA AG CT CTTAGG TGAGGCAGAA CAACTCGAG

60
120
180
240
279

(2) INFORMATION FOR SEQ ID NO: 97:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 07 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 97:

GAATTCGGCC TTCATGGCCT AGGATACCTT CATTTCAAGG AG CCTCTTTA CAGTAACTGG 60

G CT AAACATT TTGTTGTCGT CCGTCGGCCT TATGTCTTCA TCTATAACAG TGACAAAGAC 120

CCTGTGGAGC GTGGAATCAT TAACCTGTCC ACAGCACAGG TGGAGTACAG TGAGGACCAG 180

CAGGCCATGG TGAAGACACC AAACACCTTT GCTGTCTGCA CAAAGCACCG TGGGGTCCTT 24 0

TTGCAGGCCC TCAATGACAA AGACATGAAC GACTGGTTGT ATGCCTTCAA CCCACTTCTA 300

GCTCGAG 307

(2) INFORMATION FOR SEQ ID NO: 98:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:98:

GAGCTGTGTC AG CATCGATC AGGGGTCTGT AGACAAAAAT TCCCAAAGAT TTGAGACTTT 60

ATTGGGGGAA ACAGATCACT GGCGGGGAAT AAGCCACAGG CCAAAGGAGG AAATGCTGGG 120

ACCAGAAGTC CCGCTTGCCG CCTTTTGCTA AAAGTTCCGC ACGCCTGCTC GGCGTGGGCG 180

CAAGCATAGT GTCGTCGGGG CTCTGCGACG TCTGATTGGC TCTCTGCAGT GCACCGTCGA 240

GGTAGAAGGC TCAGCTCCTA GTCGCTCCCA AATTACTTTG TTGGTGCTCG AG 2 92

(2) INFORMATION FOR SEQ ID NO: 99:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 99:

GAATTCGGCC TTCATGGCCT AGCTTGAGGA ATGACCCAAC TCTCTCTGGA AAGTCACTTT 60

123

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GCCTCTCTGT TCTGGTTCTC TCATTTTATA AAGTGCCTTC TTCCTTTCTG CATTTATAAG 120

TAAACATGAG AAAAATCTGA AAAGACTTCT TCAGGATGTT TAAGGAAACA AATGTTGCTT 180

TCCTTGGGTT GGGTCGTTTC AT AAGAG TG A TGTTTGCCAT AAAACTGGAG CCTCATAGAC 24 0

GATCCTGCAG GGAGGAAGCT TTCCTTGGTC ACCTGACTCA TGTGTTTATA TATAGTATAG 3 00

AGGAGAGGTA TT CCAAAAG A CCCGTCGCTT TTCCTGTGTC CCACAGCTGC CTGTAGAGTT 360

GTGG CACCAT AAACTTTAGC AGCTGGAAAT CCTCGAG 3 97

(2) INFORMATION FOR SEQ ID NO; 10 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 70 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 100:

GAATTCGGCC AAAGAGGCCT ATTAATTTAA TAAAGCCATA TCATACCTCT CTTTAACATT 60

GTTAAAAGGA AACTGTGTGT GTGTATTTGT GTTAATGTTA ANTTCTCTTC ATTTTTGTGC 12 0

TTGGGGGGCT GTTTATTTGA GGATGGTCGG GGGGCGGGTG GGTCAGACCC ATCCATCCCC 18 0

CATGGAAGAC CAGACCCATC CATCCCCCAT GGAAGACCAT TCCCGTGTGT TCAGACTGGC 24 0

AGGGTACTTC CATAGACAGG AACATTCTGG ATGCTCTGAT GCTGAACACT ACCAGAATCG 300

GCCATGGATT TGCTTTGAGC AAACACCCCG CAGTCAGGAC TTACTCCTGG AAAAAGGACA 3 60

T CTTCTCGAG 3 70

(2) INFORMATION FOR SEQ ID NO: 101:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 40 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 101:

GAAAAAAATA GACAAAACTA TGATGTAAAA ATG CTTAAAA ACAATTATTC CTCTCTGCTA 60

ATTTTAATGC AAAATAAATG ATGC TAGCAT TTAATATGTT TATATGATCT TGTTTTTAGG 120

ATTGAAATTT TAATACAATG GCCTTTTGTA ACTATTTTTA CTATTATAGC TCAGGTGTTT 180

GAATTCTCTC TACCCCACCT ATCACCCCTA TCCCCTAACA AAGAGTCTGG CTTCATAAAT 24 0

ACTGTTGAAT GAAAATTGGT TCTCTAAATG GTTAACAAGA TGAATCCACA TAAATCATAA 300

TTCAG TACTG AGGAACCGAA TTTATACCCA GCGTCTCGAG 34 0

(2) INFORMATION FOR SEQ ID NO: 102:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 70 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 102:

GAATTCGGCC TTCATGGCCT AGATTGAATT CTAGACCTGA TGTGAGAATG ATGGGCTTGG 60

124

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AGTGTTCTGG AAATAGCTGG GAGGCCTGTG TGTTTAGGAG CGCCTTAAAC AGTAGGATAT 120

AAGGGCAGAG AAGTAGCTGG GAACTGAGAA GAACTTTGGC TGTTATTCTA GTAAGACTGA 180

AAATTTCAGG TGGGATTTGA ACAGAGATGT GTGGTGATCT GACTTGGTTC ATTCTGCTGT 24 0

GGTGAAGAGA CTGGAGGTGC GGGGCAAGTA TGGAAGCATG GAGACCATTA ATTTATGGGG 3 00

GCAATGGTAG AGGGAAGAGA AACAATGCTA TTAACTGGAG TAGGAG CACA CAGAGAACAA 3 60

GCCACTCGAG 370

(2) INFORMATION FOR SEQ ID NO: 103:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 270 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS : double
(D) TOPOLOGY: linear

<ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 103:

GCGATTGAAT TCTAGACCTG CCTTGAGATC ACCGAGTGCT TCATCTCTGA CAGTTCCTCT 60

GACCAGATGA CCACAGGCAC CAACGAGAAC GCCGACAGCA TGACATCCAT GAGCACACCC 120

TCAGAGCCTG GCATCTGCCG CTTTACCGCC TCACCACCCA AGCCCCAGGA TGCGGACCGG 180

GGCAAAAACG TGGCTGTGCC CATCCCTCAC CGGGCCAACA AGAGTGAGTG CTCAGACCAC 24 0

CTCCCAGGCA GTGCCCCCCC GACTCTCGAG 2 70

(2) INFORMATION FOR SEQ ID NO: 104:

<i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 86 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 104;

GAATTCGCCT TCATGGCCTA AT ATG CTTAT GAATATGATG TTGATGGACA GCTCCAAACA 60

GTTTACCTCA ATGAAAAGAT AATGTGGCGG TACAACTACG ATC TGAATGG AAACCTCCAT 120

TTACTGAACC CAAGTAACAG TGCGCGTCTG ACACCCCTTC GCTATGACCT GCGAGACAGA 180

ATCACTCGAC TGGGTGATGT TCAATATCGG TTGGATGAAG ATGGTTTCCT ACGTCAAAGG 240

GGCACGGAAA TCTTTGAATA TAGCTCCAAG GGGCTTCTAA CTCGAG 286

<2> INFORMATION FOR SEQ ID NO: 105:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 91 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 105:

GAATTCGGCC TTCATGGCCT ACTTAAATCT TAGATG CTAA TGGGAGAAAC TGATTTTTTA 60

AAAAACAGGG AAACTAATTA ACAT TTTATC AG ATATG CTA TGAAGTAAAC AGTTGAAGAC 120

TGACAGTCCA GTGGATACCG AGGAGTTCCT TTAGATACCC TGGTGAGGTA AGGACACAGG 180

CAAGGGGAGA GCTGAGACCT GAATATGAGG AGAAGCCAGG CG AG CACACA ATAGGGCAGA 240

125

ill

Ill

III ill I

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AAGGAGCAGT AGGTCAAAGC CTGAGGCAGG AGAGAGCTTG ACTGACTCGA G
(2) INFORMATION FOR SEQ ID NO: 106:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 33 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 106:

291

GAATTCGGCC
GATGATTTCA
CTGCTGTTGA
AGAATATAGG
CTTATGAAGG
AGTATTAGTT

TTCATGGCCT
ACAACCTGGA
TGGAGTCAGA
GAGTACTTGT
TACCTGTATT
CAGCAACCAC

AGAAATGGTT
TGTTTTCTTT
CAGTAAACAC
TCTCTGTTGA
TGTATGGACT
TGAGAAACAA

CTGAAAGCGA
CTCCTCTTTG
GTGGCTTGGA
TTCAACTTTT
CTGAATAAAG
GCACTCGAG

CAGTAGAGAG
CTTCCATTCA
TAACACCCAT
ATGTCTCCAG
AAGAATTCAT

ATGCAGTTGT
TCTCTGTTGG
CATCCTATGA
TAACATTGCG
TTGTTTAGCA

(2) INFORMATION FOR SEQ ID NO: 107:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 107:

GAATTCGGCC
TAAAGACCCG
CAAAAATTAT
CAATGTTCTA
ATCATCACGA
AAGAATAAAG
AATGTCTTCA
GTCTGAATCG

TTCATGGCCT
GTACTACCAG
CTGCCTCCTG
GGAGCTGTTA
ATGGAAACTG
GGGAGGCTTG
CCTTTGCCGG
GAGCTCGAG

ACATCATGTC
CTCGTTTCTT
AAATGAAATC
ACAAGCCACT
TAAGCAATGC
ATAG TTCTGA
GGAAAAAAAG

AAAGAGTACT
CACTCAACCT
ATTTTTCACT
TTCATCAGCA
AAGCAGCAGC
AATGGATCAC
TGACAAGAGA

ACATACAGTT
GACAAGAATT
CCTGGAAAAC
GGCAAGCAAT
TCAAATCCAA
AGTGAAAATG
GACGACTCTG

TGGAATCTCC
TCAGTAACAC
CTAAAACAAC
CTCAGACCAA
GCTCTCCTGG
AAGATTACAC
ATCTTGTAAG

{2) INFORMATION FOR SEQ ID NO: 10 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 98 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
{D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10 8:

60
120
180
240
300
339

60
120
180
240
300
360
420
43 9

GAATTCGGCC
TCCAAATGTA
ATATAACAAA
ACTTTTTCTT
GAACTGGAAT

TTCATGGCCT AATTGAATTC
AAATTTACTA AGGCTTTTCA
TGAATTTGGT TGTAGCTAAC
TTTTGTTGAG GTATAGACAG
GCAGGCCAAA AGCTGGTCCT

TAGACCTGCC
TGTGGAAGTA
GTGTTGTACT
TAGAGTGATA
TTCCAGATGA

TCGAGAGGCA
GAATG CATAT
AGTAAAGGTC
CCGATACATG
ATGTAACCAA

GGTCTAGAAT
ATCTTTCTTG
CACCTGCTAA
AGGAAAATGA
GACTCGAG

60
120
180
240
298

126

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(2) INFORMATION FOR SEQ ID NO: 109:

U) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 55 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 109:

GAATTCGGCC TTCATGGCCT ACACTCTCAA ATATGTGGCC TTTAACGGGA CCAAAGTAGG 6 0

AAAGCAGATA GTGGAAAACT TCTCTCCCAA TCAG AC CAAG TTCACGGTGC AAAGAACGGA 120

CCCCGTGTCA CGCTACCGCT TTACCCTCAG CGCCAGGACG CAGGTGGGCT CTGGGGAAGC 180

CGTCACAGAG GAGTCACCAG CACCCCCGAA TGAAGCTTAC ACCAACAACC AAGCAGACAT 24 0

CGCCACCCAG GGCTGGTTCA TTGGGCTTAT GTGCGCCATC GCCCTCCTGG TGCTGATCCT 300

GCTCATCGTC TGTTTCATCA AG AGGAGT CG CGGCGGCAAG TACCCAATAC TCGAG 3 55

(2) INFORMATION FOR SEQ ID NO: 110:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 07 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 110:

GAAAAAACTG GGTCAAAGAA TTACGGAAAA TGTTGGGAAA TGAAATCTGT TTATGTATAG 60

TTGGTAATAA AATAGACTTG GAAAAGGAGA GACATGTTTC CATTCAAGAA GCAGAGTCGT 120

ATGCAGAATC TGTGGGAGCA AAACATTATC ATACTTCAGC CAAACAGAAC AAAGGAATTG 180

AGGAACTCTT TCTTGACCTT TGTAAAAGGA TGATAGAAAC AG CACAAGTG GATGAGAGAG 240

CAAAAGGCAA TGGCTCTAGT CAGC CGGGAA CTGCAAGGCG AGGTGTACAG ATTATTGATG 30C

ATGAACCTCA AGCCCAGACC AGTGGTGGAG GGTGCTGTTC TTCTGGATAA CTGTTCACG C 360

CTAAGAAATT AAAAGACAGA ACAAAACTGT GGATCATTGC CCTCGAG 4 07

(2) INFORMATION FOR SEQ ID NO: 111:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 95 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 111:

GAATTCGGCC TTCATGGCCT AAAAGAAAGT ACATTAAAGC AACTTGCATC TCAAAACAAT 60

ACATTTCTCT GGTTGAAGTT TTAGTGAAAA TCGATTTATT CCTCCTCTGA GTTTTACCCA 120

ATGGGTAAAG TTGTCTAAAT ATGGGATTCC TTAGAATCCA TCCTCCTTCC CAAGCATTTC 180

CCCATGTTTC CTTCCACCCC CAAATTCTTA CCCCATTTCA GGCAGAGCTG AGCAAACATA 24 0

AGCCTTCTCT GAAGTATTGA GGGAAAGTCT GCTAAACGGC TAAACTACTT AAGGAGCTAA 300

CAGAAAAGGT TGTATCAGAG AAACAGTGGA GAAACACAGG TTTCTAATTA TATCTGGCAC 36 0

TGGAGAGAAT GTCAAAGG TA TTGGCCCAGC TCGAG 3 95

127

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(2) INFORMATION FOR SEQ ID NO: 112:

{ij SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 01 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 112:

GAATTCTAGA AACTACAGTA GTGGGACACA TAACATAGAA GTAATCGTCC AGGATTCTGC 6 0

TGGAAGAAGT AAGAGTGTTC ACCACATATT TTCTGTT CAA GAGAATAATC ATCTCAGTTT 120

TGATCCCCTG GCAT CATTT A TTCTCCGTAC TGATCACTAC ATCATGGCCC GGGTCCTTTT 180

TGTGCTGATT GTGCTGAGCC AGCTCACCAT TCTCATTATT TTTAGATATC GAGGATACCC 24 0

AGAG CTTAAA GAACCTTCAG GGTTTATAAA TCTGACCTCA TTTTCTCTTC AATGTCTCGA 3 00

G 301

(2) INFORMATION FOR SEQ ID NO: 113:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 268 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS ; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 113:

GAATTCGGCC TTCATGGCCT AAGCATG CTG TCTTGTGATG GTGATTTCAT GTGTTTTCTG 60

CATGGGATTA TTAACGGCAT CCATTTTCTT GGGCGTCAAG TTGTTGCAGG TGTCCACCAT 120

TGCGATGCAG CAGCAAGAAA AACTCATCCA ACAAGAGAGG GCACTGCTAA ACTTTACAGA 18 0

ATGGAAGAGA AGCTGTGCCC TTCAGATGAA ATATTG CCAA GCCTTCATGC AAAACTCATT 24 0

AAGTTCAGCC CAT AACAG CA GTCTCGAG 26 8

(2) INFORMATION FOR SEQ ID NO: 114:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 260 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 114:

GAATTCGGCC TTCATGGCCT ACCCGCATCC CAGCTCTATT TAAAAAAATA AAGAAGAAGA 6 0

TAATTCATTT CCTTAAGCTG CCCTTACACT ATTAGTCAGG AATGTTTGTG TTCACTTCCA 120

CTACATACCT TACGATCTCT TTTGCTTTGC TTTTTTTCAG TCAAGTCTCT ATTTATGAGG 180

TGGACAAGCA AGATTGT CGC AAATTTTGCA CTACTGGCAT CGATGGAGCC ATGACAATTT 24 0

GGGATTTCAA GACCCTCGAG 260

(2) INFORMATION FOR SEQ ID NO: 115:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 259 base pairs

128

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(B) TYPE: nucleic acid

(C) STRAND EDNESS : double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 115:

GAATTCGGCC TTCATGGCCT AAACATTTTC TGAAAAACGT GATAGAAAGA AGGAGGAGCT 6 0

GTTTCTAGGA GGGAAATAAA TAATTTGGCA GGAGACTTTT TGAACTAGAT ATCTATTGAA 120

TAACAAAGTG ACAATGTTCC CCATCCTCTC ATTTCCATTC CCAATTTTAC TTCTCGTCCC 18 0

AATTCAAATC ATTCTTACTT ATGATCGGCG CTATGTCAGT GCCTCTCAGC TGGTCTTCCC 24 0

AGACCCAGTC ACCCTCGAG 259

(2) INFORMATION FOR SEQ ID NO: 116:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 23 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 116:

GAATTCGGCC TTCATGGCCT AATTACATTT ATGCAACCAA GCTATCAAAA GGACTGGCTG 6 0

TCCTTGGGAA TGAAACGTAA CAAAATCGTC AATAGAGTAT TATTGGAAAA GATTG TTTTC 12 0

AGTCATGAAC TAGCTATTTA AATGAGAAAA CAAATGTAAT GATGCTTTCT GTCATGATTT 180

TATAAATAAA TGTCAATTGT AGGAAATTGG AAAAATAAAT GAAAAAGAAA AACTCGAG 238

(2) INFORMATION FOR SEQ ID NO: 117:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 279 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 117:

GAATTCGGCC AAAGAGGCCT ACCCTAGACC TGTTTTCTGT TCTCTACTCT TGAAATGCTA 6 0

ATGACCTTCA TGACCAGAGT CCGCTATTGC AGTTTGTGGT TGACAGGCAT CTCTCACTCA 12 0

CTGTGCTGCA ACTCAACTCT TTATCTTCAA CCAAACAGGG CCTCCCCGCA GCTTTCCCAC 180

TGCCACTCAG TGGCACTCCA TCCAGGGTTT CCAAAGTGTA AGACCCCGGA ATTTATCTTT 24 0

GACACTTCCA TCTCCCTCCA CCCCTCATCC AATTCATCA 279

(2) INFORMATION FOR SEQ ID NO:llB:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 656 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

129

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 118:

GAATTCGGCC AAAGAGGCCT
CTTGAACTGG CAAGCTTACA
GAAAGGCTGC TTTGGAAAAA
AGGAAGCTGA GGCTCGTATG
GTGGAAATGG AAGTAAAAAT
ATCTGTTCCC TGCTGGAACA
ATTCTTCCTC TGGAGTCAAA
AAAAACTTGA CCCTCATCAA
AAGAACATGG AGTGGTACCT
CATATACAGA CTTCACCCCT
AAACATACCC AGTAAATACA

AGTTATAATG ATGGAAGAAG TGGAAAAACT TTGTGATCGG
GTGCTTGAAT GAAACACTCA CAT CATG CAC AAAAGAATAG
CAGATAGAAG AAATAAATGA G CAAAT C AG A AAAGAGAAAG
CG ACAAG CAT CTAAGAACAC AGAGAAATCA ACTGGTGGAG
TGGTCAGAAG ATG AT CT AC A ATTACTAATT AAAGCTGTGA
AATTCAAGAT GGGAAGTTAT TGCTAATTAC ATGAACATAC
AGAACTGCCA AAGATGTTNT TGGCAAAGCA AAGAGTCTCC
ANAGATGACA TAAATATAAA GGCATTTGAT AAGTTCAANA
CAAGCAGACA ACGCAACGCC TTCAGAACGA TTTGAAGGTC
TGGACAACAG AAGAACAGAA GCTTTTGGAA CAAGNTTTGA
CCTGAAAGNT GGGAAAANAT AG CAG AAAGT CTCGAG

60
120
180
240
300
360
420
480
540
600
656

(2) INFORMATION FOR SEQ ID NO: 119:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 523 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 119:

GAATTCGGCC AAAGAGGCCT AGAGACAAAT AGGTGATACT GAATTTTATA CTGTTTTCTA 6 0

CTTTTCCATT AAAACATTGG CACCTCAATG ATAAAGAAAT TTAAGGTATA AAATTAAATG 120

TAAAAATTAA TTTCAGCTTC ATTTCGTATT TCGAANCAAT CTANACTGTT GTGATGAGTG 180

TATGTCTGAA CCTGTAATTC TTAAAANACT TCTTAATCTT CTAGAAGAAA AATCTCCGAA 24 0

GAGCTCTCTC TAGAAGTCCA AAATGG CTAG CCATTATGCT TCTTTGAAAG GACATGATAA 3 00

TGGGACCAGG ATGGTTTTTT GGAGTACCAA GCAAGGGGAA TGGAGCACTT TAAGGGCGCC 36 0

TGTTAGTAAC ATGAATTGGA AATCTGTGTC GAGTACCTCT GATCTAAACG GTAAAACAAG 420

CTGCCTGGAG AGCAGCTGTA C CTAACAAT A CTGTAATGTA CATTAACATT ACAGCCTCTC 480

AATTTCAGGC AGGTGTAACA GTTCCTTTCC ACCAGATCTC GAG 523

(2) INFORMATION FOR SEQ ID NO: 120:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 111 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
tD) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi} SEQUENCE DESCRIPTION: SEQ ID NO:120:

GAATTCGGCC AAAGAGGCCT AATTTCTTCC TGTGATATGA GAATTTCTTT TCTTTCAGCA 6 0

GCTTTACCTG CATTTGGCTT TGGCTTTTGC AATCGGCCCC TCATTCTCGA G 111

(2) INFORMATION FOR SEQ ID NO: 121:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 57 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

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(ii) MOLECULE TYPE : cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 121:

GAATTCGGCC AAAGAGGCCT
TGAAAGAAAA NATCACAATA
TTGATGTGGT CCTGAATCGG
CTCTCTAAAC CTCTTTTCAG
AAAGCTTGCT GAGTGATTTA
TCTCTTTTTG ATTTTTATCC
TGGAAGGAAA GTGGGAAGGA
TCATCTGGCT TGATAGGGAA
ATTATAACAC ACACAGCCCC
GGCTCTGGCA, CCTTAATTGG

AACCGCGGCC GCTACTTCGG CCTCTTTGGA AAAAAAAAAG
CAGGGAAAAG TGAGCTAAAA ATCCCGGCAT TAAAAAGCCC
CTATTTCTAT CTGTTCCCTG AGCCTAACCT CAGCGCTGGC
TCCTCTCATT TTGAAAACAG GGCCCATTAC ACATTCTCTG
ACCACATAGT CTAGGGGAGG CACTCATCAA ACATAAGGCC
TATAGTGGTA TCTATCTAGA GGCTGGTGAA GACAGTGTGG
TACACTGAAA TAGGACATAG ACGTAGAGGG GAGTCGATGG
AGTTAGAGAG CTCTCCTGAA CCACAGTTAC AGAGCTTGGG
AGAGAAAACA CTTTGTTTAC CATATTTCCT CTTCTGCTGG
TCAAAAG G C A GCACTCGAG

60
120
180
240
300
360
420
480
540
579

(2) INFORMATION FOR SEQ ID NO: 122:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 257 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 122:

GAATTCTAGG AATGGGTCGG GAAGTTGAGA AT CTTATATT AGAAAATACA CAACTGTTGG 60

AAACCAAAAA TGCTTTGAAC ATAGTGAAGA ATGATTTGAT AGCAAAAGTG GATGAACTGA 120

CCTGTGAGAA AGATGTGCTG CAAGGGGAAT TGGAGGCTGT GAAGCAAGCC AAACTGAAAC 180

TAGAGGAAAA GAACAGAGAA TTGGAGGAAG AG CTTAGGAA AGCTCGGGCA GAAGCTGAAG 240

ATGCAAGGCA ACTCGAG 257

(2) INFORMATION FOR SEQ ID NO: 123 :

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 421 base pairs

{B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 123:

GAATTCCTGT AACTCGGAAA AGATATCAGA GGAATGTTCG TGGCATCAGA GAGAAAGATG 60

AGAGCTCACC AGGTGCTCAC CTTCCTCCTG CTCTTTCGTG ATCACCTCGG TGGCCTCTGA 120

AAACGCCAGC ACATCCCGAG GCTGTGGGCT GGACCTCCTC CCTCAGTACG TGTCCCTGTG 180

CGACCTGGAC GCCATCTGGG GCATTGTGGT GGAGGCGGTG GCCGGGGCGG GCGCCCTGAT 24 0

CACACTGCTC CTGATGCTCA TCCTCCTGGT GCGGCTGCCC TTCATCAAGG AGAAGGAGAA 300

GAAGAGCCCT GTGGGCCTCC ACTTTCTGTT CCTCCTGGGG ACCCTGGGCC TCTTTGGGCT 360

GACGTTTGCC TTCATCATCC AGGAGGACGA GACCATCTGC TCTGTCCGCC GGTCACTCGA 420

G 421

(2) INFORMATION FOR SEQ ID NO: 124:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 123 base pairs

(B) TYPE: nucleic acid

131

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124:

GAATTCTAGA CCTGCCTCGA GAAAATGAAA GTCTTTTCTC AAAAAACTTC TTCCCAGGTC
TGTGAAGCAG CACAGTGGCC CCTTCTGGCT CTCACCTTGT ACCTCGTCCT TGTTTGCCTC
GAG

(2) INFORMATION FOR SEQ ID NO: 125:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 03 base pairs
<B) TYPE; nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 125:

GAATTCGGCC TTCATGGCCT AAGATGGCGT CTCACAAATC ATATGCCAAT TACTGAAATT
GGAGGTGAAA ATATTCTAGA TTTATTGTGG GATATATATA TTTTATGGTG TATGGCTCCC
AACACCACAT GCCACTGAAC TATATAAAAC TTTATGTCAG AACACTTACT TGTGTCATAT
GTAACCCTCT TGCAAATAAT ATTCCCTTAC TACAGATCTG TCCCACTGTT CTCAGAAAAT
AAAACATGGG AACGTTGGAA TGTCTCCTTG CTATAAGATA TTGAATTCTA GACCTGCCTC
GAG

(2) INFORMATION FOR SEQ ID NO: 126:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 508 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 126:

GAATTCGGCC TTCATGGCCT ATGAAGACAA AGCTAACTTA CAAAAG C AG C TGGTTGAAGC
AATGAATACG CAATTAGAAC TTTCAGAACA ACTTAAATTT CAGAACAACT CTGAAGATAA
TGTTAAAAAA CTACAAGAAG AGATTGAGAA AATTAGG CCA GGCTTTGAGG AG CAAATTTT
ATATCTGCAA AAG CAATTAG ACGCTACCAC TGATGAAAAG AAGGAAACAG TTACTCAACT
CCAAAATATC ATTGAGGCTA ATT CTCAGCA TTACCAAAAA AATATTAATA GTTTG CAGGA
AGAGCTTTTA CAGTTGAAAG CTATACACCA AGAAGAGGTG AAAGAGTTGA TGTG CCAGAT
TGAAGCATCA GCTAAGGAAC ATGAAGCAGA GATAAATAAG TTGAACGAGC TAAAAGAGAA
CTTAGTAAAA CAATGTGAGG CAAGTGAAAA GAACATCCAG AAGAAATATG AATGTGAGTT
AGAAAATTTA AGGAAAGCCA CCCTCGAG

(2) INFORMATION FOR SEQ ID NO: 127:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 713 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

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(ii)

MOLECULE TYPE: cDNA

(xi)

SEQUENCE DESCRIPTION:

SEQ ID NO: 127 :

GAATTCGGCC
AAAAATTATG
CTACTGAGTC
CTTCACATAA
ACTACAGTTC
GAACTCCATC
ACATCTTTAT
TCTTGCAGGT
CTGGAGGGGA
CCCTTCCCAC
ATACTAGCCC
CACAGACCCA

TTCATGGCCT
TGTCTGCAAT
TTACTGGATT
AGCAGTTTTA
TTTTCAAATG
AAGGGGACCT
GTATGGAGGC
CTCAGCTTGC
GAGAAGGATT
CCCAGCCCTT
GCCAGCTGTG
CGGAG CTCTC

AGCGGCAGTC
GATAGTTGGC
CTG CCAAACG
CACGGGAAAT
GTCCTAAATT
CTCCAGAGAT
GCCCCAAGGC
GGGGTGGGGG
CTAGGGGTGT
GNTGGTCCCT
GGCCCCAGAA
TGTGTTTGGC

CAGATCACGG
AAGGTCCTGA
TTAAACCCTT
TTATGTGGGT
ACAATTTAGA
ATGGACACTC
CCGACCCCTC
GAGTCATGCC
GGAGTTGGAG
AGGCCAAGCC
AG CC AG CCTG
CTCTCACACA

TTACTGTGAC CTGACTGGAG

TTGTTCTTTG AATGTTCCCT

CAGTCCTTCT GTAGGTCGGG

GATTGGTGGA TATACTTTTA

AAGCAGTATA TGGAATGTAG

TCTTGCTTTA TATCAGGAAA

CCCCAAAGGG GCAGTCCCCT

CAGGGGAGGA GACTTTTTAT

AAAGAGGCTT CCTTGAGCCA

AC CAAGTGAA ACCTTCCAGG

CCTTTTAGCA CTTGGATACA

CACACAACTC GAG

60
120
180
240
300
360
420
480
540
600
660
713

(2) INFORMATION FOR SEQ ID NO: 128:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 277 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 128:

GAATTCGGCC AAAGAGGCCT AAGAGATTCA GGAC CTGCAG AG TCG CCAG A AGCATGAAAT 60

TGAATCTTTG TATACTAAAC TGGGCAAGGT TCCCCCTGCT GTCATTATTC CCCCAGCTGC 120

TCCTCTGTOG GGGAGAAGAA GGAGACCCAC TAAAAGCAAA GGCAGCAAGT CTAGTCGCAG 180

CAGCTCATTG GGCAATAAAA GCCCACAGCT TTCAGGCAAC CTGTCTGGTC AGAGTGGAAC 240

TTCAGTCTTA CACCCCCAAC AGACCTCCAC AGTCGAG 277

(2) INFORMATION FOR SEQ ID NO: 129:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 670 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 9:

GAATTCGGCC TTCATGGCCT AAGGCTACCG ATATTGGAGA AG CTAACTAT GGGTTTTACC 60

ACACGTAACA GCTTTTTGGT GAAATCAGTT GTTATACTAA TAAGCTTTCC TCTAATTGAT 120

TTGAGTTTTG GTTTTTGTGT TTGTATTTGC GGGTTTTGTC TCTTTTGTTT TCTTGTTTTT 180

AGTAAATTGG TTTTTCTTCA ATGTATTTTC TTAAAGTAGT CTAG CTTTAC CCAGTTTCCT 24 0

TGG CAAATTG AAATTTAGGC CATGAAGGCC GAATTCGGCC TTCATGGCCT ACTCAGCCTC 300

CCCAAGTAGC TGGGACTACA GGCGTGTGCC ACTATTCTCA GCTGATTTTT GTATTTTTAG 360

TGGAGACGGG TTTTTGCCAT GTTAGTTGGC CAGGATGGTC TCTCTCTCGA CGTCGTGATC 420

CGCCCGCCTC GGCCTCCCAA ATTGCTGTGA TGACAGGCGT GAGCCACCCC GCNTGGCNTG 4 80

TCCTACCTCT TTTTTAAGAC CTCTTCCTGT AAGCACTGGA TAATCTACTT CTAGTAATGT 540

GAAACTGACT ATATNTTGAA TTCATATGTT TTCAATCAAC CTGTTGCAGT TTATATTTCA 600

CACCCTGCTC CCTTTTGACA GTTTAAGTAC AGATAGTCTC AGCAGTTCTG GAGACCATGT 660

AAAGCT CGAG 670

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(2) INFORMATION FOR SEQ ID NO • 130:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 62 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

Ui) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 0:

GAATTCGGCC TTCATGGCCT ACGACTCTGC TCTATTTACC ACTATCAGGC CAATCCTCCT 6 0

GACATGCTGT TAATATTTAG AAATATTTCT CCAACATTCA GAGTGCCTGG GTACCACACA 120

TGGATGCGAC TAAGATTCTT AAGTCTGGTT TCTAAGAGCT TCTTCAATGT CTCCAACTAT 180

CTTTTCAGGC TCATGTTTGA GACCTTCCTT TCAAGAATAA TTTGCTTGTG ATCTGGTTCA 240

AG CTG AACAG AGATTTTCAG ATGACTCCCA AACTATCTGC AACACATCAG CCCTATTAAC 3 00

TCTTCTCAGA ATGCTCATAC AGAAG CCATG CCAGTGCACA AAAGCCACTT CTGACACCTG 3 60

GCCCTGTCTG ACTCATGGAT TTCTTCCAGG ATTGCTCTTT CTATCTGCTT TAAACCTCCT 42 0

TGT CAATTG A CTTTCCTTGG CTCCCAACCC ACTTTACTCG AG 4 62

(2) INFORMATION FOR SEQ ID NO: 131:

(i) SEQUENCE CHARACTERISTICS:

<A> LENGTH: 5 35 base pairs
<B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 131:

GAATTCGGCC TTCGTGGCCT ANATATTCTA AG CATTCAAT TTGTCAGTTT CTGAGATTTT 6 0

CTTTCCATCT TAGTTTTTTA GAAGTCAGAA AATGACTTTT CACATTCAGT TAGGGTATAT 120

AACAATGTTA ACGTAAGTTT ATGAGCTGAG TAGGTAGTTA AT AAA CAT C C TTTTAAGTTG 180

TAATGCTTTG AAATAG CAT A TTAAAGGGTT GCAAGGGAAA ATTGGAACAT CAGTGTGAGT 24 0

TATTTTACAG TCATTTGTAG GTCTGTTTGT GACCTTGGCC TTTTCACACT TGTTTGTCTA 300

TCACCTTTAG TATATTACTC TTTGG CACAG GTTGTCTAAT CACATTAATT TTTGCATCAA 3 60

AAATCCCTTG GTTTAGTGAT T CTTAATG AT GTTTATTTTG GAAAGT CATG GACCTGAATT 420

CTTTGAGTAG TTCATGAAAA CCATATACCT TTCCCAGAGA AATGGGGTGC ATATAATTTC 4 80

AGGAAGT TCA AGGTAGGGAA AACAAGCTAA AAATCCCAAC TTATTTCATC TCGAG 53 5

(2) INFORMATION FOR SEQ ID NO: 132:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 01 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 132:

GAATTCGGCC TTCATGGCCT AAGGGGATCA TCAAAGATGT TGGACACCTT GTGTTCAAAT 6 0

CTTGGTTCAG GTGCGGCCTG TGCAGATCGG CTTTTTGGTT TGGTTGTCTT GGCCTGGATA 120

CC AG TGGAG A AGATGT CATC CATATCATCA T CAAAT AT AG ACTTGGTTTC CACTTTCTTT 180

TTGGACTTTT CTTTTGGTTT TACAGT TAAG TCAGCAAAGA TAT CAATGTT ATCATCAAAT 24 0

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AAATTAGATT CCAATGTTTT CTCCTTCTCT CTGGTTTTCT GAGAGGGTTT AATTGCTTCC
G TAG C AAATA TATCATCCTC AAAAATATCT TGTGTTGTTA AT ATGAC AT C CTGCTGACTA
CTGGATTTTG TCTCATTCTT CTTGACTTTC TGATCCTCGA G

300
360
401

(2) INFORMATION FOR SEQ ID NO: 13 3:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 497 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:133:

GAATTCGGCC TTCATGGCCT AGTAGATGAA CTAGAAGATG GATAAACGAA GATAGATAAA 60

ATGAAGAAAA ACAAAAGTCA AGGAGAACTC AGGCGTCCAA GAGTGTGTAA ACAACTTCTG 120

GTGTGAGACG CGCTACATTG CGCTAAATGG CCTGTGCGCT TCTGGTTTTT CCCTTCCTCT 180

GTTGATTTTT TATAGTTGTC TTTTATTTTA AACACGCCTC CCCCCCCCCT TTTTAAACTG 24 0

ATTTTACCAT CACTCTCTCT AGCCCTGCCT CCCTAGAATT AGCTGCTTCT TACCTCCCTT 300

GGATCTGGAA CTTAAATATT AACGTG TATA TAAGTTAATA G TAAGTAG AC CGTGAATTTA 360

GAAGAGTAAA ACAGAATCAT GAGTACGTAG TCACTGTGGC CCCTTTTTTG CTGGATTTCA 420

AGTTCGTAAG CATTTTTGGA AGAGAGTCGA AGGGGAAGGG GTGGCTTGCC AGTCAGTTGA 4 80

GTGATGCATG GCTCGAG 4 97

(2) INFORMATION FOR SEQ ID NO: 134:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 362 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 134:

GAATTCGGCC TTCATGGCCT AGGCTGGTCA TTGAGAGTGT TGGTGCAGTC AAACTGGAAC 60

ACGATGTGAT TGGTAAACAT GTGCTTGATA CAT CG AACAA AATATTCTGT CTCTGCTTCT 12 0

GTAAGTTGAA CAGGCTCAGA AGACTTGAAC AAGGGTCCTA TAT T C AG AAA CTCAGGAATG 1B0

GCAGCCAATT GTTCTTGGGG ATATATTTCT AATGAAGTGC TAGACTATCC AATTACTTAA 24 0

TTTCTTATAC CTTTAGATAA TCAGTATGAA AAGTTCCCAT TTATAATGGA AATGAAAATT 300

CTTAAC TAAA CTATACATGT AATATGTATT TCTAGAAGAG AATAAAAACC CAAGTCCTCG 36 0

AG 362

(2) INFORMATION FOR SEQ ID NO: 13 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 77 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 5:

GAATTCGGCC TTCATGGCCT ACCCCAATCA ATGGATCCTC AACTCCAAAT CCAAAGATAG 60

135

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CATCTTCTGT CACTGCTGGA GTTGCCAGTT CACTCTCAGA AAAAAT AG C C GACAGCATTG

GAAATAACCG GCAAAATGCA CCATTGACTT C CAT TCAAAT TCGTTTTATT CAGAACATGA

TACAGGAAAC GTTGGATGAC TTTAGAGAAG CATGCCATAG GGACATTGTG AATTTGCAAG

TGGAGATGAT TAAACAGTTT CATATGCAAC TGAATGAAAT GCATTCTTTG CTGGAAAGAT

ACTCAGTGAA TGAAGGTTTA GTGGCTGAAA TTGAAAGACT ACGAGAAGAA .AACAAAAGAT
TATGGGCCCA CCTCGAG

120
180
240
300
360
377

(2) INFORMATION FOR SEQ ID NO: 13 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 333 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS : double
(D) TOPOLOGY: linear '

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:136:

GAATTCGGCC TTCATGGCCT AAGCAAAC TT CATG CAGCTG GTGGAACTAG ATGTGT CTCG 60

AAATGAGATT CCTGAAATTC CAGAAAGCAT TTCATTCTGT AAAGCACTGC AGGTAGCTGA 120

CTTCAGCGGA AACCCACTGA CTAGGTTGCC AGAAAGCTTT CCTGAATTAC AGAATTTAAC 180

ATGTCTTTCT GTAAATG A CA TCT CACTACA GTCTCTACCT GAAAATATTG GCAATCTTTA 240

TAACCTGGCT TCACTGGAAC TGAGAGAGAA TCTTCTTACA TATCTT CCTG ACTCTCTTAC 300

CCAGCTGCGA AGACTAGAAG AACTTGACTC GAG 333

(2) INFORMATION FOR SEQ ID NO: 137:

. (i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 09 base pairs
<B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 13 7:

GAATTCGGCC AATGAAGCCT ACTTTAGTAT TTTGG CACTT CCTAATTGAC AC CTTGGGAG 60

ACTG CAGGAA GGGAACGAGA ATCATTNNTA GGNTATTTGT GTGTGTGTGT GGTTTTTTTT 12 0

TTTTTTTGGA AG ACAGAGT C TCACACTTTT GCCCAGGCTG GAGTGCAGTG GCGTGATCTC 180

GGCTCACTGC AACCTCTGCC TCCAGGGTTC AAGCGATTCT CTTGCCTCAG CTTCCCGAGT 24 0

AGCTGGGATT ACAGGCACAC GCCACAACGC CTGG CTAATT TTTATATTTT TAGTAGAGAC 3 00

AGTCTCGAG 30 9

(2) INFORMATION FOR SEQ ID NO: 13 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 599 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 8:

GAATTCGGCC AAAGAGGCCT AAACTCAGAA TGGTGCTACT TGAAGACTCT GGATCTGCTG 60
ACTTCAGAAG ACATTTTGTC AACCTGAGTC CCTTCACCAT TACTGTGGTC TTACTTCTCA 120

136

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GTGCCTGTTT TGTCACCAGT TCTCTTGGAG GAACAGACAA GGAGCTGAGG CTAGTGGATG 180

GTGAAAACAA GTGTAGCGGG AGAG TGGAAG TGAAAGTCCA GGAGGAGTGG GGAACGGTGT 240

GTAATAATGG CTGGAGCATG GAAGCGGTCT CTGTGATTTG TAACCAGCTG GGATGTCCAA 3 00

CTGCTATCAA AGCCCCTGGA TGGGCTAATT CCAGTGCAGG TTCTGGACGC ATTTGGATGG 360

ATCATGTTTC TTGTCGTGGG AATGAGTCAG CTCTTTGGGA TTGCAAACAT GATGGATGGG 4 20

GAAAGCATTA TTG CAATCAC AATGAAGATG CTGGCGTGAC ATGTTCTGAT GGATCAGATC 4 80

TGGAGCTAAG ACTTAGAGGT GGAGGCAGCC GCTGTGCTGG GACAGTTGAG GTGGAGATTC 54 0

AGAGACTGTT AGGGAAGGTG TGTGACAGAG GCTGGGGACT GAAAGAAGCT GAACTCGAG 5 99

(2) INFORMATION FOR SEQ ID NO: 13 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 541 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 9:

GAATTCGGCC TTCATGGCCT AACCTTCCTG AATATCTGCC GTTTGTCCTG CAAGAAATAA 6 0

CTAGTCAACC CAAAAGGCAG TATCTTTTAC TTCATTCCTT GAAGGAAATT ATTAGCTCTG 12 0

CATCAGTGGT GGGCCTTAAA CCATATGTTG AAAACATCTG GGCCTTATTA CTAAAGCACT 180

GTGAGTGTGC AGAGGAAGGA ACCAGAAATG TTGTTGCTGA ATGTCTAGGA AAACT CACTC 24 0

TAATTGATCC AGAAACT CTC CTTCCACGGC TTAAGGGGTA CTTGATATCA GGCTCATCAT 300

ATGCCCGAAG CTCAGTGGTT ACGG CTGTG A AATTTACAAT TTCTGACCAT CCACAACCTA 360

TTGATCCACT GTTAAAGAAC TGCATAGGTG ATTTCCTAAA AACTTTGGAA GACCCAGATT 420

TGAATGTGAG AAGAGTAGCC TTGGTCACAT TTAATTCAGC AG CACAT AAC AAGCCATCAT 480

TAATAAGGGA T CTATTGG AT ACTGTTCTTC CACATCTTTA CAATGAAACA AAAGTCTCGA 54 0

G 541

(2) INFORMATION FOR SEQ ID NO: 140:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 03 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:140:

CTTCATGGCC TAGTGGTTCT TCTGAAATCG GCCTTCAGAC ACCTGTCTTT GGTAGTACCA 6 0

ATATCTAAGA AGTGGTTTCA GTTCAATTTT GTTTTCCTCC ATGCCAGAGA GAAGCCACAG 12 0

TTTCCTAAGC TGGGGAGGAG GTATATCCTT CAAGAGATCG GCTTGTTAGA ATAGACCACT 180

TAACAC C ATA TGAAAAAGCA ACAGACTGAA ACATGGATGT CCTCAAGAAG GGCTG CTGAC 24 0

ACCTATGATT TGGCAAGGAG ATAAATAACA GAATGTGCAA AGGGTCATAA GAGTGCAGAC 300

AC C CTAATG T CTGTTGGCTG GAAGGTCAGA GCAGTTCACC AGTGAAAATG GGTACGCCAT 360

GAAGGCCGGC CTTCATGGCC TATAGGCCAT GAAGGCCGAA TTC 4 03

(2) INFORMATION FOR SEQ ID NO: 141:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

137

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 141:

GAATTCGGCC TTCATGGCCT AGTCCTCATC TGCTGGCATT TTGTGGGGTG TTAGTGCCAA 60

ACTTGAATAG GGGCTGGGGT GCTGTCTTCC ACTGACACCC AAATCCAGAA TCCCTGGTCT 120

TGAGTCCCCA GAACTTTGCC TCTTGACTGT CCCTTCTCTT CCTACCTCCA TCCATGGAAA 180

ATTAGTTATT TTCTGATCCT TTCCCCTGCC TGGTCTAGCT CCTCTCCAAA CAGCCATGCC 24 0

CTCCAAATGC TAGAGACCTG GGCCCTGAAC C CTGTAGAC A GATGCCCTCA GAATTGGGGC 3 00

ATGGGAGGGG GGCTGGGGGA CCCCATGATT CAGCCACGGA CTCCAATGCC CAGCTCCTCT 3 60

CCCCAAAACA ATCCCGACAA TCCCTTATCC CTACCCCAAC CCTTTGCGGC TCTGTACACA 42 0

TTTTTAAACC TGGCTCGAG 439

(2) INFORMATION FOR SEQ ID NO: 142:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 92 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 142:

GCGATTGAAT TCTAGACCTG TGTGTCTAGC TGTGATGGAA TCTGAAATGA AGTTTGACAA 60

GGAC CATG AT GGACTCATTG AAAATGGAGG CTATGCAGAC CAGACCTATG ATGGATGGGT 120

GACCACAGGC CCCAGTGCTT ACTGTGGAGG GCTGTGGCTG GCAGCTGTGG CTGTGATGGT 180

CCAGATGGCT GCTCTGTGTG GGGCACAGGA CATCCAGGAT AAGTTTTCTT CTATCCTCAG 24 0

CCGGGGC CAA GAAGCCTATG AGAGACTGCT GTGGAATGGC CGCTTACTCG AG 2 92

(2) INFORMATION FOR SEQ ID NO: 143:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 457 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 143:

GAATTCGGCC TTCATGGCCT AGGGAGGCTG AGGTGGGAGG CTCACTGGAG GCCAGGAGTT 60

CGGAACCAGC CTGAG CAACA TAGGGAGACC TCAGCTCTAC AACTGAAAAA AAGATAGCCA 120

GGTGTGTTCA TGGTGGCACC TGTCTGTATT CCAGCCGCTT GGGAGGCTGA GGCAGGAGGT 180

TTGCTTGAGT CCAGGAGTTT GAGGTTGCGG TGAGCTACAC AATGAGCTAT GGTGGCACTA 240

CTACACTCCA GCCTGGGCCA TAGAGTAAGG CCCTGTCTCT AAC TGGAAGT CCAAAGAGGG 3 00

ATCTACTTCC TAGACTATTA ATTTAATAGA T CAATAAATT AATCAAGAAT ATGATTTTTT 360

TCTCATCTTT CTCTGTAGTC ATATTTTATA CAGACTTTTT GTTTAAGTAA TCTCTCTTTA 4 20

TGGGCAGACA ATGATTTCAG ' AAACACCCTG CCTCGAG 4 57

(2) INFORMATION FOR SEQ ID NO: 144:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 88 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

138

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:144:

GAATTCGGCC TTCATGGCCT AGTCAGCCGT GACTGCACCA CCATACTCCA GCCTGGGTGA 6 0

CAGAGCGAGA TCTTGTCTTA AAACAAAACA AAACAAAACC CAGACTTCCT ATAATTCCTA 120

AAAATAAATG TGGGTTTGAG AGGCCTACCT TGAAATGTAC AAGATCCTGG CCAGACTTCA 180

CCTATCTAAC AATATGCTAG TAACTATTTG TTGACATGTC TTAAAGAAAT GTTCATCAGG 240

GCCTCAGAAA GCAAGGCAGA GAACAGGTCC CTGAAATTTA CTAGCTTGCA CCAAACCATC 3 00

AGATAAAGAT AGGTTAATAT TTGACAGAAA AAACTCTTCA AAAAGAGACA G TGAAATACT 3 60

CTTGAGATGA ATCCAGGCGG CTCTCGAG 3 88

(2) INFORMATION FOR SEQ ID NO: 145:

(x) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 03 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 145:

GAATTCGGCC TTCATGGCCT AGG CAGTGG A GGCCTCTGTA ATTCTAGCAT ACAGGTGGCA 60

AGTTATTACA TTATTTCTTT CCTCCTGTCT ACCTGCAGTT GGTTTTATGT GGGGCGTTAG 120

TACACTTCCC AAAGGGCTTG CCCGCAGGTG AGAGGTGCAC ATTGAACTCC CTCACCAGGC 180

AGATGGGAAG TGTGGCCATG AGAGAGAGCT TCAGGGGCCC TGGGTTTATG ACATCGCTGG 24 0

GCCAGGAATG AGGTTAATAT TTTTAATGGC GAAGGGTGAG CCCCGTTATT ACCCGAGCTC 3 00

GAG 3 03

{2} INFORMATION FOR SEQ ID NO: 146:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 76 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 146:

GAATTCGGCC TTCATGGCCT ACTGGATGGC ATCTACTTCG TATGACTATT GCAGAGTGCC 60

CATGGAAGAC GGGGATAAGC GCTGTAAGCT TCTGCTGGGG ATAGGAATTC TGGTGCTCCT 12 0

GATCATCGTG ATTCTGGGGG TGCCCTTGAT TATCTTCACC ATCAAGGCCA ACAGCGAGGC 18 0

CTGCCGGGAC GGCCTTCGGG CAGTGATGGA GTGTCGCAAT GTCACCCATC TCCTGCAACA 24 0

AGAGCTGACC GAGGCCCAGA AGGGCTTTCA GGATGTGGAG GCCCAGGCCG CCACCTGCAA 3 00

CCACACTGTG ATGGCCCTAA TGGCTTCCCT GGATGCAGAG AAGGCCCAAG GACAAAAGAA 360

AGTGGAACAA CTCGAG 3 76

(2) INFORMATION FOR SEQ ID NO: 147:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 412 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

139

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 7:

GAATTCGGCC TTCATGGCCT AATGGAAAGG ACAAGGAAAA GGGAGAAGGG GTGAGAGTCT 6 0

GTCCTAGGGG CCAACGAGAA CAGTGAGCTG TTTCAGGGGA GCCATTTCCT TGTCCATGCT 120

CACAAGCCTG TGGATTCTTC CCCCTCTGCA GGAAATTACC TGATGTTCCA AACCCCCTCC 180

AGATCCTGTA TATCCGCAGC ATCTCCCCTT TCCCTGAGCT GGAACAGTTT CTACAGGACA 24 0

CTATCAAGAG GTACTAGGGG CCTGGAGGTT TGGGCTCCAA GAGAAGCTTG ACAGAGCCCA 3 00

CGCCCGACCC CTACTTCTGT TTCTTCCTAA GGTATAATCT GCAGATGTTG GAAGCTGAGG 360

GCAGCATGAA GCAGGCCCTG GGTGAACTGC AGGCACAGCA GCCCCCCTCG AG 412

(2) INFORMATION FOR SEQ ID NO: 14 8:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:148:

GCCTGGCCAT CCGGAGAGCT AAGAAC CTCA GGCGGCTGCT GTACGTNTCA TGCAACCCCC 6 0

GGGCAGCCAT GGGCAACTTT GTGGACCTCT GCAGAGCCCC ATCTAACCGG GTGAAGGGCA 120

TTCCCTTCCG GCCGGTCAAG GCTGTGG CAG TGGACCTGTT CCCGCAGACC CCTTCTTTTT 180

TCATACTTAT ATGAAAGACT ACATACTTAA AATACTGGTG ATTATATTTA GGACCTGAAA 24 0

TCATAAGATT GTGGTCTTGC TTTTTACTTA TTTTTGTATC TTAGCGATGT CTAGAGTTAA 300

TAAGTGTTGC TTTTCTAATC ACAG CAAATC TCGAG 335

(2) INFORMATION FOR SEQ ID NO: 14 9:

(i) SEQUENCE CHARACTERISTICS ;

(A) LENGTH: 4 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 9:

GGATTCGGCC TTCATGGCCT AGTGGGGCAC TAGGATCATC ATTTGGGTGA GAGCCCTCGG 60

CAATGGTGGA GAGGGAGAAG TTATCATTGT GGAGCTCAGA TGGGGTCCGG AATTTGTTGG 120

TCCTACGCAG CTTGGTATTC TCCGTCTTGA G CAGGTAG AG CTTCTTGGCA AAGAACACCG 180

TCATCATGAA GAGCAGGAGC AGGACGAGGG CAGCCGAGCC CACGGCCACG CACATCACCT 24 0

GGAAGTCGGT GATGATGGAC TCGCAGCGCA TCCCCTTGTG CCAGATGTAG TCCTGCGTGT 3 00

TGCACCTGCA GAAGGCCCCT ATGTTCTCCA CCAGGTAGCA CTGGCCGCCA TTGTGACAGT 360

AACTTGGGAA GAGGTCG CAC ACTGACCGGC AGGAGCCGTT ATGCCGCACA AAGCCACTGC 420

GGCACTCAGT GCCATTTTCA CTGGAGG CCA AGTCCCTGCC TGGCTCTCCT TAGGCCATGA 4 80

AG 4 82

(2) INFORMATION FOR SEQ ID NO: 150:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 277 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

140

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(D) TOPOLOGY: linear
(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 150:

GTTCCTTACT AACTTTAATG GCCACAACAT TTAGGCGAAA GGGGGGCAAT CATTGGTGGT 60

TTGGCATTCG CAGAGACTTC TGTCAGTTTC TGCTTGAAAT TTTCCCATTT TTAAGAGAAT 120

ATGGGAACAT TTCATATGAT CTCCATCACG AAGATAGTGA AGATGCTGAA GAAACATCAG 18 0

TTCCAGAAGC TCCGAAAATT GCTCCAATAT TTGGAAAGAA GGCCAGAGTA GTTATAACCC 240

AGAGCCCTGG GAAATACGTT CCCCCCCTCT CCTCGAG 277

(2) INFORMATION FOR SEQ ID NO: 151:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 272 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 151:

GCTCGCCCAC TTTATGAAGA GCGATTTCAC GGCTGCTTGA ACCATTCGAA TTTGGATTTG 6 0

TGTTCAGCAC TTTAAAAGGT TCAACTTTTT GCTTCTACCC AG ATTGGT CT CAGGTCTGTC 120

TTCTCCAGAT GACCGGTGGT TTCCTGAGCT GCATCTTGGG CTTGGTGCTG CCCCTGGCCT 180

ATGGCTTCCA -GCCTGACCTG GTGCTGGTGG CGCTGGGGCC TGGCCATGGC CTGCAGGGCC 24 0

CCCACGCTGC ACTCCTGGCT ACAATACT CG AG 272

(2) INFORMATION FOR SEQ ID NO: 152:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 152:

GAATTCGGCC TTCATGGCCT AGGGGCGGTG AAACGTCCTG AAGAGCGTCC AGCTCGTGGC 60

CGAGAGGACT CGGGCGCTCC CCACG CTGG A GGCCGTGGAC CGCTCCCTTT AAAAGTTGAA 120

ACGGCCGCCG TTCGGGACGG CCTGGCGGGA GGAGGGCCCG ACGAGGGGAG GCTTCAGGGA 180

CAACTGGGGC TTCTCGACGT CCACCCTTTT CAGGGCGCGG CCCCGGTAGC CCTCGGGCCG 240

GCCCAGGTAC AGGAGGTGCT TCCCGGGACC CCCGGAGTAC CTGGAGGGAC CTCCCGAGGG 3 00

GACTCGAG 3 08

(2) INFORMATION FOR SEQ ID NO: 153:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 8 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

141

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(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 153:

GAATTCGGCC TTCATGGCCT ACAATCCCAA ATGTAGGATC ATGCCCATTG CCCTAAGCCC 60

AGGCATGAGA GTCGACATCT CTCCTCTTAT ATACAGATCC AGTCCACAGG TGAAGTGGGA 12 0

ACTCTCCAAC CAGGATT CAG CACACCATTG ATGTTGCGAC TCCTCTACTG GAACACAGCT 18 0

TGGAGAAGGG ATTGGGGCTC TCATGGCAGG ATGCAATCCA CTGTTGAGAT TGTGACTCAT 24 0

GCACTTGAAC CTAAGTCTCA GGAGTTGTTG ACTCTTACAC CCAGCACCCA GGTGATAGGA 3 00

CTCTCATGTC TGGTTCCTGC CCACAGGTGA AATTGTGACA TATACATGGT CACAGCTCAC 36 0

AGGTGAGGTG ATAACTCACA TACCTGGATC CAGCTAAGAG AACAGATTTT GACTCTGATA 42 0

TCTTAGGCCA TGAAGGCC 43 8

(2) INFORMATION FOR SEQ ID NO:154:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID N0:154:

GAATTCGGCT TCATGGCCTA CAAGATGACT AAAGTCTTCA CTCACCAAGG AAAAGTGGCT 6 0

CTGTATGGCA AGCTGGTGCA GTCAGCTCAG AATGAGAGGG AGAAACTTCA AATAAAGATA 120

GATGAGATGG ATAAAATACT TAAGAAGATC GAT AACTG CC TCACTGAGAT GGAAACAGAA 18 0

ACTAAGAATT TGGAGGATGA AGAGAAAAAC AATCCTGTGG AAGAATGGGA TTCTGAAATG 24 0

AGAG CTGCAG AAAAAGAATT GGAACAGCTG AAAAC TGAAG AGGAGGATGC TCTCGAG 297

(2) INFORMATION FOR SEQ ID NO: 155:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 95 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 155:

GAATTCGGCC TTCATGGCCT AAATTTAGGA AGGTCAAACG TGAATCTCCA TTTGACAAAC 60

GTCCAACTGC AG CAG AG ATT AAAGTGGAAC CCACCACTGA GTCATTGGAC AAAGAGGGCA 120

AAGGTGAAAT TAGAAGCCTA GTGGAGCCAC TCAGTATGAT C C AATTTG AT GATACTGCTG 18 0

AGCCACAGAA AGGAAAAATA AAAGGAAAGA AACACCATAT CTCTTCAGGA ACTATCACAA 24 0

GCAAAGAAGA AAAAACTGAA GAGAAGGAAG AGTTGACCAN ACAAGTCAAG TCTCATCAAC 3 00

TTGTTAAATC ACTCTCAAGA GTGGCTAAAG AGACTTCAGA AT C T ACCAGA GTTCTAGAAA 36 0

GTCCAGATGG CAAAAGTGAA CAG CGTAACC TCGAG 3 95

(2) INFORMATION FOR SEQ ID NO: 156:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 422 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 156:

GAATTCGGCC TTCATGGCCT ACAGAGTACT GAGTGGAACA TACGATGATA G ATT T AC AAA 6 0

TAATGTAGCA TACTTCTACT TCATTGTATC TTAAGTTTCT TGAAATATTG CTACTGGAGA 12 0

TTGGAAAGAA ATCTTAATGT TATGGGGTAT TGTCTAAGAA GCTTTATTTT AAAACCATCT 180

CATTAAATTT TGTTGCATTT TAGATAATCG TCCCCAGATG CCATGTTACC CTAGTG CAGA 240

GTTTGGGGCT GGATAAGTTT TTGTTGTAGG TGGCTATCCT GTGTTTTGTA G GGTATTT AG 30 0

CAGCATCCTG GCCTTAAAAC AAAAATGTTT TCAGACATTG CCAAATGTCC CCCGAGCGGT 360

AAAGTCACCC CCAAGTTGAG AACCGCTCTA TACAAAGAGC TG TTATTAG A GCCAGACTCG 42 0

AG 422

(2) INFORMATION FOR SEQ ID NO: 157:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 92 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY.: linear

<ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 157:

GAATTCGGCC TTCATGGCCT AGATTGCTTG AGGC CAGAAG TT CAAGAC AG GCTGCCCAAC 6 0

ATAGTGAGAC CCCCTTCTCT ACCAAAATTT TAAAAATGAG CATGCAT CTG TAG TCCT AGC 120

TATTGGGAAG GCTGAGGCAG GAGG AT CATC TGAGCCCAGG AGTTTGAGGC TGCAGTGAGC 180

TAAGAAGGTG CCACTGCACT GCTGTTGTCT CTCAG CAGAT CATTTTCAGC TTTCTTTGGA 24 0

GAGTAGCCAT TAG CAATGCA AATGTGAAGT TTGATAGCAC AATAAATAAA ACACTGAAAA 300

CTGTAGATGT TACTTATAAA ACACTGGCAC TCAGATAAAT TGGGTTTGGT CAAGAAGACA 36 0

GTGAAGCATA TCCCTGTTGG GCCAGAGGCT GTTATCGTTT TGCTCTGAAT TCAAAACCTG 42 0

ATATGTCTCC AAATTTGCTT AGGGT TGTTA TCCTGGAAAA TAGAAT CTGA TAGAAGGTGG 4 80
GCACATCTCG AG "492

(2) INFORMATION FOR SEQ ID NO: 158:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 505 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15 8:

GAATTCGGCC TTCATGGCCT ACTGCTTTCG TGAAGACAAG ATGAAGTTCA CAATTGTCTT 6 0

TGCTGGACTT CTTGGAGTCT TTCTAGCTCC TGCCCTAGCT AACTATAATA T CAACGT CAA 12 0

TGATGACAAC AACAATGCTG GAAGTGGGCA GCAGTCAGTG AGTGTCAACA ATGAACACAA 18 0

TGTGGCCAAT GTTGACAATA ACAACGGATG GGACTCCTGG AATTCCATCT GGGATTATGG 24 0

AAATGGCTTT GCTGCAACCA GACTCTTTCA AAAGAAGACA TGCATTGTGC ACAAAATGAA 30 0

CAAGGAAGTC ATGCCCTCCA TTCAATCCCT TGATGCACTG G T CAAGG AAA AG AAG CTTCA 36 0

GGGTAAGGGA CCAGGAGGAC CACCTCCCAA GGGCCTGATG TACTCAGTCA ACCCAAACAA 420

AGTCGATGAC CTGAGCAAGT TCGGAAAAAA CATTGCAAAC ATGTGTCGTG GGATTCCAAC 4 80

ATACATGGCT CAGGAGATGC TCGAG 505

(2) INFORMATION FOR SEQ ID NO: 159:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 373 base pairs

143

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(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 159:

GAATTCGGCC AAAGAGGCCT AGCCGGAGCA GCTGTCTGGG AGTCAAGGCT GCAGTAGCGT 6 0

TTCTTCATGG GGTGCTCCAG GGGGTGCCAC AGACCGACAG GCAGCCCAAG GGCCTGGACA 12 0

CCCCTCCCCA GGCAGGTGCT GCCCCAGGAG GACTGTCCTC GGGAATGAAC CTCCCGCGGG 180

CTTTGGACTG AGGTCCCTGT GGCCTCGGTC TCCTCCCCAT GAAG TGGGAG CGAGGCTCCC 24 0

CAATGGTGCT TTTGGCTTTA GTGTACGATG TTTGCTGTGC TTCCCGCCGT GGAGGGCAGA 3 00

GCCACCCCAC ATCAGGATCG GACGTGCTAC CCCTCCCGGT CCCGGCCCTG GCCCAGCCAG 3 60

CCCAGCCCTC GAG 3 73

(2) INFORMATION FOR SEQ ID NO; 160:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 362 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 160:

GAATTCGGCA AAGAGGCCTA ATGAATTCTC TGATCACAAA ACAGACCCAG GAAAGCATTC 6 0

AGCATTT TG A GCGACAGGCA GGGCTGAGAG ATGCTGGCTA CACACCCCAC AAGGGCCTCA 120

CCACCGAGGA GAC CAAGTAC CTTCGAGTGG CCGAAGCACT CCACAAACTA AAGTTACAGA 180

GTGGAGAGGT AACAAAAGAA GAGAGGCAGC CTGCATCAGC CCAGTCCACC CCAAGCACCA 24 0

CTCCGCACTC TTCACCTAAG CAGAGG C CCA GGGGCTGGTT CACTT CTGGT TCTTCCACAG 300

CCTTACCTGG CCCAAATCCT AGCACCATGG ACT CTGGAAG TGGGGATAAG GACGGGCTCG 360

AG 362

(2) INFORMATION FOR SEQ ID NO: 161:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 419 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 161:

GAATTCGGCC AAAGAGGCCT AGTTTTACAA AACGCG AT TT GTAATATAAA CTAGTTAGAT 60

AACTCAGAGG GTTTTATTGG CCATATTTTT GTTTATGCTT TGTCACAGGC TTTAGTCATT 120

GCTTCCATGT GTTTTCATCC TTCAGGATAT CTTCAAGAAG CCTACTTATG GACCAAACAA 1B0

GTTCTGACCA TCATGGAGAA ATCTCTGGTC TTGCTCAGGG AGGTGACGGA TGGCTCCCTC 24 0

TATGAAGGAG TTGCGTATGG CAGCTACACC ACTAGATCAC TCTTCCAATA CATGTTTCTC 3 00

GTCCAGAGGC ACTTCAACAT CAACCACTTT GGCCATCCGT GGCTTAAACA ACAC TTTGCA 360

TTTATGTATA GAACCATCCT GCCAGGTATA GTGAGGAGTC AGAAGTGTGA AAACTCGAG 419

(2) INFORMATION FOR SEQ ID NO: 162:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 261 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16 2:

GAATTCGGCC AAAGAGGCCT ACAGGTAGTA TCTTTATAGC GGTATAAAAA CAGACTAATA 60

CAAACAGGTA GCTCTAAATT GTGAGTTTTT CTTAACTCCT TTGATCTTCT GTGATAGCGA 120

TTTTTCACAT TTCACACTTC CCTAATGCCA AAAATCCACC TCCAGCAGCT GTTTTGCCTC 180

TTTCTTATCC TGCCCCTTGG AAGAATGTCA TCATTATTGC TGCCACAGCA CTGTGTTCTT 240

TTTCAGAAGT TACAGCTCGA G 261

(2) INFORMATION FOR SEQ ID NO: 163:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 10 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:163:

GAATTCGGCC AAAGAGGCCT AGTGGTCTGG GGCAAAATTT AGTAAGACCT GGAAAG CATA 60
GGTAATCAAA GCAGAAACTG ACAAATGAGA TGGTATCAAG CTAAAAAG 108

(2) INFORMATION FOR SEQ ID NO: 164:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 164:

GAATTCGGCC AAAGAGGCCT AGTTTAACCT CATCAGACAT TATTGCAGCC AGCTGTCAGC 6 0

CAAGCTCAGT AACCTTCCAA CGCTCATTTC CATGAGGCTA GAGTTCC1GA GAATCCTCTG 120

TAGCCATGAG CATTACCTCA ATCTGAACCT TTTTTTTATG AATG CTGATA CTGCTCCAAC 1B0

ATCTCCTTGT CCTTCCATAT CTTCCCAGAA CTCAAGCTCC TGCTCCAGCT TCCAGGACCA 240

GAAGATCGCC AGCATGTTCG ATCTGACTTC CG AGTACCG C CAGCCCCTCG AG 292

(2) INFORMATION FOR SEQ ID NO: 165:

{ i ) S E QUENCE CHARACTER ISTICS :

(A) LENGTH: 13 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16 5:

145

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GAATTCGGCC AAAGAGGCCT AG C AAAAACT GTTCAAAAGA GTTGTTGATT ACTTTCATTT 50
CCACTTTCTC ACCCCCATTC TCCCCTCAAT TAACTCTCCT TCATCCCCAT GATGCCATTA 12 0

TGTGGATTCC TCGAG 13 5

(2) INFORMATION FOR SEQ ID NO: 16 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 449 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16 6:

GAATTCGGCC AAAGAGGCCT AGAAAAAGTA GCACAGTGGA GTCTGAAATA GCAAGCGAAG 6 0

AG AAAAG CAG AGCTGCTGAG AGGAAAAGGA TTATTATTAA GATGGAGCCA GAAGATATTC 12 0

CTACAGATGA ACTGAAAGAC TTTAACATTA TTAAAGTTAC TGATAAAGAC TGTAATGAAT 180

CCACTGACAA TGATGAATTA GAAGATGAAC CTGAAGAGCC ATTTTATAGA TACTATGTTG 240

AAGAAGATGT CAGCATAAAA AAAAG TGGTA GGAAAACTCT AAAACCTCGA ATGTCAGTAA 3 00

GTGCTGATGA AAGAGGTGGT TTAGAGAATA TGAGGCCCCC TAACAAC AG C AGTCCAGTAC 3 60

AAGAGGATGC TGAAAATGCA TCTTGTGAGC TGTGTGGACT TACAATAACC GAGGAGGACC 420

TGTCATCTCA TTACTTAGCC AAACTCGAG 44 9

(2) INFORMATION FOR SEQ ID NO: 167:

(i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 565 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:167:

GAATTCGGCC AAAGAGGCCT AAAAGGAAAC TTGGACAAGT AGAAAGTGGA TGACCCAGGC 6 0

TCCGTTACAT ATACTTGGAT TCCAGCTGGG AC CTAGATTT GCTGAGGACG GAAGCCAAGG 120

AGACAGGAAC ATGTGGCTGC TCCCAGCTCT ACTCCTTCTC TGCCTCTCAG GCTGTTTGTC 180

TCTGAACGGC CCCGGCTCTG TGACTGGCAC TGCGGGGGAC TCTCTGACAG TGTGGTGTCA 24 0

GTATGAGAGC ATGTACAAGG GATATAACAA GTACTGGTGC CGAGGACAGT ACGACACGTC 3 00

ATGTGAGAGC ATTGTGGAGA CCAAGGGAGA AGAGAAGGTG GAGAGGAATG GCCGCGTGTC 3 60

CATCAGAGAC CACCCGGAGG CTCTCGCCTT CACTGTGACC ATGCAGAACC TCAATGAAGA 420

TGATGCTGGA TCTTACTGGT GCAAAATTCA GACAGTGTGG GTCCTGGATT CATGGTCACG 4 80

CGATCCCTCG GACCTGGTTA GGGTGTATGT TTCCCCAGCA ATTACAACCC CAAGGAGGAC 54 0

CACACATCCA GCCACCCCGC TCGAG 565

(2) INFORMATION FOR SEQ ID NO: 16 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 158 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16 8:

146

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GAATTCGGCC AAAGAGGCCT AGTTTCCTTT ATATGTTTGC ACTTAATTTG ATTCCATCCT 60
TCATGCTGTT TTCATTATTC TTAGTTCATC TACACCACAT AAATTATCAC CTTTGTTTTC 120
AGTTCCCCAA TTTCCATGTG CCACAAACAA ATCTCGAG 15 8

(2) INFORMATION FOR SEQ ID NO: 16 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 83 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 169:

GAATTCGGCC AAAGAGGCCT AGTCTCACCA T CTAT TCTAA ACCTTATATT ATCAATCCTA 60

TTCCCTCTCA CCAAAAGAAT CCCTTTATAC AAGTAATTAT CCTGTCTATG TCTTT CAACT 12 0

CTAGTTTCCC CACTGCAACT CTTCCCTTAA TATATGTACC TGCTCTGTTA TCCCTCTCCA 180

GCTACTTCCC TATTTTCTGT TCCCCTTTAC AGGAAAACTT TTCTCCAGCA TTTCCCAATG 24 0

CCATTGTCTT ACTTCCTCAC ATTCTATTTT CTTCTCAAAC CATTTTTATT AGGCTTCTTT 3 00

CCCCAATGGC TATTGTCAAG CTTCACTTAA TGCCGTGCAA ATCACCCTAT TCTCCAGGTC 3 60

TTCTTTCTTC CCAGTCTCTC GAG 3 83

(2) INFORMATION FOR SEQ ID NO: 170:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 282 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 170:

GAATTCGGCC AAAGAGGCCT AAATATTGTC TGAAAAAAAT ATATGAGACC CATTACTCAG 60

TCTCTCCTCC TGCCATTTAT ACTGCAGGTA TTCCCCAAGT TTCTCTTCTC AACCTTTGCC 120

TCCTTTTCCC TGCTTGCTCC CTTAGTTTTC TCCTCTGGGT GGATGACTCC CAAATCTAGC 180

ACTGACCTGT TTGTCCACAT CCTTGAGTAT CCCACCACCA TTTCACACCC AGCATATCCA 24 0

GATGGAGCTC TTATCAGTTG TAACAGCACT GCTCAATTCG AG 282

(2) INFORMATION FOR SEQ ID NO: 171;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 3 50 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 171:

GAATTCGGCC AAAGAGGCCT AGTGGAAGAG AAGAATGTTT CTGTCTCTTC CTACGTTGAC 60

TGTTCTTATT CCACTGGTTT CTTTAGCAGG ACTGTTCTAC TCAGCCTCTG TGGAAGAAAA 120

CTTCCCACAG GGCTGCACTA GCACAGCCAG CCTTTGCTTT TACAGCCTGC TCTTGCCTAT 180

TACCATACCA GTGTATGTAT TCTTCCACCT TTGGACTTGG ATGGGTATTA AACTCTTCAG 24 0

147

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GCATAATTGA TGCAACTAGA GTCAATATGC TGTATATATT AATGATAGCT CTTGGGCATC
GATCTCTGAA AGCTCAAATG GATGGAATTT AGTTTGCGGG AACTCTCGAG

300
350

(2) INFORMATION FOR SEQ ID NO: 172:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

( D ) TOPOLOGY : 1 inea r

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 172:

GAATTCGGCC AAAGAGGCCT AGGGGTGTAC ATTTTATTGG AAACCTTAAA TACTG TTCAG 6 0

AAAGAATATA TCTTCAATCA AGGCTCTTGT GCAGCCTACA CAGAAAAATG AAGCTTTTTG 12 0

GGTTAGGTGC AACGCTCGAG 140

(2) INFORMATION FOR SEQ ID NO:173:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 173:

GTGGTCTCTC CTCCCCTGCC ACTCCCCTCT TCTTTTTTTT CCAACATGGC CTTGCTCCGC 6 0

GTACATCGCC ACCCAGGGAC CGCTGCCCGC CACCGTGGCT GACTTTTGGC AGATGGTGTG 120

GGAGAGCGGC TGCGTGGTGA TCGTCATGCT GACACCCCTC GCGGAGAACG GCGTCCGGCA 1B0

GTGCTACCAC TACTGGCCGG ATGAAGGCTC CAATCTCTAC CACATCTATG AGGTGAACCT 24 0

GGTCTCCGAG CACATCTGGT GTGAGGACTT CCTGGTGAGG AGCTTCTATC TGAAGAACCT 3 00

CGAG 3 04

(2) INFORMATION FOR SEQ ID NO: 174:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 174:

GCGATTGAAT TCTAGACCTG CCTCTCTTAT ACCTCGGTGT GGCCGAAAGG AAATAAGCAG 60

AGGCGCTATT GGCAGGACCT AGAAACTTTC CTTGTAACAT AGCTAGTATG TTCCCTCTGC 120

CCCTTCTTCA TCTTTTCCTC ACACTTGCTG GAG CTGGAGC AGCTATCCTG ACCGCAGGTG 180

CACTCGAG 18 8

(2) INFORMATION FOR SEQ ID NO:175:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 274 base pairs

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<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 175:

GAATTCGGCC TTCATGGCCT ACTATCTGCC TTGCGCTCCC ACTGCCCTGA CCTGTGCCCT 60

CTCACAGGCC CCCGTGATGG CTCGCTGGCC TCCCTTCGGC CTCTGCCTCC TCCTGCTGCT 120

GCTGTCCCCA CCGCCACTGC CCTTGACAGG GGCCCATCGC TTCTCCGCAC CTAATACCAC 180

TCTCAACCAC TTGGCACTGG CACCTGGCCG AGG CACACTC TATGTCGGCG CAGTGAACCG 240

CCTCTTCCAG CTCAGCCCCG AGCTGCAGCT CGAG 2 74

(2) INFORMATION FOR SEQ ID NO: 176:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 27 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 176:

GGTCAGCCGA GCATGATAGG AGACATCATC AACCTCGGCC TGAAAGGGAG GGAGGGGAGA 60

GCAAAGGTCG TCAACGTGGA GATCGTGGAG GAGCCCGTGA GTTATGT CAG CGGGGAGAAG 120

CCGGAGGAGT TTTCCGTCCC ATT CAAAGTG GAGGAGGTCG AAGATGTGTC GCCAGGCCCC 180

TGGGGGTTGG TTAAGGAGGA GGAAGGTTAT G GAGAAAGCG ATGTCACATT CTCAGTTAAT 24 0

CAGCATCGAA GGACCAAGCA GCCT CAGGAG AACACGACTC ACGTGGAAGA AGTGACAGAG 300

GCAGGTGATT CAGTGGG CG A GCTCGAG 3 27

(2) INFORMATION FOR SEQ ID NO: 177:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 B base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 177:

GAATTCGGCC
GCTGCTGCCT
TCAAGTCCAC
CTCCCCAAGT
TTCCTGGATG
GTTGCCTTTG
AGTGTGCCCT

AAAGAGGCCT AAG CAATGTC TCCACCACTG CTGCTGCTAC CCTTGCTGCT
CTGCTGAATG TGGAGCCTGC TGG GGCCACA CTGATCCGGA TCCCTCTTCG
CCTGGACGCA GGACCCTGAA CTACTGAGGG GATGGGGAAA ACCAGCAGAG
TGGGGGCCCC ATCCCCTGGG GACAAGCCTG CCTCGGTACC TCTCTCCAAA
CCCAGTATTT TGGGGAAATT GGGCTGGGAA CGCCTCCACA AAACTTCACT
ACACTGGCTC CTCCAATCTC TGGGTCCCGT CCAGGAGATG CCACTTCTTC
GCTGGTTCCA CCACCGCTTC AATCCCAATG TCCTCGAG

60
120
1B0
240
300
360
408

(2) INFORMATION FOR SEQ ID NO:178:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 05 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

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(D) TOPOLOGY: linear
(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17 8:

GAATTCGGCC AAAGAGGCCT AGGAGGAATT TCCATCTTGC TCTCAAAGTG AGTCTGAATG 6 0

TGCTCGGTGG TGTCACCCCC GCCGAGCTGC CAGTGCAGAA GGCCACTATT GAACTCCTGC 12 0

ACACGCCCCA ACTTGTCAGA TCGGTCAACA ACAAACAGGT TGTTCTTTTT GACTATCTTT 18 0

ATTGGCAGCT TGTCGAACTT ACTGGCTTGC TTGGGCTTCT CCTTTGGGTC TGCAGCGGCG 24 0

TCCGGGGCAG TCAGAGCGAT GCTGCTCTTT TCATCGCTTT CTGTCTTCTC GCTGTCTACC 3 00

TCGAG 30 5

(2) INFORMATION FOR SEQ ID NO: 179:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 247 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:179:

GAATTCGGCC AAAGAGGCCT AGTGCAG CAA TTTAGAGAGT GTCTCAGGAG TGTGGCT CAC 60

TGGCAGCTGC AG CTATGTTA GTGCTTCTTT CTGCCTCAAG TTCAGAAACA AGCTGGACTA 120

TCTCAGGGTG ATTGAATTTT CCTGCTGTGG AATCATAGAA GTCTTGCAGT CTCCCAGGTT 180

TGTGTTCAAG GTCTTCATAT TCAGATG CTT GAAGAATCAT TTCACATTGG TCTAGCATTC 24 0

AATCGAG 247

{2) INFORMATION FOR SEQ ID NO: 180:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 180:

GAATTCGGCC AAAGAGGCCT AGTCAAGTTC ATTTCCCAGA GTCTTAAGAC TAAGTTCTGC 6 0

CTCCTCATTG CAGGTGTGCC GAG AGTTT TT TTTGAACAAC AAAAATTACT AAGGAACCTC 12 0

ACTACCTTTG GCGGTAGAAT TAGAAAACAG ATTCAGCAGT CACCTACTCC CCTTCAGTAA 180

TTCGAGACAA TTATTTTTCT CCTGACACAA CATCAGGTCC CATGAAAAAT GACACCGTGC 240

CTGGTGTTTT TGGGTTCTTT AATGCTTCTT TTAGAGCCAC ATTTTTCTTT TCAAACCGAG 3 00

TTCCCATCGC TCGAG 315

(2> INFORMATION FOR SEQ ID NO: 181.:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 328 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

150

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 181;

GAATTCGGCC AAAGAGGCCT AATTTTTCTT CACGTTCTTT ATCACCACCA TGGTTATGTT 6 0

GGCTGCCCTG GCTCACCATT TGTTTTACTG GGATGTTTGG TTTATATATA ATGTGTGTTT 120

AG CT AAGGTA AAAGG CTACA GGTCTCTTTC CACATCCCAA ACTTTCTATG ATGCTTACAT 180

TTCTTATGAC ACC AAAGATG CCTCTGTTAC TGACTGGGTG ATAAATGAGC TGCGCTACCA 240

CCTTGAAGAG AG CCGAG ACA AAAACGTTCT CCTTTGTCTA GAGGAGAGGG ATTGGGACCC 3 00

GGGATTGGCC ATCATCGACA ACCTCGAG 32 8

{2} INFORMATION FOR SEQ ID NO: 182:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 123 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 18 2:

GAATTCGGCC AAAGAGGCCT AGTTGTGGAA AAGAAAGACT GTGAGGGTAG GCACAAGAGC
ACTCAAATGT CCCAGGTAGA GAAAACAACA TGTATGATGG CCCAGAAGGA GGCAAGTCTC
GAG

(2) INFORMATION FOR SEQ ID NO:183:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 311 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 183:

GAATTCGGCC AAAGAGGCCT ACTTGGACAA GTAGAAAGTG GATGACCCAG GCTCCGTTAC 60

ATATACTTGG ATTCCAGCTG GG AC CTAGAT TTGCTGAGGA CGGAAGCCAA GGACACAGGA 120

ACATGTGGCT GCTCCCAGCT CTACTCCTTC TCTGCCTCTC AGGCTGTTTG TCTCTGAAGG 180

GCCCCGGCTC TGTGACTGGC ACTGCGGGGG ACT CT CTGAC AGTGTGGTGT CAGTATGAGA 24 0

GCATGTACAA GGGATATAAC AAGTACTGGT G CCGAGG AC A GTACGACACG TCATGTGAGA 3 00

GCTCACTCGA G 311

(2) INFORMATION FOR SEQ ID NO:184:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 184:

60
120
123

GAATTCGGCC AAAGAGGCCT AGTTCAATCT GTAACAAG C C TTCTTCAATT TCCTCTCCAC 60
ATACCCTGCA TAGACTTTAA GATTCCTCTG CTCGATGCTA ATAAGAAGAC ACACACCCCT 120

151

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CGTTCTCGAG 13 0

(2) INFORMATION FOR SEQ ID NO: 185:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 416 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 185:

GAATTCGGCC AAAGAGGCCT AGGAGGGGGA AGAGAGTCCG TTTTGCAGAA GATGAAGAAA 60

AGAGTGAAAA TTCCTCGGAG GACGGTGACA TAACGGATAA GAGTCTTTGT GGAAGTGGTG 120

AAAAGTACAT CCCACCTCAT GTGAGGCAAG CTGAGGAGAC AGTGGACTTC AAGAAAAAGG 180

AAGAACTAGA AAGCTTGAAG AAACATGTAA AAGGTCTACT TAACAGGTTG AGTGAACCCA 240

ACATGGCTTC CATCAGTGGG CAG CTGGAGG AACTGTACAT GGCCCACAGC AGAAAGGACA 3 00

TGAATGACAC CCTGACCTCC GCTCTCATGG GTGCCTGCGT CACTGCCTCG GCCATGCCCA 3 60

GC AG AC TGAT G ATGG AG CAT GTTCTCTTAG TCAGCATCCT TCACCACTTA CTCGAG 416

(2) INFORMATION FOR SEQ ID NO: 186:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 344 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 186:

GAATTCGGCC AAAGAGGCCT ACTACATTTT TACCTAAATT TATAGAAAAT CAATTCGGAT 60

TGACATCCAG CTTCGCAGCT ACTCTTGGAG GGGCTGTTTT AATTCCTGGA GCTGCTCTCG 120

GTCAAATTTT AGGTGGCTTC CTTGTTTCAA AATTCAGAAT GACATGTAAA AACACAATGA 180

AGTTTGCACT GTTCACATCT GGAGTTGCAC TTACGCTGAG TTTTGTATTT ATGTATGCCA 24 0

AATGTGAAAA TGAGCCATTT GCTGGTGTAT CTGAATCATA TAATGGGACT GGAGAATTGG 3 00

GAAACTTGAT AGCCCCTTGT AATGCCAATT GTAACGTACT CGAG 3 44

(2) INFORMATION FOR SEQ ID NO: 187:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 48 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 187:

GAATTCGGCA AGAGC CTAAA ATCTACAAGC ACCAGGAAGT CAAGATG CAA GCACCAGCCT 6 0

TCAGGGACAA GAAACAGGGG GTCTCAGCCA AGAATCAAGG TGCCCATGAC CCAGACTATG 120

AGAATATCAC CTTGGCCTTC AAAAATCAGG ACCATG CAAA GGGTGGTCAT TCACGACCCA 180

CGAGCCAAGT CCCAGCCCAG TGCAGGCCGC CCTCAGACTC CACCCAGGTC CCCTGCTGGT 24 0

TGTACAG AG C CATCCTGAGC CTGTACATCC TCCTGGCCCT GGCCTTTGTC CTCTGCATCA 300

TCCTGTCAGC CTTCATCATG GTGAAGAATG CTGAGATGTC CAAGGAGCTG CTGGGCTTTA 36 0

152

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AAAGGGAGCT TTGGAATGTC TCAAACTCCG TACAAGCATG CGAAGAGAGA CAGAAGAGAG 420
GCTGGGATTC CGTTCAGCAG AGCATCACCA TGGTCAGGAG CAAGATTGAT AG ATT AGAG C 4 80

GACTCGAG 4 8 8

(2) INFORMATION FOR SEQ ID NO: 18 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 163 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 188:

GAATTCGGCC AAAGAGGCCT AGGTCAGATG CATTAAAACA TAT CAAAATG TTACAAAAAT 6 0

GTATGGCTCC CTTGCTGAGG CCCTGTCAGA TTATG TTAGA TG AG TAAACG CATCAGTGTG 12 0

TAAGTT CAG A ACCAAACGTT GAATCAAGTC ATGTACTCTC GAG 163

(2) INFORMATION FOR SEQ ID NO: 18 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 310 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 189:

GAATTCGGCC AAAGAGGCCT ACCTGCTCAT ACCTGTGGCC AAAAGCATGA TGCCCCAGGC 60

TCTGCCTCCA ATTCTACCAT CTTCTTCCAT CTTTCTCTTT TATCAGGTCT CTGCCCTCCT 12 0

GTACTTTGTA CTTAGATTCT CCTCTGCCAA GCCCATTCAG ACTGTGACTG GTAGGAGTGC 18 0

TGTGCTCAGC TTTCCACTTG AGTGTTTATC CAAGAAGTTG GATAACCCTC TCAAGTTATG 24 0

GCCTCCATTC CAGTGCGCCT CAGTCTATGG GGATGCATTC CACTCACCCT TGGGCCTAGG 3 00

GCAGGTCGAG 310

(2) INFORMATION FOR SEQ ID NO: 190:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 516 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 190:

GAATTCGGCC TTCATGGCCT AGGGCCTCAG TCTTTTTACT TTTGCGGCTG TGTTTCTCTG 60

AAGGCTTGGC ATTAGTAGAT TGAAAAGAAT AACCATCTAG GGAAATGTGA ATTCAGTTTC 120

TTTCTGACAT TCTGCTCTCT ACAAGGGGAT ATTATGTACA CATAAACCTA CTTCCAAAAT 180

AATGAAGTGA GGCCTAATTC CTTACTCTTC AGAGAGCCCA CTGTGGAAGT GTCACTGACC 24 0

TTGTGTATGG GCTGCCCTTC ATGGCTCTGG GAGTCATTAT AAAGGG CAG C ATTTGGCGTG 30 0

GTGCGTCCTA AGCCAGTGTT TCTCGGCTCT GTTCCTTAAA CATGTGTTAG TGTTAATAGA 360

TGTTCTTGGA AAAAAAAAAA AAAAAACAGC AT TCTG AGGT CAAACATG CT CAGAAAGCTT 42 0

GGAATCTGCA CTACGCTTCT CGTACACATT TCATATTAAA GATTTTGGAA AGTCCTGCAA 4 80

153

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TACAGAGCCC TGTCTAATAT TGCCACAGCC CTCGAG 516
(2) INFORMATION FOR SEQ ID NO: 191:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 319 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 191:

GAATTCGGCC TTCATGGCCT ACTTGCTAGA TAGACAGATT AAGAATGTTG AAGACATGGT 60

CCAGTTTATT AATAACATTT TGGATGGCAC AGTAGAAGCC CAAGGAG GTG ATAGCATTTT 120

GCAGAGATTG AAAAGAATAG TATTTGATGC CAAATCTACT ATTGTGTCTA TATTCAAGAG 180

CTCACCACTG ATGGGCTGCT TTCTCTTTGG CCTGCCACTG GGTGTCATCA GTATCATGTG 24 0

CTATGGAATC TACACAGCCG ACACAGATGG AGGTTATATA GAAGAACGAT ATGAAGTGTC 3 00

TAAAAGTGAA AATCTCGAG 319

(2) INFORMATION FOR SEQ ID NO:192:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 192:

GAATTCGGCC TTCATGGCCT AAGCAGAAGG ACATATTAGA GAAGGATTGT ATAGTTTTCT 6 0

GGTAAAAGAT GACAGTGAAT TGTATGGGCG ATGGATT AG C CGTGGAAGGT GTTGAGTATA 12 0

AGTGGTCTCC AGCCAAACTC TATGGTTACT GGAATAAGAG AGTAGGAACC TTCTCAGGCT 18 0

TTATCTTTAT CTATTCTTGT CAACAGTATG TACATGTGTC CCCCAGCCCC AAATAACTGT 240

ACAGTTTAAT GATGTTCACT CTATACAGTT CCCAGAATCC ATTGGAAATT GCTGTAACAG 30 0

CATATCCTCA ATGCCCATCA ATTCTCCACG TCCAACTTCT CCATGGCCTC CTCTGCCTCT 360

GCTGATCTGT GAACTTCTCG AG 3 82

(2) INFORMATION FOR SEQ ID NO: 193:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 74 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 193:

GAATTCGGCC TTCATGGCCT AATATTTTTA AAGCGAAAGC TAACTTCTAA TTTTGAAAAT 6 0

TTTTATTGGG AGCAGGATAT TATAATAATA ATCTTTAGTT G TTAAAC CAT TAAACATCAA 12 0

GGTTTTTTAC ATTGTTTCTA TGCCTCCTCC CTCAAAAAAA AAAAACCTCC TACAATAAAA 180

CTGAAAAATT GCACAAAGAC ATATTAGTGG AAGACCACTG CTTCGTTTAC ACAAATGAAG 24 0

AGTATAAAGC AGAGAAGTGC TCCTTGGGGC AAAAGGCAAT TGGCAAAAAG CTAAGGAACA 3 00

TTTTCATAAT GAATTAGAAA TACAGATCAT CAGGAATATC CAGGAAG CGA TAGTGAATAC 360

154

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CAGGCAGGCT TAAGAGACAG GAAACATTTA GCATGTTGGT AAACCACTTT AGCACATCAG 42 0

CAAAAGCATA TAAACAG CTT TAGGATTGGA AATTATTGCC AGGGGGGACT CGAG 4 74

(2) INFORMATION FOR SEQ ID NO: 194:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 499 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:194:

GAATTCGGCC TTCATGGCCT ACGTNNCTAT GTCTTCAAGC AC AG AGGTG T CCAGGTGTAT 60

TGCACATCTT CATCGCACTG AGCTGCATGG ACAGCTGATT TCTGTGGAAA AAGTATAAGG 12 0

TGATCCCTCT CAGAAAGAAA TGAAGAAAGA AAATGATGAA AAGAGTAGTT CAAGAAGTTC 180

TGGAGATAAA AAAAATACGA GTGATAGAAG TAGCAAGACA CAAGCCTCTG TCAAAAAAGA 240

AGAGAAAAGA TCGTCTGAGA AATCTGAAAA AAAAGAAAGC AAGGATACTA AGAAAATAGA 300

AGGTAAAGAT GAGAAGAATG ATAATGG AG C AAGTGGCCAA ACATCAGAAT CGATTAAAAA 36 0

AAGTGAAGAA AAGAAGCGAA TAAGTTCCAA GAGTC CAGG A CATATGGTAA TACTAGACCA 4 20

AACTAAAGGA GATCATTGTA GACCATCAAG AAGAGGAAGA TATGAGAAAA TTCATGGAAG 4 80

AAGTAAGCAA ATGCTCGAG 4 99

(2) INFORMATION FOR SEQ ID NO: 195:

(i> SEQUENCE CHARACTERISTICS :

(A) LENGTH: 337 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 195:

GAATTCGGCC TTCATGGCCT AAGCAAAAGA G CATTAAGAA GTGTCTGTTT TTGTTATTGC 60

CATTTCATAA A TAT TTTAGT AGGTG TTCAA TTTCATTGGA TATTCTTTTT TTTTAATTGT 120

CTTTGTACCT ATGATTGAAA ACAGTAGTTG GTCTATGACT TTTGAGGAGA GGGAGAACCG 180

AAGATTACAG GAGGCCAGCA TGAGGTTGGA ACAAGAGAAT GATGACCTTG CCCATGAACT 24 0

AGTAACAAGC AAAATTGCTC TACGGAATGA CTTGGATCAG GCAGAAGACA AGGCAGATGT 300

GTTGAATAAA GAGCTCCTTT TGACCAAAAC CCTCGAG 337

(2) INFORMATION FOR SEQ ID NO: 196:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 86 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 196:

GAATTCGGCT TCATGGCCTA AAGGAAACTG ACAAATTATC CCCAGCTGCC AGAAGAAGAA 6 0

ATCCTCACTG GACGGCTTCC TGTTTCCTGT G GTT CATTAT CTGATTGGCT GCAGGGATGA 120
AAGTTTTTAA GTTCATAGGA CTGATGATCC TCCTCACCTC TGCGTTTTCA GCCGGTTCAG 180

155

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GACAAAGTCC AATGACTGTG CTGTGCTCCA TAGACTGGTT CATGGTCACA GTGCACCCCT 24 0

T CATG CT AAA CAACGATGTG TGTGTACACT TTCATGAACT ACACTTGGGC CTGGGTTGCC 3 00

CCCCAAACCA TGTTCAGCCA CACGCCTACC AGTTCACCTA CCGTGTTACT GAATGTGGCA 3 60

TCAGGGCCAA AGCTGTCATC CTCGAG 3 86

(2) INFORMATION FOR SEQ ID NO: 197:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 429 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 197:

GAATTCGGCC TTCATGGCCT AGTTTTTGTC TTTTTTTCTT TTTTGGTATT ATTTTGTTTG 60

CCACTTATTC CTAAAATTCA TATTGCTATT AACCGTACAC ATCTTTCCAT GTTCTTATAA 120

TAATCTACAA ACATCTCTCC CTTTCTGTAG CTCTCTCTGT CACACACACA CACATGCACA 180

CACGCACACA CACACACACA CACACGCTGT GCACTCTCCT GAAGCATGTG TGTACATACA 240

TACATATGTG AGGGGTTTTA TGACTGTTTT AC CAAATTGT GTTCTTAATA TATACAATGT 3 00

TGGCTTCTTT TTAGCCATTC AGAAGTTATT TCAGT CATGG AATGATCTCT AGCCATATAA 360

CTGAAAACAG GTAAGTTTCT TTCTTGGGGA AG AAG GGCGA ATGGTGATAG AG AAAATG G A 4 20

GAGCTCGAG 429

(2) INFORMATION FOR SEQ ID NO: 198:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 349 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 198:

GAATTCGGCC TTCATGGCCT ACCAAGCTAT GCAGGAACAG TTGTCTAAGA ACAAAGAACT 60

GACACAGAAA CTCCAGGTAG CCTCTGAGAG TGAGGAAGAG GAGGGAGGCA CAGAAG ATG T 120

GGAAG AACT C CTTGTCCCTG ATGTAGTGAA TGAAGTGCAG ATGAATGCAG ATGGGCCGAA 180

TCCCTGGATG CTCAGG AG CT GCACCAGTGA CACCAAAGAG GCTGCAACCC AGGAGGACCC 24 0

TGAG CAACTG CCAGAGCTTG AGGCCCATGG AGTTTCTGAA AGTGAGGGAG AAGAAAGACC 3 00

AGTGG CAGAA GAAGAAATTT TGTTGAGAGA ATTTGAAGAA AGGCTCGAG 34 9

(2) INFORMATION FOR SEQ ID NO: 199:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 312 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 199:

GAATTCGGCC TTCATGGCCT AGGGAAAGCT C CAACTTG CT TTACCTTTCT AAGATATCCC 60
ATTTTCTCTA TACCATTTGT TGACTAATAT ATCTCTTGCC CACTGGTTTG TAACAGTGCC 120

156

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TTAATTAGTT TTTGTGTTTG AAGTTCCAGA ATCTCTTCCT GGCCTATGTA TTGTGTTCCG 18 0

TTGATGGATC TTTCCATCCC ATGGTACCCT TTACTATTAT TGTCTTCATT TTTATTACTA 24 0

TTGTTATGCC CTTTTCTCTC TCCGTGCACA TCTTCATGTT TGAACTCTAA AAACACACCG 3 00

CCAACGCTCG AG 312

(2) INFORMATION FOR SEQ ID NO: 200:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 85 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 200:

GAATTCGGCC TTCATGGCCT AATATATCCA AGTAATAGCA TGTACAGTTT GGTAAGCAAT 60

ATAATAGAGA GATATTCACA GTGAAATAGG AAAGAGCAGT ATAGGTG CAA AGACAAAAAG 12 0

CATGACACAG CTAGATACAG GGCAGCTGTT ATTGGTTTTG TATGGAGAAA ACCTGGAGAA 18 0

ATGGTGAGAG AAGGGGCAGA AGATGAGAGG GGCCAGATCA TGGAGTACCT GTTTGTGGCG 240

CTCAGGAGTT TAGATGTTAT CATG CAG AT A ACTAGGAGCC ATTTGAGGAA CTTAAATACA 3 00

GGAGTGATAC CAGATTTATA TGTTTTTAAA ATGATTACTT GGTGGTAATT AAAGAAAAGA 3 60

T TGGATG ATT TAGGCAGATC TCGAG 3 85

(2) INFORMATION FOR SEQ ID NO: 201:

<i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 2 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 201:

AATTCGGCCT TCATGGCCTA CGTTTTTTTA AATTTTTTTA ACTACATATT TGATACGATC 60

TTTTCCTTCT TGCCTTCTTT TTGATTACTT ACTTTCTACC ATTCTATGTT TTTCGTCACT 120

AGTTTGAAAA TTGTATACTT TGTTTTTATT CTTTCAGTGG TTACC CTAG A AATTACAACA 180

AACAAAAATT GCAACAACCT CGAG 204

(2) INFORMATION FOR SEQ ID NO: 2 02:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 50 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 202:

GAATTCGGCC TTCATGGCCT AAAATCATCA TG CATATTT A TTTCTCCAAA GCACCTTTGA 60

CAAGCATGAT TTGGATAGAG ACTGTGCTTT GTCAC CTG AT G AG CTTAAAG ATTTATTTAA 120

AGTTTTCCCT TACATACCTT GGGGG CCAGA TGTGAATAAC ACAGTTTGTA CCAATGAAAG 180

AGGCTGGATA ACCTACCAGG GATTCCTTTC CCAGTGGACG CTCACGACTT ATTTAGATGT 24 0

ACAGCGGTGC CTGGAATATT TGGGCTATCT AGGCTATTCA ATATTGACTG AGCAAGAGTC 3 00

157

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TCAAGCTTCA GCTGTTACAG TGACAAGAGA TAAAAAGATA G ACCTG C AG A AAAAACAAAC 360
TCAAAGAAAT GTGTTCAGAT GTAATGTAAT TGGAG TGAAA AACTGTGGGA AAAGTGGAGT 42 0

TCTTCAGGCT CTTCTTGGAG AAGACTCGAG 4 50

(2) INFORMATION FOR SEQ ID NO:203:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 558 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS ; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:203:

GAATTCGGCC TTCATGGCCT AACTGGTTTC TGGCTCGTGG ANTCTGTTTC AAG AT CATAT 60

AAGCCGTTGC CATTCCCAAG NAGCGCTGGG ATATGCTCCT TCTCAGATGC TGCTATTTCA 120

GTGAAGGTAT TTAATGCTTG TTCAACATTA GATTTCTGTT TGGTAGCCAT TAAGCAATAG 180

TTTTCCATTA TGCGAANCTG TACGTGACCC TGAACAGTCT GAGGTTTTAG TTCCTTAANA 24 0

AGTTTTTCTG CTGTTCTTAC TGCCAGTTGC ACAGATTCTT GCTTCTCAGT TGAATAACCC 3 00

AGGTCTCCAT CCAGGTTTTC AAATACTTCA CCTCCAACAG TTTCATTATC TGGATTCAAA 360

CAGATCTCTA TCATATTATA AAGGGCATTT TGGCCCCAGT CACGATCTTT CCGAG CTTTA 420

TTAAAATGTC GAAGGGCATC ATTTGGTTCT CCAGTGTACC AAAGATACAG TCCTTTACAA 480

TACTGAAATC CTGGTTCCAA TTTTGCTCTG GAGNNACGTT TCTCAGCCAT TGAGAAAAAT 54 0

CTTGGGACAT CCCTCGAG 558

(2) INFORMATION FOR SEQ ID NO:204:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 8 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:204:

GAATTCGGCC TTCATGGCCT ACAAGTAGGG ACTGACTTCT CTAGGTTCCT ACAAAGCTCT 6 0

TCAACCACAC TCATTT CAAG CTCTGTCAGA ACAGCATCTG AATTAGGAGG ACTTTGGGAT 12 0

TCTGGGATAC AGGAAGTATC CAGAGCTTTG GATATAAAAA ACCCTGGGAC AGATATTTTG 180

CAGCCTGAAG AGACCTATAT AGACCCTACT ATGATACAAT CTTTAACTTT TCCTTTGGCC 24 0

CTTCATAATC AAAGCTCCGA TAAGACAGCT AACATTGTGG AAAACCCATG TCCTGAGATT 3 00

CTAGGAGTGG ATGTAATATC TAAAGAGACA ACTAGGAGGA AGCTCGAG 34 8

(2) INFORMATION FOR SEQ ID NO: 205:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 92 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 205:

GAATTCGGCC TTCATGGCCT AAGAAAAAAA AGAAAGAAAA AAAATGATAC TTTCCAGGTT 60

158

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CGCTTGGGTC CAGATCTGTA TTCCCAGGGC T C ATAGAG AT ATTGGCAAAC TGACAGATTT 120

CATGGCTCAA GAAACCTAAA GACACCTACT TGAATTCCTT TGGTTGGCAG TCAAATGTTA 180

ACTAGTGTGT TTTCAAGCTT CTATTCTTAG GCATGTTACT TCCTTTTGGA AGTCAAAACC 240

AACCATCTTT TAAGTAAGAG GGCTAACCAA ATATGTGCCA CACTAACTCG AG 2 92

(2) INFORMATION FOR SEQ ID NO: 206:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 220 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 06:

GAATTCGGCC TTCATGGCCT AAAATATTAA AATCTTTGAA GAAGAAGAAG TTGAATTTAT 6 0

CAGTGTGCCT GTCCCAGAGT TTGCAGATAG TGATCCTGCC AACATTGTTC ATGACTTTAA 120

CAAGAAACTT ACAGCCTATT TAGATCTTAA CCTGGATAAG TGCTATGTGA TCCCTCTGAA 180

CACTTCCATT GTTATGCCAC CCATCTCGAG GCAGGTCTAG 220

(2) INFORMATION FOR SEQ ID NO: 207:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 3 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 207:

GAAAAAATGG CCAAGGCTAC TGGGAAACTA AAGCCAACTT CTAAAGATCA GGTATTGGCC 60

ATGCTAGAGA AAGCCAAAGT TAACATGCCA GCCAAGCCTG CTCCACCCAC TAAAG CAACT 120

TCTAAACCAA TGGGAGGGTC CGCTCCAGCC AAATTCCAGC CTGCATCAGC ACCTGCTGAA 180

GATTGTATTT CCAG CAGTAC AGAACCCAAA CCTGATCCAA AAAAGGCCAA AGCTCCAGGA 24 0

TTATCCTCTA AAG CAAAG AG TGCACAAGGG AAGAAGATGC CAAGCAAAAC CAGCTTAAAG 3 00

GAGGATGAAG ACAAATCCGG GCCTATACTC GAG 33 3

(2) INFORMATION FOR SEQ ID NO: 208:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 316 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 208:

GGAGACAAGT TCTCCTCAGT GAACTGGCAG TACCAGTGTG GGCTTACCTG TGAGCACAAG 6 0

GCCGACCTTC TCCCTATCAG TGCATCCGTC CAGTTTATTA AAATTCCTGC ACAGTTACCC 120

CACCCCCTGA CAAGATTCCA GATCAATTAT ACAGAGTATG AC TG CAACAG AAATGAGGTG 180

TGTTGGCCGC AGCTTCTATA TCCATGGACT CAGTATTATC AAGGGGAGCT GCATTCTCAG 240

TGTGTTGCTA AGGGCTTACT GTTGCTGTTG TTCCTCACAT TGGCCTTGTT CCTCAGCAAC 3 00

CCCCGGACCA CTCGAG 316

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(2) INFORMATION FOR SEQ ID NO: 2 09:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 517 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 209:

GAATTCGGCC AAAGAGGCCT ATGTCCCTGT CCATCTTAGA GGCTGACCAA GCCCAGCCAT 60

GGGTGGTCCA AATTGCTTAG GTGGTCCCAA TTGCTTGGCT GGCCCAAGAG ATGTCTGGTT 120

CTTAACAATA CAAG AG CCTA TAG AAATTG C TAAAGGGATT T CAGCCACAA CTGAAGCTCA 18 0

CCAAGAATGA GTTTTCTGGA ACTGGTTAAA GTGTCACAGT AGGGAGTAAG GAAATAAGAA 24 0

TCCCCACCAA ACATAAGAGA ACAGAATGAT AATAGTCCCT ACTAGTCCAT GACAAGGCTG 3 00

CCAATTAGGC ATT'± AAAGCT ATCAAAGATG ATGCTGTGAG GGACCTGGCA ACTTTTGTAA 360

TAGTCTGACT TTAAATGTTT TATTAATGGC CAAGCAGCAA ATATTTTAGG ATTTGTAGGC 420

TATATGGTCT CTGTCCCAAT TACTCCATTC TGCTACTGTA GCATAAAAGC AG CG AT ACAT 4 80

CCTAAACCCG TCGATTGAAT TCTAGACCTG CCTCGAG 517

(2) INFORMATION FOR SEQ ID NO: 210:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 82 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:210:

GAATTCGGCC AAAGAGGCCT AAGAACATGA AACATCTGTG GTTCTTCCTT CTCCTGGTGG 60

CAGCTCCCCG ATGGGTCCTG TCCCAGGTGC AGCTGCAGGA GTCGGGCCCA GGACTGGTGA 120

AGCCTTCGGA GACCCTGTCC CTCACCTGCA CTGTCTCTGG TGATTCCATC AGTCATTACT 18 Q

ACTGGACCTG GATCCGGCAG CCCCCAGGGC AGGGACTGGA GTGGATTGGA TATTTCTATT 240

CACCCGGGAA CTCCAACTAC AATCCCTCCC TCAAGAGTCG AGTCACCATG TCAGTCGACA 3 00

CGTCCACGAA CCAGTTCTCC CTAAAACTCA NTTCTGTGAC CACTGCGGAC ACGGCCGTCT 360

ATTACTGTGC GAG AG AC CTA TATTGCCGTG GGGGAACCTG CTACCCCGCG AGACTTGACC 420

GCTGGGGCCA GGGAACCCGG GTCATCGTCT CGTCAGCCTC CACCAAGGGC CCATCGGTCT 480

TCCCCCTGGC ACCCTCCTCC AAGAG CACCT CTGGGGCACA GCGGCCCTGG GCTGCCTGGT 540

CAAGGACTAC TTCCCCGAAC CGGTGACGGT GTCGTGGAAT TCAGGCGCCC TGACCAGCGG 6 00

CGTGCACACC TTCCCGGCTG TCCTACAGTC CT CAGG ACT C TACTCCCTCA GCAGCGTGGT 660

GACCGTGCCC TCCAGCAGCT TGGGCACCCA GACCTACATC TGCAACGTGA ATCACAAGCC 720

CAGCAACACC AAGG TGG ACA AGAAAGTTGA GCCCAAATCT TGTGACAAAA CTCACACATG 7 80

CCCACCGTGC CCAGCACCTG AACTCCTGGG GGGACCGTCA GTCTTCCTC 82 9

(2) INFORMATION FOR SEQ ID NO: 211:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 2 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:211:

160

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GAATTCGGCC AAAGAGGCCT AGTTAATCTG ATAAATTCAC CATCAATTTG GTAAGCTTTA
ATATAACTAC CCTGTTTTTT GAATACAGAT AATG CAAAAG AAAACCATTT TATACTCGGC
TATATACCTT CCACCACTCG AG

60
120
142

(2) INFORMATION FOR SEQ ID NO: 212:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 555 base pairs

<B) TYPE: nucleic acid

(C) STRAND EDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 12:

GAAATTCGGC CAAAGAGGCC TAGTGGAATC ATTCTGCCAC ACCATTTCCT ACTCAAATAG 6 0

GTACAAACAT ACCACAGACA CTCCCATATA CACATGCTCC TCTATCCGCC AACTCTGGAA 120

CCAAAACTAA ATTGGTCTTC AAGAGAGATG ATGGCTTTAA GAACAAAAAT AGCCTTATCC 180

TCTATTTTAC TTGCTGTACT GTTGTACTGT TTATTTAAGA AACAAG CTGG TGGTTGATGT 24 0

CCAGGAAAAA TTATCTTTTC AAAATGAGGG AAGAGGAGGT TCACCATGTG GATATGGTGT 3 00

GCCTTTCAAC ATCCTTAAGG ATTGTTGATA TCATTATTGT TAATCAATTG TTGTCAGCAC 36 0

AGTGGCTGCC CAAG CTGTGC AAATGAAACA GCCAATCAGC AGGAGAAAGT GATGAAATTA 42 0

AATGACCTCT TTCCTTAACC ACTCATCCGT AAGCCTTGTT ATTTTTCATA CAAACCTCGA 4 80

GCCGGGGGAG GAGGGGCGGC GGCGAATGCT GGGAGAGTCA GGTCTAGAAT T CAATCGT AG 54 0

GCCTCTTTGG CCGAA 555

(2) INFORMATION FOR SEQ ID NO:213:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:213:

GAATTCGGCC AAAGAGGCCT ACGAGAAGGG CGGTGTGTAC AAAGGGCAGG GACTTAATCA 6 0

ACGCAAGCTT ATGACCCGCA CTTACTGGGA ATTCCTC 97

(2) INFORMATION FOR SEQ ID NO:214:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 87 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:214:

GAATTCGGCC AAAGAGGCCT AAGAAGAAAT TGGTAGATTG CGAGAAGAGA TAGAAGAATT 6 0

AAAACGTAAT CAGGAACTTT TACAAAGCCA GCTGACTGAA AAGGACTCTA TGATTGAAAA 12 0

TATGAAATCT TCCCAAACAT CTGGCACAAA TGAACAGTCT TCAGCAATAG TTTCAGCTAG 180

AGATTCTGAA CAAGTTGCAG AATTAAAACA GGAACTGGCA ACT TTAAAGT CTCAGTTAAA 24 0

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CTCACAATCT GTGGAGATCA CCAAACTACA GACAGAAAAG CAGGAACTGT TACAGAAAAC 3 00

AGAAGCGTTT G CAAAAT C AG TTGAGGTACA AGGAGAGACC GAGACTATAA TAGCCACCAA 3 60

AACTACTGAT G TAG AAGGAA GACTGTCAGC ATTATTACAA GAG AC CAAAG AG TTAAAG AA 420

TGAAATTAAA GCTCTGTCTG AGGAAAGAAC TGCCATTAAA GAGCAGCTGG ATTCATCTAA 4 80

TAGTACC 4 87

(2) INFORMATION FOR SEQ ID NO: 215:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 584 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO:215:

GAATTCGGCC AAAGAGG CCT ACTGGGCCTT TCAGCACCTG CTCCAGCTTC ACCTTGGTGA 60

ACATCAGGTT GAAGTTCTCA GGGTGCTCGG TGATGGCCAT GTTGACAACA TCCAGGGCAT 12 0

GCTGGTGGTG CTTCTGGGCA GAGAAGAGCA GTGCCAGCAG GTGGAGGGCG TGGGCATCAT 180

CCTTGCGTAC CTTCAGGGCC TCCTGCAGCT GCTCCATGGC ACTGGAGATC TGTCGGACGA 240

GGGCCAGCTG CAGCGAGACA TAGAGGATGA CCTGGGGGTC ACTGGGCGCC AG CTG CTG AG 3 00

CCCTCTCCAG CGTCTGCAGT GCCTTCCGGT GCAATTCATC TTGCTTGGAC TTCAGGGTGG 3 60

CGTCGGTGGC CTGCAGGCTA TAGGTGAGAC CCAGAGCCAG GTAGCCCTTG GGGAG GAACT 420

CCCCGGCTTC CTCTCCGAGG CTGATCACCA TCATGGCAAA GTGCTCTGCT TCCTCTAGCC 4 80

AG CG AAGGGA CCCGATG CAG ACCTTCGCGG CCATCAGGGG CACGGTGGGG TCCGAGGGCC 540

GCAACTTCAC ACACTCCCGC AGCAGGGACA CAGCGTAGGC TGAC 584

(2) INFORMATION FOR SEQ ID NO:2l6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 532 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 216:

GAATTCGGCC AAAGAGGCCT AGACCTGCCC TAAAGATAGA GTCTTGATGC ACCGTCTACC 60

TTGTCCCCAA CCAAGAGTGA GTAGTGCACA GAAGTCTCCT GGCACCCTGG GAATCCTGCA 12 0

TTTTTAATGG ACGAGCAGGG CAGGAAAGAA AAAAAAAACC CAAACCCCAT CACTCTGCCA 180

GCCCCTGTGA CCAAAGCAGC CCAAATCAGT TACCTTGACA ACTCTCATGC ACAGACTGCA 24 0

CCAGCCTGTG TTGCAAACAT CACTGCCCCG CTTCTAACAG GAAGAGATAC TCTTTTGGGG 3 00

GTCTTG CAGG GCCCAGGACC AGAGCCCCTT CTACCCAGGG CCCTTCCAAA GGCAAAGCAC 3 60

AGAGTCACAT TTGGGCGTGG CATGAGAGGG AAATAAAGAG ATTTGGCTGT AGTGGGAGGG 42 0

AGGTTT CAGT GCTTTTTCTG GGGACATTGG TGCCTATCTC TATTCTGAGA GTTGTTCTCC 480

T CAT AGG ACA CCATAAAT CG CATC CAGGAC CTGCTGGCTG AGGGTACTCG AG 53 2

(2) INFORMATION FOR SEQ ID NO: 217:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 269 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

162

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(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 17:

GAATTCGGCC AAAGAGGCCT AGTGTGTCCG GGTCTTATAC AAAAACAACA C AG TGAATG A 60

AGGAATAAAT ATTTATTGAA TGGAAAATCA GCAAAGGAAA AAATTGTATA ATTGTCAATG 120

ACAATGGGAA GCACATAGTG AGGCTATGAG TGATTTGGAA ATCATGAGCG TGCAGTGTTT 180

TGTTCACGCA TTTCGGTTGT GTTTTCAGAA AGTAACTACA ACATAG CATC ATGTAGCAGA 24 0

ATTGCTGGTT GTAAGCAAAA AGGCTCGAG 269

(2) INFORMATION FOR SEQ ID NO: 2 18:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 675 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 218:

GAATTCGGCC AAAGAGGCCT AATTCTTTTT CTTTTTAATT TGAAGAAAAA TCATCAGTCT 6 0

TGGAATACAG AAGAGAAACT AGAAATATAC GTATTTTGTT TCACATTTGA ACAGTCATTC 12 0

TTGAGGAATA CTCCATACCT GAGTAGACAG CCATGTGGCC ATCGCAGCTA CTAATTTTCA 180

TGATGCTCTT AGCTCCAATA ATTCATGCTT TCAGCCGTGC CCCAATTCCA ATGGCTGTGG 24 0

TCCGCAGAGA GCTATCCTGT GAGAGCTATC CTATAGAGCT TCG CTGTCCA GGAACAGACG 3 00

TCATCATGAT AGAAAGTGCC AACTATGG CA GGACTGATGA CAAAATTTGT GACTCTGACC 360

CTGCTCAGAT GGAGAAT AT C CGATGTTATC TGCCAGATGC C TAT AAGATT ATGTCTCAAA 420

GATGCAATAA CAGAACC CAG TGTGCAGTGG TGGCAGGTCC TGATGTTTTT CCAGACCCGT 4 80

GTCCAGGAAC CTATAAATAC CTTGAAGTGC AGTATGAATG TGTCCCTTAC ATTTTTCTTT 540

GTCCTGGACT ACTAAAAGGA GTATACCAGA GTGAACATTT GTTTGAGTCC G AC CACCAAT 600

CTGGGGCGTG GTG CAAAG AC CCTCTGCAGG CATCTGACAA GATTTATTAT ATGCCCTGGA 660

CTCCCTACAG AACTG 675

(2) INFORMATION FOR SEQ ID NO: 219:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 414 base pairs

(B) TYPE: nucleic - acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 19:

GAATTCGGCC AAAGAGGCCT ACTCCCTGTT TTGAACAAGT TTTTTTGAGA ATTCTTAGTT 60

TTAGTTTTTG TTTAG CTTAC ACACTGAAAA TTTTGAGAAG CATCTAAAAA AATCCACAAT 120

TAGTGCAAAA AGAGGGGACA ATACTTTAAG TCATTCCTTC TATAAAAAGA ATTAAGGTTA 180

CTAAATGCCA ATTTTTAAGC AAATATATAG TTTCCTATTT GCCTTCTGAA AGACAGCAGA 240

TATAAAAATA GTTCAATATT AGGTTTAACA AGGTTTGAAC AACACATGTA CTATCAGCTT 300

TATTTTACCT GCAAAAATAT TTTAGCTACA CTTGGAAAAA AATAAACTTG AGAATATAAC 3 60

TTCACATTTC TAAGGCCAGA TGCAAGAATA CTTATTTAGG CCTCTTTGGC CGAA 414

(2) INFORMATION FOR SEQ ID NO; 220:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 120 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

163

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(D) TOPOLOGY: linear
(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 220:

GACCGTCGAT TGAATTCTAG ACCTGCCTCG AGATTGGAGA CAGAAGGTCC CGGGAGCAGA 60
AAG CCAAACA GGAGCGGGAG AAAGAACTGG CAAAAGTCAC TATCAAGAAG GAAACTCGAG 120

(2) INFORMATION FOR SEQ ID NO: 221:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 33 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 221:

GAATTCGGCC AAAGAGGCCT AAG CAG C AG C TGCTTATATG CATGTGAACA GCTGGGGAAT 60

TAATTTGGTA TGCATTCTCA GGAGCCACTC ATCTGCTGGC AGAGGTAGCA GAAGAATGCC 120

CTTAGTGTAA GTCCTCTACA ACCATACACC AAATGTGCTC CCTGCATTTC AAATTCCATT 180

GTAGAAAGTC TCTGATAATC TCACTTATAC CATGAGCCAT TCCTCAGTAT CTGTCCTCTT 240

CCTGTTAGTG TTCTACAATT CCTTTCTCCT TAATTTTTCT CCGCTTTACA AAATGTCACA 3 00

CAGACAAGTG CATAATACTT AAACAAGCTC GAG 333

(2) INFORMATION FOR SEQ ID NO: 222:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 817 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 222:

GAATTCGGCC AAAGAGGCCT AAGAAAAGCA CCCTTATTAA GAATTGCAGC AAGTAAGCCA 60

ACAAGGTCTT TTCAGGATGA TTTTCTTATA TCAAGTGGTA CATTTCATTT TATTTACTTC 120

AGTTTCTGGT GAATGTGTGA CTCAGTTGTT GAAGGACACC TGCTTTGAAG GAGGGGACAT 180

TACTACGGTC TTCACACCAA GCGCCAAGTA CTGCCAGGTA GTCTGCACTT ACCACCCAAG 240

ATGTTTACTC TTCACTTTCA CGGCGGAATC ACCATCTGAG GATCCCACCC GATGGTTTAC 3 00

TTGTGTCCTG AAAGACAGTG TTACAGAAAC ACTGCCAAGA GTGAATAGGA CAGCAGCGAT 360

TTCTGGGTAT TCTTTCAAGC AATGCTCACA CCAAATAAGC GCTTGCAACA AAGACATTTA 42 0

TGTGGACCTA GACATGAAGG GCATAAACTA TAACAGCTCA GTTGCCAAGA GTGCTCAAGA 4 80

ATGCCAAGAA AGATGCACGG ATGACGTCCA CTGCCACTTT TTCACGTACG CCACAAGGCA 54 0

GTTTCCCAGC CTGGAGCATC GAAATCTTTG TCTCCTTAAA ACATCTGAGA GTGGATTGCC 600

CAGTACACGC ATTAAAAAGA GCAAAGCTCT TTCTGGTTTC AGTCTACAAA GCTGCAGGCA 660

CAGCATCCCA GTGTTCTGCC ATTCTTCATT TTACCATGAC ACTGATTTCT TGGGAGAAGA 720

ACTGGATATT GTTGCTGCAA AAAG TCACGA GGCCTGCCAG AAACTGTGCA CCAATGCCGT 780

CCGCTGCCAG TTTTTTACCT ATACCCCAAC GCTCGAG 817

(2) INFORMATION FOR SEQ ID NO:223:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 587 base pairs

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(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 223:

GAATTCGGCC AAAGAGGCCT AGGAGATACA TCATCATATC ACGGAAAGAG ATGCAGATAG 60

ATCTTTGACC ATACTTGATG AACAGTTATA CTCATTTGCG TTTTCCACCG TGCACATTAC 12 0

GAAGAAAAGA. AATGGAGGTG GGAGTTTAAA TAACTATTCC TCCTCCATTC CATTGACTCC 180

CAGCACCAGC CAGGAGGACC TTTATTTCAG TGTTCCTCCC ACTGCCAACA CACCCACGCC 24 0

CGTTTG CAAG CAGTCCATGG GCTGGTCCAA CCTGTTTACA TCTGAGAAAG GGAGTGACCC 300

AGACAAAGGG AGGAAAGCCC TGGAGAGTCA CGCTGACACC ATCGGGAGCG GCAGAGCCAT 3 60

CCCCATTAAA CAGGGCATGC TCTTAAAGCG AAGTG GGAAA TG G CTGAAG A CGTGGAAAAA 4 20

G AAATATG T C ACCCTGTGTT CCAATGGCGT GCTCACCTAT TATTCAAGCT TAGGTGATTA 480

TATGAAGAAT ATTCATAAAA AAGAGATTGA CCTTCGGACA TCTAC CAT CA AAGTCCCAGG 54 0

AAAGTGGCCA TCCCTAGCCA CATCGGCCTG CGCACCCATC TCTCGAG 587

(2) INFORMATION FOR SEQ ID NO:224:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 534 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID N0:224:

GAATTCGGCC AAAGAG CCTA AGTAGTTGCT GCCTTTCTTC AGATCAGGTT ACCACAATGC 6 0

CTCCCCGCTG CTGACGCTTC ATCCCCCACA CCTCCAGCCC CAGTTACCTG GAGCTTCTCA 120

GAACCCACTT TGCCGGTGCT AAAACACAAG AGGGGGTGAA AGTGGCTGCC AGTAATGGCC 180

AGAAACCAAC CACCAGAGGC CAGGCTGAAA GACAAGCTCC GGGTGTCCAG GGGCTGACGG 24 0

GCCAACCATG TGGCAGGTCC CAGGCCCCAC CCACTGCGCC ATCCGTCTCT GAGCTCCACA 3 00

GTGGTCCCAC TAATGGGAAC CTCCTCTAGG GAGAGTGATA CTGCACCTTC ACCCGTAGGA 360

CTCATATTTA TAACAATGTG TAATGGCTGT AGCAAAAAGC CCTTGTTTCT AGATGTAAAT 42 0

GGTCAAAGAA ACAAGCGCTC TATTGTTTTG AATAAAATAG TTCAAATGAG TCCTGTATCA 4 80

TTGTATCTCC TATTCTGGAT TAGTGCCTTT TGGACAGTAG ACTGTAACCT CGAG 53 4

(2) INFORMATION FOR SEQ ID NO: 225:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 118 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 225:

GCTCCACTCT CTCCCTATCC ATTTGTAAGA ACAGGCTCCC CTCGCCGAAT ACAGTTGTCT 6 0

CAAAATCATC CTGTCTACAT TTCCCCACAT AAAAATGAAA CAATGCTTTC TCCTCGAG 118

(2) INFORMATION FOR SEQ ID NO: 226:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 582 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 22 6:

GAATTCGGCC AAAGAGGCCT AAATTTTAGT AGAGATGGAA TTTCACCATA TTGGCCAGGC 60

CGGTCTCAAA CTCTTGACCT CAAGTGATCT GCCCGCCTCG GCCTCCCAAA ATGTTGAGAT 12 0

TACAGG CGTG AGCCACCATG CCTCTCTTAC ATTCTTTTCT TCTGTTCACT ACAGCCGTGG 180

AGAGCTCCGG GTTGTCCTGC ACATGTGCAC TGCCCTCTCT TTTATGGACC TTTTAGGCTG 24 0

GCTGCACCCT CCGTCTGTGT CACCCTCCTG CTCCTCCTCC ACCTGGCTAG TTCCTGTTGG 300

CCACTTTTGG AAATTCATGC CAGTCCAGTC CACCCTGAGT ACATCCTCTT TCTGTGTCAC 3 60

TGAGCTCACT ATGCTGGGTT TTATCTATGT CTCCCTCGCA ACTAGATCAT TCACGTCTTG 420

AAGTTAGGCA TCATGCGTTC TTCATTTCTG TACCTCCCAA CTCAATGCTT AGCACCCAGC 4 80

AGGGGCTCAA GACTGTGTGT GGAATGAAGG ATTCGTGTGA AAATGCAGGG AGATGGAAGG 54 0

CTGAGCGTTT CTGTTCCTTG ACCATTCCCG GGTTGGCTCG AG 582

(2) INFORMATION FOR SEQ ID NO:227:'

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 61 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 22 7:

GAATTCGGCC AAAGAGGCCT AAAAACTTAT AAATAAGTGA GACTACTGCC CCCTAGCCTA 60

AAATTCATTC CCTGCGCTCA CTCAACATCA TAGTTCTTTA GGAAGACAAG TTGTTCTATA 120

GCATAAAGAT ACAACCTATT TAGATAGTCT AAAGATTCTC CTCTGTTTCT CAAATACAGT 180

CAGTTATGCA GCTCAAAATG CCTCTCATTT TCCTG CTTTT TTTTCTTCTA CTATTGTTGC 24 0

CTCCAGGCTT TGCAGAAACA CATGTTATTC TCCCCCTAAA ATCTGTTCCT CTTCTAGTTT 3 00

TCTCTCTGCC AGCAATGGCA CCACACAGTC TTTTGGTTTT GCACCAGAGA ATTAGAGATG 3 60

AACCCCTCAT CTCTAATCTA TCACAAGTTT CCTCAGATTT AAACTCTCAA ATCAAGATGT 4 20

TTCTCACCAT TTCCATTACT ATTGTCCCCA GCTTTCTCGA G 461

(2) INFORMATION FOR SEQ ID NO: 22 8:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 13 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:228:

GCCTAAACCG TCGAT TGAAT TCTAGACCTA TCTCGAGAAA GAGTTGTTCT GGAAAGAAAT 6 0

GAAGAAAAGA GCAGAACCAA TCTCAAGCAG CCAAGTGGTG AAGTTGGATG TATGTG AC CC 120

TACGTCTCTC GAG 133

(2) INFORMATION FOR SEQ ID N0:229:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 22 9:

GAAAGGGATC AAAAAGAAAA AGTGATCGAA TGGAATCTAC TGATACCAAA CGACAAAAGC 6 0

CTTCTGTCCA TTCAAGACAA CTGGTTTCTA AGCCACTGAG CTCATCTGTT AGCAATAACA 120

AAAGAATAGT TAGTACAAAA GGAAAGTCAG CCACAGAGTA TAAAAATGAG GAATATCAAA 180

GATCTGAAAG AAACAAGCGT CTAGATGCTG ATCGGAAAAT TCGTCTATCA AGTAGTGCCT 24 0

CCAGAGAACC TTATAAGAAT CAACCTGAAA AAACCTGTGT CCGGAAAAGG GATCCTGAAA 3 00

GGAGGGCCAA ATCTCCTACG CCAGATGGTT CTGAGAGAAT TGGGCTTGAA GTGGATAGAC 360

GTGCAAGCAG ATCCAGCCAG TCTTCTAAGG AAGAAGTGAA CTCTGAAGAA TATGGCTCTG 4 20

ACCATGAGAC TGGCAGCAGT GGTTCTTCTG ATGAGCAAGG GAACAACACT GAAAATCTCG 4 80

AG 482

(2) INFORMATION FOR SEQ ID NO: 23 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 501 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(XX) SEQUENCE DESCRIPTION: SEQ ID NO: 23 0:

GAATTCGGCC TTCATGGCCT AGGGGATAAA TGTAAGCTTG TTAAAGTAAG CACCACACCA 6 0

TGTTTCTGTC TCCCCAGCAC CCAGCACAGT GCTGTGAACC TTGGCAGATG CTAGATAAAT 12 0

GTGTGTTGAA TGAATGTGCC TATGAAG CCA CAAAGATGCC ACATGTTAGT ATATCAGTGA 18 0

GAGGTGACTC CACAGTGCTC TCTGGAGAAG CAATATGAGT GACTGAAGAG TGGGGCCTTT 24 0

TGCTTTTGCC TGGATATAGG GGTGCTCTTC TACTGTAATT GGGTGTGGAA AAACTCTGGC 3 00

TTTATGGTAT TCCATTAGGT TCTTTTCATT TAAAGTAGTC TTAAAATCAA AGTATCCAAT 36 0

ATTTTAAAGC CACAAAGTAG ATTACATAAT TAGCAGAGAT TTT AG TCAGT AAAATGTTAG 42 0

AAATCAAACT ATAAGAAAAT TCAAGTCCTT TATTTTGTGT CTTGGGTATA TGTCATTATT 4 80

TTAAATTCCA CAGCTCTCGA G 501

(2) INFORMATION FOR SEQ ID NO: 231:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 326 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 231:

GAATTCGGCT TCGATTGAAT TCTAGGACTT GACAGAATTC GAGTTATCCT TCTCAGAACA 60

TGTG CAGAGT CTCTTTTTGC CTCACCATGT GGTCCTGTGC TCTTTCAGGT GGGAGTTTTG 120

GGGCCTCCAG GGCAGCAGGC ACCACCTCCA TATCCCGGCC CACATCCAGC TGGACCCCCT 180

GTCATACAGC AG CCAACAAC ACCCATGTTT GTAGCTCCCC CCCAAAGACC CAGCGGCTTC 240

TTCACTCAGA GGCCTACCTG AAATACATTG AAGGACTCAG TGCGGAGTCC AACAGCATTA 300

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GCAAGTGGGA TCAGAGCAAT CTCGAG 326
(2) INFORMATION FOR SEQ ID NO: 23 2:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 67 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 32:

GAATTCGGCC TTCATGGCCT AATCAGAAGC TTTTCAAAAT TCCGTCTTCA AGAAGAAACA 6 0

CCCGTGGAGG AAGAAGACAT TATACAAAAC AAATTTAGAA ACTGGGATCA TGAGTGGAAA 120

AACAAAGGCA AGAAGGGCTG CCATGTTTTT TAGACGTTGC TCTGAAGACG CCAGCGGTAG 180

CGCCAGTGGC AATvJCTTTGT TAT C AGAGGA CGAAAATCCT GATGCGAATG GGGTAACTCG 24 0

ATCATGGAAG ATTATTCTAA GTACAATGCT TACACTGACT TTTCTTCTTG TAGGACTCCT 3 00

AAATCATCAG TGGCTTAAAG AAACAGATGT TCCTCAGAAA TCCAGACAAT TATATGCCAT 360

G CTCGAG 3 67

(2} INFORMATION FOR SEQ ID NO: 23 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:233:

GAATTCGGCC TTCATGGCCT AAAGAAGAAT TGACACCTCT TGGAGTCCAC TTGGCACGAT 6 0

TACCCGTTGA GCCACATATT GGAAAAATGA TTCTTTTTGG AGCACTGTTC TGCTGCTTAG 120

ACCCAGTACT CACTATTGCT GCTAGTCTCA GTTTCAAAGA TCCATTTGTC ATTCCACTGG 180

GAAAAGAAAA GATTGCAGAT GCAAGAAGAA AGGAATTGGC AAAGGATACT AGAAGTGATC 240

ACTTAACAGT TGTGAATGCG TTTGAGGGCT GGGAAGAGGC TAGG CGACGT GGTTTCAGAT 3 00

ACGAAAAGGA CACACTCGAG 3 20

(2) INFORMATION FOR SEQ ID NO:234:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 58 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 234:

GAATTCGGCT TCATGGCCTA CGATGAGGCT GCTGTCATTT GTGGTGTTGG CTCTATTTGC 60

TGTCACTCAA GCAGAGGAAG GAGCCAGGCT TTTGGCTTCC AAATCACTGC TGAACAGATA 120

CGCCGTGGAG GGACGAGACC TGACCTTGCA GTACAACATC TACAATGTTG GCTCAAGTGC 18 0

TGCATTAGAC GTGGAACTAT CTGATGATTC CTTCCCTCCA GAAGACTTTG GCATTGTGTC 24 0

TGGAATGCTC AATGTCAAAT GGGACCGGAT TGCCCCTGCT AGCAATGTCT CCCACACTGT 300

GGTCCTGCGC CCTCTCAAGG CTGGTTATTT CAACTTCACC TCGGCAACAA TCCTCGAG 358

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(2) INFORMATION FOR SEQ ID NO: 235:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 513 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 23 5:

GAATTCGGCT TCATGGCCTA GTTGTACGTA ATGTATTTAT ATGTTAATTT GTTATGTATA 60

TAGATGTGCA AGTCTTGTCA GAATTGGCCT CAGTGTAGTT AAAGGGCAGA AGGGGAAGAT 120

ACTGACTAGT CATAGAAATA CCTCATTCGC CTGTGGGAAG AGAAGGGAAG CCTCTTCAGG 180

GTGAGTGAAT GGCAAAGCGG TTGCTTCTGG CTCCTCCTTC CCCTGTGGTC TTGGAAGTGT 24 0

GTGGAAGGCA GGGACAGAGA TGGAGGCCGA GCCAATAGAC TGAAGAG AC C ACAGCAATTG 3 00

GCTCCTCCAT CTAGAGATTT TCTTGGCAGT ATTCCATGGG ATGTTAAGCA AAGGAAACCA 3 60

AAGGAATCGT TTCAAATGGA CTCATGGCTT AGAAAT CTTT ATTCTTAGGG CAGTCAGTAG 4 20

TATTCTAAAG CTTTCTGACA AGATAAAGGA AGTCACCAAA ATTTCTTTTT TTAAAT TGTA 4 80

TCTAATCCTC AACAACAAAC CAAAACTCTC GAG 513

(2) INFORMATION FOR SEQ ID NO:236:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 412 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID N0:236:

GAATTCGGCC TTCATGGCCT ACTTGGAAAT GTTTGATGCT ACTCTGAAAG ATCGAGAACT 60

GAGCTTTCAG TCGGCTCCAG GTACTACCAT GTTTCTGCAT TGGCTAGTGG GAATGGTATA 120

TGTCTTCTAC TTTGCCTCCT TCATTCTACT ACTGAGAGAG GTACTTCGAC CTGGTGTCCT 180

GTGGTTTCTA AGGAATTTGA ATGATCCAGA TTTCAATCCA GTACAGGAAA TGATCCATTT 24 0

GCCAATATAT AGGCATCTCC GAAGATTTAT TTTGTCAGTG ATTGTCTTTG GCTCCATTGT 300

CCTCCTGATG CTTTGGCTTC CTATACGTAT AATTAAGAGT GTGCTGCCTA ATTTTCTTCC 3 60

ATACAATGTC ATGCTCTACA GTGATGCTCC AGTGAGTGAA CTGTCCCTCG AG 412

(2) INFORMATION FOR SEQ ID NO:237:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:237:

TTCATGGCCT AGAGATATGC TTCTTTGTAC CAATATGGAA AATCTAAAAG AAAAAACCCA 60

CACTCAGCAC TATGAATGTT ATAGG TACCA AAAACTGCAG AAAATGGGCT TTACAGATGT 120

GGGTCCAAAC AAC CAGCCAG TTAGTTTTCA AGAAATCTTT GAAGCCAAAA GACAAGAGTT 18 0

CTATGATCAA TGTCAGAGGG AAGAAGAAGA GTTGAAACAG AGATTTATGC AGCGAGTCAA 24 0

GGAGAAAGAA GCAACATTTA AAGAAG CTG A AAAAG AG CTG CAGGACAAGT TCGAGCATCT 3 00

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TAAAATGATT CAACAGGAGG AGATAAGGAA GCTCGAG 337
(2) INFORMATION FOR SEQ ID NO: 23 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 750 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 238:

GAATTCGCGC ATTCGGTACA ACAAGAGAGA TAAACGATGA AACCGTTACA TTATACAGCT 60

TCAGCACTGG CGCTCGGACT GGCGTTAATG GGGAATGCAC AGGCAGTGAC GACCATTCCG 120

TTCTGGCATT CTATGGAAGG GGAACTGGGT AAAGAGGTGG ATTCTCTGGC CCAACGTTTT 180

AACGCCGAAA ACCCGGATTA CAAAATTGTA CCGACCTATA AAGGCAACTA CGAACAGAAT 240

TTAAGCGCGG GGATTGCCGC ATTTCGTACC GGCAACGCGC CGGCTATTTT GCAGGTTTAT 3 00

GAAGTTGGCA CCGCCACCAT GATGGCGTCG AAAGCCATTA AACCGGTGTA TGACGTGTTT 3 60

AAAGAGG CAG GGATTCAGTT CGATGAGTCG CAGTTTGTGC CGACGGTTTC AGGTTACTAC 420

TCCGACAGCA AAACGGGCCA CTTACTCTCC CAG C C ATT CA ACAG CTCGAC CCCCGTTCTC 4 80

TATTACAACA AAGACGCCTT CAAGAAAGCA GGATTAGACC CGGAACAGCC GCCGAAAACC 54 0

TGGCAGGATC TGGCGGACTA TGCCGCGAAA CTGAAAGCCT CCGGCATGAA GTGCGGCTAC 6 00

GCCAGCGGCT GGCAGGGCTG GATCCAACTG GAAAACTTTA GCGCCTGGAA CGGTCTGCCG 660

TTTGCCAGCA AAAACAACGG CTTTGACGGC ACGGACGCGG TGCTGGAGTT CAATAAGCCG 72 0

GAGCAGG TGA AACACATCGC CATG CTCGAG 7 50

(2) INFORMATION FOR SEQ ID NO: 239:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 490 base pairs

(B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 239:

GAATTCGGCC TTCATGGCCT ACTTACAGAA CCTATTCACT GGGAAGGAAG CCCTCATTAT 6 0

AATGATTTTC ATTCTTATGT GTGTTTCAGG ACGACTGGGT TTGGATTCAG AAGAGGATTA 120

TTATACAC CA CAAAAGGTGG ATGTTCCCAA GGCCTTGATT ATTGTTGCAG TTCAATGTGG 180

CTGTGATGGG ACATTTCTGT TGACCCAGTC AGGCAAAG TG CTGGCCTGTG GACTCAATGA 24 0

ATT CAATAAG CTGGGTCTGA ATCAGTGCAT GTCGGGAATT ATCAACCATG AAGCATACCA 3 00

TGAAGTTCCC TACACAACGT CCTTTACCTT GGCCAAACAG TTGTCCTTTT ATAAGATC CG 3 60

TACCATTGCC CCAGGCAAGA CTCACACAGC TG CTATTG AT GAGCGAGGCC GGCTGCTGAC 420

CTTTGGCTGC AACAAGTGTG GGCAGCTGGG CGTTGGGAAC TACAAGAAGC GTCTGGGAAT 4 80

CAAC CTCGAG 4 9 0

(2) INFORMATION FOR SEQ ID NO:240:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 425 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 240:

GAATTCGGCC TTCATGGCCT ACTTCTGGAC TCTATAGAAC CCACTGCCTC CTGATGAAGT 6 0

CCCTACTGTT CACCCTTGCA GTTTTTATGC TCCTGGCCCA ATTGGTCTCA GGTAATTGGT 12 0

ATGTGAAAAA GTGTCTAAAC GACGTTGGAA TTTGCAAGAA GAAGTG C AAA CCTGAAGAGA 18 0

TGCATGTAAA GAATGGTTGG GCAATGTGCG GCAAACAAAG GGACTGCTGT GTTCC AG CTG 24 0

ACAGACGTGC TAATTATCCT GTTTTCTGTG TCCAGACAAA G AC T AC AAG A ATTTCAACAG 3 00

TAAC AG CAAC AACAGCAACA ACAACTTTGA TGATGACTAC TGCTTCGATG TCTTCGATGG 36 0

CTCCTACCCG TTTCTCCCAC TGGTTGAACA TTCCAGCCTC TGTCTCCTGC TCTAGGATCC 4 20

TCGAG 425

(2) INFORMATION FOR SEQ ID NO: 241:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 61 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:241:

GAATTCGGCC TTCATGGCCT AACCAGAACT AATTTG CTAA GTCTTTTGTT TAGTCCTGCA 60

AGACTGATGC TTAATACACA GTCTGTTCTC CTGTGTCTAG GTCAGGAACT CCAGTTTGCT 12 0

TTTCTGTTTT GTGTCCTGGT AGCAGCTGTT GAGTAACTTT CATTGGAGGT TGGGAAGGAA 18 0

GTGAGGAGAA AGTGTTCTTG TTTAGTGTTT TATTTCCTAT AATAGGATGC TGCCTAACCC 24 0

AGTTCATCTC TATGTCCTGT TCACTGAATA TTCCGGGTAA TTGAAAGAAA ATATAATGGA 3 00

TGGGCTCCAT TAAAACCAGC TCAAAAATAA ATTCTTGTCA GTAAAGATTT CTTGTCAAGA 360

TGTCTTGGAT TGCACTTTTG TTGAGGAAAG ACAGTGTAAA TAGTTAAAGA ATGTTGATAA 420

AATTGAAACA TTTGGTTGTG GAATTGTGTG TGGTACTCGA G 461

(2) INFORMATION FOR SEQ ID NO: 242:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:242:

GAATTCGGCC TTCATGGCTT ATGGACAAGG AAGCATTCAG AGCATGGTGT CATCTGACTC 60

CACATCACCA GATTCTTCTT TAACAGAAGA ATCACGTTCT GAGACAGCCA GTAGTTTATC 120

C GAG AAG ATT TGTAATGGGG GATTATCTCC TGGTAACCCA GGAGATTCTA AGGACATGAA 180

GGAAATTGAG CCCAATTATG AAAGTCCCTC TAG T AAT AAT CAGGATAAAG ATTCATCACA 24 0

GGCTTCCAAA AGCTCAATAA AAGTTCCAGA GACCCACAAA GCAGTCCTTG CTCTCCGATT 300

AGAAGAGAAA GATGGCAAGA TTG CTGTACA AACTGAGAAG GAAGAAAGTA AAGCCTCTAC 3 60

AGATGTTGCT GGGCAAGCAG TAACCATAAA CCTTGTCCCC ACAGAAGAGC AAGCAAAACC 4 20

TTACCGAGTT GTGAACCTGG AACAGCCATT GTGCAAGCCA TATACTGTCG TGGATGTGTC 4 80

AG CAGCCATG GCCAGTGAGC ACCTCGAG 508

(2) INFORMATION FOR SEQ ID NO:243:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 23 base pairs

(B) TYPE: nucleic acid

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(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24 3:

GAATTCGGCT TCATGGCCTA GGTTTTCTGT ACATGGAGAT TAAACTGTCT TCCAAAGTGA 60

AGAGTTTATT GTTCTAGATC TTGAG CACAA AGGTTGGTAT ACGTTAATAA AAAAAATAGC 12 0

AAGGGAAGAA AATCATTTCC TTCATACCAA GTAAGAGAGC ACTTATCATG GTAGGCACTG 18 0

GCTTTGCAAT TATGAGACCA GTAGTAGAAA TAGCTTTAGT TTCCTCAATT TTCCTGGAGT 24 D

ATTCTTCAGA CTTTCTTTAC ACTGCTCAAG GTGGGGCGAG TGGCAGGGCG GACCCTGGCG 3 00

ACCTGACGCT GCGGAGGCTC GAG 32 3

(2) INFORMATION FOR SEQ ID NO: 244:

(i) SEQUENCE CHARACTERISTICS:

(A; LENGTH: 3 96 base pairs

<B) TYPE: nucleic acid

<C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:244:

GAATTCGGCC TTCATGGCCT AGCTTCAGTA GCAAATAAGG ACATCATCTG CTATAACCTA 60

CAAGCAGTTG GACAGATATT CTACATTTCC TCATTTCTCT ACACCGTCAA TTACATCTGG 120

TATTTGTACA CAGAGCTGAG GATGAAACAC ACCCAGAGTG GACAGAGCAC ATCTCCACTG 180

GTG AT AGAT T ATACTTGTCG AGTTGGTCAA ATGGCCTTTG TTTTCTCAAG CCTGATACCT 240

CTGCTATTGA TGACACCTGT ATTCTGTCTG GGAAATACTA GTGAATGTTT CCAAAACTTC 3 00

AGTCAGAGCC ACAAGTGTAT CTTGATGCAC TCACCACCAT CAGCCATGGC TGAACTT CCA 36 0

CCTTCTGCCA ACACATCTGT CTGTAGCACA CTCGAG 396

(2) INFORMATION FOR SEQ ID NO: 245:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 370 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24 5:

GAATTCGGCC TTCATGCTTA GCCTCAGCTC TTTCTTCTGG GTTGTTTGTA TTTTCTTTTC 6 0

TGTCCCAAAC AGTTTCCCCC ACAAAAAGAA CTTTATGTCT TTCTCTGTCT TCCCTCAGTC 120

CTTCCAGTCA GCAGCCTGTG ATTGGGCTTT TCCCCTCAGA AACGAACAAT CCAGAACCCA 180

CTGTTTAAAA CAACTGTATT TTGCCTTGGG AAGTCCCATT GCCTTCCCTG AAAACATTAA 24 0

ACATTCCTCC GATCCCCAGC CTGAGTCTCT CTGTCTCTGG GCCCCATCCT GCTCCACAGC 3 00

AGGGCTGGTG TGTCCAGCAC AGAGTGACCC TCCGATGCCC TTTCCCACCC GCCGCCCTGC 360

CTCCCTCGAG 370

(2) INFORMATION FOR SEQ ID NO: 246:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 67 base pairs

(B) TYPE: nucleic acid

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(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

tii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 246:

GAATTCGGCC TTCATGCCTA GAGAACTTGA AGCTTTGCGG CAGGAATTTA AAAAGAAAGA 60

CAAGACGTTG AAAGAGAATT CCAGAAAGTT GGAGGAAGAA AATGAGAATC TCCGAGCAGA 120

GCTACAGTGT TGTTCTACAC AACTGGAATC CTCTCTCAAC AAATACAACA CCAGCCAGCA 180

AGTCATCCAA GACTTGAATA AAGAGATAGC CCTTCAGAAG GAGTCCTTAA TGAGCCTGCA 240

GGCCCAGCTG GACAAAGCTC TG CAGAAGG A GAAGCACTAT CTCCAGACTA CCATCACCAA 3 00

AGAAGCCTAT GATGCATTAT CCCGGAAGTC AGCCGCCTGC CAGGATGACC TGACACAAGC 3 60

CCTCGAG 3 67

(2) INFORMATION FOR SEQ ID NO: 24 7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 4 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24 7:

GAATTCGGCC TTCATGGCCT ACGGCTTCAT AGTAACTCTT TGCCATATCT CTAGCCAGCT 60

GCATAAAACG TTCGCCATCA GATGGAGACA AAAGGTT TAA AATACGCCTA TAACCATCCA 120

TGGCCATTTT ATGATCACCC ATCTGTTCAT AAAGGCTTGA TCGCTCCCAC AGATAACGGA 1B0

CATTAGTAGG TTCATATTTA AGAGCTTTTG TATAGCAAAA AATAGCCTGC TTAATATTGT 240

CTTGTTCCAG AGACATTTCT GCCAGTCTAA CCCATTCTTC TGTGTCACTG GGATTTAAAT 300

GCGCAG CAAT CAACTCAAAC TGCAATGATT TTTCCATGTC ACCTTGGTCC TCATATATCA 360

TGGC TAGAGT AGAGAATGGC TCATAAGCCA GAGGAGCTTG TCTTATGATT TCCATGCACA 4 20

TCAATATCGC CTCTTCACGT TCTCCTCGAG 4 50

(2) INFORMATION FOR SEQ ID NO:248:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 08 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24 8:

GAATTCGGCC TTCATGGCCT AACGAAACTG ACGTCTACCT CATGGGGCTG CTGTGTGGGT 60

TTGGGAGGCA AAAATCTATG AAGGGTTTTT TGAAATCCCA TAGGTGCCAC ATCTATGAGA 120

TGTTTGATAA ATGTGAATAT GCTTTTACAT TTGGGCTTAT CTAATTTGCA ATAAGAGAGC 180

CTCTCTCTAT CAACACCAGC TTCTCTCTCG GGCTGTTTGC TCAGGGAAGG CAAGAAAGCC 240

ACGTGCTGGC CCTCTGCCTT CTCTAAAGTG CTGTTGGAGC ATGGAGGAGC TGGAGGAGAT 3 00

GGGGATGGAC TGACAGCTAA GAGGGCGGCT GCTGGGACTA GATAGTGGAT GAAGAAAGAA 360

GGACGAGGAA GCCGTGGGGC AGCCTCTTCA CATGGGGACG AACTCGAG 4 08

(2) INFORMATION FOR SEQ ID NO: 24 9:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 562 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 24 9:

(2) INFORMATION FOR SEQ ID NO: 250:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 313 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 50:

GAATTCGGCC TTCATGGCCT ACCCAAACAG ACAGAAAACG CCACGAGGCA AGTGTAGTCT 60

CTCACAGCCT GGACCCTCTG TCAGCAGTCC ACATAGCAGG TCCACAAAAG GTGGCTCCGA 120

TTCCTCCCTT TCTGAGCCAG GGCCAGGTCG GTCCGGCCGC GGCTT CCTGT TCAGAGTCCT 180

CCGAGCAGCT CTTCCCCTTC AGCTTCTCCT GCTCCTCCTC ATCGGGCTTG CCTGCCTTGT 24 0

ACCAATGTCA GAGGAAGACT ACAGCTGTGC CCTCTCCAAC AACTTTGCCC GGTCATTCCA 300

CCCTATGCTC GAG , 313

(2) INFORMATION FOR SEQ ID NO: 251:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 291 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 251:

GTCTTGACAA AACCTAACTT GCGCAGAAAA CAAGATGAGA TTGGCATGGC TTTATTTGTT 60

TTTTTTGTTT TGTTTTGGTT TTTTTTTTTT TTTTGGCTTG ACTCAGGAGA TCCCTCCCCG 120

GGGCTCCCGC CGGCTTCTCC GGGATCGGTC GCGTTACCGC ACTGGACGCC TCGCGGCGCC 180

CATTTCCGCC ACTCCGGATT CGGGGATCTG AACCCGACTC CCTTTCGATC GGCCGAGGGC 240

AACGGAGGCC ATCGCCCGTC CCTTCGGAAC GGCGCTCGCC CAACTCTCGA G 291

(2) INFORMATION FOR SEQ ID NO:252:

G C CCATG AC A
GGCTGCTCAG
TACCGAAGCC
GGAACTGGAG
GGAGAAGATG
TGAGGAGGCA
ACAGAAGCCC
CACTGAGGCC
CAAAGGGTCC
AG CG CGAATT

GAG AG CAGTG CCAAAGACAT GGCGTACGAA CATCTGATAG ATGACTTATT
AAGGAAATT C TGTCTCAGCA GGAAGTCATC ATGAAGTTAA GGAAAGACCT
CACAGCAGAA TGTCGGATTT GAGAGGGGAG CTAAACGAGA AGCAGAAGAT
CAGAACGTGG TGCTGGTCCA GCAGCAGAGC AAGGAGCTGA GTGTGCTCAA
GCCCAGATGA GCAGCCTGGT AGAAAAGAAA GATCGGGAGC TGAAGGCCCT
CTCAGGGCTT CCCAAGAGAA ACACAGACTC CAGCTGAACA CAGAGAAGGA
CGGAAGAAGA CCCAGACGTG TGACACCTCT GTGCAGATAG AACCCGTCCA
TTCTCCAGCA GCCAAGAGCA GCAATCCTTC AG CGATCT AG GGGTCAGGTG
CGGCACGAGG AGGTCATTCA GCGTCAGAAA AAGGCCTTAT CTGAACTTCG
AAAGAACTCG AG

60
120
180
240
300
360
420
480
540
562

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 84 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

( D ) TOPOLOGY : 1 inear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 252:

CGGGAAATGA AGCGGAAGCA GGCGGAGTCC GAGAGGCCCA TCTTGCCAGC CAATCAGAAG 6 0

CTCATTACTT TATCAGTGCA AGATGCACCC ACAAAGAAAG AGTTTGTTAT TAACCCCAAC 12 0

GGGAAATCCG AGGTCTGCAT CCTGCACGAG TACATGCAGC GTGTCCTCAA GGTCCGCCCT 180

GTCTATAATT TCTTTGAATG TGAGAACCCA AGTGAGCCTT TTGGTGCCTC GGTGACCATT 24 0

GATGGTGTGA CTTACGGATC TGGAACTGCA AGCAG CAAAA AACTTG CGAA GAATAAAGCT 3 00

GCCCGAGCTA CACTGGAAAT CCTCATCCCT GACTTTGTTA AACAGACCTC TGAAGAGAAG 36 0

CCCAAAGACA GTGAAGAACT CGAG 334

(2) INFORMATION FOR SEQ ID NO: 2 53:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276' base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 53:

GGGACGTTGG TGTTGAGGTT GGCATACGTA TCAAGGACAG TAACTACCAT GGCTCCCGAA 60

GTTTTGCCAA AACCTCGGAT GCGTGGCCTT CTGGCCAGGC GTCTGCGAAA TCATATGGCT 12 0

GTAGCATTCG TGCTATCCCT GGGGGTTGCA GCTTTGTATA AGTTTCGTGT GGCTGATCAA 180

AGAAAGAAGG CATACGCAGA TTTCTACAGA AACTATGATG TCATGAAAGA TTTTGAGGAG 24 0

ATGAGGAAGG CTGGTATCTT TCAGAGTGTA CTCGAG 276

(2) INFORMATION FOR SEQ ID NO:254:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 254:

GAGTTTGTTG GGCTTACCTT ATTTTAATTA AAAAGAAGTC GGGGCTACCA GGGGTTTCAG 6 0

ACGTGCTCGA TGGACACGTG ATTTGTAAAC AGCCAAGATT CTGGGGGACG GGGGGGTGCC 120

TCGGTGGGGT TGACATTTGA GTTACAGGGA CTTAATAATG GCCAGCCTTT CACATCCCAT 18 0

GGGAAACCGC CCCCCCGGGC CTTGGAGAAT GGGGGTCCAA GTGCCTATCC CCCTTTGGAT 240

GTAAAATTCA TCGTTAGTAA ACATCATCCG CCCAGCAACA AGCAAAGCAC ATCG CAAGAT 300

TAAAACAAAG AATCCGCCGT GAACAGAAGG CCTCCATCTC TGCTCTCAGG CAGGTGTCCT 3 60

TCAGGGAGGA GCCTCAGGCA GCTGTTCTAA CCCTGCTGCC AACGCCTGGG CTGTTTCTGC 420

CGACAATCTT CTATTTCTCT AAAAGAG T AC GCTGAACAGC TGGCTCTGCG TTGATTGAAT 4 80

TCTAGACCTG CCTCGAG 497

(2) INFORMATION FOR SEQ ID NO: 255:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 70 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 255:

GAATTCGGCC TTCATGGCCT AGAGAACCGT TGCTTTTCCG AGTTGCTCTT CTTCCAGGCT 6 0

CCGTTGGTGG TCGGCATGGC CCGTGGAAAT CAACGAGAAC TTGCCCGCCA GAAAAACATG 120

AAGAAAACCC AG GAAATTAG CAAGGGAAAG AGGAAAGAGG ATAGCTTGAC TGCCTCTCAG 180

AGAAAGCAGA GGGACTCTGA G ATCATG CAA GAAAAGCAGA AGGCAGCTAA TGAGAAGAAG 240

TCTATGCAGA CAAGAGAAAA GTGATGACTG GCTATTTGGA AAACCTGGGT GCTACTGCCA 3 00

ACTGGGTGTA TCATAAGCTC TAAGATCAAG ATTTTGTAGA GTGGACAGTC ATTACATATG 360

TTATAACTTA TCCTTTAAAA ACTATTTTAA ACTTTATCCT TTCAGCTTTA CTTAGTGCGA 42 0

TGTTTTAGAA GCAGTCTTCA AAGAATAAAA CACTAACCAT GCTGCTCGAG 4 70

(2) INFORMATION FOR SEQ ID NO: 256:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 88 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO^S:

GAATTCGGCC TTCATGGCCT AATTTTGTAT TTTTAGTGGA GACGGGGTTT CTCCATGTTG 6 0

GTCAAGCTGG TCTTGAACTC CCAACCTCGG GTGATCCGCC CGCCTTGGCC TCCCAAAGTG 120

CTGGGATTAC AGGCGTGAGC CACCGCGCCT GGCCAGTAGT TTCTTAACAT TAAATTATCC 18 0

GCAAAATGGA AGAAATACTA GAGGT CTGTG AGGATGTTTC TTCTCTTTCA GTCTGTTGTG 240

GTGGTTTGTA GTTTACAGGG GCTTGGGTAA CTGGATTTTT AGGTTTATTA TTTTAAATAG 300

TAGACTCAAC ACTATTTTGT ATTG CAGTAG AGATCACTTA TGCAG AT CTT TTTAATACCA 360-

TTTCATAGAG ATTAAGGGTC ACCTCGAG 3 88

(2) INFORMATION FOR SEQ ID NO: 257:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 33 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 257:

GAAACAGGGC TCAAAGAAGT GGTAACTGCT GTGGAGGAAA TGACAAGTAA AGGAAAACCA 60

GGACAAGAAG TCTTGGAAGA CGACCAGGAA AATACTTTAA AATATGAGTA TGAAGAAGAC 12 0

TTTGAAGTAG ATGAGGAGAA ACAAGGTGAA AAATCTAATG AAGAAGGACA GGCTGATGTT 180

CAAATGAATG GAATACCGCA GTCACCTTTG GATGATAAAA AAGATAATTT AG AC CCTGAA 240

AAAGAGAGTG AAACCTCATC ACAGAAGGCA CCAGATGCCC GTGACAATGT GAAAGATGAG 30 0

AATGATGGAT GCTCTGAGAG TGAACGTCTC GAG 33 3

(2) INFORMATION FOR SEQ ID NO:258:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 544 base pairs
{B ) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 258:

CACAGTGCTG GNTCACAACA AGATGNTCNA GGTGTCAGCC GTACTGTGTG TGTGTGCAGC 6 0

CGCTTGGTGC AGTCAGTCTC TCGCAGCTGC CGCGGCGGTG GCTGCAGCCG GGGGGCGGTC 120

GGACGGCGGT AATTTTCTGG ATGATAAACA ATGGCTCACC ACAATCTCTC AGTATGACAA 180

GGAAGTCGGA CAGTGGAACA AATTCCGAGA CGATGATTAT TTCCGCACTT GGAGTCCAGG 24 0

AAAACCCTTC GATCAGGCTT TAGATCCAGC TAAGGATCCA TGCTTAAAGA TGAAATGTAG 3 00

TCGCCATAAA GTATG CATTG CTCAAGATTC TCAGACTGCA GTCTGCATTA GTCACCGGAG 360

GCTTACACAC AGGATGAAAG AAGCAGG AG T AGAC CATAGG CAGTGGAGGG GTCCCATATT 420

ATCCACCTGC AAGCAGTGCC CAGTGGTCTA TCCCAGCCCT GTTTGTGGTT CAGATGGTCA 4 80

TACCTACTCT TTTCAGTGCA AACTAGAATA TCAGGCATGT GTCTTAGGAA AACAGAAT CT 54 0

CGAG 544

(2) INFORMATION FOR SEQ ID NO:259:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 93 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:259:

GAATTCGGCC TTCATGGCCT ACATCAGCAT CCCTGGGAGC ATCAGAAATG CAGAGCTCAG 6 0

GCCCGCCCCG GAGCTACCGA ATCAGAACCT ACATTTTACA CACCCCTCAG CTCAGAGCTT 12 0

GTTTCTCCCT GGATTCCATG GCCCTGTGCT GCTGGCAGCC CGGGGTTAGG GCATTTCGTT 180

GTCACCTGGC GACGGTGAAG CCTAGTTTCC TCCAGAGAGA TTATGCTGCT CTCCATCCAA 24 0

GTGAAGTGGC AATGGTGCCA GCCTGAGATT TCTGCCCTGA GTTTTAAGTA CGAGAGTGTG 30 0

GGCTGACAAT AAACTCCTTT ATTCTACCCT CTTCTGTTCT CATAAGGAGA AATTTAAATT 360

CTGGAAGAGA TGAAGCTTGC ATTTACCCAA GAC 3 93

(2) INFORMATION FOR SEQ ID NO: 260:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 70 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26 0:

GAATTCGGCC AAAGAGGCCT AAGGGATTGT TATTCCTTTA AAAAAAAACC AATACCAAAG 60

AAGCCTACAA TGTTGGCCTT AGCCAAAATT CTGTTGATTT CAACGTTGTT TTATTCACTT 120

CTATCGGGGA GCCATGGAAA AGAAAATCAA GACATAAACA CAACACAGAA CATTGCAGAA 180

GTTTTTAAAA CAATGGAAAA TAAACCTATT TCTTTGGAAA GTGAAGCAAA CTTAAACTCA 240

GATAAAGAAA ATATAACCAC CTCAAATCTC AAGGCGAGTC ATTCCCCTCC TTTGAATCTA 300

CCCAACAACA GCCACGGAAT AACAGATTTC TCCAGTAACT CATCAGCAGA GCATTCTTTG 360

177

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GGCAGTCTAA AACCCACATC TACCATTTCC ACAAGCCCTC CCTTGATCCA TAGCTTTGTT 42 0

TCTAAAGTGC CTTGGAATGC ACCTATAGCA GATGAAGATC TTTTGCCCAT CTCAGCACAT 4 80

CCCAATGCTA CACCTGCTCT GTCTTCAGAA AACTTCACTT GGTCTTTGGT CAATG ACAC C 54 0

GTGAAAACTC GTGATAACAG TTCCATTACA GTTAGCATCC TCTCTTCAGA ACCAACTTCT 6 00

CCATCTGTGA CCCCCTTGAT AGTGGAACCA AGTGGATGGC TTACCACAAA CAGTGATAGC 660

TTCACTGGGT TTACCCCTTA TCAAGAAAAA ACAACTCTAC CTACC 705

(2) INFORMATION FOR SEQ ID NO: 2 61:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 72 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 261:

GAATTCGGCC AAAGAGGCCT ACCTTACTTG AGTCCACAGG CAAGGCCCAA TAATG CATAT 60

ACTGCCATGT CAGATTCCTA CTTACCCAGT TACTACAGTC CCTCCATTGG CTTCTCCTAT 120

TCTTTGGGTG AAGCTGCTTG GTCTACGGGG GGTGACACAG CCATGCCCTA CTTAACTTCT 180

TATGGACAGC TGAG CAACGG AGAGCCCCAC TTCCTACCAG ATGCAATGTT TGGGCAACCA 24 0

GGAGCCCTAG GTAGCACTCC ATTTCTTGGT CAGCATGGTT TTAATTTCTT TCCCAGTGGG 3 00

ATTGACTTCT CAGCATGGGG AAATAACAGT TCT CAGGGAC AG TC TACTCA GAGCTCTGGA 3 60

TATAGTAGCA ATTATGCTTA TGCAC C TAG C TCCTTAGGTG GAGCCATGAT TGATG GACAG 4 20

TCAG CTTTTG CCAATGAGAC CCTCAATAAG GCTCCTGGCA TGAATAC TAT AGACCAAGGG 4 80

ATGGCAGCAC TGAAGTTGGG TAGCACAGAA GTTGCAAGCA ATGTTCCAAA AGTTG TAGGT 54 0

TCTGCTGTTG GTAGCGGGTC CATTACTAGT AACATCGTGG CTTCCAATAG TTTGCCTCCA 6 00

GCCACCATTG CTCCTCCAAA ACCAGCATCT TGGGCTGATA TTGCTAGCAA GCCTGCAAAA 660

CAGCAACCTA AACTGAAGAC CAAGAATGGC ATTGCAGGGT CAAGTCTTCC GCCACCCCCA 720

ACACTCGAG 729

(2) INFORMATION FOR SEQ ID NO:262: .

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 686 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 262:

GAATTCGGCC AAAGAGGCCT ACTACCATGT CCTCTTGGAG CAGACAGCGA CCAAAAAGCC 6 0

CAGGGGGCAT TCAACCCCAT GTTTCTAGAA CTCTGTTCCT GCTGCTGCTG TTGGCAGCCT 120

CAGCCTGGGG GGTCACCCTG AGCCCCAAAG ACTGCCAGGT GTTCCGCTCA GACCATGGCA 180

GCTCCATCTC CTGTCAACCA CCTGCCGAAA TCCCCGGCTA CCTGCCAGCC GACACCGTGC 24 0

ACCTGGCCGT GGAATTCTTC AACCTGACCC ACCTGCCAGC CAACCTCCTC CAGGGCGCCT 3 00

CTAAGCTCCA AGAATTGCAC CTCTCCAGCA ATGGGCTGGA AAGCCTCTCG CCCGAATTCC 360

TGCGGCCAGT GCCGCAGCTG AGGGTGCTGG ATCTAACCCG AAACGCCCTG ACCGGGCTGC 420

CCTCGGGCCT CTTCCAGGCC TCAGCCACCC TGGACACCCT GGTATTGAAA GAAAACCAGC 4 80

TGGAGGTCCT GGAGGTCTCG TGGCTACACG GCCTGAAAGC TCTGGGGCAT CTGGACCTGT 540

CTGGGAACCG CCTCCGGAAA CTGCCCCCCG GGCTGCTGGC CAACTTCACC CTCCTGCGCA 600

CCCTTGACCT TGGGGAGAAC CAGTTGGAGA CCTTGCCACC TGACCTCCTG AGGGGTCCGC 66 0

TGCAATTAGA ACGGCACATT CTCGAG 6 86

(2) INFORMATION FOR SEQ ID NO:263:

178

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 571 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26 3:

GAATTCGGCC AAAGAGGCCT AGGAGAGAGG AGGTG CTGCA AG ACT CTCTG G T AG AAAAAT 6 0

GAAGAGGGTC CTGGTACTAC TGCTTG CTGT GGCATTTGGA CATGCTTTAG AGAGAGGCCG 120

GGATTATGAA AAGAATAAAG TCTGCAAGGA ATTCTCCCAT CTGGGAAAGG AGGACTTCAC 18 0

ATCTCTGTCA CTAGTCCTGT ACAGTAGAAA ATTTC CCAGT GGCACGTTTG AACAGGTCAG 24 0

CCAACTTGTG AAGGAAGTTG TCTCCTTGAC CGAAGCCTGC TGTGCGGAAG GGGCTGACCC 3 00

TGACTGTTAT GACACCAGGA CCTCAGCACT GTCTGCCAAG TCCTGTGAAA GTAATTCTCC 360

ATTCCCCGTT CACCCAGGCA CTGCTGAGTG CTGCACCAAA GAGGGCCTGG AACGAAAGCT 420

CTGCATGGCT GCTCTGAAAC ACCAGCCACA GGAATTCCCT ACCTACGTGG AACCCACAAA 4 80

TGATGAAATC TGTGAGGCGT TCAGGAAAGA TCCAAAGGAA TATGCTAATC AATTTATGTG 54 0

GGAATATTCC ACTAATTACG GACAGCTCGA G 571

(2) INFORMATION FOR SEQ ID NO:264:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 313 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 264:

GAATTCGGCC AAAGAGGCCT ACCAAGCAAG AACAGCTAAA ATGAAAG CCA TCATTCATCT 60

TACTCTTCTT GCTCTCCTTT CTGTAAACAC AGTCACCAAC CAAGGCAACT CAGCTGATGC 120

TGTAACAACC ACAGAAACTG CGACTAGTGG TCCTACAGTA GCTGCAGCTG ATACCACTGA 180

AACTAATTTC CCTGAAACTG CTAGCACCAC AG CAAAT ACA CCTTCTTTCC CAACAGCTAC 240

TTCACCTGCT CCCCCCATAA TTAGTACACA TAGTTCCTCC ACAATTCCTA CACCTGCTCC 3 00

CCCCATACTC GAG 313

(2) INFORMATION FOR SEQ ID NO: 265:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 343 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26 5:

GAATTCGGCC TTCATGCCTA GCCTCTGAGT TCAGCTCAGA ACACAGATGA TCTCATTGAT 60

TCCTCACGTC AAC CTTGGGA AATCTGGGTA CCCTGGGACG TCCACACATG AGGACCGAGG 120

CTCAGGGACA TCAAGGGACT GGCCTGGTCC CAGAAACAGG GAGTAAAATG GGAAGTAAAC 180

TCAGTCCCAC GTCTGCCTGA CTCCAGAGTT TGGGCCACTG AACCATGCGG CTGCCATCTT 24 0

GGAGTTCTTT GAGCTGTGAA GTGCTGTGCA TCGTGTGATT CTGTGTCCCT TTTGTGCAGG 300

TACCAGGATT TCTATGCATT CGACCTGTCA GGAGCCACTC GAG 343

179

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(2) INFORMATION FOR SEQ ID NO: 2 66:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 340 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 266:

GAATTCGGCC TTCATGGCCT ACAGGAAGCA CAGAAAGACA AAATTGGAAA TGTCTAGTTC 60

CATGTTGATG CCTTCAGAAG ATGCAGGTGA ACAAAGAGAG GCCGGGAAAT CAGAGCTAGT 120

TGAAACCCAA CATGTTACCT TAGAGCCAGA GCTACCACTG AGTTCTCTAA GCACAGTCAA 180

ATCCCAGGAT TATGCTGAAA CAGAGCAGGA GGTCATTTTA CAAGCTATAG AGGCCATGGA 24 0

GGCCACAGAA GCCCTGGAGG CCACAGACGC CATGGAAGCC AT AG AT CAAG GTAGCATGAA 3 00

AGATTATGGA GATG^GATCT CTAAGCTGGA AAGACTCGAG 340

(2) INFORMATION FOR SEQ ID NO: 2 67:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 367 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26 7:

GAATTCGGCC TTCATGGCCT AGGCACCCCT AGGCGACTCA GGGTTCGGGG AGGAGGAGAC 60

CAGACGGGGC CTTGGCTGGC ATGGCCTCTT CACAGGGCTG CCGTGAAGAA ACTTCGTGAC 12 0

AGCGG CGGAG AGGTGGCCCA GGAGTGAGAC AAGCAGGCCC CGGGCCTTGG ACTCAGACAT 180

GCTGGGTCCG GTCAGGCCCG TGTGGGAACC AGTGTTTTAG GGACTGGGTA CTCTCTTAGA 240

GAAGAACTGA TGCTAAAGAG TCAGGAAGAC ACGAGCGGGC CAAATAAAAG AGGAAGAGAG 300

GCCCTCAGGA CAT CATGG CA CTTACTGCTT GGATTTGTCT CCCCGTCCAG AATTCTGTGG 360

ACTCGAG 3 67

(2) INFORMATION FOR SEQ ID NO:268:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 320 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:268:

GAATTCGGCC TTCATGGCCT ACTTGGGAAT TAACATCTTC GATAAATCCC AGAAGTCTTT 60

AAGTGACAGT AGAGAGCCTA CAGAGAAGCC TGGGAAAGCA GAAAAATCTA AGAGCCCAGA 120

AAAAGTGTCA TCGTTCTCAA ACTCCTCCTC CAACAAGGAA TCAAAAGTAA ACAATGAGAA 180

GTTTCGTACT AAGAGCCCCA AGCCTGCCGA AAGCCCCCAG TCAGCCACTA AGCAGTTGGA 24 0

TCAGCCCACT GCTGCTTATG AGTAT TATGA TGCTGGCAAT CACTGGTGCA AAGACTG CAA 3 00

CACCATCTGT GGGACTCGAG 3 20

(2) INFORMATION FOR SEQ ID NO: 269:

180

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 542 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26 9:

GAATTCGGCC AAAGAGGCCT AGGGATATTT ACTGAGGGCC TACAGGGTGC CCAATACTGA 6 0

GCTAGCTAGG CTCAGGGACC TGTACACACA TGCATTCTCC AT TAG GGTT C TGCAATCCTG 120

ACACTATTAC TATCCTCAAG GACTCTGCGC ATCCAGACCC GTCTATTAGT TAG CAATG AG 180

AACCCCTGCC ATGG CCAAGT TACACAAGAA CACCCTTGCC CTACCTCTGC CCCCTGCNGA 24 0

TCTGAAAGTA ACCTGGTCTG AAAGAGAAGT AAAGATGTGG CTGTCCCTGG GTGCTAGGGA 3 00

GAGAGGCCTG TTGACAAAGC CACCAGCTGT CTCCAGTCAG AGCCAGGGAG ACAGGCTTCT 360

CCCTGCACCA TCCGCACTGC CATAGACACA GCAGCCAGCA ACAGCACTTG G AC CATTACG 420

GAGTTCCAGG CCCAGTCTCC AACTGACCTC CCTCCTGCTC CAGCTGCCCA TGCTAACAAG 480

AGCCAGGGCA CAAGACCTCA CTTGGAACAA GTACCAGGCA GAAGAGAGCA TNACCNGCCG 54 0

GT 542

(2) INFORMATION FOR SEQ ID NO: 27 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 613 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 270:

GAATTCGGCC AAAGAGCCTA GTCGATTGAA TTCTAGACCT GCCTCCTTTT CCACTTGAAT 60

TGTTAAATTG TTTACTCCAG CATCTTTAAG TATTCCTGTA ACCTGCTGTA CTATTCTTTG 120

TTCTAGCACA TCAGATGTCA CCTG TATATG AATTGTTCCT GCCACAATAC TAG CAG AATG 180

ACGCCAAAAA TGTGGGTCTC GGTATGATAT TAATCCTTCA ATTTTCTGTA TCTTTTCTAA 24 0

AG CAATATGT AGTTCTTTTT CATATTCTGG TGGCAATCTC AGG AG TAG AA CCTGGCAGGC 3 00

ATCTTTAATC AGTGGAACAA CACTGAGAAA TATTAATATA GCAATAAAAA GAGAACAGAG 3 60

TGGGTCAGCG ATGAACCATC CAAACTGCTC TATAAGAACT GTGGATACGA TCACACCAAT 4 20

GCTGCCAAGA GTATCTGCCA AAACATG T AG AAATACACCC CTCATGTTAG CATTCATGCC 480

TCCACCCGCA GATCCGTGGC TGTGACCATG CCCATGGTCA CTGTGTCCAT GCATATGATG 54 0

TGAATGGCTG TGATCAGATG AGTGACAGCT TCCTTGAGCC TAAACCGTCG ATTGAATTCT 600

AGACTGCCTC GAG 613

(2) INFORMATION FOR SEQ ID NO: 271:

(!) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 763 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 271:

GAATTCGGCC AAAGAGGCCT AGTCTGGTTC TTGCTTGATC TGAGAG CTTC CATCAGTCTC 6 0

TTTTATTTCT TCTGTGGCTG GAACTTCCAA CTGGCTTGGT TCAGCTGATT CTTGTATCAC 120

181

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GGGGCCTTCT GACTCACTCT GAT CAACCAG CTGGTTATTA AT CACAAG T C CTGGAAATGG 180

TCTAATGACC GTGAATTTGA TAAACTCGGC AG AG TC TAAG ATCCTTCTCA TGGAGCTGAT 24 0

TTCCAGGTAG CTGGGGGCTT TGAAAGGACA CCCCCGGGGG CATGCCATCA ACTACCACAC 3 00

AGCCAGGGTT AATTGTGATT TCCCTGTAGG GAACTTTCAC AGGAAAACCC ATACCAATAG 3 60

CTTCACCAAA TTTCCGACTA AAGAGGTCAT TCACTTGTTC TCTTAGCTGT CTAGCTTTTT 4 20

CAACTTTCGA GAGTCTTTCA TTATCATCAT CTGGAATTGT CACCTGAATG ATGTTAAGGT 4 80

CTTCAACACC TGATGCAGTA GTATTAACAT TGGGTGATGA ATTTATTTTT CTGGGAGGGC 54 0

TCTTAGAGGA GGTGCTCTCC TTAATCGCCG TCTCAAACAT TTCGGGCTTT TTAATGATGA 6 00

ACTTAATTTT GGCTTTGTTT CTGAGTATCT TCTCCAGCCT CGGAATGCCA AAAGTCGATG 660

GTCTTCGGAA TGGCACACCC TCAGGTAAGC CTTCCACATA AAAGTCTTCC GGGAAAGACT 720

CAAATAACGC GAACGGCACC TTCACAGCTT GTTTAAGGCC AAG 763

(2) INFORMATION FOR SEQ ID NO: 272:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 102 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO -.272:

GAATTCGGCC AAAGAGGCCT AATTAAGGAA ATACTTTGCA TAAATTAATC AGCCCCACAG 60
TATTTCCTTA ATAAGAATAA AATGAATTTA ACACTGATTC TG 102

(2) INFORMATION FOR SEQ ID NO:273:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 565 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 273:

GAATTCGGCC AAANAGGCCT ACNCCAGTCA AGGAAAGTCA AGTNGCAAGA AGGAANTGTC 6 0

TAAAAGAGAT GGCAAGGAGA AAAAAGACAG AGGAGTGACG AGGTTTCAGG AAAATGCCAG 120

TGAAGGGAAG GCCCCTGCAG AANACGTCTT TAAGAAGCCC CTGCCTCCTA CTGTGAAGAA 180

GGAAGAGAGT CCCCCTCCAC CTAAAGTGGT AAACCCACTG ATCGGCCTCT TGGGTGAATA 24 0

TGGAGGAGAC AGTGACTATG AGGAGGAAGA AGAGGAGGAA CAGACCCCTC CCCCACAGCC 3 00

CCGCACAGCA CAGCCCCAGA AGCGAGAGGA GCAAACCAAG AAGGAGAATG AAGAAGACAA 3 60

ACTCACTGAC TGGAATAAAC TGGCTTGTCT GCTTTGCAGA AGGCAGTTTC CCAATAAAGA 42 0

AG TTCTG AT C AAACACCAGC AGCTGTCAGA CCTG CACAAG CAAAACCTGG AAATCCACCG 4 80

GAAGATAAAA CAGTCTGAGC AGGAGCTAGC CTAT CTGGAA AGGAGAGAAC GAGAGGGAAA 54 0

GTTTAAAGGA ATAGGAAATC TCGAG 565

(2) INFORMATION FOR SEQ ID NO:274:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 188 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

182

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(xi) SEQUENCE DESCRIPTION; SEQ ID NO:274:

GAATTCGGCC AAAGAGGCCT ACTTAAATCA AGGCCAAAAC TAAGGATTTA GGTAGAGTGT 60

ATTAGCCTTT CAATACCTGC TTATTAAACA GTTGTTTTCA TACTTTTCAA AGGTGTGTAG 120

AAGTTTTGTA AATAAATTTT CTGATAGGAT AAACTAGATT CCCTATGATC TCTTATTTAT 180

TTATCATT 18 8

(2) INFORMATION FOR SEQ ID NO: 275:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 555 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID WO: 27 5:

GAATTCGGCC AAAGAGG C CT AGTCCGTGAT GCGTACACAC CTGTCGAGCA CGAGCTCCTC 60

TAGGCGGTGC AGGTCGCAGG CCACGTACTC CAGCGCCATG TCGGTGATNC GTGGGCACCA 120

CGAGAGGTCA AGGNTGCGCA GCTTGCGCAG GTTCTCGGCC ACGAGCTCCA CGCCGTCGTC 180

GGTGACCTTG GAGCAGCCCG AGAGG CTGAA CGCGGTGAGG TTGGGCAGGN TGTGCACCAC 24 0

GTTGACCACG CCGTGGTTGG TGATCTCCCA GCAGGAGAGC AGGCGCAGCG TGTGCGTGCT 3 00

GTGGCCCTGG CGCGCCGTGA AGTAGG CCAG CGCCGTGTCC GTCACGTGGT AGGCCTGCAG 3 60

GCTCAGCTCC GCCAGGTTGG GCAGCAGCTG CGAGATGGCC GCGATGGCGT CGTCGGCCAC 420

GTTGATGCAG TCACTCACGC TCAGCGAGGT GATGCGCGCG CTCAGGCTGG ACCACAGCCC 4 80

GGCCTCGGTG AAGTCGTTGC AGCCCGACAG CTCCAGACGC ACCACGCCCT GCATCTGTTC 54 0

AAGCATAACC TCGAG 55 5

(2) INFORMATION FOR SEQ ID NO: 276:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 96 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:276:

GAATTCGGCC AAAGAGGCCT ACAGTGAATA AT CAG AAGTC AGTTTGGGAG AAGTCAAAAT 60

GGACACAATC TTCTTGTGGA GTCTTCTATT GCTGTTTTTT GGAAGT CAAG CCTCAAGATG 120

CTCAGCTCAA AAAAATACCG AATTTGCAGT GGATCTTTAT CAAGAGGTTT CCTTATCTCA 180

TAAGGACAAC AT TATATTTT CACCCCTTGG AATAACTTTG GTTCTTGAGA TGGTACAACT 2 40

GGGAGCCAAA GGAAAAGCAC AG CAGCAGAT AAGACAAACT TTAAAACAAC AGGAAACCTC 3 00

AGCTGGGGAA GAATTTTTTG TACTGAAGTC ATTTTTCTCT GCCATCTCAG AGAAAAAACA 360

AGAATTTACA TTTAATCTTG CCAATGCCCT CTACCTTCAA GAAGG ATT CA CTG TGAAAG A 420

ACAGTATCTC CATGGCAACA AGGAATTTTT TCAGAGTGCT ATAAAACTGG TGGATTTTCA 4 80

AGATACAAGG CTCGAG 4 96

(2) INFORMATION FOR SEQ ID NO:277:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

183

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(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 277:

GAATTCGGCC AAAGAGGCCT ACACCCAGAG ACTGTAATTT GTGTAGTTTT TCTTTTTTAA
CTTAAAGACA ACTTTAAAAA ATACTTACAT TAATGTTTTT TATATTCATA GGTGGGTATA
TTCGCCTCAT TCAAATGGCA GTAGCCTTGG CTCACATAAG ACATGTTTCA TGTGATCTGT
ATCCTGGCAT AC CAGTTATA TTTTGTGGGG ACTTTAATAG TACACCATCA ACAGGAATGT
ATCATTTTGT CATCAATGGC AGCATTCCAG AGG AT CATGA AGACTGGGCT TCCAATGGGG
AGGAGGAAAG ATGCAATATG TCTCTTACAC ATTTCTTCAA G CTGAAAAGT GCTTGTGGTG
AACCTGCTTA CACAAATTAT GTTGGTGGCT TTCATGGATG T CTAG ATTAC ATTTTCATTG
ACTTAAATGC TTTAGAGGTT GAACAGGTGA TTCCATTACC TAG TCATGAA GAAGTTACCA
CTCCACTCGA G

60
120
180
240
300
360
420
480
491

{2) INFORMATION FOR SEQ ID NO: 278:

(1) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 9 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNE5S : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:278:

GAATTCGGCC AAAGAGGCCT ACAGAGAACA GATAAAAATA AGCCTGTGGA ATGACCACTT 6 0

TGTGGAATAC GGCAGAACCG TGTGTATGTT TCGCACAGAG AAGATT CGGA AGCTCGTAGC 12 0

CATGGGCATC CCTGAATCTT TGCGAGGGAG ACTCTGGCTT CTCTTCTCAG ATGCGGTGAC 180

GGATCTTGCC TCACACCCTG GTTACTACGG GAATCTGGTG GAGGAGTCCC TGGGGAAATG 24 0

CTGCCTGGTA ACCGAGGAGA TAGAACGAGA CCTGCACCGC TCCCTGCCAG AGCACCCCGC 3 00

CTTCCAGAAC GAAACGGGAA TTGCTGCTTT GAGGAGAGTC TTGACGGCCT ATGCCCACCG 36 0

GAGCTCGAG 369

(2) INFORMATION FOR SEQ ID NO: 27 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 79:

GAATTCGGCC AAAGAGGCCT ACTCTCCCTT TCCACTCCCT GGTGTTCCCA GGAG TGAGAT 60

GAGGGTGGAG GGGCCCAGCA CAGCACCTTC AAC CTCAGGA TGAGAG AGG C CCTTTCACAA 120

AACTCTAAGG CAGGGGAACA GGAAACAGAG AAAG CCGG AG AACCCCAGGA GGGCCCCAAG 180

AGCGGATTCT GGTGATTATT AATGTGCTTG CCCAATGAAG AAAGAATACT GGCACTCTCT 24 0

AGGTATGATG AGAGCAGACA GCAAACGTGG GGCCTGTCTA CAGTGATTCG CTACCCCAAT 300

GTATGGTCAT CCACGTTAGA AG CAGCAG TG AAAGGCGTGT TGCTTTTCAT TATTAACTTC 360

AAATCCCAGT CCCTAAACCA GCTCTTGACG CCCCTCTGTC AGGTGCTAAT CCTGGAAACT 420

GGAGGCCACC TGGTCTCCAC TTTAGGTGAG GAAAACCTGG GAGAAGCCAT CAGACTGCAC 480

CTGTGGCATG AG ATG CTTTG AGACAGGTCA AGAGGAGGAG CTCTCGAG 528

(2) INFORMATION FOR SEQ ID NO: 280:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 3 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 280:

GAATTCGGCC AAAGAGG OCT ACAGTGTCGG AGTAGATTTG AAACTGGAGG TGAAGGTAGG 60

AGTAAGTGAT AG ATT TT AGA ATTAGTGCTC AGAGCTGAAA TATCCAGTCC GTGAACT TAG 120

AGGCCAGCCT TCATACCACT GTGATGACAG GAACTACCCT AATCTTTTCT GTCCTTTTCT 180

CTCTGCTGTC CCTCGGGCTG CCAGGCCAGC AGCAACACCC ACAGGTAATC TCCCCGCTGA 240

CTCCATCCAC TTGCTCTGCC CTCTGCCCTC TCTGTGCCCC GTTGCACCTG AGCGTACACC 3 00

CCAGCAGTGG CATCCAACTC GAG 323

(2) INFORMATION FOR SEQ ID NO: 281:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:281:

GAATTCGGCC AAAGAGGCCT ACTCAGTCAG TACCATGCCA GTTACCTTTT TTCCTTGTGA 60

CTTAATGAAT TGGATTTTCC TCAATCTGTT ATTTGTAGGA GGTTTGTATG GGGCCAGGGT 120

AGATTTCCAG ATTTCTGCCT CAGAGGTAGT CTTTTTCACA TATGACACCT GGGTG TGTTT 180

CTCTGTGTGG CCACAAGTCT TCTGCCTCTC TAAAAAAATG TCTAGACCTT CTAGAAGGTC 24 0

TTTTGCCGCT AATTCTGAAC TTTCCACTCC TTCCTTTGCA GCTGTGATTG GAGGGACATG 300

GCTCCAGCAT GCCAATGTAA ACCACCGCCC CCTCGAG 337

(2) INFORMATION FOR SEQ ID NO: 282:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 194 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION :' SEQ ID NO: 282:

GAATTCGGCC AAAGAGGCCT AGGCTCTTCC ACTTAATTTC ATACTTTCAG GTCTGGATGC 60

CCATTTTAAT TCTTCTGAAA GCATGCCTCC TTCTGGCTTC AGGACTCCAT CTCCAGCCTT 12 0

ATGATCTAAA AATAATGGAA AATTACC CGG TATCGTTAGA GCTACACCAA AATTG CATTG 18 0

AGCCAAAACT CGAG 194

(2) INFORMATION FOR SEQ ID NO:283:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 96 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:283:

GAATTCGGCC AAAG AGG C CT AAAAT CATC A TATTCATAGA GATATTAAAA GTGCAAATAT 6 0

CTTACTGGAT GAAGCTTTTA CTG CTAAAAT ATCTGACTTT GGCCTTGCAC GGGCTTCTGA 12 0

GAAGTTTTGC CCAGACAGTC ATGACTAGCA GAATTGTGGG AACAACAGCT TATATGGCAC 180

CAGAAGCTTT GCGTGGAGAA ATAACACCCA AATCTGATAT TTACAGCTTT GGTGTGGTTT 24 0

TACTAGAAAT AATAACTGGA CTTCCAGCTG TGGATGAACA CCGTGAACCA CTCGAG 2 96

(2) INFORMATION FOR SEQ ID NO: 284:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 56 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 284:

GAATTCGGCC AAAGAGGCCT AGCAACATCC ACGCAG CTG C TC AT CAGGTA CGAGTGCTTC 6 0

CATATCCATT TACCCACCAT TGGCAATTTG AAAGGACCAT CCAGACCCCC ATAGGAT CCA 120

CATGGAACAC CCAGAGGGCT TTCCAAAAGC TGACTACTCC CAAGGTCGTC ACCAAGCCAG 18 0

GCCATATCAT TAACCCCATA AAAG CAG AAG ACGTGGGCTA CCGGTCTTCC TCAAGGTCGG 24 0

AC CTGTCTGT CATACAGAGG AATCCAAAAC GAATCAC CAC ACGTCACAAA AAACAGCTGA 3 00

AGAAATGCTC TGTAGATTGA GTTGCTGGAG GAGTGACAGC CAGGAGCCCT GACTTCACTT 36 0

CCTTTGGTCC AGTTTTACTC TGATACAGGG TGGAT TCCAA AACTGG CTCA GTACATTGCA 42 0

TGTAGTTAAG CCACATTTTA AAAATAAAGG CTCGAG 4 56

(2) INFORMATION FOR SEQ ID NO: 285:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 150 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 2 85:

GAATTCGGCC AAAGAGGCCT AAGGTCGGCC TGTTCATCTT G ATTAG CATC CAGGCCTTGG 6 0

AATATTTCAT CAATGACAGC TTTATCTTTG ATATTCTTGA TGGTGTTTGC AAGCTCCTTT 12 0

GTAAGCAGCT GCTTCAGCTC ACCCCTCGAG 150

(2) INFORMATION FOR SEQ ID NO: 2 86:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 115 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 286:

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AATCCAAGCA ATAACCCAAG CAAAACTTCA GATGCACCTT ATGATTCTGC AGATGACTGG 60
TCTGAGCATA TTAGCTCTTC TGGGAAAAAG TACTACTACA ATTGTCGAAC TCGAG 115

(2) INFORMATION FOR SEQ ID NO: 287:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 278 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:287:.

GGAAGAAGAT GCTAGGAGAA G ACT CAGATG AAGAAGAGGA AATGGATACC TCTGAAAGGA 60

AGATAAATGC TGGTAGCCAA GATGATGAGA TGGGTTGCAC CTGGGGAATG GGAGAAGATG 120

CAGTAGAGGA TGATGCTGAA GAGAACCCTA TTGTCTTAGA GTTTCAGCAG GAAAGGGAGG 18 0

CCTTTTATAT AAAGGATCCC AAAAAGGCTC TCCAAGGCTT TTTTGACCGA GAAGGAGAAG 24 0

AATTAGAATA TGAATTTGAT GAACAGGGAC AACTCGAG 2 78

(2) INFORMATION FOR SEQ ID NO: 2 88:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 364 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 88:

GGATTTCTGA GGCCAACTGC CCAATAGTTT CCAGTAGAAA CATGGCCATA CCAGTCTAGA 60

ATTTAACCTT CTCATTTAAT CAATAGCACA ATCTAACCTA CACAAGAATA AGCAATCAAA 120

CATCCAGTAT AACATGTTTT TCATTTTTAC TTTCTTGCGG TCAATTTTTT TAATGATCTA 180

TTTAAAATTT TTTCAAAATG ACAACTACTA TGGAATACTG AATACAAAGT TCAGTAACAC 240

AACATTGATA ACAACAACAG CAGCAACAAT ACCACAACCA CCACCACTGA ATGGTCTGGG 3 00

CACCTTCACA ATGGCTGTTG TACTTAGTTA CGAAGAAGAG TGGGGACAGA AAATGAAGCT 360

CGAG 3 64

(2) INFORMATION FOR SEQ ID NO: 289:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 71 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 89:

GACTCCATGC GTATGTCCCA CCTAAAGGTC GGCTCTGCTG CCGACATCCC CATCAACATC 60

TCAGAGACGG ATCTCAGCCT GCTGACGGCC ACTGTGGTCC CGCCCTCGGG CCGGGAGGAG 120

CCCTGTTTGC TGAAGCGGCT GCGTAATGGC CACGTGGGGA TTTCATTCGT GCCCAAGGAG 180

ACGGGGGAGC ACCTGGTGCA TGTGAAGAAA AATGGCCAGC ACGTGGCCAG CAGCCCCATC 24 0

CCGGTGGTGA TCAGCCAGTC GGAAATTGGG GATG CCAGTC GTGTTCGGGT CTCTGGTCAG 3 00

GGCCTTCACG AAGGCCACAC CTTTGAGCCT GCAGAGTTTA TCATTGATAC CCGCGATGCA 360

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GGCTATGGTG GGCTCAGCCT GTCCATTGAG GGCCCCAGCA AGGTGGACAT CAACACAGAG 42 0

GACCTGGAGG ACGGGACGTG CAGGGTCACC TACTGCCCCA CAGAGCTCGA G 471

(2) INFORMATION FOR SEQ ID NO: 2 90:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 281 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ix) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 290:

GAATTCGGCC TTCATGGCCT AGATTGAGTC ACATTGTTCT CTTTGATCCA TTTTCTTTTA 60

GACAACATCA CTCAAACAAC CCTATTACTT CAGTAGCAAT GAACTGTCTC TGGATT TTAT 120

TAAGCATCTC ACT.\GTTCCT TTTCTTCAGC TGTATGGCAC CCTGTCTTCC TGTACACCAG 180

AGGCTCCTCA GCTGGGTAAG GTGAGCCAAC GTTACCAGGA GTATATGCTG AGAGGCCATT 24 0

TCAAAGTCTT TCATAGAAGG CTGTGCTTGG GCAAACTCGA G 2 81

(2) INFORMATION FOR SEQ ID NO: 291:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 base pairs

(B) TYPE: nucleic, acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 291:

GAAACTCTGC CCCTGAAGGT TTGTTTTCTA ATTCAGAGGT TTAAATTAAT CTAGCCCACT 60

TAATAAAACC AGAGATCCTA TGGGAAATTT AG CCTAAG AC AGTG CTGGAA ATTGCCATAT 12 0

GTTGATACAA AGAAGTGTTT GGCCACATTA CAGGTCTCAG ACTCAACTGC TATGTGTGAC 180

TGCCGCTCTG TGCCTATGTC TTGCTTTTTT GCTGAGTTCC CTATTTCCAT ATCTCCAGGT 24 0

GATCCTCGAG 250

(2) INFORMATION FOR SEQ ID NO: 2 92:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 292:

GAAATGTCAG AGGCACATAA GCTTTTACAA AAATTGTTGG TTCATTGTCA GAAACTGAAG 60

AACACAGAAA TGGTGATCAG TGTCCTACTG TCCGTGGCAG AGCTGTACTG GCGATCTTCC 120

TCCCCTACCA TCGCGCTGCC CATGCTCCTG CAGGCTCTGG CCCTCTCCAA GGAGTACCGG 180

TTACAGTACT TGGCCTCTGA AACAGTGCTG AACTTGGCTT TTGCGCAGCT CATTCTTGGA 24 0

ATCCCAGAAC AGGCCCAACT CGAG 264

(2) INFORMATION FOR SEQ ID NO: 293:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 416 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:293:

GAATTCGGCC CTTCATGGCC TAGGTTTCTC CGTGTTGGTC AGGCTGGTCT CGAACTCCTG 6 0

ACCTCAGGTG ATCCACCTGC CTCAGCCTCC CAAAGTGCTG GGATTACAGG CATGAGCCAC 120

CATGTCCTGC TATAAATAAC TTTTAATAGG CTCTTTTTCT GGCTTTTTTT TTTAGTAACT 180

CAGCCCATTT TCTTCTTCTC AATCTGGTCT TTGTTAATGT TGATAACGCT GTCTTACTTT 24 0

TAAATTGCCG TGATTAGAAA TTACTAGAGA TATATAAACC TAGTCTTTTG GGGGATTTTG 300

AAAGGGTCAT AG TATTCTTA CTGTCTTTCA AAATGTACCT TATATTTGAA CATTGGAAGA 3 60

TACGTGTTGC TGAATACAAG TTAGTTTCAT ACACACACAT ACACATGACA CTCGAG 416

(2) INFORMATION FOR SEQ ID NO:294:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 458. base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:294:

GAATTCGGCC TTCATGGCCT ACTCCATTCC CAGATAGAAA GCTTGAATGA AGAGTTGGTC 60

CAGCTGCTTC TCATCCGAGA TGAGCTGCAC ACAGAGCAGG ATGCCATGCT GGTGGACATT 120

GAAGACTTGA CCAGACATGC TGAAAGTCAG CAGAAGCACA TGGCAGAGAA AATGCCTGCA 180

AAGTGAAAAG AAGCCATTCA ACCAGAGAAC AAGCTAGAAT TTATTTTGCT TCTGTGGTTG 240

TAAAAATGCT GTTGCTAAAG GTGGCGCAGA AACAAATATC AGTGTTAGTC ATTGATAATG 3 00

TCTGAAGCTT AATGTG CAGT GATTGG CCTT TGCTTCTTAA TTTATTTTAA TTTTTTACTT 3 60

GTGCCACTTA AT ATCAGG CA TTTTAATAAA ATATTGTTAC AAAAAATGTA CAGTACTGAC 4 20

ACCACCACAA ATCATGGTTA ATAAAAGAGA GT CTCGAG 4 58

(2) INFORMATION FOR SEQ ID NO: 295:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 02 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 95:

GTGTAAAACC AATGCCAGGA AAACCAAATA CACAAAACCC TCCACGGAGA GGTCCTCTGA 60

GCCAGAATGG GTCTTTTGGC CCATCCCCTG TGAGTGGTGG AGAATGCTCC CCTCCATTGA 120

CAGTGGAGCC AC CCGTG AGA CCTCTCTCTG CTACTCTCAA TCGAAGAGAT ATGCCTAGAA 18 0

GTGAATTTGG ATCAGTGGAC GGGCCTCTAC CTCATCCTCG ATGGTCAGCT GAGGCATCTG 240

GGAAACCCTC TCCTTCTGAT CCAGGATCTG GTACAGCTAC CATGATGAAC AGCAGTCTCG 3 00

AG 3 02

(2) INFORMATION FOR SEQ ID NO:296:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 412 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 296:

CATGGATCTG CCTCCTGAGA GGGATGGAGA GAAGGGGAGG AG C ACAAAG C CTGGCTTTGC 6 0

CATGCCAAAA CTTGCACTTC CCAAAATGAA GGCTTCTAAG AGTGGGGTCA GCCTGCCACA 12 0

GAGAGACGTG GATCCTTCCC TTTCTAGTGC CACAG CAGGG GGTAGCTTTC AAGACACAGA 100

AAAGGCCAGC AGTGACGGTG GTAGGGGAGG ACTTGGTGCA ACAGCAAGTG CCACAGGAAG 240

TGAGGGTGTG AACCTCCACC GGCCACAGGT CCACATTCCC AGTTTGGGCT TTGCCAAACC 3 00

TGATCTCAGA TCCTCCAAGG CCAAGGTGGA GGTGAGCCAG CCTGAAGCTG ACCTGCCTCT 360

TCCCAAACAT GAT CTGTCT A CCGAAGGTGA CAG CAGAGG A TGTGGGCTCG AG 412

(2) INFORMATION FOR SEQ ID NO: 297 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 08 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 297:

GTGCTGGTGG CGCGGGGAGT GCGCGTCAAG GTGAACGAGG CCTACCGGTT CCGCGTGGCA 60

CTGCCTGCGT ACCCAGCGTC GCTCACCGAC GTCTCCCTGG CGCTGAGCGA GCTGCGCCCC 120

AACGACTCAG GTATCTATCG CTGTGAGGTC CAGCACGGCA TCGATGACAG CAGCGACGCT 180

GTGGAGGTCA AGGTCAAAGG GGTCGTCTTT CTCTACCGAG AGGGCTCTGC CCGCTATGCT 24 0

TTCTCCTTTT CTGGGGCCCA GGAGGCCTGT GCCCGCATTG GAGCCCACAT CGCCACCCCA 3 00

ATCTCGAG 308

(2) INFORMATION FOR SEQ ID NO: 298:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 26 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 98:

GAATAAGTAA ATTCATGGAA AGGAAGAAAT TAAAAGAAAG TGAGGAAAAG GAAGTGCTTC 60

TGAAAACAAA CCTTTCTGGA CGGCAGAGCC CAAGTTTCAA GCTTTCCCTG TCCAGTGGAA 120

CGAAGACTAA CCTCACCAGC CAGTCATCTA CAACAAATCT GCCTGGTTCT CCGGGATCAC 180

CTGGATCCCC AGGATCTCCA GGCTCTCCTG GATCCGTACC TAAAAATACA TCTCAGACGG 24 0

CAGCTATTAC TACAAAGGGA GGTCTCGAG 269

(2) INFORMATION FOR SEQ ID NO: 299:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 58 base pairs

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(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2 99:

GAGCGACCTT TGGAATAGTT AAGCACAGGT CATTGTGGAC ATGAATTCAG GCCTCTGTAC 6 0

TAAAATCTAT TTCAGGGAAT GTTCTGTCTA GTGATTTGCT CACCATTTGA TATATAATGA 12 0

ATTATAGGAC AAGTATAAGC TGATCTGCTA TAGCTGTCCA TCAGAGAGAA TACACGTGGC 180

TATAACATCT ATAACAAAAC GACGATTCCT CTACAAGAGG CTGTTTCTCA CTGCTAACGT 24 0

TGGTGTTTCT GGCGTGGGAA GAAATGCACA GGCGTGCATG GCATGCACGT TCAGACAGCT 3 00

GCATTGTAAG AGTTCTGTCA TGCAGTCTGA AAAGGGAAGA AACAGGATGG CTTTCTGTAG 3 60

CCACACCTGT GAGGCGTGAT GATTGTTGTA TTATTAGATT ACTGATTTTT CTTTTCTGAA 420

AATACATTTG AGTTTTAATC ACATCTGTGG AACTCGAG 4 58

(2) INFORMATION FOR SEQ ID NO: 3 00:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 99 base pairs

(B) TYPE: nucleic acid

(C) STRAND EDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 3 00:

GGGATGCCTG TTCTTGGGGT AGAGAAGTCA GGTAGCCCAG GGCCCGCACT CTCAATAGAC 60
CTTCAGAGAA AAGGCATCGA GGTAAATGCC GCACTCGAG 99

(2) INFORMATION FOR SEQ ID NO: 3 01:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 569 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 301:

GGTCTAACAG TAACACTACT CAAGAGACCC TGGAAATAAT GAAAGAATCA GAAAAAAAAC 60

TGGTGGAAGA ATCTGTAAAC AAAAACAAGT TTATATCTAA GACTCCAAGT AAGGAAGAAA 120

TTGAGAAAGA ATGTGAAGAT ACCAGTTTGC GTCAGGAGAC ACAGAGGCGG ACATCTAACC 180

ATGGTCATGC CAGGAAAAGA GCCAAGTCTA ATTCCAAGCT AAAGTTGGTG CGTAGCCTGG 24 0

CAGTGTGTGA GGAGTCCTCC ACCCCATTTG CTGATGGGCC ATTAGAAACC CAGGATATAA 300

TTCAATTGCA CATCAGTTG C CCTTCTGACA AGGAGGAAGA AAAGTCCACA AAAGATGTCT 360

CTGAAAAGGA AGACAAGGAC AAAAACAAAG AAAAGATCCC AAGGAAGATG CTGTCCAGAG 420

ACTCCAGCCA GGAATATACG GACTCCACTG GAATAGACCT ACATGAATTT CTTGTAAATA 4 80

CACTGAAAAA GAACCCAAGG GACAGAATGA TGCTGCTAAA ATTAGAACAG GAGATTCTGG 540

AATTTATTAA TGACAACAAC CCACTCGAG 569

(2) INFORMATION FOR SEQ ID NO: 3 02:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 311 base pairs

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(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 302:

GCGATTGAAT TCTAGACCTG CCACCCAAAC CCCAACTCTC AGACTTACCT CCCAAACCAC 60

AGATGAAGGA CCTGCCCCCC AAAC CACAGC TGGGAGACCT GCTAGCAAAA TCCCAGACTG 120

GAGATGTCTC ACCCAAGGCT CAGCAACCCT CTGAGGTCAC ACTGAAGTCA CACCCATTGG 180

ATCTATCCCC AAATG TGCAG TCCAGAGACG CCATCCAAAA GCAAGCATCT GAAGACTCCA 240

ACGACCTCAC GCCTACTCTG CCAGAGACGC CCGTACCACT GCCCAGAAAA ATCAATACGG 3 00

GGGCACTCGA G 311

(2) INFORMATION FOR SEQ ID NO:303:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 83 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:303:

ACAGCATGAA GGCAGAAGCC AATGCCCTGC ATCACAAACA CGACAAGAGG AAGCGTCCGG 60

GGAAGAATGC ACCCCCAGGA GGTGATGAGC CACTGGCAGA OACAGAGAGT GAAAGCGAGG 120

CAGAGCTGGC TGGCTTCTCC CCAGTGGTGG ATGTGAAGAA AACAGCATTG GCCTTGGCCA 180

TTACAGACTC AGAG CTGTCA GATGAGGAGG CTTCTATCTT GGAGAGTGGT GGCTTCTCCG 240

TATCCCGGGC CACAACTCCG CAGCTGACTG ATGTCTC CG A GGATTTGGAC CAGCAGAGCC 300

TGCCAAGTGA ACCAGAGGAG ACCTAAGCCG GGACCTAGGG GAGGGAGAGG AGGGAGAGCT 3 60

GGCCCCTCCC CGAAGACCTA CTAGGCCGTC CTCAAGCTCT GTCAAGGCAA GCCCTGGACT 4 20

CGGAGGAAGA GGAAGAGGAT GTGGCAGCTA AGGAAACCTT GTTGCGGCTC TCATCCCCCC 4 80

TCCACTTTGT GAACACGCAC TTCAATGGGG CAGGGTCCCC CCCAGATGGA GTGAAATGCT 54 0

CCCCTGGAGG ACCAGTGGAG ACACTGAGCC CCGAGACAGT GAGTGGTGGC CTCACTGCTC 6 00

TGCCCGGCAC CCTGTCACCT CCACTTTGCC TTGTTGGAAG TGACCCAGCC CCCTCCCCTT 660

CCATTCTCCC AC CTGATCTC GAG 6 83

(2) INFORMATION FOR SEQ ID NO;304:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 53 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 3 04:

GAATTCGGCC AAAGAGGCCT AGAGATGTCT ACTCTCAGCT CACGCCTGTA ATCCCAGCAT 6 0

TGTGGGGAGG TCAAGTTGGG TGGATTGCTT GAGCCCAGGA GTTTGAGACC AGCCTAAGCA 120

ATAGG CAAAA CCCTGTCTCT ACAAAAATCA GCCAGGTATG GTAGTGTGTA CCTGTAGTCC 180

TAGCTACTCA GGAGGCTGAG GTGGGAGGAT CGCTTGAGCC TGGGAGGTGA AGGCTGAAAT 24 0

TAGCCATGAT CATGCCACTG CACCCCAAGC CTGGGCAACA GAGCAAGACC TTGTCTCAAA 3 00

AAAAAAAGGA TGAGCTAGGT TTGTATCTGT AGACAGAGAT TTATGATTAA TTGGTAGGTG 3 60

AAAAAG TGT A TTAAAGTACA GTTATAGATT AGAGTACAAA ATGAATGAGT ATATATGCGT 420

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TTAAAAGTAT GTATACATAT CAGGAAAGGT TACATGAGGA TTTTCACTTT CCACTTTATA
TCTCCCAGTA TTTGAATTTT TAATAACAAT CTTTTTATCA TAAAACTATA TTAAATTAAA
CTTTTAGATT TTTTAGTGGT ATAAG TAG AA CAGGAACCCT AATACATTGT TTTCTACTTT
TGTGATAAAG ATAATTCATG ATAGATGAAG TTGCAAACCG AAAGATCCTC GAG

4 80
540
600
653

(2) INFORMATION FOR SEQ ID NO: 305:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 442 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 305:

GAATTCGGCC TTCATGGCCT AAGGTATTCC AAAATGTCTA ATTTATTTTA TCCGATGGTA 60

AATGTAATAA TTAAAGAAAG AGGAAAGAAT CATGAAAGGT GGCCCTTAAA GAGGGCTTCT 120

GG C AG AG T T A GGTCAGAGGC ACACTTTCTT ACAGACTAAG AGTTTTTAAG TACTCAAGGT 180

GATGTTTATC AGAAGCTTGG ACTGCTTCTG TGTCTTTTTA TTGTGCTTAT CTGGGAGGGA 24 0

GAGTTCTGTG TCTGCTCCTA TACATCTTTC TGCAGCTGCA GACATACTCC CTGAGTCTGC 3 00

TTTTAGCTTT CCTATCTTAG TGCACCTGAA GGGAAAGGAA TGAGCTTATT AAGGCCCACT 360

GTTTTACTGG GGCCCATTGT ATGAGAGTGA AGTTTGG CAG TTACCCAAGA GACGTTCCCC 4 20

TCACCTCCCT CCGGCGCTCG AG 442

(2) INFORMATION FOR SEQ ID NO:306:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 412 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS ; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:306:

GAATTCGGCC TTCATGGCCT AC CAATATG C AAAT CAGTAC CTCTTCTCTT AGAGGTGTTC 6 0

ATGCCCAAGC TCCTCAGACA AGTCCATCCC ACTGTGTGGG AGGAAGTTGA AGGGTGAGGA 120

TTTTTAAGAT TTTTATCTTG CTTGAAGTTG TGAAGACTCA ATGACAAATG GCTAGGTTTT 180

GAAGGGGTCT TGGAAGTCAT TACTGGGGAT AGACCCCTCT TGATACTTGT CACATTAATA 24 0

TCTGCCCAGA CTCTCACACA TTCAGATGTT TAACGTCACA TGCATTAAGT TCTTTTGGTT 3 00

GCATGAGACA GTGATGCACA GAAACTCACT TAGGAAAGGA GATAGGTGGC AATAAAGAAA 360

ACAGGGATTT CATAGGAATG CAGTAAAAAA AAAACCATGG CCTAATCTCG AG 412

(2) INFORMATION FOR SEQ ID NO: 307:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 23 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 307:

GGGGTTGTCT GAGGCCCAGA GGT CGTATAA GGGCCGCTCT ACGGTGTCCT GGGGCCCGGG 6 0

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CTTGGCCCTT GTTGCAGAAG GGTTGAGGAG CCGGGCTGGG CCCTGCGCAC CTCCCGGGGC 120
AGCTCGCCCT GCTTGGCCAG CTTCTCCCAT AGCTGCTCCT TCCGCCTGAG CTTCTTGGCG 180
TTGGGGACCT GGTGGGCGAG GACGTCTTTG GGGGCAGGGA CTTTGGATGT GTTCTCGAG 23 9

(2) INFORMATION FOR SEQ ID NO: 30 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 53 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 308:

GCGCACCATC CTGGGAAGTG CATGTCTCAG ACCAACTCCA CCTTCACCTT CACCACCTGT 60

CGCATCCTGC ATCCTTCAGA TGAGCTCACT CGGGTCACAC CAAGCCTTAA CTCAGCCCCA 120

ACTCCAGCTT GTGGCAGCAC CAGCCACTTG AAATCCACGC CGGTGGCCAC ACCATGCACT 180

CCACGGAGAC TGAGCCTGGC TGAGTCCTTC ACTAACACCC GTGAGTCCAC GACCACCATG 24 0

AGCACATCCC TGGGGCTCGT GTGGCTGTTG AAGGAGCGGG GCATTTCTGC TGCCGTGTAC 3 00

GACCCCCAGA GCTGGGACAG GGCCGGCCGG GGCTCCCTCC TGCACTCCTA CACGCCCAAG 3 60

ATGGCTGTGA TCCCCTCTAC TCCGCCGAAC TCGCCTATGC AGACACCCAC ATCCTCCCCA 42 0

CCCTCCTTTG AGTTCAAGTG CACGAGCCCT CCCTACGACA ATTTCCTGGC TTCCAAGCCA 4 80

GCCAGCTCCA TCCTGAGGGA AGTGAGAGAA AAGAACGTCC GCAGGACCTC GAG 533

(2) INFORMATION FOR SEQ ID NO: 3 09:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 297 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 09:

GAATTCGGCC AAAGAGGCCT ACCCTAAAAC ATTTATTTCA AGGAGAAAAG AAAAAGGGGG 60

GGCGCAAAAA TGGCTGGGGC AATTATAGAA AACATGAGCA CCAAGAAGCT GTGCATTGTT 12 0

GGTGGGATTC TGCTCGTGTT CCAAATCATC GCCTTTCTGG TGGGAGGCTT GATTGCTCCA 18 0

GGGCCCACAA CGGCAGTGTC CTACATGTCG GTGAAATGTG TGGATGCCCG TAAGAACCAT 24 0

CACAAGACAA AATGGTTCGT GCCTTGGGGA CCCAATCATT GTGGCAAGAT CCTCGAG 297

(2) INFORMATION FOR SEQ ID NO: 3 10:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 24 B base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:310:

GAATTCGGCC AAAGAGGCCT AGGGTTTAAG AG CTGTGG AG GACTGAAAAC TGGATAAAAA 6 0

GGGGGTCCTT TTCCTTGCCC CTGTCTCTCA CTCAGATGCG CTTCTTTTTC GCCACTGTTT 120
GGCAAAGTTT TCTGTTAAGC CCCCAGTTCT CCAGGTGCGT TACTATTTCT GGGATCATGG 180

194

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GGTCAGTTTT AGGACACTTG AACACTTCTT TTCCCCCCTC CCCAGTTCTC CAGGTGCGTT
ACCTCGAG

240
248

(2) INFORMATION FOR SEQ ID NO: 311:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 343 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 11:

GAATTCGGCC AAAGAGGCCT AGGTAAATAA CTAATATTGA TGTATTTTTA TATTTTAATA 60

TAGACTAGTA AACTATGCAG AGTTAAGTGT TACATTAGAA TCTTGAACTC TCCTAACATT 12 0

TCTCTTCCTC AGTTTCCTAT TGTTTTGGTA GAGTATGTAG ACATTTG CGA GATTAATTTA 180

GAGTTGGTAG ATACATTCTG GATTTCATTT TACTTTAGAT AGCAGGTTTG GCACTTTAAA 24 0

TATATTTAAT TCAGTAAGAG AATAACTGAG TATGAGCTGT ATCCTCATCT TACTGTTGAA 3 00

GACATCCCAA ATAGTTGGGT GTGCACTGTG GCGGGATCTC GAG 343

(2) INFORMATION FOR SEQ ID NO: 3 12:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D>. TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 12:

GAATTCGGCC AAAGAGGCCT ACGGGGAGGC GCGCCCGCGC TGAGTCGGCG GCGGGTAGCC 60

ACTCCATGCC CTTGTCCGAT GGTTTGCAAC TCCGATTTTG CACACCGCTC CACCGTGCCC 120

CCCAGCGCAC ACCCATTCAC ACTCACGCCA ACACTCTCGC TGAACACTTT TATAATTGTT 180

AGGCGTGGCC GTTGGGACTT TGGGCGCAGC GCGGCTGATA CTGCGTCTGG AGGATTGATA 24 0

TTTACTTTTG CATTGCGGTT ACCTCGAG 268

(2) INFORMATION FOR SEQ ID NO:313:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 54 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:313;

GTCTCTCGCC GCCGGAGGAA GATGANGCTG AAGATTGGAT TCATCTTACG CAGTTTGCTG 60

GTGGTGGGAA GCTTCCTGGG GCTAGTGGTC CTCTGGTCTT CCCTGACCCC GCGGCCGGAC 120

GACCCAAGCC CGCTGAGCAG GATGAGGGAA GACAGAGATG TCAATGACCC CATGCCCAAC 180

CGAGGCGGCA ATGGACTAGC TCCTGGGGAG GACAGATTCA AACCTGTGGT ACCATGGCCT 24 0

CATGTTGAAG GAGTAGAAGT GGACTTAGAG TCTATTAGAA GAATAAACAA GGCCAAAAAT 3 00

GAACAAG AG C ACCATGCTGG AGGAGATTCC CAGAAAGATA TCATACTTCT CGAG 3 54

195

WO 98/45437

(2) INFORMATION FOR SEQ ID NO: 3 14;

PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 514 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO;314:

GAATTCGGCC AAAGAGGCCT AGTG CAAGAA CATGAAGCAC CTGTGGTTTT TCCTCCTGCT 6 0

GGTGGCAGCT CCCAGATGTG TCCTGTCCCA GGTGCACCTG CAGGAATCGG GCCCGGGACT 12 0

GTTGAAACCT TCGGACACCC TGTCCCTCAC CTGCTTTGTC TCGGGTTACT CCCTCAGTAG 180

TGTTCACTAT TGGGGCTGGA TCCGCCAGTC CCCAGGGAAA GGACTGGAGT GGATTGGGAA 24 0

CATCCATCAC AATGGTAGAA CCAATTACAA CCCGTCCCTC GCCAGCCGCG GTTCCATCTC 3 00

AGCCGACACG TCCaAGAACT CCCTCTCCCT GAATCTGACC TCTGTGACCG CCGCAGACTC 360

GGCCGTCTAT TTCTGTGCGA GCGGCCCTAT TGCCTCCTTT GAATCGACGA CTCTAAAGGT 4 20

GGGCGGAGAC TTTCACTCCT GGGGCCAGGG AATCCTGGTC ACCGTCTCCT CAGCATCCCC 4 80

GACCAGCCCC AAGGTCTTCC CGCACAGCCT CGAG S14

(2) INFORMATION FOR SEQ ID NO: 3 15:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 215 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 315:

GAATTCGGCC AAAGAGGCCT AGGACACTAG AATTATTAGT GTTCATTTTC ATCTAAGATC 60

TTTATTCTCT AACGTTCTTG GTCCTATTGA AACATTGCAG TATGCAAAAC TACTG CAATG 120

TTAAACCCAA GAGAAAAGCC ATTATCATGT GTATGCTGGT CATCATGATC AGTGTGGTAC 180

AATTTTTAAA AATAAACTAT CATGCCCTTC TCGAG 215

(2) INFORMATION FOR SEQ ID NO: 3 16:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 788 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 316:

GAATTATGTA CGCCCTCTTC CTCCTGGCCA GCCTCCTGGG CGCGGCTCTA GCCGGCCCGG 60

TCCTTGGACT GAAAGAATGC ACCAGGGGCT CGGCAGTGTG GTGCCAGAAT GTGAAGACGG 120

CGTCCGACTG CGGGG CAGTG AAGCACTGCC TGCAGACCGT TTGGAACAAG CCAACAGTGA 180

AATCCCTTCC CTGCGACATA TGCAAAGACG TTGTCACCGC AGCTGGTGAT ATGCTGAAGG 24 0

ACAATGCCAC TGAGGAGGAG ATCCTTGTTT ACTTGGAGAA GACCTGTGAC TGGCTTCCGA 3 00

AACCGAACAT GTCTGCTTCA TGCAAGGAGA TAG TGGACT C CTACCTCCCT GTCATCCTGG 360

ACATCATTAA AGGAGAAATG AGCCGTCCTG GGGAGGTGTG CTCTGCTCTC AACCTCTGCG 420

AGTCTCTCCA GAAGCACCTA GCAGAGCTGA ATCACCAGAA GCAGCTGGAG T CCAAT AAG A 4 80

196

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TCCCAGAGCT GGACATGACT GAGGTGGTGG CCCCCTTCAT GGCCAACATC CCTCTCCTCC 54 0

TCTACCCTCA GGACGGCCCC CGCAGCAAGC CCCAGCCAAA GGATAATGGG GACGTTTGCC 600

AGGACTGCAT TCAGATGGTG ACTGACATCC AGACTGCTGT ACGGACCAAC TCCACCTTTG 660

TCCAGGCCTT GGTGGAACAT GTCAAGGAGG AGTGTGACCG CCTGGGCCCT GGCATGGCCG 72 0

ACATATG CAA GAACTATATC AGCCAGTATT CTGAAATTGC TATCCAGATG ATGATGCACA 780

TGCTCGAG 78 8

(2) INFORMATION FOR SEQ ID NO: 317:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 214 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 3 17:

GAATTCGGCC AAAGAGGCCT AAATCATCCT GATGATGGTT TTCTTACATA AACATGAGCT 60

TCTGACCATG TACCATGGAT GGGTTCTCAC TTCCTGCTAT ATCCTGATCA TCACTATTGC 12 0

AAATATTG CA AATTTGGCCA GTACTGCTAC TGCAATCACA ATCCAAAGGG ATTGGATTGT 18 0

TGTTGTTGCA GGAGAAGACA GAAGCAAACT CGAG 214

(2) INFORMATION FOR SEQ ID NO: 3 18:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 267 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:318:

GTTGTCTTTT TTCCCCTTTA TAGCTGCTGG AGTGAATTTT AG AAAG CCTA AG TCATACAT 60

CACATTG CTT CATGGGCATC CCAG TACACT TTGGATTTTA TTTTACATCC TTACTGATCT 120

GATTCTCATC TCTGTCTCTT CATGGTTCTC TGCCTTCTAG TTACACTGGT GACCTTTCAA 180

AACCTTTACC ACATTGAGTT CATTCCTTAC TTTTCACTCT TTCTCTGCCT GGAGTGTTCT 240

GCCCCATCTT TACGTGGCAC GCTCGAG 267

(2) INFORMATION FOR SEQ ID NO: 319:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 256 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 319:

GAAGCTTTCA GGCTATCTTC TAGTCAAGAT GAGTGATAAG CCAGACTTGT CGGAAGTGGA 6 0

GAAGTTTGAC AGGTCAAAAC TGAAGAAAAC TAATACTGAA GAAAAAAAAT ACTCTTCCCT 120

CAAAGGAAAC TATCCAGCAA GAGAAAGAGT GTGTTCAAAC ATCATAAAAT GGGGATCGCC 180

TCCCAACAGC AGATTTCGAC ATTACCTGAG AGTCTTGATT TTAGGCTTGT TTTTTGTAAA 24 0

CCCATGTGTT CTCGAG 256

197

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PCT/US98/06956

(2) INFORMATION FOR SEQ ID NO: 3 20:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 304 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 320:

GCTGCGTGTG ATGGAGACCA AACCCGACAA GGCAGTGTCC AT CATTG AGT GTGACATGAA 6 0

CGTGGACTTT GATGCTCCCC TGGGCTACAA AGAACCCGAA AGACAAGTCC AGCATGAGGA 120

GTCGACAGAA GGTGAAGCCG ACCACAGTGG CTATGCTGGA GAGCTGGGCT TCCGCGCTTT 180

CTCTGGATCT GGCAATAGAC TGGATGGAAA GAAGAAAGGG GTAGAGCCCA GCCCCTCCCC 240

AATCAAGCCT GGAGATATTA AAAGAGGAAT TCCCAATTAT GAATTTAAAC TTGGCGCGCT 3 00

CGAG 3 04

(2) INFORMATION FOR SEQ ID NO: 3 21:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 298 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 321:

GAATTCGGCC AAAGAGGCCT ACTCTTACAC CTTCCGCTCC GTGGGCACCT TCAATATCAT 6 0

CGTCACGGCT GAGAACGAGG TGGGCTCCGC CCAGGACAGC ATCTTCGTCT ATGTCCTGCA 12 0

GCT CATAGAG GGGCTGCAGG TGGTGGGCGG TGGCCGCTAC TTCCCCACCA ACCACACGGT 18 0

ACAG CTGCAG GCCGTGGTTA GGGATGGCAC CAACGTCTCC TACAG CTGGA CTGCCTGGAG 24 0

GGACAGGGGC CCGGCCCTGG CCGGCAGCGG CAAAGGCTTC TCGCTCACCG TGCTCGAG 298

(2) INFORMATION FOR SEQ ID NO: 3 22:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 320 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 22:

GCGCCGTGTC CTTTTGCGTT GGTACCAGCG GCGACATGAC GGGGTACACT CCGGATGAGA 60

AACTGCGGCT GCAGCAGCTG CGAG AG CTGA GAAGGCGATG GCTGAAGGAC CAGG AG CTGA 120

GCCCTCGGGA GCCGGTGCTG CCCCCACAGA AGATGGGGCC TATGGAGAAA TTCTGGAATA 180

AATTTTTGGA GAATAAATCC CCTTGGAGGA AAATGGTCCA TGGGGTATAC AAAAAGAGTA 24 0

TCTTTGTTTT CACTCATGTA CTTGTACCTG TCTGGATTAT TCAT TATTAC ATGAAGTATC 3 00

ATGTTTCTGA AAAACTCGAG 320

(2) INFORMATION FOR SEQ ID NO:323:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 307 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 323:

GCAAAAATCT CAGGCCCCAG AAAAGCCTCT TGTCATCTCT CAGATGGGTT CCAAAAAGAA 60

GCCCAAAATT ATCCAGCAAA ACAAAAAAGA GACCTCGCCT CAAGTGAAGG GAGAGGAGAT 120

GCCGGCAGGA AAAGACCAGG AGGCCAGCAG GGGCTCTGTT CCTTCAGGTT CCAAGATGGA 180

CAGGAGGGCG CCAGTACCTC GCACCAAGGC CAGTGGAACA GAGCACAATA AGAAAGGAAC 24 0

CAAGGAAAGG ACAAATGGTG ATATTGTTCC AGAACGAGGG GACATCGAGC ATAAGAAGGA 3 00

ACTCGAG 3 07

(2) INFORMATION FOR SEQ ID NO:324:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 299 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 324:

GCACTTCTGA GAGGATGCTG GGAATCTGCA GGGGGAGACG GAAATTCTTG GCTGCCTCGT 6 0

TGAGTCTTCT CTGCATCCCA GCCATCACCT GGATT T ACCT GTTTTCTGGG AGCTTCGAAG 120

ATGGAAAGCC CGTGTCTCTG TCACCGCTGG AGTCCCAGGC ACACAGCCCC AGGTACACGG 180

CCTCCAGCCA GCGGGAGCGC GAGAGCCTGG AGGTGCG CAT GCGCGAGGTG GAGGAGGAGA 24 0

ACCGCGCCCT CCGCAGGCAG CTCAGCCTGG CCCAGGGCCG AGCCCCACCC ATCCTCGAG 2 99

(2) INFORMATION FOR SEQ ID NO: 32 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 325:

GAATTCGGCC TTCATGGCCT ACTCCAAACT CATGCCCTTG TTTTTATCTC TGCCCTTGGA 6 0

TGGCTGTCTT CTATTTTCAC TCACAATTTC AACACATTTT GACTTGCTCG TGTCACCTAG 120

GGTTTCCGCC TCAGGTATGT CTTCTTCCTT AATTTCTTTG CCGTCTTTGG TGCTGTTGAC 180

CTCACCCTTT CTGGGGTCTT CCTATTGGTC TCAGCTTCAG GTTTGCAGCC GCCCCTGGTT 24 0

TCCTGAACAT TCCTTCTGTG GGGTCTTCCC CTCCTTCTCA CCCACCCTCG AG 292

(2) INFORMATION FOR SEQ ID NO: 326:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

199

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 26:

GAATTCGGCC TTCAGACTTG AAGTGGAGAA GGCTACGATT TTTTTGATGT CATTTTGTGT 6 0

AAGGGCGCAG ACTGCTGCGA ACAGAGTGGT GATAGCGCCT AAGCATAGTG TTAGAGTTTG 120

GATTAGTGGG CTATTTTCTG CTAGGGGGTG GAAGCGGATG AGTAAGAAGA TTCCTGCTAC 18 0

AACTATAGTG CTTGAGTGGA GTAGGGCTGA GACTGGGGTG GGGCCTTCTA TGGCTGAGGG 240

GAGTCAGGGG TGGAGACCTA ATTGGGCTGA TTTGCCTGCT GCTGCTAGGA GGAGGCCTAG 3 00

TAGTGGGGTG AGGCTTGGAT TAGCGTTTAG AAGGGCAAAC TCGAG 345

(2) INFORMATION FOR SEQ ID NO: 327:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 474 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 327:

GAATTCGGCC TTCATGNCCT ACCTTTCCGT CCGTTCTTTC ACGCCTTCCT CCTCATTTTC 6 0

CTTCCTTCTA TTTTCCCTTC CCTCTTTCCG CTTTCCTGCC CCGTTTCCTT CCTCCCTCCC 12 0

TTCCTCCTTC CTTCCTTCCT CTGCGTTCTT CCTCTCTCCT TTGTTCCTTC CTCCTCCTCC 18 0

CCACTCCCTT TTCCTCTCCT CTTCCCACCC CAGTCTCCTA CTCCCCAGTC CTCCCATCCC 24 0

CATGGAACAT ACACCTGCTT TGTCTGGGAG CCACGTTATT CCTGCCAGCC AGACCCTGGC 3 00

CAGGAGGATC AGGGTCACGG TCAGCTTGGG CCGAGAACCC TTCACATGAG ACAAGCTCCT 36 0

CTGCCAGGGT TTCCTGTGGG AAAGGCCCCA CTTCCCGACC CTCCTGGGCC ACTGCATGGG 420

GTCCCCTCTT CGGCTTCTTC TCCCCTCTCC ACCCGGCAGC CCCCCCAGCT CGAG 474

(2) INFORMATION FOR SEQ ID NO:328:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 556 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 328:

GAATTCGGCC AAAGAGG CCT AATTTACTCC C CAAT AT AAA ACATTTTACC TGCGATCTAT 6 0

GTGTACATAT TGAATGATGT GTAACAATAT CATAATTTTT ATGTTCTGCA TTTTTTCACT 12 0

TATATATCTT TATTTAAATG GACTTAACTT TACTAATGGA GTAATTTTTA GCTTTCAGAA 18 0

GGAGTTCTCA CTCGAAGATA AAGAACAGCT CGCTAACCAC GAAAGAGGAA TCGATGCTCA 24 0

GCTTTTAGTT GCACTTCCTA AAGTTGCAGA ATTAAGACAA ATCTTTGAAC CAAAGAAGAA 3 00

AGAATTCTTA GAAATGAAAA GAAAAGAAAG AATTG C CAGG CGCCTGGAAG GGATTGAAAA 360

TGACACTCAG CCCATCCTCT TGCAGAGCTG CACAGGATTG GTGACTCACC GCCTGCTGGA 42 0

GGAAGACACC CCTCGATACA TGAGAGCCAG CGACCCTGCC AGCCCCCACA TCGGCCGATC 4 80

AAATGAAGAG GAGGAAACTT CTGATTCTTC TCTAGAAAAG CAAACTCGAT CCAAATACTG 540

CACAG AAACC CTCGAG 556

(2) INFORMATION FOR SEQ ID NO: 32 9:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 85 base pairs

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(B) TYPE; nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 329:

GAATTCGGCC
AAACAAAGCT
CCAACAAGTG
CTTTTTTTTT
CATCTCTCTT
CCCTAGAATG
CAAGGCCTTT

AAAGAGGCCT
AAGAAACAAA
AAGAATTGAA
GTTTTGCTCA
GTAAACTCAC
CAGGTGATTG
GCAGAAAAGC

ACAAAACCAT
GACTGAGGTG
CACCTTAATC
GCATATTGGC
CAAGTCTCAA
TTTATTTATG
TCGAG

CCATAAATAA
AGGGAGATTT
CATCTGATCT
ACAGTGAGAA
TAAGTTCACA
TATTTTCCTT

ACAAAGCTAA
GAGTATTTTT
CCCAGGTGGA
ATTCATTTTA
AAGAAGGCAG
GTTACATACC

GAAAGCTAAG
TTTTCCTCTA
AGCCACAAAT
TACTCTCTGG
AGACAAATAA
CACCTATACC

(2) INFORMATION FOR SEQ ID NO: 3 30:

<i) SEQUENCE CHARACTERISTICS :

• (A) LENGTH: 6 96 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:330:

GAATTCGGCC
CTCGGTAATC
GGGGTCGTGA
CTTGGCCATG
AGGAGTGGCT
CGAATTCTCT
GTCACCTTCC
GTGACGATCA
GGGTCTGGCA
CCTGGTAGAT
GCTCCGGGCC
GTGACCGTCA

AAAGAGGCCT
ACAACAAACA
CGATTCTTTT
ATTCTGTCTT
TGCCAAGCAG
CTCCACACGC
ACTGGCGGCT
TCTCATTCAC
GAACAACTTC
ATGAAGTGCT
CCGAAGGTCT
GGGAAGATGC

AGGAAGCAGG
CGGAGCAATC
CTTCTTGAAG
TTCAATGACT
CGTGAAGTTG
AAGGTCTAGT
GGCAAAGTGC
TTTCTTCACG
TGGCCAAGGT
CTGTGAATTG
CAGGATG CTG
TGCCATGGCC

AGTTTATTTT
TCAATGCTGT
TTTTTCCTTT
GTGGCTTCTA
TCTGCCCCAA
TCATTTCCAA
ACCACGGCAA
ACCTCTGCAT
GGTGAACTCA
AACCTTCGAG
TGGCTGCACG
GCCGCC

TATCCTTTTG
TTATCCGGAG
TCCTGAATCT
CTCGAACAAG
CCAGCAGGAC
TTAAG AT CAG
AGAGCCTGCC
GGTGTCTGGT
GGGATGTTTT
AAGCAGACCA
CGGACGCCAG

TAAGTATTAA
GACAGTCTGC
CATAATGATT
ATCCTTTCCG
CTTCTCCAGT
GTCTTCAGAG
ATACTGCCCC
CTCCTCAACT
AGGAACATAT
AAGGGAGGCT
CCGCCCTAAG

(2) INFORMATION FOR SEQ ID NO: 331:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 78 base pairs

(8) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 31:

60
120
180
240
300
360
385

60
120
180
240
300
360
420
480
540
600
660
696

GAATTCGGCC
ATTATATGTC
GTGTGTGTGT
CCATGGCTGT
GGAGGGGAAG
CATGGAGCCA

AAAGAGGCCT
TCTGTCTCTC
GTGGTGCAGG
CTGCCTGCGT
GAGCCGCCCT
GACCGGGTGG

AATTTTTTGT
TCTATTGTGT
AGTGCCACCC
ATCTGTCTCT
CCCTATCTTG
AGGGGCTTCT

ACATCTGGGC
GTGTGTGTGT
CCAGGGCCCT
GAGAATCCTC
CTGCTCCTCT
GGGATTTGGT

CCTTAGTTTT
GTGTGTGTGT
GTCAACCTCT
GGGGCGGTCA
TGGCACTCAG
GTCTGCTGCT

TATTCTGTTT
GTGTGTGTGT
CTTTTCTCCT
GGGGATGTCA
GGGCACCTTC
GCCAGAGCAG

60
120
1B0
240
300
360

201

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GAACCCCCAG TACTCGAG 378
(2) INFORMATION FOR SEQ ID NO: 332:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 94 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 3 3 2 :

GAATTCGGCC TTCATGGCCT ACATTGGGAT TATTGGTGCT GTGACCATGG CTGGCATCAT 60

GGCGGCAGAC AGAAGTGAAT CACCTAGTTT GACCCAAGAG AGAGCCAACC TGAGCGATGA 120

GCAG TGCACA CAGGTGACCT CCTTGTTGCA GTTGGTTCAT TCCTGCAGTG AGCAGTCTCC 180

TCAGGCCTCT GCACTTTACT ATGATGAATT TGCCAACCTG ATCCAACATG AAAAGCTGGA 24 0

TCCAAAAGCC CTGGAATGGG TTGGGCATAC CATCTGTAAT GATTTCCAGG ATGCCTTCGT 3 00

AGTGGACTCC TGTGTTGTTC CGGAAGGTGA CTTTCCATTT CCTGTGAAAG CACTGTACGG 360

ACTGGAAGAA TACGACACTC AGGATGGACT CGAG 3 94

(2) INFORMATION FOR SEQ ID NO:333:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 7 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
<D> TOPOLOGY: linear

{ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 333:

GAATTCGGCC AAAGAGGCCT ACTTATTTTC CTGTGAAAAT GCCTACCACA AAGAAGACAT 60

TGATGTTCTT ATCAAGCTTT TTCACCAGCC TTGGGTCCTT CATTGTAATT TGCTCTATTC 120

TTGGGACACA AG CATGGATC AC CAG TACAA TTGCTGTTAG AGACTCTGCT TCAAATGGGA 180

GCATTTTCAT CACTTACGGA CTTTTTCGTG GGGAGAGTAG TGAAGAATTG AGTCACGGAC 24 0

TTGCAGAACC AAAGAAAAAG TTTGCAGTTT TAGAGATACT GAATAATTCT TCCCAAAAAA 3 00

ACTCTGCATT CGG TGACTAT CCTGTTCCTG GTCCTGAGTT TGATCACGTC GCTGCTGAGC 36 0

TCTGGGTTTA CCTTCTACAA CAGCATCAGC AACCCTTACC AGACATTCCT GGGGCCGACG 420

GGGGTGTACA CCTGGAACGG GCTCGGTGCA TCCTTCGTTT TTGTGAC CAT GATACTGTTT 4 80

GTGGCGAACA CGCAGTCCAA CCAACTCTCC GAAGAGTTGT TCCAAATGCT TTACCCGACT S4 0

CCTCGAG 547

(2) INFORMATION FOR SEQ ID NO:334:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 97 base pairs

(B ) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:334:

GAATTCGGCC TTCATGGCCT AGGGGAAATT GAGTCAAGAA AAGGTTCAAT ATTTTTTAAT 6 0

GGTAGAATTG ACCGTATGTG TATGTGCTTC TAGAAG TG AT TCAGGAGAGA GGGTGGAATG 120

202

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GATGGTGTGG GACGGAGGGA AGAATTGGTG GAATGATGTT GGCAAAAAGG AATAGGCTTT 180

TGTGCATAAG TTGAGGGATT GGCCTTGCCT AGAAACATGG ACAATTCGTC TATAGTAAGA 24 0

AGAGAAAAGG TAGATCTATG ACCACAGACA TAGTCAGATA ATCATTTTAA AATTCTTTAA 300

TCAATAGATG TTTCTGATGT ATGGCAGGCA GTAAGCTAAG CAGTTTACAT ACCTGATTTC 360

ATTTAGTTAT TATAACAATC CCAGTCTAAA ACTCGAG 397

(2) INFORMATION FOR SEQ ID NO: 33 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 313 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 335:

GAATTCGGCC TTCATGGCCT ACTCCATCCT TAAGGTCACC ATTGGTATGT TCCTGCTCTC 60

TGGAGATCCC TGCTTCAAGA CGCCACCATC GACTGCCAAG TCCATCTCCA TCCCAGGCCA 120

GGATTCCTCC CTGCAGCTGA CGTGTAAGGG TGGTGGGACC AGCAGTGGGG GCAGCAGCAC 180

CAACTCCCTG ACTGGGTCCC GGCCCCCCAA GGCTCGGCCC ACTATTCTCA GCTCAGGGCT 24 0

GCCAGAGGAA CCCGACCAGA ACCTGTCCAG CCCTGAGGAG GTGTTCCACT CTGGCCACTC 3 00

CTCGCAACTC GAG 313

(2) INFORMATION FOR SEQ ID NO: 33 6:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 67 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 33 6:

GAATTCGGCC AAAGAGG CCT AGATTGAATT CTAGACCTGC CTCGGCCTCC CAAAGTGCTG 6 0

GGATTACAGG CTTGAGCCAC CACACCTGGC CTAGTGATTT GTAATTTCAT GAGCTGTTGC 120

TGTATTGCCT T CCACAGACA GTCAATTTAT AATCCCTCAG TATTATATAA TCAGGAAGAT 180

TCAGTGAATG GAATTTTGGG TTGGTGGAGG ACATATTTTT TAATTGGTAG AC CACTGAGT 24 0

GCTTTTG CAA ATCTCCTTAA ATCACATTAC AGCAGGAACA ACTATAGAAA ATACAATTAT 3 00

TTAGGAG CAA CCTGATCTGT G AG CTAATTT AATGAGTGGA GCCCAGCCTA CATGCTGAAG 36 0

AGCTCACATG CCTCCTACCT AGTTCCTTAA CTAGGTTTTC ACTCATGCCC ATTTTGTCAT 420

ACTCTTGAAA CCTTCCTATC TTTGCATAGA ACATTATTCT TTCCACT 4 67

(2) INFORMATION FOR SEQ ID NO: 3 37:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 33 7:

GAATTCGGCC AAAGAGG CCT ACTTCTTTGA AG AAC CATGA AGTCACACTA TATTGTGCTA 6 0

203

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GCTCTAGCCT CCCTGACGTT CCTGCTGTGT CTCCCCGTGT CCCAGAGCTG TAACAAAGCA 120

CTCTGTGCCA GCGATGTGAG CAAATGCCTC ATTCAGGAGC TCTGCCAGTG CCGGCCTGGA 180

GAAGGGAACT GCCCCTGCTG TAAGGAGTGC ATGCTGTGCC TCGGGGCCCT GTGGGACGAG 240

TGCTGCGACT GTGTCGGTAT GTGCAACCCT CGGAATTACA GCGACACCCC GCCCACATCC 3 00

AAGAGCACCG TGGAGGAG CT GCACGAGCCC ATTCCGTCCG CTGTCGAG 34 8

(2) INFORMATION FOR SEQ ID NO: 33 8:

(i) SEQUENCE CHARACTERISTICS !

(A) LENGTH: 259 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 38:

GAATTCGGCC TTCATGGCCT AGCCAGTCTT CAGTTATAAC CACTCCACCC TCCTCACTTT 60

CTCTCTCTCT CTCTCTTTTT TTTTTTTTTT TTTTTTGCTA TGGGATTTAA TGGGAAAAAT 120

ATGTAAAAAC TGTCACTAGT CAGCTGGCTC TTTTTCCTAT GAAATCTATC AGTACCTTTC 180

TCCATCCGTT GTTCTCAATA ATGACCACAG AGCCTGAGTA TACCAAGAAA ACCAATATTC 24 0

GCATTACAGG TCACTCGAG 25 9

(2) INFORMATION FOR SEQ ID NO: 33 9:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 183 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 33 9:

GAATTCGGCC AAAGAGGCCT AGCCTTCTGC AAGATGCTTC TGATTCTGCT GTCAGTGGCC 60

CTGCTGGCCT TCAGCTCAGC TCAGGACTTA GATGAAGATG TCAGCCAAGA AGACGTTCCC 120

TTGGTAATAT CAGATGGAGG AGACTCTGAG CAGT T CATAG ATGAGGAGCG TCAGGGACCA 180

CCT 183

(2) INFORMATION FOR SEQ ID NO:340:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 64 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 340:

GAATTCGGCC TTCATGGCCT AGTTTTAACT GAGTGCAACA AGTATTTTCG TTAAGAGATT 60

TTTTTTCGTA ATTTACCATT CTGCTGAATC AATTTTTAAT CCAGTTGGAA GCTCTAAAAT 120

TCTAACATAA TTCAGAAGCA TTAAAAAAGA AGACTAAGGA AGAGAAAGCT ACATTTTTAT 180

TTCAGCTTGT ATTGCATTGT G C AGAAAGG A AAATAGTCTA GCTAATTTAC TTTTCCTATG 24 0

AAAAACCTTA GAAGGCTCCT CGAG 264

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(2) INFORMATION FOR SEQ ID NO: 34 1:

U) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 412 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 41:

GAATTCGGCC TTCATGGCCT AGCCTTTCTA GTCTTCCCTC TTCTGTAGGA ATANCATGTT 60

CCTCAAATGG TCCTGAACTT TTTCACCATT TTGGTGAACC CTTTTAAAGT AAATTTACTC 120

AATGCTTTAA AATTCATAGT CTTAAAATAA AT GTGAATT T TGTTTCCAGG TATTTATTCT 180

GGGGTACAAA AACTTCCCAG AATTTACAGT AGGAAAGGAA ACCCCTTTAT GATGTGGCTT 240

ATTATTACAA GCATTCAGAA ATGATGCTGG CTAAGTCAAA TCATTCCTTG AGACAGTGAT 3 00

TCCTAAATGT AATGCCGCCT TCCTGAACTC TCACATATTC TATATCATGG TTATTTTAAA 3 60

AAATATATTT TTAGCCTTTT GTAACCTTAG TCTTGTTTTG AGCAATCTCG AG 412

(2) INFORMATION FOR SEQ ID NO: 342:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 66 base pairs

( B ) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 42:

GAATTCGGCC TTCATGGCCT AGGGATTATA GGTGTGAGCC ACCGCGCCCG GCCAGGAATC 60

ATTTTTATCC AGGTAAGGCA TACAGAACCG GAGGGTTCTT GTCTAAGTTG TACCATGAAT 120

GTGTGCTCAG TGGCTACTTT GAAATAGACT TACTGTACAA TCCCTGAGCA GGAATGAAAA 180

TAAAAGCTGG AAATCACGGG TTGCTCTGGG GTTTTCAGGA AGGTGTCGTC CGTCTGGGGT 240

GAGTGTCCTC CTTTCTCANG GGAT TTCATG TGGCATTATT TTGTTTTCAT CTGAGAGGCA 3 00

ACATAAGCTG GGAGGGAAGG GCTGCAAAGA GGGGGCCAGG ACAAATGTGT ACCTGGGGGC 3 60

CCCCATTTTG ACTCCACCCT GAGCTGGGGC TGGGCCACAG GAGGGCAGAG GGAACACTTT 420

GGGACGGGGA GGGAGCCCCT GGACTGAAAG AATGGGGTGA CTCGAG 4 66

(2) INFORMATION FOR SEQ ID NO: 3 43:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 28 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 34 3:

GAATTCGGCC TTCATGGCCT AGAATTTTGG AGTCTTTATC ATAGGTAACC TGGACCACAG 6 0

TTACTATTTA TTGACAATGT GATTGAGTGT ATGGAGGAAA GCACAGTGGA TGCTAGGCTT 120

TGTAAATATG GGGATGTAGA AAAGCAGATA GTTCAGTGTC TACCTTTTTC TAGAACTACC 180

TTGAACCTTA AATTTTAAGT CATGTTCATT GCTAGAAAAT TAAATGTACT TATTAAAACC 24 0

AATGAAAAAG CACATTTCTG AAATGAAGTT AG AGATAAT C TCTGTGTCTT ATAAAAAGAC 300

ATTAATAAAA ATCTGGTAAG GACTCGAG 32 8

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(2) INFORMATION FOR SEQ ID NO:344:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 416 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 344:

GAATTCGGCC
TAAAAAAGTA
TCAATGTTCC
TGTCAAGAAA
ATTTTTATTA
AGGTCTTGTA
ACAGAATGCT

TTCATGGCCT
TACAAGGCAG
CACTAATATT
ATAAACAGAT
AGATTGAACT
TTTATAAAGT
TTGAGCTCTT

AGTGACCAGA
AGTTGCAAAC
TTCCATCCGT
GTGCACCACA
TTTGATGTTG
TATCTCCTAT
TCTAGTAGAT

CATAAGAACT
AATCTCAGCC
GTACTGAGTG
AG CGG AACAA
ATTCCACTGG
TGAGGAAGAT
CTGTGCCAAC

CATTTTTAGT
TATGAAAAGG
AATTTGTAAT
CAATGAAAGA
TAAGAG AG C A
GAAGATGTCA
T CTGAAACAC

TAAAGCATTT
AC AG CTG CAG
GTGCAACTCA
ACTTACATAG
CTGTAGGCAA
ATACTCCCCA
CTCGAG

60
120
180
240
300
360
416

(2) INFORMATION FOR SEQ ID NO: 345:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 344 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 34 5:

GAATTCGGCC
TGATGATTAT
TTTTTAATAA
TTTTTTTAAA
AACAGGCAAG
ACCTAACTTT

TTCATGGCCT
ATTCCTGGTT
GTGAAATAAC
TAGAAGTGTG
TCATTTCCTA
GATTTTAGTG

AG TAAATACA
CAGTTTTTCT
TGGTGACTGT
AAAAGAAACT
TCTTTTTATA
GGAGTATGTG

AAATACAAAA
TCCTGAGAAA
GTTGTATGTG
TCATCCACGG
ATCTCTGCCT
AGCTGTGACT

ATACTGGTGA
TTTGATAATA
TGTGTGTGTG
AAACTTCAGG
TGTGGGATTT
CGAG

GAGAATGGGA
CATCTTTTGA
TTTTTTTTTT
ATAATTTTGA
GGTTTGGTTT

12) INFORMATION FOR SEQ ID NO: 34 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 544 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 3 46:

60
120
180
240
300
344

GAATTCGGCC
GCGGGGCGCA
GCGCGTTAAA
GGTTAAGTCA
GAGAAGGAG C
TAAACTCCTC
TCCTCCAGCC
CCCGGGGGCC

TTCATGGCCT
CCAGGCCGAA
CCAGGGAGTC
GAGGATG CTG
TGGAGACCTA
GACTCCCAAG
TCACCTTCCT
TCAGAACTAC

AGCCTTCGGA
GGCTCACGCC
CTGGAAGGGG
GACAT CTCGG
GTGGCGCCTG
GCCCCAGCTC
CCAGCCTCAC
CCCTTCCAGG

ACCCCACCAG
ACAGGGAGGG
ACGACGCCCC
GGGACCGGGG
ATGCTTCGGT
CATCTTTACC
CACTCCTCCC
GCCTCAGAAC

AGTCACAGCC
CAGCTAGGAC
CGGCCAGTCC
CGTGCTGAAG
GCTAGATGCT
TCAGAG CCTC
TGGACCTGCA
TACCCCTACG

AGGAAGGGCA
ATGGGGGGAA
CTGTACGAGC
GACGTCATCC
TCGTCTTGGG
CTGAACCTCC
GCTCCGCACC
GTTTCTCCTG

60
120
180
240
300
360
420
480

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CGTAACCTTC TGCCTACCTT CCTGAGAGTG GTTGGTGACA GCAGCCGGGG CTAGAAACCT 540
CGAG 54 4

(2) INFORMATION FOR SEQ ID NO:347:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 570 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 347:

GCCTTCATGG CCTACCCAGT GATTGTCACC ATGGCCAGCA AGAGGAAATC CACCACACCA 60

TGCATGATCC CAGTGAAGAC TGTGGTGTTG CAAGATG C C A GCATGGAGGC CCAGCCCGCT 120

GAGACCTTGC CTGAAGGACC CCAGCAGGAT CTGCCCCCAG AAG CAT CTG C TGCCAGCAGT 18 0

GAGGCAGCAC AGAACCCCAG CAGTACTGAT GGCTCTACAC TGGCCAATGG GCATCGGAGC 24 0

ACTTTAGATG GCTATTTATA TTCCTGTAAA TACTGCGATT TCAGATCCCA TGACATGACC 300

CAATTTGTGG GACATATGAA CTCAG AG CAC ACAGACTTTA ATAAAGACCC AACCT TTGTA 360

TGCAGTGGGT GCAGTTTTCT GGCAAAAACC CCTGAGGGGC TTTCCTTGCA CAATG CCACA 42 0

TGTCACTCCG GGGAAGCCAG CTTTGTGTGG AACGTGGCCA AGCCAGACAA TCATGTGGTT 480

GTGGAGCAGA G CATCCCTG A GAGCACCAGC ACTCCTGACC TAGCGGGTGA GCCCAGTGCT 54 0

GAAGGGGCTG ATGGACAGGC AGAGCTCGAG t 57 0

(2) INFORMATION FOR SEQ ID NO: 34 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 00 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 34 8:

GAATTCGGCC TTCATGGCCT AGAAAAAAGT TTTCAAAGGG AAGTAATCTT AAATC TG TAT 60

ACTATTTTCT ATGATGGAAA TTCTGTGAAG AAACAATAAC AAATTCTCCC TGACTCCTGT 120

CTGTCCTAAT AGTAAGGTGG TCTTTCTTCT AATCTCCCCA TCCATCCACC CAT CAGGAAG 180

CAACAGGGTA CCTTGTGTGA GTAACTGTAG ATTTCTGACT TCTTCTCGCA CCTTCAGCTG 240

GAGCACCTGT TGTAAGATGT GCTGCCGGAG GTTCTCCTGG GCAATCCCCA TTCGCTCGAG 300

(2) INFORMATION FOR SEQ ID NO: 34 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 34 9:

GAATTCGCCC TTCATGGCCT AACAACCACC ACCACCTGGA CGCCCAGCAG CACAACCACC 60
ATAGCCGGCC TCAGGGTCAC AGAAAGCAAA GGG CACTCAG AATCATGGCA CCTAAGTCTG 120
GACACTGCCA TCAGGGTTGC ATTGGCTGTC GCTGTGCTCA AAACTGTCAT TTTGGGACTG 18 0

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CTGTGCCTCC TCCTGTGGTG GAGGAGAAGG AAAGGTAGCA GGGCGCCAAG CAGTGACTTC 24 0

TG AC CAAC AG AGTGTGGGGA GAAGGGATGT GTATTAGCCC CGGAGGACGT GATGTGAGAC 3 00

CCGCTTGTGA GTCCTCCACA CTCGTTCCCC ATTGGCAAGA T AC ATGGAGA GCACCCTGAG 3 60

GACCTTTAAA AGGCAAAGCC GCAAGGCAGA AGGAGGCTGG GTCCCTGAAT CACCGACGCT 420

CGAG 424

(2) INFORMATION FOR SEQ ID NO: 3 50:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 44 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:350:

GAATTCGGCC TTCATGGCCT AATTAGATTA TTTTGAGCTT GGGAACACTT GTACATGGTT 6 0

CCCCGGGACA TAAATGTAGA AGTTCTGTAG AGCAGTATCT TCACATTGAG GGATGTGAAG 120

GCTTTGCAGA GTATAGATAG TTTAATGTAA TTTAGAGTTC TTCATTATCT TTCCTAGGAT 180

CAGATATCTG CCGATGATGA CTTCTAACCC ATTCAGAATC TTTCTATGGT ATATTGCCCT 240

GGGGTGTAAA ATCCTCCAGG ACCCTAAACA GATGGACAGT TGATGCATTT CAGGGTAAGC 3 00

TGTAGACAAC AATATATTTG ACCCCTGAAA CAATT CAGT A TGCTTGTCAT TTGTTAACTA 360

GAGTTATTTC AAACATAATT TTGAATAAAA AATAAATTTT AATAAATACA TGTT CC CAAT 4 20

TATGCATATA AAAGCAATCC TCGAG 44 5

(2) INFORMATION FOR SEQ ID NO: 3 51:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 278 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 351:

AATTCGGTTC ATGGCCTAAT TTTGGAACTA AGAGACAGAT TTTTTGTTTT TGTTTTTTTA 60

AATAGCTGTT AACTAGTCTC ATAAGGACAA AATACAGAAA GACAGTTCTT ACAGAGAAAT 120

AGAAGCAAAA AAAGGAACCA ATGGAAAATT TAAAACTGAA AAATAGAATA TCTGAAATAA 18 0

AAAATTCACT AGATGACATA ACTGTTGAGG AAAGAGTATG TGAATTTGAA GAAAGAGCAA 24 0

TAGAAATGTT CCATTGTAAA GAACAAAGAG AAC TCGAG 278

(2) INFORMATION FOR SEQ ID NO: 352:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 57 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

( D ) TOPOLOGY : 1 inear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 52:

GAATTCGCCT TCATGGCCTA CAGATTATCT TACACTGAAC TG AT CAAGTA CTTTGAAAAT 60
GACTTCGAAA TTTATCTTGG TGTCCTTCAT ACTTGCTGCA CTGAGTCTTT CAACCACCTT 120

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TTCTCTCCAA CCAGACCAGC AAAAGGTTCT ACTAGTTTCT TTTGATGGAT TCCGTTGGGA 18 0

TTACTTATAT AAAGTTCCAA CGCCCCATTT TCATTATATT ATGAAATATG GTGTTCACGT 240

GAAGCAAGTT ACTAATGTTT TTATTACAAA AACCTACCCT AACCATTATA CTTTGGTAAC 3 00

TGGCCTCTTT GCAGAGAATC ATGGGATTGT TGCAAATGAT ATGTTTGATC CTATTCGGAA 3 60

CAAATCTTTC TCCTTGGAX c ACATGAATAT TTATGATTCC AAGTTTTGGG AAGAAG CG AC 4 20

ACCAATATGG ATCACAAACC AGATGGCAGG ACTCGAG 457

(2) INFORMATION FOR SEQ ID NO: 3 53:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 295 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO:353:

GAATTCGGCC TTATGGCCTA GCAGGCGCCA AGGTAACATG AACAAACAGC TGCTTGCTGC 60

CCCCAAGCTT TAGTTTCTAG TGGGCCTGGA GCAATTGTGA AGGACAACTC CACCCAAGGC 12 0

CCAGTATTGA AGAGGGGTAG GGTGGGAGGA TTGTACATAT CGCGAACGCT TGG CAAATCT 18 0

CTAGATT TTT TTTCCTCCTA GGAAATAATA ATTTTTAAAA AGG CTTGTAA AAAATAATAA 24 0

AATGTTT CAT GACAGCAGCA GATGTAAAAC TCCCAGTACT CCGGGCGACC TCGAG 295

(2) INFORMATION FOR SEQ ID NO: 3 54:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 414 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 354:

GCCTAGACAT GATGGTGGCC ACGTGCCAGG GGACCACACC CTATGTACAA AG CAGG AG AA 60

TGATGCTCCC AGCTGAGCTG CAGGATGGGC GCTGGGCTGA CTGGAGGGGT AGACGGGGTG 12 0

GGGTCTGACC CCATTAGCCT TTCCCCATCC AACCTGGGCC CCCATAAGCC ATTCTCTGGC 180

CCTCTGCACA AG ACAG ACT C AGCAAATCTG CGAGGTATGG GGATTCTGCC AACTCCCCAC 240

CTCGCCTCAC CTTCCCTAGG TCTGCGCGTT AGGAGATTCT GGAGCCAGAG GGAGAGACCC 3 00

CAGAAACTCC CCGGTCGGCG ACCCAGCCCG AGACGCCTGG GGTCCCAAGG GAAGCTGAAC 360

GCCCGCAGAA TGGGGAAATG GAGAGAGAAC CTGAAAGAGC CCCTGTAACT CGAG 414

(2) INFORMATION FOR SEQ ID NO: 3 55:

(£) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 3 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 55:

GAATTCGGCC ATCATGGCCT ACTCCCGAGT AG CTGGGACT ACAGGCATGT GCCACCACGC 6 0

CCAGCTAATT TTTTGTATTT TTTTTAGTAG AGATGGGGTT CCACCATGTT AGCTAGGATG 120

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ATTTCGATTT CCTGACCTTG TGATCCGCCC GCCTCGGCCT CCCAAAATGC TGGGATTATA 1B0

GGTGTGAGCC ACCACGTGGC CTCATTTCAT TCTTTCATGT GGATAGGCAG TTGTTCCAGA 24 0

AGTATATAGT GAGGAGCTTC TTCTTTCTCT AATGATCTGC AATGTCACCT TCATCATTTA 3 00

TGAAGGTTGC ACATATACAT GGGAATTTTT TAGTCTGGCA TTAAATGTTC TTCAAAAGAG 3 60

TTCCTGCAAA CGTTTTTGTT TTTATTTCCT ACTGTTCCCT TCACGTACTC TCTACTGAAC 42 0

TAAACTCTCT AATGTGTCTC GAG 443

(2) INFORMATION FOR SEQ ID NO: 3 56:

(i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 286 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 356:

GCGATTGAAT TCTAGACCTG CCTCGAGCTC AAGAGCAGCC CACCTGTTCA GTATTCATAC 60

CCACATATCC ATAATAG AG C TCTTCTCTTC CCCCGGGTTC CTCTGCCTCA GCCTTTTCCT 120

CTTAGCAGAT GCCATCTGCA GGGCCACTTG GCTGCCCGTA GCAGTAACCG CACAGTCTTC 180

CACATTTACT CCCTCAGCCT CAGCTGCTCC TGCAGCCCAG GCACTGTCTC TGTCTCTGCA 24 0

TTGCTCAAGC CTCCACCATC TCGGTTACAC CCCACAGCCA CTCGAG 2 86

(2) INFORMATION FOR SEQ ID NO: 3 57:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 9 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 57:

GAATTCGGCC TTCATGGCCT ACTGCCTTAG CCTCCCAAAG TGCTGGGATT ACAGG CGTG A 6 0

GCCACCATGC CCAGCCCTAT AGTAGTTCTT CTTTTGCCCC TTAATATCCT CACCCACATG 120

TCCTGTACCC TGCCTGAACC CTCCTCCTCT TTTTGTTCTG ATCTTTGAGC TCCCTAGAGC 180

CCATAATTCT TTAGAGCAGG TATGTCCCGA GTCTGAAACA TGCCCTTATT TGTCCCAAGC 240

TCTGGACATT TCTCACCCCA TCT CTCGAG 26 9

(2) INFORMATION FOR SEQ ID NO: 358:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:358:

GAATTCGGCC TTCATGGCCT ACCAAGGAAG CCTTTCTGTT TTTGGCCCAA GGAGCGTCAA 6 0

TAAGATCTTT GAAAATACTT TGAAGTCATT TTGTGTGTGT GTATGTGCAT ACACACCTGA 12 0

TTTGTTTTAT TTTTTATTTT TATTTTTTGA GTTAGGGTCT GGCTCTGTCG TCCAGGCTAG 180

AGTGCAGTGG TGTGGTCTCA GCTCACTGCA ACCTCTGCCT CCCAGGCTCA AGCCGCCCCC 240

210

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CCACCTCGAG 250
(2) INFORMATION FOR SEQ ID NO:359:

(i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 258 base pairs

(B) TYPE: nucleic acid

<C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 3 59:

GAATTCGGCC TTCATGGCCT AATGGGAGAT TGGTGGGAGT AGGGAACACA AAAGGCATGG 60

GAAAAGAAGA TAGGTTGTAT TTTGGTCATA CTGACACCAA CATGCCTAAA GGATAGCCCT 120

GTGAAAAAAG CT AG CAGACA GTTGAACTGC GGCTGTGAAA CAGGAAGCCG TGAGGGCTAG 180

ACT CAT CGTT GTAGTCATTC GTAAAGAGTA AATACTTGGA GCTATTGTAG TAGATGGTAT 24 0

CACCACGGAA CACTCGAG 258

(2) INFORMATION FOR SEQ ID NO: 3 60:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 2 59 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 36 0:

GAATTCGGCC TTCATGGCCT AGGAAGCCAC AGGTCGGCTC TGCATTAGCA GGAGCAGCCG 60

CCCTCGCTGG CCGGGGGCTC CTGGGGTTTG TCCAGCTTGA TGTCGATCAT CCCTTCTTTG 120

CTTTTCTCCT GGACATTCTC CATTCCGGGT AGAGCCGACG CCACACGTCG AAAAAGCTGC 180

TTCACGTTGT AGCCAGTCTT CGCACTGGTC TCAATGAACA TGACGCTCAG TTCTTTGGCG 240

CGCTGCCCCC CCCCTCGAG 259

(2) INFORMATION FOR SEQ ID NO: 361:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 4 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 361:

GAATTCGGCC TTCATGGCCT AAAGATTAGC CTGGGTAACA TAGTGAGACC CTGTCTCTAT 60

TAAAAAATAA TAATAAAAAT AACATT CACA TTGGTATTGT TCACTAAGGT ATTGGTTGTT 120

AAGGCATTCA TTAAGGTATT GTTAAAACTT GTGTTAAGCA TGTTAAAGTC TCAGTAACTT 180

TGGGATAGAA ATAAAATGTG ATAAAAAG CT GAAAGAAACC ACCACAAGGG AGAGTCCTTT 240

TTGAAATATT AGAGACATAA TGCTGTCTAA TAAAAAACGA CATCAAAGAA AAACTACACT 3 00

ACAGTGACTG CAGACTTAAT GTTGGCCAAC CATGCATCCT CCC TAGAAAT G CATTTGAAT 360

TTGATTTACT AATCTTTTAT TTAGGAAATT TACATTTTTA CATTAGTGAG ATTGGCCTCG 4 20

AG 422

211

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(2) INFORMATION FOR SEQ ID NO: 3 62:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 2 88 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 3 62:

GAATTCGGCC TTCATGGCCT AGTTATTCTT CTAATAGCTC AGCTACTTTT CCTTAAAATA 60

TCTTTTTCTC TGCAAAGCCT TCATATAATT GTTGTTATTA TAACAGTGAT GATGACTGCC 12 0

ACTCATTACA ACTGCTGTTG TTAATCTTTG TTGTTATTTT AAAC CATATG TTATTTAAAC 18 0

CATAAACTGC ATCATAAAAG CAGTTTCTTT CTAATCCATG ATGACAC CTG CTAGCCAGGT 24 0

ATCGTAT CAA TTCTTCACAG GTCTATTGAA TTCTAGACCT GCCTCGAG 28 8

(2) INFORMATION FOR SEQ ID NO:363:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:363:

AAAAATTTCA ACAAATCCTG AAGTCTTTCT GTGAAGTGAC CAGTTCTGAA CTTTGAAGAT 60

AAATAATTGC TGTAAATTCC TTTTGATTTT CTTTTTCCAG GTTCATGGTC CTTGGTAATT 120

TCATTCATGG AAAAAAATCT TATTATAATA ACAACAAAGA TTTGTATATT TTTGACTTTA 180

TATTTCCTGA GCTCTCCTGA CTTTGTGAAA AAGGGTGATG AAAATGCATT CCGAATCTGT 24 0

GAGGGCCCAA AACAGAGACT CGAG 264

(2) INFORMATION FOR SEQ ID NO:364:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 260 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:364:

GAATTCGGCC TTCATGGCCT AGACCCTCAT CAATAGATGG AGACATACAG AAATAGTCAA 60

ACCACATCTA CAAAATG CCA GTATCAGGCG GCGGCTTCGA AGCCAAAGTG ATGTTTGGAT 120

GTAAAGTGAA AT AT TAGTTG GCGGATGAAG CAGATAGTGA GGAAAGTTGA GCCAATAATG 180

ACGTGAAGTC CGTGGAAGCC TGTGGCTACA AAAAATGTTG AGCCGTAGAT GCCGTCGGAA 240

ATGGTGAAGG GAGACTCGAG 260

(2) INFORMATION FOR SEQ ID NO: 3 65:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 32 base pairs

(B) TYPE: nucleic acid

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(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 365:

GCGCCTATCA CAAGCAGATC ATGGGTGGCT TCAAGGAGAC GAAGGAGGCT GAAGATGGCT 60

TCCGCAAGGC CCAGAAGCCT TGGGCCAAGA AGATGAAGGA GCTGGAGGCA GCCAAGAAGG 12 0

CCTACCATTT GGCTTGCAAA GAGGAAAAGC TGGCCATGAC ACGGGAGATG AACAGCAAGA 18 0

CGGAGCAATC GGTCACACCT GAG C AGC AAA AGAAGCTGCA GGACAAAGTG GACAAGTGCA 24 0

AGCAGGATGT GCAGAAGACA CAGGAGAAGT ATGAGAAAGT GCTGGAAGAT GTGGGCAAGA 300

CCACACCCCA GTACATGGAG AACAAACTCG AG 33 2

(2) INFORMATION FOR SEQ ID NO:366:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 30 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 366:

GAATTAACAG AGTTTTCAGA ATTAGAATAC TCAGAAATGG GATCATCGTT CAGTGTCTCT 60

CCAAAAGCAG AATCTGCCGT AATAGTAGCA AATCCTAGGG AAGAAATAAT CGTGAAAAAT 120

AAAGATGAAG AAGAGAAGTT AGTTAGTAAT AACATCCTTC ATAATCAACA AGAGTTACCT 180

ACAGCTCTTA CTAAATTGGT TAAAGAGGTT GAAGTTGTGT CTTCAGAAAA AG CAAAAGAC 24 0

AGTTTTAATG AAAAGAGAGT TGCAGTGGAA GCTCCTATGA GGGAGGAATA TGCAGACTTC 300

AAACCATTTG AGCGAGTATG GGAT CTCGAG 33 0

(2) INFORMATION FOR SEQ ID NO: 3 67:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 67:

GCGATTGAAT TCTAGACCTG CCTCGAGTAC GGAGCGAAAC TCTGTCTCAA AAAAAAAAAA 6 0

AAAAAAAAAA ACCGAGTATA AAAGGCATTT TTTTCCTTTA AACTAAGTAA AATATAATGT 120

TGAATAGTTC TATTTTGCTT AACGGG CTTT TGTTATTTGT TTTGTGTAGA AATTGGCATT 180

TTTCACATAG AAAT CTCGAG 200

(2) INFORMATION FOR SEQ ID NO: 368:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 368 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

213

PCT/US98/06956

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 3 68:

GAATTCGGCC TTCATGGCCT AGAGAAATGA GGAAAAAGAA GGAAGAATAT TTAACTTTTA

GTCCTCTTAC AGTTGTAATA TTTGTGGTCA TCTGCTGTGT TATGATGGTC TTACTTTATT

TCTTCTACAA ATGGTTGGTT TATGTTATGA TAGCAATTTT CTG CAT AG CA TCAGCAATGA

GTCTGTACAA CTGTCTTGCT GCACTAATTC ATAAGATACC ATATGGACAA TGCACGATTG

CATGTCGTGG CAAAAACATG GAAGTGAGAC TTATTTTTCT CTCTGGACTG TGCATAGCAG

TAGCTGTTGT TTGGGCTGTG TTTCGAAATG AAGACAGGTG GGCTTGGATT TTACAGGATA
TTCTCGAG

(2) INFORMATION FOR SEQ ID NO: 369:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 299 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 369:

GAATTCGGCC TTCATGGCCT ACATT CGGAG AAGTTGAAAG AATTACACCC AGAACAC CCA

TGTCTACCAT GTTACTACAT TTGTGTGTGT GTGTGTGTGT GTGTGTGTGT GCGTGTGCAA

TTTTAATTAC AATGGTCGAG GAAGCTCTTG CTGAGAAGGT GATGTTGAAT AAAGACTCTA

AAGACCCTAA AGAGTTGAGA GAGAGCTGTG TGGAGTTCTG GGGCCCAGGC ACAGCAAGTA

CAAAGATCCT GAAGCAGGAG CATTCTTGGT GTGTTCAAGG AAAG CAGG AC AACCTCGAG

(2) INFORMATION FOR SEQ ID NO:370:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 28 9 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 370:

GAATTCGGCC TTCATGGCCT ACCGCCTTTC CATTATGCAA
TTATACGACG ATTATTTGTC AACCCCACTA TCTTTGCACT
TCAGAGACCT CGTGACAGTC ATCTTCTCAT CACCACATCT
GG C AGCAACA GTCCACCTCC TCCAAGAAGC AGTCCCTGAT
TTCGTCTCTC TGTTCTTGGA AACTCAAAGA ACTAAGCACC

(2) INFORMATION FOR SEQ ID NO: 3 71:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA
(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 371:

CTGTGGTGGC TTTTCTTTTG
CAACCATGGG CCCCCTGGGC
GCAAATGTGT GGGTGGATGG
TTTTCCTCCC C AGACAAAT C
TCCCTCGAG

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AATTCGGCCT TCATGGCCTA CAAGCTCGAT CATTATCCTT
AGTTCATCCG ACACCCTCTT CAATTCTCCC AAGTCGCTCT
ACAGGGAAAA TTGACCAAGA GATTCACAAA TACAACACCC
TCCAGAGTCC AGTTCAACCA GATCGCCCCT CTCAAGGCCG
TCGGCTCACG TCCACATCCA GGGCGAGCTG GTGGAGTCCA
ACCCTCTCCC CCATGTCGTC CGCCACCGAC CCCTGGCACC
AGTGCGGATT TTCCATATAA TCCAGGACAA GGCCAAGCTA
AACTCGG CTA TCATTGGAGG CGTCATTGCT GTGGTGATTT
GTCTTCCTGA TCCGGTACAT GTTCCGCCAC AAGGGCACCT

CTGTGAGTTA CCATCTGCCA
TT CTGGG AAA AG TTATAG AA
CAGGATTCAC TGGTTGCCTC
CCTTGAGGCA GACAAACGCC
ACTGCGGGGC CTCGCCGCTG
TGGATCACCT GGATTCAGCC
TAAGAAATGG AGTCAACAGA
TCACCATCCT GTGCACCCTG
ACCATACCAA CGTTCTCGAG

60
120
180
240
300
360
420
480
540

(2) INFORMATION FOR SEQ ID NO: 3 72:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 52 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 72:

TCGACCCCTG GCTAATGACA AACTATGTGA CCTTCATGGT GGGGGAGATT CTGCTCCTCA 60

TCCTGACCAT CTGCTCCCTG GCTGCCATCT TTCCCCGGGC CTTTCCTAAG AAGCTTGTGG 120

CCTTCTCAAC TTGGATTGAC CGGACCCGCT GGG CCAGGAA CACCTGGGCC ' ATGCTCGCCA 18 0

TCTTCATCCT GGTGATGGCA AATGTCGTGG ACATGCT CAG CTGTCTCCAG TACTACACGG 24 0

GACCCAGCAA TGCAACGGCA GGGATGGAAA CGGAGGGCAG CTGCCTGGAG AACCCCAAGT 30 0

ATTACAACTA TGTGGCCGTG CTGTCCCTCA TCGCCACCAT CATGCTGGTG CAGGTCAGCC 36 0

ACATGGTGAA GCTCACGCTC ATGCTGCTCG TCGCAGGCGC CGTGGCCACC ATCAACCTCT 420

ATGCCTGGCG TCCCGTCTTT GATGAATACG ACCACAAGCG TTTTCGGGAG CACGACTTAC 4 80

CTATGGTGGC CTTAGAGCAG ATG CAAGGAT TCAACCCAGG GCTCGAG 527

(2) INFORMATION FOR SEQ ID NO:373:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 407 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 373:

GG CAAGAAAG
TGGAGAAGCT
AGGAAGAGCG
TCTCAGGCAA
AGGAAAAGAA
CAGAAATGGA
TTCGTGCCAA

GATGTCCGCA CAGCTGGCTG
TCAGCTACAA GCCCTTGAGC
TGG CAAGAAC AAGCAGGTGG
AGT CAT AGAG GAGGCCCAGA
AAAGACGAAT GAATTAGAAG
AG CTCAGATG GAAAAACAAC
GCTGAACCGG GAAGAAGCAC

CTGCTGAGAG CAGACAAAAG AAG CTGGAAA
AAGAG CACAA GAAGCTGGCT GCCCGCCTTG
TCCTGATGCT GGTCAAAGAG TGCAAGCAGC
AGCTCGAAGA CGTAATGGCC AAACTGGAAG
AGGAACTCTC CGCTGAGAAA CGAAGAAGCA
TCTCTGAGTT TGACACTGAG CGGGAACAGC
ACACCACAAA CCTCGAG

60
120
180
240
300
360
407

(2) INFORMATION FOR SEQ ID NO:374:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 322 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY; linear

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 74:

GAATTCGGCC TTCATGGCCT ACTCTGTTTT CTCCCTGGAC TTATGTGCTT CGTCTGGAAT 6 0

GTTACATCTC TTCCTCTCTT TCTTTTTTTT TGGTCCCCAT GTTGACTGTT TTATTGGGGT 12 0

TTCTGGATAT CTCGGGGCCA CCTCACAGGA AGCGGTTTGC AATGAGATCA T AAACATTG C 180

CGAAAAATCT GTTCATTACT GCAGCACTGT TTCTCATCCC CTTGACTTTC ATCACAAGGT 240

ATCCCCTTCT GACAATAAAT CATCTTTAAT CATTTCTCAG CAACCTCAAG CCCAGCAGCG 3 00

AAGAGTCACC CCCTATCTCG AG 3 22

(2) INFORMATION FOR SEQ ID NO: 3 75:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 480 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 75:

GAATTCGGCC AAAGAGGCCT ACCTAAACCG TCGATTGAAT TCTAGACCTG CCCCAAAACC 60

AACAAGGAGA ACAAGCTCAG TCTTCTGTGT CTTAATTTTT GGCTTTACTC TTAGCCCTGC 120

CCCATTTCCT AGGCTCTCCA CAGTCCAGCC GCTTTGAGCT ACTTTTCCTT CCCTGATATG 180

TGCAGCTCTC TCACCTCTGA GCCTCCGCAC CTGCTGTTCC ACAGCACTCT CCGCATTGCC 240

TTCTCCCACT GTGGCTCACT GCTGAGCTGT GTTCAGGCCC TTTGGGAAAC CCTCTCTTTC 3 00

ACTCCTTTTC CCTGGTCTGG CTTGGGAGCC CATGCTTACC CCTGTCAGGA CACCTTGAAA 3 60

CCCAGCAGTG AAAACATGAC ACTTCCTTGT CTGGCTGATT TTCTTAGTGA AGCGAGTAGG 4 20

AGTTTCCTTT GTCAGGACTT CAGCAAGCAA AATTCAGGAG AGGTCATAAA ATGTCTCGAG 4 80

(2) INFORMATION FOR SEQ ID NO: 3 76:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 83 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:376:

GAATTCTAGA CCTGCCTCGA GTAACCAGAG AGTCTTGTCA ACATTAACAC TAGCAG TATT 60

TCCAACACTT TATTTTTTTA ACTTCCTTTA TTATACAGAA GCAGGATCTA TGTTTTTTAC 120

TCTTTTTGCG TATTTGATGT GTCTTTATGG AAATCATAAA ACTTCAGCCT TCCTTGGATT 180

TTGTGGCTTC ATGTTTCGGC AAACAAATAT CATCTGGGCT GTCTTCTGTG CAGGAAATGT 24 0

CATTGCACAA AAGTTAACGG AGGCTTGGGA AACTGAGCTC GAG 2 83

(2) INFORMATION FOR SEQ ID NO: 3 77;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 377:

GAATTCGGCC TTCATGGCCT AAACAGCAAA GAACAACTCA TCACCGCTCA CGTTCAGTAT 60

CTCCTCATCG CGGCAATGAT C AG GGAAAG C CGCGTTCACG TTTACCAAAT GTG CCATTAC 120

AGAGGAGTTT AGATGAAATT CAT C CAACAA GAAGGTCACG TTCTCCAACC AGACACCATG 180

ATGCCTCCCG AAGTCCAGTT GATCATAGAA CCAGAGATGT GGATAGTCAG TATTT AT CAG 24 0

AACAAGACAG TGAGCTTCTT ATGCTGCCCA GAGCAAAACG AGGACGAAGT GCAGAATGCC 3 00

TACATACTAC CAGAATGTCT CGAG 3 24

(2) INFORMATION FOR SEQ ID NO: 378:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 52 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 378:

GAATTCGGCC TTCATGGCCT ACTGAAATTT CAATAAAACC AGCTTGAAAG TTCCATTACT 60

AGAAAGATAA GAGTGGTCAG AAAACATTTT TTATTAACCT ATTTCATCTA GTAAGAG TAT 120

CTTAAATGTT TTTTCTCTTG AGTACTGAAT ACACATGCAG GACAATGGAC CTAAATACAG 18 0

TTAACTTTTG TTTTTCACTC CTTTGCTTTT GCATTGTCAA TAGTCCGGTA AGGTTTAGGT 24 0

TCTAT CAGAA GTACTCAGAC ATGCAGTGGG CAATCGATAA TTTCTACCTG GGCCCTGGAT 3 00

GCTTGGACAA CTGCAGGGGC CATGGAGATT GCTTAAGGGA ACAGTACTCG AG 3 52

(2) INFORMATION FOR SEQ ID NO: 3 79:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 271 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 379:

GAATTCGGCC TTCATGGCCT AGTCTGTGTG TAGTGGAAAC TCTATTGCCT GCCCTGCACA 6 0

TCTGCTCCTT TTCTTCTCTG CACTCTGGGA CAGCTTCTAA AGTTTGTCCA ACATGTCATT 120

GACTGAGTTT TGTATCATTT CAGTTCTGCT CTTTACTGGT TCCTATGTGG ATGCTAATTA 18 0

TGCAAATGCA TTTTCCACCT CTTGCACTCC TTTTTCTAAG TCACCTCACT TCTCATTTCC 24 0

TCATGTTTTT CCNTTATCCT CTTCTCTCGA G 271

(2) INFORMATION FOR SEQ ID NO: 3 80:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 71 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 80:

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GAATTCGGCC TTCATGGCCT AACGCGGCCA GGCGATTCGG TGAAGCGATT CCTGCAGGCG 6 0

TTGGTTCCCC TCTTTGACCT GGTACAAAGA ATTTTACGTG AAAGATTTTG TCGTCAGAGT 120

CCAGATAGTA ACCTATTTGG AGTGCAAGTA CAATACAAAC ACTTAAGTGA G CTG CTG AAA 180

AGAACTGCTC TCCATGGAGA GAGTAACTCT GTCCTTATTA TCGGACCCCG AGGATCAGGA 24 0

AAAACTATGT TAATAAATCA TGCTTTGAAA GAACTCATGG AAATAGAAGA AGTGAGTGAA 3 00

AATGTATTAC AAGTTCACTT AAATGGACTG CTGCAGATCA ATGACAAAAT CGCCCTAAAG 360

GAAGTCTCGA G 3 71

(2) INFORMATION FOR SEQ ID NO: 3 81:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 277 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi> SEQUENCE DESCRIPTION: SEQ ID NO:381:

GCAGAGTTAA GCAAATTAAT TATAGCTATC TTTAAGCTAT AAATG TGTTA ACATGTATAT 6 0

ATACCATTTA TTATGTTCTA CTTTAGTGAT ATAC CTTAAT TTAGTGGGCT TTGGCAGGGC 12 0

GGGGGAGGGG GAACGTTCAT TAATCTCTGA GGAAAACAAA ACCTGTTTTC TACTTGAGTC 180

TAACATATGG TCCCAATTTA TTAATACTTC TGTTAAATTT GATGTCAGGT CAACATTTTT 24 0

CAGAAATGTA TTTATTCTCA GAAACAGAAC ACTCGAG 277

(2) INFORMATION FOR SEQ ID NO: 382:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 290 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 82:

GAATTCGGCC TTCATGGCCT AGTTGTTACT GGAGTTAAAG AGAGAACTGA GAAAGACAAA 6 0

GGAGTAGAAC GTTTACTCAA ATAAGTAATA ACAGAAAACT TTCCAAACCA GAATATACAG 12 0

GTACAGGAAG GTCAAGGGTC ACCAATCCGA GTTAACTCAG ACAAGAATAC TCCAATTTAC 18 0

AAACTCATAA GGGTCAAAGA CAAAGAGAGA ATTTAGAAAA CAGCAGGAGA ATAGAAGCAA 24 0

ATAACATATA AG ATAGAT C C AATATG CTTG G TAG CAGATT TCTCAGCAGG 290

(2) INFORMATION FOR SEQ ID NO:383:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 241 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:383:

GAGAGTGTGG AGAGGGTACA TTTCCCTTGT ATNCTATGTT CTTCTTTCTA GTGGGTCTCA 6 0

TGTAGAGATA GAGATATTTT TTTGTTTTAG AGATTCCAAA GTATATATTT TTAGTGTAAG 12 0

AAATGTACCC TCTCCACACT CCATGATGTA AATAGAAC C A GGAATAAATG TGTCNTTGTG 18 0

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AT AATC C CAT AG C AATTT AT GGTAAGAACA AGACCCCTTT CCCTCACCAC CGAGTCTCGA 24 0

G 241

(2) INFORMATION FOR SEQ ID NO:384:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 299 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:384:

GAATTCGGCC TTCATGGCCT AGAAACACAA TAAAGCCCCA CAACAG C AAA CTTTTTAAAC
GACGAAAGAG AG CTCTAAAT AACAGCAAAA TGCTGCTCTT CTTGCTCCCA TTATGTTTAC
TATTACTGTG CTCTAGTGAG AATAG CAAGG GGTCAAAGGA ATTTATAACA CTTCCTATAC
CTTCAACTTA CCAAGTCCCC TACCAAGTAA CAGTTTTCTG TCAGAGAGAA AGTTCTGCCC
TCCCTGCTCA AAGGTGTCCA TGCCAACTAG ACTTCCCCTG TAG CTACCTG GGTCTCGAG

(2) INFORMATION FOR SEQ ID NO: 3 85:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 6 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 85:

GAATTCGGCC TTCATGGCCT AG AAAGAG GT GGCAGAAGGA ATGGTAGGAA GGGGAGGATG

TAAGCGATAT CATCAAGTCA GAATCATGAG TTCTTGGTGC CCGGATGTTA GAGGAGGGAA

AAGGTGAAGA TGGCTGAAGC TGTACACTTT CATGATGGTG GAATGGAGGG GTCCCTTGGG

AATTAGGGGT GTCTCTAGGA AGAAC CAGCT TAGGGTACAT TGAGAAAGAG GAGACAGGCT

AGGCAGGTCT AGAATT CAAT CGCAGATCAC AG CTACAAGG ACCAGGCCTT TGATACTCTG

AGCCTCGATA GCTCTGATAG CATGGAGACC AGCATCTCTG CTTGCTCACC AGACAACATC

TCTAGTG CCA GCACTTCAAA TATTGCTAGA ATAGAAGAAA TGGAGAGACT TTTGAAGCAG

GCTCATGCAG AAAAGACGCG GCTGCTCGAA TCCAGGGAAC GGGAAATGGA AGCCAAAAAA

CGAGCCCTGG AAGAAGAAAA ACGACGCCGG GAAATCCTGG AAAAACGATT ACAGGGATAG
CTCGAG

(2) INFORMATION FOR SEQ ID NO: 3 86:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 317 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 86:

GTTAGGATCA TACATCATAG GTGTATGTTT AACTGTTCAA GAAACTGCCA AACTGTTTCC 60

CAAAGTGGTT GTATTGTTTT ACATTTCCAC GAGCAGTGTT TGAGAGCTCC AGTTCTTGCA 120

CATCCTAGCC ACAAAAAGGT TCTGTTTTTT AAAGACAATT TTTTTTTTCT TTGAGAGTTT ISO

219

60
120
180
24 0
299

60
120
180
24 0
300
360
420
480
540
546

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CGCCCTAGTC GCCCAGGCTG GAGTGCAGTG GTAAGCGAAT CCCTGCTACA GGCCAGAGAC 24 0

TGTTCTCAGT TGGTTTTTAC ACCAAGTATC GCACTTCATT CTAACACTCC ACCATTTTAC 300
AAATGAGATT TCTCGAG 317

(2) INFORMATION FOR SEQ ID NO: 387:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH; 234 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 387:

GAATTCGGCC TTCA T GGCCT AGGTCAGGTT AGTCAGCTAA TGGATAAGAG ACTTGAAATT 60

ACTCTTTTGG GATTAGCAAA TAGAAGGGAA AAACATGATA AGGGCACAGA GCGGTGGGTC 12 0

TGGGGGAAAA AGCAGAGGCA CAGTTTGAAA AAAATGTGTA AGAGACTGAC TAGGTAAGAT 180

ATGGTCACAG TTCATAAGTC CTTTGAATTC TAGGATTAAA AAGGTGAACT CGAG 234

(2) INFORMATION FOR SEQ ID NO:388:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 294 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 88:

GAATTCGGCC TTCATGGCCT ACTAGATAAG TGTCAATTCC ATCTG CTTCT GATTTCCCAC 60

GTCACTGCCC TGGTCCACAC ACTGTG AT CT TCTGCCCCCA TCTGAGTGCC GCATACTCAG 12 0

CCTTGTCCCT GCATCAGACC CCGGCCCAGC ACAGTAACGA GAATGGGCTT CCTAAACACA 180

AAT CTGATTT GTTCCGCCTT CCACTTCCTA GTGGCTTCAT TCTCGTGCCC TCACTCAGGG 24 0

CCCTCACACA TGCTGTTCCC TGCACCTCCG ACACCCTTCC CAGCGCCCCT CGAG 2 94

(2) INFORMATION FOR SEQ ID NO: 3 89:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 215 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 389:

GAATTCGGCC TTCATGGCCT AAGCAAAGCT AAGTGTAAAA CTAAAAAGCA GTTTGTTGCA 60

ACTGGTCATA AAAGTGATTA AATCTAAAGC TGGCATTAAT AAGGAAGCAA GGTAATAAAA 120

CAAAAATATA AACAGCTTTG AGAAAGTACA CCTAATAACA AAATCTTGTA ACACAACAAA 180

TGAAAATCAC AAAAAATATA AGGAGACTCC TCGAG 215

(2) INFORMATION FOR SEQ ID NO: 390:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 477 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

( D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 90:

GAATTCGGCC TTCATGGCCT AGAAAAACAC TATAGTCACG CAAGTAATGA CCCTTCTTAT 6 0

CCTCAACCCC CAGCATATAT GCACAAGGAC AAACAGTATA CAT ACAAT CT CACCTGAGAG 120

ACGTCCTCAG ACTTGTGTTG AAACCTTATC ATGCTGCATT ATCTCCCTTA CAACATCCTT 180

CCTGCCTTGT TTCTCATTTT CACACTATAC GG AG TAAAAA AATATACAAT TTCTATATAT 240

TATATATATA ACCTCCATAT ATTTTATACT ATTTCATATT TTTATACTAT CAGATTAATG 300

TTTTATATTT TATCTATCAT TTTAAATATG CTATGTAAAG CATCTACAAA ATTGGTCACC 3 60

ATTCCTATGG GAAGTATCTG CAGAACTCTA GAAATGAATT CATCTTTTGC TTACCCCTCC 4 20

CTTTTTGAGG GGACAGGGAC TTTCTTCTTT TCCCTCATCT TCATCTTCCC CCTCGAG 477

(2) INFORMATION FOR SEQ ID NO: 3 91:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 91:

GAATTCGGCC TTCATGGCCT AGTTAG TCAG AGTGAAATAT TCAATAATGA GTGGTGCAGC 6 0

CTTGGGACTT GAGATTGTTT TTGTCTTTTT TCTGGCATTA TTTCTGCTTC ATCGATATGG 12 0

AGACTTTAAG AAACAG CAT A GACTTGTGAT TATTGGAACA CTGCTTGCTT GGTATCTCTG 180

CTTTCTTATT GTCTTCATAC TGCCTCTGGA TGTTAGTACG ACAATATACA ACCGGTGCAA 240

GCTCGAG 24 7

(2) INFORMATION FOR SEQ ID NO:392:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 366 base pairs

(B) TYPE: nucleic acid "

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 92:

GAATTCGGCC AAAGAGGCCT AGTCATCTGC ATTTATTATG AGCAGCAGGT GGGACACTTC 6 0

CAGCAACAGT AAAAAAAAGT AATTTACAAA AGCAGGTTTC AGTGAAGCCA TCTGGTTGTT 120

ACCCTTGGGT GCTCACACGT AGATGCCAAC CCAGAGCAGC AGGAAGAGGA CTCCAAAGCC 180

CATGAAGAGT GAGGCCACTA AGGAGATGAG GAGCTCTTTA TAGATAT CAC GAGTGTACTT 24 0

GGTAGAGGTG ACCTCGTAAA CGAAGAACCA GGCGGTGAAG AACATGC CAA TGGCCAAAAG 300

CACCACGGTC AGATGGGGGA AGACAGCTGG GTTCACTGGG CTGGTATATC TGCTCATGGC 360

CTCGAG 366

(2) INFORMATION FOR SEQ ID NO: 3 93:

(i) SEQUENCE CHARACTERISTICS:

221

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(A) LENGTH: 2 05 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 393:

GAATTCGGCC AAAGAGGCCT ACCCTGGGTT AACATTCAAG ATGGTACATG CTGAAGCCTT 60

TTCTCGTCCT TTGAGTCGGA ATGAAGTTGT TGGTTTAATT TTCCGTTTGA CAATATTTGG 120

TGCAGTGACA TACTTTACTA TCAAATGGAT GGTAGATGCA ATTGATCCAA CCAGAAAGCA 180

AAAAGTAGAA GCTCAAAAAC TCGAG 2 05

(2) INFORMATION FOR SEQ ID NO:394:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 87 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 94:

GAATTCTAGA CCTGCCTCGA GCCGGAGATG GANAAGAAAG TCAGCCTACT CAAGGACAAT 60

AGCTCTCTGG AATTTGACTC TGAGATGGTG GAGATGGCTC AGAAGTTGGG AGCTGCTCTC 120

CAGGTTGGGG AGGCACTGGT CTGGACCAAA CCAGTTAAAG ATCCCAAATC AAAG CACCAG 180

ACCACTTCAA CCAGCAAACC TGCCAGTTTC CAGCAGCCTC TGGGCTCTAA TCAAGCTCTA 24 0

GGACAGGCAA TGTCTTCAGC AGCTGCATAC AGGACGCTCC CCT CAGGTG C TGGAGGAACA 300

TCCCAGTTCA CAAAGCCCCC ATCTCTTCCT CTGGAG CCAG AGCCTGCGGT GGAATCAAGT 360

CCAACTGAAA CATCAGAACT TCTCGAG 3 87

(2) INFORMATION FOR SEQ ID NO: 3 95:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 553 base pairs

( B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 3 95:

GAATTCGGCC AAAGAGGCCT AT CG AG AAGC CTTGTTTATT TAATGTGAGT TTGTGCCTTT 60

TTGTCTCAAT CTTCCAATAC AGGTATATTG AGAAAAAAAG CAGTCTAATA AAATC CTAGA 120
CAGAACTTTC TGGAGTCCAG TTTGGTGATG TCCATTTTCC AG CTGTATGT ATCCTCAAAC ■ 18 0

TTGCACTGAT AACCGCCATT TTACCAGGGC AGGATTAGGA AGAGGTACAA AGGTGTGTCT 24 0

GAAAATTTTT GCACGTGGAT TTCTGCATAT AATAGTCCCG TGTCAGTTTA CTTATGCAAA 30 0

CATTG CACAT CTGAATTGTA ATTCGGCCGT TTCCTACTGA CAGGATGTCC TTTTGCTTTT 36 0

GTCTGCCTCC TCTTCACATC TTCCTCTTTA TCCACCCTGC AGCCGGGGGG CGGGGGAGAC 42 0

CGGATCCCAG GCAGGACAGT GGCTAGGCTG CGTGTCCCCA CCCCCGACCC TCGTTTGACC 4 80

CCTGGGAGCC GGGGCGAAGA CAGCACAAGG ACGGAGCCCT CGGATCCCTC ACGAGTGGGG 54 0

CAGAGGCTGC GGG 553

(2) INFORMATION FOR SEQ ID NO: 3 96:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 72 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 96:

GAATTCGGCC AAAGAGGCCT ACAAGGTTAC TTGAC CAAGA TGGTGACATT GTAAGATTTG 6 0

AACAAAGGAA ATGTGACTTC AG AG TCATGG TTGTTAACTA TGCTATGAAG TAGGAAAACT 12 0

TTATGAGGTC TTTTTAACTC AAACAGT CG A GTTTTAAGTT GAGGGTTAGC AATGATGAAT 18 0

GAGTGGCCAA AAAATGTATT CATATTTTTA GTCTTTCTTA GAATTACTGG TAGTTGTGCA 24 0

CAACTAGAGG GTATTTATTT GTGTGTGTAT GTGTCGTGTG TGTACGAGTG CTGGAAATAC 3 00

TCTGCCAGTT TACAGTAGAG GCAGGCTTAC ATAATT CAGT CATGAAAGCT GAGGCTTATA 3 60

GTTTAGAGGG GATCGTCCTC TTCTTAATGA GTCTGTAAGT TACAAAAATA ACTTTTTTCT 42 0

TTATTTACTA ACTGGTTGGT TTTTAATATT AAAATATTAG GTGCTTCTCG AG 472

(2) INFORMATION FOR SEQ ID NO: 397;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 97:

GAATTCGGCC AAAGAGGCCT AGATTGGGGG ACATTCTTCT TTAGAAGGAA AAGAGTCTAA 6 0

TTAGTGGATA TTAAGTAATT AAATAATACA TACTATCAAA TATTATGAGA GTCACATGAA 120

CCATGAAGTC TTCACTTAAT TTAGGAGAAA TGGGGAATAT TTTCTATCAT TCCTGATAAC 18 0

AGAACTAGAT ATTTCAAGAT CATAGTCATG GAATGTAATC CATAATACCA AACAGGGTGC 240

TTTACTTTGA AGCCATTGAC CATTAAATTT GATTGTTAGT AG CACAGG CT ACCAAAAAAT 30 0

AGCAAGGAAT ATGGTATCCA CACAGATCTC GGCTGGCCTC AAGTAATCAA AAGTGAGAAT 360

GAAACATACA TGACACAACT GGGGACCTCT GGGTTTCTGA GACGTGGGCT ACAAGATTAT 420

ATTAGGTAGA AAACTAAAGG AAATGTATTC CAAGCAAAAG TGGCAAGGGA ATTTCACAGA 480

ACTAATTTTT TAAGGGAGGT AATAAAAGCA G CAGT TAAAA TGCATGTCCA TGTATCAGAT 54 0

TCCTGGAG 54 8

(2) INFORMATION FOR SEQ ID NO:398:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 462 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:398:

GAATTCGGCC AAAGAGGCCT AGGCTAAATA . CCGGCACGAG ACCGATTTTC TGAAGACAGC 6 0

AG AT TTATCA CTGTTAATCC AG CGG AAAAA AACACCTCTG GAATGATAAG CCGCCCTGCT 120

CCAGGGAGGA TGGAGTGGAT CATCCCTCTG ATTGTGGTAT CAGCCTTGAC CTTCGTGTGC 180

CTCATCCACT TCTCAAACTC GGAGAACTGC AAGGAGCTGC AGCTGGAGAA GCACAAGGGC 240

GAGATCCTGG GCGTGGTGGT GGTGGAGTCG GGCTGGGGCT CCATCCTGCC CACGGTGATC 300

223

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CTGGCCAACA TGATGAATGG CGGCCCGGCT GCCCGCTCGG GGAAGCTGAG CATCGGGGAC 36 0

CAGATCATGT CCATCAATGG CACCAGCCTG GTGGGGCTGC CCCTCGCCAC CTGCCAAGGC 42 0

ATCATCAAGG GCCTGAAGAA CCAGACACAG GTAAAGCTCG AG 4 62

(2) INFORMATION FOR SEQ ID NO; 3 99:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 428 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3 99:

GAATTCGGCC AAAGAGGCCT AGGCCGGGCA CACAGAAAAA TGCGAGGAAT AGAAATGCTT

GCATACTCTT GATTTTTTTT TTTTTTTTTG GTGTAAAAAA CACACCCTCC CCTCCCACCC

CAAAAAACAT CAAATTCCTT CCTTTTCCCC AAATCCCTGG ATCTTGGAAT GAAAGCCACC

CTTCCCCAAT CTGTCCTCAC CTCCTTCAGC C CATC CAAGT TATGCACAAA AAAACAAAAA

TTAGTGAGAA ATTTGGGGAT TTG CACAACA AAAAATTAGA TAATGTTTTC CAAAACTAGG

TCTTCTATGC TGTGTCAAAA AAAGTTTCCT ACAGACTGAG GATATTCACA CG ACAGGAG C

CTGGGGGTTA AATGAGCCTT TATTAGAATG TTGTAGCAGT TGTGTTTGAA GGCGGTGGCC
CTACAAAA

(2) INFORMATION FOR SEQ ID NO: 4 00:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 00:

GAATTCGGCC TTCATGGCCT AAGTTGAAAC TTACGAGTAA CATACCTGGT GTCTGATTGG
TTGTCATACT TTTCATTTTC CCTCCTTTCA GATCCAATCC ATTCTACACA TTATACTGAT
TTTTTCCTAG TGTACTGATT TCTGTTATGT CACTTTGCTG CTTAGGCTTC TTAATGCTTA
CTGTATCAGG TGTAAACACC TTTTGCTTAC CTTTCCAGGC CTTTTTAGAG TCTTATATAG
CTTACTCCCA TGCTCCAACT CCCCTCGAG

(2) INFORMATION FOR SEQ ID NO: 401:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 01:

GAATTCGGCC TTCATGGCCT AGGCACTTTG AAGAGATATA GAACTCCGTG TAT CACATTT 60

TCCATTTTTA TTTCAATTTT TAATTGCCCA GAGCCTAATT TCTGTGGGCC TCTGCTGATT 120

TGCACATTTG AGATTCGTGT GTAAATATGC GTGTGGCATG TGTACACGCC TGGGCCTCCT 180

TATCACAAAG TGTGCTCTCT CAGTGTTTAA ATACACACAA TCCACATCGA CTCGAG 236

60
120
180
240
300
360
420
428

60
120
180
240
269

224

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(2) INFORMATION FOR SEQ ID NO: 402:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

. {xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 02:

GAATTACCTT ATACACATAG CCTGAAGGTA ATTTTATACA ATATTTCCAA TAGTTTTGTG 60

CTTCAAACAA AGTTTGGGTA CATTGAACCA TCAGAAAGGA AAGGTGTCAT TGTCTCAGCC 120

ACCCATGTGG ACAATCTCTG GTTGTTTGGC AT CACTG TTG TTGCTGAGTC TGAATGTGAG 180

GAACATGCCA TTGGCATGTC TTGCCCACAC ACACACCATT TTGTTATCTT TTGTGGGTGT 240

GCTTATGTGG GGGAATCTGG GCGTGTGTGA AAAAAATATA TTGCAGCTCG AG 2 92

(2) INFORMATION FOR SEQ ID NO:403:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 345 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 403:

GAATTCGGCC TTCATGGCCT ACTTGGGGTA CTGAGATACA TGGGGCCGAA AAGGGGTAAT 60

ATGGCCATCT TTTATCAGAA AAAG TGACAA AACGGGAATT TAAAAAATGA ATTTT CCAT C 120

TGACTTTATT TCCAAATACA CTTTCTTTTT TAAAAAACCA ATACACTTTC TTTGAGGATG 180

ACAGTATTAG GAAATCCAAT TATACAAAAA ATACTACATC TAGTCTGGGG TAGATATATT 240

TATTTTTGGT AACATACATT AAGTGG CACT AATTACACAG TAACTATAAG GTAAC TAACA 3 00

TGAAACCACA GAACTGTAAC TCTGCCACAG CTG CATGAAC TCGAG 345

(2) INFORMATION FOR SEQ ID NO: 4 04:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 252 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

Mi) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:404:

GAATTCGGCC TTCATGGCCT AAAAAAAAAA AAGCCATTAA TCTAATTAAT TGTTTAATCC 60

TGCTTACAAG ATTATCTTGA AAAAATGTGC TGGGGAGTAT GGTATAATGA ATTACGGGTC 120

CAAGAATTTG GG TT CAG ATA CCACCTTCAG TCTTTACTAA GCTGCGTGAC TT TAG CAAAG 180

TGCTTAGTCT CTCTAAGCTT CGGTTTCCTA AT CTATGAGG AGGGCCTAAG ATATCACCAC 240

CCATCACTCG AG 252

(2) INFORMATION FOR SEQ ID NO: 4 05:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 05 base pairs

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{ B ) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 405:

GAATTCGGCC TTCATGGCCT AAGAATACGA AATTTGAGAG GATGAATTTG ACCTTTAATA 60

TTGTTGGACT TTGTATTGGA TATCTTTCCT CCATCACTTC AAAATCGTCT TGCTTGGCCT 120

CTTATTGCAA CCACAGCTGC AGTAGACAGT TCCATACAAG CTTCCAAGAA CTTCATGGGT 180

ACATCTGGAG AGCACCTCAC CTGGGGCCAC ATTCTCTACC TTTCCTGTCT TACTCTTCCT 24 0

CCTCTGGGCT TCTTTCTGGT GCATGGGGGT GGGGGGAGAT ATTAAGTATT CCCCAACAGC 3 00

TCGAG 3 05

(2) INFORMATION FOR SEQ ID NO:406:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 406:

GAATTCGGCC TTCATGGCCT ACACAGCAAC AACCAACATA GCTAATACAG AAAGCAGTCA 60

GCAGACTCTA CAGAATTCCC AGTTTCTTTT AACAAGGTTG AATGATCCTA AAATGTCTGA 120

AACGGAG CGC CAGTCCATGG AAAGCGAGCG TGCAGACCGC AGCCTGTTTG TCCAAGAGCT 180

CCTTCTGTCC ACTTTAGTGC GTGAAGAGAG CTCATCCTCA GATGAGGATG ATCGGGGGGA 24 0

GGTTCTCGAG 250

(2) INFORMATION FOR SEQ ID NO: 4 07:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 81 base pairs

(B) TYPE: nucleic acid,

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ i i ) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 407:

GAATTCGGCC TTCATGGCCT AAAAGAAACT AGGTGTGATT GGAAGGAAGA ATCATGAAAG 6 0

ATCAGGGTAG ATACTGGTGG GGCAGCTATT AAAGGAGTTT GAGCAGGGGC ATGACAT CTT 120

CACATTGAAA GCAATATGGG AG TCG AATTA AATTTAGTAC CCAGTTGAGA TAAAAGT CCA 180

TTGCCATATT CACAGTGAGG TGGGACAAAA GCAGAGTCAG AGAGATTAAG AGGCTGGGAA 24 0

AGATTGAAGT GATTTTTAGG AATCAGAATC CACATCAGTT GATGACAAGT ACAGAAGGGC 300

ACAATAGCAA GAAGAAGAAG TAAATGATAA TTCCTAGATG CCATTAGTCA CAATCAAGTA 360

CGGAAGAGAC ATTATTGACT GAGGTTGAAT CAGGGCAGAG AAGATAATAT ACCTGATTTT 42 0

GGAAGTGTTG CATGTAAGGG GGCTTCGATT TCAGCTACTT ACATACTTGG GAAGTCTCGA 480

G 481

(2) INFORMATION FOR SEQ ID NO: 408:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 08 base pairs

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(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 08:

GAATTCGGCT TCATGGCCTA CCCGGCAATT GGCTGATCCG CAGAAACATT TCTGGGCTTC 6 0

TTTTCCATAT CTCTGGAACT G ATAGT C AAA CGTTAACTCT GAGCCTGAAG GAACCAGTTT 120

GGTGGTAAAA AACCCAACCC TCAGTTGTCC GTTCACAGTC CATTTTTGGG TTTCACAATT 18 0

TGGTTCACAG CTGTGATTCA TGAAACGAGA GCAATTTCCT TTTTGAGTGG CATCTATTAT 24 0

CTCATCATTC TTCAGGGCCA TGAAATAGTA ATGGATGTTT TTGTTTCGTG CATACTCCTT 300

CACTCGAG 308

(2) INFORMATION FOR SEQ ID NO: 40 9:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 37 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 09:

GAATTCGGCC TTCATGGCCT ACAATGAGGA TAATACAAAA GAG CAATCTG CCCCACTGTG 60

AGCCTGAGCT TCCCATACTG ACTTCTCTCT CTCCAGAGGG ATCCACTCCT ACCAGTCTGG 120

AAAG CACTGG GCATACAAGC GCACAAATGC GTGGCACATA CTACAAATCC TTCTAAAGCC 180

ACTGCTGTAC ACCTGCCTCA CTTAACCATG CAGCCTCAAG GCTGTCTCAT GTCATTCTTT 24 0

CCTACAGCTG CAGAGTTTTC AACATATGGA CAGGTGTGCC AGGATTTATT TGACTAGTCT 3 00

CTTACTGATC TAGCTCACCT CCTAAATACA ACTCGAG 337

(2) INFORMATION FOR SEQ ID NO: 410:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 315 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 410:

GAATTCGGCC TTCATGGCCT AAAATGTGGG GATTGGGAAC CACTAGTTCT TTCAGATGGT 60

ATTCTTCAGA CTATAGAAGG AGCTTCCAGT TGAATTCACC AGTGGACAAA ATGAGGAAAA 120

CAGGTGAACA AGCTTTTTCT GTATTTACAT ACAAAGTCAG ATCAGTTATG GGACAATAGT 180

ATTGAATAGA TTTCAGCTTT ATGCTGGAGT AACTGGCATG TGAG CAAACT GTGTTGGCGT 240

GGGGGTGGAG GGGTGAGGTG GGCGCTAAGC CTTTTTTTAA G ATTTTT CAG GTACCCCTCA 3 00

CTAAAGG CAC TCGAG 315

(2) INFORMATION FOR SEQ ID NO: 411:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 277 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

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(D) TOPOLOGY: linear
(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 11:

GAATTCGGCC TTCATGGCCT ACCTGAACCC CTTACTTCGA AGGATCATAA GATTCACAGG 60

GGTGTTTGCA TTTGGACTTT TTGCTACTGA CATTTTTGTA AACGCCGGAC AAGTGGTCAC 120

TGGGCACTTA ACGCCATACT TCCTGACTGT GTGCAAGCCA AACTACACCA GTGCAGACTG 180

CCAAGCGCAC CACCAGTTTA TAAACAATGG GAACATTTGT ACTGGGGACC TGGAAGTGAT 24 0

AGAAAAGGCT CGGAGATCCT TTCCCTCCAA ACTCGAG 277

(2) INFORMATION FOR SEQ ID NO; 4 12:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 316 base pairs

(B" TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 12:

GAATTCGGCC TCATGGCCTA GTGGTAGGGC TGAATTCGCA CTATAGGGTT AGATTTTCTA 60

CTGTAGGGTT AGATTTTTTT AATGGTGTGT ATATAATAAT ATAATATTAA TAATAATCGG 12 0

AGAGGGTCAA AGAGGAGGGA AACTGGGTAA CCCAAAAACA TAAGGTCGAG GTCCCTGTTC 180

TTCACCGGAA AGAGGGTCAA GGACCAAAGC CATAGATTTG ACTGGTAGTT TAGTTTAGTC 240

CTGTCTACGA AGAAGAAGAG CGGTTGTTTG TTTTAACAGA TTCAAGAGCA GGAAG CACTC 3 00

ATTTAGATAA CTCGAG 316

(2) INFORMATION FOR SEQ ID NO:413:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 9 base pairs

(B) . TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 13:

GAATTCTAGA CCTGCCTCGA GTCAGGCTTT TAAAAACAAT CTCATCTGTC CCTCTAAAAA 60

TTAGCTTCCT TTAGAACCTC TTCTCCTTGG CAATATATTA GTGATACTAT TGTTATCTTC 12 0

ACACTAAAGA TTCAAAACTT TAGTTTTTGT TTTAGGAAAG TTTTTTATTT TTACATTTCT 180

TTCATCCTTC ATAATTACCC AGTCATCATG AACTTTGTAG TTATCTATTT CTTCATAGGA 24 0

ATCCTCGAG 24 9

(2) INFORMATION FOR SEQ ID NO:4l4:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

228

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO:414:

GAATTGATAC TAGGGACCGA AGGGAACTAA GAGACTCCAG AGACATGCGG GACTCAAGGG 60

AGATGAGAGA TTATAGCAGA GATACCAAAG AGAGCCGTGA TCCCAGAGAT TCTCGGTCCA 120

CTCGTGATGC CCATGACTAC AGGGACCGTG AAGGTCGAGA TACTCATCGA AAGGAGGATA 18 0

CATATCCAGA AGAATCCCGG AGTTATGGCC GAAACCATTT GAGAGAAGAA AGTTCTCGTA 24 0

CGGAAATAAG GAATGAGTCC AGAAATGAGT CTCGAAGTGA AATTAGAAAT GACCGAATGG 3 00

GCCGAAGTAG GGGGAGGGTT CCTGAGTTAC CTGAAAAGGG TAGG CTCGAG 3 50

(2) INFORMATION FOR SEQ ID NO: 415:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 529 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:415:

GAATTCGGCC TTCATGGCGT TAAAACTGTG CCTAACAGAG GTGTCCTCTG ACTTTTCTTC 6 0

TGCAAGCTCC ATGTTTTCAC ATCTTCCCTT TGACTGTGTC CTGCTGCTGC TGCTGCTACT 12 0

ACTTACAAGG ' TCCTCAGAAG TGGAATACAG AGCGGAGGTC GGTCAGAATG CCTATCTGCC 180

CTGCTTCTAC ACCCCAGCCG CCCCAGGGAA CCTCGTGCCC GTCTGCTGGG GCAAAGGAGC 24 0

CTGTCCTGTG TTTGAATGTG GCAACGTGGT GCTCAGGACT GATGAAAGGG ATGTGAATTA 3 00

TTGGACATCC AGATACTGGC TAAATGGGGA TTTCCGCAAA GGAGATGTGT CCCTGACCAT 360

AGAGAATGTG ACTCTAGCAG ACAGTGGGAT CTACTGCTGC CGGATC CAAA T CCCAGG CAT 42 0

AATGAATGAT GAAAAATTTA ACCTGAAGTT GGTCATCAAA CCAGCCAAGG TCACCCCTGC 4 80

ACCGACTCTG CAGAGAGACT TCACTGCAGC CTTTCCAAGG ATGCTCGAG 529

(2) INFORMATION FOR SEQ ID NO: 416:

<i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 63 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 416:

GAATTCGGCC TTCATGGCCT ACTGAGCCTA GTAATTCAAG GCTGCAGTGA GCTGCGATCA 6 0

CATCACTGCA TTCCCGCCTG GGCAACAGAA GTAGACTCCA TCTCTAAAAA GAAGGAAAGA 120

AAAAAAGGAA GAAATATACA GTAATTTTAA ACTGGGAGAT GAAATGCTAA TTTCTAGAAG 180

TCCATTTGGT TTTGAAGGGT CTCATGTCAA AAAAAAAAAA AAGTAAGTAA AATAAGACCC 24 0

ATCCTACTGT TTTATATACT AAAATAGTAA GTTAATTAAA TGAAAATGAA GTACATTTGG 30 0

GCTTTCATTT ACCAATCCTG GAATGTTGAA AAGTTGCCCA AAAGACATTT AGCAAGACTC 3 60

GAG 3 63

(2) INFORMATION FOR SEQ ID NO: 417:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 129 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

229

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<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 17:

GAATTCGGCC TTCATGGCCT ACCTGAAAGC CCATCTCCTC CAACTTGCAG CGCCGGTAGA 60
GCTCGTAGTG CCGGCTGTGG GTCTGCTCGC GGAGGTCTTC CATGTTCACC CGGATCAACC 120
TGCCTCGAG 129

(2) INFORMATION FOR SEQ ID NO:418:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 284 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 4 18:

GAATTCGGCC TTCATGG CCT AGGAGGTGGG TATAGGGAAC ACTTGGGGAG AAATAGTGAA 6 0

ATCTGAATAT AGACTGTGCA TTGTATCATT TAGTATAAAT GTTGACTTGC CTGATTTTGT 12 0

TGTTGAAGGC ACTGTGGTTA CACAAGAGAA CGTCTGTCTT CCTAAGTGAT GCATGCCAAG 180

GTTTGCAGGG GCATCCTGTC TGCAATTACT CTCAAATAGA TCAAAATAAT AATAACGTGT 24 0

GTGTGCATGA TGGAGACAGG GAAGAAGAAA GGAAAGGGCT CGAG 2 84

(2) INFORMATION FOR SEQ ID NO:419:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 92 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 19:

GCCAGCACAT TGTGGAACAG AAAAATGGCA AAGAAAGAGT GCCCATCCTC TGGCATTTCC 60

TGCAGAAGGA AG CAGAGCTG AGGCTGGTAA AGTTCCTGCC TGAGATTTTG GCCTTGCAAA 120

GGGATCTAGT GAAGCAGTTC CAGAACGTCC AG CAAGTTG A ATACAGCTCC ATCAGAGGCT 180

TCCTCAGCAA GCACAGCTCA GATGGGTTGA GGCAG CTGCT TCACAACAGG ATCACAGTCT 24 0

TTCTGTCCAC ATGGAACAAA CTGAGGAGAT CG CT TG AG AC GAACAGCTCG AG 292

(2) INFORMATION FOR SEQ ID NO: 42 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 420:

GGAACCAACA GAACAACCTG TGAGGAAGAA CAAAATGG CC TCTAATATCT TTGGGACACC 60
TGAAGAAAAT CAAGCTTCTT GGGCCAAGTC AGCAGGTGCC AAG TCTAGTG GTGGCAGGGA 120

230

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AGACTTGGAG TCATCTGGAC TG CAG AG AAG GAACTCCTCT GAAGCAAGCT CCGGAGACTT
CTTAGATCTG AAGGGAGAAG GTGATATTCA TGAAAATGTG GACACAGACT TGCCAGGCAG
CCTGGGGCAG AGTGAAGAGA AGCCCGTGCC TGCTGCGCCT GTGCCCAGCC CGGTGGCGCT
CGAG

180
240
300
304

(2) INFORMATION FOR SEQ ID NO: 421:

ti) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 256 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 421:

TAATT TAG AT TATACAGAAC TTGGCCTGCA GAAACTGAAG GAGTCTGGAA AGCAGCACGG 60

CTTTGCCTCT TTCTCTGATT ATTATTATAA GTGGTCCTCG GCGGATTCCT GTAACATGAG 12 0

TGGATTGATT ACCATCGTGG TACTCCTTGG GATCGCCTTT GTAGTCTATA AGCTGTTCCT 180

GAGTGACGGG CAGTATTCTC CTCCACCGTA CTCTGAGTAT CCTCCATTTT CCCACCGTTA 24 0

CCAGAGACAA CTCGAG ' 2 56

(2) INFORMATION FOR SEQ ID NO: 422:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 216 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:422:

GCGATTGAAA TGGATCCTCC AGCTCTTCCA CCAAAGCCAC CTAAGCCAAT GACTTCAGCA 6 0

GTTCCAAATG GAATGAAGGA CAGTTCTGTT TCTCTTCAGG ATGCAGAATG GTACTGGGGG 120

GATATTT CAA GGGAGGAGGT AAATGACAAA TTG CGGGATA TGCCAGATGG GACCTTCTTG 180

GTCCGAGATG CCTCAACAAA AATGCAGAGA CTCGAG 216

(2) INFORMATION FOR SEQ ID NO: 423:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 89 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 423:

GAATTCGGCC TTCATGGCCT AAAATTAATG AGTTGAACCT GTGACCACTG CATTCAAGAA 6 0

GAGTCACCCA AGAGAGAGGT GGGGAGTCGA ACAG AG CTCC TTTACTTTCT CCCACAGAGG 12 0

AAAAGGTGGA ATTCTGGGCT GGCTTTCCCT CACCAGAGGG TATC CCAAAT CTATGACAAA 18 0

AGAAAAATGC CAGTCTCTTT TGGAAAGTAG GGAATGCCCT AGTGATGCTG TATGAAGAAG 24 0

CAAGCCTCCA TCTTCCCCGG GGAAATTTGA AACCAAGATG GGGTCCTGTC AATGACCCTC 3 00

TAGCATTTAT TGAGTGCCTA TTAGACAGGT GGCCTTGGGC TTTGAAATGC AATATCTTAT 3 60

TTAACTTAAT TCTGAGAACG TATCTCGAG 389

231

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(2) INFORMATION FOR SEQ ID NO: 4 24:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 411 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:424:

GCCCGTGCTG ATG T CTTTGA AAGAAGGCTA TAAGAAGTCC TCAAAAATGG TATTTAAGGC 60

TCCCATCAAA GAAAAGAAGA GTGTTGTGGT CAACGGAATA GATTTATTAG AAAATGTCCC 120

ACCCAGGACA GAG AATG AG C TCCTTCGAAT GTTCTTCCGG C AG C AGGATG AGATTCGACG 180

G TTG AAAGAG GAGCTGGCCC AGAAGGACAT CCGCATTCGG CAGCTCCAGC TGGAACTGAA 240

AAACTTGCGC AACAGCCCCA AGAACTGTTA GCTCCCCAGC TGGGCTGTTT TCTAAGCCGA 3 00

TCTCTCCGTC GTTTCTACTC ATCCCTTAAC TTCTCCCTTA CCAGTGACCC CAGAGACAGA 3 60

GCCAGGACAG GAGTGGGGGC CAG CCTGAGG ACCCCCGCCT ACCACCTCGA G 411

(2) INFORMATION FOR SEQ ID NO-.425:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 425:

GGTACCAACA GGACACCCCG GTGGCCCCCC GCTTTGACGT CAATGCCCCG GACCTCTACA 60

TTCCAGCAAT GGCTTTCATC AC CTACGTTT TGGTGGCTGG TCTTGCGCTG GGGACCCAGG 12 0

ATAGGTTCTC CCCAGACCTC CTGGGGCTGC AAGCGAGCTC AGCCCTGGCC TGGCTGACCC 180

TGGAGGTGCT GGCCATCCTG CTCAGCCTCT ATCTGGTCAC TGTCAACACC GACCTCACCA 240

CCATCGACCT GGTGGCCTTC TTGGGCTACA AATATGTCGG GATGATTGGC GGGGTCCTCA 3 00

TGGGCCTGCT CTTCGGGAAG ATTGGCTACT ACCTGGTGCT GGGCTGGTGC TGCGTGGCCA 3 60

TCTTTGTGTT CATGATCCGG ACGCTGCGGC TGAAGATCTT GGCAGACGCA GCAGCTGAGG 420

GGGTCCCGGT GCGTGGGGCC CGGAACCAGC TGCGCATGTA CCTGACCATG GCGGTGGCGG 4 80

CGGCGCAGCC TATG CTCATG TACTGGCTCA CCTTCCACCT GGTGCGGTGA GCGCGCCCGC S4 0

TGAACCTCCC GCTGCTGCTG CTGCTGCTGG GGGCCACTGT GGCCGCCGAA CTNATCTCCT 600

GCCTGCAGGC CCCAAGGTCC ACCCTGTCTG GCCACAGGCA CCGCCTCCAT CCCATGTCCC 660

GCCCAGCCCC GCCCCCAACC CAAGGCTCGA G 6 91

(2) INFORMATION FOR SEQ ID NO: 426:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 42 6:

GCAGACCATA TATCGAAAGT TCTTTACTTG TATCAAGGTG AGAAAAAATT AGAAGAGATA 6 0

TTACCTCTGG GACCAAACAA AGCTCTTTTT TATAAAGGAA TGGCATCATA TCTTTTACCA 120

232

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GGACAAAAAT CTCCATGGTT TTTCCAAAAA CCCAAAGGTG TAATAACTTT GGACAAACAA 180

GTAATATCCA CGAGTTCAGA CGCCGAATCC AGGGAAGAAG TTCCCATGTG TTCAGATGCT 240

GAATCCAGGC AAGAAGTTCC CATGTGTACA GGCCCTGAAT CCAGGCGAGA AGTTCCCGTG 3 00

TATACAGATT CTGAACTCGA G 3 21

(2) INFORMATION FOR SEQ ID NO: 4 27:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 190 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 427:

GAATTCGGCC TTCATGGCCT ATATACTATC AAATGAAAAT AGCAAGATGC TACCATTTAT 60

ATTAAAAAGA GGACAAAATA TTAATATATT CATGGTTGCT TGTCTATGTG GAATATTTCT 120

GGATATATAC ATAAGAAGTT ACATTGGTTA CCTATGGGCA GGTTACTACT GGGTGGCAGG 180

TGGGCTCGAG 190

(2) INFORMATION FOR SEQ ID NO: 42 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 670 base pairs

(B> TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 42 8:

GAATTCGGCC TTCATGGCCT AGGCAAAGCT GGCCCTGACG CCTGGGTTTC TTGGCCCCAG 60

CTGCCCAGCA GGTGCCTCGA TTCCCTGCCC TTG TGACCTC CCAGGAAACA GAACTGATCT 120

GGGACACTAT GTCACCTCTC CTCTCATCTG GGGTCAGTCA GGGTTCGGGG GCTGCAGCAG 180

CCAAGCGCAT GAGAGGTGTT TCCTTGGCCT TCCAGAAGGC CCACTGTGGA GCCAGCCTCC 24 0

CTATGGGAGG CAGAG CGGCA AGGACAGGGC TTTGGAATCA GCCAGGTCGG CTCCTGGGCT 300

GTGGCCGTGG AGAAACACTG CCCCCAGGAT GACACAGGCA AGAG CCCCTG AGG CATGGG A 360

GGCCCAGGGA AGACCATGGG CTGTAGGGGA GAGTGTGGCA GGTGACCCAA AGGCCCAAAG 42 0

AGGGCCGTGG GGCCTGAGGA GGT CATAATC TCTTCTGAGT GGGGGCAGGT CGATTCTTGC 480

ACAAGGTGGG CTCTTCACTG AGCCATAAGG GACAGGGAGG TATGGGAGAG CGCTGGGGGC 540

CCATCCCCCT GTCCACCCAG TGTCCACTGG CCTGTCCTTC AGGGAGCAGA GCAGAGCAGG 600

TGGTGGACGG GCCCAGTGCT GGGTGTTTTC ACCACCATCC CCCCATCCCC CATCTAAGTC 660

GCTCCTCGAG 670

(2) INFORMATION FOR SEQ ID NO: 42 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 429:

233

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GTAAGGATTG GCGATTCCTA CAGCGAATGA TCACCGCTCC CTGCATCCTC TTCCTGTTTT
ATGGCTGGCC TGGTTTGTTC CTGGAGTCCG CACGGTGGCT GATAGTGAAG CGGCAGATTG
AGGAGGCTCA GTCTGTGCTG AGGATCCTGG CTGAGCGAAA CCGGCCCCAT GGGCAGATGC
TGGGGGAGGA GGCCCAGGAG GCCCTGCAGG ACCTGGAGAA TACCTGCCCT CTCCCTGCAA
CATCCTCCTT TTCCTTTGCT TCCCTCCCCA ACCTCGAG

60
120
180
240
278

(2) INFORMATION FOR SEQ ID NO: 4 30:

(X) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 299 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(XI) SEQUENCE DESCRIPTION: SEQ ID NO: 430:

GAATTCGGCC TTCATGGCCT AATTGAATTC TAGACCTGCC TCTGTTCATC TTTAAATGCT 6 0

GTTTTCTCTG TTCAAAATGC CCTTTCCTAC CTTATCTACT TGTGC CACTG CATATT CCTA 120

AGGCTCAACT CAGGGTATCT TCCCTCGGAA ACCTTGTCTG AT CATC CTGG CCCCTCTGGC 180

GGACAGTAAT TTCTGCCTCT GTGCTCCCAT CACCTGAGCA CACCTGTATG GTGCTGCTGA 240

GCCCGCTGAA TTGGCATTAT GGGCACGTGC GTCTCCTCCA TTCCATGGAG CTCCTCGAG 2 99

(2) INFORMATION FOR SEQ ID NO: 431:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 431:

GTTACATGAC ACTGTTAATG ATTG CATTTG GCTTGCTGTG GGGGCATCTC TTGCGGATCA 60

AACCCACGCA GAGCGTCTTC ATTTCCACGT GTCTGTCCTT GTCAAGCACA CCCCTCGTGT 120

CCAGGTTCCT CATGGGCAGT GCTCGGGGTG ACAAAGAAGG CGACATTGAC TACAGCACCG 180

TGCTCCTCGG CATGCTGGTG ACGCAGGACG TGCAGCTCGG GCTCTTCATG GCCGTCATGC 24 0

CGAC TCTCAT ACAGGCGGGC GCCAGTGCAT CTTCTAGCAT TGTCGTGGAA GTTCTCCGAA 3 00

TCCTGGTTTT GATTGGTCAG ATTCTTTTTT CACTAGCGG C GGCTCTCGAG 3 50

(2) INFORMATION FOR SEQ ID NO: 432:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 05 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 43 2:

GAATTCGGCC TTCATGGCCT ACCAGGTTCT TGCTGCCCTG CGACTCCAGT AT CTGCAGGG 60

GGATTATACT CTGCACGCTG CCATCCCACC TCTCGAAGAG GTTTATTCCC TGCAGAGACT 120

CAAGGCCCGC ATCAGCCAGT CAACCAAAAC CTTCACCCCT TGTG AACGG C TGGAGAAGAG 180

GCGGACGAGC TTCCTAGAGG GGACCCTGAG GCGGAGCTTC CGGACAGGAT CCGTGGTCCG 240

234

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GCAGAAGGTC GAGGAGGAGC AGATGCTGGA CATGTGGATT AAGGAAGAAG TCTCCTCTGC 3 00

TCGAG 3 05

<2) INFORMATION FOR SEQ ID NO: 43 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 273 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 43 3:

GAATTCGGCC TCATGGCCTA CTCCTCAGCC CCTCATCTTG CCTCCACCCA GCTGCTCCAT 60

TTTTGCCACA TCGTGGCCCG CAGCCCCAGA GTCACTGTCC ATGTCACCAT CCTCCTCCTC 120

CTTTGGAATC CTCTCCGCAC ACTGTGGCCC TTGTCTCAGG GCCCACAAGC TGAACTGTGG 180

CATAGCTCTC TCTTCTTCTC CAAGAAGACT CAGCAGCCTA CATTCCCATT CCTGGTATGT 240

GCCATTGGGT TGGATGTCCC CACTTATCTC GAG 273

(2) INFORMATION FOR SEQ ID NO:434:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 434:

CGAGTGAGCG GGCGGGACAG TGCTTGTGAA ACTGAACACA ACAAAAGTAT GGATATGGGA 60

AACCAACATC CTTCTATTAG TAGGCTTCAG GAAATCCAAA AGGAAGTAAA AAGTGTAGAA 120

CAGCAAGTTA TCGGCTTCAG TGGTCTGTCA GATGACAAGA ATTACAAGAA ACTGGAGAGG 180

ATTCTAACAA AACAGCTTTT TGAAATAGAC TCTGTAGATA CTGAAGGAAA AGGAGATATT 24 0

CAGCAAGCTA GGAAGCGGGC AGCACAGGAG ACAGAACGTC TTCTCAAAGA GTTGGAGCAG 3 00

AATG CAAACT ACCCACACCT CGAG 3 24

(2) INFORMATION FOR SEQ ID NO: 43 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 43 5:

GAATTCGGCC TTCATGGCCT AAATGATCAA ATTTTGG CTT ACATAT TTTG CAACAGTGGT 60

ATAACACAAA GAAGTAAGCA AATATGG CAG AAGTGTGGTG GCTTTGGCGT CTACTTTTGA 120

CCATAGTGGT GGCCCTGTTA TTCGTGGCTC CCGGGGTTCC TACACATCCT TCCCGATGGA 180

AGAAGGGGTT GGCCAAAAAG GTCAGCCAGC TGATGGGTTG GACCAAGAAA GACAGAGTGA 240

TAAGAATGAG TGACACCATG TTCTATCATT TTGTATTAGA TGCACCAAAA AACTATTCTG 3 00

TTATTGTGAT GCTTACTGCT GCTCTCCACG CGTTCAGTTC ATGTGTCATG TGCAAAGGTG 3 60

CTGCTGAAGA ATTTCAGATC TTGG CAAATT CCTATCAACG CCCTGGTGCA TTCACCACAA 420

235

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AGGTATTTTT TGCAATGGTG GATTATGATG AAAGCCCTGA GGTCTTTGAA GCGCTCCAGG 4 80

TAACGTCAGT TCCGAGTTTC TTCCACTTTT CTGCCCAATG GAAATTTACA ACAGATGACA 54 0

GTCTCGAG 54 8

(2) INFORMATION FOR SEQ ID NO: 436:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 308 base padrs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 436:

GAATTCGGCC TTCATJGCCT AAAATGAAAT TCAGACAAAA TCACTGGCAC CAAAAATGGT 6 0

TTATTCTGAG CTGTCTTCAC TTTGACTATT TGGGGGGCTT CTCTCAAGTA CAGATGTGGG 120

TTGGGGTCCC CTGGAGCAGG CAGGATTGGC AGTAAGAGAT ATTGGCCACT CAAGTCTACT 180

GTGTGTGTGT GCCTCTGGAA GAGTGAAGAA TGGACTTCAA AAGTAACATC AAAAATCTAA 240

CTGCCACCAT CCTGGAGACA TTTTGCAGGG CTTTCCTTTC AAGTCTTTCA AGTACAGGAC 3 00

ATCTCGAG 3 08

(2) INFORMATION FOR SEQ ID NO: 437:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 420 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:437:

GAACAGAAGA GATCCCCTCG GCCCCCACGC CATATGACCA AAGTCACACC AGGTTCAGAG
CTGCCCACTC CCAATGGAAC CACCTTATCA TCTAACCTCA CTGGTGGCAT GCCCTTCATT
GATGTGCCCA CTCCCATCTC CTCTGCAAGT T CAGAAG CTG CCTCAGCAGT GGTCAGTCCC
TCTACAGACA GTGGCCTGGA ATTCTCCTCC CAAACCACTT CCAAGGAAGA CCTTACTGAT
CTAGAGCAAC CTGGCTCTCC AGGGTACAGC ACAG CTACAG AGC CTGGAAG CAGTGAGCTA
GGTGTTCCCG AGCAGCCTGA CCTCCAGGAA GGGACCCATG TGGAAAAGTC CCAGTCAGCA
TCTGTGGAGT CCATCCCTGA AGTGTTAGAG GAGTG CACGT CCCCTGCCGA CCAACTCGAG

(2) INFORMATION FOR SEQ ID NO; 43 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 279 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO:438:

GAATTCGGCC T TCATGG CCT AATTGAATTC TAGACCTGCT TCTCACTGCA CCTGGATGGC 60

AACGTGCTGG ACCACTTCTC GGAGCTGCGC AGCGTCGAGG GGCTGCAGGA GGGCTCTGTG 120

CTGCGTGTGG TGGAAGAGCC GTACACGGTG CGTGAGGCCC GCATCCACGT GCGCCATGTC 180

CGAGACCTGC TCAAGAG CCT GGACCCATCC GATGCCTTCA ACGGGGTTGA CTGCAACTCC 240

60
120
180
240
300
360
420

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TTGTCCTTCC TGAGTGTCTT CACCGACGGC GACCTCGAG 279
(2) INFORMATION FOR SEQ ID NO-.439:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 51 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:439:

GAATTCGGCC TTCATGGCCT AATTGAATTC TAGACCTGCA CCCAGCCTTC TTCTTTTCAT 60

TATAACCTTT ATACCACAGT AAGCTGTTGC ATCATTCAAA TGACTCTGCA TCCTATATTG 120

AATATTCTCC ATTATTCTCT AATATCTTTG GGGGTACCCA GGATTACAGG GTTCTGGGCA 180

TACATGTTAA TGCTTTTGCC AGGACTTTTC TTTTTATTCA TTGTCGTGAC CCATTGTCTT 24 0

TGCTTATATT TAAAGTTTTT GCTCTTGATA TCATTGGTTC TTTCCTAAGT CACTTTTTCT 3 00

GGTAACTGCT TTGGAATGAA TCATACATAT CTCACTTACG GAGCTCTCGA G 3 51

(2) INFORMATION FOR SEQ ID NO: 440:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 412 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi> SEQUENCE DESCRIPTION: SEQ ID NO: 44 0:

GAATTCGGCC TTCATGGCCT ACCAATACTC ATAATTAAAA GTTTTTCGTT GTCAAAACAT 60

TTTCACAGTT CAGGAATCAC AGTCCTATTT CATCTTTTGA AATAAAAGTT AAAGTCCATT 120

TTTCTTAAGC CTTATTATAC CATTATCCAA AAACACTACC TAGCATTCAT CTTAGTTTTT 180

CATATCTCCT TAGCAGATAG TTTAGTATAT TCCATTTGTC TTATTTGAGG TTTAAAAAAA 240

GTTGTGGAAG AAGTTTCTCA GGAGTTCAGC AAGCCTTTCC ATCTATCTTC TATTTTAAAA 300

GAATGTGATT TATTGTTTTT ATGAATAAAA TAT AC CTCGT GTGTTTCTCA TATGATGTTC 3 60

CATTACATTA ATCATCCATT AAGTAAATGT TTTTGTGCTG CAAAAACTCG AG 412

(2) INFORMATION FOR SEQ ID NO: 441:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID- NO: 441:

GAATTCGGCC TTCATGCCTA GCCAGGAGGA GGAGGACCCT ATGAACAAAC T CAAGGG CCA 60

GAAGATCGTG TCCTGCCGCA TCTG CAAGGG CGACCACTGG ACCACCCGCT GCCCCTACAA 120

GGATACGCTG GGGCCCATGC AGAAGG AG CT GGCCGAGCAG CTGGGCCTGT CTACTGGCGA ISO

GAAGGAGAAG CTGCCGGGAG AGCTAGAGCC GGTGCAGGCC ACGCAGAACA AGACAGGGAA 24 0

GTATGTGCCG CCGAGCCTGC GCGACGGGGC CAGCCGCCGC GGGGAACTCG AG 2 92

237

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(2) INFORMATION FOR SEQ ID NO:442;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 222 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 442:

GAATTCGGCC TTCATGGCCT ACCGCCTCGC TGCCTGGACA CCTGTCCGTG CCACCCTGGT 60

CACTGAGCAG GACATCCGCG TCTGTGGCCC CTGGGACCCT GCCCCCGACA GCCAGGCCTG 120

GGTTTGTCCT TTTAGGTAGA GTGCCTGGTC CAGGTCATTG GAGGAGAGTC CACATGGCCA 18 0

CCTCTGGCGT GTTCTAGAGA GGCCCTCCCG TCTAGGCTCG AG 222

(2) INFORMATION FOR SEQ ID NO: 44 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:443:

CTTTATGACA GCCATGAGCT TTTTCCGGTG CATTGCAATT GTTTTTCCAG TCCAGAACAT 60

TAATTTGGTT ACACAGAAAA AAGCCAGGTT TGTGTGTGTA GGTATTTGGA TTTTTGTGAT 120

TTTGACCAGT TCTCCATTTC TAATGG CCAA ACCACAAAAA GATGAGAAAA ATAATACCAA 180

GTGCTTTGAG CCCCCACTAC TCGAG 205

(2) INFORMATION FOR SEQ ID NO: 444:

(2) INFORMATION FOR SEQ ID NO: 44 5:

60
120
178

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 178 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:444:

GAATTCGGCC TTCATGGCCT ACCTGCCTCC CTCCTTGCTT CTTGCTCTGC TAACTCAACT
CTGCCTTCCT CTTTTTCATT CTTCTACTCT GCC CTATATG GAGGACAAAT GGACACCAGG
GGTGCTAACC TTATTGGTGC CTGCCCCAGC CTACCCCAGG TGCAAGCAGA CTCTCGAG

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 251 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

238

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 445:

GAATTCGG CC TTCATGGCCT AGAAAGCCAC AAACTTTTTA GTTTTTAACT TCAAAGGCTT
CTTTCTCTTT AAAAAAAATT ATTTTTAATA TAGAGTCAAA AAATTGGATG TATTATTTTG
AGCTTCTAAT TGCTGCCACT TGGAGATGTC CAAGTAAGAA GGCCTTCTTT TTACATGGGA
TGAATTGTGC ACTTCTACTG ATGATGACTA CAG CAGAAGT GATGTTATAC GTACAGGCAC
TTGAACTCGA G

60
120
180
240
251

(2) INFORMATION FOR SEQ ID NO:446:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 01 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:446:

GAATTCGG CC TTCATGGCCT AGGG CTTATA TTTTAACTGA ACTATTATTA AATAAAAACA 60

AAATAAAATC TTATCATATA GGTGTAATCT GTTCTAAGGA AAAAATCCTT CTATCAAGAC 120

TAAACGTCTA ACTGAATACA GAATGACATT TCATGCCTTA AGGTCTCTGT CCATGTTGTT 180

CCTTCTTTCT ACTGTCCTTT ACTGTATTAG TTCAAAACAT TCTAATTCAC TCTCCAAAAC 240

CCAATTCAAA CATCACCATC AGAAAGTCTT CCATGATGGG CCAGGTGTGG CGGCCCTCGA 300

G 301

(2) INFORMATION FOR SEQ ID NO: 447:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 150 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 44 7:

GAATTCGG CC TTCATGGCCT AGCTGAAATG CTTTCTATTG GATACTATCT GGGCATATTA 60
CTTCCTGTGG TTCACTGTCT GGGTGACAGG ATTCATAGAA GCCCAAACTT TAGCACCACG 120
CAGCATACCC TTGTAACAAA GCCACTCGAG 150

(2) INFORMATION FOR SEQ ID NO:448i

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 226 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 44 8:

GAATTCGGCC TTCATGGCCT AATTTGATTT TATTAGGTTT AAATTGTATT TCTTCAAATT 60
T CATAAACT A TAGCATTTAT CTCCATATTT TTAATAAATG ATCACAAATA AATCACTGTT 120
AATATCTCCA TTTACACTTT TACAACTCCT GCTATTGCTG GATTTTTCAT CCTATGATAT 180

239

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GTTAAACCAA TTTAAAATAC ATTTAAAGAA TCACAGCTGT CTCGAG 22 6

(2) INFORMATION FOR SEQ ID NO: 44 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 453 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 44 9:

GAATTCGGCC TTCATGGCCT AAGACTGGGG GCATGTACCC CACCTACTTT CTGCACCTGG 60

ACCGTGAGGA TGGGAAGAAG GTAAGGTTGG TCTGGGCATG TTATCATCTA GGCTTTACAG 12 0

CCCTTTGAAA TCCTAGGGGC TGAAATGTGA CTGGAAGTCT CATATCTACC GCTGACCTCT 180

CAGTTCCTCA AAGAAACTGC CTTCGTGTCT GGTCTGTGCA CATCTTTGTG TTTTCCAGTG 240

CATTTGTGTG TGTGCACATA TGTGCGTTTG GGAGCTGACG CAACGGAGAG AGTCTGTGTG 3 00

AGTGGCTCTC ATGACTGTGT GCAGACCAGA GGCTGAGTCT GGAATATGAC CTCATTCCAC 360

TCCCCAAGGT GTTCCTCCTG GCGGGAAGGA AGAGAAAGAA GAGTAAAACT TCCAATTACC 420

TCATCTCTGT GGACCCCACA GACTTGTCTC GAG 4 53

(2) INFORMATION FOR SEQ ID NO:450:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 246 base pairs

(B) TYPE: nucleic acid
{C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 50:

GAATTCGGCC TTCATGGCCT AAAAGCAAAT TAACTTGTTC TGAAAAGAAA GTATAGATTA 60

ATTTTGTTTT CTGTTTAAAT TTTATCTCCT TGGTAAAGAT TTTTTTTTCC TGGG CAGAAA 12 0

ACTTGGCATT TTTAGGCGTA GATACCTTAC CTTACAATGC CAAAATGAAT TTAATTC CAG 180

TACTCAGGTT TTTCCCTTTA ACAGACTCTA TGTGTACCAG GCATTGAATT CTAGACCTGC 24 0

CTCGAG 24 6

(2) INFORMATION FOR SEQ ID NO: 451:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 414 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 51:

GAATTCGGCC TTCATGGCCT AGTTTGGTGG GGTTGAAGTT GATGGCAAAC T CATGGGAG A 60

CCTTCCAGTC TGGGGGTAAC TGGGCCCCGA ATCCCAGAGC TGGAAACATC TTATCACTGT 120

CGTAGTCCTG AATGATCTGC CCAACAGCCC AGATGGCCGA CAGATATTCG TTGGTGCCCA 180

TAGGGTTGAT ATAGTG CAAA GAGGAAGGGT CGAGGGGATT CCCGTTGGAG GCTGTAAAGT 24 0

CTATTCCAAC GGTGAACATG AGCTGGCAGC CTCCCAGGAT GTAGTCAAGG AAGGAGTAGT 300

CTCGGTTTAT CTTGCAGGAT CG CAGGATG A TGATGCCCGA GTTTTTATAG TTCTTCTTCT 360

240

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TCCTCTGCTT CTTGGGGTTG ATGCACTCGA ACTCCAGCGG GACGCTGTCT CGAG 414
(2) INFORMATION FOR SEQ ID NO : 452:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 374 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 52:

GAATTCGGCC TTCATGGCCT ACACACTGAC TGACAGACCA CGGTATGCCT TGCACCACCC 60

TGGCTGCTGG GGTCCAAAGA GGGATCTGGT AG AC CTGGG C TGGAATCTCA GCTTCACCAT 12 0

TTACCATCTG GGTGGCCAAT GGAGTGTTAC TTGGCCTCTC TGAGCCTCGG TTTTGCTCGT 180

CTCTGAAACA GTAAG ATAC C TCCCTTTGGC TGTTGTGATG AGGATGAAGG TTAGCCTATG 24 0

CCCAGTAGTA TGCCTGTCCC TTCATCGATG CCTGCTCATC TCACTCTTGC TCTGGAAACA 3 00

CCCCTAGTAG AGGCGCAGAG GGGCAGGGCC CACCCCACCC ACCAAAACGT GGTGCAGAAT 360

GAGGTGATCT CGAG 37 4

(2) INFORMATION FOR SEQ ID NO: 4 53:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 88 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:453:

GCGTCCGTCC GCCGCCACCA CCCACTCCGG ACACAGAACA TCCAGTCATG GATAAAAATG 60

AGCTGGTTCA GAAGGCCAAA CTGGCCGAGC AGGCTGAGCG ATATGATGAC ATGGCAGCCT 120

GCATGAAGTC TGTAACTGAG CAAGGAGCTG AATTATCCAA TGAGGAGAGG AATCTTCTCT 180

CAGTTGCTTA TAAAAATGTT GTAGGAGCCC GTAGGTCATC TTGGAGGGTC GTCTCAAGTA 24 0

TTGAACAAAA GACGGAAGGT GCTGAGAAAA AACAGCAGAT GGCTCGAG 2 88

(2) INFORMATION FOR SEQ ID NO: 4 54:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 83 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 54:

GAATTCGGCC TTCATGGCCT AAGAAGTGTC TCCTGTATCC ACCTCTTCCT GGCCTCCCTT 60

CCCCCACTTC CTGGTCCCTG TCCACTCCTC AGGTTGGTGC TCTCACTTCT TGAAAGCTCT 120

AGGCACCCCC GCCTCCCGCC AGGCTCCCCG TTGGCTCCTG GCAGGCCAGC TGAGAATGAA 180

CAGGAGATGG AGGCAGGCAG CCCAGGCTGC AGAGGTGAGG GATGTGGGGC CAGGCCCAGA 24 0

GGGCTCAGCC TAGAGGCTTC CAATCTCAGA TTCTCCTGCC TGTGGTCATC TGTTTGTCCA 3 00

TCACCCCAGG ACAGGG CAG A CAGAGGGGCA AAGCACTGGG GGCCCCAGAG CCTAGCTTCC 360

CCTCAGCCTG GGGGAAACTC GAG 3 83

241

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(2) INFORMATION FOR SEQ ID NO: 4 55:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 409 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 55:

AGAGCACGTC AATGCCATGA GGGGCCTGCA AAGC AG CAAG GAGCTCAAGG CTGAGCTGGA 60

CGGGGAGAAG GGCCGGGACT CAGGGGAGGA GGCCCATGAC TATGAGGTGG ACATCAATGG 120

TTTAGAGATC CTTGAATGCA AATACAGGGT GGCAGTAACT GAGGTGATTG ATCTGAAAGC 180

TGAAATTAAG GCCTTAAAGG AGAAATATAA TAAATCTGTA GAAAACTACA CTGATGAGAA 24 0

GGCCAAGTAT GAGAGTAAAA TCCAGATGTA TGATG AG CAG GTGACAAGCC TTGAGAAGAC 300

CACCAAGGAG AGTGGTGAGA AGATGGCCCA CATGGAGAAG GAGTTGCAAA AGATGACCAG 36 0

CATAGCCAAC GAAAATCACA GTACCCTTAA TACGGCCCAG AATCTCGAG 409

(2) INFORMATION FOR SEQ ID NO:456:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 317 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 56:

GAATTCGGCC TTCATGGCCT AAATTTCATG AAAAACAAAT GGCTTAAACC CAGGGAAGCA 6 0

AGGATTATAA TTGATTTTTT TG AG CAATGT CTCTTTTGGT TACAAAGTAA AAGGTAAAAT 120

AAAAGTTTAA AAGCATTTGG AAAGAATGTT CTTTGGTTTT TTCACTCAGT AACCTAAAGT 18 0

TTAATGACCC TTTACAGTGC TGATAAACAC TTAAATTTTT GCAGTAGGCA TTGCTAGTTC 24 0

AAATTGAAGG AAGGTTGCCA GGCTCATGCC TATAGTCCCA ACTACTTAGG AGGCTAAGGC 3 00

AGGGGGACGC CCTCGAG 317

(2) INFORMATION FOR SEQ ID NO: 457:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 510 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 57:

GAATTCGGCT TCATGGCCTA CTGCTCTTTG GCTAAGGTGG CAGTGTACCT CTAGATCAAC 60

CTGGGCAACA GTCACAAGGG AGTGTGACTT CTTGGCCATA ATAAACTCAC TTGATAGTGT 12 0

TTATGTTATT AATCTGAATG CAACAGAAGA CAAAAGCACA GGCATGCACA CACACAGAAC 180

CCCAAACCAC TAAAAACTAC CTAAACACTG ACTTAGTAAA TAGTAAAAAG GTAATGTTGG 240

GACTTTTAAA CCTTGAATCC ATTAGCCAGG CTTGGGATGA AAGGACCATC TAAAATCATG 300

CTAGTCTAAA CCATGCTCTT CCACACAGCT GTTTAAAAAC CACTGGG TAT GAGGAATATG 360

CTAGAAAGAA ATGTTAAAAA TAGATTGTTG GCTCACACTT ATTTTTCTAA TAAATAGGAC 420

CATTATTACT ACCAGGAAAG TCTTATTTAT TTTGCCTGAA ATTGGCTTAA AGAAAGTCTC 480

242

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ATGACGGGAT GGGATGGGCC GGCACTCGAG 510
{2) INFORMATION FOR SEQ ID NO:458:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 58:

GAATTCGGCC TTCATGGCCT AG CGG AAAC A ACTGAAACTA ATGGAAGATA TGGATACAGT 6 0

AATTAAACCC CGTCCTCAAG TAGTAAAACA AAAAAAACAG CGACCAAAAT CTATTCACAG 120

AGATCATATT GAATCCCCCA AAACACCAAT AAAGGGTCCT CCAGTCTCTA GCCTTTCTTT 180

GGCATCGCTG AACACGGGTG ATAACGAGAG TGTACATTCA GGCAAGAGGA CGCCAAGATC 24 0

AGAGTCTGTA GAAGGCTTCT TATCTCCAAG TCGTTGTGGC AGTCGAAATG GAGAAAAAGA 3 00

CTGGGAGAAT GCATCAACAA CTTCTTCAGT GGCTTCTGGA ACAGAATATA CAGGACCAAA 3 60

GCTCTACAAA GAACACCTCG AG 382

(2) INFORMATION FOR SEQ ID NO: 459:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 433 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 45 9:

GAATTCGGCC TTCATGGCCT ACTGAGTCCC AGGCCGGGGC CCTGCCCCAG CCAGGGCTGG CD

GACTCTGCAG TTGGGAGCTT GTCCAGCTGC CCCCTCTAAT GCTTTTCTCC TCCAGGACAC 12 0

AGGGAGCCTC CGGAAGCACA GTAGTCCCCG TGTGTCACCT TAGGCTGACC TCTGTCCCCA 180

GGGGTGACGT AATGCTGTCA CTGTCTTGAA TTCTTCATCG TTTAACAGGG AGCCCAGTGT 24 0

TTTCACCAAA AGCAGAATTG GATTTTTTTT TTAAGTCGAT AAATTTTTAC TCAAGGAATT 3 00

CCATGTTGTG ATTTCTTCCA CTGTCCATCA AGGTCACTTT AGATCCTCTA AAGAG CTAG A 36 0

GTCAAAAGAT TTATCTTCAA GTTAGTCCTT TTTAATGAAA CCGATGCTTA TTTTAATCCA 420

GTCAGCCCTC GAG 4 33

(2) INFORMATION FOR SEQ ID NO: 460:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 OS base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 46 0:

GTCCGGCTAA AGTAATCCAG TCACCTGCTG CTGATACTAG AAGGG CTGAG ATGTCACAAA 60

CAAATTTTAC CCCTGACACT CTTGCCCAGA ATGAAGGGAA GGCTATGTCT TATCAGTGTA 120

GCCTTTGTAA GTTTCTATCA TCATCCTTTT CCGTGTTAAA AGATCATATT AAG CAACATG 180

GTCAGCAAAA TGAAGTGATA CTGATGTGCT CAGAGTGCCA TATTACATCT AGAAG C CAGG 24 0

243

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AGGAACTTGA AGCCCACGTG GTGAATGACC ATGACAATGA TGCCAATATC CACACCGAAC 3 00

TCGAG 3 0 5

(2) INFORMATION FOR SEQ ID NO: 461:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 563 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 461:

GAATTCGGCC TTCATGGCCT AAGAAATATC AGTCCAAGCA AGAGGAATTA CAGAAAGATA 60

TGCAAGGAAG TGCACAGGCA TTGGCTGAAG TAGTGAAAAA CACAGAGAAC TTCTTAAAAG 120

AGAATGGTGA AAAGCTGTCA CAGGAAGATA AGGCTTTGAT TGAACAGAAA CTTAATGAAG 18 0

CTAAGATAAA GTG TGAACAG CTTAATTTAA AAGCAGAACA GTCTAAAAAG GAGCTGGATA 24 0

AAGTTGTGAC AACAGCAATC AAGGAAGAAA CTGAAAAGGT AGCAGCAGTG AAGCAGCTGG 3 00

AAGAGAGCAA AACCAAAATA GAAAACCTTT TGGACTGGTT GTCAAATGTT GACAAAGACT 360

CAGAAAGGGC AGGGACAAAA CACAAACAGG TAATCGAACA GAACGGGACC CATTTTCAAG 420

AAGGTGATGG CAAGTCAGCA ATTGGAGAAG AGGATGAAGT TAATGGTAAC CTGTTGGAGA 480

CTGATGTTGA TGGGCAAGTT GGAACCACTC AGGAGAATCT GAATCAGCAA TATCAGAAAG 54 0

TTAAGGCCCA ACATGGACTC GAG 56 3

(2) INFORMATION FOR SEQ ID NO: 462:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 77 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 462:

GCGGCTGTGA AGATGGCGGC GGCTGCGTGG CTTCAGGTGT TGCCTGTCAT TCTTCTGCTT 6 0

CTGGGAGCTC ACCCGTCACC ACTGTCGTTT TTCAGTGCGG GACCGGCAAC CGTAGCTGCT 12 0

GCCGACCGGT CCAAATGGCA CATTCCGATA CCGTCGGGGA AAAATTATTT TAGTTTTGGA 180

AAGATCCTCT T CAGAAAT AC CACTATCTTC CTGAAGTTTG ATGGAGAACC TTGTGACCTG 24 0

TCTTTGAATA TAACC TGGTA TCTGAAAAGC GCTGATTGTT ACAATGAAAT CTATAACTTC 300

AAGGCAGAAG AAGTAGAGTT GTATTTGGAA AAACTTAAGG AAAAAAGAGG CTTGTCTGGG 360

AAATATCAAA CATCATCAAA ATTGTTCCAG AACTG CAGTG AACTCTTTAA AACACAGACC 420

TTTTCTGGAG ATTTTATGCA TCGACTGCCT CTTTTAGGAG AAAAACAGGA GCTCGAG 4 77

(2) INFORMATION FOR SEQ ID NO: 46 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:463:

244

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GTTGCACTCC TGTTGTACTC TTTTAGAGGT GGAAAAGAGG TGGATACTGA GATCTAAGAG 60

GAAAGGATAG TCATTCACGT TCTGAGATAT GCGCTCTCTC TATTGTTCTC GAACACAAAG 120

GGATAGTCTC TTTTCTGGAG CTGATGTCCC TGCTTGGAGG TTAGCCCCAA AACATGGCTC 180

TTGTATTGTT CTAAGAGAAA AGGCTTTCAT TTTGGTTCTT CTGATTGGTG TTACCTACTG 240

CCTAATATGT GTTCATTTTT TGACAGAGAG GCAGACTATT GAAAAAGTCT GTGTGAACAG 3 00

AGAGCAGTTC ATTAAGCCCA TTGCTTTCAG TAATGTGGCC TTGACCCCTT CTGCTTCCCC 36 0

CTTCTCCCAT GACGAGCTCG AG 382

(2) INFORMATION FOR SEQ ID NO: 464:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 75 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:464:

GGACCTGCCT CAAGGACATG GGTGGACATA TGGGCGGACT CTCAGGGACA ACCAAAGTGA 60

TGATCACACT GACCGATGTC AATGACAACC CACCAAAGTT TCCGCAGAGC GTATACCAGA 12 0

TGTCTGTGTC AGAAGCAGCC GTCCCTGGGG AGGAAGTAGG AAGAGTGAAA GCTAAAGATC 180

CAGACATTGG AG AAAATGG C TTAGTCACAT ACAATATTGT TGATGGAGAT GGTATGGAAT 240

CATTTGAAAT CACAACGGAC TCTAAAACAC TCGAG 275

(2) INFORMATION FOR SEQ ID NO: 4 65:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 88 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO-.465:

GTTCTAGACC TACCCCGAAC AGCCCCAAAC AGTCAGAGTG GCACAAAATG ACAGTCTCCA 60

AAAACTGCCC CGACCAAGAT CTCAAAATCA AACTTGCTGT CCGAATGGAT AAGCCTCAAA 120

ACATGAAGCA TTCTGGGTAT TTATGGGCCA TCGGTAAGAA TGTCTGGAAG AGATGGAAGA 180

AAAGGTTTTT TGTATTGGTG CAGGTCAGTC AGTACACGTT TGCCATGTGC AGTTATCGGG 24 0

AGAAGAAAGC GGAGCCTCAG GAACTTCTAC AATTGGATGG GTACACTGTG GATTACACCG 3 00

ACCCCCAGCC AGGTTTGGAG GGTGGCCGAG CCTTCTTCAA TGCTGTCAAG GAGGGAGACA 360

CCGTGATATT TGCCAGTGAC GATGAACAAG ACCGCATCCT GTGGGTCCAG GCCATGTATC 420

GGGCCACGGG GCAGTCACAC AAGCCTGTGC CCCCGACCCA AGTCCAGAAA CTCAACGCCA 480

TCCTCGAG • 4 88

(2) INFORMATION FOR SEQ ID NO:466:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 3 00 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:466:

245

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GAATTCGGCC TTCATGGCCT AGCCGCTGCG GTGAGCCTTG AAGCCTAGGG CGCGGGCCCG 6 0

GGTGGAGCCG CCGCAGGTGC AGATCTTGGT GGTAGTAGCA AATATTCAAA CGAGAACTTT 120

GAAGGCCGTC TGAGCTAAAA AATAATGCTG ATTTGGCCTC ATCATATTTA TGAAGGAGGG 180

AGAAATAGAA GCATGTATAA TGTAGAAAAA CATATCTTAT CCTTATGTTT GCATATATTG 24 0

TTGAATAAAT ATAGTTTAAT GAATATGTTT TCTCACCTTT CTTTGCTTGC ACTTCTCGAG 3 00

(2) INFORMATION FOR SEQ ID NO: 467:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 81 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 467:

GT T CTAGAC C TGCCTCGAGA TATGCCGGAA GGTTGCATGG CTGGTCCCAG GGCCAGCACA 60

GGCCCGAGGC CGGGCTGCCT GGTTTTATTT TTATTTAACT TTATTTTCTG TTTTATGAGT 12 0

GTGTGTCCGC CCACCCCCAC CCCCTTCAGT GTTAAGTGGG GAGCCCTGGG GGAGTCTCTC 180

CTGCCTCCCA GCCTCTCCCA AGACCTCCCC CCTCGTCACC AGCCATCCCT CTGGACCAGG 24 0

CAGAGGGCGG ACCGGGTGGG CAGGGGCCTG AGGGTGGCTC GGGCCAGCCC ACCAGCCAAT 300

GGACCCCTCC TCAGGCCGCC AGTGTCGCCC TGCCCCTTTT TAAAACAAAA TGCCCTCGTT 360

TGTAAACCCT TAACGCTCGA G 3 81

(2) INFORMATION FOR SEQ ID NO: 4 68:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 46 8:

GCTGTCCAAT TATACTGACC TGGCCATGAG CACGG TGAAG GAG AC CCAAG CCATTCCATA 6 0

TACTGGTCCC TTTAATTTGC TCTGTTACCA GCTGCAGAAA TTGACAGGTG ATGTGGAAGA 120

ATTAGAAATT CAAGAAAAAC CTGCTCTGAA AGTGTTCAAA AATATTACTG TAATACAAGA 180

ACCAGGCATG GTGGTATTAG AATGGCTGGC AAACCCTTCT AATGATATGT ATGCAGATAC 24 0

AGTAACAACT GTGATATTGG AAGTTCAGTC AAATCCCAAA ATAAGAAAAG GCGCAGAACT 3 00

CGAG 304

(2) INFORMATION FOR SEQ ID NO: 469:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 46 9:

GCGATTGAAT TCTAGACCAC CCCGCACTCC AGCCTGGGCA ACAGAGCAAG ACTCTTTCTT 60
AAAAAAATTA AAAAAAAAAG GAGTACCCAT TGGGATAAAC CTCTTTGGAG GAGAGGACAT 120

246

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AGTACAGAGG TTATACTGCA ACATGGACCC ACCAATAGCC ATGGATAACT TAGTTGGGAT 180

TACCCCTGCC TGCTGTTTAG ATACTTACAT GGACACTAAT TTCTGCCCAT CAACCTCCCT 24 0

CTCTTTCTCC TTCAATGCCC ATCAACCTCC CCCTCTTTCT CCATCAATGC TATGTTGGTT 3 00

TTTTTTATTT GCCATCTTGG CAGGTTTAGG GCAGAGCATG CTCGAG 34 6

(2) INFORMATION FOR SEQ ID NO: 470:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 21 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 70:

GAATTCGGCC TTCATGGCCT AGGATTTTCA GCAAGAATTA AATTATTCTG CATATTGGAC 6 0

AGGGCCTATT TAGAGGCCTG CACATCTGTT TTTATCCATT TGTGTAACGA TACCGTGTGT 120

GAAAGTAGGT TCATGGATCA GATGAGAAAA GTCAATTCTC TAAGATACCT TCCCTTGTGG 18 0

CTGTGGATTC TCACCTTGAT GATTCAGCTT TGTGTGATGG AGGTGTCTGC CAGAGAATTC . 24 0

CTGGCCACCC AGCTCCTCAG CCCTCTGCCC CCACCCCCAA TACACACACC TTTCTCCATT 300

GTACCAGATG CTGGTCTCGA G 321

(2) INFORMATION FOR SEQ ID NO: 471:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 417 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 471:

GAATTCGGCT TCATGGCCTA CTTCATTCAC TGTAAAACCA AT AG CAAACA ACGGAAGAGA 6 0

CGGGCAGAGT TGAAGCAACA AAGAGAGGAG GAGGCAACAT GGCAAGAG C A GGAAGCCCCT 120

CGGAGAGACA CTCCCACCGA AAGTTCTTGC GCAGTGGCCG CCATTGGCAC CCTGGAAGGC 180

AGCCCCCCAG GTATCTCCAC CTCCTTCTTT AGGAAGGTGC TGGGCTGGCC CCTCAGGCTG 240

CCGAGGGACC TGTGTAACTG GATGCAGGGA CTCCTGCAAG CTGCTGGCCT CCATATCAGG 300

GACAATGCTT ACAACTACTG CTACATGTAC GAGCTCCTGA GCCTGGGGCT GCCACTCCTC 360

TGGGCGTTCT CTGAGGTCCT GGCAGCCATG TACAGGGAAT CTGAGGGCTC CCTCGAG 417

(2) INFORMATION FOR SEQ ID NO: 472:

(i) . SEQUENCE CHARACTERISTICS :

(A) LENGTH: 331 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 4 72:

GAATTCGGCC TTCATGGCCT ACAAGAGGCA GCTTATAGAC AACCGCAAGC TCATTGAGAC 60
GCAAATGGAA CGGTTCAAAG TTGTGGAACG AG AG AC CAAA ACCAAAG CTT ACAGCAAAGA 120
GGGCCTGGGC CTGGCCCAGA AGGTAGATCC TGCCCAGAAG GAGAAGGAAG AGGTTGGCCA 1B0

247

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GTGGCTCACG AATACCATCG ACACGCTCAA CATGCAGGTG GACCAGTTTG AGAGTGAAGT 24 0

GGAGTCACTG TCAGTGCAGA CACGCAAGAA GAAGGGCGAC AAGGATCAGA AGCAGGACCG 3 00

GATTGAGGGC TTGAAGCAGC AGCATCTCGA G 331

(2) INFORMATION FOR SEQ ID NO: 473:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 260 base pairs

(B) TYPE', nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO:473:

GAATTCGGCC TTCATGGCCT AGAGGTGCTT C AG TGGTAC A ATCAGTTAGC ACACAGTACG 60

TATACAGCAG TATGTGTGTG AGAAATTATT TTAAATATAA GAATTATCAA AAATTATAAG 12 0

AAGACCATCC CTTTAACTGA ATAGTTTCAC CAAAAATCAG AAAAATATGT AAGTGATACA 180

TTTTGTTTCT TGGATATAGC AATGTACCAC CTTGCATAAA TGAGACTATT AAAATGATCA 240

CCTGAGGTCA GAAGTTCGAG 260

(2) INFORMATION FOR SEQ ID NO: 4 74:

(i) SEQUENCE CHARACTERISTICS:

(A> LENGTH: 511 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:474:

GAATTCGGCC TTCATGGCCT ACAAAGATTT GAGGAAAAGA GGTTCAAATT GGACCACTCA 60

GTGAGTAGCA CCAATGGCCA CAGGTGGCAG ATATTTCAAG ATTGGTTGGG AACTGACCAA 120

GATAACCTTG ATTTGGCCAA TG TCAATCTT ATGTTGGAGT TACTAGTGCA GAAGAAGAAA 18 0

CAACTGGAAG CAGAATCACA TGCAGCCCAA CTACAGATTC TTATGGAATT CCTCAAGGTT 24 0

GCAAGAAGAA ATAAGAGAGA GCAACTGGAA CAGATCCAGA AGGAG CTAAG TGTTTTGGAA 300

GAGGATATTA AGAGAGTGGA AGAAATGAGT GG CTTATACT CTCCTGTCAG TGAGGATAGC 3 60

ACAGTGCCTC AATTTGAAGC TCCTTCTCCA TCACACAGTA GTATTATTGA TTCCACAGAA 42 0

TACAGCCAAC CTCCAGGTTT CAGTGGCAGT TCTCAGACAA AGAAACAGCC TTGGTATAAT 48 0

AGCACGTTAG CATCAAGACT GAAAACTCGA G 511

(2) INFORMATION FOR SEQ ID NO: 4 75:

( i ) • SEQUENCE CHARACTERISTICS :

(A) LENGTH: G10 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 475:

GAATTCGGCC TTCATGGCCT AGTCACAGCT GTCTATTTTT GTCACTGTCG GAACATTGTT 6 0

CATCGTGATT TAAAAGCTGA AAATTTACTT CTGGATGCCA ATCTGAATAT CAAAATAGCA 120

GATTTTGGTT TCAGTAACCT CTTCACTCCT GGGCAGCTGC TGAAGACCTG GTGTGGCAGC 180

248

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CCTCCCTATG CTGCACCTGA ACTCTTTGAA GGAAAAGAAT ATGATGGGCC CAAAGTGGAC 24 0

ATCTGGAGCC TTGGAGTTGT CCTCTACGTG CTTGTGTGCG GTGCCCTGCC ATTTGATGGA 300

AGCACACTGC AGAATCTGCG GGCCCGCGTG CTGAGTGGAA AGTT C CGCAT CCCATTTTTT 3 60

ATGTCCACAG AATGTG AG CA TTTGATCCGC CATATGTTGG TGTTAGATCC CAATAAGCGC 420

CTCTCCATGG AGCAGATCTG CAAGCACAAG TGGATGAAGC TAGGGGACGC CGATCCCAAC 4 80

TTTGACAGGT TAATAGCTGA ATGCCAACAA CTAAAGGAAG AAAGACAGGT GGACCCCCTG 54 0

AATGAGGATG TCCTCTTGGC CATGGAGGAC ATGGGACTGG ACAAAGAACA GACACAGAAG 600

GCGGCTCGAG 610

(2) INFORMATION FOR SEQ ID NO: 47 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 476:

GGAGATTGGC CACCTCCAAG ATATGGTAAG GAAAAGTGAA CAAGGTCTTG ■ GCTCTGCAGA 60

AGGACTTATT GCTAGTCTTC AGGACTCCCA GGAAAGGCTT CAGAATGAGC TTGACTTGAC 120

TAAAGACAGC CTAAAGGAGA CCAAGGATGC TCTATTAAAT GTGGAGGGTG AGCTAGAACA 180

AGAAAGGCAA CAGCATGAAG AAACAATTGC TGCCATGAAA GAAGAAGAGA AGCTCAAAGT 240

GGACAAAATG GCCCATGACT TAGAAATTAA GTGGACTGAA AAT CTTAGAC AAGAGTGTTC 300

TAAACTT CGT GAAGAGTTAA GGCTTCAACA TGAAGAGGAT AAGAAGTCAG CAATGTCTCA 3 60

ACTTTTGCAG TTGAAAGATC GAGAGAAAAA TGCAG CAGAG AAACTCGAG 409

(2) INFORMATION FOR SEQ ID NO: 477:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 272 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:477:

GTATGCCTGT TCCAGACCAG CCTTCATCAG CCTCAGAGAA GACGAGTTCC CTGAGCCCCG 60

GCTTAAACAC CTCCAACGGG GATGGCTCTG AAACAGAAAC CACCTCTGCC ATCCTCGCCT 120

CAGTCAAAGA ACAGGAATTA CAGTTTGAAA GGCTGACCCG AGAGCTGGAG GCTGAACGGC 180

AGATCGTAGC CAGCCAGCTG GAG CGATG CA AGCTCGGATC CGAGACTGGC AGCATGAG CA 240

GCATGAGTTC AG CAG AAG AG CGGATACTCG AG 272

(2) INFORMATION FOR SEQ ID NO: 47 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 284 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:478:

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GAATTCGGCC TTCATGGCCT ATGCGTGGGG GTGGGGGGGC AGGCTAGAAA GGAGCCCTCC 6 0

CTCCTCGGGG TGTCTAGGGT GTGCTGGCCA CTGGAAGATT GGAGTCGCTG ACCCAGTGCT 12 0

GACCCTGACC CTTGGCTGGG TCCACTCTGC AGACTCCACC TGAGGAGACC CACCCAGGGT 18 0

GAAGCTCGGT GCCCAGGCCT GAACTGAGCC CGGCCGGGTG CAAGGGCTGA GGTGTGAGGT 24 0

CGGCCCAGGC CTCTTCCCAG GCCTGAGGGT GGCTACAGCT CGAG 2 84

(2) INFORMATION FOR SEQ ID NO: 4 79:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 52 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
(D> TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 79:

GAATTCGGCC TTCATGGCCT ACTAAATTTT CCAAAACGTT GATTTGCATA ATACAGTGGT 60

ATGTGCAATG GATAAATTGC CGTTATTTCA AAAATTAAAA TTCTCATTTT CTTTCTTTTT 120

TTTCCCCCCT GCTCCACACT TCAAAACTCC CGTTAGATCA GCATTCTACT ACAAGAGTGA 180

AAGGAAAACC CTAACAGATC TGTCCTAGTG ATTTTACCTT TGTTCTAGAA GGCGCTCCTT 24 0

TCAGGGTTGT GGTATTCTTA GGTTAG CGGA GCTTTTTCCT CTTTTCCCCA CCCATCTCCC 3 00

CAATATTGCC CATTATTAAT TAACCTCTTT CTTTGGTTGG AACGACCTCG AG 3 52

(2) INFORMATION FOR SEQ ID NO: 4 80:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 3 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 80:

GAATTCGGCC TTCATGGCCT ATTAAAAGAA TGTTCTTTCA TTAAAAGACC AAAAAGAAGT 6 0

TAAAACTTAA ATTGGGTGAT TTGTGGGCAG CTAAATGCAG CTTTGTTAAT AG CTGAGTGA 12 0

ACTTTCAATT ATGAAATCTG TGGAGCTTGA CAAAATCACA AAAGGAAAAT TACTGGGGCA 18 0

AAATTAGACC TCAAGTCTGC CTCTACTGTG TCTCACATCA CCATGTAGAA GAATGGGCGT 24 0

ACAGTATATA CCGTGTTCTC GAG 263

(2) INFORMATION FOR SEQ ID NO: 481:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 37 9 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 81:

GGAGCAGGAA GAAATGCAAG AGGAGATGGA GAAGCTGCGA GAGGAAAACG AGACTCTCAA 60

GAACGAGATC GATGAGCTGA GAACCGAGAT GGACGAGATG AGGGACACTT TCTTCGAGGA 120

GGATGCCTGT CAACTGCAGG AAATGCGCCA CGAGTTGGAG AGAGCCAACA AAAACTGCCG 180

GATCCTGCAG TACCGCCTCC GCAAAGCCGA GCGCAAAAGG CTCCGCTACG CCCAGACCGG 24 0

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GGAAATCGAC GGGGAGCTGT TGCGCAGCCT GGAGCAGGAC CTCAAGGTTG CAAAGGATGT 300
ATCTGTGAGA CTTCACCATG AATTAGAAAA TGTGGAAGAA AAGAGAACAA CAACAGAAGA 360
TGAAAACGAG AATCTCGAG 379

(2) INFORMATION FOR SEQ ID NO: 4 82;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 01 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:482:

GAATTCGGCC TTCATGCTTT CTAGGCAAGA GGTCATCAGA AGATTGAGAG AAAGAGGAGA 60

ACCAATCAGA CTATTTGGAG AGACTGATTA TGATGCTTTT CAACGTTTAA GGAAAATAGA 120

GATCCTCACA CCAGAAGTTA ACAAGGGATT GAGGAATGAT TTGAAAGCAG CCTTGGATAA 180

GATTGATCAG CAGTACCTCA ATGAAATCGT CGGCGGTCAG GAGCCTGGAG AGGAAGACAC 240

ACAGAATGAT CTGAAAGTTC ATGAGGAAAA CACCACAATT GAAGAGTCAG AGGCCCTCGA 3 00

G 301

(2) INFORMATION FOR SEQ ID NO:483:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 83:

TGGTCTCCAG AAATGCTTTG GGTTCATCTT TCATTGCTGC AAGGAACTTC CATGCCTCTA 60
ACACTCATCT TCAAAAGACT GGGACTGCTG AGATGTCCTC TATTCTTGAA GAGCGTATTC 120
TTGGAGCTGA TACCTCTGTT GATCTTGAAG AAACTGGGCT ATCTCGAG 16 8

(2) INFORMATION FOR SEQ ID NO: 484:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 452 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:484:

GCAAGCTCTC CATGGAAACC CCTGCCAAAA CAGAAGAGAT AAAACTGGAA AAGGCTGAGA 60

CAGAGTCCTG CCCAGGCCAA GAGGAGCCTA AATTGGAGGA ACAGAATGGT AGTAAGGTAG 12 0

AAGGAAACGC TGTAGCCTGT CCTGTCTCCT CAG CACAGAG TCCTCCCCAT TCTGCTGGGG 180

CCCCTGCTGC CAAAGGAGAC TCAGGGAATG AACTTCTGAA ACACTTGTTG AAAAATAAAA 24 0

AGTCATCTTC TCTTTTGAAT CAAAAACCTG AGGGCAGTAT TTGTTCAGAA GATGACTGTA 300

CAAAGGATAA TAAACTAGTT GAGAAGCAGA ACCCAGCTGA AGGACTGCAA ACTTTGGGGG 360

CTCAAATGCA AGGTGGTTTT GGATGTGGCA ACCAGTTGCC AAAAACAGAT GGAGGAAGTG 420

AAACCAAGAA ACAGCGAAGC AAAGGACTCG AG 452

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(2) INFORMATION FOR SEQ ID NO: 4 85:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 52 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 485:

GTTTGTAAAT CACCTGATGA TGGTGATATA GCTGTGGCCA ACGAAATGTC AAGGGAAGTC 6 0

TGCTGGGGAA GGTAGACGTA GGATAGGAGT ATGGGAAAAA ATTATTCACT CAAAAGCATG 120

ATGCACAGAG GAGCTATGAT CTTTTCTTGT TTTCCTCACT GGATGTTGTC ATGTCTGTAT 180

GTACTTCCTG GAACTGTGGC ACCATCTTAC AAC C ATGAAA GGAGCTCACA TGAAATCATG 24 0

TTGAACATAG CAGAGCGGGA AGATGGAAGG AAT CCGAG AT CTATGTTTGA TGTTAAGCGA 3 00

TGATGTTAAA AACTTAAAAA ACTCCAGAAC TCTCTTACCC CTGGTGCTCG AG 352

(2) INFORMATION FOR SEQ ID NO: 4 86:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 420 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 486:

GAATTCGGCC TTCATGGCCT ACTCAGCTGG AAGCTTTACT CCCTCCTCGA CAGAAAGTGA 6 0

GGATTACAGA TGACATGGAT CAGGTGGAGC TGAAGGAGTT TTGTCCCAAT GAGCAGAACT 120

GGCGTCAGCA CAGGGAGGCC TACGAGGAGG ACGAAGACGG GCCCCAGGCT GGAGTGCAGT 18 0

GCCAGACGGC ATGACGTGGT GCGGGGCAGC GTGGCCCCAC CGGACTAGCA CATGATGAAT 24 0

GTAAAGTTGG CACAATGAAA ATGACATCGC TTTAATGGCC TTGTGTTTGG GATGTCCTGT 300

GTATGTGTTC AGCATTCTTA ATTGCTGAGT GTCTTTTTGG CTTTTCTTTT GGTTGTAACT 360

TAAGTTATAG CTTAATTTAT ATTTAAATGT TTTAAGTATA AATCACCTCT AGGCCTCGAG 420

(2) INFORMATION FOR SEQ ID NO: 4 87:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 318 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:487:

GGAGTGTCAA GAATAACCGC TCAGGTTGAG TG TAAAAATA TTTTATGGTC CCATCAGCAT 60

CAACCTGCCT TAATGCTTCT TTGGTTGTCT CTTCAGCTAG TTCTTATTTT ACAGCACATG 120

ATATATGAAG TGATTTCACA CCATGCCCAA GATACGGGCC ACCCACCAGC TACATGGCAT 180

GATGACTCTG CAGG CCGAAC GGCAGCCTTG ATAATTATAA GGCCATGGGT AATAGCCCCC 24 0

CAGGGGTTCA CAGATCTTCT GGCAGTGGGT GTAGCTCCGC CTACATTCTA TACAACAGAT 300

TCCTTCGCCT GCCTCGAG 318

(2) INFORMATION FOR SEQ ID NO: 488:

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 487 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

tii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:488:

GAATTCGGCC TTCATGGCCT AGGTGTTTGC TTTAAGGAGG AATAGAAAAA TCAGGTGGTC 60

ACTACTACAA GGGAAAGGGG AATGTGGTTT CAAAAAGGG T TTTGCCTTAT TTATTTTTAT 120

AGTAGATACT TATTAATCAA ACATTTAAGA GCAACTCAGT AAGTATTTGT CCAGAATGAA 180

CTGTTCTCAA GACTAGGTTT ACTGCTTGAC ATTAGAGGTT AAGGTGTTGC AATTCTGAGT 24 0

CTTGTTTTTT ATTACTACCA ACCCCCACCC CCGCCGATAT TACTTCATCT CCCTCCAAGG 3 00

TCACTGAAGT TTTTCATAAC TATTTTAACA GATATTGCAA TAAATGTACA GTAATTTAAC 360

TATCCTTCTT GCTGGGCATG TCAAAGTGTT TTCTATTATT ACAGATAATG CTGCAATGAA 420

TCTTTATTTA TATAATACAC TTTTATCCAG TTGTCATTTT TTCTTTGTCT TATATTCTCA 4 80

CATGGAA 4 87

(2) INFORMATION FOR SEQ ID NO ; 48 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 149 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(P) TOPOLOGY: linear

<ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 489:

GCGATTGAAT TCTAGACCTG CCTCGAGACA AAAACTGTGA ATAGTGAGTG ATTTAAAAAA 60
AAAAAATAAA CTGAAAGGAA AATTGTTGAA TGTTTGAATC TTGCCTAGTC CCCTCACCCC 120
CAAGGCTGGC TTCTAGAGTT AAGCTCGAG 14 9

(2) INFORMATION FOR SEQ ID NO: 4 90:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 59 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 90;

GCAAATTTTG GAAGATTTAG ACCATTATTT CTCAAAATAT TTCTTACCTG CTCTCTCCTC 60

TTTCTCCCAC TCCTCCCCAT CACCTTCTGG CACTTCCATT GTTCATATAT TGATATGCTT 120

AATGATGTTT CTGAAGATTT ATTCATTTTT CCTTTATTCC TTTTTATTCT GTTCCTCAGC 180

CCAGATCATT TCAATGCACA TATC CTCAAG TTTGCTGATT CTTTCATTTC CTGCTCAGAT 24 0

CTGCTGCTGG CCCCTCGAG 259

(2> INFORMATION FOR SEQ ID NO: 491:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 320 base pairs

(B) TYPE: nucleic acid

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(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 491:

GAATTCGGCC TTCATGGCCT ACAAATGTTT AAT CAGAGAC TCATATTCAC CTTTAAGTAA 60

AAAACATACT TCTTTCCCCC TAATAGTCAC AGCATTCTGC AG AG CTAAAG AAGGAGACCA 120

GGAGTCTGTG GGAGCAAAGA TCATTTTGTG AAGCTAGAGG TCCAATTTAA AAGCAGTTGC 180

TGCTACAAAT TAAAACATAT TTGCATTCTG CCTAAAATAG TTGTCTCTTT GAACGTTGGG 240

TGCCTTTTTT AGGTTGCTTT GTGAATAATA TGCACAAAAT GAAAATGTTA AAAAAAACAT 300

GTAGCCTGCT AACCCTCGAG 320

(2) INFORMATION FOR SEQ ID NO:492:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 224 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 92:

GAATTCTAGA CCTGCCTCCA GCCACTTCAA ACCTTTGGTG ACCAAAGTGG GGTAAAAACA 60

AGCACCTGCG TGCGTTGTGG TTATT CTATG CTCTCCAATA TATATAAATT TTAAGAAGTT 12 0

TTTCTTGAGG TGGTCAGTTC TTAAACCAAG AAAGTGGTAG TAGTTGATTT TAATTAGTGT 160

AAAGTTG TCT TCGTAACTTC CGTGTTGGTT GGAAATAGCT CGAG 2 24

(2) INFORMATION FOR SEQ ID NO: 493:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 93:

GAATTGCCTT CATGGCCTAC CGAATCAGAC AGAAGAAAGC CCAGGGCTCC ACTTCTTCTA 6 0

CAAGGTTGCA TGAGCCCGAG AAGAATGCCA GAGAAATAAC ACAGGACACA AATGATATCA 12 0

CATATGCAGA CCTGAACCTG CCCAAGGGGA AGAAGCCTGC TCCCCAGGCT GCGGAGCCCA 180

ACAACCACAC GGAGTATGCC AG CATTC AGA CCAGCCCGCA GCCCGCGTCG GAGGACACCC 24 0

TCACCTATGC TGACCTGGAC ATGGTCCACC TCAACCGGAC CCCCAAGCAG CCGGCCCCCA 3 00

AGCCTGAGCC GTCCCTCGAG 320

(2) INFORMATION FOR SEQ ID NO: 494:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 504 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) topology : linear

(ii) MOLECULE TYPE: CDNA

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(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:494:

GAATTCGGCC TTCATGGCCT AGGTAGCTCT ATGGTTTTCC TCGCGTTCTT GAGTCGGGAA 6 0

ATGGCCGCTG TGTGGTTGCA ACGGAGATAA ATTCCCGGAA CCGCGATTCG GCGTGTCAGG 120

AATTCGAATT TAG AG TTTAA TTTCTCAGAG CATTCTCTCC AGGAAGAATT TTTACAGTAT 180

CTCAAAGACT TCACTTGACT TCTTGATCCT GCATAAAACC AAGGAGAAAA GAAATGGGTC 240

GCTCCAATTC TAGATCACAT TCTTCAAGGT CAAAG TCTAG ATCACAGTCT AGTTCTCGAT 3 00

CAAGATCAAG ATCTCATTCT AGAAAGAAGC GATACAGTTC TAGGTCTCGT TCCAGAACAT 36 0

ATTCAAGGTC TCGTAGTAGA GATCGTATGT ATTCTAGAGA TTATCGTCGC GATTACAGAA 420

ATAATAGAGG AATGAGACGA CCTTATGGGT ACAGAGGAAG GGGTAGAGGG TATTATCAAG 4 BO

GAGGAGGAGG TAGAAACCCT CGAG 504

(2) INFORMATION FOR SEQ ID NO: 495:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 190 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 495:

GAATTCGGCC TTCATGGCCT ACCAACTTAG TCATTTGAAG CCCAAGAGTC TAATTTTATA 6 0

TGCCCTGCCA ATGTC CTCAT CTATTGCAGA ATGNATAATT ATCTATTTGT TTTGGACTAT 120

ATGTTACAAA AATTTAAAAC ATAAGATCCT CTCTCTATAT TTCATTATTG GTGAACCCAC 180

ATTG CTCGAG 190

(2) INFORMATION FOR SEQ ID NO:496:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 05 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:496:

GAATTCGGCC TTCATGGCCT AGGTAAGAAA ATCGTCAATG AATTGTGGCA TGACCAGGTG 60

GAGAGTAAGT GTCATAAAGA GGGATAGTGG ATAGTATAAT GTCAGGCACC TCAAAGGAAC 12 0

TGGGCAGGGA GTTAGGGAGT AAAAAGGGCG GTGGTCTGGA AG C AG AAAGG AGGAGCAGTG 180

GTCCAGTAGG GGCTGCAGAG CTGCAAGGCT TTGCCTCAAT CCTGT CAAAG GCAACTTCAA 24 0

GCTTTCCAGG AGCCATACTC CTTCATTTGT TCATTACTTT CTAGATTAGG AAATCACCAC 3 00

TCGAG 3 05

(2) INFORMATION FOR SEQ ID NO: 497:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 97:

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GAATTCGGCC TTCATGGCCT AGGTGGACCA ATGTACAGCA CTCAGGTTCA TGGCCAACTG 6 0

GGTGGACTAT TTCAGTACTC TACAGGTGCC TCAGTGGAGG GAGAGCCCAT TGTCCAGGTG 120

CTTCCTGGGA CAATACCAGA GCGCTCTGGG AAAAGGGCTG CTTGCAGGCA CGAGGGCTCA 180

CAATGAGCCA TGGTGGGCCA CCGCCACGGC CCATGCAGCC TAATAGCAAG CCAAGGCAGG 24 0

AAGCTGTGAG AGCTGCTCAA CAGTGCCCCC TAGGGACTGG TTACTTCCTG ACCCTAACCT 3 00

CCGGAAATCT G CTGTCAAAG GCAGATTTCT CGAG 3 34

(2) INFORMATION FOR SEQ ID NO: 4 98:

ii) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 160 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4 98:

GAATTAGGGG CTTTTTCATC CTTAGGAGAC CTGAGTCCTC AAGAAAACCC TTTTCTGGAA 60
GTATCTGCTC CTTCAGAACA TTTTATAGAA AAGAATAATA CAAAACACAC AACTG CAAG A 120
AATGCCTTTG AAGAAAATGA TTTTATGGAA AACACTCGAG 16 0

(2) INFORMATION FOR SEQ ID NO: 4 99:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 4 99:

GAATTCGGCC TTCATGGCCT ACTCGATCTC CTGACCTCGT GGTCCACCCG CCTCGGCCTC 6 0

CCAAAGTTCT GGGATTACAG ACGTGAGCCA CCGCGCCCGG CCTTGTCCTG GATTTTT TAA 120

CCAAGCACTA TTATTTATAG TTGCGTTAAA ATAAATAGGG ATGGGTTTGA TAAGTCACCA 180

CTTGGTGCTT TAAATTCTGC CATCATCTTT TCTAGGAGTG TAAGATATAG AGATACACAT 24 0

AAGCAGAAAA TTTTTTTTAA CATGAGGATA CTCGAG 276

(2) INFORMATION FOR SEQ ID NO: 500:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 256 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:500:

GAATTCGGCC TTCTGGCCTA GACCTGCCTC TGATATGTAC TTGGTTTTTA AAAACCCATT 60

TTGTTCTCTC TTGTTTCCTC TCTATTTCAG CCTAGTATCA GAAGGCCAGG CGAGACTGCA 120

ACACTGCTCA TCACCCCGCG GCGTGATCCC TGCTCTTAGG TGCTGGGCAG AGGGGAAGGG 180

TGGTCAGGGT GAGGATGGTG AGGGAGGGCT GGTGAGGGGC TCAGAGGAAT ACTTGGAACA 24 0

ACAGCAGTGT CTCGAG 256

256

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(2) INFORMATION FOR SEQ ID NO: 501:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 5 base pairs

(B ) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D> TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 501:

GAATTCGGCC TTCATGGCCT AGTGGTTTTG TTGTTGTTGT CGGAGACAGG GCCTCGCTTG 6 0

GTCTCCCAGG CTAGAGTGCA GTGG CATG AT CACGACTCAC TGCAGTCTCG ACCTTCTGGG 12 0

CTCAAGTGAT CCTCCTGTGT CAGCCTCCCA CACAGCTGGG ACTACAGGCA CATGCCACCA 180

CATCCAGCTA ATTTAAAAAA CATTTTTTTT GTAGAAATAG GGTCTTACCA TGTTGCCCAG 24 0

GCTAGTCTCA AATTCCGGGG CTCAAGCAAT CCTCCCACCT CACCTTCCCA AAGTG CTGGG 3 00

ATTACAGGCA TGAGTCACCA TACTTGGCCC GAGTGAGCCA AGATTG C AC C ACTGCACTCC 360

AGCCTGGGCT ACAGAGCAAG ACACTATCTT AGATCCNNAA AGGAAAAAAA AAAAAGAAGG 420

AGAAAGAACC AGAGAAACAT AAGGAAGAGT GAGAGGAAGA AAGAAAGATG CAATTTGGGA 4 80

AGAAATGAAA AAGAAATGAA TAAAGAATAA AATAATGTAA CGGT CAATAA ATAGGACTTG 54 0

TGAATGGAGG CCTTTAGGCC AAAGG CTATG AT TAATTT CA AGCTATGTTA CTGAAGTCCA 600

TAAACAAAGG ACTCAGATCT AAATGGGTAC TCGAG 63 5

(2) INFORMATION FOR SEQ ID NO: 502:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 52 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: double
<D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 502:

(2) INFORMATION FOR SEQ ID NO:503:

(i) ' SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 86 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:503:

GAATTCGGCC TTCATGGCCT ACAAAATTGT CTTGACATAA GTAATTTGGG TATG CTGTAT 60
AAAGGCTTCT AAGAATTAAG AAACATGGCC CGGGTTGCAA ATTTTAATGC ATGACTACCT 120

GAATTCGGCC TTCATGGCCT ACC CGTAGAA ATCCCCCTTT CTCTAATAG C GAGGCTCTAA

CCACACAGCC TACAATGCTG CGTCTCCCAT CTTAACTCTT TGCCTTTGCC ACCAACTGGC

CCTCTTCTTA CTTGATGAGT GTAACAAGAA AGGAGAGTCT TGCAGTGATT AAGGTCTCTC

TTTGGACTCT CCCCTCTTAT GTACCTCTTT TAGTCATTTT GCTTCATAGC TGGTTCCTGC

TAGAAATGGG AAATGC CTAA GAAGATGACT TCCCAACTGC AAGTCACAAA GGAATGGAGG

CTCTAATTGA ATTTTCAAGC ATCTCCTGAG GATCAGAAAG TAATTTCTTC TCAAAGGGTA

CTTCCACTGA TGGAAACAAA GTGGAAGGAA AGATG CTCAG GTACAGAGAA GGAATGTCTT

TGGTCCTCTT GCCATCTATA GGGGCGCTCG AG

60
120
180
240
300
360
420
452

257

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TTTTTTCTAT AG AATATAG C TTTTGTCAGA TTCTCAGCAG TGGCTCTGAT CCAGAAAACA
TTAAGAACCA CTGGTCATGA GTGGTGATTT TCAGCTTTTT TGGTCTTAAC CCACTTAGGT
GGGACAGAAG CTCCTTATCT CACCTATACC ATCCAGCATC CTCGAG

180
240
286

(2) INFORMATION FOR SEQ ID NO:504:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 424 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:504:

GAATTCAGCC TTCATGGCCT AGAGGGGTTT AGGATTCAAA G CAAAGGGG A GACAGCTACT 60

AAGTAAACTA CAAAATAATT GCTAAACTGA AAATTGTATA AAGTGTACTG GACAGATGAT 120

GTTCCTAATT CTTATCCATG AAATATTTTC TGCCTTCTTA GAGGAAATAG CACCTGACAC 180

AACACTAGCC ACATTGTAGG TGATCAATCA GCACATGTCT AAATAAATTA ATTAAAAAAG 240

AATCAATTAG AAATTCCACT GAAAATTCTT CTTAAATATA ACCAACTTCA TTATGACAAG 300

CTATGAATAT AGAGCTTACA TACATGTTAT ATATCAATAT GTGAGTAGAT AAAGAATGAA 36 0

TGCCTTAAAT TGTTGGATTT TTTATTGTTT TTGTTCTTGT TTTGGAGATG GGGTCTCACT 420

CGAG 4 24

(2) INFORMATION FOR SEQ ID NO; 505:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 204 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 505:

GAATTACTCA GTTTTCAGGT TCTTCCTAGC TCGGGGCTTT TAAATTTTGA AATCTAAACA 6 0

TTCTTTCCCA CCATCCTTTT TGACTGTTGA CCTTGGTTTT CTCTTCTAAG TTTCTGTCCC 12 0

TCTGCTTCCT TACTTTTTTT CCTTTTTGAA TTCTATCTTT ATCTGTCTTT TGTTCACTTT 180

TTAATGCTAT ATATGG AT CT CGAG 204

(2) INFORMATION FOR SEQ ID NO: 506:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 218 base pairs

(B) TYPE i nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 506:

GAATTCGGCC TTCATGGCCT ATAGGCCATG AAGGCCGAGA TGTACAGTAA TAAGTATG CA 6 0

CAGAAATGTT AGATTATTTT TGAAGATGTG GAGAAACTAC TGTTATTTTT GCTTATATTC 120

TTCTCTAAAA ATTCACTAAA TGAATAACAG TTATTGGTTT TGCTATTCAA GATAATTATA 180

AAAATATCTA TTATAGCTAA TCTTCACATG AACTCGAG 218

258

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(2) INFORMATION FOR SEQ ID NO: 50 7:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 52 base pairs

(B) TYPE: nucleic acid

(C) STRAND EDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 507:

GAAGTTTAAC ATTTCAACTG TTGGTAAAAT CTCCCTGGTG CCACCTTGTC GCACCCCCCT 60

GTTATGAGGC ACAGTTAGTG GGTTTATGAG AGGTTTGTTC AGTGAAGCTC CTGCCACTGT 12 0

AGAC CTAAAT GTTTCTCTCC CTGTTGAAGT GACCTGCCTT CCTCTTTAGT ACCTAACACA 180

GTTGGCAAAG AGCATGGCTA ACTCAAACCC TTTTCTTTGG GGGCAGGCTT CCCTTTCTCT 240

CTGGCAGGTA TATTAAAAAA TTACAAAATA GTAAATTTGC CAAATTTTTC TTGGTGTGTA 3 00

G CAAGGCATA AAGACTGAAA AATATCTTAT GAATTAGTTC ACTTCCCTCG AG 3 52

(2) INFORMATION FOR SEQ ID NO:50B:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 283 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5 08:

GAATTCGGCC TTCATGGCCT AAAATGATAC AGTGTGCAGA ACTGGACCCA GTAGGGAATG 60

ATAAAATGTA CAGATGTGCA GAACAGGACT TGGTAGGACT CAGCAGAGAA AACAGGAGGA 120

GAGATGAAAA TGATATGGTG TGCAGAACTG GACTCAGTAA GGTGCGGAAA GGGGAAGGAT 180

TCTGACAGAA TCCAGCACAA AAACAGAGAG GGTG CAGAAA AAGAGATTTG GTCACTTAGA 24 0

CGTGTGGAGT TGGAGG AG C C TGTGGGAAAT CCAGGATCTC GAG 283

(2) INFORMATION FOR SEQ ID NO: 509:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 5 base pairs

<B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 509:

GAATTCGGCC TCATGGCCTA CTCTCCTTTC TTAACTTGTG TACTTGGGGG CACTTTTGAT 6 0

TTTGGTCCCA CATCATTGAG GAAGCTGGCC CAGAGTTCGT CCTCCTTCTT TTTCCTGGCA 120

TCCTCTGATC CAATGCCTTT TTCCTGCTCT GCAGCGTCAT CTTCCTCCTC ACTACTGCTT 180

CCCTCAGATT CTGAATTGGC ATCCTCCTCT TCCTCTTCTT CTAATGAGAG GCCACCTTGT 24 0

CTTCTCTTCC TGGCTGGAAT GCTCTGGGCC TTTCTTTTTT TCCCTTGGGT TTTCTGTGTC 300

TGCTCTTCAC CATTAGG CCA TGAAG 325

(2) INFORMATION FOR SEQ ID NO: 510:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH; 281 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

Ui) SEQUENCE DESCRIPTION : SEQ ID NO: 510:

GAATTCGGCC TTCATGGCCT AGACAGGAGG TCATTGGGGA TTTTAGAAGG TTACACTGGA 60

TACATTTCCA TTAAGCTTCA CGATATCCCA CAGGTCCATT CTGTGTGAAA TGGTCTAAAA 120

ATTTCCTGTT CTCATGCTTC ATTTTTTTCT TTTAGTAATA TTCCTAATTG TGTAAAATAG 180

TATTTCTTTT CATTTATCTT AATTATGTTA TATTAAGATA TCATGTGTAT GCTTAAATTA 240

TACTTTTGGG C TTCAAATG A GTGACCCCAC TCAGACTCGA G 2 81

(2) INFORMATION FOR SEQ ID NO:511:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 511:

GAATTCGGCC TTCATGGCCT AATTCCCTTG ACTCAAGACA GCTAACTTCA TTTTCAGAAC 60

TGTTTTAAAC CTTTGTGTGC TGGTTTATAA AATAATGTGT GTAATCCTTG TTGCTTTCCT 120

GATACCAGAC TGTTTCCCGT GGTTGGTTAG AATATATTTT GTTTTGATGT TTATATTGGC 180

ATGTTTAGAT GTCAGGTTTA GTCTTCTGAA GATGAAGTTC AGCCATTTTG TAT CAAACAG 240

CACGCTCGAG 250

(2) INFORMATION FOR SEQ ID NO; 512:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 233 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 512:

GAATTCGGCC . TTCATGGCCT AATTGATTCT AATCTTTCCC AAACAGTGCT GTGGCAATGT 6 0

ATGAAAGTAA TAAAAATAAT CCTTTTTCTG TTAAAAAAAA AATTGCTGTT ACTTGCTGTT 12 0

TTGTTATGCT TTTGCTGGAG ATTTTCCCAC CCATCTTAAA GCAGCAACTT CAGGATGGGG 180

GAATCAAGCA AAACCATGGT GAAGAGATTC ATTTAAAGAG GACAAGTCTC GAG 233

(2) INFORMATION FOR SEQ ID NO: 513:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 58 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

260

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(xi) SEQUENCE DESCRIPTION: SEQ .ID NO:513:

GAATTCGGCC TTCATGGCCT AGTCACCTTT TGTGGGAACT TCTCTCAGCG AAGCGGAGCA 60

TGCGAATTTG ACATCATGAT TGTCTGAAAA TTGGTAAGCC ACTATCCCAG AAAGAGCTCC 120

CTATGCCCAG GGCTTGCAAT GCTAAGAGAA GGAGGCAGGA GAGAGACAGG GAG CG AC ACT 180

ACATTTGGTG GGGTGAGGAT ATGAGGTTCC TTGGACATCA TGGCCTCCAG TGAATATGTG 24 0

GGTGATGGCT TGGAACTTAA GCTTTTTTGC TAGTGCCCCA CAAAAG AG TA CCCTCCACAA 3 00

CCCATCTGTG GACCACAGCA GTGCCTCTCA ACAAACATGT GCCCCAAGGA GTCTCGAG 3 58

(2) INFORMATION FOR SEQ ID NO:514:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 337 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 514:

GAATTCGGCC TTCATGGCCT AGAATAGAGG AAAATAG CCG CCTGGTGGCT AGACAATTTA 60

GGTGTAGAAA ACACATTTAT ATGGTTCTTT GAATGTAACA GTG GTAAAG A ATATAGGTTT 120

AGTTGTTGCT GCTAAGTAGG G GGAAATG AC ATTTTTATCT GGTATGTTTG AGAATAAAGT 180

AAATTTCAAA AT TTG AG ATG AT CGAAGTTT TTATTTATAA ACTTAAGTAT TATTATAATA 24 0

TGTTACATAT TTTATTCTTT AAAAATTGTA ATTCAGAGAG TGTAACAAAA TGTACTTCCT 300

CACTTTCTTG CTTTTTGTTT CCCAGAAGTA ACTCGAG 3 37

(2) INFORMATION FOR SEQ ID NO: 515:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 66 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 515:

GAAAAGATGG AAGAAAACCA CCATAG CACT G CAGAAGAAC TACAGG CTAC TCTACAAGAA 6 0

TTATCAGACC AGCAACAAAT GGTACAGGAA TTGACAG CTG AAAATGAGAA GCTGGTGGAT 120

GAAAAGACGA TTTTAGAGAC ATCCTTTCAT C AG CATCGAG AGAGGGCAGA GCAG CTAAGT 180

CAAGAAAATG AGAAGCTGAT GAATCTTTTA CAAGAGCGAG TAAAGAATGA AGAGCCCACC 240

ACTCAGGAAG GAAAAATTAT TGAACTGGAG CAGAAGTGCA CAGGTATTCT TGAACAGGGC 3 00

CGCTTTGAAA GAGAGAAGCT ACTCAACATT CAG CAGCAGT TGACCTGTAG CTTGCGGAGA 3 60

CTCGAG 3 66

(2) INFORMATION FOR SEQ ID NO: 516:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 329 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 516:

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GCGAGTGAGC CGGGGTAGCA TCACCTCACT CCAGCCTAGG TGATGACAGA GTTAGATTTT 6 0

GTCTCAAAAA AGAAAAAGAA AACAATTCCA GGATTATTAT TTCTACGTAA ATGTGACATA 12Q

TTATTTCTAT GATATTATTT CTTTGATCTC GTAGCCACAC TGTTCCCAAT AATGATTATG 180

AG AAAAAG TA CCCTCTGTTT GAAGGCAATC ATGGGGAAAA TATAATTCAC AAAGTATTTT 24 0

AAAATTAAAA TCCTGTGTAT TTCAAAAGAC GATGGTCCTA TTTTAAGAAA AATAAC CTTG 3 00

CAATT C ATTT GCTTTTTCAT TGGCTCGAG , 329

(2) INFORMATION FOR SEQ ID NO: 517:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 368 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

Cxi) SEQUENCE DESCRIPTION: SEQ ID NO: 517:

GAATTCGGCC TTCATGGCCT AGTCCTTTCA AGTACACAGA GAAATTTTGC TTGAATTTCT 6 0

GGAGGAAGAG TCCAGGGTTC GGGAAAAGGG ACTGGGTGGT ATCTATCTGG GGCCCCAGAC 12 0

AGCGGCACTT CTTTCTTCTG TGCTGGAATT CGGCGAACAA TCATATCATC TTTTTCCAAA 180

TCCGGAAGTA CAAGTTCACC TTCTCTACAC TGTAAAATTA TATCTCGCTC TACAGAATCA 24 0

TCTTGCTCAG AGAACTTTCT AAAGTCTTCA AAAGCTCGGA GAACATATGG ATTTGCATGG 3 00

AAAGCCCCAG TCTTTCTGAC AAAGAAATCA TCATTCTCTA AGTCAGGATC CAGGGCTGCC 3 60

ATCTCGAG 368

(2) INFORMATION FOR SEQ ID NO: 518:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 518:

GAATTCGGCC TTCATGGCCT ACGCTGAGAT CAAGATTCGG AGTTTGGGCT GCCTAATAGC 6 0

TGCAATGATA CTGTTGTCCT CACTCACCGT GCACCCCATC TTGAGGCTTA TCATCACCAT 120

GGAGATATCC TTCTTCAGCT TCTTCATCTT ACTGTACAGC TTTGCCATTC ATAGATACAT 18 0

ACCCTTCATC CTGTGGCCCA TTTCTGACCT CTTCAACGAC CTGATTGCTT GTGCGTTCCT 24 0

TGTGGGAGCC GTGGTCTTTG CTGTGAGAAG TCGGCGATCC ATGAATCTCC ACTACTTACT 3 00

TGCTGTGATC CTTATTGGTG CGGCTGGAGT TTTTGCTTTT ATCGATGTGT GTCTTCAAAG 360

AAACCACTTC. AGAGGCAAGA AGGCCAAAAA GCTCGAG 3 97

(2) INFORMATION FOR SEQ ID NO: 519:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 64 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

txi) SEQUENCE DESCRIPTION: SEQ ID NO: 51 9:

262

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GAATTCGGCC
CTCAGAAGAA
AGTAGACCTG
TGAGGAAGGT
GGCCTCGTTT
TTCAAAACCA
CACTGCAGAT
CCCAGCTTCT
CAAAAGCAAG
CGTCACAAGG
GGGAGAAGCA

TTCATGCCTA
G CAAAG C CTG
CCCCCAGGAG
TCATCAGGTG
TCCCAGGCAG
GCTCAGAAGT
GCTGAGCCTG
GAAGATTTAG
CGTTCAAAGA
AAGAGTGAGA
CAGAAGCCTT

CTTTGGTAAC
CATCTGAACC
CAGACCCCGA
ACCAGCCGCC
AGAGCAACGT
CTGAGGAAGC
ATGCAAACCA
AGGTTGATCC
CCCCTGTTCA
GGATAGACCG
TGGAATTAAA

AGAAGAGAAG ACTGTGGAGC CAGCTACCGT
TGCTCCTGCC CCTGTGGAAC AGCTGGAACA
TAAAGAAGCT GCCATGATGC CTGCGGGTGT
TTATCTGGAT GCCAAGCCTC CAACTCCCGG
AG AT C C AG AG CCTGACAGTA CCCAGCCACT
CAATGAG CCA AAGG C CG AAA AGCCAGACGC
GAAAGCCGAA GCTGCTCCTG AGTCTCAGCC
TCCAGTTGCT GCAAAGGATA AAAAGCCAAA
GGCAGCTGCA GTGAGTATCG TGGAGAAGCC
GGAAAAACTC AAGCGGTCCA ATTCTCCTCG
GACACTCGAG

60
120
180
240
300
360
420
480
540
600
640

(2) INFORMATION FOR SEQ ID NO: 52 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 469 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 520:

GAATTCGGCC TTCATGGCCT AGCAAGAGAA AGAGAAGTGC AAACACTCCC ACGGCGAAGC 60

GCCCTCCGTG GACGCGGATC CCAAGTTACC CAGTAG CAAG GAGAAGCCCA CTCACTGCTC 120

CGAGTGCGGC AAAGCTTTCA GAACCTACCA CCAGCTGGTC TTGCACTCCA GGGTCCACAA 180

GAAGGACCGG AGGGCCGGCG CGGAGTCGCC CACCATGTCT GTGGACGGGA GGCAGCCGGG 24 0

GACGTGTTCT CCTGACCTCG CCGCCCCTCT GGATGAAAAT GGAGCCGTGG AT CG AGGGG A 3 00

AGGTGGTTCT GAAGACGGAT CTGAGGATGG GCTTCCCGAA GGAATCCATC TGGATAAAAA 360

TGATGATGGA GGAAAAATAA AACAT CTTAC AT CTTCAAGA GAGTGTAGTT ATTGTGGAAA 42 0

GTTTTTCCGT TCAAATTATT ACCTCAATAT TCATCTCAGA ACGCTCGAG 469

(2) INFORMATION FOR SEQ ID NO: 521:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 202 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:521:

GAATTCGGCC TTCATGGCCT ACCCGTTTCC TCTAGTTTCT TCCTGTAGTA CTCCTCTTTT 60

AGATCCTAAG. TCTCTTACAA AAGCTTTGAA TACTGTGAAA ATGTTTTACA TTCCATTTCA 120

TTTGTGTTGT TTTTTTAACT GCATTTTACC AGATGTTTTG ATGTTATCGC TTATGTTAAT 180

AGTAATTCCC GCGGCCTTCA TG 202

(2) INFORMATION FOR SEQ ID NO: 522:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 92 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

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PCT/US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 522:

GAATTCGGCC TTCATGGCCT AAATTTAATG AAGCAAAATT CCATACATCA TTTTGAAAAT
AGTGTTTCTT TCCCTGATAG GCCTGTTCTG CATCATTCTT TTAGCTTCCT TCTGCCCTGT
TTATCACTTG GTCCCACTTT TATATTTTTC CTCTTCGGTC CAGAATTTCT TATTTAGTTT
CTTGTATTTT GCCTACTCCC TCCCTTCTCC ATGATTCAGC CTAGTCTTTC CGTCCTCTGT
GGACTTGGGT GTGCCTTCCT CTGGGCCACC TCGTCTTTTG CTGCTGTTAG CCCTCCCGCC
TGCGCACCTG CCACTTCACC CTCGCCTGTG GTCCACTTAC GTTCCACTCA GCCCGGTCAG
TCCTGCTTTG TTCTTCTCCA CCGCCTTGGT CTCCCGTGTG TCTTATCTAG CTCTGGTTCC
TTCTCGTCTC CACATTTATT TTGTTTTCTT CCTGTGCTTG TTAGTCCTTG TGCACTTGGC
CCTTTTCTCG AG

60
120
180
240
300
360
420
480
492

(2) INFORMATION FOR SEQ ID NO: 52 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 94 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:523:

GAATTCGGCC TTCATGCCTA GGAAATTTCA CCATTTGGTC TCCCCCTTTG TGGGT CAGCA 6 0

GGTGGTCAAG ACAGGGGGCA GCAGTAAGAA GCTACAGCCC GCCAGCCTGC AGTCTCTGTG 120

GCTCCAGGAC ACCCAGGTCC ATGGAAAGAA ATTATTCCTT AG ATTTGAT C TAGATGAAGA 18 0

AATGGGGCCC CCTGGCAGCA GCCCAACACC AGAGCCTCCA CAAAAAGAAG TGCAGAAGGA 24 0

AGGGGCTGCG GACCCAAAGC AGGTCGGGGA GCCCAGCGGG CAGAAGACCC TTGATGGATC 300

CTCACGGTCT GCAGAGCTCG TCCCCCAGGG CGAGGATGAT TCTGAGTATT TGGAGAGAGA 36 0

CGCCCCTGCA GGAGATGCTG GGAGGTGGCT CGAG 394

(2) INFORMATION FOR SEQ ID NO: 524:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 600 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:524:

CGATTGAATT CTAGACCTGA CCAAAGACCT TCCGTACAGA TTGACCGCAG AATGTCAGGG 60

AAAGTTAGGA. GAAGAAGTTC TGAGAAGACT GACTACAGAT TGGCTGGCCT GGCTGACCCA 120

GGAACTTCTG AGCAGACTGA CCTCAGATTG TATGGCCTCG TTGACCACAA AACAT CTGTA 18 0

AAGACTCACC ACCAAGTGTA CGGCCAAGCC ACTGAACTAG CTGAACACCA GGCTATTGAC 24 0

CAAGCTCATA GTAATGCTGA TCAACCTCCA GTTGACAATG CTCACTACAC TGAATCTGAC 3 00

CAGACTGACC ACTTAGCAGA CAGACAAGCT AATCATAAAG ACCAGCTGTC TTACTATGAA 360

ACACGTGGCC AGTCTGAAGA CAGAATATTT CCCCAGTTAG GCAACAGCAA AGAGGACAAA 420

GAGGCTGACT ACAGAGTACA ACCCTGCAAA TTTGAGGATA GCCAAG TAGA CCTCAATTCC 480

AAGCCTTCAG TTGAAATGGA AACTCAGAAT GCAACCACTA TCCCACCCTA CAACCCAGTT 540

GATGCCAGAT TCACCAGTAA ATTCCAAGCA AAAGAC CAAG CTCTTTTCCC AAGACTCGAG 6 00

(2) INFORMATION FOR SEQ ID NO:525:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 66 base pairs

264

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<B> TYPE; nucleic acid
(C) STRANDEDNESS : double
(D> TOPOLOGY linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 525:

GAATTCGGCC TTCATGGCCT ACTTTCTTCT GCTGGCTTCC ATCTTGCCAC ACTTTCTTGC 60

TCTTCCTTCT AACTGAAAGA CTACTTCTCC ATCCCCTCTG CAGGCTCTTT TGCTCCACCT 120

GATATTTAAA TGTTGGAATG CCTAGAGTTG TTCTGACCCT TCTTTATCTA CCCCGATTTC 180

CTCAGTGATC TTATGCAGAG GTCTCCCAAA GTTTACATGG CTATCCTTGA CCTCCTTCCT 24 0

GAACTGCAGC TGGTGTCAGC TGCCGTCACT TGGATGTTTA ATCAGCAACT CAAGGTTTAC 3 00

GTGATGATTA GACCGCAGTT ACCCCCAGAC TTCCTTATCC CTTAGTTTTC CCCATCTCAT 3 60

TAAGTTCACT TCCATTCACC TTCTTGATGA AGCCAAGTAT TT CAGAACTA GCCTTGTTTC 4 20

TTCTTTTTCA CTTTCCCCCA TATCAATTCC AGACTACCCA CTCGAG 4 66

(2) INFORMATION FOR SEQ ID NO: 526:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 559 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 526:

GAATTCGGCC TTCATGGCCT ACATTGTAGA AGAGATCACA GAAACCACAA AAGGTTTTCT 6 0

GAAGTATATG GATAATCAAT CATTTG CAAC TGAAAGTCAG GAAGGAGTTG GTTTGGGACA 120

TTCACCTTCA TCCTATGTGA ATACTAAGGA AATGCTAACC ACCAATCCAA AGACTGAGAA 180

ATTTGAAGCA G ACACAG AC C ACAGGACAAC TTCTTTTCCT GGTGCTGAGT CCACAGCAGG 24 0

CAGTGAGCCT GGAAGCCTCA CCCCTGATAA GGAGAAGCCT TCGCAGATGA CAGCTGATAA 300

CACCCAGGCT GCTGCCACCA AGCAACCACT CGAAACTTCC GAGTACACCC TGAGTGTTGA 360

GCCAGAAACT GATAGTCTGC TGGGAGCCCC AGAAGTCACA GTGAGTGTCA GCACAGCTGT 420

TCCAGCTGCC TCTGCCTTAA GTGATGAGTG GGATGACACC AAATTAGAGA GTGTAAGCCG 4 80

GATAAGGACC CCCAAGCTTG GAGACAATGA AGAGACTCAG GTGAGAACGG AGATGTCTCA 540

GACAGCACAA GGCCTCGAG 559

(2) INFORMATION FOR SEQ ID NO: 527:

(i) SEQUENCE CHARACTERISTICS j

(A) LENGTH: 318 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

• (ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 527:

GAATTCGGCC TTCATGGCCT ACG CAGTGGT TCAATTTTCT TCGAAACGGT GTGGTCCCTG 60

CAAAAGGATG TTTCCTGTTT TCCATGAGCT GG CTGAAACT TGTCACATCA AAACAATACC 12 0

CACATTTCAG ATGTTCAAGA AAAGCCAGAA GGTAACCCTA TTCTCAAGAA TCAAAAGAAT 1B0

AATTTGCTGT TATAGAAGTG GATTCATGAG CAACCTGATT TTTGAGTTTT GTGGAGCCGA 24 0

TGCTAAAAAA TTGGAAGCCA AGACTCAAGA ATTAATGTAA GCTGATCTCC AAGGCAAAAT 300

ACACTTGTGC CGCTCGAG 318

265

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PCT/US98/069S6

(2) INFORMATION FOR SEQ ID NO: 52 8:

<i) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 2 76 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 528:

GGCACAGACT TACCGGACAC ACAGGTCATG GGACACAGAG TCATGGGGCA CACAGGTTCA 60

CAGGGCACAC AGGCTCACGG GACACAGAG T CATGGGACAC ACAGGCTCAC AGGGCACACA 120

GGCTCACAGG ACACACAGGT TCATGGGGCA CAGAGTCATG GGGCACAGAC TCACAGACTC 180

ACAGGTCATA GACGCTCATG GGGCGCAGGC TCACAGGGCA CACAGACTCA GGGCACACAG 24 0

GCTCATGGGG CACAGAGTCA TGGGGCAGGG CTCGAG 276

(2) INFORMATION FOR SEQ ID NO: 529:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 180 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 52 9:

GAATTCGGCC TTCATGGCCT ATTCTGTTCT TTAAATTTGA ATGAAAGTTT GGCATTTTAA 60

AAAACTTTAG GTGATTTAGG AGTATAATTT TAAG CAGATT TTTAGAGTAC GAGTGTCCAC 12 0

ATATTTAACT AAACATTCAA AAATTAGTTA AAATCAATGA ACTTGGGAAG GATCCTCGAG 18 0

(2) INFORMATION FOR SEQ ID NO: 53 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 70 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 53 0:

GGGGACAGAA
TGGGGCCTGG
TCTGCACTGC
TGTACGTCTT
GCCTGCAGCT
AGCCACTCGC
ACGAGACCCA
AGCTGGAAAT

GATGTGCTCC AGGGTCCCTC TGCTGCTGCC GCTGCTCCTG CTACTGGCCC
GGTGCAGGGC TGCCCATCCG GCTGCCAGTG CAGCCAGCCA CAGACAGTCT
CCGCCAGGGG ACCACGGTGC CCCGAGACGT GCCACCCGAC ACGGTGGGGC
TGAGAACGGC ATCACCATGC TCGACGCAGG CAGCTTTGCC GGCCTGCCGG
CCTGGACCTG TCACAGAACC AGATCGCCAG CCTGCCCAGC GGGGTCTTCC
CAACCTCAGC AACCTGGACC TGACGGCCAA CAGGCTGCAT GAAATCACCA
GGCCCTTCAG CACCGTTCAC AGTATTTTGA AGGTGTTGTG AAGTGCAATA
ACTGGAGACC ATCGTGGACA GAATAGTAAG AGCCCTCGAG

60
120
180
240
300
360
420
470

(2) INFORMATION FOR SEQ ID NO: 531:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 553 base pairs

266

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(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
(D} TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 531:

GAATTCGGCC TTCATGGCCT AGAAAATTCC AGAAAGGATA TTTAAGAAAA TACAATAAAC 60

TATTGGAAAG TACTCCCCTA ACCTCTTTTC TGCATCATCT GTAGATACTA GCTATCTAGG 120

TGGAGTTGAA AG AG TT AAG A ATGTCGATTA AAATCACTCT CAGTGCTTCN TACTATTAAG 180

CAGTAAAAAC TGTTCTCTAT TAGACTTTAG AAATAAATGT ACCTGATGTA CCTGATGCTA 24 0

TGGTCAGGTT ATACTCCTCC TCCCCCAGCT ATCTATATGG AATTGCTTAC CAAAGGATAG 3 00

TGCGATGTTT CAGGAGGCTG GAGGAAGGGG GGTTGCAGTG GAGAGGGACA GCCCACTGAG 360

AAGTCAAACA TTTCAAAGTT TGGATTGTAT CAAGTGGCAT GTGCTGTGAC CATTTATAAT 420

GTTAGTAGAA ATTTTACAAT AGGTGCTTAT TCTCAAAGCA GGAATTGGTG GCAGATTTTA 4 80

CAAAAGATGT ATCCTTCCAA TTTGGAATCT TCTCTTTGAC AATTCCTAGA TAAAAAGATG 54 0

GCCTTTGCTC GAG 553

(2) INFORMATION FOR SEQ ID NO: 53 2:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 843 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53 2:.

GAATTCGGCC AGAGAGGCCT ACTTCTCTTA GTGATTTCAT GTTTCAACCA GTACATTGTG 60

GTGAATACTG AAATATCTTG TTTAATTCAG ATAATTAAAA TGGTGG CAAA GGAAGCTGTT 120

TAGCCAGAGC CCTTCTTGAC TTTGAGGAAC AGTGGTAGTA TAAGACTTGA AGACAGACGT 180

GTAAAAAGTA CTACTCACTG GTAGGCTCAG GTCTGGTTGA TTGACTGATT CTTGAGACGG 24 0

AATGTCGCTC TGTCGCCTAG GCAGGAGTGC AGTGGCCCAG TCTCGGCTCA CTGCAGCCTC 3 00

CGTCTCCGGG TCCAAGCGAT TCTCCTGCCT CAGCCTCCCG AGTAGCTGGG ACTACAGGCG 360

CCCGCCACCA CACCGGGCTA ATTTTTGTAT TTTTAGTAGA GACGGAGTTT CACAATATTG 420

GTCTCGAACT CCTGACCTCA GGTGATCCAC TCGCCTGGCC CACCCAAAGT GCTGGGATTA 4 80

CAGGGATGAG CCCCTGCGCC TGGCCTCGGT TGAATTTATT AAACAACTTT TGTGGGCAGC 54 0

AAGCTGTACG AGGTTAACTA TGTGATGAGA AGACTTAGAA ATGGAGAAAA GTTTTATCAG 600

TTCTACATAG GACTTAGTTT GGGAGTTTCT GGAAACTACG TTGGAAATCA GTAGTTGCAC 660

ACTAGCTGAA TTCAGCTGTG TAATTTACAG TGATTTGTTA TTTACCAAAT AAGTAGAAGA 720

GGGAATTAAG AAGCTAAAAT CTCTGGGTAC TTGTTTGATA TGAATTTGTT AATTGTTTAT 780

ACTCAGGTAA TAAGTGTTAC CTCAGTCATA GCATTTAATA TTTTATCTGA CTGTCCTCTC 84 0

GAG 843

(2) INFORMATION FOR SEQ ID NO: 53 3:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 525 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 533:

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GAATTCGGCC AAAGAGGCCT ACATCCAGAA ATTTAGGGAC TCAGCCCTGG TCAGGGTGGC 6 0

AAAGGGTCTG TTTGTCTTTC CCCATTAGAC AGAGGTCTTG TCCTGCTACC CTAATTGTAA 12 0

AGGGGTGCCT GGGAAGGGGT GGTAGGGACA TGGTGGCGGT GGAGACTCCG GCCCCACTTC 180

TCCAGGCTTT GCTGACAGGG GCCTGCTTTT AATTTTTATT TTTATTCCAT GACTTTTTAA 240

AAAAGAATCC CGTAACTTCT TTTTCATAAC TTTTTTTGTA ACTTTTCATA ATACTGTTTT 300

CTACTTTGTT CCCACAAGTT TTTTTGCCAC AACGTTTTTA CATTTTTTAT CCCATAACTT 3 60

TTTCACCCCA TAACTTTTTT AAATAAAGTT ATTTAATAAA ATAACTTTTT ATAAAACTTT 4 20

AATAAAAGTT TTTTAATTAA CCCATAACTT TTTTATTTTG GTTTTTAATA AACACTTGCA 4 80

TAGTTATATT ACAACTTTGT AAAAATGAAA CACATTATCT CAGGC 525

(2) INFORMATION FOR SEQ ID NO: 534:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE .TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 534:

GAATTCGGCC AAAGAGGCCT AGAAAACCCT TGAAGACATG TTGAAAATAC ATACTCCTGT 6 0

TAGCCAAGAA GAAAGATTGA TTTTCTTAGA CTC CATTAAG TCCAAATCCA AAGACTCTGT 120

GTGGGAAAAA GAAATAGAAA TACTTATAGA GGAAAATGAG GACCTCAAAC AACAATG TAT 180

TCAGCTAAAT GAAGAGATTG AAAAGCAAAG GAACACTTTT TCATTTGCTG AAAAAAACTT 24 0

TGAAGTTAAC TATCAAGAGT TACAAGAG 268

(2) INFORMATION FOR SEQ ID NO: 53 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 224 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53 5:

GGCTTGCACC TCGGCGATCC CCGACTCCCT TCTTTATGGC GTCGCTCCTG TGCTGTGGGC 60

CGAAGCTGGC CGCCTGCGGC ATCGTCCTCA GCGCCTGGGG AGTGATCATG TTGATAATGC 12 0

TCGGAATATT TTTCAATGTC CATTCCGCTG TGTTGATTGA GGACGTTCCC TTCACGGAGA 180

AAGATTTTGA GAATGGCCCC CAGAACATAG ACATTCCTCT CGAG 224

(2) INFORMATION FOR SEQ ID NO: 53 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 03 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 536:

GAATTCGGCC TTCATGGCCT ACCACTCTGG CCCCAGCGTC ACTGGCCTAG GGACACATGG 6 0

GGGTGGGGAT TGTTTGGCCT TCCTGGCTTA GGTCTCTGGA AGAGAGAAGA ACCC CATGGG 120

268

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GCAGACCCAG GCCACGGGCA GTACATGCCT CCCACACTAC TGACACCGCC AGTGTCTTCT 180

GTGAAGCCAC CTTTG AG CAA CGGAAAGGAA GGGGGATGGG CAAGATCAGT GCAAGGTTGG 24 0

CCAAAAGCCT GGGGCTGGCC TTCTGCTGGC ATGAGAGGGC CAGGCCGCCC CCAGCTCCTC 3 00

GAG 3 03

(2) INFORMATION FOR SEQ ID NO: 53 7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53 7:

GAATTCGGCC TTCATGGCCT AGAACAAAAT CTGAAATTCA GAAATAAACA ACAGTTGGAA 60

AATATTTTCC ATTTTTTTCC CTATTAAATA TGATAATTTC AGGTG CAAAG AGTGTTTTTT 120

TTTTTTTTTT TTTCTCCACA GTGCTTTTCA CGGTGGGGAC TAATGGATAT AGAGGGTGGG 180

AGG CCAGAAT AACCAAGTAC CTGGAAGTGA ATCTTTGTGG AGATAATGAA ATAATTTTAT 24 0

TCGAAAGGTG CAAAAGGAAG TCTTCCATCA CTAGCTCAGC TGTTATGGTC CTTGAACTGC 3 00

CCTTGCCCGT CTGTCTTTTT ATTAATCCTT TTTACCTGTC GAGTCTCGAG 3 50

(2) INFORMATION FOR SEQ ID NO:53B:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 344 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 53 8:

GAATTCGGCC TTCATGGCCT AGAGTTGCAC AGATGTCTTT TGTTAGCTTT GGTGG CGGAG 60

TCATCCTCAC AGACCGTTAC TCAGATAATT AAGTGCCTTG CAAATTTAGT AT CAAATGCA 120

CCTTATGATC GTCTAAAACT CAGCCTGCTG ACCAAAGTCT GGAACCAGAT AAAGCCTTAT 180

ATTCGCCACA AAGATGTTAA TGTTCGTGTG TCAAGTCTCA CACTCTTGGG AG CTATAGTG 240

TCCACCCACG CACCTTTACC TGAAGTCCAA CTACTTCTGC AACAG C CATG TTCTTCTGGA 3 00

CTCGGTAATA GCAATT CAGC AACCCCTCAC CTCAGCCCCT CGAG 344

(2) INFORMATION FOR SEQ ID NO: 53 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 343 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 53 9:

GAATTCGGCC TTCATGGCCT ACAACTCCAT TAAACCACCA CCAGCTCCCC AAGCCACCCC 60

TTCAGCCATG AAGTTCCTGC TCCTGGTCTT GGCAGCCCTC GGATTCCTGA CCCAGGTGAT 12 0

CCCAGCCAGT GCAGGTGGGT CAAAATGTGT GAGTAACACC CCAGGATACT GCAGGACATG 18 0

TTGCCACTGG GGGGAGACAG CATTGTTCAT GTGCAACGCT TCCAGAAAAT GCTGCATCAG 240

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CTACTCCTTC CTGCCGAAGC CTGACCTACC ACAGCTCATC GGTAACCACT GGCAATCAAG 3 00

GAGAAGAAAC ACACAAAGGA AAGACAAGAA GCAACCCCTC GAG 343

(2) INFORMATION FOR SEQ ID NO: 54 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54 0 :

GCGATTGAAT TCTGAAGACC TCTCAGCCTC TTATG AC C AC TCCTGGCACC CTGTCAAGCA 60

CAGCATCTCT GGTCACTGGC CCTATAGCCG TACAGACTAC AG CTGGAAAA CAGCTCTCGC 120

TGACCCATCC TGAAATACTA GTTCCTCAAA TCTCAACAGA AGGTGGCATC AGCACAGAAA 180

GGAACCGAGT GATTGTGGAT GCTACCACTG GATTGATCCC TTTGACCAGT GTACCCACAA 240

ATCTCGAG 24 8

(2) INFORMATION FOR SEQ ID NO: 541:

(i) SEQUENCE CHARACTERISTICS :

(A> LENGTH: 433 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54 1 :

GAATTGGCCT TCATGGCCTA GATTGTCTTT ATAGGAAATG TCTTTAGCAA AATACTACGG 60

GTTCTATAAA ACCCATTAAC GGGTTAT CAG TGTCTAGGAC ATAAATGGCT TCTGGTAAGA 120

AAATTAAGGT CTACTCTCCC TAAATACTAT CATAATTACA AAGGTTAAGA AAAAAGAAGT 180

AGAGTAAAAC ATGTGTCCCT TAAAAATCAA ACATGAGTGG TCACAAGGTC CTAAGAAGCA 24 0

GAGAATGAGA ACTCCAGTTG CTTGTTTATC TCTCAGGCTG AG CATG GTTG GTTACAATGA 3 00

GGGGTAGCAG GAAGAGCACA GCCTTGGACT CCAGTCCAAG GAACTCCAGT CTCTCCTGCA 3 60

ATTTCCCAGT GTTTGACCTT GGGCCACTTA CTGTTCCTTT CTCAGCCTCC ATTTTCATAT 420

CTAAAACCTC GAG 43 3

(2) INFORMATION FOR SEQ ID NO: 54 2:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 93 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54 2:

GAATTCGGCC TTCATGGCCT AGACACGGGA CATAAAAACT TTTAATGAAG GAGGACACAG 60

CTCAGAGCCC TTCCACATGC GGCCCAACCC TGCCCCACGG AGACCGG CCA TGGCAACCGC 12 0

TCAATCAGAA GGTGTTCTTG ATGCGGCCGG CCACCAGCCT AAGGATGTCC CCGATCTTCT 180

TCTGCCAGTT GGCGATGTCC TTGGACACGG CGCACCACAG CTCCCCATGC CGAGGCTCTG 24 0

CACTCTCACA GCGCTTCCTC ACCTCCTCCT GCTGCTCCTC AGTGCCATGC TGCAGCTCAA 3 00

270

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ACTTGTAGAA GAAGGCCCAG GCATCCCCCA GGTCCGAGTC AATCTTCACA GTGCGGTGGA
ACCACTCCCT GGCCTTGGTG ATCTTCCGCT GACTCCAAAA CAGCTTGGCC ACGGCCAGGA
GCACATGGGG GTCATGCTCA CACTTCTTCA GGGCATCCAC GCTCTTGGTC CTCCTCTGGG
GCCTTGCCTC GAG

360
420
480
493

(2) INFORMATION FOR SEQ ID NO: 54 3:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 325 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:543:

GAATTCGGCC TTCATGGCCT AG T CAGGGAG AAGGGAAGGT GAGAAGGGGG GGAAAAAAGA 60

AGCAAAAAGC CCAAAGAAAA AAACATTTTA TATTCATCTG TATAAACATA TCCGCTAAGG 120

CAAACG CAAT CCGGGTCCGA GGCTGCTGCG CTGGGCTCGG TGCCTCCTAA TTTCTGCAGA ISO

TTCTAAGGCC AAAAAATAAA AC CTCTG CAA GTCCGCGTAG CTTCCAGGAC TCCTGGGCAT 24 0

TTTACTAAAA TAAAGAGTTA TCGAGTTTAA AAAGCAG TG A CGTCGTTATG ACACACACTG 3 00

AAAG TTGCAT AACTGTGGCC TCGAG 325

(2) INFORMATION FOR SEQ ID NO: 544:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 473 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 544:

GAATTCGGCC AAAGAGGCCT AAGAATTCCT TATGAAAG TG ATGCTTGAGT CAAAATATGA 6 0

TGGATGAAGA GAGTTTAAAT AGATTACATA GAATTTTTAA TAATGTCGAT TGGTTATATA 12 0

CTGGGCACTG ATAGCTGATT TTTCTTTGGG GAAAGGTATG TCAGCCTAGT CATTCAGATT 180

CCTTTATTTT TTTAAATGTT TTTTCATTTT TTGCTTTGCA TTGCATTCAT TTGCTGAAGA 24 0

GCTGGCTTGT ACTTTGGCAG GTGTCATACT TGGTTATTCT CCTTAGGATA TTGGCCCAAC 3 00

AATCTGGGAT TTGTGAAAGG CGCTTCGCTT TTCAGACCTG GGCGTCTGTA TCATGACTAT 36 0

CATAAATTTA GGATTAAGAC ACCTAGCCTC ' CTACCAGGAT GAATGAGGTG TCCATGTGAC 42 0

CTGCTGTGCC CTGGAATTTT ATACATCTTT CTCTCATAGC ACACGGACTC GAG 473

(2) INFORMATION FOR SEQ ID NO: 54 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 120 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 545:

GAATTCGGCC AAAGAGGCCT AGTCGAGAAG GAAGAGGGAA GAAGAAAAAC TATAAAAGTG 6 0

TGCTAAATGT TTTATTTTCT CTGGAAGAAT AGTTATATTC TACTCTTTGT GGCTCTCGAG 120

271

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PCT/US98/06956

(2) INFORMATION FOR SEQ ID NO: 54 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 81 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS ; double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:546:

GCTAGACCTG CCCCCTTAGA AATGGAAAAA GCATGCAAGA GAGATGTTAA AGGAGACTAT 60

TGGAGCAACT GTGTCCACAC CCTCTGTGAT AGAAATGGAA AAAATATCCC CAGAAGATCG 120

TGGTGAGAAT ATTGG GAAAC ACAAAG TGTT ACCCGCAGTG GTAGACATTG AGAAAATACA 180

TGGAACAGGA CTAGAATTGA C CACTAAACA AGGGGAGGCC ATGCTTCCTG CATTTGAAAG 24 0

TAAAAC AC CA CAAGAGTATG CTGAAGGGAG TGTTGAAGAA ACAATGGAAA ATACTTACCA 3 00

AAAGGATGCT GAAGGGGATA TTGGAAAGGC TGAAGTGATG CCTGTGAGGT TAGAAATGGA 3 60

AAATACTTAC CCAAAGGATA CTGAAAGAGA CGGTGGCAAA ACTGAGGTGA TGCCCCTTGC 420

ATTAGAGGTA GTAAATACTT ACCAAAAAAA TGCCAAAGGT TTTACCGGGA ACAATCTCGA 4 80

G 481

(2) INFORMATION FOR SEQ ID NO: 54 7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 05 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 547:

GAATTCGGCC AAAGAGGCCT AGAAACCTGA GG CTGCTGCC CTTTATCTGC CTTCACGGTA 60

CTGTCCCCTT CCCCCAGCTC CTCCCTGACC CCATGGGCCA GGCCTCAGAC CTTCCAGCTA 120

ACCGCTTCCC ATGAGCCACT ACTCTGATGT CAGCCTATAA CCAAAGGAGC TGGGGGGTCC 180

AGGCCTGGTG ACCAACCTTT CTCAGCCCAC TCAATCAGGG TGCTCCCCAC CTGCAGGCAG 240

GAGGCAACAC CCTATCTGCT ACCATCAGCC CCTTCCAGAG CCCATCTGCC CCGCCCAGCC 3 00

CTGCCCTGCC CAGCCATACC CTGCTCTGCC CCATCTGGGG GTGCCCTGCT CAGGGATGGG 3 60

CTGGCAGGGC TGTACCCAGC CTCCCTGGTA AGCAAAGAGC TCGAG 4 05

(2) INFORMATION FOR SEQ ID NO: 54 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 2 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54 8:

GCGATTGAAT TCTAGACCTG CCTCCCTGCT TTC TAATAAA TCTGACTAAC CTTAGACATT 60

TTGTATCTTA CTAAGAACAT CCCTT CAATA TCTACTTCAT TATC CCATG C CATTTCCCCA 120

CTGTCTCAAC ACGAATCTCG AG 14 2

(2) INFORMATION FOR SEQ ID NO: 54 9:

272

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 96 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54 9:

GAATTCGGCC TTCATGGCCT ACTATGGTAT TGCTAAACAA GGGTGGGAGG AGAGAGAGGT 60

AATCAGGGAG GACTTCCCAC AGGAGGTGGC AT CTG CAG AT GTCTCAAAAA AGAAAAGAAT 120

TAGCCTGGCA AGAGGTGAGG ATTGTGTAGA GGTCACTCAC TTTCCTTGTG GGTGGAGGAA 18 0

AC CATTC CAG GAGCTGTAGG AAGCTTGGTG CTGGTGAAGG AGGCAGGAGA GGAGAGAAGA 24 0

GGAGATGACC TTAGAAAT CA CATCCAAGAG CCTCTGATCC CAGGAGGCAG CTCGAG 296

(2) INFORMATION FOR SEQ ID NO: 550:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 254 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 550:

GCAGGAGAGA AAATTGAGGC TTAGGTTAAG AAACTTACCC AAAGTCAAAC AATTTAATTG 60

GTTTGGGAAG ACCAGGAAGA CTTTAAGTTC CTAAGATCGT TTGAGATTCT G CAT CAGGG A 120

ACACTTGACA GCAGGTTTAT ACAAAGACAG ATTTGGTATC TTTGGAGGGA ATGAGTTTCC 180

AGTCATTGCA GGTGGTCCAG CAG AGAGGG C CACTCTCCTT TTTTTCTTTC TTTACTCCCT 24 0

TTTTGATTCT CGAG 254

(2) INFORMATION FOR SEQ ID NO: 551:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 278 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:551:

AGGCCATGAA GGCCCTTTCC ATTTCTTTTT GTTCCATCAC TCTTCTCTCA ACCTGTGTTT 60

CTTTTTTTAC TGAGGAGTTA GTCCCCATTA GTTCTTGTAT CACATTTTCA TTTGCACGAC 120

ATTACTCGCA GGTGGTGGGG AGCCTGGGCT TTTGGGGAAC CAGGCTGCTC TGGTCCCCAG 180

CATTGCCTCC TCCTAGCCCC T CTAGTC CAG TTTGCCTCCC TTACCCTCAT TTTCCAAACC 24 0

TCTTGTACCC TCCTCTCCCT CCCCCAGCTG GC CTCGAG 278

(2) INFORMATION FOR SEQ ID NO: 552:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 322 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

273

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 552:

GAATTCGGCC TTCATGGCCT ATGCACTTCT TCTTTCTCTC CTCCTTTTGC TGGGTGCTTA 6 0

CCGAGGCCTG GCAGTCCTAC CTGG CTGTCA TTGGGCGGAT GCGCACCCGC CTCGTTCGCA 12 0

AGCGCTTCCT CTGCCTGGGC TGGGGTCTGC CTGCCCTGGT GGTGGCCGTG TCTGTTGGCT 180

TTACCCGAAC GAAAGGATAC GGTACATCCA GCTACTGCTG GCTCTCCCTG GAGGGCGGCC 24 0

TGCTCTACGC CTTTGTGGGC CCTGCAGCCG TCATTGTCCT GGTGAACATG CTCATCGGAA 3 00

TCATCGTCTT CAGCAGCTCG AG 3 22

(2) INFORMATION FOR SEQ ID NO: 553:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 90 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 553:

GCCAAAATCA AG C AAAGT AT GAAGAAAGAT AAAGAAGGGG AAGAAAAAGG GAAGCGAAGA 60

GGATTCCCCA GCATCCTGGG ACCCCCACGG AGACCAANCC GTCATGACAA CAGTGCAATT 120

GGCAGAGCCA TGGAACTACA GAAGGCGCGC CACCCTAAGC ACTTATCCAC ACCCTCATCT 180

GTGAGTCCTG AACCTCAGGA CTCTGCCAAG TTGCGCCAGA GTGGGTTAGC AAATGAAGGA 24 0

ACAGACGCTG GATACCTGCC TGCCAATTCC ATGTCTTCTG TAG CTT CAGG GGCCTCTTTT 3 00

TCCCAGGAAG GAGGGAAAGA GAATGATACA GGATCAAANC AAGTTGGAGA AACATCAGCA 3 60

CCTGGAGACA CCTTAGATGT CACCCTCGAG 3 90

(2) INFORMATION FOR SEQ ID NO:554:

<i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 06 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 554:

GACGGCTACA CCATGGGCCG GCTGCTGCGG GCCGCCCGGC TGCCGCCGCT GCTTTCGCCG 60

CTGCTGCTTC TGCTGGTTGG GGGAGCGTTC CTGGGTGCCT GTGTGGCTGG GTCTGATGAG 120

CCTGGCCCAG AGGGCCTCAC CTCCACCTCC CTGCTAGACC TCCTGCTGCC CACTGGCTTG 180

GAGCCACTGG ACTCAGAGGA GCCTAGTGAG ACCATGGGCC TGGGAGCTGG GCTGGGAGCC 240

CCTGGCTCAG GCTTCCCCAG CGAAGAGAAT GAAGAGTCTC GGATTCTGCA GCCACCACCA 300

CTCGAG 306

(2) INFORMATION FOR SEQ ID NO: 555:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 327 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

274

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 555:

GAATTCGGCC TTCATGGCCT ACCCTCTCAC GCCACCCCCG CCCCCACCGG GCTGCAGGTG 6 0

CTGCTGATGC GCTGGGATCT GATTGAGGAT AAAAAGGAAG GAGAGATGAC CCCTACCCCC 12 0

TCATCCCCCA GTTTTGAAAA GGTCTAAGCA AGTGAGTCTG GTGGAGGAGC TGAGGGAGGG 180

AGCCATGGAA GGTGCCAGAA GGAAGGTTGG CGGGGGCACG TGTGGGCCGT GGCTTGGGCT 24 0

GGTCAGAGTG GCGTGAGCTG CCCGGCGCCT GCCCTGCCCA AGTGACCAGG GAAGTGTGTG 3 00

TGTGTCCATG TGTATGCGTG GCTCGAG 327

(2) INFORMATION FOR SEQ ID NO: 556:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 272 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 556:

GAATTCGGCC TTCATGGCCT AGAGAAGGAG CCAGCTGGGG CCGAATCCAT CCGCTTGAAC 6 0

ACCAAAGAAG ACAAAAATGG TGTCCCCGAC TTAGTGGCCC TGCTGGCTGT GAGAGACACC 12 0

CCGGACGAGG AGCCGGTGGA CAGCGACACT TCGGAGAGCG ACTCG CAGGA AAGTGGGGAC 180

CAAGAAACAG AGGAGTTGGA TAATCCTGAG TTCGTGGCCA TTGTGGCCTA TACCGACCCG 24 0

TCGGACCCCT GGGCCCGGAA GGAGAACTCG AG 272

(2) INFORMATION FOR SEQ ID NO: 557:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 B0 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 557;

GAATTCGGCC TTCATGGCCT ATTTCCGATC TATGTATCTG TACT CAT AC A GCCTCATCGG 60

GCTAAACAGC CTTCTTTTCA GAACAGTAGA TCACTCAACT GGGTTTTCAA GTGACTGTTT 120

ACCTTTCAAG GCTGGCTTTA TAGGTCTTGC CTCACTGTAT CCAGCAATCC AAACTT TACC 180

CTATCCCAGT CAGGACTGCA CACCTCATAT TGAAAGACAT ACCTTAGAAC CAGACTCCCC 240

AAACCTTACA AATATCCCAC CCTTGACTCC CGTTCTCGAG 280

(2) INFORMATION FOR SEQ ID NO: 558:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 74 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 558:

GCAATGGTCT CCAGGATGGT CTCTACCATG CTATCTGGCC TACTGTTTTG GCTGGCATCT 6 0

275

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GGATGGACTC CAGCATTTGC TTACAGCCCC CGGACCCCTG ACCGGGTCTC AGAAGCAGAT 12 0

ATCCAGAGGC TGCTTCATGG TGTTATGGAG CAATTGGGCA TTGCCAGGCC CCGAGTGGAA 180

TATCCAGCTC ACCAGGCCAT GAATCTTGTG GGCCCCCAGA GCATTGAAGG TGGAGCTCAT 24 0

GAAGGACTTC AGCATTTGGG TCCTTTTGGC AACATCCCCA AC AT CGTGG C AGAGTTGACT 3 00

GGAGACAACA TTCCTAAGGA CTTTAGTGAG GATCAGGGGT ACCCAGACCC TCCAAATCCC 3 60

TGTCCTGTTG GAAAAACAGC AGATGATGGA TGTCTAGAAA ACACCCCTGA CACTGCAGAG 420

TTCAGTCGAG AGTTCCAGTT GCACCAGCAT CTCTTTGATC CGGAAACACT CGAG 474

(2) INFORMATION FOR SEQ ID NO: 55 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 9Q base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 559:

GAATTCGGCC TTCATGGCCT AATTTTTTTG TTGTTGTTTC CTTTTTGTAT TTTACTGATA 60

TCACCAGGAT AGTTTACTCT CCTTCTAGCT TTCTGCTTAC CGCACACTGG ATAACACACA 120

CATACACACC CACAAAAATG CTCATGAACC CAATCCGGAG AAGGTTCCAG CAGGTCCCCC 180

ACCCTCCCCT CCTCCTCCTA CTTCTCCTCT TGACAGCGAG GACAGGAGGG GGACAAGGGG 240

ACACCTGGGC AGACCCGCCG GCTCTCCCCC CACCCCACCC CGTCCTCGAG 290

(2) INFORMATION FOR SEQ ID NO: 56 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 61 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
{D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 560 :

GTGTATGTGG GGGGTAAGTG TGTGTGTGTG CGTGTGCGTG TATGTGCACG TGTTGTGTGT 6 0

GTGCGCCTGC ACACGGAGAG CCCACTCATA CGTAG CAGAA AATCAAATGG CCCCAAATCA 120

GAAACATGGC GCATGTGAGC ATGCCACTTC TTGTGTGCCT GTGACTGTTC AGAATGTACA 180

CGGCCCTGCA GCTCCCGAAG GCCAGCTCTG CTGCAACCCC TCCTCTGTCC AACACAGTCC 24 0

TCACTGGTGT CTTTTCCTCT TCAAATCTAC AGCATTTCTG ATCTCTGCAA ACAATTTAAC 3 00

CCAAAACCAA GTTCTGGCTG ACAAGGCTAC ATCTTGTTTC TTGTGCGTGA TTAGCCTCGA 360

G 361

(2) INFORMATION FOR SEQ ID NO: 561:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 81 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 561 :

GTTCTAGACC TGCCTCGAGA TATGC CGGAA GGTTGCATGG CTGGTCCCAG GGCCAGCACA 60

276

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GGCCCGAGGC CGGGCTGCCT GGTTTTATTT TTATTTAACT TTATTTTCTG TTTTATGAGT 120

GTGTGTCCGC CCACCCCCAC CCCCTTCAGT GTTAAGTGGG GAGCCCTGGG GGAGTCTCTC 180

CTGCCTCCCA GCCTCTCCCA AGACCTCCCC CCTCGTCACC AGCCATCCCT CTGGACCAGG 24 0

CAGAGGGCGG ACCGGGTGGG CAGGGGCCTG AGGGTGGCTC GGGCCAGCCC ACCAGCCAAT 3 00

GGACCCCTCC TCAGGCCGCC AGTGTCGCCC TGCCCCTTTT TAAAACAAAA TGCCCTCGTT 36 0

TGTAAACCCT TAACGCTCGA G 381

(2) INFORMATION FOR SEQ ID NO: 562:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 317 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 562:

GCACTCATAA AAATC TTACT CAGAAATCTT CAGAGGTTTG CTAAGGATAC AATTTGATTC 60

TTACACATTT AATGCTCACC AGCTGCTTAG GCCCACACCA TTTATCCACC CTGATTTGCT 120

ACTGCTCTTT GAAATACAAC CAGTGTTTCA GCCAGACTGT TTTCCTGCTT CTGCTCCCCT 18 0

TCTCCTCCTC CCAGCACATC TGTGAATTCT TTGACTGGTT TACCACTCCC ACACTCCTCC 24 0

CCAGCAATGC AGATCTTCTA CACCCTTTAG GATCTAAGCT AAGTCTGCTT CCCAGATATC 3 00

CTCCCGAACA GCTCGAG '317

(2) INFORMATION FOR SEQ ID NO: 563:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 472 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY : linear

<ii> MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:563:

GAATTCGGGC TTCATGG CCT ACTTTAATGA GATAGGAACT AGTATATTCA CCGTCTATGA 6 0

GGCCGCCTCA CAGGAAGGCT GGGTGTTCCT CATGTACAGA GCAATTGACA GCTTTCCCCG 12 0

TTGGCGTTCC TACTTCTATT TCATCACTCT CATTTTCTTC CTCGCCTGGC TTGTGAAGAA 18 0

CGTGTTTATT GCTGTTATCA TTGAAACATT TGCAGAAATC AGAGTACAGT TTCAACAAAT 24 0

GTGGGGAT CG AGAAGCAGCA CTACCTCAAC AGCCACCACC CAGATGTTTC ATGAAGATGC 30 0

TGCTGGAGGT TGGCAGCTGG TAGCTGTGGA TGTCAACAAG CCCCAGGGAC GCGCCCCAGC 360

CTGCCTCCAG AAAATGATGC GGTCATCCGT TTTCCACATG TTCATCCTGA G CATGGTG AC 420

CGTGGACGTG ATCGTGGCGG CTAGCAACTA CTACAAAGAA GAAAACCTCG AG 472

(2) INFORMATION FOR SEQ ID NO:564:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 411 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:564:

277

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GCCGCGATGT TCCCCCTTCG GGCCCTGTGG TTGGTCTGGG CGCTTCTAGG AGTGGCCGGA 6 0

TCATGCCCGG AG CCGTG CGC CTGCGTGGAC AAGTACGCTC ACCAGTTCGC GGACTGCGCT 12 0

TACAAAGAGT TGCGTGAGGT GCCGGAAGGA CTGCCTGCCA ACGTGACGAC GCTTAGTCTG 180

TCCGCGAACA AGATCACTGT GCTGCGGCGC GGGGCCTTCG CCGACGTCAC ACAGGTCACG 24 0

TCGCTGTGGC TGGCGCACAA TGAGGTGCGC ACCGTGGAGC CAGGCGCACT GGCCGTGCTG 3 00

AGTCAGCTCA AGAACCTCGA TCTGAGCCAC AACTTCATAT CCAGCTTTCC GTGGAGCGAC 3 60

CTGCGCAACC TGAGCGCGCT GCAGCTGCTC AAAATGAACC ACCACCTCGA G 411

(2) INFORMATION FOR SEQ ID NO: 56 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 270 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 565:

CACTCAGAAC CCTCAGACTT TCAAAGAGCC AGGAAATCGG TATAAAATTT TTGAGATAAC 6 0

ATTAATTAAG CTTTTTGCAG TTTTTCCTAG GACCAGATTA AACAGAAGTT TTCCTTTACA 12 0

GTATTCATTA TGGTTGGTAT CTCCAGAGTT CATCCTTTTT TTGTGGTACT GGGAAAAGTT 180

GCAACATTTA CCTTTGCAGG GACATGGATG GAGCTGGAGG CCATTATCTT TAGCAAACTA 24 0

ACACAGAGCC AAAGACAAAA ACCACTCGAG » 270

(2) INFORMATION FOR SEQ ID NO: 566:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 272 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 566:

GTTCCTGTTG ACTAACGGCT CATCTTTTCC TTGTTTTTGT TTTTTTTTTG TTCTTTTTTT 60

CCATGTCACT AAAGGCCAAA ACTGGAACCA AGGATTTAAT AACTATTATG ATCAAGGATA 120

TGGAAATTAC AATAGTG CCT ATGGTGGTGA TCAAAACTAT AGTGGCTATG GCGGATATGA 180

TTATACTGGG TATAACTATG GGAACTATGG ATATGGACAG GGATATGCAG ACTACAGTGG 240

CCAACAGAGC ACTTATGGCA AGGCATCTCG AG 272

(2) INFORMATION FOR SEQ ID NO: 567:

(i) . SEQUENCE CHARACTERISTICS :

(A) LENGTH: 306 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 567:

GCAATGGCAG GAATTCGAAA TATTGG CATA TGGTTCTTTT GGATTAGATT ATATAAAATC 60
AGAAGAGGTA GAACCAGGCC CCAAGCACTC CTTTTTCTCT GCATGATACT TCTGCTTATT 120
GTCCTTCACA CTAG CTACAT GATTTATAGT CTTGCTCCCC AATATGTTAT GTATGGAAGC 180

278

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CAAAATTACT TAATAGAGAC TAATATAACT TCTGATAATC ATAAAGGCAA TTCAACCCTT 24 0

TCTGTGCCAA AGAGATGTGA TGCAGAAGCT CCTGAAGATC AGTGTACTGT TACCCGGACG 3 00

CTCGAG 306

(2) INFORMATION FOR SEQ ID NO: 56 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 253 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 56 8:

GGTGTTTGGC CACAGTTCGG GACCTATGGT AGAAAAATAC TCAGTAGCTA CCCAGATTGT 6 0

AATGGGTGGC GTTACTGGCT GGTGTGCAGG ATTTCTGTTC CAGAAAGTTG GAAAACTTGC 120

AGCAACTG CA GTAGGTGGTG GCTTTCTTCT TCTTCAGATT GCTAGTCATA GTGGCTATGT 180

GCAGATTGAC TGGAAGAGAG TTGAAAAAGA TGTAAATAAA G C AAAAAG AC AGATTAAGAA 24 0

ACGAGCTCTC GAG 2 53

(2) INFORMATION FOR SEQ ID NO: 56 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 544 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO; 569:

CACAGTG CTG GCTCACAACA AG ATGC TCAA GGTGTCAGCC GTACTGTGTG TGTGTGCAGC 6 0

CGCTTGGTGC AGTCAGTCTC TCGCAGCTGC CGCGGCGGTG GCTGCAGCCG GGGGGCGGTC 120

- GGACGGCGGT NATTTTCTGG ATGATAAACA ATGGCTCACC ACAATCTCTC AGTATGACAA 180

GGAAGTCGGA CAGTGGAACA AATTCCGAGA CGATGATTAT TTCCGCACTT GGAGTCCAGG 240

AAAACCCTTC GATCAGGCTT T AG ATCCAG C TAAGGATCCA TGCTTAAAGA TGAAATGTAG 3 00

TCGCCATAAA GTATGCATTG CTCAAGATTC TCAGACTGCA GTCTGCATTA GTCACCGGAG 36 0

GCTTACACAC AGGATGAAAG AAGCAGGAGT AGACCATAGG CAGTGGAGGG GTCCCATATT 420

ATCCACCTGC AAGCAGTGCC CAGTGGTCTA TCCCAGCCCT GTTTGTGGTT CAGATGGTCA 4 80

TACCTACTCT TTTCAGTGCA AACTAGAATA TCAGGCATGT GTCTTAGGAA AACAGAATCT 54 0

CGAG 544

(2) INFORMATION FOR SEQ ID NO: 570:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 330 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 570:

GAATTCGGCC TCATGGCCTA CATTAAAGAA AAGCTTCCCA CACATCCATT TGAAGCTGAT 60
CTCCTTGAGA TGGCAGAAAT GATTGCAGAA GATGAAGAGA AGAAG ACT CT ATCT CAGGGA 120

279

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GAGTCCCAAA CTTCTGAACA CGAACTCTTT CTAGACACCA AGATATTTGA AAAAGACCAA 180

GGAAGTACAT ACAGTGGTGA TCTTGAATCA GAGGCAGTAT CTACTCCACA TAGCTGGGAG 24 0

GAAGAGCTGA ATCACTATGC CTTAAAGTCA AATGCTGTGC AAGAGGCTGA TTCAGAATTG 300

AAGCAGTTCT CAAAAGGGGA AACCCTCGAG 33 0

(2) INFORMATION FOR SEQ ID NO: 571:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 312 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 571:

GAATTCGGCC TTCATGGCCT AAGGGAAAAC ATTTTGCATG TGTAAAGCTT CATGAAGTTC 60

TCTTTAAAAA ATACCAAAGC TTGTTTATTT CTGATAATTA ACCTAAGCCC TTATGAAAAT 120

AAACAAAATG AAGGGATTAT GACAGGTATT ACCAAAAACA CCAAAAGGAA CAAAGGGGCC 1B0

TGCGTTAAAA CCTAATTGCT AATGCTTCAC AACTAGGAGA GCATGCCGTC TTGATGTTTA 240

AAAAACCCAG GGTCTCCACC CTTCCTTTGA TTTGTGCAAT TCTGTCTTCC ACAGTTCCGG . 3 00

AGCTTACTCG AG 312

(2) INFORMATION FOR SEQ ID NO: 572:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:572:

GAAAATGTTC ATGGCCGCAG CAGGAGTAGA GGTCCTGAGC CTCCTATTTT TCTGCATCTA GO

CTGGGGTCAA TATGCCACCG ATGGCATTGG CAACGAGAGT GTGAAGATCT TGGCCAAGCT 120

GCTCTTCTCC TCCAGCTTCC TCATCTTCCT GCTGATGCTT ATCCTCCTGG GGAAGGGATT 180

CACGGTGACA CGGGGCCGCA TCAGCCACGC GGGCTCCGTG AAGTTGTCTG TCTACATGAC 24 0

CCTGTACACG CTCACCCATG TGGTGCTGCT CATCTACGAG GCGGAATTCT TTGACCCAGG 300

CCAGGTACTG TACACGTATG AGTCGCCGGC CGGCTACGGG CTCATTGGAC TGCAGGTGGC 360

GGCCTACGTG TGGTTCTGCT ATGCTCTCGA G 3 91

(2) INFORMATION FOR SEQ ID NO: 573:

(i) . SEQUENCE CHARACTERISTICS :

(A) LENGTH: 377 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:573:

GAATTCGGCT TCATGGCCTA AAAAAAACTC CAGAAAAAAA CAACAGCGCG GTGGTGGGGT 60
TTTG TTAATT TCGCCTTTTT TTTTTTTTGC ACGCGCCACG AAATT CAGGC TGCGTTTAGC 12 0

TCCTGAGAAA TATCCAAAGT AATTG CAG AT TGCGGAGACG CACAGCATTA GTTCAAAAAA 180

280

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GACCCGAGGC ATTGGGGCAG GGTTAGGTGG AGGGCACCGG AGGCTCTACA CAAGAAAAGC 24 0

AGGAACCTGC AAACCCACGT AGATTTCCAC TACAACCTTC CCTTTTCTTC TGGCTAGCCA 3 00

TCCAGCGCTC TCCATGGCAC TGCATGGCAC AAGTTGCTTC TGATAGTCTT TTAAGTTTGC 3 60

TAAGGGAACT CCTCGAG 3 77

(2) INFORMATION FOR SEQ ID NO: 574:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 325 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : ' double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:574:

GAATTCGGCC TTCATGGCCT ACAGCCTCAA GTCACTCCCA AGCCCCCTCC TTGTCTGTGC 60

ATCCGGGGGC AG CTCTGGAG GGGGTTTGCT GGGGAACTGG CGCCATCGCC GGGACTCCAG 120

AACCGCAGAA GCCTCCCCAG CTCACCCCTG GAGGACGGCC GGCTCTCTAT AGCACCAGGG 180

CTCACGTGGG AACCCCCCTC CCACCCTCGC GAGTCTGTTT CCAAGGAGGA GAAGGAGCAG 24 0

AACTATGACT TAACTGAAGT CTCAGAGAGC ATGAAAG CTT TCATATCCAA AGTCTCAACC 3 00

CACAAGGGAG CAGAGCTGCC TCGAG 3 25

(2) INFORMATION FOR SEQ ID NO: 575:

(i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 438 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 575:

GAATTCGGCC TTCATGGCCT ACTCAGCCTC CCTAATAGCT GGGATTACAA GCGTGAGCCA 60

CCACACCCCG CTGGGAAATA TCTTAAAAGA ATCAAAATAA GAAAGTTACT CTACTTAAAT 120

CGTGTGCTTT TTCTGTGTGT GATTTATGGT AATCTTACCA TGGGGTATCT GATTACTTTA 180

GAAAGATCCA TTTAGCTTAT TTTTTTCTTC TTTGGGTTAT TTTTTTCTTC CTTCCATTTG 240

CACAGCCTCC CCCCAAATAA AAAATAAAGA TATAAAGTCT ATCTTCTCCC TCTTGTCAGT 3 00

TTAAGTAAAA AGAACTTTTG CTTCCATTTT AATAATAGAA TTTGTGTGTA TATAATATAG 3 60

GCAGTGATTT GGCCTCAAGC TG AG TTTAG A TTTGAAAAGA TGAGAATATT AAAGCTTGTC 4 20

AGCCAGCCCA CTCTCGAG 43 8

(2) INFORMATION FOR SEQ ID NO:576:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 510 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 576:

GAATTCGGCC TTCATGGCCT ACTGTNTTCC ATAAAGGCTG TACTAATTTC CATTCTCACC 60
AACAGTTCAC TAGGGTTCCC TTTTCTCCAC ATTG TTGCCA ACATTCTTTA TCTTGTGTTT 120

281

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NTTAATAACA GCTATCCTAA CAGGTATGAG GTGATCTCTC TCATTGCGGT TTTGATTTGC 18 0

ATTTCCCTAA CGGTTGGTGA TACTGAGCAT TTTTGCATAC ACCGGGTCAT TTGTTCTTTG 24 0

TTGTTGACTT GAGTCCCTTA TATAGTTTGG ATACTGCTGT GGCCTGAATG TTTGTGTCCC 30 0

CCAAAAATTC GTATATTGAA CTCTCATCCC TAAGGTCAAC AGTTTAGGGA AGCGATTAGG 36 0

TCCTGAGGAC TCTGCCCTCT TGCATAGAAT TAGTGCTCTT ATAAAAGATG CCCGAGGGAG 42 0

CTCTTTTGCC CCTCCTGCCA TGTGAGGACA CAGCTAGAAG CTACCATCTG TGAACCAGGA 480

AGCCCCCCTC ACCAGACACT GTATCTCGAG 510

(2) INFORMATION FOR SEQ ID NO; 577:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:577 :

GAATTCGGCC TTCATGGCCT AAAAAATAAA AATAAAATAT ACAACCAAAG GCAGTATTCA 6 0

CAGAGGTATT TCTTGGGAAT AAAAGAAGGA ATATAGTCAT TCCTTGGTAT TCTCTTTGGT 120

GTCCAGAGTT ACTTAAAAAT TCTTGGTGTT TATTGCCTTT TAGTCACAGG GATACACCTT 180

TTATTCATTT ATTTATTTAT TTACCAGTCT CATTTAGCAG TAGGAATGCA TCTTAGCATT 24 0

TTTATACTGC TGCTCAACAC AGTGCTTTCA CTCGAG 276

(2) INFORMATION FOR SEQ ID NO: 57 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 262 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

{Xi) SEQUENCE DESCRIPTION: SEQ ID NO:578:

GAATTCGGCC TTCATGGCCT AAATCCTTCC AGATGTCCTG TGAAAATGTT TGAATGCTAC 6 0

TTGTCTAAAA GTCCACAGAA TCTTAATCAG AGGATGGATG TTTTTTATTT GCAACCAGAA 120

TGCTCTAGTT CTACAGATAG CCCTGTCTGG TATACGTCTA CTTCACTGGA CCGAAACACC 180

TTGGAAAATA TGCTTGTACG GGTTCTTCTA GTAAAAGATA TTTATGATAA AGACAATTAT 24 0

GAACTGGAGG AAGACACTCG AG 262

(2) INFORMATION FOR SEQ ID NO: 579:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 43 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 579:

GAATTCGGCC TTCATGGCCT AATTTAGGAC C AT TTAAG AG AGTTTGACTA AGAAAGAGCT 60
GTTTGAAACC TCCTGGCTTA TGTATTTTTA GGGGTGTGGT GATCGAGGCT TTCTCCTCTG 12 0

AGTAGAGTTT GTGCATTTGC AGTATAAGAT TATCATTATC AAACATTCCT ACTAGGCCTT 180

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TCTCCTCAGC CCCTAAAAAA ATATGTATAG TAATGAAGTA GGAAGATCAT GTTTATATTT 240

GACTTCACAA ATTCCTCAGG CTAAGTTGCT TTCTACTGGG GTGTGGCTGG AGACAAAAAT 3 00

TACAGGTAAG ACTTGACTTA ATTTTTGATA GGGAGGTTCT TAAGAGGCTT TTTCGGAATC 3 60

ACTCACCTCG CCCACTTCCA TGCAGGGATG TGGTGAGAGC CCTTCAGTCT ACTTAG GAAA 42 0

ACCTGGCACA TGACTCGAG 43 9

(2) INFORMATION FOR SEQ ID NO: 580:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 346 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 580:

GAATTCGGCC TTCATGGCCT AGATATTCTC AGGGTCATCA AGACTCCTGA GATAGCAAAC 6 0

TTGGCCTTGC TTGGCTTTGG AGATATCTTT GCCCTGCTGT TTGACAACCG CTACCTGTAC 120

ATCATGGACT TGCGGACAGA GAGCCTGATT AGTCGCTGGC CTCTGCCAGA GTACAGGAAA 18 0

TCAAAGAGAG GCTCAAGCTT CCTGGCAGGC GAAGCATCCT GGCTGAATGG ACTGGATGGG 24 0

CACAATGACA CGGGCTTGGT CTTTGCCACC AG CATG CCTG ACCACAGTAT TCACCTGGTG 300

TTGTGGAAGG AGCACGGCTG ACACCATGAG CCACCAGCCG CTCGAG 346

(2) INFORMATION FOR SEQ ID NO: 581:

<i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 740 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 581:

GAATTCGGCC TTCATGGCCT AGACCTGCCT CGAGATTGCC ATCTTGGTTT TGGTGGGTTT 60

CGGCCGACTT CTTTGCCACT TGCTATTTTA TTTTCTAGGT CTTTGTGCCC CGTATTGTGT 12 0

GCTGAACTCC NGTCTCATCC TGTGACTAAG ATTGCCTAAC CTCCTGGGAA TGCAGCCCAG 180

TAGATCTCAG CCTTACTTTA CCTAACCCCT TTTCAAGATG GAGTCACTCT GGTTCAAACA 24 0

CCTCTGACAT TCGCAGTGGA AT C CATTAAA AGATGTTAAG GAGATATGAT TATATTTCTA 3 00

AATTGTCACT CCAGCATCCC CTACGCCAGA CATTATGCCA GTCTCTATCC ATACAGTATC 360

TCATTTAATC CTCCCGTCAT TAATCTCATT TTACCAATGA GTAAACTTGA AGCAAATGAG 420

TGACTTTCTC AAGG CTACCT ACTTACGCCT TACCAGGGCC AGGATTCAAA CCTAGACTTG 4 80

TTCAGCGACA GAACACACAC TTAACCATCA CCCACTTAGG CCATGAAGGC CGGCCTTCAT 540

GGCCTAAACT. GCTGTTATTT TGGATTATAT GGAGTTATGA AAATCTAAAT GTTTTACAAA 600

GTTAAAAAGT ATTCTTTTTT TGCTCACTTA TAACTCAAAA AT CACTAAAG TCATTCTGCT 66 0

AAACATGCCA CGAAGCCAAG CTTCTTGCCA TATGTCTGCA TAATTTTATT AAATCACTGC 720

TATTGACGTG CAACCTCGAG 74 0

(2) INFORMATION FOR SEQ ID NO: 5 82:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

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(xi) SEQUENCE DESCRIPTION

SEQ ID NO: 582 :

GAATTCGGCT TTCATGGCCT ACAAAGGGGT
AGAGAGAGAG CAGGGAAAAC TGTCATTTAT
TGGTGGAGAA G AAAACTT C A GGAAGAGTGC
CTCCGTAGAG GCAGGGAGAG CAGCCAAGCT
AAGGTCTGGA ATCTTGTCAA GGAAGCAAGC
CTCCCAGGAC CCTGGGCAGC AACGGGTGCT
CTGGCAGCTA GAAGTCCTGG AGAATGACAA
TCAGCTCAGC AAGAGACTGC CACAGTTCGA
GAAAACT CGA G

AGCAAGGCAT GTCTTACATG GTGGCAGCAG
AAAACCATCA GATCAGTTGG GTTGTGCAAA
ATAGACTGAG CAGAGAAGAG GACCAGCTAC
GGAGCCTGAG C AG CAT TGC T GGACATGGAG
AAAGGGTTTC TTTCTATTCA ATGAAGTCCA
GGACTGGGCC ACCTGGCAGC GTCACATCAA
CTTCCAGGAC GACCCCCATG TGGGACTCCC
TGATGATGCA GACACCAGAC AGTAAAAGAA

SO
120
180
240
300
360
420
480
491

(2) INFORMATION FOR SEQ ID NO:583:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 566 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 58 3:

GAATTCGGCC AAAGAGGCCT AAACAGTCCA GAGAGG CATA AATCAGACCC AGTTCCTAGC 6 0

TGGCTTGTCC TTAT CAAGTA AATGGAAAAG GGGCCAGGCC AAAGCAGGGC AAGATGACCT 120

TGGACTTGGG AGAGACTTGG ACTCATGCCA CAATCCTAGG GTGCCCACTG GAC CATTGCT 180

TTTCTGAGTT TTGTAGTCAT TCGGTGTCTG AAGTAAGGTA GATTGAAGTG AGGCCTTCGG 24 0

TTTCCATCTG GACCCTTTCT CTCCTGTTTT CTTTTTTTCC GCCTTGTCCT AGGGATGTTC 3 00

AATAGCCCAG AAATGCAAGC CCTCCTCCAG CAGATCTCTG AGAACCCCCA GCTGATGCAG 360

AATGTGATCT CAGCACCCTA CATG CGCAG C ATGATGCAGA CGCTTGCCCA GAACCCCGAC 420

TTTGCTGCTC AGATGATGGT GAATGTGCCG CTCTTCGCGG GGAACCCCCA ACTGCAGGAG 4 80

CAGATCCGCC TGCAGCTCCC AGTCTTCCTG CAGCAGATGC AGAACCCAGA GTCACTCTCC 540

ATCCTTACCA ATCCCCATAC CTCGAG 566

(2) INFORMATION FOR SEQ ID NO: 584 :

(X) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 82 base pairs
IB) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

Ui) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 584:

GAATTCGGCC TTCATGGCCT AGTTGAAAAT GATCATTACA CAATATATTC CTAAACATAA 60

ACTGAGTAAA CTTGAAACAG CTCACTGTGT GGAGAGGACC ATTCCCGTTT TGCTCACCAG 12 0

AACTGGAGAT TCTTCTGCCC GCCTCCGCGT CACAGCTGCA AATTTTATTC AGGAAATGGC 180

CTTGTTTAAA GAAGTTAAGT CTCTCCAAAT TATTCCATCC TACCTGGTGC AGCCATTGAA 24 0

AGCAAACTCT TCAGTTCACC TGGCAATGAG TCAGATGGGC CTCCTGGCCC GGCTGCTGAA 3 00

AGACCTGGGC ACTGGCAGCT CGGGCTTCAC CATTGACAAC GTGATGAAGT TTTCAGTGAG 3 60

TGCCCTGGAG CATAGAGTGT ATGAGGTCCG CGAGACGGCG GTTCGAATTA TTTTGGACAT 420

GTACAGACAG CACCAGGCTT CCATCCTGGA GTACCTTCCT CCAGACGACA GCTAATCTCG 48 0

AG 482

(2) INFORMATION FOR SEQ ID NO: 5 85:

284

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 5 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 58 5;

GAATTCGGCC AAAGAGGCCT AATAAAGGTG TGGAAACTTC ATTCATTCAT ATCTTCAACA 60

CAAATTGTAG GTAGCCTGTT TTTTAAAACA TTTATTCAAC AAATATTTAG TCCAAGCCAC 12 0

TATTACTTAC TACCTTCTCT ACTATTGTAT GGACTTTTAA CTATCTCTGA CACTATTCAC 180

TATTCTTCCA CATTCTCTAT TATTTATACC TATGGTAAAA TTTGCCAGTT TGACCATACA 24 0

ACTAATACTC ACAGGGACAC TCGAG 265

(2) INFORMATION FOR SEQ ID NO: 586:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 120 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 586:

GAATTCGGCC AAAGAGGCCT ACTCGAGTTT GGTGCTTTAT TTAGCAAGTG AGTAAAAATA 6 0

TTGGAATATT TAAGTATTTG CATAAAAAAT CAAATGGTAG TGTTTTGTAA TCTCTACTGT 120

(25 INFORMATION FOR SEQ ID NO: 587:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 503 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 58 7:

GAATTCGGCC AAAGAGGCCT ACTCGAGTCA GGTCTAGAAT TCAATCGACG GTTTAGGAAA 6 0

AAGACAATTT AAGAGAAGAA CTAAAGAAAA GAACAGAAAC TGAGAAGCAG CATATGAACA 120

CAATTAAACA GTTAGAATCA AGAATAGAAG AACTTAATAA AGAAGTTAAA GCTTCCAGAG 180

ATCAACTAAT AGCTCAAGAC GTTACAGCTA AAAATGCAGT TCAGCAGTTA CACAAAGAGA 240

TGGCCCAACG GATGGAACAG G C CAACAAG A AATGTGAAGA GGCACGCCAA GAAAAAGAAG 3 00

CAATGGTAAT GAAATATGTA AG AGG TGAGA AG GAATCTTT AGATCTT CGA AAGGAAAAAG 36 0

AGACACTTGA GAAAAAACTT AGAGATGCAA ATAAGGAACT TGAGAAAAAC ACTAACAAAA 420

TTAAGCAGCT TTCTCAGGAG AAAGGACGGT TGCACCAGCT GTATGAAACT AAGGAAGGCG 4 80

AAACGACTAG ACTCACTCTC GAG 50 3

(2) INFORMATION FOR SEQ ID NO: 588:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 567 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

285

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<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 588:

GCCACTATGG TACCAAAACC TCAGTCTTCA
CCCACAAACA TTCTTATCCT CATCCCAGCA
ACTCAAGCGC TAATGCTGGG AAGGACCTCT
CCAGGGTCAC CAAAGCCTGT TAATGCTACC
TCAAAACCCA GCCACATAGT AAGTTCAAGG
GCCCTATAAC AGTAAACTAT TCACTTCCCC
CCTGTACTGC CAAGGGAATT ACTTTTCTAA
ACTGTCCCAA AAATAAATTT TAATTCCTTC
GTTTGGTCTA GTGTCCTTTT AAAGACACTA
ATACGACTTA TCAATTCCCT ACTCGAG

CATAG TC AAA CTTGGACACA AACAGCACCT
TTGGTTACTG ACCACACACT CTAGCAGGTC
GAATACTTCT CTTTGTCTTG TGCCACACAG
TCCAAAAAAG GCAAATCTGA CCCCTCTTCC
ATTCAGTCAC AGGTCTGCCT TAGTGCACTA
TCCAGTCCCT TGCCCCCTTT CAAGCAATTT
AATTAG CTAA GAAACTTTTG ATGGTATCTT
TTTAGCATGG TATAAAAAGG ACACAACAGA
GATTTCTCAT CACCATACCG CATGTACCCT

60
120
180
240
300
360
420
480
540
567

(2) INFORMATION FOR SEQ ID NO: 58 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 8 base pairs

(B) TYPE: nucleic acid

(C) STRAND EDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:589:

GAATTCGGCC AAAGAGGCCT AGGCATGGTG AGTTTTGATC TTCTTCCCCT TCTTTTCTTC 6 0

CCCTTCTTCT TTCCTTCTTT GATCTTCTTC CCCTTCTTTT CTTCCCCTTC CCCTTCTTTT 120
CAATTTCTCC CACGTCAA 138

(2) INFORMATION FOR SEQ ID NO: 590:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 590:

GAATTCGGCC- AAAGAGGCCT AGAGAGAATG GAAAAGATAA GGAACAGAAA CAAACAAATA 60

CCGATAAAGA AAAAAATAAA AGAGAAAGGG AGCTTCTCTG ACACAGGCTT GGGTGATGGA 120

AAAATGAAAT CTGATTCTTT TGCTCCCAAA ACTGATTCTG AGAAGCCTTT TCGGGGCAGT 180

CAGTCTCCCA AAAGGTATAA GCTCCGAGAT GACTTTGAGA AGAAGATGGC TGACTTCCAC 240

AAGGAGGAGA TGGATGATCA AGATAAGGAC AAAG CTAAGG GAAGAAAGGA ATCTG AG TTT 3 00

GATGATGAAC CCAAATTTAT GTCTAAAGTC ATAGGTGCAA ACAAAAACCA GGAGGAGGAG 3 60

AAGTCAGGCA AATGGGAGGG CCTGGTATAT GCACCTCCAG GAAAGGAAAA ACCGAGG CAG 4 20

(2) INFORMATION FOR SEQ ID NO: 591:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 611 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

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(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION -.

SEQ ID NO-.S91:

GAATTCGGCC AAAGAGGCCT ACATTGCTTT
CATGTGGCTA CTTTAGTAAT ATTGCCAAGA
AGTGAAATTA ACCAAAGATG AAGCTTTGGC
AGGCAGCGCC ACTCCAGGGT TCAGACAGGG
GGGCTGAGAC GCCATGGGGC CGCTGCTGCT
ATTAAAACTG AAGGCATTTT TTTTTTTCTG
AAGAGATGAT GATGGTAATA TTTATTTGTG
GCATGCTTGT TTTCAGTATA CCGTGGCCTG
GATGTGAGGT GGGGACTTCA TTCATTGTCC
CTTTCAGGGG AGGTGGAGGA GGAGGGTCTG
NACCCAGACC T

TCAAATAACT TAAAATAACA CGTTATGTGC
AGAGCACAGT TTTTACACTA GTGGCATCTC
TTTGCTGGTG AG ATCAGAG C CCTCCTGAGC
CTGCACAGGC GGCAGAGATA CAGGGTCTGA
TATGTGGTTG GATTGTTTAC AAGCCTCATT
CTGCCTTTCC CAAAGTGGTT AGGTTTGGAA
CTTTTTAAGC CATTTCCCCA AATGGGACTA
CCTCATGATG GTTTGGAGAT ACTGTCTGTG
TATTTCTATC TNCACTTTGT GCCTGGAGAG
CCAAGCTACT G CAAC ATCTG TCACCCACTA

60
120
180
240
300
360
420
480
540
600
611

(2) INFORMATION FOR SEQ ID NO: 592:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 443 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 592:

GAATTCGGCC AAAGAGGCCT AATTGAATTC TAGACCTGCC TGAAACCTGT CCCTCCTAGG 60

AAATTGAATA GCTTGAGTTA CGAAGGAACT GCATGGGACA GACTGAGTTT TGTTCCTCTC 120

TTCCCTGGAA GCTGGATGTC CTTTACAGCT TTGCCCAGTA TGT CATGTGG CCCCTGAAGT 180

ACATAATCCA GAGTGGACTG CCTTTCAGGG TCCCTCAGCT GTGAAAGTGG AGCATTCATA 240

TCAAGACTAC ATCTTTCCTG TTCAGCTTTC TTCAGCCTTG GAGGAACCAC ACACAATGGA 3 00

TCCAAGACTT CTGTCCCTTG CTAATTATCT ATAAGAAGTA AACCCATTTC ACATAACTTG 3 60

TGAATATGTT TTCTTTCACT GGATTTTGGC AAATAGGTAC CCAGTGCATG GTGGACCTAC 4 20

ACAGTTAGGC CTCTTTGGCC GAA 443

(2) INFORMATION FOR SEQ ID NO:593:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 593:

GAATTCGGCC AAAGAGGCCT AAAAGCATTC AG TATTGGTA AAATGAGTAC AGCTAANCGA 60

ACTTTAAGTN AAAAGGAGCA GGAAGAATTA AAGAAAAAGG AGGATGAAAA GGCAGCTGCT 120

GAGATTTATG AGGAGTTTCT TGCTGCTTTT GAAGGAAGTG ATGGTAATAA AGTGAAAACA 180

TTTGTGCGAG GGGGTGTTGT TAATGCAGCT AAAGAAGAAC ATGAAACAGA TGAAAAAAGA 24 0

GGTAAAATCT ATAAGCCATC TTCAAGATTT GCAGATCAAA AAAATCCTCC AAATCAGTCT 3 00

TCCAATGAAA GACCACCATC TCTTCTTGTG ATAGAAACCA AAAAACCTCC ACTTAAAAAA 3 60

GGAGAGAAAG AAAAGAAAAA AAGCAATTTG GAACTCTTCA AAGAAGAATT AAAGCAAATT 42 0

CAAGAGGAAC GTCGACTCGA G 441

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(2) INFORMATION FOR SEQ ID NO: 594:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 562 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO:594:

GAATTCGGCC AAAGAGGCCT AAGAAAACCT AGCTAATAAA GAAAAAGCTG TTGCTCAAAT 60

GAAGATAATG ATCTCAGAGT GTGAATCATC TGTGAACCAG CTGAAAGAAA CATTGGTTAA 12 0

TCGAGATCGT GAGATAAACA GCCTCCGGCG CCAGCTTGAT GCAGCTCACA AAGAACTCGA 1B0

TGAAGTAGGA AGATCTAGAG AAATCGCTTT TAAGGAAAAC AGAAGACTGC AAGATGACCT 24 0

GGCTACAATG GCAAGAGAAA ATCAAGAAAT CTCATTGGAA TTGGAAGCAG CAGTGCAAGA 300

AAAAGAAGAA ATGAAGAGCA GAGTTCATAA ATACATAACA GAGGTGTCAC GATGGGAGAG 3 60

CTTAATGGCT GCCAAGGAAA AAGAAAATCA AGATTTGTTA GATAGATTTC AGATGCTTCA 4 20

TAACCGTGCT GAAGACTGGG AGGTCAAAGC CCATCAAGCT GAGGGAGAAA GCAGCTCAGT 4 80

TCGACTGGAA CTTCTTTCTA TTGACACTGA GAGGAGACAT CTTCGGGAAA GAGTGGAGCT 54 0

ATTAGAAAAA GAAAATCTCG AG 562

(2) INFORMATION FOR SEQ ID NO: 595:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 426 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 595:

GGAAGAGCAG AATTTGGTGG CTTATCCTCA TGATGGAAAA ATCTTTTTCT GCACCTCACA 6 0

AGATATCCCT CCTGAAAATG AACTGCTTTT TTATTATAGC CGAGATTATG CTCAACAGAT 12 0

TGGTGTTCCT GAACACCCAG ATGTGCATCT CTGTAACTGT GGCAAGGAGT GCAATTCTTA 18 0

CACAGAGTTC AAAGCCCATC TGACCAGCCA CATCCATAAC CATCTTCCTA CCCAGGGACA 24 0

TAGCGGCAGC CATGGGCCAA GTCACAGCAA AGAAAGGAAG TGGAAGTGCT CAATGTGCCC 3 00

CCAAGCTTTT ATCTCTCCTT CCAAACTTCA TGTCCACTTT ATGGGTCACA TGGGTATGAA 3 60

GCCCCACAAG TGTGATTTCT GTAG CAAGGC TTTTAGTGAT CCCAGCAACC TGCGAACCCA 42 0

CTCGAG 426

(2) INFORMATION FOR SEQ ID NO: 5 96:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5 96:

GAAAAATCAG TCGACTGAAT GACACCATCA AATCTTTGAA ACAACAGAAG AAACAAGTGG 60
AACATCAG CT GGAAGAAGAA AAGAAAGCAA ACAATGAGAA AC AG AAAG CT GAAAGGGAGC 120
TAGAGGGTCA AATCCAGAGA TTGAACACAG AGAAAAAGAA ACTAAATACG GACCTGTATC 180

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ACATGAAACA TTCTCTCAGA TACTTTGAAG AAGAGTCCAA GGATCTGGCC GGCCGCCTGC 24 0

AACGTTCATC GCAGCGTATA GGAGAGTTAG AGTGGTCTCT CTGTGCTGTC GCCGCCACAC 3 00

AGAAGAAGAA GCCGGATGGG TTCTCGAG 3 28

(2) INFORMATION FOR SEQ ID NO : 5 9 7 -.

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 529 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 59 7:

GAGAAGTGCG AGAGGGGCCA GTGTTGTTGT TAC CTGAAAG GTAAGTGCAG CCCACAAAAA 60

TGCAGTGAAG AAGAAGATAT ATG CAT ATGT TTAAGTTAAT ACAATTGAGA TACATTTAGC 120

AGACAGAATC AATAGAGTTG ATGAGTGACT GACTGGATGT GTGGGGAGTT TATATCACTC 180

CCAGGTTTTT GACTTGGGCC ACCGGGCACT CAAGAAGGAA AAAGAGGATC CAGGGAGAGG 240

AACTTTTCTG AGGACTGGGG TAGGGCTGAA CAGCTGCATT CGAGACTGGT GGAGGGTGGG 300

CTGGGCATGG GATGCACAAA TGGAAATTCC ACTGGGTCTG CAGCTCACAC ATAGG CATGA 360

CCAG CAT AGA GATAGAGAGG CCCCAGTGCT GCTGAGTAAC TGTGATTCCC CAGGTGATGG 420

CATCAGCTGA GAAGGGAAGG AAGCCCATGT GAGGACACTG AAGAAGGAGT GAGCAGACAA 480

TAAGAAGCCC ACAGAAGACA GAGAAGGAAC AACTAGAAGG AGGCTCGAG 529

(2) INFORMATION FOR SEQ ID NO: 598:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 54 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION t SEQ ID NO:598:

GAAAAAGATG AAATCTGATG GATTAGGAGC ATCTGGACAT TCGTCAAGTA CCAATAGAAA 6 0

TAGTATAAAT AAAACTCTGA AGCAAGATGA TGTAAAGGAA AAAGATGGTA CAAAAATAGC 120

ATCTAAGATT ACAAAAGAAC TTAAAACTGG GGGAAAAAAT GTTTCTGGAA AGCCCAAAAC 18 0

TGTAACAAAA TCCAAAACAG AAAATGGTGA TAAGG CACGG TTGGAAAACA TGTCACCTAG 24 0

ACAAGTTGTA GAAAGATCAG CAACAGCAGC AGCAGCAGCA ACTGGACAGA AGAATTTACT 300

AAATGGAAAA GGAGTGAGAA ATCAGGAAGG GCAAATTTCA GGTGCCAGAC CCAAGGTACT 360

CACAGGAAAC TTAAATGTGC AAGCCAAAGC AAAGCCTTTG AAGAAAGCTA CAGGGAAGGA 420

TTCACCATGC CTCAGCATCG CAGAACCCCT CGAG 4 54

(2) INFORMATION FOR SEQ ID NO: 599:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 411 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 599:

289

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GAATTCGGCC TTCATGGCCT AGGTCCTCAA GCATTGCTTC AATATCAATA TCGTCTGCCA 6 0

TTTTCTCTAA ACGCCTGTTC CGGCCTTCGG GCGCCTGTGG TGCTCGTGTT CGGGAAGAGA 120

TTGCTGCTGC TGCTGCTGCT GCTGCCGCCG CCGCCGCTTC TGTTGCTACT GTTAAGCCCC 18 0

TAGGCCCAGG CCGCGGAACC GCCCAGCCCG AATATCGGGT TCCAAGGACG GCTAGGCCCG 24 0

AGAGAATCTA AAAAAAACAA TGGAATTAGA GAAGCCCACG CGGGAGAGCA GGACGGCGGC 3 00

TTCGGCAGCT CAGGATCCAC CCCNGCGACA GCGTCGACAA GTTCCCTGAA ATGGCGGCCG 3 60

CTGCTTCCCT GTACTCANAN TCCACCCCCC GAATTCTAGA CCTGCCTCGA G 411

(2) INFORMATION FOR SEQ ID NO: 60 0;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 306 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 600:

GAATTCGGCC TTCATGGCCT AATTAAGCCT GCCTACTTCT ACAATG CATT CTGTTACCTA 60

TTTGAACAGT ATGTTTGTAA CTATGGCAAT GAAGTCAGTA GATAGGAAAC CAGTTATTCC 12 0

TTCTACCTTT AAAAATTTTG AGAACTTGCC AACCAGGGAC TAAAGCTATT ATCTTGAACA 180

GAGTCCCTAA AGCTAGTCTA GTTTTTGCCA CATCTGCAAT GATTATTGTT TAATTTCAAA 24 0

AGAATCCTCA GGCTCTACAA TCTAGGGGTG GTAAATGTGT TTCCACTATA CTTGGGACCG 3 00

CTCGAG 3 06

(2) INFORMATION FOR SEQ ID NO: 601;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 443 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 01:

GAATTCGGCC TTCATGGCCT AGGAATCTCC TCTTAAACCA GGTGAAGTGG GAAAGCAGGG 60

ACCATACCAC CCTGAGTGAC ATCTACCTGA ATAATATCAT TCCTCGATTT GTACAAGTCA 120

GCGAGGACTC AGGAAGACTC TTTAAAAAGA GTAAAGAAGT CGGCCAGCAG CTCCAAGATG 180

ATTTGATGAA GGTCCTGAAC GAGCTCTACT CGGTCATGAA GACATATCAC ATGTACAATG 240

CCG ACAG CAT CAGTGCTCAG AGCAAACTAA AGGAGGCGGA GAAGCAGGAG GAGAAGCAAA 300

TTGGTAAATC GGTAAAGCAG GAGGACCGGC AGACCCCATG CTCCCCTGAC TCCACGGCCA 3 60

ACGTTCGCAT TGAGGAGAAA CATGTCCGGA GGAGCTCAGT GAAGAAGATT GAGAAGATGA 420

AGGAGAAGCA CCAAGCCCTC GAG 443

(2) INFORMATION FOR SEQ ID NO:602:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 585 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:602:

290

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GAATTCGGCT TCATGGCCTA CAACATGTCA GTTTTTTTTT
CTTCTNGCTT TCTCTTCTCC TGGTTCCCAG CCTCTACTCA
TGCTGGTCTC GGGGCTTCAT GGAGATGAAT GGGCGGGGGG
AGATTCTGTG CTTCCACGAG GCTTCCCCCC ACTCCTCTGC
GCCACCAATG GCCGGGAGGG GCTCCTGCGC TTCAGTTCCT
GTGGTACAAC CTCTTACCCT GCAAGTTCAG AGACCCCTGG
GCCTCCTGGG TCTCAGAACT GCTGTGGTCA CTTTTCGTCC
AGGTGGCTTC GTCCTGTTCA TCGCCAACTA GGGGAAGCGA
GTACAACAGC TGGTGGCCAA GGAATTGGGC CAGACAGGGA
AAAGCAGAGC ACATGAAGCG ACAAAGACAC CCCACACATC

TCATTTTCCT CAATATTTTT
ATAGTCCCCC CAGCTTTGTG
AGTTGGTGGA GTCACTCAAG
TGCTATTCCC TGAGGAAGAG
GGCCATTTTC TATCCAAGAT
TCTCTGTGAC GGTGTCAGAT
CTTTCACGGT GTAT CAAGTA
ATGAGGAGTT TGCACTCCGT
CACGGCTCAC TCCAGCTGAC
TCGAG

60
120
180
240
300
360
420
480
540
585

(2) INFORMATION FOR SEQ ID NO: 6 03:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 68 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:603:

GAATTCGGCC TTCATGGCCT AG TCTGGTAG TAAGGTGGAG TGGGTTTGGG GCTAGGTTTA 60

GCTCGGGGGA GGTGGTGTTG GGGGCCGCAG GCTGCGCGGT GCCTGGGTAC ATCTCCAGGC 120

CCACGCCCCG GGCTTGGGAA GTCACATCCA TGTCTCTGCG CCGTGCAGCT TTCAAGATTT 180

GCCGAAAGGC TCCCAGAGCT CTGTTTTAAA TGGTGAATCC ATCTTTAGAA AGAAGCGTGA 240

TTCTCCTTGA AGTGAGCCTG GCATTTGTCA GACAGGAAAC TCCCCAGGAG GAG CACCTGT 3 00

GGTGGTTTGG GTTGGGTTTG TTAACTGCAG AGAGTGGGAA GAACAGATGC TCCTCACACC 3 60

GTCTCGAG 368

(2) INFORMATION FOR SEQ ID NO: 604:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 604 base pairs

(B ) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 04:

GAATTCGGCC TTCATGGCCT AGGAAAGACC ATCAGCCTGG GAGTCAGTGA ACCTGACTCT 60

GATCCCAGCT CTGCCTCCAN TCAGCTGTGT GATGACAGGT AGGTCACCTT CCCTCTCTGA 120

GCCACAGTTT ATCTGTCTGT AAACAGGGGT ATTGGACTGG ATTCTCTGTT ATCTCTCATG 18 0

TCTCTGTGAA AGGTCTGTGT TTTCAAATAC TCCTTAGGGA CATGACCTCA CATAGAAAGA 24 0

GGGGGTGCCA CGAACTGGAT TCCCAGCACT CCCCCTTCCC AGCTCTGCTC AAGCTGAGGG 300

ACCTTGGAAC ATGGTACTTG GACCTAAGTA CTCTCTCTGG GCTTCAGTGT CCCCAGCTAT 3 60

AAAATGGGGG AAATGCCTAA CTCAGGAGGT TGAGGTAAGG ACAAAAGGAA TTAATACATG 420

GAAAGTGCCT GGAACAGTGC CTGGCACAGT CTGCTTTCAG AAAAAGCTGC AAGGTGGCTA 4 B0

CTCTCAGCAG ATATAAGTTA ATGCAGGAAC AGCAACTAGC AGCTCTTGGA CATGCAATAT 540

ATTATATATT TTTTGCATCT TTTACCCTTC ACGGCACTGA GCCTCACAAT CCGTTGACCT 600

CGAG 604

(2) INFORMATION FOR SEQ ID NO: 605:

(i) SEQUENCE CHARACTERISTICS :

(A> LENGTH: 4 95 base pairs
(B) TYPE: nucleic acid

291

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(CJ STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii)

MOLECULE TYPE; cDNA

(xi)

SEQUENCE DESCRIPTION: SEQ ID NO: 6 05:

GCGCAGCCAG
GCAGGAAAGG
CCAATCGACT
TATAAGTAGA
TGTGAACTCT
CCCACAGCGG
CGGGCCGCCA
CACAGGGACA
AAGGAGCGAC

CGCCTGCCTC CGACTCGACT CCACACCTGC TTGCTACAGC GGGTGAGGAA
GGGAGGGAGG GATGTCGTCT GGATTCCTGT AATAATTTGT TTCATTGTTT
TAGTCACCAG GTTAAATAGT AG CAT AG ACC TTTCAAAAAA GTAGCTAGCT
TGTATTGAAA ACACCTGCTT GTTGAGTCGT AGACAATTCC TCATTTACTG
AGGGGGTGAA ACACGGGCGG AGAGCGGCTG TGAGCTCACG CGGCTCCATC
CCCAGGGTCA CTCGGGGCCA TTAATCAGGC CGCAGAGCTG CCCTCTGAGC
GCGCCCACAG GGCCCAGACC AGGGCTCCCT GGGCGGGATG TTTTAAATCG
AAGGAAAGGA AAGACGCTGG GGCCCAAGCC CGAGCTTATG AAACG TTATC
TCGAG

60
120
180
240
300
360
420
480
495

(2) INFORMATION FOR SEQ ID NO: 606:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 331 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 06:

GAATTCGGCT TCATGGCCTA GACTTCCAAG GACATGCTTC GAACTCTGGC CCAAGCCAAG 6 0

AAGGAATGCT GGGATCGGTT CCTCCAGGAG AAGTTAG CTT CAGAGTTCTT TGTGGATGGA 12 0

CTTGATTCTG ATGAGAGGTG ACTACAATTG CAAAGTAGAA TTTGCTTTGA CACCTGATGC 180

CAGGACAATA GTATGTTACC ATCCTTCTAT AGACATTCCA TATGAACGCA CAAAACCTAT 240

CCCTTGACCA GATCCTGTGT ATAATAATGA AGAAACACAT GGTCAAGTGC TGAAAACTAG 3 00

AGAAGAAAAA AGTGAACACC TGGAGCTCGA G 3 31

(2) INFORMATION FOR SEQ ID NO: 607:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 2 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi.) SEQUENCE DESCRIPTION: SEQ ID NO: 607:

GAATTCGGCC TTCATGGCCT ACTGCCTCGG CCTCCCGAGT AGCTGGGACC ACAGACGCCC 60

ACCACCATGC CCGGCTAAAT TTTTGTATTT TTAGTAGAGA CGGGTTTCAC CGTGTTAGCC 120

AGGATGGTCT CGTTCTCCCG ACCTCGTGAT CCGCCCGCCT CGGCCTCCCA AAGTGCTGGG 180

ATTACAGGCG TGAGCCAACT CGCCCGGCCA GGAATCCCTC CTCTGTCTGA CCTAACTGCC 240

CTCTGCCCTG GAGCTGCTCA GCCTCTATCA ATTTTTCTGG CTCTCAGCGA ACGTTTTCAT 3 00

TCAGTTGCAA GACACAGAAA CTCAAATTCA AACCTGCTTA CACAAAATAG TGAATGTACT 3 60

GGCTCATGCA CTTTTTAAAG AGATGAGGTC TGTTGTGCTG CCCAGGCTGG ATGTGAACTC 420

CCGGGCCCAA GAAATTCTCC TGCCTCAGTC TCCTGAGTAG CTGGGACCAC AGGAGCATGA 4 80

CTGTAAGTCC TGGTGTGAAT CAGGCTCCAG AAACAGCTTG ATCCTGGTTC CCAACAGTAT 54 0

GGTCAAAACT CATTCTCTCT TCTGTCTTCT TCTCTATGAC AGGTGCTCCC TAAGAAGTGA 600

CAAAGAAGGC CACTAACAGC TCTGGGCTCG AG 632

292

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(2) INFORMATION FOR SEQ ID NO: 608:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 531 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 608:

GTATNGNTGA AAATAAGAAA AAATATTTCT GAAATTCGGG AACTTGAGAA CATAGAAGAA 60

CACCAGTCTG TAGATATTGC AACTTTGGAA GATGAAGCTC AGGAAAATAA AAGCAAAATG 120

AAAATGGTTG AGGAACATAT GGAGCAACAA AAAGAAAATA TGGAGCATCT TAAAAGTCTG 180

AAAATAGAAG CAGAAAATAA GTATGATGCA ATTAAATTCA AAATTAATCA ACTAT CGGAG 24 0

CTAGCAGACC CACTTAAGGA TGAATTAAAC CTTGCTGATT CTGAAGTGGA TAACCAAAAA 300

CGAGGGAAAC GACATTATGm AGAAAAACAA AAAGAACACT TGGATACCTT AAATAAAAAG 360

AAACGAGAAC TGGATATGAA AGAGAAAGAA CTAGAGGAGA AAATGTCACA AGCAAGACAA 420

ATCTGCCCAG AGCGTATAGA AGTAGAAAAA TCTGCATCAA TTTTGGACAA AGAAATTAAT 4 80

CG AT TAAGGC AGAAGATACA GGTAGAACAT GCTAGTCAAG GAGACCTCGA G 531

(2) INFORMATION FOR SEQ ID NO: 609:

(i) SEQUENCE CHARACTERISTICS :

(A> LENGTH: 33 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 609:

GTGACTTTGG AACCTTGAGA GTTAGATGAA TAAATCAGAA AAATGGAATT AAATGTATCT 60

ACTTTATTAT TGGTAAATCT GGTTAGGATG TGCAGCCCTA ATCAGGCTTC CTTAATTCCT 120

TCTCCACTGA GTCTGGACCA GCACTCTCCA GTAGAACTTT CTATGATGAC GGAAATCCTC 180

TGTGTCTGCG CTGATCAGTG TGGTAGTTAC TGGCCACATG TGGCTGTTGA GTACTTGAAA 240

TGTGGCCAGT GTGGTGATGG AATTGTGTTT TTAATCTTAT TTAATTTAAA TTTAAATAGC 3 00

CAAATGTGGC TAGTGGCTGT TGTACTCGAG 330

(2) INFORMATION FOR SEQ ID NO: 610:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 45 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 610:

GTGGAGGCTT TCTTGATCAT GGATGGTGAA GATATACCAG ATTTTTCAAG TTTAAAGGAG 60

GAAACTGCTT ATTGGAAGGA ACTTTCCTTG AAGTATAAGC AAAGCTTCCA GGAAGCTCGG 120

GATGAGCTAG TTGAATTCCA GGAAGGAAGC AGAGAATTAG AAGCAGAGTT GGAGG CACAA 180

TTAGTACAGG CTGAACAAAG AAATAGAGAC TTGCAGGCTG ATAACCAAAG ACTGAAATAT 240

GAAGTGGAGG CATTAAAGGA GAAGCTAGAG CATCAATATG CACAGAGCTA TAAGCAGGTC 3 00

TCAGTGTTAG AAGATGATTT AAGTCAGACT CGGGCCGAAC TCGAG 345

293

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(2) INFORMATION FOR SEQ ID NO: 611:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 611:

GAATTCGGCC TTCATGGCCT AAATG AC CAN ATCGAGAGGG AGGACTATGA GGACTTTGAG 60

TACATTCGGC GCCAGAAGCA ACCCAGGCCA CCCCCAAGCA GAAGGAGGAG GCCCGAGCGG 12 0

GTCTGGCCAG AGCCCCCTGA GGAGAAGGCC CCGGCCCCAG CCCCGGAAGA GAGGATTGAG 180

CCTCCTGTGA ACCTCTGCTG CCCCCGCTGC CCCCTGACTA TGGTGATGGT TACGTGATCC 240

CCAACTACGA TGACATGGAC TATTACTTTG GGCCTCCTCC GCCCCAGAAG CCCGATGCTG 300

AGCGCCAGAC GGACGAAGAG AAGGAGGAGC TGAAGAAACC CAAAAAGGAG GACAGCAGCC 360

CCAAGGAGGA GACCGACAAG TGGGCAGTGG AGAAGGG CAA GGACCACAAA GAGCCCCGAA 420

AGGGCGAGGA GTTGGAGGAG GAGTGGACGC CTACGGAGAA AGTCAAGTGT CCCCCCATTG 4 80

GGATGGAGTC ACACCGTATT GAGGACAACC AG AT C CG AG C CTCCTCCATG CTGCGCCACG 54 0

GCCTGGGGGC ACAGCGCGGC CGGCTCAACA TGCAGACCGG TG CCACTG AG GACGACTACT 6 00

ATGATGGTGC GTGGTGTGCC GAGGTCACTC GAG 633

(2) INFORMATION FOR SEQ ID NO: 612:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 296 base pairs

(8) TYPE: nucleic acid

<C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:612:

AAATACTAGA GATAAAGTAG ATTCATGGCT TGGTAAGGAA ATTTTAAGCA TTCCTTCAAA 60

GATTGACGTG CTAAAATAAG CATTGATGTT TTGAGTTTTT TTACACCTAG GATTTTTAGC 120

TTGGGTGTGT AGGTGAAGGC CAAGACTCTC TGCAGGAAAA AGCTTATTTT CAAACTCAGA 180

AAATAAAATG TCAATCATAA AAATCTACTT CAACT TTAGC AAAAAGAAAA AAAAAATCAA 24 0

CAAAAAGTAT ACTCTGTATG CTGGGATTCC GAGGTTCCAA CACACTGTTA CTCGAG 296

(2) INFORMATION FOR SEQ ID NO: 613:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 613:

GATCCAGTGC TGCAGCTTCC TTACTATGAA ATGACAGCTC CACTTCCTAA TAGTGCATCC 60

GTGTCTTCCT CACTGAATCA TGTT C CAGAT CTTGAGGCTG GACCCAGCTC ATATAAATGG 12 0

ACTCACCAAC AACCAAGTGA CTCTGACCTT TAT CAGATG A CAGCTCCACT TCCTAATAGT 18 0

GCATCCGTGT CTTCCTCACT GAATCATGTT CCAGATCTTG AGGCTGGACC CAG CTCATAT 24 0

ATAATGGACT CGCCAACAAC CCCTCGAG 268

294

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(2) INFORMATION FOR SEQ ID NO:614:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 272 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 14:

GGTGGAAACT AT CCAAGAGG CCTTCTGAAT TCCTCTGACA TATATTTGAG AAACTGGGCT 60

ACTGAAAGCC CTAACCCCAC TTGGCTGCAT TTTATTTGGT AACCAGTGAG GCAAACACCC 12 0

TTGCCAGACC CCTACCATCC ATCTTGATGT GGTTCCTGCA CTGGACACTG CTTGGGTACG 180

GGCCTGCCCA GATCTTGGGA ATGTGGGCAG TGGCTCCTCT GAAGCACCAG TGGGCAGAGG 24 0

ATGAGTCATG GTATCCTCCC GGCACCCTCG AG 272

(2) INFORMATION FOR SEQ ID NO: 615:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 521 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 15:

(2> INFORMATION FOR SEQ ID NO: 616:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 577 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 616:

GAATTCGGCC TTCATGGCCT AG AT TGGAAG GTGTGGTAGG CAGAATTCTG GCCCCCATGA 60

CTGCCCCTTC CCCTCACACC CCCCGGGTTG CTCCAATGGT TATGTCACGT TGCTTGGCAA 12 0

AAGGGACTTT GTAGATGT CA TAAAAGGTGA CTAATCAGCT GACTTGAGAG AGTTTATCCT 1B0

GGATTATCCA AGGGGCCCAG TGTAATTCCA AGAGCCCTCA AGAGCAGAGC TGGAGAGATG 24 0

CCGCGCAGGA GGCCTGGGTG CCGTTTCGGA GCAGGATGGA AGGCGGTGAA TCCCGCCTCC 300

AGCATGGAGC TCGGGAGAGG CCCTGACTGC AGATGGAGAG GCTGCCCTGG CCGCAGCGCA 360

CGGGGCTCCT GACC CACAAA AATCGCGAGA TAATGAGTTC ATGTTGTTTG AAAGTCCGTC 420

GAATTCGGCC
CTGGTCATGA
TTACAGGCAT
ATTCTGGCTG
ATTATCTTCT
TAGTAAAGCA
AGTCTTGCTG
TTTGCACAGA
TAAATCACAA

TTCATGGCCT AGTATTTTTG
ACTCCTGACC TCAGGTGATC
GAACCACTGC ACCCAGTCAA
TGGAAGACCC CAAGATTCTT
CTGTCCCACT CTTCCCCTTC
AATTTAAGAT AATTTTCTGC
ATAATGATAG ACATCCTGGG
CTGAGAATTA TGACTGAGGA
GCTAGGCTTG GCAATATGAG

TAGAGACGGG GCTTCAGCAT ATTGGCCAGG
CTCCTGCCTC AGCCTCCCAA AGTGCTGGGA
GGG TATAAAA TTTCTACACA GCACAGGCAG
TGGAATTGTG ATGCTTTATT TAATTTAGAG
CTAAAAAGGA CTAGATGCTT GCTGCTTAAT
TTTGAGATTT AGGGATAGAT TTTTTAACAT
ATGTTGGAAA TTAGGAAACT TGAACTTTTA
AAAGTTAGAG GATCAGAAAA AATAAATTTA
TGGCGCTCGA G

60
120
180
24 0
300
360
420
480
521

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ATTTCTGGTA ATTTGCTATA TAAAACTATT GCTATACGAT TAAAAACTAA TACAGAAGAA 4 80

TATTTCTTTA ACATTATGTT AAAAAGGAAA AAAGCTAACA TTTTCTTTAT AG C AAAACAC 54 0

TGCCATGATT TACATTAAAA TTAGGAACAT ACTCGAG 577

(2) INFORMATION FOR SEQ ID NO: 617:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 17;

GAATTCGGCC TTCATGGCCT AGCACATACA GTATAAAAAA TAATCACCCA C CAT AATTAT 6 0

ACCAAATTCC TCTTATCAAC TG CAT ACTAA GTGTTTTCAA TACAATTTTT TCCGTATAAA 120

AATACTGGGA AAAATTGATA AATAACAGGT AAGAGAAAGA TATTTCTAGG CAATTACTAG 180

GATCATTTGG AAAAAGTGAG TACTGTGGAT ATTTAAAATA TCACAGTAAC AAGATCATGC . 240

TTGTTCCTAC AGTATTGCGG GCCCTCGAG 269

(2) INFORMATION FOR SEQ ID NO: 618:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:618:

GAATTCGGCC TTCATGGATT CTGCTTTGAA TATAG CTACA GAAATAAAGG ATGGACTACA 60

ATGTGGGACA GTGTCTTCTC AGAAACAACC AGCCTTGAAG GCTACAACTG ACGAGGAAGA 12 0

TTCTGTTTCG AATATAGCCA CAGAAATAAA GGATGGAGAA AAATCTGGGA CAGTGTCTTC 180

TCAGAAACAA CCAGCCTTGA AGGCTACAAC TGACGAGGAA GATT CTGTTT TGAATATAGC 24 0

CACAGAAATA AAGGATGGAG AAAAATCTGA GACAGTGTCT TCTCAGAAAC AACCAGCCTT 3 00

GAAGGCTACA ACTGACGAGG AAGATTCTGT TTCGATTATA G CCACAG AAA TAAAGGACGG 360

AGAAAAATCT GGGACAGTGT CTTCTCGGAA AAAACCAGCC TTGAAGGCTA CAAGTGATGA 42 0

GAAAGATTCT TTTTCGAATA TAACCAGAGA AAAAAAGGAT GGACTCGAG 46 9

(2) INFORMATION FOR SEQ ID NO: 619:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 619:

GAATTCGGCC TTCATGGCCT AGTCCGTGTT. GTGGTCAGTG TGTGAACTCC ACACTGGACA 6 0

GTAGCTGAGT TTGGGCAGGG ATGAGGAGTG GAGGGGTGAG GTCTAAGGTT CAGAAAAAGT 120

TTGTGTTTAA GAACTTGGTT ACACTGGAGT CAGTTG CAGA CCAGAATGGA GAAAAGCACT 18 0

CCTGACTTGA GTTGGGTGTG CTTGGGACTG GATCACCTTT GACCTTCTTT ATTTAC CTAA 24 0

296

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TTGGAGGGAA GAGCAGGGGA GGCAACACTA TTTCTCTTGG GTGTTAGAAG AAGATTCGAG 3 00

CTTATTTGGG CACTGGTCTC TATCTTTGCC TTCAGCTGAA TCAACATCTA AGATGTTTTA 360

GATGCTTAGC TAATTCCTCT TAAAAAAAGA ATAAGCAGAG GCCGGACGTG GTGGCTCATA 420

GCTGTAATCC C AG C AGTGTG GTCTCGAG 44 8

(2) INFORMATION FOR SEQ ID NO: 620;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 57 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
CD) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 620:

GAATTCGGNC TTCATGGCCT ACTTAAATCC ATCAAGTTAC ACAATCGATC TGTTGTCAGC 60

TGAACAGAAC CACATTAAAT TTAAGCCAAA CACACCAATA GGAATGTTGG AGGTAGAGAA 120

GGTAATTTTA AAGCCAAAAA TGTTGGATAA GAAAAAACCT ACACCTATAA TACCAGAGAA 18 0

AACTGTGAGA GTAGTGATTA ATTTTAAGAA AACACAGAAG AC CATAGTG A GAGTGAGTCC 24 0

ACATG CATCG CTTCAAGAGC TTGCCCCTAT TATATGTAGC AAATGTGAGT TTGATCCGTT 300

GCATACACTA TTGTTGAAAG ATTATCAATC GCAGGAGCCT CTTGACTTGA CAAAATCTCT 36 0

TAATGACCTG GGACTAAGAG AATTATATGC GATGGATGTC AACAGAGAGT CCTGCCAAAT 42 0

ATCACAAAAC CTAGATATTA TGAAGGAGGC CCTCGAG 457

(2) INFORMATION FOR SEQ ID NO: 621:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 287 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 621;

GAATTCGGCC TTCATGGCCT ACTCTCTGAT TTACAGATTG CTAATTAAAT GGCTATTATT 6 0

AGTTTGGATT AATTAGACTT AAGAAAACAA CTAACTGAGG GTTTTTTTTG TTTGTTTTTT 12 0

GAGGGTTTTC TTTGCATGAG AATTGTATGT AACCAG TGAT ATGATTATTC CTGAATGTAC 18 0

AGACAGAAGT AAGCCTGGAC ATTGTTAAAT AGTCCCTGCT TTAAGGGACT ACGATAATGT 24 0

GTACTATGAC AAACGTGCTT TATTCTTCTA ACGCAGTAAG TCTCGAG 287

(2) INFORMATION FOR SEQ ID NO: 622:

(i ) . SEQUENCE CHARACTERISTICS:

(A) LENGTH: 328 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 622:

GAATTCGGCC TTCATGGCCT AGTAGGTGTA TCACAGATTT C TAATGTAG A ATGGTCAGTC 60
CAGGAGTAAT TGTAATTGTG GAAAAATGGA GAATTATAAA ACAAGAATGA TGTGCAAAAA 120
AGGACACAGT TGAATTCATC TGTGTTCCTC TAAACTATTT CATTTACTCA TTCATCCAAG 180

297

WO 98/45437

PCT7US98/06956

TTTTGAAAAA TGTTGGGAGT CTGAAAAATT CCAGGCACTC TGGATAAATG AGTATGGAAG 24 0

AATCCTCCAA AAGAACTTTT AGTCTACAGG GGAACATTAA TAAGCAATCA GGGACTTGAG 3 00

ACCTACAGTG CTGTGGAAGA TTCTCGAG 32 8

(2) INFORMATION FOR SEQ ID NO:623:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 75 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 623:

GAATTCGGCC TTCATGGCCT AGGACGTTTG GGTTGTTTCC ATCTCAAATA AATAAATAAA 6 0

TAAAAGTCTA TAAAAACAGC TGGGCCCAGG CATTTAAAAA AATGTTCGGT CTTCTAGTTT 12 0

AGTCTTTTAT TGTCTATGCA AATTCTTTGG CTATTGAACT ATCCAAGCTT TCTCTTTTTA 180

AGCTTTTGGG GAATAGGTTG CAATACATTT CTTGTCTACT GTTTCTCTTA GTGTTTTCTA 24 0

ATTCTAACCC ACTGTTTTTG GAATTTCTAT TAGATGGTTT TGCAACTTCT G CATC TAT CC 3 00

TCCATGCACC TTCACATTTC CTTCACAGTT TTCGTGCTGT TTT.CCTTGTG TGCTACATTC 36 0

TGCACAGGAC TCGAG 375

(2) INFORMATION FOR SEQ ID NO: 624;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 763 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 624:

GAATTCGGCC AAAGAGGCCT ACCTCAAAGG ATTGGCTAAA AGCAAGCAAC TGGATTGAAC 6 0

ACCCTAAGAA GAAAGATTCA CACTGCACCA GGAGACATCA GAAAGAATGA AAACTCTGCC 12 0

GCTGTTTGTG TGCATCTGTG CACTGAGTGC TTGCTTCTCG TTCAGTGAAG GTCGAGAAAG 18 0

GGATCATGAA CTACGTCACA GAAGGCATCA TCACCAATCA CCCAAATCTC ACTTTGAATT 24 0

ACCACATTAT CCTGGACTGC TAGCTCACCA GAAGCCGTTC ATTAGAAAGT CCTATAAATG 300

TCTGCACAAA CGCTGTAGGC CTAAGCTTCC ACCTTCACCT AATAACCCCC CCAAATTCCC 36 0

AAATCCTCAC CAGCCACCTA AACATCCAGA TAAAAATAGC AGTGTGGTCA ACCCTACCTT 420

AGTGG CTACA ACCCAAATTC CATCTGTGAC TTTCCCATCA GCTTCCACCA AAATTACTAC 48 0

CTTCCAAATG TGACTTTTCT TCCCCAGAAT GCCACCACCA TATCTTCAAG AGAAAATGTT 54 0

AACACAAGCT CTTCTGTAGC TACATTAGCA CCAGTGAATT CCCCAGCTCC ACAAGACANC 600

ACAGGTGCCC. CACCCACACC TTGTGACAAC TACACNAGCT CCACCATCTT CCTCAGCTCC 660

AC CAGAGACC ACAGTNGCCC CACCCACACC TTTTGCAACT ACACNAGCTC CACCATCTTC 72 0

CTCAGCTCCA CCAGAGACCA CAGCTGCCCC ACCCATCTTC GAG 763

(2) INFORMATION FOR SEQ ID NO: 625:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 476 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

298

WO 98/45437

PCT/US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 25:

GAATTCGGCC AAAGAGGCCT AGTAGTTTCT ATGTGCGGTC
TGTGTTCCAC TGGTTTCCAC CACGTTGACA GCAGTCG CTG
GTCATGCTGG TCTGTTCCAG GACTCTGTGG AAGATTCTCT
AGAGGAAATG GAAGGACTCA CAGGCAGAGC AGATCTCATC
ATTACTTTGG GTCGAAACAT TATTGTGAAC ACTAAGTTCT
TTTCATTTGT AGAGTTCGTC TAGAATATCG TTTGCTGGGC
TCTTCTTGCT TTATTGGTTT TTGTGGTCTG ATACTCTGTT
TGATCCTAGT CGAATAAATC CTGATCGATG AGAACTCTTT

TGGGGTGGGG GCAAGGCCCT
GCAGCAGAGA GCCATTTCCT
ATCTCCACTG GCACAGGAGC
CCCCAAGCCT GTTGGGAGCC
TCAGGTTTTG TAG CACATG C
CTTCTTTCAA AGGATGTTGA
TTCCCACTAT ATCTAAATCG
TGGACGGGGC CTCGAG

60
120
180
240
300
360
420
476

(2) INFORMATION FOR SEQ ID NO: 626:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 4 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

Ui) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 626:

GCGATTGAAT TCTAGACCTG CCTCAACTGT CTGGTTTCCT GTAAAATAAA CACATTGTTT 60

TATATTTTTA GGGAACAAAA AGTGCTGCTA TAGGGTTCAA AGTTTTCCTT CTGAACACTT 120

TTCCGAAACA AATTACCCCA AAGACACATT TTGAATATCC TGGTCACATC TTTGGATCTG 180

TAAAATATAC CTTTTAGTAT GGCACCTGTT AAAATGCAAA GCAAAAACCT CGAG 234

(2) INFORMATION FOR SEQ ID NO: 627:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 583 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 627 ;

GAATTCGGCC TTCATGGCCT AGGCCTTGTG AATCATTCAG CATAAGGAAC TGTCAATATT 6 0

TTTTTGAGCT GTCAGAAATC CATTTAGTGA TTTTCGACAA TTCAAAAAAA TATTTCTGAC 12 0

CGCTTGATTC AGTTCCTAGT GAATTAGGGA AGAAGAGGAA TAAAAGAAAT ATATCAATCT 18 0

AAATTATGAA CCCAGAGTCT AGCTTCCTGA ATTCTTCTCT GTG CTTAAAC GAACAACAGG 24 0

ATGTTGAGGT TCAAAAATAC TCTCTTCTAT TTCCCCCCCT TCCTTCCCTT TTCTTTCCTT 300

CTCTTCCATT . CCTCGAAAAG ATAATAAAAC AGAATGTGCC TAGAGCTTCT GGAAAGAATA 360

CAGTCCTGCT GATACTAGAA CTCAGTGAAA TTTGCACCAG ATTTCTGAGC TACAGAACTG 420

AAGATAATTC ATTTATTTCA AGCCACTGAG TTTGTGGTAA ATTTGTTACA GTAGCAATAA 480

AAATCTAATA CATGCCTTCT ATACCAGAAG TACACATCCA CGTGACCATT CCTGTCCTCA 54 0

CCCCACACAC ACATACACAC ACACACACAC ACGCACACTC GAG 583

(2) INFORMATION FOR SEQ ID NO: 628:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 295 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

299

WO 98/45437

PCT7US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 628:

GAATTCGGCC TTCATGGCCT ACCTGCCTCG AGTTCCTACT GCCCCCGGGC GGCCTGCACA GO

GAGCTGCTGC CCTCCAGAGA CTGTGAATCC CAAGCCTGAC TCAGTGGACT GCTTCCTGTT 120

CCCCTCCCTC CTCTTCCTCA CCTTGTTCTG CACCCTCAAG CCTTTCTCCA ATGCCTCCCA 18 0

GGAGGATTTG GGGACTTTCT CCCTGGGGCG CCCAGATCCA GCTCGGAGGC CTCACTGGGA 24 0

CCTGGCAAGG CCTGACCTCC CGCCCAAACT TGCTTCTGTA GCCCCCCTAC TCGAG 295

(2) INFORMATION FOR SEQ ID NO: 62 9:

(i) . SEQUENCE CHARACTERISTICS :

(A) LENGTH : 344 base pairs

(BJ TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 62 9:

GAATTCGGCC TTCATGGCCT AACCTGTTGC TTCCCCTGGG ACTGAAGGCA GAAGTGACTC 60

CCGAAATTCT CTTTCTGGAC TCAGAAGGAA ACCAAAGCAA TTGATGACAC CGCATCCCAT 120

ACTAAAAGCT ATGGAAGAGA GAG CAATT CA ACGAGCTGAA TGTAGGCGGA TCTTGGCAGA 18 0

GAAGNAGAAA AAACAAGAAG AAGANAAATT GGCCCAGTTA AAGGCCCAAG AGGAGGAACG 24 0

TCAGAAAAGG GAGGCAGAAG AAAAGGAGGC ACAGCTTGAA AGAAAACGAG AAGAGAAGAG 300

ACTGAAGAAA ATGAAAGAAC TTGAGAAGCA GAAGAGAACT CGAG 344

(2) INFORMATION FOR SEQ ID NO: 63 0:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH; 257 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63 0:

GAATTCGGCC TTCATGGCCT AGTTCTTCCT TAGGAACAAG GGCAGGACCT CAAACAGTCC 60

AGAGGAGAAG CCTGGGGTGG TCAGGGAAGG CTTCCTGGCT GAGAGGACAG GCTTAGGGGC 120

ACCTTGAAAG TTCAGGCTGA CTGGGGCTAG GGGCATGTGG GTAACAGGTT AAAGGGGGGG 1B0

GGGCTGGAAA ATGCAGACAC CAAAGAC CCT TCAATATGAG GCCAAGAAAG GAAGGTTCAG 24 0

AACAGGGATC. ACTCGAG 257

(2) INFORMATION FOR SEQ ID NO: 631:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 326 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 631:

300

WO 98/45437 PCT/US98/06956

GTTCCAAATC CATGGGAACC AG CACAGGAG CTACAGCAAA TCATGGCACT TCTGCAGTAG 60

CAATTACTAG CCATGATTAC CTAGGACAAG AAACTTTGAC AGAAATCCAA ACCTCACCAG 120

AAA CAT C AAT GAGAGAGGTG AAAG CGGACG GAGCTAGCAC CCCCAGGTTA AGAGAACAGG 180

ACTGTGGTGA ACCTGCCTCG C CAG CAG CAT CCATCTCCAG ACTCTCTGGG GAACAGGTCG 24 0

ACGGGAAGGG CCAGGCAGGC AGTGTATCTG AAAGTGCGCG GAGTGAAGGA AGGATTAGTC 3 00

CAAAGAGTGA TATTACTGAG CTCGAG 326

(2) INFORMATION FOR SEQ ID NO: 632:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 480 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 632;

GAAAAAATGG AAGAATTTGT TTGTAAGGTA TGGGAAGGTC GGTGGCGAGT GATCCCTCAT 60

GATGTACTAC CAGACTGGCT CAAGGATAAT GACTTCCTCT TGCATGGACA CCGGCCTCCT 120

ATGCCTTCTT TCCGGGCCTG TTTTAAGAGC ATTTT CAG AA TACACACAGA AACAGGCAAC 180

ATTTGGACAC ATCTCTTAGG TTGTGTATTC TTCCTGTGCC TGGGGATCTT TTATATGTTT 24 0

CGCCCAAATA TCTCCTTTGT GGCCCCTCTG CAAGAGAAGG TGGTCTTTGG ATTATTTTTC 3 00

TTAGGAGCCA TTCTCTGCCT TTCTTTTTCA TGGCTCTTCC ACACAGTCTA CTGCCACTCA 3 60

GAGGGGGTCT CTCGGCTCTT CTCTAAACTG GATTACTCTG GTATTGCTCT TCTGATTATG 4 20

GGAAGTTTTG TTCCTTGGCT TTATTATTCT TTCTACTGTA ATCCACAACC TATTCTCGAG 4 80

(2) INFORMATION FOR SEQ ID NO: 633:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 307 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 633:

GAATTCGGCC TTCATGGCCT AGCGGGATCG TATCACTACG CACGTGGCGT CAATGACAAA 60

GACGCCTTCC CCACGGGACA GGCCCTGGGA ACTGCGGGGC AAGGTGTGGG CACGG CGGGT 120

CGCCTTCCAA CCCTCCAGGG TCTCCGGTCC TGCCCCCTCT CCAAGACCCA GAGATTCTCT 180

CCATCCGGTG CCTCCGGGAG CCCAGGGTCT GGGGAGTGTC TGGCTATGGC GGGGCGGCTG 24 0

CTTTTTAGGG GAGGGAATCC AGCATTTGGG AAACCAG AT C TGTTCTCCTT CTTTCCCTTC 300

CCTCGAG 3 07

(2) INFORMATION FOR SEQ ID NO: 634:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 58 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:634:

301

WO 98/45437

PCT/VS98/06956

CCTCTGCAAG AAATG CCTAA GCGTATTATC AGGAAGTGGA ATTATAAAAT GTTTCCAGAT 60

CAAATTAAGC ATCTACAGGT GAATTAATAT AG AATTAAG C TTAGAAAGCT TAAGTAGAAG 120

TTGAATGAAT TGTGTTCATT CTTTGAAACC CATTGATTTG CAAAACCAAT ATTCCACTGT 180

CTATAGGAGG CAATTCAGAC TGAAAATAAT TTAGAAAAAA AAATAGTCCA GAAAAAAAAA 24 0

TAGTTCTAGA GATAAATAGG TCATTTGAAG ACTAACCTCT GCCATTAGGG GTTTCTAAAG 3 00

ATAGGCTGAC TCTATCTATT TAATAATTAT TTTGTTCATT AACTCCTTGC ATATAGAATT 36 0

GTAACTGATA CCAGCCAGGT ACGGTGGCTC ACGCCTGTAA TCCCAGCACT TTGGGAGGCC 420

AAGGCGGGCA GATCACCTAA GGTCGGGAGT CTCTCGAG 4 58

(2) INFORMATION FOR SEQ ID NO: 63 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 635:

GAATTCGGCC TTCATGGCCT ACCCACTCTC ACTTTGTACC TCTGTCAGTT ATCTCCTCTT 60

TACCCTTCTT TCAACGAGCA TACCACCGGC CCTCCCAGCA CCTATGGCCC AAGCCAGTTG 120

TTTGCAAATT TTATACTGTG ACACAGGACA AT TTACACAC ACATACACAG TTTCACTTGT 180

GACATACTTT TTTTTTGAGA TGGAGTCTCA CTTCATTGCC CAGGCTGGAG TGCAGTGGTG 24 0

TGATCACACC TTATTGCAGC CTCAAACTCC TGGGCTCAAG TGGTCTTCCT GCCTCAGCCC 3 00

CCCTAGTAGC CAGGATTACA GGCGTGCACC AC CATTTCT C GAG 34 3

» (2) INFORMATION FOR SEQ ID NO: 636:

(i) SEQUENCE CHARACTERISTICS i

(A) LENGTH: 4 02 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63 6:

GTGGATAACA AACAAACAAA TCTGATGCTC CCTGAGTCAA CTGTTTATGG TGATGTGGAC 60

CTTAGTAACA AAATCAATGA GATGAAAACC TTCAATAGCC CAAATCTGAA GGATGGGCGT 120

TTTGTCAATC CATCAGGGCA GCCTACTCCT TACGCCACCA CTCAGCTCAT CCAGTCAAAC 18 0

CTCAGCAACA ACATGAACAA TGGCAGCGGG GACTCTGGCG AGAAG CACTG GAAACCACTG 240

GGACAGCAGA AACAAGAAGT GGCACCAGTT CAGTACAACA TCGTGGAGCA AAACAAGCTG 300

AACAAAGATT ATCGAGCAAA TGACACAGTT CCTCCAACTA TC C CATACAA CCAATCATAC 360

GACCAGAACA CAGGAGGATC CTACAACAGC ACAGAGCTCG AG 4 02

(2) INFORMATION FOR SEQ ID NO: 637:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 290 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63 7:

302

WO 98/45437

PCTAJS98/06956

GCTTCCTCGC AGCAAGCGGC TGGAGATAGA GAAGAGCTTA CTGGTGCGAG CGTCCGTCGA 6 0

CCCCGTCGCC GCTGACCTAG AGATGGCAGC CGGTCTCACC GACATATTTC AGCATGATAC 120

ATACTGTGGT GATGTCTGGA ACACCAACAA ACGCCAGAAT GGCAGACTCA TGTGGCTCTA 180

TCTCAAATAC TGGGAACTCG TTGTCGAACT GAAGAAGTTT AAGAGAGTAG AGGAAGCCAT 24 0

ACTAGAAAAG TAAGACAAGA GTGAAATCAA ACTGCTTTTA GTGACTCGAG 2 90

(2) INFORMATION FOR SEQ ID NO: 638:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 63 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63 8:

GTCGAGAAAA TGGGGATAAT GGAGAAATTG TGGGCAAGCT GGCTTCCTGG GAAGGGACTA 60

ATTGAACAAG ACAATGATTT ATCTTTTCGG GGTTCAGAGG CAG CTTGTTA ATTCGAATTA 120

TTTTCTTTAT TTTTGCCCAC AAGTGTTTGG TTGTCCTTTT CTCTGGCTTT TTACCTGATC 18 0

AGGCTGCAAG CTGCAAAGGT GTGGCTTGTG CTGCAGATTT GTAATAAAAG ATGACAGGTG 240

AGAGAGACAG TGGTGGAACT GGTAGAGCTT GCACACCCAC ACGGTGTGGC TGCTCGGGAG 300

GCTGTCTAGT GCACCTGCCA ACAGAGCACA GATATCCTCT CTTCCTCATT TCAGATTCCT 3 60

CCTTCCAGCT GTTTACTAAA CAGCAACAAA AACACCCTCT TGGCTGTAAC TTGTCAAATA 420

AAGTCCCTGC AAAGTGTATA AGATTTTCCT CCCCAACCTC GAG 463

(2) INFORMATION FOR SEQ ID NO: 63 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 513 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63 9:

GCGAGGGAGA TGGCAGCCTG GGCTTTAGCA GCAGGGAGGA AGGTGAANAA AGAACCGGGG 60

CTTGCAG CAG AGGTGGGTTC TGCCTTAAAG GCAGAGACCC CCAACAACTG GAATGCCACG 120

GAAGACCAGC ATGAGCCTAC CAAACCTTTG GTTCGCAGGG CTGGAG CTAA TTCTCGCTCC 180

AGGAGAAAGA AGCAGAAGAA GAACTCCAGG CAGGAAGCAG TGCCCTGGAA AAAACCCAAA 240

GGCATCAATT CCAACAGCAC AGCTAACTTG GAGGATCCTG AGGTGGGTGA TGCTGAAAGC 300

ATGG CGATCT CAGAGCCGAT CAAGGGCAGC AGAAAGCCCT GTGTGAATAA GGAGGAGTTG 360

GCTTTGAAGA AGCCCATGGC GAAATGTGCC TGGAAGGGTC CCAGAGAGCC ACCTCAGGAT 420

GCCCGGGCAG AAGCCGAGAG CCCAGGAGGC GCCTCTGAGT CAGACCAAGA TGGTGGCCAT 4 80

GAAAGCCCAC CAAAGAAGAA GGCCGAGCTC GAG 513

(2) INFORMATION FOR SEQ ID NO: 640:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 510 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:640:

303

WO 98/45437

PCT/US98/06956

GAATTCGGCC TTCATGGCCT ACACCTCAGC CTCCAGAGCA GCTGGGACTA CAAACGTGTG 6 0

CCACCATGCC GGGCTAATTT TTGTATTTTC AGCAGAGGTG GGGTTTCACC ATGCTGCTGG 120

CCAGGCTGGT CTCGAACTCC TGGCTTCAAG TAATCTGCCC ACCACAACCT CCCAAAGTGC 180

TGGGATTACA GGTGTGAGCC ACTGCGCCCA ACCAAGAGCT CCTTTTTGTT TTTCTTTTTT 240

TGTGAATTCG GATTCTTTAT ATTCAGGAGT TTTACTTAAA CTTTGAATCT GAAAGAAACT 3 00

TTAGGAGGAG CTCATAGATT TGTGGGAAGA AG CAAAT CTA CATTATTTTC TCTCTTCTAA 360

AATCATATTC CATGTATTTT GATCTTTTAC TGAATTTTAA CACATTGTTT CATCACTAAC 420

ATAAAGTGTT TCAATAGTTT TTGTAACTCA CACACAAATA CTGGATTTAA AAGTTATATA 4 80

CCTGAGTATA TTTTTATGGC AGGTCTCGAG 510

(2) INFORMATION FOR SEQ ID NO: 641:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 308 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:641:

GAATTCGGCC TTCATGGCCT AGTGTTCCCA GCCAGTCTCT ATTCTCTCAC CTAACACTCT 60

CAAGGAGATA GAAGCTTCAG CTGAAGTCTC ACCCACCACG ATGACCTCCC CCATCTCACC 12 0

CCACTTCACA GTGACAGAAC GCCAGACCTT CCAGCCCTGG CCTGAGAGGC TCAGCAACAA 180

CGTGGAAGAG CTCCTACAAT CCTCCTTGTC CCTGGGAGGC CAGGAG C AAG CG CCAGAGCA 240

CAAGCAGGAG CAAGGAGTGG AGCACAGGCA GGAGCCGACA CAAGAACACA AG CAGGAAGA 300

GGCTCGhG 308

(2) INFORMATION FOR SEQ ID NO: 642:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 05 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64 2:

GAATTCGGCC TTCATGGCCT AGTTAGATGA AAATCTAAAG GATGAATACT TTGAGGAAAT 60

CATGGAAGAA TATGAAGATA TTAGACAGGG CCATTATGAG TCTCTCAAGG AGAGGAGATA 120

CTTACCCTTA AGTCAAGCCA GAAAAAGTGG TTTCCAAATG GATTGGCTGT CTGAACCTCA 18 0

CCCAGTGAAG CCCACGTTTA TTGGGACCCA GGTCTTTGAA GACTATGACC TGCAGAAGCT 24 0

GGTGGACTAC • ATTGACTGGA AGCCTTTCTT TGATGTCTGG CAGCTCCGGG GCAACCCCAC 300

TCGAG 305

(2) INFORMATION FOR SEQ ID NO: 643:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 301 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO:643:

304

WO 98/45437

PCT/US98/06956

GCGATTGAAT TCTAGACCTG CACCCAGCCA ACACTGAGAG ATTTTAATGA GTACTTTTAT 60

CCACCTGACC ACCATCATTA CCTATCACCT GTCATTCTTC ATCCACCCTA CATCCATCCT 120

TCATCCCCCC ATCATCCACC CATCTATCCT TCATCCATCC ATTCATCATG GAACCATTAT 180

CCATCCAACT ATCATCCAGC CAGCCAGAAA TGACCCATTC ATCTTCATCT CTCATTTCCT 24 0

CTCTCTAAAC CAGTTCTTAA TCTGGGGCCA AAGTCCTACC CACACATCCC TTAGTCTCGA 3 00

G 301

(2) INFORMATION FOR SEQ ID NO: 644:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 08 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 644.:

GAATTCGGCC TTCATGGCCT AGATCCCCCG TGGAGAAAGC AGTGACACAT TCACACAGCT 60

GTTCCCTCGC ATGTTATTTC ATGAACATGA CCTGTTTTCG TGCACTAGAC ACACAGAGTG 120

GAACAGCCGT ATG CTTAAAG TACATGGGCC AGTGGGACTG GAAGTGACCT GTACAAGTGA 180

TG CAAAGG AG GGTTTCAAAG AAAAAGGATT TTGTTTAAAA TACTTTAAAA ATGTTATTTC 24 0

CTGCATCCCT TGGCTGTGAT GCCCCTCTCC CGATTTCCCA GGGGCTCTGG GAGGGACCCT 3 00

T CTAAGAAG A TTGGGCAGTT GGGTTTCTGG CTTGAGATGA ATCCAAGCAG CAGAATGAGC 3 60

CAGGAGTAGC AGGAGATGGG CAAAGAAAAC TGGGGTGCAC GCCTCGAG 408

(2) INFORMATION FOR SEQ ID NO: 645:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 64 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

fxi) SEQUENCE DESCRIPTION: SEQ ID NO: 64 5:

GAATTCGGCC TTCATGGCCT AGTTATGTGA TTAGGAGTAG GGTTAGGATG ANTGGGAAGA 6 0

AGAAAGAGAG GAAGTAAAGT TTAATTATGC CTTTTTGGGT TTATTATCCC TGATG CATGT 120

GGCCCCCCAC TGCTGTGTCC TTCTCCTGTT GGCTAGGGTT AGACCACACA GGCTAAACTA 180

ATTCCGATTG GCTAATTTAA AGAGAATGAC GAGGTAAGTG TTTTGGCGGG AAAAATGGTT 24 0

ATGACAGAGC AGGTAATAGG AATGAGTTAG GGTGGAGTAG GTAATCGGAA TGAGTCAGGG 3 00

TGGAGCAGGT AATTGGAATG AGTCAGGGTA GAG CAGGTAA TCGAAAAAGG TTGCTTTGCT 360

CGAG 364

(2) INFORMATION FOR SEQ ID NO: 646:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 320 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64 6:

305

uJhlliWHIUrii

WO 98/45437 PCT/US98/06956

GAATTCGGCC TTCATGGCCT AGGAGTGCAT TTGGATCTAG TG TTTTCT AT CAATCTGTCT 6 0

GCTGATGTGG CACTACTGCA CCATTTACCA CAACATTAGA ATATGTCTGA GTAACTGGTT 120

GGCTTAGATT TTTTGCATTG AGTCCCACCC CATTTTCCAG AACTTTCATG GCTATTCTTA 180

TATGTTTGTT TTCCGTAAGA TCTTTAGGAT CAATTTGTCT AGTTCTAAAG AGGAAATTCT 24 0

GATATTATTG ATTTAGTAAC TTTCCATGAA AAAAACCTAC CAT CAC AGG A AAGATGCACA 3 00

TTAATTACAG GTAGCTCGAG 3 20

(2) INFORMATION FOR SEQ ID NO: 64 7:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 267 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64 7:

GAATTCGGCC TTCATGGCCT AGTCAGTGGC TAGATTGATT GATCCTCCAG AATTAGACAC 60

TCACATGTTA ACACCAGTCT CAGTTGGAGG GCTGATAGTA AACCTTATTG GTATCTGTGC 120

CTTTAG C CAT GCCCATAGCC ATGCCCATGG AGCTTCTCAA GGAAGCTGTC ACTCATCTGA 180

TCACAGCCAT TCACAC CAT A TGCATGGACA CAGTGACCAT GGGCATGGTC ACAGCCACGG 24 0

ATCTGCGGGT GGAGGCGAGG TCTCGAG 267

(2) INFORMATION FOR SEQ ID NO: 64 8:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:648:

GAATTCGGCT TCATGGCTAC TTTTGGTAAA GCATACCCAA CCTTCAGTTA GAATATCTCC 60

TGATAATAAG AAAGATCTCA TTGAAATTTA TTAATTCTTT TGTGTCTAGT AGATAACTTG 120

GATGGCACAC AGTGCTTTGA TTTTTACCTG CCCAGAATTT AACTCCTCAT CCTATCCTAC 180

ATGATTTTCT TTTTCCTCTC CCCCTTCCTC TTTTATTCCA TGTCACTGGG AATGGCAGGT 24 0

CTTGCACCAA GTAATGGCAG GTCTTGCACC AAGCAAGCCA GAAACCTGAG CTTTAGTCTT 3 00

TATTCCTCCC CACTTCTCGA G 3 21

(2) INFORMATION FOR SEQ ID NO: 64 9:

(i) .SEQUENCE CHARACTERISTICS:

(A) LENGTH: 559 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 649 :

GAATTCGGCC TTCATGGCCT AGAGGAAGTG AACGGATGGG GCCTCATCCT CCTGCCTCCC 60
TAAAGGGTGA GGGTGGAAGG ATGGGGCTGT GCCCTCTTAG GG CAGGG AAA AACAGCTTGG 12 0

AGGGGTTTCT GCCATCAGAG AT CCCATAGG AGGCAGGTCA GTCCTGCAGA ATTTCTCCCC 1B0

306

WO 98/45437

PCT/US98/06956

AGTCTGGCCT
TCCTGCCACC
GTCTTGATAT
CTCTCCTATA
AGATATACAC
TTAGCATACT
ACACATCATA

CCAGCCTCCC
GGGCCTCTGC
TTTTGCTGGA
TCTCAGTCAA
AGATTAGGAA
GGTATATACA
TTGCTCGAG

TGGCCCCTTT
ACAGTCACCT
ATGCAGACGA
TTTACATAGT
ACGCTTACAA
ACAGTG TG AT

CTAGAGGCCT
CCTGCAGCCT
TACTATAT TT
TTAAAATAGA
CATACAAATA
ACAATAAATA

CCATCCCACT
GGGGTGTGTC
ACCGTATAAT
ACATCTTATT
CACAAACTAG
ATTT CATTCA

GGCGGCTTGC
GCCTCTCCAC
ATATTATCAG
AAAAACATCT
AAATAAATCT
TGCTCTATCT

(2) INFORMATION FOR SEQ ID NO: 6 50:

CiJ SEQUENCE CHARACTERISTICS:

(A) LENGTH: 477 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS s double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:6S0:

240
300
360
420
480
540
559

GAATTCGGCC TTCATGGCCT AGGGAGACTG AGG CAGGCAG ATCACCTGGG GTCGGGAGTT 60

CGAGACCAGC CTGACCAGCA GGGAGAAACC CCGTCTCTAC TAAGAATAGA AAATTAGGTG 12 0

TGGCGGTGCA TGCCTGTGGT CCCAGCTACT CGGGAGGCTG AGGTAGGAGA ATCGCTTGAA 18 0

CCCGGGAGGC GGAGGTCATG GTGGGCCGGG ATTGCACCAT TGCACT CCAG CCTGGGCAAC 24 0

AAGAGTGAAA CTCCATCTCA AAAAAATAAA AGCCTAGCCT CCCAAAGTGC CAGGATTACA 300

GGCATGAGCC ACCGCGCCTG TCTGTCCGCC CGTCTTCTTT TTTAAG AG CA AGAAAAGGTT 360

TCCCAGAAGT ACTCTGGTAG ATTCTTATCA CACACACATT CCTAAACCAG TTACTGGCAA 420

AGAAAATAGA ATTATCATGA TTAATTAGCA TATTCTGAAG NACATGCTTC CCTCGAG 4 77

(2) INFORMATION FOR SEQ ID NO: 651:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 414 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 651:

GTGTGAACCT ACGGGAAGGC GGCCGCCTGC ACCTCTGTGC GGAGACCAAG GATGATGCCC 60

TAGCATGGAA GACAGCACTG CTGGAGGCAA ACTCCACCCC GGTGCGCGTC TACAGCCCGT 120

AC CAAG ACTA CTACGAGGTG GTGCCCCCCA ATG CACACGA GGCCACGTAT GTCCGCAGCT 180

ACTACGGACC GCCCTACGCA GGCCCTGGCG TGACGCACGT GATAGTG CGG GAGGATCCCT 240

GCTACAGCGC CGGCGCCCCT CTGGCCATGG GCATGCTTGC GGGAGCCGCC ACTGGGG CGG 3 00

CGCTGGGCTC GCTCATGTGG TCGCCCTGCT GGTTCTGAGC CCTGGGACTC GGAGCACTGA 360

CCCCTGCGCT TGGATTGCTA GACTCCTCTT CCTCCTGGAC CCCATCCTCT CGAG 414

(2) INFORMATION FOR SEQ ID NO:652:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 325 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 52:

307

WO 98/45437

PCT/US98/06956

GAAGGAAAAC ATGGG CACAG GGGATTTTAT CTGCATTTCC ATGACTGGAG GGGCGCCCTG 6 0

GGGGTTCAGA TTGCAAGGTG GCAAGGAGCA GAAGCAGCCC TTACAAGTTG CAAAGATTCG 120

AAATCAGAGC AAAGCCTCTG GGTCTGGGCT CTGTGAGGGA GATGAAGTGG TTTCCATCAA 180

TGGCAACCCT TGTGCAGATC TCACCTACCC TGAAGTCATC AAGCTCATGG AAAG CAT AAC 24 0

AGACTCTCTC CAAATG CTC A TCAAAAGACC ATCCAGTGGA ATAAGTGAGG CTTTGATATC 3 00

TGAAAATGAA AACTCTAACC TCGAG 325

(2) INFORMATION FOR SEQ ID NO: 653:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 443 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 653:

GAATTCGGCC TTCATGGCCT AGGTATTTAG GCTTTTGTCT TAACAGCAAA TCCTGGCTGT 60

CTGGGGCCTG ATGACTGTGT TCCATGGGTA TCCACTCCCT GTCCACAGTG TGGGAGCCCC 120

TCAGCTGCTT ATTGCAGGGA CACAGAGCCC GGCATGGTCC AGAAGGCGGG CTTATGGGGC 180

CTGCAGCACA CAGGGAAAGT GAGCCCACAC TGTGATAGGA GGGCAGACAC ACAGGATGTG 240

TTCTGTGTTA CAGGGTTGCC GTGAAGAATT TCATTCTTTT GCAAGGACTG GAGAGAAAAT 300

TTTATGTGGA AGGTAGCCCT TGGAAATGAC CTCAAAGAAT AGGTAGGATC TTAGCCTGCG 3 60

TTTGAAAGCC TGGAAAAAAA CAGGATGACA GGATGAAGAG GCCACAGCAC AGCTGCAGAC 42 0

AATGGGAGTG CGGAGATCTC GAG 443

(2) INFORMATION FOR SEQ ID NO: 6 54:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 311 base pairs

(B ) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:654:

GGGAGCGCCG GTGGTTCATC CTGACCGATA ACTGCCTCTA TTACTTTGAA TACACAACAG 60

ATAAGGAGCC CAGGGGAATC ATCCCGTTGG AAAACCT CAG CATCAGGGAG GTGGAGGACC 120

CCCGGAAACC CAACTGTTTT GAGCTCTACA ATCCCAGCCA CAAAGGG CAG GTCATCAAGG 180

CCTGTAAGAC GGAGGCCGAC GGCNGCGTGG TAGAGGGGAA CCATGTGGTG TACCGGATCT ' 240

CAGCCCCGAG CCCGGAGGAG AAGGAGGAGT GGATGAAATC CATCAAAGCC AGTATCAGCA 3 00

GATCCCTCGA G 311

(2) INFORMATION FOR SEQ ID NO:655:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 46 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 655:

308

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PCT/US98/06956

GGGGGATACG GAT AC C C AAA CTTCAATGTT CCTTGATAGT AGGAAGGAGG ACAGTTATAT 60

AGACCATAAG GTGCCTTGCA CAGATTCACA AGTGCAGGTC AAGTTGGAGG AC CAC AAAAT 120

AGTAACTGCC TGCTTGCCTG TGGAACATGT TAATGAGCTG ACTACTGAGC CAGCTACAGG 180

GCCCTTTTCT GAAACTCAGT CATCTTTAAG GG ATT CTGAG GAGGAAGTAG ATGTGGTGGG 24 0

AG AT AG CAGT GCCTCAAAAG AGCAGTGTAA AGAAAACACC AATAACGAAC TGGACACAAG 3 00

TCTTGAGAGT ATGCCAGCCT CCGGAGAACC TGAAC CAT C T CTCGAG 34 6

(2) INFORMATION FOR SEQ ID NO: 656:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 116 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 656:

GAATTCGGCC AAAGAGGCCT ACTAAACCGT CGATTGAATT CTCGAGGCAG GTCTAGAATT 60
CAATCGACGG TTTAGGCTCC CTATAG TGAG TCGTATTAAT TTCAGAGGTG TATTTA 116

(2) INFORMATION FOR SEQ ID NO: 657:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 82 base pairs

(B) TYPE: nucleic acid
{C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 57:

GAATTCGGCC AAAGAGGCCT AGGGATGAGG GTGAAGAAGG GGAGAGGGTT GGTTAGAGAT

ACAGTGTGGG TGGTGGGGGT GGTAGGAAAT GCAGGTTGAA GGGAATTCTC TGGGGCTTTG

GGGAATTTAG TGCGTGGGTG AG CCAAGAAA ATACTAATTA ATAATAGTAA GTTGTTAGTG

TTGGTTAAGT TGTTGCTNGG AAGTGAGAAG TTGCTTAGAA ACTTTCCAAA G TG CTTAGAA

CTTTAAGTGC AAACAGACAA ACTAACAAAC AAAAATTGTT TTGCTTTGCT ACAAGGTGGG

GAAGACTGAA GAAGTGTTAA CTGAAAACAG GTGACACAGA GTCACCAGTT TTCCGAGAAC
CAAAGGGAGG GGTGTGTGAT GCCATCTCAC AGGCAGGGGA AATGTCTTTA CCAGCTTCGG

TGGCTGGCAC GTGTTACCAG GCCGAGTGGG ATGACTATGT GCCCAAACTG TACGAGCTCG
AG

(2) INFORMATION FOR SEQ ID NO: 658:

(i) . SEQUENCE CHARACTERISTICS:

(A) LENGTH: 430 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 58:

GAATTCGGCC AAAGAGGCCT AGTCGAGTCC CTTCTGTCCC AGTCGTTCGT GCCTCTTGTC 60
CCACGCAACT CCAGCTTGTA CCATG CCGGT CAAAG GAGGT AG CAAGTG CA TCAAATACCT 120
GCTCTTCGGA TTTAACTTCA TCTTCTGGCT CGCTGGCATT GCAGTGCTTG CTATTGGACT 180

60
120
180
240
300
360
420
480
482

309

WO 98/45437 PCT/US98/06956

ATGGCTCCGA TTCGACTCTC AGACCAAGAG CATCTTCGAG CAAGAGAATA ACCATTCCAG 24 0

TTTCTACACA GGAGTGTACA TTCTGATTGG AGCCGGGGCC CTCATGATGC TGGTTGGTTT 3 00

CCTGGGCTGC TGTGGAGCTG TACAAGAGTC CCAGTGCATG CTGGGATTGT TCTTCGGGTT 3 GO

CCTCTTGGTG ATATTCGCCA TTGAGATAGC CGCCGCCGTC TGGGGCTATA CCCACAAGAG 4 20

TCGAGTCGAG 4 30

(2) INFORMATION FOR SEQ ID NO: 659:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 290 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 59:

GAATTCGGCC TTCATGGCCT AAGAGTACAG AGATTTCACT T CAT CTTGTG CTAATGTTTA 6 0

ATTNAAAGTA TATTGACACT AGTAAAGACA CTTTATTTTA ATTTG AG GT A TAAATGTCTA 120

CCTAAAATAG ACTATTTCCA TTGAGTCATA CATTTTAAAT GTGGTATATA TTCTTATATT 180

TCAGAAAATG ATAACTATCA TAGAAATCTA ATACTCATTA ATTTGATTAA TAATTATTTT 240

TTTCCTCAAA TTTGGAAATA TCTTTTCCTA TGTAATGGTC ATGTCTCGAG 290

(2) INFORMATION FOR SEQ ID NO: 660:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 406 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
•(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 66 0:

GAATTCGGCC TTCATGGCCT AGT CAGAAGT CTTTGTGTCC CTGTTTTTGT GTCCATTTCA 60

TGTACCTTGG CACTTTAAGG CTTGTCCTGC AAAATAAAAC ATTGCATCAT CACTTGTGAA 120

GGCAGAGCTT GGGAGTTTGC ACTGCTAAGA TGAGGATAGG AAAGAAATTT ATGCCGCAGG 180

GCCTTTGATG CTGCCCACTC ACCTGTCTGC ACAGCCAGGG CACGGCCAGC GGGAGTGGAG 24 0

AAGACGAGCG AGACCAAAAC CTTGCCGTGG GGAGGAGGGT GGCATAGCCA TTGATAAATC 3 00

GGGACTTGAA CTATCCCATC ACTCTAAAAA TATTTTTTAT CTGATTACAA AAGTAATAGA 360

TGGCCAGGCA TGATGGCTCA TGCCTGTAAT CCCAACACTC CTCGAG 406

(2) INFORMATION FOR SEQ ID NO: 661:

(i) . SEQUENCE CHARACTERISTICS:

(A) LENGTH: 461 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 661:

GAATTCGGCC TTCATGGCCT AGTGGAACTG AAAACT CAG A GGAGGCATCA AACCCAGGCT 6 0

TGGGGGACAA AACTAAGTCT TGCCAGAGTC CTGAAGGATG AACAACAGTT AACCAAGCAA 120
GGGATACTGG AGGGCATGGA GGCTCTCTGG CCTGGAGTGC AGAGCATGGA GTGCTCAAAG 180

310

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AGCTAGTTAG CTCTGCAAAG CTGAGTGTCA GGAATGTAAA GGGAGAGAAT AGGAGTGAGA 24 0

GAAGAGTCTG GCAAGGCAGA CAGGGAAGGC CTATATGCCT TGATGGAGAA CCACTGAAGG 3 00

ATTTAAAGAA GGAGAGGGTT AATTTTGTCC AATAGAAAGA TCACATTGTG TGTAGTGTGG 360

AGGATGGGTT GCAGAGAGAG AAGCTAGAGA CCAAAAGATG AGACGGGAAC AGCTGCAAAT 4 20

TTCGAGAGCT CGTAAGATTA TGTATGGCTG GACCACTCGA G 461

(2) INFORMATION FOR SEQ ID NO:662:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 502 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 662:

GAATTCGGCC TTCATGGCCT AGCCTGAGCT CAGGAGTTCA AGACCAGCCT GGGCAACACA 60

GTGAAACTCC ATCTCTACTA AAATACATAA AAATTAGCTG GGCCTGGAGG CATGCACCTG 12 0

TGGTCCCAGT GCTACTGGGG AGGCTGAGGC AGGAGAATTG CTTGGGCCCG GGAGGCAGAG 180

GTTGCAGTGA GCCAAGATCG CGCCACTGCA CTCCAGCCTG GGCAACAGAG CGAG ACT CCA 24 0

TCTCAAACAA ACAAACAAAC AAACAAACAA ACAAAACAAC AGTTATTTTT TTCTCACCAT 300

TCTAAAGAAT GTTACATTTG ATTCTTTTTC AAAATTTGGT CAGTTTTGAT AGTCTTATTT 360

CTCCATACTT TCATTCCCCC TTTTTATTTC TGTAAATAAT TGAACTTTAT ATTCCTTATA 420

TGATAATTTT AATATCCAAA GTCATTGGTC ATATTCTCCA GTTCATGATT TCTGCTGAGT 4 80

TTGTGGTGCT GATTTTCTCG AG 502

(2) INFORMATION FOR SEQ ID NO: 663:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 485 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:663:

GAATTCGGCC TTCATGGCCT ACAACCACCA ACATTTGTGT TTTTG CAGAT GAACAGGTTG 6 0

ACAGAAGTCC CACTGGCTCA GGAGTGACAG CCCGAATTGC CTTACAGTAT CACAAAGGGC 120

TTCTGGAACT GAACCAGATG AGAGCCTTCA AAAG CAGTGC AACTGG CTCA GTATTCACAG 180

GGAAAGCTGT GAGGGTAAGT GGCACCCTTA GCTTCTTATT TATAAATGTG TCACTCATGA 240

GACTGGAGAG GCCTGAGTTG GGTGTTTGAT AAATTTCTTC ACTCAGCTCT CAGAAGAGAA 300

TTTTAAAGCA GGCCTGTAAA AACTTCTTTT CAACTAGGAC ATTGGTTATC CAGTGTGGTC 360
TTGGGGCCCC AGCGGGCCCC TAAGGTCCTT TCCATGGGTT CAGAGGGTCA AAACTGTGTT . 420

CATAATAATG ACATTATTTG CTTTTCACTC TCATTCTCTC AAGAGTGTAC AGTGGGTTAC 48 0

TCGAG 485

(2) INFORMATION FOR SEQ ID NO: 664:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 348 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

311

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PCT/US98/06956

(xi) SEQUENCE DESCRIPTION : SEQ ID NO; 664;

GAATTCGGCC TTCATGGCCT AAAAATTATA AAGTGTAAAA TATCTTTGTA TCTCTAGTTT

TTCTCCTTTC CCCAGATAAG AATAAAAG CA GGCTGCAGGC TCCTGGGGTG ATAACCCACT

TGGGTCGAGT TCCATCGCTG TTGGCGATAA ATCTTGTTGG TGTTCACTTT TTGGGTTCTC

ACTACCTTTA TGAGCTATAA CACTCACCCT GAAGGTCTGC AGCTTCACTC CTGAAGCCAG

CGAGAGTACG AACCCACAGG CAGGAAGAAA CTCTGAACAC ATCCGAACAT TGGAAAGAAC

AAACTCCAAA CAAGCCGCTT TTAAGAACTG TAACACTCAC AACTCGAG

60
120
180
240
300
348

(2) INFORMATION FOR SEQ ID NO: 665;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 571 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 665:

GAATTCGGCC TTCATGGCCT AGTCGTTATC AG AGG TGG AG ACATTTAGAA GTTGTTCTTA 60

ATCAGAGTGA AG CTTGTGCT TCGGAAAGTC AACCTCACTC CTCAGCACTC ACAG CACCTA 120

GCTCTCCAGG TTCCTCATGG ATGAAGAAGG ACCAGCCCAC ATTTACCCTC CGACAAGTTG 180

GCATAATATG TGAGCG CCTC TTAAAAGACT ATGAAGATAA AATTCG GG AG GAGTATGAGC 240

AAATCCTCAA TAC CAAACTA GCAGAACAAT ATGAATCTTT TGTGAAATTC ACACATGATC 3 00

AGATTATGCG ACGGTATGGG ACAAGGCCAA CAAG CTATGT GTCATGAAGC TTTGTCACAT 360

ATCTGGGTAC CAGGTTTGAC CT CAAGAG AT GGCTGCTGTA CACTTTTTGC AACTGGTTTG 420

ATGTCACATT TCAGCTCCAA CTTTGCATCC TGAGAACACT TAAACGTTTC TGCAGGTCCA 480

TTTTATACAA CTTGAAAGAC CGTAAAACTT TCTGGTTGCC ACAAGCATAT CTTTCTTTTC 540

TGCTCATCCA ATAAACAG CT GAGCCCTCGA G 571

(2) INFORMATION FOR SEQ ID NO: 666:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:666:

GGGATCATTA TTATTCAG CT ACTGAGAACT AGAATATTAA GAGA.CTGCTG GCAAGGCAAG 6 0

CAGTTAATTT TCAGTTGAAA TTGCATTAAA TAAAAAGTAT TTTCTTGCTT TGTGGAAGCA 120

CGTGAATTTT TGTAAAAAGC TGCTTGTTTT CCCCATTTAC AGGTTCTGTA CAG AG TAATG 180

AGATGTGTGA CGGCTGCAAA CCAGGTGTTT TTTTCTGAGG CTGTGTTGAC AGCTGCTAAT 24 0

GAGTGTGTTG GTGTTTTGCT CGGCAGCTTG AATCCTAGCA TGACTATACA TTGTGACATG 3 00

GTCATTACAT ATGGATTAGA CCAACTGGAG AATTGC CAGA CTTGTGGTAC CAATTATATC 360

ATCTCAGTCT TGAATTTACT CACGCTGGTA TGTGAATTAT TCTTTTCCTT TTTAATGTGT 420

TGGTTTATTC AGGCCCATCT CGAG 44 4

(2) INFORMATION FOR SEQ ID NO: 667:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 524 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

312

WO 98/45437 PCT/US98/06956

(D) TOPOLOGY: linear
(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 667:

GGGAACTGAC AAGCAATTAA CTGGAGAATA AGTGAGGGGA ATGGAGCAGT AGTATTCTTT 60

AACTTAATTT GCCATTTAAG AGAGCACTTG GAATCTGAAG AAAGTCTATC CCTACCAAGG 120

AAACGGAGTC AAATTGCAAT TAAGATTAAC TTTGGTTATA TGGAAGCAAG AATCATG CTT 180

CTCATCATCA ATTG CG TCTC TTTGGTAGCC AATAATTCCA TCTGTAATCA TGGCAGCAAC 24 0

TTAAGTATTG CCAATGTTTT CAAATGTGTT ACAGCATTAA GGCATCCACA TCTAAAGAGG 3 00

CAGTTTTAAA CAAGAGGAAA ACGGAACTGA AATGTGCCAA GAAGTGAACA CGGACATGGC 3 60

CTCTCCTGGA ATACTGCCCA CCATGCCAGC AAGCTCTTCC TCCAGTCAAG AAGGCCTGTG 420

CCACGCTGCT TGGTTCCCTG CTGCCTGAAG ATGCATTTGA GCCCTATGAG ATTAGTATGG 4 80

CTATTTCTGT CTGCTGACCA GGAGAGAAAT GAGTAGTTCT CGAG 524

(2) INFORMATION FOR SEQ ID NO: 66 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 554 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 668:

GAATTCGGCC AAAGAGGCCT ACACAGAGGG AT AATTGG CA TTGGTATCAA CTGACATATT 60

CACAACTTTG AATAAAACTT TCCACATTTG GAAAATCACC ATGCCTGGCC CCTAGGCTAT 120

ACTTTGAAAA CCACTGCTTT AGTGTTTTAG AAATTGTTAC CCTCATACTA ATATTTACTA 180

CACCCCCCAC CTTGACAATA CATACAAAAG AGGAGTAACA GTTTCCCATA ACCTTTCTAA 240

ATTTGAGTCT TATTAAACCA GACT CAT AGC CCTTGTTGAC TTTTCTTCCT GATCTGTGCC 3 00

TTAT CCCTAG GGCGGTGATC ATGCGGGTAT CTGCTAATTG GCAGATGTGA GTGGTTATAC 3 60

CTATTTACAA GCAACTCATT GCAAAAATAA TTTTAGCTAA AGAAAACATC CATGGCCAGA 4 20

GAATAAGTTT TGGAATTTGA TATGTTAAAT GAG CTTTATG TTTACCTTTA AAAGGTTAAA 4 80

ATATTTACCA TTCATGGATT ACCTTTTTTC AGAAAGTAAG AATATATAAA TTACATTTAA 54 0 -

TCTTGAAGCT CGAG 554

(2) INFORMATION FOR SEQ ID NO:669:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 29 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 669:

GAATTCGGCC TTCATGGCCT AATCGTATTC CATCTACTGC ATACTTTTCA TAGATGTCCT 6 0

CCATCAGAAG CACCTATGGT TGTTTGTTAA ACGTGTTATT TCCTGATCCC ACCCCAGGAT 12 0

TTCTGAGTAT TCTAAGAATT TCTAAGTGTA AGGCCTGGAA ATATGCATTT TACAACCCCC 180

TAGAACATTC TTATGTGCAC TAAAATTTGA GAACCACTAA TCTGGTGTAT ATACTGTTGT 240

TACTTAATAT TTTCTTAATG ATAGATACTT GGATGATTTT TGACTTTATT ATTATTATAA 3 00

GCAATGTTGT AAACATCACA CAGGCCAAG 329

(2) INFORMATION FOR SEQ ID NO: 670:

313

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 267 base pairs
{B ) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(il) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 70:

GGCGTATGAT ACCTAAAGTG GAGTGGTCGG CGTTCCTGGA GGCGGCCGAT AACTTGCGTC 60

TGATCCAGGT GCCGAAAGGG CCGGTTGAGG GATATGAGGA GAATG AG GAG TTTCTGAGGA 120

CCATGCACCA CCTGCTGCTG GAGGTGGAAG TGATAGAGGG CACCCTGCAG TGCCCGGAAT 180

CTGGACGTAT GTTCCCCATC AGCCGCGGGA TCCCCAACAT GCTGCTGAGT GAAGAGGAAA 24 0

CTGAGAGTTG ATTGCACCAG ACTCGAG 267

(2) INFORMATION FOR SEQ ID NO: 6 71:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 429 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 671:

GAATTCGGCC TTCATGGCCT ATTATCTCTC AAAAACAAAG CAATAAGTAC CAAGAAATAG 60

CAACAAAAAT TAGCTTGTAA GGTTGGTTTC TGAGGGTAGA AATGGCTCTT GATGCCATGT 12 0

GGAGCAAffGG GAAGGAGGCT TTCTAGTTAC ACAGACTCTT GGTCCTGCCA CTTATTCATT 180

TTATTTTATT TTATATTTTA CTTTAAATTT TTTGAGATAG GGTTTCACCC TGTCGCCCAG 240

GCTGGTGGGC AGTGGCTCAC TGCAGCCTCG AACTACCAGG CTGAAGTGAT GCTCTTACCT 300

CAGCCTTTCG AGTAGTTGGG ACAACAGGTG CACACCACCA TTCCTGGCTA ATTAAAAAAA 360

TTTTTTTGTG GGAACATGG C AAGACCTTGT CTCTATTAAC AACAACAG C A ACAGCAACAA 420

CAACTCGAG 429

(2) INFORMATION FOR SEQ ID NO:672:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 57 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:672:

GTAAAATCGT TCTTGAGAGG AACGTCTCTG TGCGAAGAGA TAATGAGTTT AG CTCTGAG A 6 0

AGTGAGCTTG TAGTGGACAA AACAAAGAGG AAAAAAAGAA GAGAACTGTC TGAGGAACAG 120

AAACAAGAAA TTAAAGATGC TTTTGAACTA TTTGATACAG ACAAAGATGA AGCAATAGAT 180

TATCATGAAT TAAAGGTGGC AATGAGAGCC TTGGGGTTTG ATGTAAAAAA AGCTGATGTA 240

CTGAAGATTC TTAAAGATTA TGACAGAGAA GCCACAGGGA AAATCACCTT TGAAGATTTT 3 00

AATGAAGTTG TGACAGACTG GATATTGGAA AG AGATC CCC ATGAAGAAAT ACTCGAG 3 57

(2) INFORMATION FOR SEQ ID NO: 673:

(i) SEQUENCE CHARACTERISTICS:

314

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(A) LENGTH: 2 92 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NQ:673:

GGTAGATACT GGTTTTTCGT ATCCTGCTTC TCTTAAGGGC AGCTCTTTTT AGCATACTCC 6 0

CATGCAGCAA CAGAAATTTG TATCTTTTTT TTCTTTTTTG AGATGGAGTC TCGCTCTATC 12 0

ACTAGGCTGG AGTGCAGTGG CACAATCTCG GCTCACTGCA ACCTCTGCCT CCTGGTTCAA 180

GCGATTCTCC TGCCCTAGCC TCCTGAGTAC CTGGGACTAC AGGTGCGCGC CACCACACCC 24 0

AGCTAATTTT TATATTTTTA GTAGAGACGG GGTTTTACCA TGTGGCCTCG AG 292

(2) INFORMATION FOR SEQ ID NO: 674:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 470 base pairs

(B) TYPE: nucleic acid.

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:674:

GGATGGACAT CAGCACTTTA CGGCGCCAGC TGAGACCCAC AGGCCAGCTC CGTGGAGGGC 60

TCAAGGGCTC CAAGAGTGAG GATTCGGAGC TGCCCCCGCA GACGGCCTCC GAGGCTCCCA 120

GTGAGGGGTC TAGGAGAAGC TCATCCGACC TCATCACCCT CCCAGCCACC ACTCCCCCAT 180

GTCCCACCAA GAAGGAATGG GAAGGGCCAG CCACCTCGTA CATGACATGC AGCGCCTACC 24 0

AGAAGGTCCA GGACTCGGAG ATCAGCTTCC CCGCGGGCGT GGAGGTG CAG GTGCTGGAGA 300

AGCAGGAGAG CGGGTGGTGG TATGTGAGGT TTGGGGAGCT GGAGGGCTGG GCCCCTTCCC 360

ACTATTTGGT G CTGGATG AG AACGAGCAAC CTGACCCCTC TGG CAAAG AG CTGGACACAG 420

TGCCCGCCAA GGGCAGGCAG AACGAAGGCA AGTCAGACAT CCAACTCGAG 4 70

(2) INFORMATION FOR SEQ ID NO: 675:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 637 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:675:

GAATTCGGCC AAAGAGGCCT AGTCGCTCTT GCTGAAACCT TCAATGCAGT GAGCGCCCAT 6 0

CTCATTGGGA CCTACAGGCT GAAGTTCTTC CTCTGATGGA CATGACCCCC GTGTTGTCTC 120

TAATAACCTC ACTTTCACTC TGTTCCAGCC ACACGGGGTT TCTGTCTTTC TCGGGTCATG 180

TCGGGCTTAT GTGCCTCGGG CCCTTTGCTC ATGCTGTTCT CTGCCTGGGA TGCGCTTTAC 240

TGGGTGCCAG GATGGTCAGT GATTCCATTT CTCTCAGAGT CTATTCACAG GTCCCCTTCT 3 00

CGGTCACGCC TTCTCTGGCT CCACTGTCTA AAATTTCAAC AGCTGCCTCT GCCCCCCGAA 360

CTTCATATCC CCCTTATCTG CCTTTTTTCC TTCAGCTCTT ACTTCCATCA AATACAGTAT 4 20

GTATTTTTAA AAGTCTTATC TTGTTCACGG TCATTTTCTT CCACAGGTAA TTTTGGTAAA 4 80

CTTTGTAAGA TTGATGATGT TTAATACTGT TTTGTTTAAT ACAGTACCCC CAGTTTAGCA 54 0

CACAGCTTTT G AATGAATG A CCAGTTTTTA TTCCCCTCTG AAGCGCTAAG AGCTGCCGCT 600

GAGGTGGCAT CTGTAGCNGC TCCCGCTCCA ACTCGAG 63 7

315

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(2) INFORMATION FOR SEQ ID NO: 6 76:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 513 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 676:

GAACACGTCA TGAGGAAGGA GCAGCGCAAG GAGGAGAAGG AGAAGCGGCG CCTCGACCAG 60

CTGGAACGTA AGAAGGAGAC GCAGCGCCTA CTGGAGGAGG AGGACTCCAA GCTCAAGGGC 120

GGCAAGGCGC CGCGGGTGGC CACGTCCAGC AAGGTCACCC GGGCCCAGAT CGAGGACACG 180

CTGCGCCGAG ACCATCAGCT CAGGGAGGCC CCGGACACAG CCGAGAAAGC CAAGAGCCAT 240

CTGGAGGTGC CGCTGGAGGA GAACGTGAAC CGCCGCGTGC TGGAGGAGGG CAG CGTGG AG 3 00

GCGCGCACCA TCGAGGACGC CATTGCAGTG CTCAGCGTGG CGGAGGAGGC GGCCGACCGG 3 60

C AC C CAG AAA GACGCATGCG GGCAGCCTTC ACAGCCTTTG AGGAAGCCCA GCTGCCGCGG 4 20

CTCAAACAAG AGAACCCCAA CATGCGGCTG TCGCAGCTGA AACAGCTGCT CAAGAAGGAG 4 80

TGGCTCCGCT CTCCTGACAA CCCCAAACTC GAG 513

(2) INFORMATION FOR SEQ ID NO: 677:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 376 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:677:

GTCCATCCTG AGCTCCATGG AGAAGCCACC CAGCCTCGGT GACCAGGAGA CTCGGCGCAA 60

GGCCCGAGAA CAGGCCGCCC GCCTGAAGAA ACTACAAGAG CAAGAGAAAC AACAGAAAGT 12 0

GGAGTTTCGT AAAAGGATGG AGAAGGAGGT GTCAGATTTC ATTCAAGACA GTGGGCAGAT 180

CAAGAAAAAG TTTCAGCCAA TGAACAAGAT CGAGAGGAGC ATACTACATG ATGTGGTGGA 240

AGTGGCTGGC CTGACATCCT TCTCCTTTGG GGAAGATGAT GACTGTCGCT ATGT C ATGAT 3 00

CTTCAAAAAG GAGTTTGCAC CCTCAGATGA AGAGCTAGAC TCTTACCGTC GTGGAGAGGA 360

ATGGGCCCCC CTCGAG 376

(2) INFORMATION FOR SEQ ID NO: 678:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 678:

GAATTCGGCC TTCATGCCTA GCAGGAGGTT TTATTGTAAA GAGGCCGATT GTACAGAGCA 60

AAGATTGTTC TGACACGGGG GGCTGGGTGG TGGGACCCAG AGGCCAGAGC TGGGTGAAGG 12 0

ATGAGGGGTG GCATCGCCCC ATCCAGGCAG TGGGCAGGGC AGGGAGGACT AAACGGCTGC 1B0

CTCCCAGTTC CCTTCCCTGC CCCTCATTAC TGGGTAAGAG GGAGCCAGGC TATTTCCACG 24 0

GATCCAGGAG AATATAG CAG GAGACCCTCA CCACCCCACA CCATGCCCCA AGGATACGGG 300

316

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AGGTGCCCCA GTCTGGCTTT TGCAGTCGGC CAGCTCCCAG CCTCCTCGAG 3 50

(2) INFORMATION FOR SEQ ID NO: 679:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH t 3 57 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 679:

GAATTCGGCC TTCATGGCCT AGTTCTCACC GGGGAAAAAC CCACTGTTAG GATGGCATGA 60

ACATTTCCTT AGATCGTGGT CAGCTCCGAG GAATGTGGCG TCCAGGCTCT TTGAGAGCCA 120

TGGGCTGCAC CCGGCCGTAG GCTAGTGTAA CTCGCATCCC ATTGCAGTGC CGTTTCTTGA 180

CTGTGTTGCT GTCTCTTA~A TTAACCGTGC TGAGGCTCCA CATAGCTCCT GGACCTGTGT 24 0

CTAGTACATA CTGAAGCGAT GGTCAGAGTG TGTAGAGTGA AGTTGCTGTG CCCACATTGT 300

TTGAACTCGC GTACCCCGTA GATACATTGT GCAACGTTCT TCTGTTATTC CCTCGAG 3 57

(2) INFORMATION FOR SEQ ID NO: 68 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 80:

GGGGGTGGAA GGCGTAGTGC TTGAAATGCA GGGATCTGGC AGT CAGCAGA AGGATCTGAG 60

ACCCAGTGTC GAGGTTAAAA AAAAAACAAA AAACCAAAAA CCAATGCAGG AATC CAGTGG 120

GTGGAGTGAG GGGATCTGGG ATCCAGTGAT GGGGGCCCCA GGATCCAGGC ATTGTGGTTG 180

TCAGGATCCA GTGGTGAGGT TTGTTGACAT CCAGAATCCA GCAGCTGAGC TTGGAGATCC 240

AGGGCTCGAG 2 50

(2) INFORMATION FOR SEQ ID NO: 681:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 406 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 681:

GGATTCCTAC AAAAATTGAG GCAGAAGATC AAAAT CGG AG TGGTAGGCGG ATCGGACTTT 60

GAGAAAGTGC AGGAGCAACT GGGAAATGAT GAATATTCAA AGTCATCTGG GTGAGGCCCT 12 G

AATCCAAGAT TTAATCAACT ACTGTCTGAG CTACATTGCG AAAATTAAAC TCCCGAAGAA 180

GAGGGGTACT TTCATTGAAT TCCGAAATGG GATGTTAAAC GTGTCCCCTA TTGGAAGAAG 240

CTGCAGCCAA GAAGAACGCA TTGAGTTCTA CGAACTCGAT AAAAAAGAAA ATATAAGACA 3 00

AAAGTTTGTA GCAGATCTAC GGAAAGAGTT TGCTGGAAAA GGCCTCACGT TTTCCATAGG 360

AG GCCAG ATC AGCTTTGATG TCTTTCCTGA TGGATGGAAA CTCGAG 406

317

(2) INFORMATION FOR SEQ ID NO: 682;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 316 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 82:

GAATTCGGCC TTCATGGCCT ACCCTTCTAG GTGTCATCTC CTTCCCTCCC TTTCCCCCAA
GACTCCCTCT GGGCCCAGCC AG CAGGTGAA GCCTGACTTA GGGAAGGGGG GATTTCCAGG
GGAGGGGCCC TGGCCCCCAC TGACCCAGCA TTGCTATCCA CAGGAGGAGC AGCCCCCACA
ACATCGATCC AAGAGGGGGG GCTCAGTGGG CGGCGTGTGC TACCTGTCGA TGGGCATGGT
CGTGCTGCTC ATGGGCCTCG TGTTCGCCTC TGTCTACATC TACAGATACT TCTTCCTTGC
GCAGCTGTCC CTCGAG

(2) INFORMATION FOR SEQ ID NO: 6 83:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 94 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 83:

GAATTCGGCC TTCATGGCCT AATTGAATTC TAGACCTGCC TCGGCCTCCC AAAGTGCTGG

GATTACAGGT GTGAGCTAGC ACTCCCAGCC GACAGGTGCT TCTTAAATGT TTTCTTTGAG

CAGGAATTGG TCCAGGAATT GGTTCTCAAG TTAGAAGGAA AATTTGAGGG GAAGAACTTG

TTTTTTCTCC AATCAGTCTC TGATTAAATA GTTATTAGGA AAAACTCCTT GCTTATGTCT
TTGTATTGCA CATTTTTATA TATGTATATA TGTGTAAATA GAGATATTTA TATATTCACA

GACAAACACG TGTATGCACA TTTCACAATG GAGGAAGAAG GGATATGGTG TGCACTGAGG

TAAAGTGAGC AGGGATACAG AAGAGAAACT CGAG

(2) INFORMATION FOR SEQ ID NO: 6 84:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: SO 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 84:

GTCCTAACCT TGGGTCCAAG TTTCGTTATA GTGGCAGGAC ACAAGCGCAA ACGAGAAGAG
CCAGTGCGTT GATAGATCGC CCAGCACCTT ACTTTGAACG CTCATCCAGC AAACGTTATA
CCATGTCTCG CAGCTTGGAT GGAGCATCAG TGAATGAAAA CCATGAAATA TACATGAAGG
ATT CTATGTC TGCTGCAGAG GTTGGTACTG GCCAGTACGC CACAACAAAA GGCATCTCTC
AGACCAACTT GATCACCACT GTGACTCCGG AGAAGAAGGC TGAGGAGGAG CGGGACGAGG
AAGAGGACAA ACGGAGGAAG GGGGAAGAAG TCACGCCCAT CTCGGCCATC CGGGACGAGG
GAAAGACTGA CAGTGAGCGC ACGGACACCG CAGCCGACGG GGAGACCACC GCCACTGAGT
CGGACCAGGA GGAAGATGCA GAG CTCAAGG CACAGGAGCT AGAAAAAACT CAAGATGACC

318

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TGATGAAACA TCAAACCAAC ATTCTCGAG 509
(2) INFORMATION FOR SEQ ID NO: 6 85:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
{ D ) TOPOLOGY : 1 inear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 685:

GAATTCGGCC TTCATGGCCT ACCAAAGTGC TAGGATTACA GGCGTGAGCC ACTGCGCCTG 60

GCCTCTTTCT TCTTTCTTGA ATTCTCTTCT TTTTATGTTC CTGGGAAAAT CCTACTCATT 120

TTATATGATT TGGCTGATGT AAAGCCACCA TTGTCTTCCT AAGCAGAGAG GGTCTTGCTT 180

TTGGGTGCTG CACAACTTTG TGCAATTTTT CTGTTACATC ATTTATCTTT TGGGGATTGT 24 0

TTATTTTCAT ACTTATCTCT CTTCCAGGAC CATGTTAGGG AGAGGTGTTT TTAATTTTTA 300

CCTTTTCTGC AGCACTTAGC ACAGTGCCTA ATCATAGTAA ATATCACGTA AAAGTTGAAT 360

GAAGGAATGG ATGTTTGATA TAGAGTTAGG ACACCTGTGT CCAGGTCTGG CTTTGCTTTT 420

CCTTTNACCC CCCACCTCGA G 441

(2) INFORMATION FOR SEQ ID NO: 6 86:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 273 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 86:

GAATTCGGCC TTCATGGCCT AGTTGGTTTA TGTTATGTAA AGTTATGTAG TTATGTAAAG 60

GTG CTGAAAT GTCACTCTTG TGATTATGTT TTATTATATA AGGCTCTATC TTAG CAAACC 120 .

AGGAGAGAAA TTCTCCTGAT GGCCTTGAAG AAGCAAACAG CCACCTGGTT AAGCCCCTGT 180

GGATAGTGCC AAGTGG CAGG AAAGTGGGAG CCACCTCTAG GACCTGAGGA TTAAAGTCAG 24 0

TAAGAGCTGG GACCTCACTC ATGCAG ACT C GAG 273

(2) INFORMATION FOR SEQ ID NO: 6 87:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 124 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 687 :

GAATTCGGCC AAAGAGGCCT AGGGCTCTGG ATTTTGAGTT TCGGGCTCTA GATGGAATTG 60

AGAAGGTCCA ACTTGCTCAG AGGGCCCTGG AGGCTCATCT GACTTCACCC GGATTTTCCT 120

CGAG 124

(2) INFORMATION FOR SEQ ID NO: 688:

319

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PCT/US98/06956

<i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 688:

GAATTCGGCC AAAGAGGCCT ATGCCATCTT AGTCCCTCTT CCCAACCCCA TTTTTTAGTT 60

ACTTTCCTTT CATTAAAATA TCCTTATGCA CTTACAAATA AAACTAAGTC C CAAGAGGG C 120

AACAAAATAT AAGATTCTTA ATGATACAAA AACAAATCTT TCTGATACTA GATCTTTTAT 18 0

ACTAGAAAAA TAAATTCTTG TGCTTGAACA TCATTTTTAA GCACTTAGTG AATTGAGAAT 24 0

CTGAACTGCC ACTTGAAATA TTCCCGGGAA AGAAACATTA TGAACCAAAT GAAGGAACAT 3 00

AGCTATTCAA AGGGACATAT TTTTGTACTT GTTTTGCTCC AATTTCTGCT ACATAGACTG 3 60

CTCCAGTCTT TCTGTCGACT CTAGGAGATG CCTAAACCGT CGATTGAATT CTAGACCTGC 4 20

CTCGAG 426

(2) INFORMATION FOR SEQ ID NO: 689:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 05 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 689:

GAATTCGGCC AAAGAGGCCT ATAGTTTTTT CATGTTACAT CTTTTAGATT ATTTTCTTTT 60

TAATCTATCT GTGACTATAT TTAAAGTCAA TTCTTGTTTT TTCCTTTTCC TTTTTGTGGG 120

TAACGGGGTC TCGCTGTGTT GCCCAGGCAG ATCTCAAACT CCTGGGCTCA AGCTGTCCTC 180

CCACC.TCTGC CACCCTAGGC TCGAG 20 5

(2) INFORMATION FOR SEQ ID NO: 6 90:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 90:

GAATTCGGCC AAAGAGGCCT ACGTTGATTG AG CACTGAGC CCTTACTACG TGCTAGGCAT 60
GGTACATGCA TGGCCTTATT TAATCCTATC AACC CTCGAG 100

(2) INFORMATION FOR SEQ ID NO: 691:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 02 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

320

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(ii) MOLECULE TYPE: cDNA

Ui)' SEQUENCE DESCRIPTION: SEQ ID NO: 6 91:

GAATTCGGCC AAAGAGGCCT ACATCATACA AGTCGTCGTA AAGCAAATCT GAGCTGTTGT 6 0

CATTGGAAGG CACTTTAGTT TTGATGCAGT ATTCCGCCAG GGTTGTGGGG ACCTTCACTC 120

CATCCTTTTC TGCTTCGGCC TTAGTGGCTG AAACTTGTTT CCTAATAATT TCAGCATATT 180

CTTTGTCTTT TCCTTTACTG TCTCTCCATT TCCTGAACAT AACTGAAGCA TCGACATTGG 240

CTGGGGAGAA GGTGTTGGGC TCATTAAGCA GTGAGATTAC ACTTAATAGG ATAGTCCTCG 300

AG 302

(2) INFORMATION FOR SEQ ID NO: 6 92:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 662 base pairs

(B) TYPE: nucleic acid
<C) STRAND EDNESS : double
<D> TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 692 :

GAATTCGGCC AAAGAGGCCT AC CAAATACC AGGCTACCAT GGTCTACAAG ACTCTCTTCG 60

CTCTTTGCAT CTTAACTGCA GGATGG AG GG TACAGAGTCT GCCTACATCA GCTCCTTTGT 12 0

CTGTTTCTCT TCCGACAAAC ATTGTACCAC CGACCACCAT CTGGACTAGC TCTCCACAAA 180

ACACTGATGC AGACACTGCC TCCCCATCCA ACGGCACTCA CAACAACTCG GTGCTCCCAG 240

TTACAGCATC AGCCCCAACA TCTCTGCTTC CTAAGAACAT TTCCATAGAG TCCAGAGAAG 300

AGGAGATCAC CAGCCCAGGT TCGAATTGGG AAGGCACAAA CACAGACCCC TCACCTTCTG 36 0

GGTTCTCGTC AACAAGCGGT GGAGTCCACT TAACAACCAC GTTGGAGGAA CACAGCTCGG 42 0

GCACTCCTGA AGCAGGCGTG GCAGCTACAC TGTCGCAGTC CGCTGCTGAG CCTCCCACAC 480

TCATCTCCCC TCAAGCTCCA GCCTCATCAC CCTCATCCCT ATCAACCTCA CCACCTGAGG 54 0

TCTTTTCTGC CTCCGTTACT ACCAACCATA GCTCCACTGT GACCAGCACC CAACCCACTG 600

GAGCTCCAAC TGCACCAGAG TCCCCGACAG AGGAGTCCAG CTCTGACCAC ACGACCCTCG 660

AG 662

(2) INFORMATION FOR SEQ ID NO; 6 93:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 321 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 93 :

GAATTCGGCC AAAGAGGCCT AAGCCCCCAA AACACGCTCT TTTGTGCCTC CCCTCAAATC 60

CTTCACAGTG TTCTTCCATA TCCACTCCTT CCAGGAAGCA TGTTCTCACT ACCCCAGTTC 120

ATGTGGGTTT CTTCCCTCTC AGAATTTCTA TCATGCCCCT ATAAG TTTAG CAAATTGTCC 180

TTCTCTAATT GTTTCACATC TGTCCATCCG ATATCCCAGG AGGACTGTCA GCTCTATGAA 240

GGCAGGGGTT GTCTTTCCTT TACCATGCCT ACCATGCCTT ATAGTGTTAA TAAATTAACC 3 00

T ACC CAG AAA TGTTTCTCGA G 321

(2) INFORMATION FOR SEQ ID NO: 694:

<i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 357 base pairs

321

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(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 94:

GCGATTGAAT TCTAGACCTG CCTCAATCCC CTCCCTACTT GCTTTTTCTT AG C AT ATAAA 6 0

AGTCCACAAG TTTTACTCAT CTTTTTAAAA AACGAAAACA TCCTTAGACC GTGTCCTCCA 12 0

TTAGTTGCTA TCCTGCCTTC TTCTCTCAGC TGAGCTGTCT GAAACATGCT AACATGCTTA 18 0

TACAATACTT GCTGTCCTGC CTTCTGCTCT CAGCTGAGCT CTCTGAAACA TGCTAACATG 24 0

CTTATACAAT ACTTGCTGTC CTGCCTTCTC CTCTCAGCTG AGCTCTCTGG AACATGCTTT 3 00

TTATACAATA CTTGCTGTCC TGCCTTCTTC TCTCAGCTGA GCTCTCTGGA ACTCGAG 3 57

(2) INFORMATION FOR SEQ ID NO: 6 95:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 225 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 695:

GAATTCGGCC AAAGAGGCCT ATGGGTTTTT AAAAATTTTG TTTTTATTTT TTCCTTTGAT 6 0

GTGCAGAGGC TGTTTACTTT GATGCAGTCT CACTTGTTTA TATTTTATTT TGTTGCTGGC 12 0

CTAGGCCTCT TTGGCCGAAT TCGGCCAAAG AGGCCTAGTC GGGTGTGGCA GTGCCATTCT 180

GCAGTCCCAG CCACCGGGAA GACCGAAGCG GGAGGATCAC TCGAG 225

(2) INFORMATION FOR SEQ ID NO: 696:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 314 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 96:

GAATTCGGCC AAAGAGGCCT ATCCGCTTCT GTTGCAGCTG GCGGTGCTCG GCGCGGCGCT 60

GGCGGCCGCA GCCCTCGTAC TGATTTCCAT CGTTGCATTT ACAACTGCTA CAAAAATGCC 120

AGCACTCCAT CGACATGAAG AAGAGAAATT CTTCTTAAAT GCCAAAGGCC AGAAAGAAAC ISO

TTTACCCAGC ATGGGACTCA CCTACCAAAC AACTTTCTGT CGTTGTGCCT TCAAACAATG 24 0

AAGAAAAACG GTTGCCTGTG ATGATGGATG AAGCT CTGAG CTATGTAGAG AAGAGACAGA 3 00

AACGAGACCT CGAG 314

(2) INFORMATION FOR SEQ ID NO: 6 97:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 53 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

322

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 697:

GAATTCGGCC TTCATGGCCT ACAGAGTGTG GACGGCCCAC TGGGTTGGTG GTGGTGGGTG 6 0

CCCGTCACAG GGCTGGAGGT GTGGCCGGCC CACTGGGTTG TGCTTTCTGC CGTACGTCCC 120

TTCCCATGAG GATGAGATGA CCCATCTGTT GCATCCCGGC TGCTGATAAA ACAAGACCCT 180

CGGAGCCAAG AAACAACACT GAGTTCCAGA TTTCGGAAGG TTCACGAGTG TTGCCGACAC 24 0

GCCCTCCCAA CTG CAGACAT CCTCCCTGGA GGACCTGCTG TGCTCACATG CCCCCCTGTC 3 00

CAG CGAGGAC GACACCTCCC CGGGCTGTGC AGCCCCCTCC CAGGCCCCTC GAG 3 53

(2) INFORMATION FOR SEQ ID NO: 6 98:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 44 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6 98:

GAATTCGGCC TTCATGGCCT AGATTGACAG AGGTCAGTTG TCACTTCTTG CCTCTCTCCC 6 0

CTTCCAGCAA CATGTATAAT CCTGTGAGTG TTTCTTCAGC ACCCTTCTCT GTTGTTTACA 120

CTACTGCAAG AGCCTCCCTA AGTGGTCTGC CTGTTTCCAC CCTGTTGTCT TGGAATTTAG 180

TTTTCTCGCA AAAGCCAGAG AATGTTTTCA GAAGGTAGCT CTTGAGCAAC TTCCCACTTT 24 0

CTTGGAGGGG AGATCCAGCT TCCCCAACAA GACCAGCAGG CCCCTGTGCG GCCTGGCTCC 3 00

TGTTCACCCT ACCAGTCTTG GCTCAGGCTC ACGGCTGGAA TATGCCGAGC TCTTTCTTGT 360

CCTGGGGCCT TTGCACTTGG CTTCCCTCTG TCCAAAATCA TCTTCCTGTA GCTTTGTGCT 420

TGCCTAGCTC ATCATCATAG CAGCTCGAG 44 9

(2) INFORMATION FOR SEQ ID NO: 699:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
{ D ) TOPOLOGY : 1 inear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 699:

GAATTCGGCC TTCATGGCCT ACAGAGAACT GAGGAAAACC AACTACGTGG AGAAT CTCAA 6 0

AGAAAAAAGC GAGGGAGAAG CTTCACTGTA TGAAGATAGA ATAATAACAA GAGAGAAGGA 120

CATGAGGAGA GTGAGAGATG AG CCCG AGAA GGTGGTGAAG CAGTGGGACC ATAGTGAGGA 180

TGAGAAAGAG ACAGATGAGG ACGATGAGGC TTTTGGGGAA GCTCTGCAGA G C CCAGCAAG 24 0

CGGAAAGCAG AGTGTGGAAG CAGGAAAAGC CAGAAG CG AT TTGGGAGCAG TTGCCAAGGG 3 00

CCTGTCAGGA GAATTAGGCA CAAGATCAAG AGGGCTCGAG 340

(2) INFORMATION FOR SEQ ID NO: 700:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 80 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

323

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(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 700:

GAATTCGGCC TTCATGGCCT AAGCCAAGCA AGGCTGTACC TTTAATTACT GCTGCCCTCA 6 0

TTTGCATCTG GCTGCCCTCA TTATAGTGCT ATTAGCAGAG TGCAGGGGTC CTCCTGCTGG 120

CCCATCGGGA GTGGTGCGTG CACAGTTGTG GGGCCTTGCT TTGGTGGTCT TTGCTGCCTT 180

CTGGG CAAAA TGAAGGATTT GGAGTAGACA GCAAGCAGGC ATACATCCTG GGCCAGAAGC 24 0

AGCCTGCGGA GCTCATCGTG GCTTGCCTTA AATTGTTTCT CAACAATAAA GTTGTTGAAA 3 00

AACAATTTGT GTTTTCTTTC TCCTTATTAA AAACC CAAAA T TAT ATT CAT TATAGAAAAT 3 60

TAAAGAAGAT AGCTCTCGAG 380

(2) INFORMATION FOR SEQ ID NO : 701 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 319 base pairs

(B) TYPE: nucleic acid

N (C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:701:

GAATTCGGCC TTCATGGCCT AATTGAATTC TAG AC CTGC C TCAGCCTCCC AAAGTG CTGG 60

GATTATAGGC GTGAGCCACC GCGCCCAGCC GAAAATCTAA AGATATTGAA AAGATACAAA 12 0

GGAGCACATT ATGAACATTT TTTTCGTATC ACTGAGTATT TTATAACTGC AT GATTGATT 180

TTAAAAGAAT T CATGACTTT GAAAACTAAT ATTCTACAAA GTAG CTTTTG ATTTAACATG 24 0

AGATTTTATA TATGTG CTTA TCTTGGTTCT CTATGAAACC CCATTGAAAT AAGAAAATGT 3 00

AAACACCAGC CAACTCGAG 319

(2) INFORMATION FOR SEQ ID NO : 702 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 9 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 702:

GAATTCGGCC AAAGAGGCCT AATAGT CAAG ACCTTTGCAG TTTTGAT C AC AGAAATATGA 60

AAGATTACAC AGCTACAGCT ATATGAATGA TAAAAGTGAC AG CTATGG AT TTTTAAAGTT 120

ATAAGTTGCT ATACTACATA TATGTAATGT GTGTGTGTAT AGTGTGTAGG TATATATATT 180

TATATTTATA CACACACTAT ACATGTATTT TAAAATATTG AAAAT CCAGA ATTATTTTAT 24 0

GGTAAAAATT ACTAAAATTG ACTTCACATG CTGAATGAAG AGAGCCTGAG TAGACCAACA 3 00

AACAAATGAA AAATTAAGAC GGT TAGAAGA TACGCTTTCT AAAAGAATAC ATTTAGAATC 3 60

TAACTTTAAA AAAAAAAAAT CCTACTCTCC TGAGCCAGAG TGGTCTCAGA GAGACTCCGA 42 0

GAACC TAATT TTTTACAAGT AAAATCTTTG AAGAATTGGT AATTGCTAAA TTTTTCCAAC 4 80

ATACTATTCT ACAAGACTAA CCTAAAACTG ATTATAAGAA CTAGGTGAGG AGGGCCGGCA 540

AAACTCGAG 549

(2) INFORMATION FOR SEQ ID NO: 703:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 758 base pairs

(B) TYPE: nucleic acid

324

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(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 70 3:

GAATTCGGCC AAAGAGGCCT ATCGAGCCAC TGCACCTGGC CGATGTGTTC TGTTTGAAAT 6 0

CTTACTCAAA AGTATTTGAA GAGTTGTGTA TAGTTGTATG GATATGTCTG TAGTAAACAG 12 0

AAACAAATTG CTTCAGTTTC TCTTTACTTA TTTTCTAGGT TACAGTACCT TTACCAGCAT 18 0

CCCAGCTTTC CTTGCCTAAT TTTGGATCTA CAGGGCAACC TCTAATTGCT TTGCCTCAGA 24 0

CTCTTCAGCC C CCATTAC AG CATACCACTC CCCAAGCACA GGCTCAGAGT CTGAGTCGTC 30 0

CTGCACAAGT AAGCCAGCCT TTCAGAGGAT TAATTCCTGC TGGAACACAG CATAGCATGA 36 0

TTGCAACCAC CGGAAAAGTA AGTAAAGAGA CATTTGCACA GGTTATTTGA GAATTTAAGG 420

TAGTGTGTTC AGATATATGC ATCTGTGTTA TCTAAAAAAC TAAAATGCGT CAGTTTTTAC 480

CACCCTGCAA AAATCTCAAA CCCCAGTATA TTTACATTTT ATCTATTTAC TTTTAATGTG 54 0

TTTGGCCCCA TCTAGTTTTT AC CTAAT AAC AAAGAATT C A CAAATTTATT GGAAGAATTG 600

GATTTATAGT GTCTCTTC3G CTTATTTAAT TATAAGTCTG TTTGGTCAGG TAATTCCATA 660

ATACTTGAAG CCTAACTATA GGAGTTTTGT ACTAAGGTTC TTTGCCCTTT CCTAGATTAC 720

GTCTT CACGT ATAGGACATG TAAACACAGC AACTCGAG 758

(2) INFORMATION FOR SEQ ID NO: 704:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 63 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:704:

GAATTCGGCC AAAGAGGCCT AAGATGGCCT TCCCATGTTA TGGCTACATG GCTGTGATAA 60

CAAGTAGAGT TATGTGTCTG CGC TCTAAAC TCACTGAGTC TTGCAGGATG TAAACATCCT 12 0

AGCTCAGCCT ATCCTTGACC AAAGCACANT CATGCTCCTT ACAAACTCCA ACCAGCCTGC 180

ACACTGGGAG GAGCGCGTGC TGGGCTAGAG CCACAGAATT TTGTACCGTT GGCAGCAGGG 24 0

AGGAGCCTGG CCCCTCCTTT CCTAGGTAGA ATCTGGAATT CAATCTGTGA GGTGGGAAGC 300

ATATACTAGG AGGACTTTCA CTCTGCTGAG TCCCTGTTCC CCCTCCCTTT TTTTTCCTTT 360

TTGCCCAATA AACCCCTTTA TTCTCACACT TCAAATTGTC TGTGAGACTA ATCTTTTGTG 420

G C CATGTG AC ATGGACCCTG TCTGTAGCTG AAACTAAGAA AAAGCCCCTC CCGCACAGTC 4 80

TGATGTTTCC TCAGTCAGAC ACTGCAAGCT GTGATGTTGG GGTGAGTACA GGATATTTGG 540

CAATATTTGC AGACAGTTTT GGCTGTCAGA GAGGAAGATG CTGTATG CAG ACACACTTGA 6 00

CAGCAATAAC TTAAGCCCAC CCTGAGACTG ACTCTGCATG GTGATGCACC TGAAGGCCTC 660

GAG 663

(2) INFORMATION FOR SEQ ID NO: 705 :

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 334 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 705:

GAATTCGGCC TTCATGGCCT AG AG CGATGT CAAGTG AT CT GCCCGCCTCA GCTCCCCAAA 60

325

WO 98/45437 PCT/US98/06956

GTGGTGGAAT TACAGGCGTA AGCCACTGCG CCTGGCCCCA AGTGTCCATT TTTTAATTTA 120

GTAATTCTAA CCTAGGTATT TTTCCTGCAG TACAAAATGA GGATAAAGCT TTACATGAAA 180

ACATGTTGTT CCTATTATGT TTATTGCAGC AAAAACACAA CCTAAAAACC CAATCTGAGC 24 0

AGGTTTTAAC TAAATACTAA TAATTCTGAC ACTAGAACGT TATGTAGCTA ACAAAAATAT 3 00

GTCGTAAAAA TAATCATGTA GAAACTGGCT CGAG 3 34

(2} INFORMATION FOR SEQ ID NO: 706:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 369 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:706:

GAATTCGGCC TTCATGGCCT ACCGAGCTTC AGAGCATCAG CAGTGTTCCT CCTTCACTGT 60

GACGCTTGTC CTCACTTCCC AGGTGAGGAG TCTAAGAAAA CAGCCTTTCC ATCAGCCCCT 120

GTCGTGACAG ACCCTCCAGT GGGATGGTAG TGGCTGCCTC ACCCATTTAC AGGGCAACCC 18 0

AGTTTTGCTC CTTCTGCCTT GAAATTTGTT CCTCCCAGAA ACTGTCCCTC ACAAGG CATG 24 0

AACAATCAAT AGAAGATATA CGTGGTCTTC CCAGCACTAC AGCTGCAGAA TGAGCTGTGG 3 00

AGTGCCCCGT CCGGAGTCCT GAACAGCTTC AAACTTTTCC CCTTTAGAAA TGCCTAACAC 3 60

GCCCTCGAG 3 69

(2> INFORMATION FOR SEQ ID NO: 70 7:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 365 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 707:

GAATTCGGCC TTCATGGCCT AGG CAT CCTT GGTGCGGCAT CCTTGGTGCA TTATATCAGG 60

AGGCAAATGA TGTGGGTTTG TCCCATTGTT TGTAATGGTA ACATTGGTTG CTTGGTTAAG 120

GTGAAGGGTG CCAAGCTTCT CCACTGTAAA GTTCCTATTT TTTTCTCTGT AATTAATAAG 180

TAATTTGTAT GATACTTTGA GATAACAAAG TAGACTGTTC ATCAAACTTT CATCAATGAA 240

TTTAACATCC AAAGACGCCT CAAGAATGAT CAT C AAAAG C AG CCTACTAA TGACTGTCAT 300

TTACCATTTA ATACATTTCA AACAGTGCAC GTGCTCTGTG ACATATTCTG GGAAGGAATC 360

TCGAG 3 65

(2) INFORMATION FOR SEQ ID NO: 70 8:

(i) SEQUENCE CHARACTERISTICS ;

(A) LENGTH: 436 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 708:

GAATTCGGCC TTCATGGCCT ACACAAAGCT TCTGGAGGAC AAACGGGAGC AGTTGAAGAA 60

326

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GAGCAAAGAG CATGAGAAGC TGATGGAGGG AGAACTTGAA GCTTTGCGGC AGGAATTTAA 120

AAAGAAAGAC AAGACGTTGA AAGAGAATTC CAGAAAGTTG GAGGAAGAAA ATGAGAATCT 180

CCGAGCAGAG CTACAGTGTT G TT CTACACA ACTGGAATCC TCTCTCAACA AATACAACAC 240

CAGCCAGCAA GTCATCCAAG ACTTGAATAA AGAG AT AG C C CTTCAGAAGG AGTCCTTAAT 300

GAGCCTGCAG GCCCAGCTGG ACAAAGCTCT GCAGAAGGAG AAG C ACT ATC TCCAGACTAC 36 0

CAT CAC C AAA GAAGCCTATG ATGCATTATC CCGGAAGTCA GCCGCCTGCC AGGATGACCT 420

G AC AC AAG C C CTCGAG 436

(2) INFORMATION FOR SEQ ID NO; 709:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 83 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 709:

GCTGCTCTAT ATCTTAGAGA AAATAAAAGA ACCACATGTT GCTTCCCTGC CTGCAAGCTC 60

TTCTGAATTC ATCACCATTC ATGTTCCTTC CTTCAGGGGA AATGAAGGCA GATTGTTCTG 12 0

TTGGTGCTCA CAGATCTCTT TCTGTTCTGA TACCCTCCTC TTCCTCTCCT GCTTCTTTCC 180

CTTCATCATG TGCT CCTATA CAAGTCTCTC CCAACTTTAA AACAAAAACA AACCCTTCCC 240

TAAATCTTGT GTTTGTTCCA G CCATTAG AC TGTATCGTCC TTGCCATCCA CGTTATTGGA 3 00

AGAAGG CCAG CTCACCTCTA CTCCCTTTCT GCCCTTTCCC TCTTAATCTG CTGTCCTCTG 360

ATTTCTGCCC CCACAAACTC GAG 383

(2) INFORMATION FOR SEQ ID NO: 710:

(i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 4 96 base pairs

(B) TYPE: nucleic acid

(C> STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 710:

GAATTCGGCC TTCATGGCCT AGGGGCCTGA AGATCTTCGG GTATTTGGCT CCCAGAATCT 6 0

GACCACAGTG AAGCTAAAAG GGGTGGGTGA CAGCTTCAAG AAGTATCCTG ACTACGAGTC 12 0

CAAGGG CATC AAGGCTCACT TCAACCTGGA TGAGAGTGGC GTGCTCAGTC TAGACAGGGT 180

GGAGTCTGTA TTTGAGACAC TGGTAGAGGA CAGCGCAGAA GAGGAATCTA CTCTCACCAA 24 0

ACTTGG CAAC ACCATTTCCA GCCTGTTTGG AGGCGGTACC ACACCAGATG CCAAGGAGAA 300

TGGTACTGAT ACTGTCCAGG AGGAAGAGGA GAGCCCTGCA GAGGGGAGCA AGGACGAGCC 36 0

TGGGGAG CAG GTGGAGCTCA AGGAGGAAGC TGAGGCCCCA GTGGAGGATG GCTCTCAGCC 420

CCCACCCCCf GAACCTAAGG GAGATGCAAC CCCTGAGGGA GAAAAGGCCA CAGAAAAAGA 480

AAATGGGGAA CTCGAG 4 96

(2) INFORMATION FOR SEQ ID NO:711:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 75 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

327

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 711:

GAATTCGGCC TTCATGGCCT AGTATGGAAG GTGGAACTAA AACTGAAATG ATCAGTTCAC 6 0

ATATTTGTAA ACTGCGTATT TTATATCAGT CGCTGGATTA GGCCCCTAGA GACAGTGGTG 12 0

GCTAAGTGAT AAAGTCTTTG CGCTTGTGGC ATTTTATAGT GTAGTGGGAA GACAGAAAGC 18 0

AAACAAGTAG AGAATCATAT ATGTAATGTG ACCTCAGGTC CAGCTAAGCG CCAGACAGAA 24 0

GAAAAAAGTA AGGTGAAGGT AGAGGGGTTG GAGCAGGAGG AAGGTGTTAT TTTAGGTAAA 3 00

GTGGCCAGGG AAGGCCTTTT GAAGAATTGA TAT CG ATT C C AAAATGATGA GAAGGTGCAA 3 60

TTGTGCCACC ATGGAGGAGA AGAGCTTTCT AGGCAGAGGG CAGGTGCAAA GATGGTAGGA 42 0

ACAAACACGG CTTGTTGAAA GAACAGCAAT GTTTGAGGAA TGAGCCAGAC TCGAG 47 5

(2) INFORMATION FOR SEQ ID NO: 712:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 60 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 712:

GAATTCGGCC TTCATGGCCT AATTTTG CAT AAAACCTCAT CAATCTCTGC CAATCACTGA 6D

GCCCAAAACC ATTTTCACTT TGTTTTAGGT ATTTATAATA ACAGCACTCC CACTTCTCAT 120

GATCAATTTC CAT CTTCAGC GGTTCAGGCT GCTTTAATAA AGTT CCATAA CCTGAGTGGC 180

TTTTAAATAA CGGAATGCAC ATCTCACAGT TCTGGAGGCT GGAAGTCCAA CAGCAGAGTG 24 0

CCAGCATAAT TGGGTTCTGG TGAGAGAGCT CTCTTGGGTT TCAGACTGCT GCCTTCTCAA 30 0

TGCAGCTTCA CATGGTGGAC AGAAAGAGCT CTCAAGAGTC ATTTTTAAGG GCACCAATCT 360

AATTTATGAA GCCTCCACCA TAATAAGCTA ATTACTTCCC AAAGTGCTGA G ATTACAG CT 420

GTCAGCCACC GTACCTGCCT GGGAATTTTT TTAAAGCTCA AATTGGATAA GAGGGTTATA 4 80

GGAATATATT CATCTATCAT ATAGAAAAGA ATATGTGCTC AGTCC CAGGA AATAGAAAAT 54 0

ATATTACCTT ATTTATACTG TTTTAATTAA TGCTTTTTAA AATCTGATTA ACTCTGGGAG 600

AGCTCGAG 60 8

(2) INFORMATION FOR SEQ ID NO: 713:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 531 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:713:

GAATTCGGCC TTCTTGGCCT AGTGCACTCC TGTAATCCCA GCTACTCGGG AGGCTGAGGC 6 0

AGGAGAATCA CTTGAACCCA GGAGGTGGAG GTTG CAGTGA CCCAAGATCA TGCCACTGCA 120

CTCCAGCCTG GGTGACAGAG CGAGAACGTC TTTAAAAAAA TTAAAAAAAA AAAAAAAAGA 180

TTG CACAAAT C AG AC AG TGA CCCAGAGCTC AG CC TTGAGG AAAGTCAGTG TTGGGGAGGG 24 0

GAGGGCAAAG AAG CAAGTAA AGGTTTAGCA GACATGGCAC CTCAGTCTGG ACTTGAAGGA 300

GGGCTAGGCA CAAAGGAAGG GGAACATGTC AGATGAGAAA CACGTGAAGG TTCAGCCAGA 36 0

TGAGCAAGGA AGGTTGGTTA GAAAGAGGAG CTGCTGGTGT GGCTCCTGTG AACACAGGTA 4 20

GATAGGGCAC GATAGAGTCA GG CAGTTAG A AG CCAAG CTG AGGAATCGAC ACTTGATTCC 4 80

ATAGGTAAGT AGGGGAACTT GAGGATGTTT AATCAGAAAT GAGATCTCGA G 531

(2) INFORMATION FOR SEQ ID NO: 7 14:

328

WO 98/45437 PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 99 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:714:

GAATTCGGCC TTCATGGCCT AATTTATCCC ATCCTTATCC CATCCTTATA AGGAATAATG 60

TATTGAATAA AGATTGTATC AGTATTTGTA ATTCAATAAA CCAGAACTTG TGGAAATAAA 120

TATGTAGGAG ACATAAATAT GGTGTCCTCA AATTGAATTA TGTGGGAAAA AAGTGGGGTG 180

GAGTTAAAGT CCAAG CCAAT AAAGTTG TAA CATTAAAGAA AGACAGGTAT GGGATGCAAG 24 0

GTGCAAAGAA AAGGTCATCA TATCTCATAC TGGGGTGAGA TAGAAGACTT CCTGAAGTAG 30 0

GCGATGCCTA TATTGAATCT ATAAGGACAA ACTGGCATCA ATATGTCAGG GAAGACAGGT 36 0

TGAAGGTGGT CCTGCCAGAG AAAGGAGCAA GGATAAAGGC AAGGAAGCAT GTAACGTAAT 420

TGTTTGTGGA GAAACCT CAA ATCGGCTGAG GAAAAACGAC TCAGGTATGT AGTAGGGCAC 4 80

AGTATAAG T A GGTCTCGAG 4 99

(2) INFORMATION FOR SEQ ID NO: 715:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 0 base pairs

(B) TYPE: nucleic acid
{C> STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 715:

GAATTCGGCT TCATGGCCTA GAGATTTAAT GTTCCCTTAC CTTGCTGGAG GAACAT CAAT 60

GTTGGAGGAA ACAACTTTTC TTTTTTGCTC AAGGAGACAG ATGGAGCGAG TGTTTTCTTT 120

TTCATGGTCA AGGAT CCGGC TGG CTTTTTT GGTGTCTGCT GTTTTCACAT CTTCCTCCAT 180

GGCCAAGGAA AACACGTGTT GATGAGACAT TTTTTTACCA CAG TCACGTT TTAAGTCCTC 240

TGACTGAAAT GTGAAGGTCA TTTCCCGCTT AATGCTCCCC ACCTGTGAAA TGAAACACAG 3 00

AAATTCTTAC TCACATAAAA CATCACCTTT GTACGACTAC TGCAGATGGC GGTGAGGAGA 3 60

GATTACAGAC ACTGTCCTTC CTGTTCATCT GAAAGATTGT ATAATTTTAA TAAGAAAAAT 420

GCAACTCGAG 4 30

(2) INFORMATION FOR SEQ ID NO: 716:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 71 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 716:

GAATTCGGCC TTCATGGCCT AGACCTTCTG GGTGAACGAG GGCAAGCACG CCAAGTTCCG 60

CTGCTACGTG ATGGGCAAGC CCGAGCCCGA GATCGAATGG CACTGGGAGG GCCGCCCGCT 120

GCTCCCGGAC CGCCGCCGCC TCATGTACCG CGACCGCGAC GGCGGCTTCG TGCTCAAGGT 180

GCTCTACTGC CAGGCCAAGG ATCGTGGGCT CTACGTCTGC GCCGCGCGCA ACTCGGCGGG 240

CCAGACGCTC AGTGCCGTGC AGCTGCACGT GAAAGAGCCC CGCCTCCGGT TCACACGGCC 3 00

CCTGCAGGAC GTGGAGGGCC GTGAGCACGG GATTGCCGTG CTGGAATGTA AAGTACCCAA 360

329

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CTCCCGCATC CCCACGGCCT GGTTCCGTGA GGACCAGCGG CTGCTGCCCT GCCGCAAGTA 4 20

CGAGCAGATC GAAGAGGGCA CTGTCCGGCG CCTCATCATC ACAGGCTCGA G 4 71

(2) INFORMATION FOR SEQ ID NO; 717:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 717:

GAATTCGGCC TTCATGGCCT AGCCACTCTT AGCAACACAG ATTTTCTTCC AAATTATGCC 60

TTGAAGCTGC TCCCGGAGCC ACCCGCTCAT CAGCACCCTG CTCCTGTGGT CCTTCTCGTG 120

AAAGGCAGAG GGGAGATGCC TGTTGCCCGC AGTCTTCTCT GCAGCTGCCG TGGGAACAGG 180

CACCTTCCCG GCTGCTGGGG ACACAAGGAG GGGGAGTCAC CGTGGCTTGC TCACTTTCCA 24 0

GATCAGCCAA CTGCAGAACA TTTGTTGTTG TTTAG AT CCC ACGTCTGACG GTTTAGAACA 300

GCTTTTATAA CATGGTTAAA CATGTTTACA AAGCAAGGGA GACATCTCTT ACCTTGACAA 360

CACGAGGCTC CCACAGACCG CCTTCCCCCA GCTCGAG 397

(2) INFORMATION FOR SEQ ID NO: 718:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 53 9 base pairs

{B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE-: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 718:

GAATTCGGCC TTCATGGCCT AGAAGGAAAG AAATTTTATG TGAGAGAGCA TCTTGTATGG 6 0

CAAATTCTTG TCCTAAAGTA GAATGACTAG GAAAGAGCAA' AATATAGGAC AAGTCAGAAA 120

GTCATAAGAT GGGAAAGAAA AACTTACAAC TGCTAGATCT TCTCCTGTCT AGAAGTGTTG ISO

TGTGTGTGAT GCTTATATGA AGGTACTCTA ATTAATTGGA TTAAGAGAAA ATGAAACCCC 24 0

ATCTCTACTA AAAATACAGA ATTAGCCGGG TGTAGTGACA CATGCCTGTA GTCGCAGCTA 3 00

CTCAGCAGGC TGAGACAGGA AGATAACTTT AAC CCAGGAG TTGGAGGCTG CAGTGAGCCA 3 60

AG ATCGCGC C ACTGCACTCT AGCCTGGGAG AGACAGAGCG AGACTCCGTC TCAAAAATGA 42 0

AAAAGTAGAG CCTGGTAGAG TGAAGCCACT TGCAGGAGTC GTTTAGTTAG GGCTGTGTTG 4 80

CCTTACAGTG CTGGTGTCCT CACAGATGAT AATAGTAATA AAAAACACCA CAACTCGAG 53 9

(2) INFORMATION FOR SEQ ID NO: 719:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 87 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 71 9:

GAATTCGGCC TTCATGGCCT AGGCAGTGGA TAATTGTCCT CTGGAGGAAC CATCTGTGAC 6 0

ACATTCTACA TGGTTCCTTA GAGGGTCCCC AAGTGGGATT GAGTCCCTCT TGTTCCTAGC 120

330

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AGTAAGCAGT TCTGTTATAC ACTCTTTATA TGCTTTTCCT CCTTTCCTCT CTCAGTCTCT
CTGATCCTTC CACCTGTGCT CTGGGTTCAC CTCTCAAGTA AACCACCTGC ACACAAGTCC
CTGTCTCAGG CTCCATTTGG GGAAACCAAA CTAAGACACC AC CTCAAAAC ACAGAATTTC
ACGAGGCTCC AAATGCCTCA GAAAAGTAAT GTAAATATAA AATGACCAAT TTTTTGAAGT
ATATTAATCC TAGT TATTT A ACTCGAG

180
240
300
360
387

(2) INFORMATION FOR SEQ ID NO: 72 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 720:

CCCGTGTATA GTTTGCAAAT ATTTTCTCCT CTTCTGTAGG CTGTTTACTC TTGTTGATAG 6 0

TTTCTTTTGC CATGCACAAG CTTTTTGGTT TAATTAGATC CCATTTGTCA ATTTTTGCTT 120

TTGTTGCAAT TGTTTTTGGC GTCTTCATCA CGATATCTTT GCCAGTTCCT ATGTTCAAAA 180

TGGTATTACC TAGGTTGCCT TCCAGAGTTT TTATAGTTTT GGGTTTTTAT TT ACTCGAG 23 9

(2) INFORMATION FOR SEQ ID NO: 721:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 323 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 721:

CTCGAGCACT ACCCTAGACG GTCTCATCAC TATACTGGCT CCTCCTTACC CCCGTAAATC 60

TCCCAGGTAC ACTTCCTGAT CACCCTCCGG ATACCTCATC CCTATCTATT CCTTTTATAA 120

ATAATTCCCT GCTCCTCCTT CTCACCCACA ATCCACTCGC AGTTCAAGGC CTCACTGCCA 18 0

TCGACTCCAC TGTCTGTGAG TGCTTCCCAA TATG CCCCAG GACCCCTCCT GGTGTCACGC 240

TCTGTATCCT GACACCCCTT GTAGACGAGT CCCGAAATTC CCGCCCCGTC CCTGGAGCTC 3 00

CCTAGGCCAT GAAGGCCGAA TTC 3 23

(2) INFORMATION FOR SEQ ID NO:722:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 275 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 722:

GAATTCGGCC TTCATGGCCT AGGCCTGTGG AGCCCCAGCT CTGGGTCCCT AGCCCGGGTC 60

CAGGCAGCCA GGCTCCCTCC TGAGCTGAGA AACGGAACCT CGCGAACCAC TGGTGGCACA 120

TCCTTCTCCT CCCCCGCCCC TGATCACCCG CCCCCGGATC AGAAATATAT CTATATTCTC 180

GACTAAAGTC TCATCAGGAA ATATTTCCTG TCTTTTATTT TAAGCATCAA ATTGTTTTAG 240

TTGATTTAAA AAGGAAAAAA TACAGACGAC TCGAG 275

331

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(2) INFORMATION FOR SEQ ID NO: 72 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 317 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 723:

GAATTCGGCC TTCATGGCCT AAGAAGCAAC AATCATATTA GCTGGGGGAG GAGGATAGTT 60

TGGTATTTTT GTAGTTTGCA CAGTGACCTT TTTAAAAATC TGGTTAGGCA AAAATAGTGT 120

GATCTTGTTT GTTGTCTCAC TTCATTATGA TCACAGAATG ACCTGGTATG ATGTTAGTGT 1B0

TTTATGAGAG TGTTATGTTT TAACAGGGGA ACACCGCAGT CAATTCCTAA CAACACTAAA 24 0

GTGTCAGTTC TGTTCGTGAC AC CAAGGG CT GTTTTTCTTT TTCTCATATA ATGTTGAGGC 3 00

AACCAGGAAG ACTCGAG 317

(2) INFORMATION FOR SEQ ID NO: 724:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 267 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 724:

GGCCTCAGCA GGTGTGAAGC GTGTGCTTTA GTTTCGTGGG AGGCCTGGCA TCCCCGAGAG 60

GGAGGGGAAA GGTAACCACT CCTTTGTGGA GGTCGCCAGG GTCATTGTCG TGGATTTGCA 120

CAGTCGGCTG GGCGGTGCAA TGG CGGAAAG AAAAGGAACA GCCAAAGTGG ACTTTTTGAA 180

GAAGATTGAG AAAGAAATCC AACAGAAATG GGATACTGAG AGAGTGTTTG AGGTCAATGC 24 0

ATCTAATTTA GAGAAAGCAG ACTCGAG 26 7

(2) INFORMATION FOR SEQ ID NO: 725:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 54 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi)' SEQUENCE DESCRIPTION: SEQ ID NO: 725:

GAATTCGGCC TTCATGGCCT AAGTCAGTGG TAAGCCGCAG CAGTTTCCTG CCACTCGTAA 60

TATGGCAATT AAAAATTTTA AATTTGTGGC TGCTTGGGGT CTGGGAGGTG ACCTGCTCCT 12 0

CAG CAAATTT TGAC TGATAA ATTAATGCCT GGGTCTTCAG CCTGGTTCTT TGCTGGCCAG 180

TGTGACAACA GTCTGTCACG TCTCTGGGGG CACATTATAA TTAACAGATG TAATCTTTCT 240

CCGGTTCAGG GTCATCTGTG AATCAGGGGT ACTGCCCCAG TAGAACTAGG AACATCCAGC 3 00

AAAAGACTGT TTTCAAAATA TACAATTAAG TGAAAAAAGC ATGAAGAACT CGAG 354

(2) INFORMATION FOR SEQ ID NO: 726:

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 154 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 726:

GAATTCGGCC AAAGAGGCCT AGAGGTTGAC CTGAAAAACA ATGAAACACA TGAACACACT 60
TCCGATTTTC TCCTCGCTGA TTAGCTTCCT GCCTGCTGTC AGTGCTGGAC GAAGTGCTAT 120
AACTACTTTA TGTAACATTA C AG AACAG CT CGAG 154

(2) INFORMATION FOR SEQ ID NO: 72 7:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 33 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 72 7:

GAATTCGGCC TTCATGGCCT AGTGGGAAGA TGTGGATGAT GAGAAGGGAG ATAG CAATG A 60

TGACTATGAC TCTGCAGGCC TATTGTCAGA TGAAGACTGT ATGTCTGTGC CCGGAAAAAC 120

TCACAGAG CT ATAGCAGATC ACTTGTTCTG GAGTGAGGAA ACAAAGAGTC GCTTCACGGA 180

GTATTCGATG ACTTCCTCAG TCATGAGGAG AAATGAACAG CTGACCCTAC ATGATGAGAG 24 0

GTTTGAGAAG TTTTATGAGC AATATGATGA TGATGAAATT GGAGCTCTGG ATAATG CAG A 3 00

ATTGGAAGGT TCTAT TCAAG TAGACAGCAC GACTCGAG 33 8

(2) INFORMATION FOR SEQ ID NO: 728:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 3 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:728:

GAATTCGGCC TTCATGGCCT AATTGAATTC TAGAACTCTC CCAGAGAAAC CAGGCAGATA 60

CTGCTCCACA CCGGTGAGCT GCTTCTCACC TGGGTAGTCT AGGGTGGTTT GCTCCAGAAT 12 0

TGTATTTCTG CTTTTTCTTT TTTTAACTTG GCAGTGGTTA ACCATTCCCT GGAGCAGCAC 180

CAGGTAAGTC AGCTTGTATC AGAGTCATCT GCTTTACCTG ACATGAGCAC ACGTTGTCAT 24 0

ATATTTGCAC ATGCAGATAT CATATGTTAA ACAATATCAC ATTGTTGAAG AAAATTACAC 3 00

TGGAAAGCGT AAAATATAGT TTGGATGCCA TATTGAGTGT AACTTAATCC ACCCGATTCA 36 0

GAACTTTTGT AGAGTGCCTC GGAGTTCCTA TTTGGAAATA TCAGTTAGCA GTTTTAGTCA 4 20

GTAGAGACTC GAG 433

(2) INFORMATION FOR SEQ ID NO: 729:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 315 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

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(D) TOPOLOGY: linear
(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 729:

GAATTCGG CC
GAGATGCTCC
TGGCCCATGT
TCGTGTTGCC
AACTGCTGTG
GCGGTGGGAC

TTCATGGCCT
GCTACAAAGA
ACCTGATGCG
TGTGTCCTGC
GCTGTAATGC
TCGAG

AACAAG AAA C
GGTCTGCTAC
GAAGCCCGCC
GAGGCCGCGG
CATTGCCATC

AC CAAGTACC
TACATGCTCT
TGCGGCCTCT
TTCGCCCCTG
CGGCGCCACT

TCGACCTCAA
TTGCCCTGGC
GCCAACTGGC
GAGTCACCAT
TCCTGGACGA

GAATTCACAA
TGCCTACGGG
TCGGTCCTGC
CGAGGAAGAC
GAACATGACT

(2) INFORMATION FOR SEQ ID NO: 73 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 156 base pairs

(B) TYPE: nucleic acid

(C) STRAND EDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 730:

60
120
180
240
300
315

GAGTTGTCTC TCTGAATTAA CTTTCTCACC AATAGCTCCT CTTTAAGATC AATAACTCTT
ATGTTTGCAC TTTTTAGGCT ATTTTCTAGA TCTTGTATGT GTGTCTTATT ATTTTTTATT
CTTTTTGTCT CCTCTGTGAA TTTTCAAATA GTCGAG

(2) INFORMATION FOR SEQ ID NO: 731:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 223 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 731:

60
120
156

GAATTCGGCC TTCATGGCCT ACTTGAACCT AGATCTCACC CCCAGGATGT TGCGGAGGCT 6 0

GCTGGAGCGG CCTTGCACGC TGGCCCTGCT TGTGGGCTCC CAGCTGGCTG T CATGATGT A 12 0

CCTGTCACTG GGGGGCTTCC GAAGTCTCAG TGCCCTATTT GGCCGAGATC AGGGACCGAC 18 0

ATTTGACTAT TCTCACCCTC GTGATGTCTA CAGTAACCTC GAG . 223

(2) INFORMATION FOR SEQ ID NO: 732:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 09 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 732:

334

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GAATTCGGCC TTCATGGCCT AAATTATTGC AAAGTG TATA TTGGTTAAAA AAAAAAAGGA 60

GGAAGAGGCA GTTTTTCATG ACGGTTAAAA G TGCAGG ATT TGGAGTCCCA TGGTCCTGGG 120

TGTGAATCCT GGCTGTGGCA CTAACTATCT GTGTGACTGG CTGTGAACCT CTCGTGCCTC 180

ACTTTCTTCA TCTGCAAAAT GGGTAGTTGT ATAGCAAATG CACATAGAGA ACACTTAACA 24 0

CTTTGGCACA TTGGAAGCAC TCAGTAAATG TTAATTGTTA TTATTGTTGC TCTAAAGAGA 3 00

ATCCTCGAG 30 9

(2) INFORMATION FOR SEQ ID NO: 73 3:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 275 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS ; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 73 3:

GAATTCGGCC TTCATGGCCT AGATTAATTC TAGACCTGCC TCAGCTCCAC TCCTTATGGT 6 0

TTGCCACCAT AACCTACAAC ATTTGTCCGT CCACCCCACG TGTCTTCTTC CTTTGTGGCA 120

GGAACTCTTA TCTCTGCCTA CCAACCAATT GGTCAGGAGC ATGCACCCTA GTGTCTCAAT 180

CTCCAGACAT TAACATCCTG CCAAACAACC AGACCATCCA GGTTCCTTTA GTGACCCCTA 240

TCTCATCCTC TTCCACATGC AGTAGG CAGG TCTAG 275

(2) INFORMATION FOR SEQ ID NO: 734:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:734 :

GCAGATCAGA GGCACGTTTC CCACAACTGC GAAGAGGCGC TGAGGCAATT CTGCAAGAAG 60

ATTTTGGGGT TTTGGAAAAG AAGCTATGGA AAACGGAGGG GCAGGCACTC TGCAGATAAG 120

GCAAGTCCTG CTTTTCTTTG TTTTGCTGGG AATGTCTCAG GCGGGCTCTG AAACTGGGAA 180

CTTTTTGGTG ATGGAGGAAT TGCAGAGCGG GAGCTTTGTA GGAAATTTGG CAAAGACCCT 24 0

GGGACTCGAG 250

(2) INFORMATION FOR SEQ ID NO: 73 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 324 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 73 5:

GAATTCGGCC TTCATGGCCT ACACAGACTG GGCAATTTAT AATGAACAGA AGTTTATTTG 60

GCTCTTGGGT CCAGAGGCTA GGAAGTCCAA GAG CATGGTG TCAAG CAT CA GGTGAGGATC 120

ATCACCCCGT GG TAG AAGAT GGAAGGCAGA AGTGAGCGTG TGAGACAGAG AGGGAGAATT 180

GGACTCAACT CATCCTTTTA ATCAGGAACC CACTCTGTCA GTAACGAACC CATCCCCACA 24 0

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ATAATGGCAT TAATCCATTC ATGAGGCCCC TACCTCTTTT TCTCCCCCCG CCCCCCGAGA 3 00

TGGAGTTTTG CTCTTGAGCT CGAG 3 24

(2) INFORMATION FOR SEQ ID NO: 736:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 2 59 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 73 6:

GAATTCGGCC TTCATGGCCT AAACACATAC CAGATTCTTA GATTCATTTG GTGAAGGAAG 60

CCTCTGAATT AAAACTTTTA AATATTTCTG ATTTGCAACC AGACGAAAAA GAAGAAAATT 120

GACAACTTTT TTGATGCAAC TTTGTGAAAT CATGGTGTTC CTGGTTTTTC TGGTCTGGTT 180

TTTGTTGTTG TTTTGTTTTG TTTTGCCACA GTTTAGTTCC TCACCTGATC TTTCCTTGTA 24 0

TCCACTTCAG AGTCTCGAG 259

(2) INFORMATION FOR SEQ ID NO: 737:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 09 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 73 7:

CTCGAGGCGG TGCCAGACAC GGGTCTCCTC CGACTGGGCG GTGCGTGGGA TGCCGCCAGC 60

GTCCAGGTAC TGCGTGATGC GGATGTAGGC GATGCAGGCT GACTCGTCGC CCATCAGGTG 120

GATGTGGGGA TTCAGGATGG TGGTGTGCAC GGGCTTGCTG TTCCGGGACC ACAGGTTTTC 18 0

AAAATAGAAT CGATGGAAGT CCAGGCCCTC AACCAGGTTC CCCAGGGCCT CAGGTTCGAA 24 0

GGCTGTCATG CCAGGGTCGC ACATCTTCGT GTAGGACTCA AAATCTCCAT TGCTTATGGC 3 00

TTCAATCAGC TGCTCTGTCA CTTTTATAAT TTCCTGTTTC CGCACTTTGG TGTCTTCATC 3 60

CTCGATGGTG GTGTTGGTGC TCTCTGAGTA GGCCATGAAG GCCGAATTC 40 9

(2) INFORMATION FOR SEQ ID NO:738:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 66 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:738:

GAATTCGGCC TTCATGGCCT ACTTTCCCCT CCTTCCTTCC TTCCTTCCTC CCTCCCTCCT 60

CTCTCCTCTC TTTCTTCCTT CCTTGCCTCC TTCCATCCTT CCCTCCCTCT CTCTCTTTCT 120

TTCTTTCTTT CTCTCTCTCT CTCTTTCTTT CTTTCTCTCT CTCTGTCTTT CTTTCTCTCT 180

TTCTTTCTTT CCATCTTCTT TTCTTTCTAT CTTTCTTACT TTTGATGTAG CTGTCACGAC 240

CTAATGAAAA TACTGGCATG AG TGATG CCA CCTTTAGATT CTCCACCTTC CTGTTCCTGT . 3 00

CCTATTCACC AACATGAATT GGTTTGTGGC TGTAAGTACT TGGTGGGTTA TTG CTCATAG 3 60

336

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ATTCAGTTGC ATTTTTGCTG AGATAGTGCT GTTACCAAAA GCAGGGGTGC TGCTTGAAGA 4 20

AGTAAACCTA ACTCTGAAAA ATAGAGACTC TCCAGAAACA CTCGAG 4 66

(2) INFORMATION FOR SEQ ID NO:739:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 739:

GAATTCGGCC TTCATGGCCT ACATTCTGCA AACTATTTTG TTATTAGCTT TTTCACTTAA 60

AAATAGCCCT GCTTGCAAGC AGGCTCTGTG GTG CAATGGA TAGCG CAT TG GACTTCTAGC 120

CTAAATCAAG AGATTCAAAA ATAGCCCTGC TAAATATTTG CAATCTTTCC TACGCTCCTT 180

TTTCCCCCAA AGTGACTTTG GATATCCAGA GTTAC CAAAT CTAGTATTTG AAGTCCTTAG 240

GTTTGAGGGT TGAAAGTGAA AGGCAAGCTG TTTTAATGAA AATTCCTAAC TGAAGAGAGC 3 00

GGAGACTTAA G ATG CTTAAA TTTTGGTCAC ACCTGAGCGG TATTTGTTTG CATGGCAGGA 3 60

G CTCGAG 3 67

(2) INFORMATION FOR SEQ ID NO: 740:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 740:

G TGATGG ACA AAGACAGGGA AGGCCTCATC AGCAGGGATG AGATCACAGC CTACTT CATG 60

AG AGC CAGCT CAATCTATTC CAAGCTGGGC CTGGGCTTTC CTCACAACTT CCAAGAGACC 120

ACCTACCTGA AGCCCACTTT TTGTGACAAC TGTGCTGGAT TTCTCTGGGG AGTG AT CAAA 180

CAAGGAT AT C GATGTAAAGA CTGCGGGATG AACTGTCACA AACAATG CAA AGATCTGGTT 240

GTGTTTGAGT GTAAGAAGCT CGAG 264

(2) INFORMATION FOR SEQ ID NO: 741:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 318 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 741:

GAATTCGGCC TCATGGCCTA CACGACCAGC ACCGCCACTG CCACCTCACA GCCTTTCCTC 60

TTCGGGGCGC CCCAGGCCTC TGCTGCCAGC TTCACCCCGG CCATGGGCTC CATATTCCAG 120

TTTGGCAAAC CTCCTGCCTT GCCCACAACC ACCACAGTCA CCACCTTCAG CCAGTCCCTG 180

CCCACTGCCG TGCCAACGGC CACCAGCAGC AGCGCTGCCG ACTTTAGTGG TTTTGGCAGC 240

ACCCTCGCCA CCTCCGCCCC GGCCACCAGC AGCCAGCCCA TTCTGACGTT CAGTAACACG 3 00

AGCACCCCCG GCCTCGAG 318

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(2) INFORMATION FOR SEQ ID NO: 742:

(i) SEQUENCE ■ CHARACTERISTICS:

(A) LENGTH: 256 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 742:

GAATTCGGCC TTCATGG CCT AAGAAATGAA AAAGATTATT GAAACTATGC CAATGACTGA 6 0

GAAAGTTGAA GAATTGCTGC GTGTCATAGG TCCATTTTAT GAAATTGTCG AGGACAAAAA 12 0

G AG TGGCAGG AGTTCTGATA TAACCTCAGT CCGACTGGAG AAAATCTCTA AATG TTTAGA 18 0

AGCTGAAAGC AGTGACAGTG GAGCCGAGTC TGAGGAAGAA GAGGCCCAAG AAGAAGTGAA 24 0

AGGAGCAGCC CTCGAG 256

(2) INFORMATION FOR SEQ ID NO:743:.

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 580 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74 3:

GAATTCGGCC TTCATGGCCT ATGTTTTTAT AG CACCGATG GTACTGTTTT ATTTATTGCC 60

AATAGACCAC AACATTCACA TCTGTTTTTC CTCAAGGGAA CCGTATTTGC TTTTGGTTGA 12 0

AGGATTTATC TATTTGATAC TATCCAGAAT ATTGTGAAGC TATAATTTCC TGGGTTATAT 180

TTTAGATGGG TTGTCTGCAT GGTGGTAAAA TAAG CTTTTT CCTCTCGCCT ACGTCCTTTG 24 0

GAAGATCTCC TGATCATACA TAACTAGGTA GGGCTTATTC TTGCTGCCGG AGCTTGGCAC 300

CCAGCTCTAG ACTGTTTCTT TGAGCATTAC TGCAGATTGG AGACGTGTGT GAG AGGAG CA 360

GCGCTCAGAA ATAGGGCTTG AGGCTCAAGC AGAAACTGAA GCTCTCATTC AAATGAAGAT 4 20

GCTCTCTCTA CCGCACGATC GGCAGTGAGA AAAGGAGGAT GAAAATCCTT CTCATCACAA 480

AGAG CTTGAA GGAACCCACG TCCCCAGATT AGCAACCCTA GAGTTCATCT GCTCAGGCCG 54 0

GGAAATGTGT AAGCTTCCTT GATCAACTCC AGGCCTCGAG 580

(2) INFORMATION FOR SEQ ID NO: 744:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 74 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 744:

GAATTCGGCC TTCATGGCCT ACCCAGAGAC TCGCGGACGC TCACGATAAC CAAGGACGAC 60

CGCGAACCAA GGGCAAAATA ACATGGCAGC CAGACGAATT ACACAGGAGA CTTTTGATGC 120

TGTATTACAA GAAAAAGCCA AACGATATCA CATGGATGCC AGTGGTGAGG CTGTAAG CGA 180

AACTCTTCAG TTTAAAG CTC AAGATCTCTT AAGGGCAGTC CCAAGATCCA GAG CAGAG AT 240

GTATGATGAC GTCCACAGCG ATGGCAGATA CTCCCTCAGT GGATCTGTAG CTCACTCTAG 300

AGATG CCGGA AGAGAAGGCC TGAGAAGTGA CGTATTTCCA GGGCCTTCCT TCAGATCAAG 360

338

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CAACCCCTCT CGAG 374
(2) INFORMATION FOR SEQ ID NO: 74 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 323 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74 5:

GAATTCGGCC AAAGAGGCCT ATTGGTTTCC CTGCTTCCAT TCTTACTCCC CTACACTCTG 60

TTCTCCAAAA AATAACCATT GTGATCCTTT AAAATCCTGA CTCTCTCCTG CTCAGAGTCA 120

TCCAGTGGCT TCCCATATCA CGTAAAATGA AACCCCAATC GCTCCTTACT CTGGCCTGCA 180

GGGGCCTGTG TGATGGGCCT TCTCCAGCTT CGTTCTTCCT TTCCTTCTGT TCTCCCCTCT 24 0

GCTTACCTAC TCCATCTCCA GGGCTTCTTT CCAGCTCAAG CCCTTTCCTG TTG AG AG CAT 3 00

TTGCTTTCCC CAGGGCACTC GAG 323

(2) INFORMATION FOR SEQ ID NO: 74 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 273 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 746:

GAGAACAGTG TTACCAAAGA AAAGGACATG TTCAATTTCA AACG AG C CCA GGAGGACATC 60

TCTAGACTTC GCAGGAAGCT GGAGACCACA AAGAAAC GAG ACAATGTACC CAAGTGTGAT 12 0

GAG AT TCTGA TGGAAGAGAT TAAGGATTAC AAGGCACGCT TGACCTGTCC ATGCTGTAAC 180

ATG CGTAAAA AGGATGCTGT TCTTACTAAG TGTTTTCATG TCTTCTGCTT TGAGTGTGTG 24 0

AAGACACGCT ATGACACCCC CCCCGCGCTC GAG 273

(2) INFORMATION FOR SEQ ID NO: 747:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 66 base pairs
(B> TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:747:

GAAGATCTTC GCTGTCCTCT CTGCCTCTAT CACACCAAAT ACAAGCG CAA CATGATTGAC 60

CACATCGTGC TG CAC CGAG A AGAGCGTGTT GTCCCCATTG AAGTTTGCCG GTCCAAACTG 120

TCCAAATACT TGCAGGGAGT AGTTTTCCGC TGTGATAAGT GTACCTTCAC CTGCTCCAGT 18 0

GATGAGAGCC TCCAGCAACA TATAGAAAAG CACAATGAAC TGAAACCTTA CAAATGCCAG 24 0

CTCTGCTACT ATGAGACCAA G CACACGG AG GAACTGGACA GCCACCTTCG GGATGAGCAT 300

AAGGTAAGCC GTAACTTTGA GCTGGTTGGA CGGGTTAACT TGGATCAGCT GGAACAGATG 360

AAGGAGAAAA TGGAGAGCTC CAGCAGCGAT GATGAGGACA AGGAAGAAGA AATGAACAGC 420

AAGG CTGAAG ACAGAGAGCT GATGAGATTT TCTGACCACG GGGCTGCTCT TAACACTGAG 4 80

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AAGCGTTTTC CATGTGAATT TTGTGGACGG GCGTTTTCAC AGGGCTCTGA GTGGGAAAGA 54 0

CATGTGCTGA GACACGGCAT GGCATTGAAT GACACCAAGC AGGTG AG CAG AGAAG AAAT C 6 00

C AC C CAAAAG AGATCATGGA GAACAGTGTT AAAATGCCCT C CAT AG AGGA AAAGGAAAGT 66 0

CTCGAG 666

(2) INFORMATION FOR SEQ ID NO: 74 8:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 79 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74 8 :

GAATTCGGCC AAAGAGGCCT AACAACCGAA TATAGTACAC GACCTTCCTG CAGCAGTTCT 60

AAGCTACTGT CAAGTATGGA AAATCCCGGC AATTCTGTAC TTGTGTTATA CTGATGTGAT 12 0

GAAATTAGAC CTAATCACAG TGGAAGCTTT TAAGCCTATA CTTTCTACCA GAAGCTTGAA 180

GGGTTTGGTT AAGAATATTC CCCAAAGCAC TGAGATACTA AAGAAATTGA TGACAACNAA 24 0

TGAGATTCAG AGTAACATTT ATACATGATC TTAAACATTG TTTTGTAGTG TATATTACTT 3 00

GTCCATTCCT TTAAGGGGAG CAGCCTGCAC TCTTTTGTAG ATTACTTTTG GGGGATATAT 3 60

TTTGAGAATG ATGAAACGG 3 79

(2) INFORMATION FOR SEQ ID NO: 74 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74 9:

GAATTCGGCC TTCATGGCCT AGG CGCAAGG CCGAGCGTTC CCAGCAGGGG GAGAAACCCT 60

TCACACCCCA GGCCCTTCAG GAACTGGGGC CTTGCCTTGC AGCCACATGG CCCCATCCCA 120

GTTGGGGAAG CCAGGTGAGC TCTGACCCTT GGGCCTGGGC CTCTGCCCCT CCCAACCCAG 180

CCCTCGTCTC CCTCGACAGC GCCCCTGCTG TCTTCCCCAC CGCAGTCACC ACCACCCGAA 24 0

ATGCCACGTG GTCACTGTGC ACTGCCCTGT TCATGTGCCT CTGCGGGGCA GGGCCTTCCT 300

GGTTTTGTTC ACTGCTGTAC CCAGATAGCC TCGAG 33 5

(2) INFORMATION FOR SEQ ID NO: 750:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 64 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 750:

GCAAAGACCC AAGAACTGAA TATGCTCCGG GAACAGACCA CTGGGCTGGC AGCTGAGTTG 60

CAGCAGCAGC AGGCTGAGTA CGAGGACCTT ATGGGACAGA AAGATGACCT CAACTCCCAG 120

CTCCAGGAGT CATTACGGGC CAATAGTCGA CTGCTGGAAC AACTTCAAGA AATAGGGCAG 180

340

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GAGAAGGAGC AGTTGACCCA GGAATTACAG GAGGCTCGGA AGAGTGCGGA GAAGCGGAAG 24 0

GCCATGCTGG ATGAGCTAGC AATGG AAA CG CTGCAAGAGA AG T CCC AG CA CAAGGAAGAG 3 00

CTGGGAGCAG TTCGTCTACG GCATGAGAAG GAGGTGCTGG GGGTGCGTGC C CG CTATGAG 3 60

CGTGAGCTCC GAGAGCTGCA TGAAGACAAG AAGCGTCAGG AGGAGGAGCT CCGTGGGCAG 4 20

ATCCGGGAGG AGAAGGCCCG GACACGGGAG CTGGAGACTC TCCAGCAGAC AGTGGAAGAA 4 80

CTTCAAGCTC AGGTACATTC CATGGATGGA GCCAAGGGCT GGTTTGAACG GCGCTTGAAG 540

GAAGCCGAGG AATCCCTGCA GCAGCAGCAG CAGGAACAAG AGGAAGCCCT CAAGCAGTGT 6 00

CGGGAGCAGC ACGCTGCCGA GCTGAAGGGC AAGAAGGAGG CGCTCGAG 648

(2) INFORMATION FOR SEQ ID NO: 7 51:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 266 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

<xi) SEQUENCE DESCRIPTION : SEQ ID NO: 751:

GGAAAGAATC TAAAAGAAGA GAAGCGACCG GTG CTTTTAA GGGTGTCTAA TTTTCAAAAG 60

AGACGTCTGG GAGTATTTTG CTCTGGGCGT TTGGGTGAGC AGGACCGGGG CGTTGGAGGG 120

TGCGGCGGGC TTGGGAGCAG GGAAGGTTCC GAGTCCTAGG GAGGCGGCAG CGCTCGGCTA 180

TGCCCTCTGG AGACTGGCGG GGCTG CGGGG CCGAGGGGAC CCGCGAGGGA GCCGCGCTGC 24 0

GGACGCGCTG AGCG CGGGAG CTCGAG 266

<2> INFORMATION FOR SEQ ID NO: 752:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 288 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO:752:

GAATTCGGCC TTCATGGCCT AGGATGTTTT AAGGCTAGGC CTGAGCGAGG AGGAGGCAGG 60

GGAGACCTGG CAGGTATTGA AGTACCTGGG AAGAAAGGCA ATGGGGATGG TGGTCCTGCT 120

CCAAGATGAT AAGTGGAGGC TGAGCGTCAC TGGTACTGGG GGCCATGATC CCCAGGGCCA 180

CCCTGGCACC AGGGTGCAGG GGATG CGGGG CCTGAG CAGG AAGAACAGAG ATCTGCGGGC 240

TGCACCGACC CATCCCTGCC CCTAGGCTGA AGAACGG CAT CACTCGAG 2 88

(2) INFORMATION FOR SEQ ID NO: 753:

(i) ' SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 87 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:753:

GAATTCGGCC TTCATGGCCT ACTGAATTTG CTTTTCTTGC CTCTCTTTAG TCACCTGTCA 60
CAGGAGGTTC CTGCTCAGTA ATGATATTGT GAGTTAGGAT AATAACTTTT TTTTTTTTGT 120

341

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GCTTCAGATT TAGAAGAAAA GATCCTGTTT CCATTTGAAA GGAACTGTAA GCTTTTATCT 18 0

TTTAACCAAC TGAACAATAC ACCAAAAGCA GCCTAGGGAT GAGCATTTCT TTGAAAGCAA 24 0

TTAGGTTATT CACCTGGTAT TAAAACTATT TACTG TTAAA AAATCTGTGA CTTCATGAAG 3 00

TTGATTTTTA AAGG C AG CAT CAAAAACTGA AAAGGAAGGG AAAAAATAGG CAGCTTCTCT 3 60

GCACTTGTTT GGAGCTCCCC AAAACAGGAG CCATGGAGAA GTGGCATCAA GACCGGGCTG 420

CCCTTTCGAG AACACCCTGT GGCAGTTCAG AGACACGCTT TTCCTACACT GCATGCAGCC 48 0

GCTCGAG 48 7

(2) INFORMATION FOR SEQ ID NO: 754:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 443 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 754:

GCTGGGTTTA GGCGATCCTC TTGCTTCAGC CTCCCAAGAA GCTGGAGCCA CAGGCATGCA 6 0

CCACCACGCC CAGTTAATTT TTGTATTTTT TGTGGGGACG GGGTCTCACT TTGTTGCCCA 12 0

GGCTTATCTG GAACTCCTGG TTTCAGGCAG TTCTCCTTCC TTAACCTCCC AAAGTGCTGA 18 0

GATTATAGGT GTGTGTGAGC TATCACACCT GGCCTAGAAA ATTATAAGAA AATATTAATC 24 0

ACATAATCTC ACTACCCATT GATGATTTAA CATCTAGTAT ATACATATGT ATATATAATT 3 00

TTAAAAGTAG GGTTATATTA TATAATTACT TCATTATTCT TGTTTTCCAC TTAATATACT 3 50

TAAGATATCT TTCAAAATCA CTAAATACAG GAACATAGTA TATCATCTTT CAGTAGCCTC 4 20

ATTGTATAGC TAACCCCCTC GAG 443

(2) INFORMATION FOR SEQ ID NO:755:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 584 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 755:

GAATTCGGCC TTCATGGCCT ATTGATTTCC TGGGCTCAGG AGAGGATGGG GAAGGGGCTC 6 0

CAGACCCTCG GCGGTGCACT GTGGATGGGA GCCCCCATGA GCTGGAAAGC CGTCGGGTCA 12 0

AACTCCAAGG CATTCTGGCT GACCTGCGGG ATGTGGATGG GCTGCCCCCA AAAGTGACTG 180

GCCCGCCTCC TGGCACACCC CAGCCCCGGC CACATGAAGG TTCCTTTGGC TTCTCCTCAG 240

ACGTCTTCAT CATGGACACT ATCGGGGGCG GGGAGGTGAG CCTGGGGGAC TTGGCAGATC 300

TCACCGTCAC CAACGACAAC GACCTCAGCT GCGATCTGTC TGACAGCAAA GATGCTTTTA 360

AGAAGACGTG GAAC CCCAAG TTCACCCTGC GCTCGCACTA CGACGGCATT CGTTCCCTGG 420

CCTTCCACCA CAGCCAGTCG GCTCTGCTCA CCGCCTCCGA GGACGGCACG CTCAAGCTCT 480

GGAACCTGCA GAAGGCGGTC ACGGCCAAGA AGAATGCGGC GCTAGATGTG GAACCTATAC 54 0

ATGCTTTCCG GGCTCACAGG GGCCCAGTGT TGGCTGG AC T CGAG 584

(2) INFORMATION FOR SEQ ID NO: 756:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 285 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

342

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION • SEQ ID NO: 756:

GAAATTAAAA AAATAAAATC AAGTTCTTGG GTGGTGGGAA ATTGGCCTGT ATTTTTTCTT 60

CTCAGTGGAA TTTGCTGAGT AAAAAATTAT AGGCTCAAAA ACTGAGAACT TTGAAGATAT 120

TGCACCATAT TCTTTTTGTA TTGAGTGTTG CTGATGAGAA GTCTGAGGTC AGTCTGTTGC 1B0

TTGCTCTTTC TAGGTAAACT GTGCTTTTTA TATTTTTTCC CCTCTAGAGG TTTTGAGAAT 24 0

TTACTCCTTA TCCATGTTAT TCTTAAATTT CACCACATTC TCGAG 285

(2) INFORMATION FOR SEQ ID NO: 757:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 310 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 757:

GAATTCGGCC TTCATGGCCT AGAATG CTTT GAATCCATAT CTTTTTCAGA AACATACATG 60

GAAATACAGA ACTACACCTG TAATTACAGA GGGCATATGA ACCCTAGTTT GATAAGCCTT 120

GCTTTAAAGG ATGCAGTGTG TTCTATTAAA TGTATTTAAT ACAATTG CAG AAATGGAAAA 180

TGTGGACCTC CATTAAACAA ATTTTTTAGT TCCTAATGAG ATAAACTTGG GACCAAACCG 24 0

ATTCCTCTTG TTTTAGTGCT CAAAAATAGT TTCATTTTTA GGTATTTATG CTTTAGTGGC 300

CTTTCTCGAG 310

(2) INFORMATION FOR SEQ ID NO: 758:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 196 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 758:

GAATTCGGCC AAAGAGGCCT AAGAAAAGAA AGCAAGAACA GAAAACGAAG CCACAGGAAG 60

GGAAGTAGAC ATTGTATGCT TATGGTTTCT CATTATGAAG GTGCAGCTTG TAGGAGGTTT 120

GTACGGATGT GCTTTGAAGT TATGTATATT ACATATAACA GGAAAAAATA TTAAAATAAA 180

CAGTGCTGGT CTCGAG 196

(2) INFORMATION FOR SEQ ID NO: 759:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 360 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 759:

343

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GAATTCGGCC TTCATGGCCT ACAGCAAATC TGCCTTCACA TGGTCTGCAT TCTAGTGGAG 60

AAGTCAGATA GAGGTAAGTA CGAAGACCAC AAAGCAGGTT AAAAAGTAAG GTGGGAAAGG 12 0

GATGCTATTT TAGACAAGGT GGTCAGGGCA AGCCTCTCAG AAGAGGGGAT AAGTGCTCAG 180

AGACCTGACT GAAGTGAGAG TGAGCTATTG ACACGGAGAA GGGCATTTCA GACTCTGAAG 24 0

AGAAAGCAGG GGCAGGCTTT GGAGGGAGAG CTTGTTTATG TAGACAAG G A GGGGCAAAGA 300

GTCTTGTGGA TAAAGCAGAA TGAACAAGAG TAAATGGGAT TGTAAATGAA ATGACTCGAG 3 60

(2) INFORMATION FOR SEQ ID NO: 760:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 192 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 760:

GGACATATGC AGT CAAAAGT AGGTGCCCAT ATATATAATG AAATACCAAA AGGACAATTT 60

AGAAGGTTGA ATGGAAACAT TATGGCATGC TTTAGACGTT CTGTTTTGGT TTTCTTATTC 120

CCAGTCTTTG ATCTTTTAGG TCTATCCATT GGTAAAGATA TATTAGGACT CACATCAACT 180

CAAGGTCTCG AG 192

(2) INFORMATION FOR SEQ ID NO: 761:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 326 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 761:

GAATTCGGCC TTCATGGCCT AGTTTATTGC TCCCAACTAT ACAT CTTCAG ACTTCACTTA 60

GCATGTTACG GGTGGTTAGG TTCCAGGATT ATTGAGATCT ATTTCTACTC ACAATTGCTT 12 0

ATAAAATGAA ATCTATCGTC ACCTTAATTG CCTGTGCCTA AAAATATAGC ATGCTTGTCT 180

TGTGGGAAAT ATTCAGCCTG GTATGTGAGT GACTGAAATG CAACT CCGTG GAAACACCCC 24 0

AACTCCACAC ATTCATCCCC TTGGTAACTC AG CACAGTCA CAGAAACTGA AGAAGTAAAA 300

TGATCCTCTT TATTTGGCTT CTCGAG 326

(2) INFORMATION FOR SEQ ,ID NO: 762:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 05 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 762:

GAATTCGGCC TTCATGGCCT ACTGGCCCAA GTGAAACTTT TAACAGGCTT TTTGGAGATC 60

TCTTTAGCTA GATCCAAAAA TTCATCAGGT ATATTTTCTG TTTTCCAAGT TCATGCAGGC 120

AATAGCTTTG CTAATATATA ATACTAGTTG CCTTGTTCAA GCTGCCATAT CAGTTTCATC 180

ACTCCTTTCC CAGTGCCCAC TCGAG 205

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(2) INFORMATION FOR SEQ ID NO: 76 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 285 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76 3:

GAATTCGGCC TTCATGGCCT AAAAATGAAT ATATTCCTAT CCTATATTAA GACACTTTCC 6 0

CTAACCTAAA AGTTTATTCT GTTTTTAAAA TAAATGAAAG TATTTGTATG GGCCCTGGGC 120

CTGACGGAGA TATGCCCTGC CCCCTCTCTA GAGTGCTGGG AATTCTCAGG TG AC CCAGTC 18 0

CCACAGGCAG CCAAGTGCCC ACACATTTCC AGGCTGCCCT CCACCAGGGC AGCGACCTCG 24 0

GGTCACCAGG GACACGCACA CCTAGAAAGC CGTGGGCTCC TCGAG 28 5

(2) INFORMATION FOR SEQ ID NO: 764:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 345 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 764 :

AATTCTTTAT CATTTCAGAT ATTAAGGATT TCAGATTTTA AGAGTTATCA GTGAAACTGT 60

GTTACAAGAA TATTTTGTTC CTGAGACATC TCAGTATTAT AGGTGGCTTC AGACTAACAG 120

G CACAGAAT A GGATAGTGTG AAGTATCTGA TTAGCTTTAC TGTACTTGGT AC CTTTAGG A 180

CGTTCAGCCA GAGGTGATTG GAGGGATTTG CACGTCTACC ACTCGTGTGT GT AT CTGTG A 240

ACCATATCTC CTTTAGTGCC TGCTTTTGAA CTTTATATAA ACAGAATGAT GCTGCCTGTT 300

TATCTCTATA ATTTTCTTCT TTCCCTTAGC ACGTGCTCAC TCGAG 34 5

(2) INFORMATION FOR SEQ ID NO: 765:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 100 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76 5:

GAATTCGGCC TTCATGGCCT AGAGAATGTT TTCATGTTAC TTATACTAAC ATTAGTTCTT
CTATAGGGTG ATAGATTGGT CCAATTGGGT GTATCTCGAG

(2) INFORMATION FOR SEQ ID NO: 766:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

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(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 76 6:

GGATTGAATT CTAGACCCTG CCTCGTCATT GTGGAACCCA TGGAGCAGTT TGATGATGAA 6 0

GATGGCTTGC CAGAGAAGCT GATGCAGAAA ACT C AACAAT ATCATAAGGA AAGAGAACAA 12 0

CCACCACGTT TTGCTCAACC TGGGACATTT GAATTTGAGT ATGCATCTCG ATGGAAGGCT 180

CTTGATGAAA TGGAAAAGCA GCAGCGTGAG CAGG TTGAT A GAAACATCAG AGAAGCCAAA 24 0

GAGAAACTGG AGGCAGAAAT GGAAGCAGCT AGGCATGAAC ACCAATTAAT GCTAATGAGG 3 00

CAAGATCTAA TGAGGCGTCA AGAAGAACTC GAG 333

(2) INFORMATION FOR SEQ ID NO: 767:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76 7:

GAATTCGGCC TTCATGGCCT AGATAATATT TTATGTTCAT TGTGTGTTAG ACTGTGTTGA 60

AG TGGAAACT TTGGAACATT GTTGGAACCA GTAAGAATCC CATTCCTCAG GTATCAGGTC 120

GTTAAAGTAG TTTAAAATAA CGTATTCCTT AATTT TCCTC AGCAGGTTCC CCCTCCCTTT 180

AACT TGTGTG TATAAATATA TGTGTGTGAT GTTTTCTCTT ACAAAGATAG TACTCGAG 23 8

(2) INFORMATION FOR SEQ ID NO: 768:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 234 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:768:

GAATTCGGCC TTCATGGCCT AGGGATCCCA CCTTTTACAT CCTAGGTGTG AACAGATTCA 6 0

AATCCACTAT TCCTCCAGAT TTTATAGATG AGGAAAC CAA GGTG CACAAG AGGGATTTTT 120

TTGTTTTGTT TTTTGTTTTT GTTTGTTTTT GAGACAGGAT TTTGCTTTGT TGCCCAGGCT 180

GGAATGCAGT GGCACAAACA TGGCTCGCTG CAGTCTCGAA CTCCTACGCT CGAG 23 4

(2) INFORMATION FOR SEQ ID NO: 76 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 291 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76 9:

GAATTCGGCC TTCATGGCCT ACGGAATGAG AAGATGAAAA ATCAAATTAA GCAGATGATG 6 0

346

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GATGTCTCTC GGACACAGAC TGCAATATCG GTAGTTGAAG AGG AT CTAAA GCTTTTACAG 12 0

CTTAAGCTAA GAGCCTCCGT GTCCACTAAA TGTAACCTGG AAG AC CAGGT AAAGAAATTG 18 0

GAAGATGACC GCAACTCACT ACAAGCTGCC AAAGCTGGAC TGGAAGATGA ATGCAAAACC 24 0

TTGAGGCAGA AAGTGGAGAT TCTGAATGAG CTCTATCAGC AGAATCTCGA G 2 91

(2) INFORMATION FOR SEQ ID NO: 770:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 43 2 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 770:

CGCTGCGTGC TTGTGAGACT GCCTGTTCTG GGACCAGCCC CTGGGCTCTT CCACCAAGAT 6 0

TTGGTGAGGG TCCCCCTCTG CCTCTCACAG AAGCCCCTGG CCCTGGACTG TCCTGGGGGC 12 0

AGGGACACCT GTGGCTGGGG AAGGGATGGC CAACAGCGGG AAGCAGTTTG CGCCTGGTGC 18 0

CTGATGATGG TGAACCACGA GACAGATGGA GACGGGAGTC AGGGGACCCT GGGGACCCTT 24 0

CCAGGTCCAG TGACCTTTTC CCAGACAGGC ACTCTCCAGG CCTAGGACAG ACAGGGCCCC 3 00

AACTCCTCAT CACCCCATGA CTTGGCCTGG AGGAACCTGG GGTGGGAAAC AAGTAGTCCC 3 60

CCAACCTCAG AGG CCAGAAC CACAGGTGGG GGACAGGGAC CTCGACAGAG CTGTGCCTGC 420

TCAACGCTCG AG 43 2

(2) INFORMATION FOR SEQ ID NO: 771:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 99 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 771:

GGTGTGGCTT TGCCCCGTAC GAGCGGCGCG CCATGGAGTT ACTGAAGGTC TCCAAGGACA
AACGGGCCCT CAAATTTATC AAGAAAAGGG TGGGGACGCA CATCCGCGCC AAGAGG AAG C
GGGAGGAGCT GAG CAACGTA CTGGCCGCCA TGAGGAAAGC TGCTGCCAAG AAAGACTGAG
CCCCTCCCCT GCCCTCTCCC TGAAATAAAG AACAGCTTGA CAGAAGCCCT GGCTCTCCTG
CTGTCCGTGG GTGGGTGTGG GTGTGTCGGG GGCCCGCAGT CCCCTGTCTG GTGCCCGCTC
TGAGCCACAC CCTCTCCGGG TGCTGCCTGG TCGTGAATCA AAAG CCGTGG CCCGCCCACC
CTTCCCGGGG CAGCAGGTGA GGAAGCCGCT GTACTCGAG

(2) INFORMATION FOR SEQ ID NO: 772:

U) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 520 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:772:

GAATTCGGCC TTCATGGCCT ACAAGAAAAA AGAAAAGAAA TCATTAACCC C AG CTGTGCC 60

60
120
180
240
300
360
399

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AGTTGAATCT AAACCGGATA AACCATCGGG AAAGTCAGGC ATGGATGCTG CTTTGGATGA
CTTAATAGAT ACTTTAGGAG GACCTGAAGA AACTGAAGAA GAAAATACAA CGTATACTGG
ACCAGAAGTT TCAGATCCAA TGAGTTCCAC CTACATAGAG GAATTGGGTA AAAGAGAAGT
C AC AATTCC T C C AAAATAT A GGGAACTATT GGCTAAAAAG GAAGGGATCA CAGGGCCTCC
TGCAGACTCT TCGAAACCCA TAGGGCCAGA TGATG CTATA GACGCCTTGT CATCTGACTT
CACCTGTGGG TCGCCTACAG CTG CTG G AAA GAAAACTGAA AAAGAGGAAT CTACAGAAGT
TTTAAAAGCT CAGTCAGCAG GGACAGT CAG AAGTGGTGCT CCACCCCAAG AGAAGAAAAG
AAAGGTGGAG AAGGATACAA TG AG TG AT C A AGCACTCGAG

(2) INFORMATION FOR SEQ ID NO:773:

ti) SEQUENCE CHARACTERISTICS:

(A> LENGTH: 12 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:773:

GAATTCGGCC AAAGAGGCCT AGTTTATTGT TTG CATAT AT TTTATAGTGT AGAGATTAGG
CATTTTAATA AAATTTTAAA ATTTCCAGGA TCTTACAGAA TGCTTTTATG TTACAG CTTA
CTCCTCGAG

(2) INFORMATION FOR SEQ ID NO: 7 74:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 337 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:774:

GAATTCGGCC TTCATGGCCT ACACAACGGA AAGCTGTTTT TCTGATCGAG GCTCTCTGAA
GAGCATAATG CAGTCCAACA CATTAACCAA AGATGAGGAT GTGCAGCGGG ACCTGGAGCA
CAG CCTGCAG ATGGAAGCTT ACGAGAGGAG GATTCGGAGG CTGGAACAGG AGAAGCTGGA
GCTGAGCAGG AAGCTGCAAG AGTCCACCCA GACCGTGCAG TCCCTCCACG GCTCATCTCG
GGCCCTCAGC AATTCAAACC GAGATAAAGA AATCAAAAAG CTAAATGAAG AAATCGAACG
CTTGAAGAAT AAAAT AG CAG ATTCAAACAG GCTCGAG

(2) INFORMATION FOR SEQ ID NO: 77 5:

(i) - SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:775:

GAATTCGGCC AAAGAGGCCT AGTGAGCGCG AC CAT CATGT CCATGCTCGT GGTCTTTCTC £0
TTGCTGTGGG GTGTCACCTG GGGCC CAGTG ACAGAAGCAG CCATATTTTA TGAGACG CAG 12 0

CCCAGCCTGT GGGCAGAGTC CGAATCACTG CTGAAACCCT TGGCCAATGT GACGCTGACG 180

120
180
240
300
360
420
480
520

60
120
129

60
120
180
240
300
337

348

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TGCCAGGCCC GCCTGGAGAC TCCAGACTTC CAGCTGTTCA AGAATGGGGT GGCCCAGGAG 24 0

CCTGTGCACC TTGACTCACC TGCCATCAAG CACCAG 2 76

(2) INFORMATION FOR SEQ ID NO: 7 76:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 586 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 776:

GAATTCGGCC AAAGAGGCCT ATGAAATAGA AGAAGGTAAA AATAAGGAAC AAGCAATAAA 60

CAGTTCAGAG AACATAATGG ACATCAATGA GGAACCAGGA ACAACTGAAG GTGAAGAAAT 120

CACTGAGTCA AGTAGCACTG AAGAAATGGA GGTCAGAAGT GTGGTGGCTG ATACTGACCA 180

AAAGG CTTTA GGAAGTGAAG TTCAGGATGC TTCTAAAGTC ACTACTCAGA TAGATAAAGA 240

GAAAAAAGAA ATTCCAGTGT CAATTAAAAA AGAGCCTGAA GTTACTGTAG TTTCACAGCC 300

CACTGAACCT CAGCCTGTTC TAATAC CCAG TATTAATATC AACTCTGACA GTGGAGAAAA 360

TAAAGAAGAA ATAGGTTCTT TATCAAAAAC TGAAACTATT CTGCCACCAG AATCTGAGAA 4 20

TCCAAAGGAA AATGATAATG ATTCAGGCAC TGGTTCCACT GCTGATACTA GCAGTATTGA 4 80

CTTGAATTTA TCCATCTCTA GCTTTCTAAG TAAAACTAAA GACAGTGGAT CGATATCTTT 540

ACAAGAAACA AGAAGACAAA AGAAAACATT GAAGAAAACA CTCGAG 5 86

(2) INFORMATION FOR SEQ ID NO: 777:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 63 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:777:

GAATTCGGCC TTCATGGCCT AGTTTATATA GAGTAGGTTT ACATAGAAAA GGAAAGTTCA 6 0

CTGAGATTTC TAGGTACAAG ATCTANCAAC ATGCACAAAC CAATATTGTT TATGTATAAC 120

AGCTTCAAAC AATTAGAAAT TGTAATAACC ATTATGAAAG TGATGAAAAT TGTATTGCTT 18 0

AGTATTCTAC CAAAATTATT AAGTAATTTT TTTTTTTTTT TTTNANACGG AGTCCCGCCT 240

GGGCCACAAG NGCNAAAATT TGTTTCNAAA AAAAAAAAGA AAAGAAAGAA AAAAAATTGA 300

ACTCTCAATC CCTAGATGTA AAATCAACCT CGTGTTCTTG ATTT CACCAG TAATTCATAA 3 60

CCACAACTGT TGTGTCTTGA ACACTTACTA TGCTTGGCAT ACTTATAATT TTTATTTCAC 420

TTTATCCTCA AATTTAAGAT GAAGTTTCTC CTACTAACTC GAG • 463

(2) INFORMATION FOR SEQ ID NO: 778:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 466 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 778:

349

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GAATTCGGCC TTCATGGCCT AGCTGGGAGT TACCTGNTAT CCTGATGG TG CCATGTGCTA 6 0

GCTGGGTGAC AATAACCCAG CCACCTAACA TCTCAAAGAT TGTTCCTTTT TGTGTGAAAT 12 0

AGGGATAGAG TTGTCTACTT CCCAGAGCCA GATAGAGAAC TTAAGAGATG AATCTGAAAA 18 0

TACAATAGCC TAAATAAATT CAAGGAAACA CTATTATCTT ACTGGATCTT TCCAGCAACC 24 0

ATGTTACTTT TGGCTGGATT TTGTATTTTC CAATTTGTGA ATGACACAAC AAAGAGCTAG 3 00

GTAGGTTAAG TAAATG GTTT CAGATAATAA GCCCAGTTAG CCCAGACGTT TATTTTCCAT 3 60

TTG CAT AGAA AATGAATGTT TTATGCATAC ATTTGTTTGC CCAGGGCTAG GATATTACTT 42 0

GCATATGATG TTCTTATATA ATTAAAAAAA AGAATACAAC CTCGAG 4 66

(2) INFORMATION FOR SEQ ID NO:779:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 519 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 779:

GAATTCGGCC TTCATGGCCT AATTCCACAG GGAAATGGGC AG ACTGAAC C AGTCCAGGTG 6 0

GTGAATTTTC CAAGAACATA GTTTAAGTTG ATTAAAAATG CTTTTAGAAT GCAGGAGCCT 120

ACTTCTAGCT GTATTTTTTG TATGCTTAAA TAAAAATAAA AAT TCATAAC CAAAGAGAAT 180

CCCACATTAG CTTGTTAGTA ATGCTCTGAC CAAGCCGAGA TGCCCATTCT CTTAGTGATG 24 0

GCGGCGTTAG GGTTTGAGAG AAGGGAATTT GGCTCAACTT CAG TTGAG AG GGTGCAGTCC 3 00

AGACAGCTTG ACTGCTTTTA AATGACCAAA GATGACCTGT GGTAAGCAAC CTGGGCATCT 36 0

TAGGAAGCAG TCCCTGGAGA AGGCATGTTC CCAGAAAGGT CTCTGGAGGG ACAAACTCAC 420

TCAGTAAAAC ATAATG TATC ATGAAGAAAA CTGATTCTCT ATGACATGAA ATGAAAATTT 4 80

TAATG CATTG TTATAATTAC TAATGTACGC AGACTCGAG 519

(2> INFORMATION FOR SEQ ID NO: 7 80:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 321 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 780:

GAATTCGGCC TTCATGGCCT ACTAGACCCC CGCCACAGCA GCCTCTGAAG TTGG ACAG CA 6 0

AAACCATTGC TTCACTACCC ATCGGTGTCC ATTTATAGAA TAATGTGGGA AGAAACAAAC 120

CCGTTTTATG ATTTACTCAT TATCGCCTTT TGACAGCTGT GCTGTAACAC AAGTAGATGC 180

CTGAACTTGA • ATTAATCCAC ACAT CAGTAA TGTATTCTAT CTCTCTTTAC ATTTTGGTCT 24 0

CTATACTACA TTATTAATGG GTTTTGTGTA CTG TAAAGAA TTTAGCTGTA TCAAACTAGT 3 00

GCATGAATAG ATTCTCTCGA G 321

(2) INFORMATION FOR SEQ ID NO: 781:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 560 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

350

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 781:

GAATTCGGCC TTCATGGCCT AAATGGGAAT CATCATTGCA TAACAAACCT AAAGAGAAAA 6 0

TGAGAACATT TACGAAGAAG AAACAGAGTT ACTGTACCAA GGGCAAAAAG AAAAGAAGGG 12 0

GGAAAAAAAA TAAGTCCATA AAAGAAAAAC AAAAGGAATC CATGAGCCTG GACGACAAGC 180

CGTGGGGGAT GTAAGAAGGT TTGGAACCCA AAAGG CAAGT CTAATCAGCT GGGGTAACAT 24 0

GGCGAGGCAG TTCCACATGC TGAGACTTGT GGCTACCACA TTAAAAAAGA CTGTGCATAT 3 00

T CTAAATG AC AGCAGTCCTG CAGTGACGTG GATATTCACT CTAGAAGCTA TG C AGGCAGG 360

CGTGGGAAAA GCGAAGAGAT GTTGCACCAT GCAGCTGCAA TCTTTATGTC TCTACTGGCA 42 0

CAACCGAAAA GAGTAATGTG GAAATTATCC AGAGAATTTA GGTGAGAAAA ACAGAAGCCA 480

TCAGATTTTC TCCTTTAAAT CTTCAGAGGG GTATACACTC CCCTGGAAAA CCAAGTTGCC 54 0

TCTCTGCTCA CATCCTCGAG 560

(2) INFORMATION FOR SEQ ID NO: 782:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 63 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 782:

GAATTCGGCC TTCATGGCCT AGGGGAGTCC TCATTCTGAC CTCAAAGAAA GGACTGTATT 60

GTCTGGCTCC ATAATGCAGG GGACACCAAG AG CAACAACT GAAAGCTTTG AAGATGGCCT 120

TAAATATCCC AAACAAATTA AAAGGGAAAG TCCTCCCATA CGAGCATTTG AAGGTGCCAT 180

TACCAAAGGA AAACCATATG ATGGCATCAC CACCATCAAA GAAATGGGGC GTTCCATTCA 24 0

TGAGATTCCA AGGCAAGATA TTTTAACTCA GGAAAGTCGG AAAACTCCAG AAGTGGTCCA 300

GAGCACACGG CCGATAATTG AGGGTTCCAT TTCCCAGGGC ACACCAATAA AGTTTGACAA 36 0

CAACTCAGGT CAATCTGCCA TCAAACACAA TGTCAAATCC TTAATCACGG GGCCTAGCAA 420

ACTATCCCGT GGAATGCCTC CGCTGGAAAT TGTGCCAGAG AACATAAAAG TGGTAGAACG 4 80

GGGAAAATAT GAGGATGTGA AAGCAGGCGA GACCGTGCGT TCCCGGCACA CGTCAGTGGT 54 0

AAGCTCTGGC CCCTCCGTTC TTAGGTCCAC ACTGCATGAA GCTCCCAAAG CACAACTGAG 60 0

CCCTGGGATT TATGATGACA CCAGTGTCTC GAG 63 3

(2) INFORMATION FOR SEQ ID NO:783:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 40 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:783:

AAATGACACT GAATGACACG TTAGC CAAAA CTAACAGAGA ATTATTAGAT GTGAAGAAAA 60

AATTTGAAGA TATAAATCAG GAATTTGTAA AAATAAAAGA TAAGAATGAA ATATTAAAAA 12 0

GAAACCTGGA AAACACTCAG AACCAAATAA AAG CTGAGTA CATCAGCCTG GCAGAGCACG 180

AGG CAAAG AT GAGCTCGCTA AGTCAGAGCA TGAGAAAGGT GCAGGATAGT AATG CTGAAA 240

TCTTGGCCAA CTACAGAAAA GGCCAAGAAG AGATTG TGAC ACTGCATGCC GAAATTAAAG 3 00

CCCAGAAGAA GGAGCTCGAC ACAATACAAG AATGCATTAA GGTAAAATAT GCCCCAATTG 36 0

TCAGCTTTGA GG AG TG CG AG AGAAAATTTA AAG CAACAGA GCTCGAG 4 07

(2) INFORMATION FOR SEQ ID NO: 784:

351

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 342 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 784:

GCAGAAAAGT CAGAACAATT TGAGGAGCTT CAAAGCATCC TTAAGAAAGG GAAACTAACT 6 0

TTTGAGAATA TTATGGAAAA ACTGCGAATC AAGTATTCCG AAATGTACAC CATAGTCCCT 120

GCAGAGATTG AATCCCAGGT GGAAGAATGC AG AAAAG CTT TAGAAGACAT AGATGAGAAG 180

ATTAG CAATG AAGTCTTAAA AAGCTCACCA TCATATGCAA TGAGGAGAAA AATAGAAGAA 240

ATTAACAATG GGCTTCATAA TGTTGAAAAG ATGTTGCAGC AG AAAAG CAA AAATATTGAG 3 00

AAAGCTCAAG AAATTCAAAA GAAAATGTGG GACTCACTCG AG 342

(2) INFORMATION FOR SEQ ID NO: 78 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 56 base pairs

(B) TYPE:" nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 785:

GAGATAATGG ATGAAAGGAT TCAGAGGAAA G TAG AG AAAC TAGAG CAACA ATGTCAGAAA 60

GAAG CCAAGG AATTTGCCAA GAAGGTACAA GAGCTGCAGA AAAGCAATCA GGTTGCCTTC 120

CAACATTTCC AAGAACTAGA TGAGCACATT AGCTATGTAG CAACTAAAGT CTGTCACCTT 18 0

GGAGACCAGT TAGAGGGGGT AAACACACCC AGACAACGGG CAGTGGAGGC TCAGAAATTG 240

ATGAAATACT TTAATGAGTT TCTAGATGGA GAATTGAAAT CTGATGTTTT AACAAATTCT 300

GAAAAGATAA AGGAAGCAGC AGACATCATT CAGAAGTTGC ACCTAATTGC CCAAGAGTTA 360

CCTTTTGATA GATTTTCAGA AGTTAAATCC AAAATTGCAA GTAAATACCA TGATTTAGAA 420

TGCCAGCNGA TTCAGGAGTA TACCAGTGCT CTCGAG 4 56

(2) INFORMATION FOR SEQ ID NO: 786:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 88 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 786:

GAATTCGGCC TTCATGGCCT AGGGGTGAGA GTGTAGACGG CTTTCCCAGT TGTATCCAAG 6 0

GCAGTCAGAC AGGGGGATTT GGGCTGTGTT GTGCCCCAGC GCTGCAAGGT GGCCAACAGC 12 0

GACGGCGGTC GGGGGACACC TGCAGTGAGA GGCTCCCCTC TCAGCACACT CGTCTCGCTT 180

CCCTCAGGCT TTGGCTGATT TGGATCTGGT TGCTGAACTT CCAACAATTC CTCAAAATCA 240

TCCACAAAGA ACTCCTTCAG TGGAGGGCGC TTTGGCCTCT TCAGGGTGTT CAGAAGCTGC 3 00

TGGATTTTGG AGGACACTCT GCTGTTCACA GGGACACCAT CTGCTGTTTC CAGCATGCTC 3 60

CCGCTGCACC CCCGAGGAAC ACTTCTCACA GAAGCCACCT GTGGACGCTC AAAGTACGAA 4 20

TGCTCCACGA GGCCCGTGGT GACATCAGGA GGG GCAGAAT GCAGATCTAT GTGGGTGTGG 4 80

GCCTCGAG 4 88

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(2) INFORMATION FOR SEQ ID NO: 787:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 52 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 78 7:

GAATTCGCCT TCATGGCCTA AGTGTCCGGA ACATATGTCA TGATTCTATG TCCAAACAAC 6 0

AGGCCAACCC TCAGGACAGA CCCCGCCACC CCCCTTCTCT GCAGCTCCTG GCAGGGACGG 120

TGCACAGTGG TGCCGTGTGC AGGGGGCCAG CGCAGCCACT GGGCATCTGG GGCAGCGCTG 18 0

GTCGCCTGGC CACCTCCTTG CTGGGGCCGC TGGGCCTCCG GCCTAGAAGG ACAGGAAGCC 24 0

ATCCACCTCA AGGCGCAGGA AGGGGTCCAG CAGGGCCCGG AGCTTCCAGA TGGTGG CACG 3 00

GCTCAGCAGG GGCGGCACCA GCCCCTCGAA GGGCCTGGGG TTCAC CATGT ACACGTAGGC 36 0

GACCAGCAGG GTGCCCAGCA GCAGCCTCAG GATCAGCAGC CTGAGAATCT CCAGCTGGAT 420

GTCCTCCATC TGGTCCCTAG ACCTGCCTCG AG 4 52

(2) INFORMATION FOR SEQ ID NO: 788:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 88 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:788:

GAATTCGGCC TTCATGGCCT ACAGGACAGA GGCAAATAGT AGACAAAGGT GAAGCCAAAG 60

GCATAATTAA GGAAGGAAGA ACGATATTAC CAAAAGATGA AACTGAAAAG AAAGTCTTAA 120

CTGTGTCAAA TTCTCAAATT GAAACTGAAA TTGAAGTTCC ATCGTCCGCA GTTCCAGAAC 180

ACAGAATGTA TGAAAATCAA AGTCAGGTGG TTCTTGTAGA AAAC CTTCAT GTTAACAAAA 24 0

CAAATGAAAC AATCAGACAT GAAAATAAAC CGTATGTTCC TAGTTCAGCA CAAATGACAA 300

GAAGGAAATT CCAAAAGGCT AAG C CAAATT TGGGAAGAGC ACACAGTAAG AAAGAGGAAC 3 60

CAGTTTTAGA AAAAGTCACA AACTCGAG 3 88

(2) INFORMATION FOR SEQ ID NO:7B9:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 57 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 789:

GCCTGAAGAC
GAAAAAGGGA
TTGTGGCCAA
CAAACATCGC
ATGTTGTGAA
AG CCATCTAC

ATCAAAAAGG AGGCAGCCCG GGCTTCTAGG AAGATCTGCT TTGTGTG CAA
GCTGCTATCA ACTGC CAGAA GGATCAGTGC CTCAGAAACT TCCATCTGCC
GAAAGGGGTT GCCTTTCACA ATTTTTTGGA GAGTACAAAT CATTTTGTGA
CCAACACAGA ACATCCAACA TGGGCATGTG GGGGAGGAAA GCTGCATCTT
GACTTATCCC AACAGAGTGT TGAGAACATC CAGAGCCCGT GTTGTAGTCA
CACCGCAAGT GCATACAGAA ATATGCCCAC ACATCAG CAA AGCATTTCTT

60
120
180
240
300
360

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CAAATGTCCA CAGTGTAACA ATCGAAAAGA GTTTCCTCAA GAAATG CTGA GAATGGGAAT 4 20

TCATATTCCA GACAGAGATG CTGCCTGGGA ACTCGAG 4 57

(2) INFORMATION FOR SEQ ID NO: 790:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 582 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 790:

GAATTCGGCC TTCATGGCCT AGCGGCAGCG GCTCTTCAAA GCGGAGCCGG GAGTTTTTGC 60

TACAGTTTTC GCCACCATGA GTCGCAGCTA TAATGATGAG CTGCAGTTCT TGGAGAAGAT 120

CAATAAAAAC TGCTGGAGGA TCAAGAAGGG CTTCGTGCCC AACATGCAGG TTGAAGGTGT 18 0

TTTCTATGTG AATGATGCTC TGGAGAAATT GATGTTTGAG GAATTAAGGA ATGCCTGTCG 24 0

AGGTGGTGGT GTTGGTGGCT TCCTGCCAGC CATGAAACAG ATTGGCAATG TGGCAGCCCT 3 00

GCCTGGAATT GTTCATCGAT CTATTGGGCT TCCTGATGTC CATTCAGGAT ATGGGTTTGC 360

TATTGGGAAC ATGGCAGCCT TTGATATGAA TGACCCTGAA GCAGTAGTAT CCCCAGGTGG 420

TGTCGGGTTT GACATCAACT GTGGTGTCCG CTTGCTAAGA ACCAATTTAG ATGAAAGTGA 4 80

TGTCCAGCCT GTGAAGGAGC AACTTGCCCA AGCTATGTTT GACCACATTC CTGTTGGGGT 54 0

GGGGTCAAAA GGTGTCATCC CAATGAATGA CAAAGACTCG AG 582

(2) INFORMATION FOR SEQ ID NO; 791:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 46 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 791:

GAATTCGGCC TTCATGGCCT ACATTTTCTG AGAAAGG TTT GGATGACTGA AATATTTCCT 60

CTACAG TCAA GGACTTTGGC ATGTGGTGGC TGAAACTGAG CTTTTTTGTG TGGGCTCCAG 120

TTCTCACTGT TCTGCAATGC TCATGGCAAG TTGAATGGTG AGCTAG CTTA TAAATTAAAG 180

AGCTCTGAAC TGTATTCAGA CCGACTGGGT ATCTAGCTTA CTGTTTTAAC ATCATTGTTG 240

AAACCAGACC CTGTAGTCCA GTGGTGCTGC CCTGTTGTGC AAACTGCTCC TTTTTCTCGT 3 00

GTTTTTGTAA AGAGCT TCCA TCTGGGCTGG ACCCAGTTCT TGCACATACA AGACACCGCT 3 60

GCAGTCAGCT AGGACCTTTC CGCCATGTAT TCTATTCTGT AGTAAAGCAT TTCCATCAAC 4 20

AATGCCTAAT TGTATCTGTT ATTTTTGGTT TAACACACAC TGCTCGAG 468

(2) INFORMATION FOR SEQ ID NO:792:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 519 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION; SEQ ID NO: 792:

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GAATTCGGCC TTCATGGCCT ACGTGGCTAT AACTGGAAAA CTGGATCCGA AATCGACCAG

TAAACTGGGT AGCTCGGTCT ACGCCCCGCC CACCACCCTT GCTAGCCAAT AGCCTTCACA

ACTCTTCTGC CACTCCCGCC CATTCCAGTG CTGTGCCGCT GCTTTTTCTT CCACTCGGAT

CTCTTGAGCG CCCTTAGCCO GCTGTATACG CGCCCCTCCT CGGCTTCAGT AGGCAAGAGG

GCCATCTGCC CTTCCTTCCT GAAGGTAGAG GGGACAACAC CAGCTACGAC GGGGACTCCA

GAAGTCCATC TCCCGAACAG CAGCGGGGCG AAAAGAAAGA AAAAGGGTTT CCGAAGACTC

CTACTCACAC CCACGCTTTC CCTTAACCCG GAAGTGATTT CCGCCCCTCC TCTCCCTCTT

CGGTTGATAC TGGAGGAGAA GGACGGCCAG GTCTGGCCCG GCATGCCCTG GGCTTCCGGT
GACCTCTGGC CCTTTTCTGT CGTCCACTCT CCGCTCGAG

60
120
180
240
300
360
420
480
519

(2) INFORMATION FOR SEQ ID NO: 7 93:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 8 base pairs

{B) TYPE: nucleic acid

(C) STRANDEDNESS : double

<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7 93:

GAATTCGGCC AAAGAGGCCT ACAGAAACAT CCAATTCTCA AACTGAAGCT CGCACTCTCG 60

CCTCCAGCAT GAAAGTCTCT GCCGCCCTTC TGTGCCTGCT G CTCAT AG CA GCCACCTTCA 12 0

TTCCCCAAGG GCTCGCTCAG CCAGATGCAA TCAATGCCCC AGTCACCTGC TGCTATAACT 1B0

TCACCAATAG GAAGATCTCA GTGCAGAGGC TCGCGAGCTA TAGAAGAATC ACCAGCAGCA 24 0

AGTGTCCCAA AGAAGCTGTG ATCTTCAAGA CCATTGTGGC CAAGGAGATC TGTGCTGACC 3 00

C CAAGC AGAA GTGGGTTCAG GATTCCATGA ACCTCGAG 33 8

(2) INFORMATION FOR SEQ ID NO: 794:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 756 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 794:

GAATTCGGCC AAAGAGGCCT ACCAGGATGG TCTCAATCTC CTGACCTCAT GATCTGCCTG 60

CCTCGGCCTC CCAAAGTGCT GGGATTACAG GCGTGAGCCA CCGCACCCGG CCCTAAACCC 120

TAGGTTTTGA CTTCTGTAAG AAGGAAAGAT TTAAACAAAC AAACAAACAT TAAATTACAA 180

C CAT AAT AAA CAAAAAAACA CTAAACTAAA TTACAACCAT AATAAAATCT CCCAAAGTCC 240

GTAGGCACTG ACATATTACA GCCTTGCCAA ATCAGAATAG ATTTCTCATG TGTTGTCAAT 3 00

TTACCAGACA CAAAGAGTAG CTCAGATCTC ATAGACTCTT CAGATCTTGT AGACTAATTT 36 0

CAAGTCTTTT TAAAGTTTTG AAAAACATGT GCTATTTGGA ATTACGTCAT CCTCGAATAT 420

TAAACCTGAG CTCAAAAACC TATTGTTTGA TATTGGAAAT AGTTAACTCC AGTTTTCTTC 4 80

TATTAAGATA AAATTCTTTC ATCATGTCTG TGCCCTCTAA AATAATACTC CTATTGCTTT 54 0

GTCTTCCCCT TCTCCCCTCC TAGTCCTTCT TTAGTCATTC TATTTAGAAT CAAGTCGCTC 600

ATGAGTTTAA GAATTAGAGC AG CAAG AAAT TGGGCTAGAG ATGTACAAAA GCTTTGGACA 660

ATAGTAG TTT TGCTTGTCCT CATTCTTATT AGAAGTGCTG TTAATTTACT GATAAATTCT 720

AGGACGGAAG ACAAATCTTT GCAACTGGTA CTCGAG 756

(2) INFORMATION FOR SEQ ID NO:795:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 64 8 base pairs

(B) TYPE: nucleic acid

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(C) STRANDEDNESS: double
<D> TOPOLOGY: linear

(li) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 795:

GAATTCGGCC AAAGAGGCCT ACCAGGAAGC TCTCCTGCTT GTCATGAAGT GAGAACAATG 6 0

AAAAGT CATA GCAGATACTC AGTTTAACTC TGTG TAG AA C CTATTAGTGT TTGAGCTGTT 12 0

ATTCAGATTT GAATTCAGAC TGTGTGTTGT TTGCTTATGG ACACTGCCTG TCGTTCTGTC 18 0

ACTGTTAAAT TAATGAGTCT ATAAGGTTTT TCTTCCAGAG GCCATAGGTG ACATCACTAA 24 0

AATTG CAAG A TAAATTGTAA TCTTTGNTGN TGCTGCACTC CCCAACCTCT CCCCCACCCC 3 00

CCGTGGTGTG CTGCTTTCTA GATGAGCGTG TTTTGGAGCA GGCCCATCTG GGACACTCTA 3 60

TGCTTTCACC AAGGAAGTGC GAT CTG AGCA GCCACAATCC AG CCAAAAG A GG AT CG TAG A 4 20

TATTTGCTCT GATCAACTAG ATGAAAATAT AGCAGAATGG ATTTAGCCCA CTGCTCTGTT 4 80

TTATCCAACT GAGTCTCTGA CCAGCAATTG GTG CATAATT ATTACAGCAA AAGTTAAGAA 54 0

ATGAAACTGT AG CAATTATG TAAATGAATG TGTTGGCCTC TTAATACCTG TTACTAGTGG 60 0

ACTTCCTGTG AGGAAGTTAG TTTTTTGTTT TGATGAAATG CTCTCGAG 64 8

(2) INFORMATION FOR SEQ ID NO; 796:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 610 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 796:

GAATTCGGCC AAAGAGGCCT AAGAGGCTGG CCCCAGTCCC AAGGAACAAG AGATGG TCAA 60

GTCGCTAGAG ACATATCAGG GGACATTAGG ATTGGGGAAG ACACTTGACT GCTAGAATCA 12 0

GAGGTTGGAC ACTATACATA AGAACAGGCT CACATGGGAG GCTGGAGGTG GGTACCCAGC 180

TGCTGTGGAA CGGGTATGGA CAGGTCATAA ACCTAGAGTC AGTGTCCTGT TGGTCCTAGC 240

CCATTTCAGC ACCCTGCCAC TTGGAGTGGA CCCCTCCTAC TCTTCTTAGC GCCTACCCTC 3 00

ATACCTATCT CCCTCCTCCC ATCTCCTAGG GGACTGGCGC CAAATGGTCT CTCCCTGCCA 36 0

ATTTTGGTAT CTTCTCTGGC CTCTCCAGTC CTGCTTACTC CTCTATTTTT AAAGTGCCAA 42 0

ACAAATCCCC TTCCTCTTTC TCAAAGCACA GTAATGTGGC ACTGAGCCCT ACCCAGCACC 4 80

TCAGTGAAGG GGGCCTGCTT GCTCTTTATT TTGGTCCCGG ATCCTGGGGT GGGG CAGAAA 54 0

TATTTTCTGG GCTGGGGTAG GAGGAAGGTT GTTGCAGCCA TCTACTGCTG CTGTACCCTA 6 00

GAAGCTCGAG 610

(2) INFORMATION FOR SEQ ID NO: 797:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 286 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 797:

GAATTCGGCC AAAGAGGCCT AG C CACTATC CTGGTTACTT GTGGATTCAC CAAGCAGTCC 6 0

AGCAAGTCAT CCGTAGAAAT GAATGTTTGA GGAGTCGTAG TAGTATTTGA GGCAATCTGT 120

TCCTCAATTG CATTTTCACT GTTGCTCATT ATTTGTTGTC TCTTGGCACA ATGCAATTTT 180

CCAAAGTGTT CTCCATCCTT GTCCACAAAG TCTTTCCCAT CACTTCCAAA TATGCCTCCT 24 0

356

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PCT/US98/06956

CTTTCTGAAG GCGGTTCTTC GGACCTCTGT GCTACAGGGA CTCGAG 286
(2) INFORMATION FOR SEQ ID NO: 7 98:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 163 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 798:

GAATT CGGCC AAAGAGGCCT AGTTTTTTAT TGGTTTGGAG ACT AG AG C CA ATAGTATAAT 60
GTTCTCAAAG GAAACAGACT TGAGTTGTTG GATTAGAGGA ACTAACCCAA CTTATATGAT 120
TTTTTTTTTG TTTTTGTCGT GTAGTTATGG CACTAGTCTC GAG 163

(2) INFORMATION FOR SEQ ID NO: 7 99:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 443 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 799:

GAATTCGGCC TTCATGGCCT AGAGGGAATG CGGAGAGGGG TGGAGAAATT CCATCTTTGT 60

TAGGG CAGCA GTCAAGGATG AGTG AG TTAG CCTCTTAAGG AAGAGGCTAA GCTGTTAGAA 120

TAAAGAGGTT TACAACATCA GCGGCTTAAA TCAAATAGAA GTGTGTTTCT CTTTCACATG 18 0

ACAGAGTAGA TGTGGCCTGG CATCTAGAAA GCATATTTGT CTCTGCTCCA CTGTGTCTTC 24 0

CAGGGACCCA TTCTTCTCTT GTCTTCATGC TCCATCACTT CCTAGGGTGT TGTCTACACC 300

TGCATAGCCA TAGCTAATTT TCCATTCTCA GCACCAACCA GGGGAAGAGG AGGAAAGGTA 360

GCCTCCTTTT CATGATAGGT GTGAAGTTAT GCAGGACACT CTCAGGGTGA ATGGACCACA 42 0

GTGTGGCTCC TCCTGGGCTC GAG 44 3

(2) INFORMATION FOR SEQ ID NO: 800:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 05 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 800:

G CATGTGCAG CGGCAAAGAG AACCCGGACA GTGATGCTGA CTTGGATGTG GATGGGGATG 60

ACACTCTGGA GTATGGGAAG CCACAATACA CAGAGGCTGA TGTCATCCCC TGCACAGGCG 120

AGGAGCCTGG TGAAG CCAAG GAGAGAGAGG CACTTCGGGG CGCAGTCCTA AATGGCGGCC 1B0

CTCCCAGCAC GCGCATCACA CCTGAGTTCT CTAAATGGGC CAGTGATGAG ATGCCATCCA 24 0

CCAGCAATGG TG AAAGCAG C AAGCAGGAGG CCATGCAGAA GACCTGCAAG AACGGTCGAC 3 00

TCGAG 305

(2) INFORMATION FOR SEQ ID NO: 801:

357

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PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 464 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 801:

GAATTCGGCC AAAGAGGCCT AAACACTCAA ATTTTACATT TTGAGCAGTA TTTACGCCTG 60

AATTAATTCA CAAGTTTCAA GGTCACTAAC TTTGGTTATA TTATATTATT ATTTTCCAAT 120

TTAGCCACCT CTTTATTTGT ATAATAG AG C ATACAGCAGC ACATAAAACG CAAAACTCTA 180

GGACATAAAA AGTGGCATTC GGACGATGTT GCTCTGAAAT TTATGCATTA ATTAAACCGG 24 0

TATATATGTA TGCATTAATT AAACCAATAT TTATGAAGTT CCTACTGTGT TACAGACGTG 300

GATCCAGGCA CTGAGGATGC AGCAGGCCAT CCAAATATAA AGTTACTTCC TTAGGAAGCT 3 60

TCCATTCTAA TGGGAGAGTG TTGTTAAAGA GATATATAAT AATATGTAAA ATGAAT CCAT 420

AATGGTGAGT ATTATGAAGA ATAAAATTGC CAGGTTTTCT CGAG 4 64

(2) INFORMATION FOR SEQ ID NO: 802:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 802:

GAATTCGGCC AAAGAGGCCT AATCTTCTGC CTGTTCTGAA AAAGCTTTGC TTCTTGTGAT 6 0

TTGTATCACG AGGGGGAAAG GTCCTTACTG TTTTTCCAGA CCTACAGTTG TGATAGAGGC 120

TCCTCCCAGC CCCGCCCACA GACCCCAACA GTGCCCTCTC TCACAAATGG ATTCTGGGGC 180

TTGGTCTTTA TTTTTGTTTT TGTTGGGGGC AG CATATGGA ACCCAAAAAT AG TATCATAG 24 0

CCTAAATTTG GAGCTTTGTG CCAGCCTTGT CTGTAGGATG ACCCGTGTGG GTCTCACCTG 3 00

GTGACTGGGA GTCCACAGGG GTCAGTTAGT AG CAGGGAG C TGCAGGGCGC CTGTCAGCAG 3 60

AGACCGTCTC ATTCCCCAAA CCCAGGAGCC AGAGGAACTG ACGCCCGGAT AAATGCCCAA 420

GCCGCCCCGG GTGGGATTAG TCGTCTACCT TCCCAGAAAT ACACCCTCCC ATCCTGTGAC 4 80

TTGGATACAG TTTACTGATG AAATTAGGGA ACCTCCTGCG C CTTAC CAAG AAGCTGTGGC 540

TGGAACTTAG TCAATGAAAA ATGATTTGTA AACT CTTTGG AGCTGGCTTT GAAAGAATGT 600

TTAAAATGAT AGCTGATACT GCCAGACAAC AGAACAGGCC GGCCCTCGAG 650

(2) INFORMATION FOR SEQ ID NO: 803:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 101 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 803:

GAATTCGGCC AAAGAGGCCT AAGAGAACAG GAG CATTACA GTAAAATTCC TAAGTAG CCA 6 0

ACTGATTTGC AGTGCCAGAA ATGAAT AC CG AT CCACTCGA G 101

(2) INFORMATION FOR SEQ ID NO: 804:

358

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PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 723 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 804:

(2) INFORMATION FOR SEQ ID NO: 805:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 406 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 80S:

GAATTCGGCC TTCATGGCCT ACGGCCAAAG AGGAGGAGAT GGCGCCAGTC AGGGAGCGGC 60

CGTGGCCCAG ACAGTGAGGA AGCGCGAAGG CGGAGCAACC GAGGAATCCT CCGGAGAAGA 120

ATCAGAGCCG TCGCTACCGC CACTACCGCC AC CAC CATGG AAGGAGCAAA GCCGACATTG 18 0

CAGCTCGTGT ACCAGGCAGT GCAGGCGCTT ACCACGACCC AG ATCCCAG C GGAAAGGAGC 24 0

GCGCCTCTTT TTGGCTTGGG GAGCTGCAGC GTTCGGTTCA TG CATGGG AG ATCTCAGACC 3 00

AGTTGTTACA GATCCGGCAG GATGTGGAGT CATGCTATTT TGCTGCACAG ACCATGAAAA 36 0

TGAAGATTCA GACCTCATTT TATGAGCTCC CCACAGTACT CTCGAG 406

(2) INFORMATION FOR SEQ ID NO: 806:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 329 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 806:

GAATTCGGCC TTCATGGCCT ACGCCCGGGT TGGAAGTGTG CAGTCAATGA GCTCCCGCTC 6 0

CTCCTGGATC CGTCTGTAGG TCTCCCCGGT GTG CATGAGC AGCTCACTCA CTGGCTTCTT 12 0

TAGGTGTTCG CTGAGGGCTT CCTGCTGCTT CTTCCGCAGG GCTGTGTTAC GCTGCCAGTT 180

GAATTCGGCC AAAGAGGCCT
AAGATTACAA TGAAC CAACT
AGTACAGATG AGG CTAATAC
CCCAGAAGCT GCAAGGAAAT
CTCCGCACTG AGAATGGTGT
GGCTGGACCC TGGTGGCCAG
GATCGCTGGT CCAGTCAGCA
GCCAACTACA ACACCTTTGG
GGCTACTACG ACATCCAGGC
ATGCAGCACT GGAGAAACAG
ACACTGGGAC ATAATCTGTT
AAGTGTTGGA CTGACAACGG
GAG

AGCTCTCTGT ACCCAAGGAA AGTGCAGCTG AGACTCAGAC
CAGCTTCCTG CTGTTTCTCA TAG CGACCAC CAGAGGATGG
TTACTTCAAG GAATGGACCT GTTCTTCGTC TCCATCTCTG
CAAAGACGAA TGTCCTAGTG CATTTGATGG CCTGTATTTT
TATCTACCAG AC CTTCTGTG ACATGACCTC TGGGGGTGGC
CGTGCATGAG AATGACATGC GTGGGAAGTG CACGGTGGGC
GGGCAGCAAA GCAGACTACC CAGAGGGGGA CGGCAACTGG
ATCTGCAGAG GCGGCCACGA GCGATGACTA CAAGAACCCT
CAAGGACCTG GGCATCTGGC ACGTGCCCAA TAAGTCCCCC
CTCCCTGCTG AGGTACCGCA CGGACACTGG CTTCCTCCAG
TGGCATCTAC CAGAAATATC CAGTGAAATA TGGAGAAGGA
CCCGGTGATC CCTGTGGTCT ATGATTTTGG CGACATCCTC

60
120
180
240
300
360
420
480
540
600
660
720
723

359

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PCTAJS98/06956

TTTCAGAAAG TTGTGCTGAG GAGGTGGGGC CCAGGGAGGT CTCTTCTCTT CTTTTGGGGC 24 0

TTTTTGCTTT GACTCTCCTT CAGCAGAGAT GAG GGT CATC AGACAGGGTG AGGTAGGTAT 3 00

CCGCTCAGCC AGCTGGGTGT TCCCTCGAG 32 9

(2) INFORMATION FOR SEQ ID NO: 807:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 225 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 807:

GAATTCGGCC TTCATGGCCT AAGGTACTTT AATCAGTCTA AATACTTGAA CATTTTTATT 60

TCAGTGGTAA AAAATAGACT GAGGCAGAGT GAAG TTATAA ATTAGAATCT AAAAATTTAC 120

CCTTCAACAT TAATATTTTT TAGTGCTCTA ATATAAAACA CAGAAAACCT ATCT CAAAT A 180

TAAAAGATGA ATATAAAATT ATTAATTAAA CAACTGGCGC TCGAG 225

(2) INFORMATION FOR SEQ ID NO: 808:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 275 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 808:

GAATTCGGCC TTCATGGCCT AACTTGCTCT TCTGTTTCTA GTTTTATAAA GTGAAAGCTG 60

CAATCATTGA TTAGAGACAG TTCTACGCTA AAG TCATAAT GACATTTTAT GTAATTTCTT 120

TTTTCTTTTT TTTGAGACAG AGTCTCGCTC TGTTGCTCAG GCTGGAGTGC AG TGGAGTGA 180

TCTCAGCTCA CTGCAACCTC TGCCTCCCAG GTTCAAGCGA TTCTCCTGCC TCAGCCTCCC 240

GAGTAGCTGG GATTACAGGC CCCCACCAAC TCGAG 275

(2) INFORMATION FOR SEQ ID NO: 809:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 53 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 809:

GCGATTGAAT TCTAGTTGCC TACCTACCAA ACTACCTACT GAACTTTTTA ATTTGAAGAT 60

ATTCTTCCTG GACTACTTGT TTATAGTTTA TTAAATGAAC TGCTCTATTT CTAAAAACTT 120

TATTTTTAAA GTCCTTTCCC GTTTAGAATG CGGCATACTC TTGCTTGTGG GGTATATATC 180

TCTGATCGTG ATAACTACCT AC CGAAAACC TTTCATGGCT CCTTGCCAAC TACAAAATTG 240

CGATATCCTC GAG 253

(2) INFORMATION FOR SEQ ID NO: 810:

360

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PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 283 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 810:

GAATTCGGCC TTCATGGCCT AGATTGAATT CTAGACCTGC CGACGCGGGG AGAGACAAAA 60

AAGAGAAAGT CTTTGAAAAG CACAAGGAGA AGAAGGATAA AGAGTCCACA GAAAAGTACA 12 0

AGGACAGGAA GGACAGAGCC TCAGTGGACT CCACGCAAGA TAAGAAAAAT AAACAGAAGC 18 0

TCCCCGAGAA GGCTGAAAAG AAGCACG CTG CCGAAGACAA GG CTAAAAG C AAACACAAAG 24 0

AGAAGTCGGA CAAAGAACAT TCCAAGGAGA GGAAGTCCTC GAG 28 3

(2) INFORMATION FOR SEQ ID NO: 811:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 316 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 811:

GAATTCGGCC AAAGAGGCCT AGGCTTCCAC CCAGGAAATG ATCCAGAGCC TCTTTTATGT 6 0

TATGTTTTTT GTTTGTTCCT TTCAAGACAA TCGATCAAGC CAGAGGCATT CCCCACCCTT 120

CAGCAAGACA CTTCCCAGTA AGCCCAGCTG GCCTTCAGAG AAAGCAAGGC TCACCTCCAC 180

CCTGCCGGCC CTGACTGCTT TGCAGAAACC TCAAGTCCCA CCCAAACCCA AAGGCCTCCT 24 0

TGAGGATGAG GCTGATTATG TGGTCCCCGT GGAAGATAAT GATGAAAACT ATATTCATCC 300

CACAGAAAAG CTCGAG 316

(2) INFORMATION FOR SEQ ID NO: 812:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 256 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 812:

GGGATGCATA GATTTAGTTC TGCCTCACAG GCAGGTAGCC TGAGCTCCTA GGGGGAACTG 6 0

TTTTTGCTAA GTAGGGAATG AAAAG CATGT TTATTTAAGC ACAAAATTAA ATCTCTCCTA 120

TTTTTATATG ATTTCCCGTT GTTTTCTTCC CTGTAGGGAA ATCTGCTGTG ATAGAGAACT 180

GCGTAACAGG CCTTTTCTGT GAGCGCTCAC TCATACATTA TGCACGACGT GGCTAAGATC 24 0

TTTGATGGCA CTCGAG 256

(2) INFORMATION FOR SEQ ID NO: 813:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 317 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

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(D) TOPOLOGY: linear
(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:813:

GCAAGCGGCG CATGCAGGAG GAGAAGCAGA AGTCTGTCAA CGTCAAGAAG ACCATCCTGG 6 0

AGATG CGCTA CGGGGCTGAT GTGGATGCCG GCTCCATTGT GCACGCCGCC CAGAAGCTGG 120

GCGAGCCTCC CGTGCTGCCC GTATCTCGCA TGGCCTCCAT CCCCTCCATG ATCGGGGAGA 180

AGCTGCCCAC CG CC AAGGGG TTGGAGGCCG GGCTGGACAC AC C CAAGGT A GCCACCAAAG 24 0

G CAAC TAT AT CGAGGTGCGC ACAGGCGCCG GCGGGGACGG TCTGGCTCGG CCCGAGGATG 30 0

ACCTCCCGGA CCTCGAG 317

(2) INFORMATION FOR SEQ ID NO: 814:

(i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 370 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 814:

GAATTCGGCC TTCATGGCCT ACGAACTCCT GACCTCAAGT GATCGGCCTG CCTCAGCCTC 6 0

CTAAAGTGCT GGGATAGCCA CTGTGCCCAG CCTAGCCCTT CTTCAAATGT TTGGTAAAAT 12 0

TCAGCATTGA AGCCATCAGG TCTTGGGCTT TTTGCTGGGA GATTTTTTAT TATGGCATCA 180

ATCTCATTAC TTGTTACTGG CCTGTTTAGG TTTTCAGTTT TTTCATGGTT CAATCTTGGT 24 0

AGGTTGTTTG TGTCTAGGAA TGTATCTGTT TCTTCTAGGT TTTCCAGTTT CTTGGCGTAT 300

AGTTACTCAT AGTAG CCACT AATTATCCTT TGGATTTCTG CGGTATTGGT TGTAGTGTCC 360

CCATCTCGAG 3 70

(2) INFORMATION FOR SEQ ID NO: 815:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 815:

GAATTCGGCC TTCATGGCCT AATTGAATTC TAGACCTGCC TCAAGCCTAT CTTTTAGTCT 6 0

TCCTAGAAGC ACCGTGTTCT GTGGAACTCA GCAT CAGCAG CTTTGCTGAG GACTCCCCCA 120

TCTTCCTTTC CTTCCCCGGA AAGCACAGAC CTAAGTGAGT CTTCACTGGA TCCCAGCTAA 18 0

CAGCTTCTGC CCATTCCTAT CTTTCCACAG AGCCAGTGGC AGCCCCAGCT GCAGCAG CTA 24 0

CGTGACATGG GCATCCAGGA CGATGAGCTG AGCCTGCGGG CCCTGCAGGC CACCGGTGGG 300

GACATCCAAG CAGCCCTGGA GCTCATCTTT GCTGGAGGAG CCCCATGAAC TCCCTGCTTC 360

CCCTGAACCC CCAGCACTCG AG 3 82

(2) INFORMATION FOR SEQ ID NO: 816:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 274 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

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(D) TOPOLOGY : linear
(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 816:

GCCACGGTGC T CATT C AG AC TACCCGTGTG CCCAAGCAGG TGGCAGTACC CGCGACAGAC 6 0

ACCACTGACA AGATG CAG AC CAG CCTGG AT GAAGTCATGA AGACCACCAA GATCATCATT 12 0

GGCTGCTTTG TGGCAGTGAC TCTGCTAGCT GCCGCCATGT TGATTGTCTT CTATAAACTT 180

CGTAAGCGGC ACCAGCAGCG GAGTACAGTC ACAGCCGCCC GGACTGTTGA GATAATCCAG 24 0

GTGGACGAAG ACATCCCAGC TGCAACATCT CGAG 274

(2) INFORMATION FOR SEQ ID NO: 817:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 56 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 817:

GAATTCGGCC TTCATGGCCT ACAAAAATAC ACCTGTGGTC CCAGCTGCTC GGGAGGCTGA 60

NTTACGAGAG TCCCTTGAAC CTGGGAGGCG GAGGTTGCAG TG AG CTG AAA TCATG CCACT 120

GCACTCCAGC CTGGGCAACA GAG CGAG ACT CTGTTNAAAA AAAAAAAAAT AGCGAGAGAT 180

CGAGAGAGAG TGCACGTGAG AAGACTAGTA GTTGCTATGG ACTGGGGGAG AAGGAACGGG 24 0

TTACAGGGTT TCTTTTGGGG ATAACGAAAA TGTTCTAAAA CTGGACTGTG GTGATAACTG 300

CACAACTCTG TGAATGTACT AAAAACTACT GAACTGGCCG GGCGCGGCAG CTCGAG 3 56

(2) INFORMATION FOR SEQ ID NO: 818:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 184 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:818:

GAATTCGGCC TTCATGGCCT AGGCAGGGTG TCAACTTATT TAATTCTAAA AATAGTATAT 60

TCATAGAGAT ACTATCATCC TCATTTCATA TATTCAAAAA ATT CAAAGAA GTTAAGTAAA 120

TTGCCAAAAG. TCACCCAGAT AATAAGTAGA AAAGATGGTA ATGAAATCCA GGTTGGCCTT 180

CGAG 184

(2) INFORMATION FOR SEQ ID NO: 819:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 349 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 819 :

363

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GAATTCGGCC TTCATGGCCT ACAACAACAA CAACAAAAAA ACATCATCCG GGGAAGCTTT 6 0

TCAATATCCT GACGTTGGGT CTCTCCAGTG TAGATGGAAA TATGGAATTG GGAATAGACA 12 0

TCGATATTTT TGGAGGTCCC CAGGGGTTAC CAATGTGCAG ACAGGTTTGG GAACCACTGC 180

ATTAGGCATT TTACATTTAT TTAGGGCTTT CACTGGATTT GTCACCCCAT ACTTTCATAA 24 0

TCCATTTTTT CTGATTTTTT TTCTGGTTTT TGGTGAGGGT ATAGTTGGGA TGGGGTTTTT 3 00

TTTTTTGTCC TCCCACCGCT CGCCCCCATC CAG TGTGGAC GTACTCGAG 34 9

(2) INFORMATION FOR SEQ ID NO: 820:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 16 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 820:

GAATTCGGCC TTCATGGCCT ACTCTTTCCT TGAAGAATTT GTTGAAGACT TCAGAAGTGA 60
TGCTGGCTGC TTTCTTCATT AGGTTGAGCT CCCCATCCTC CTTTACAGCG ATGGTATATG 120
CCACAACTGC ACTGATATCT ATTTTGTCAA AG C CTTCAGG TCTCGAG 167

(2) INFORMATION FOR SEQ ID NO: 821:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 73 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 821:

GAATTCGGCC AAAGAGGCCT AG CG AAATAA AACAAGGGAG TCAG CAAAAC CAGAAATTTC 6 0

AG CAATG TCA GCTCATGACA AGGCTGCATT AT CAG AAG AG GAACTGGAGA GGAAGTCGAA 120

ATCTAT CATT GATGAATTTC TACACATTAA TGATTTTAAG GAAGCCATGC AGTGTGTGGA 180

AGAGCTGAAT GCCCAGGGCC TACTACATGT TTTTGTGAGA GTGGGAGTGG AGTCCACCCT 24 0

GGAAAGGAGC CAGATCACCA GGGAT CAC AT GGGCCAACTA CTCTATCAGC TGGTACAGTC 3 00

AGAAAAACTC AG CAAAGAG G ACTTTTTCAA AGGTTTTTCA GAAACTTTGG AATTGGCAGA 36 0

TGACATGGCC ATTGATATTC CCCATATTTG GTTGTACCTT GCTGAACTGG TGACCCCCAT 42 0

GTTAAAAGAA GGTGGAATCT CCATGAGAGA ACTTACCATA GAATTTAGCA AACCTTTACT 4 80

TCCTGTTGGA AGAGCTGGGG TCTTGCTATC TGAAATATTG CACCTACTAT GCAAACAAAT 54 0

GAG C CAT AAG AAAGTGGGAG CCTTATGGAG GGAGGCTGAC CTCAGCTGGA AGGACTTTTT 600

AC CAGAAGG A GAAGATGTAC ATAATTTTCT TTTGGAG CAG AAGTTGGACT TCATAGAGTC 660

TGACAGTCCC TGTTCCTCTG AAGCACTTTC AAAGAAAGAA CTGTCTGCCG AAG AG CTGTA 720

TAAGCGACTC GAG 73 3

(2) INFORMATION FOR SEQ ID NO: 822:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 512 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 822:

TGCCAGATAG TTCTGCAGAA GAAATCACTG TTTGTCCTGA GACACAGGTA AGTTCCTCTG 6 0

AAACTTTTGA C CTTGAAAG A GAAGTCTCTC CAGGTAGCAG AGATATCTTG GATGGAGTCA 12 0

GAATAATAAT GGCAGATAAG GAGGTTGGTA ACAAGGAAGA TGCTGAGAAG GAAGTAGCTA 180

TTTCTACCTT CTCATCCAGT AACCAGGTAT CCTGCCCGCT ATGTGACCAA TGCTTTCCAC 24 0

CCACAAAGAT TGAACGACAT GCCATGTACT GCAATGGTCT GATGGAGGAA GATACAGTAT 3 00

TGACTCGGAG ACAAAAAGAG GCCAAGACCA AGAGTGACAG TGGGACAGCT GCCCAGACTT 3 60

CTCTAGACAT TGACAAGAAT GAGAAGTGTT ACCTCTGTAA ATCCCTGGTC CCATTTAGAG 4 20

AGTATCAGTG TCATGTGGAC TCCTGTCTCC AGCTTGCAAA GGCTGACCAA GGAGATGGAC 4 80

CTGAAGGGAG TGGAAGAGCA CGTTCGCTCG AG 512

(2) INFORMATION FOR SEQ ID NO:823:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 423 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:823:

GAATTCGGGC CTTCATGGCC TACTCTCATC TGTATCTGTT TCCTCTAACT TTACTGAAAA 6 0

GATAGAATTC ATTAAGCATG AATTCTACCA TCTTCTCCCT ACTACAGCTC TGTCAAAAAG 120

ATGTTGCTCT CTGAGCCCAA CTCTCCCTCA GTCCCCAGGA TTCTGTCCCT GTCCACCTTT 180

AATCTTTTCC TTTCCTGATT TTATGTTATA AGTTATTTAG ATTTCGATGA GAGATAATCG 24 0

TACCTAGAGT ATGGGAGAAC TATTTAAGGT TTACAGGTTG GGTGGAACCC TTGTATATAC 3 00

TAGATGGTAC TGTGAGGGCT TGCCACACTG TCAGCCTTCA TCTGAACAGA GCAGAAAGTG 360

TTTCTGCATG TTCACCAAGC CCTGCTGGAC TGTATCACTT TTCTCTGTGG GCCAAAACTC 420

GAG 423

(2) INFORMATION FOR SEQ ID NO: 824:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 53 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 824:

GAATTCGGCC TTCATGGCCT AGCGGCCTCA GATGAATGCG GCTGTTAAGA CCTGCAATAA 6 0

TCCAGAATGG CTACTCTGAT CTATGTTGAT AAGGAAAATG GAGAACCAGG CACCCGTGTG 120

GTTGCTAAGG ATGGGCTGAA GCTGGGGTCT GGACCTTCAA TCAAAGCCTT AGATGGGAGA 18 0

TCTCAAGTTT CAACACCACG TTTTGGCAAA ACGTTCGATG CCCCACCAGC CTTACCTAAA 24 0

GCTACTAGAA AGGCTTTGGG AACTGTCAAC AGAGCTACAG AAAAGTCTGT AAAGACCAAG 3 00

GGACCCCTCA AACAAAAACA GCCAAGCTTT TCTGCCAAAA AGATGATCTC GAG 3 53

(2) INFORMATION FOR SEQ ID NO: 825:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 506 base pairs
(B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

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(ii) MOLECULE TYPE: CDNA

Ui) SEQUENCE DESCRIPTION; SEQ ID NO:825:

GAATTCGGCC AAAGAGGCCT AGGAGTAAGG ATGCAGAAAT GATTGCAGCA TATTTCATTC 60

TCTACGCAAG GATGTTCCTC GGAAATGGAG GCGACATTGC TGCCTGCTTT TTTGAGGGAA 120

TTGATGATGT TCACTGGAAG GAAAATGGGA CAT TAG T T CA AGTAGCAACT ATATCAGGAA 180

ACATGTTCAA CCAAATGGCA AAGTGGGTGA AACAGGACAA TGAAACAGGA ATTTATTATG 24 0

AGACATGGAA TGTAAAAGCC AG C CCAGAAA AGGGGGCAGA GACATGGTTT GATTCCTACG 3 00

ACTGTTCCAA ATTTGTGTTA AGGACCTTTA ACAAGTTGGC TGAATTTGGA GCAGAGTTCA 3 60

AGAACATAGA AACCAACTAT ACAAGAATAT TTCTTTACAG TGGAGAACCT ACTTATCTGG 4 20

GAAATGAAAC ATCTGTTTTT GGGC CAACAG GAAACAAGAC TCTTGGTTTA GCCATAAAAA 4 80

GATTTTATTA CCCCTTCAAC CTCGAG 506

(2) INFORMATION FOR SEQ ID NO:B26:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 337 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 82 6:

GATGGAGCAG TTCCAGAAGG AGAAGGAGGA ACTGGACAGG GGCTGCCGCG AGTGCAAGCG 60

CAAGGTGGCC GAGTGCCAGA GGAAACTGAA GGAGCTGGAG GTGGCCGAGG GCGGCAAGGC 120

AGAGCTGGAG CGCCTGCAGG CCGAGGCACA GCAGCTGCGC AAGGAGGAGC GGAGCTGGGA 180

GCAGAAGCTG GAGGAGATGC GCAAGAAGGA GAAGAG CATG CCCTGGAACG TGGACACGCT 240

CAGCAAAGAC GGCTTCAGCA AGAGCATGGT AAATACCAAG CCCGAGAAGA CGGAGGAGGA 3 00

CTCAGAGGAG GTGAGGGAGC AGAAACACAA G CTCGAG 33 7

(2) INFORMATION FOR SEQ ID NO: 827:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 216 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 827:

GAATTCGGCC AAAGAGGCCT ACAGGTACAG AATCATATGA ATGTTTCTTT CTTTCTTTCT 6 0

TTTCTTTCCT TCTTTCCTTC TTTCTTTCTT TCTTTTTTTG AGACAGAGTC TTGTTCTGTT 12 0

GCCAGACTGG AGTGCAGTGA CTCAATCTCA GCTCACTGCA ACCTCCACCT CCCAGGTTCA 180

AGCAATTGTC CTCCCTCAGC GAGGACCTGC CTCGAG 216

{2> INFORMATION FOR SEQ ID NO: 82 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 386 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 82 8:

GAATTCGGCC AAAGAGGCCT AAAAAAAAGA AGATGGGTTT TTTAAGTCCA ATATATG TTA 60

TTTTCTTCTT TTTTGGAGTC AAAGTACATT GCCAATATGA AACT TATCAG TGGGATGAAG 120

ACTATGACCA AGAGCCAGAT GATGATTACC AAACAGGATT CCCATTTCGT CAAAATGTAG 180

ACTACGGAGT TCCTTTTCAT CAGTATACTT TAGGCTGTGT CAGTGAATGC TTCTGTCCAA 24 0

CTAACTTTCC ATCATCAATG TACTGTGATA ATCGCAAACT CAAGACTATC CCAAATATTC 3 00

CGATGCACAT TCAGCAACTC TACCTTCAGT TCAATGAAAT TGAGGCTGTG ACTGCAAATT 360

CATTCATCAA TGCAACTCAT CTCGAG 3 86

(2) INFORMATION FOR SEQ ID NO: 82 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 93 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 829:

GAATTCGGCC AAAGAGGCCT AGCTGAATCC TAGATTTCAG CTTCTCACTC AGAATTTAAG 60

CTGTTTTCAG T AC CAGAAAT ATTTAAGACT GTTAGTTTAA CTTCTAAGAA TAG CAG ATAA 120

AG CGTATAGG TGTTTTGAGA TAAC CGTATT CATAGGAAAA ACAAACATAA AACTTTCATA 180

ATTTTGGGAA GAGTTACACA CAAAAATATC ATCATTGAAT AATTAGTACA ACAAAAATGC 24 0

ATTTGTTTGT CCTAAAGGTT GAAATGAACA GAATCATGAT GGGAATACTC GAG 2 93

(2) INFORMATION FOR SEQ ID NO: 83 0:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 146 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83 0:

GAATTCGGCC AAAGAGGCCT AATTGAATTC TAG ACCTG C C TATGTCCTAT TCCCTGTGTC 60
CTGCAAGACC CCCTTTGGTT TGGTTTTCTT TTCTTTTCTT TTTTTCTTTT TTGAGACTGC 120
GTCTTGCTCT GTCTCCCAGG CTCGAG 146

(2) INFORMATION FOR SEQ ID NO: 831:

(i) ' SEQUENCE CHARACTERISTICS :

(A) LENGTH: 158 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 831:

GCGATTGAAT TCTAGACCTG CCTCTCATCC ACTATTGTCT TTCCCCAATT TTTTTCTAGC 6 0

CTTATCTTCC AGAATTC CTC TCAGACATAG GTGGCCCTGG TTGCTTGATC CTGTCTCTAA 120

367

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GTTGGTCTTT CATGTTTTCT CTCCTCAGAT TGCTCGAG 158
(2) INFORMATION FOR SEQ ID NO: 832:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 317 base pairs

<B) TYPE: nucleic acid

<C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 832:

GAATTCGGCC TTCATGGCCT AGCTGATTTA AATCTAAAAA CTGGATAAGA AGCTGTGGCT 6 0

TGTAATTAAA AATAGACCTT TATTCACTAG ACCTACAGTT TGCTTTTTTC ATATGTTAAG 120

AAAAGTTTAA TATCCTGCT J CTCTATTTCA GTTCTAGGGG CACCACTATC AGTTAACCCT 1B0

AAAGATTTCT GTG GGTG AAA CCATTTTGAT TACCATCTTG CTCTGCTGCC AGTTATGGTA 240

ACCAAACTCT CTTTGTTTCT GGATGCTAAA TCTGTCCACT TGTGCCTTAA CTACATCCTA 3 00

ACTCCCGTCA ACTCGAG 317

(2) INFORMATION FOR SEQ ID NO: 833:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 833:

GAATTCGGCC TTCATGGCCT AGCCCCCGGA GCCCACCACA GTCCCCAGAG TGTGATAAAA 60

ACAATTTTTA TACTTCTTAT CTCTTTCTAG TAGTCTACAT CCCATTCCCA GTCTTTCCAA 120

TCATAAAAAT TTGTAGTTTA TTTAGTTCAC ACTTGAACGT CCTATGAAAC TGTTTTAAAC 180

CTTTTACCTA TCTTGTTTCT TGTCATTATT CTTAAGCCAT TGATACAGAA ATCAGAACCA 240

AATTTAATAT TGTTGTGGGT ATGAGACAGT TTCTGTCATG TTTTAATTTT TTCCTTAAAG 3 00

TTTTACTATG TACTTCATAT ATACCGGGCA CTTCTCGAG 33 9

(2) INFORMATION FOR SEQ ID NO: 834:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 96 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 834:

GAATTCGGCC TCATGGCCTA TGACTTTTAA GTTTCTTATT ACACTGAGAA ACACCTAACT 60

ATCCTAATAG AATTAAATTT CCCTAAGTTA TAAGACACTT GAATTTTTTA AAAAGAGATA 120

ATTAAATTTC TCCTATATTT TATTTCATTT ATTTTTTCAG TCATGCTCCT TCTGTATCTC 180

CTATATTTTA TTATATTACT TACATGGCTT TATTTTTACA ATAACTCTTT TTTTCCCTTC 240

TTTTATTTAT TTGTTTATTT TTGGAAACAG AGTTTCCTTA TGCTGCCCAC GCTGGTCCTG 3 00

AGCTCAAGCA ATCTTCACGC CTCAGCCTCC CAAAATTATA GGACTACAGG CATGAGCCAC 360

TGTGCCTGGC CTAAGCCACT GCACCCGGCG CTCGAG 396

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(2) INFORMATION FOR SEQ ID NO: 83 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 94 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83 5:

GAATTCGGCC TTCATGGCCT ACTTTTACTC ATGCATAATT TTGTAAAATC CTACATTGGT 60

CATTTGGAAA ATATTGATTC ACTGAGTAAT ACAACTCTTC CAAATGTTGA ATGTTTCATT 12 0

CTACAATATC AGAAACTCAA TTTGTTAATG TTACTAC TAG T CTCATCAG A AATGTCTTTA 18 0

AGTATTTGTT AACTGGCAAA CTCATAGTGA CGACTACAGG CTTTCCAGAA TTTTCATTTT 240

CATTTGAAGT CTGAATTTTA TCAACTATAA AT ACTGT CAG TTGTTTCCCT CGAG 294

(2) INFORMATION FOR SEQ ID NO: 8 36:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 352 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83 6:

GAATTCGGCC TTCATGGCCT ACTCTGATAC TAACTGTAGT CTACATTTAT ACATTGTGTC 60

TGAATGCTGG TTTTGTGGCT TCACTAGCTC CCTTTTTCTC TCTCCTTTTT TATCCTGTCT 12 0

TTTGCTGCTG CTTTCCACCT TCTGTCCAGC TCCATCTTCA GACAGCTCCC TGTATAACGC 18 0

TCCACTTCCT GAGTATTCCA GTTGCCAGCC TCCTTCAGCA CCTCCTCCAT CATACGCTAA 24 0

AGTCATCTCA GCTCCAGTGT CAGATGCCAC TCCTGATTAT GCTGTAGTGA CTGCTTTGCC 300

ACCTACTTCC ACACCCCCTA CACCACCACT GCGACACCCA GCGACACTCG AG 3 52

(2) INFORMATION FOR SEQ ID NO: 837:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 55 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:837:

GAATTCGGCC TTCATGGCCT ACCGGACCTT GAAAATGGAA TGTTCAGAAA CACATGTGCA 60

AGGGAGCTGT GCCAAGCTCA TGTTGCGAAC AGGCCTCCTG ATGAAGCTTC TCAGCGAGCA 120

GCAGGAAGCA AAGGCATTGA ATGTAGAATG GGATACGGAC CAACAAAAAA CAAATTATAT 18 0

TAATGAGAAC ATGGAACAGA ATGAACAGAA AG AG CAGAAG TCAAGTGAGC TCATGAAAGA 24 0

AGTTCCAGGA GATGACTATA AGAACAAACT CATCTTCGCA ATATCTGTGA CTGTAATACT 3 00 '

AATAATTTTG ATTATAATTT TTTGTCTTAT AGAGGTGAAT TCACATATGC TCGAG 3 55

(2) INFORMATION FOR SEQ ID NO: 83 8:

(i) SEQUENCE CHARACTERISTICS :

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(A) LENGTH: 540 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83 8:

GAATTCGGCC TTCATGGCCT AAAAAATCTA GTTGAGAAAA AGAAAGAAAC CAAGAAGGCT 6 0

AATCACAAGG GTTCTGAAAA TAAAACTGAT TTAGATAATT CTATAGGAAT TAAAAAAATG 12 0

AAAACCTCAT GTAAATTTAA GATAGATTCA AACATAAGTC CGAAGAAGGA TAGCAAAGAA 180

TTTACACAAA AAAATAAGAA AGAGAAAAAA AACATTGTTC AACATACTAC AGACTCTTCT 24 0

C TCGAAG AAA AACAAAGGAC ATTAGACTCA GGCACCTCTG AAATTGTGAA ATCTCCCAGA 3 00

ATCGAGTGTT CTAAGACAAG AAGAGAAATG CAATCAGTGG TTCAACTCAT AATGACAAGA 360

GACAGTGATG GTTATGAAAA CTCAACAGAT GGTGAAATGT GTGACAAAGA TGCTCTGGAG 42 0

GAAGATTCAG AAAGCGTTAG TGAAATAGGA AGTGATGAGG AATCTGAAAA TGAAATTACA 480

AGTGTTGGTA GAGCTTCAGG TGATGACGAT GGAAGTGAAG ATGATGAAGA GAAGCTCGAG 540

(2) INFORMATION FOR SEQ ID NO: 83 9;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 53 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 83 9:

GAATTCGGCC TTCATGGCCT AGCATTTCAT CTCTAAATTG GGGAGAATAG AAGCATCTAC 60

TTCATGTAGT AG CCAGGATT AGAAGAGGGA GGAATAACTG GGCCCTGGAT AGAATGTGAT 120

GAATGTATAT TCTTAATGAG AAGTGGAAAT AATTTGTGGT TGAGAGCTGT GCCTCAGATC 180

AGAGTGACAG GATACATGGC TAGGCTATAT TTTCCAGCAG ATTAAGAGCT GCAGCCCAAG 240

ACTCTGAAAT ATGAAGAAAA AAGGAGAAGA TGACAGCATA TCTTTTTAAA GAAATATTTT 300

CCAGCCAAAT GGTGCAGCAG AGGACTTCCA GGAATTTGTT CTTGTTCTGT ATCAAAGGTG 36 0

AAGAGTTCGT AGCCTTCAAG GAAACAAGAA ACCATGGGAT GGAGTGAAGG AAGGTGGCCT 420

GGAACCAGCT GCTGAGCCTC TCTGAGCCCC AGTTTCCTCG TCTCTAAAAT GGGGCTGATC 4 80

TCCTCTCCCT CAGACTGTTG TTGCAGGAAT TAAAACAGGT GTTGAGTGGG CTGCTCGAG 53 9

.(2) .INFORMATION FOR SEQ ID NO: 840:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 840:

TTCCACAGCT CTGATATTCA GTAACCCATG TGGAGAACAA AAGGATTTTG CTCCATGAAG 60

TCTAATTGCC TGCTGAATAA ATAAATAAAT AGATGAAGCA CTG CATG CAT TAAATGAAAG 120

TAAATATTGA CCCTGCCACC ATATGTTTGC TGGGGTG CTG GCTGAAGTGT GCTGGCAGGT 180

CCAATCAGTC AGAGTCTGCC AGCCCAGCAA GCAGGAGAGA CAGGAATATC AAAAAGGCGC 24 0

TCCTGCTTGT GCCTTAATCT TTGTCCAACC CCCAATTCCT CCACCACAGG CCTCGAG 2 97

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(2) INFORMATION FOR SEQ ID NO: 841:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 366 base pairs

<B ) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 841:

GAATTCGGCC TTCATGGCCT AC CTTATT AG TGATTGGCGA TTCAGGCCAT GTCATAGGGC 60

CTTTCAGACA AAAGGTTCTT ATCCCAGTCA GCTGGCCAAA ACATTAACTT TGGATTTCTT 120

ACCCTGCTAC AGCATCTTCT AGAAAGGCAG CAAGATAATA TTGTGGCAGT GCACAGATAA 180

CATCAGGGTA GACTTGACTG GAGAAAACCA AATTCTGCGC TTGCTCCTGT GTGCCCCCAT 24 0

CCAGCTGTGC ATGCACACAC AGGACACCTT TCTAGTATGA AGAACTTGCA TCATGTCTGC 3 00

CCTCTATTGA GCACCCCCTT CTAGAAATAC TTCCAAGTAT TAG CATG TG A ACTGTTGACT 3 60

CTCGAG 3 66

(2) INFORMATION FOR SEQ ID NO: 842:

(i) SEQUENCE CHARACTERISTICS:

(h) LENGTH: 190 base pairs
(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 842:

GCGATTGAAT TCTAGACCTG CCTCGAGCTG ACTTATGAAT TCTTTCTGTG TG AT CGTAAA 60

AGTGCAGAGT TTATTG CAAA GAGAATCTTC ATCTGAATCC TCAGCCTGGG AATCTTCCTC 120

TTCCACCGCC AACTCCTCCA CCCAGTCTGA GTCTACTTCA ATGGCCCGCT CTTCCCCATC 180

CGCACTCGAG 190

(2) INFORMATION FOR SEQ ID NO: 843:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 627 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 843:

GAATTCGGGC TTCATGGCCT AAGCT CCGCG AGCCCCCTAC AACTCGTTTC CTTCCGTTCA 60

CCTTCGCAGG GCGGCGACTG GCGGCGCGAT GGACCTGACC GGGCTCCTGC TGGACGAAGA 120

AGGCACCTTC TCCCTCGCCG GCTTCCAGGA CTTCACGTTC CTCCCAGGAC ACCAGAAGCT 180

GAGTGCCCGG ATCCGAAGGA GGCTCTACTA TGGCTGGGAT TGGGAAGCCG ACTGTAGCCT 240

GGAGGAGCTC TCCAGCCCGG TGGCAGACAT TGCTGTCGAA CTGCTCCAGA AGGCAGCCCC 3 00

CAGCCCTATT CGCCGACTCC AGAAGAAATA CGTAGCTCAT GTGTCCCGGG AGGCATGCAT 360

CTCCCCATGT GCTATGATGC TGGCTCTGGT GTACATTGAA CGGCTCCGGC ACCGAAACCC 4 20

AGACTACTTG CAGCATGTGT CATCCTCTGA CTTGTTCCTG ATCTC CATG A TGGTGGCCAG 4 80

TAAGTACCTC TATGATGAAG GGGAGGAGGA GGAGGTCTTC AACGACGAAT GGGGAGCTGC S4 0

TGGGGGTGTG GCCGTGCCCA CTCTCAATGC CTTGGAGAGG GGCTTCCTGA GTGCCATGGA 6 00

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TTGGCATCTC TACACTGAAC GCTCGAG 62 7

(2) INFORMATION FOR SEQ IB NO: 844:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 05 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY : linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 844:

GAATTCGGCC TTCATGGCCT ACCTGAGCTG CCGAAGCCGC CGTCCTGCTC TCCCGCGTGG 6 0

GCTTCTCTAA TTCCATTGTT TTTTTTAGAT TCTCTCGGGC CTAGCCGTCC TTGGAACCCG 120

ATATTCGGGC TGGGCGGTTC CGCGGCCTGG GCCTAGGGGC TTAACAGTAG CAACAGAAGC 180

GGCGGCGGCG GCAGCAGCAG CAGCAGCAAT CTCTTCCCGA ACACGAGCAC CACAGGCGCC 24 0

CGAAGGCCGG AACAGGCGTT TAGAGAAAAT GGCAGACGAT ATTGATATTG AAGCTCTAGC 3 00

TCGAG 3 05

(2) INFORMATION FOR SEQ ID NO: 845:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 409 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84 5:

GAATTCGGCC TTCATGGCCT ACCAGAAAAA ACTTACATTG AAGAGAGGAT TCCTTGTTTT 6 0

GACTATGTGT GTTTCTGCCG TCTTAGGCAG CCAACGTATT GGTTTACATG GATCTGGAGG 120

ATTATGCACA CTAGTGTTGA GTTTCATTGC AGGGACAAAA TGGTCCCAAG AAAAGATGAA 180

AGTC CAAAAG ATTATTACGA CTGTATGGGA TATT TTTCAA CCACTTCTTT TTGGTTTAGT 240

TGGAG CAGAA GTATCTGTTT CAT CG CTTGA AT CAAAT ATT GTTGGCATAT CTGTTGCCAC 3 00

TCTAAGTTTG GCATTATGTG TT CGAATTTT AACCACATAT CTATTGATGT GCTTTGCTGG 360

TTTTAGTTTT AAGGAGAAAA TATTTATTGC TTTAGCATGC ATGCTCGAG 40 9

(2) INFORMATION FOR SEQ ID NO: 84 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 370 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 846:

GAATTCGGCC TTCATGGCCT AGGCACGGTA CATACGATTA TTATAAACAT CAGCTGCGGT 60

TCTGGG AG TG AGCTTGTGTC GTGTTAGTGC CATCTCCCTG ACAAATCTGA CCTGTACCCA 120

CATCTCAGGC TGGGAAGGAG TAGCTGGGCC TCCCTTTAAT GCAGCGGCAC TGGTTTGGGT 180

CACAAG AG CT GGTTTGATCA ACCCCTGACT CCCCCTGGCG GGAGGTGCTC GTCACATCTG 240

GGAGCCTGAG CAGAGGTGCC GGGGGCTTGG AAG CTGGAGA AATGATGGAT CTTTCTCCAG 300

GAGAAACAAT TCTTATCTTC ACATCNGCCC CGTGCTCCAA ATGAAGAGCG CGTTTGCATA 360

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GCTGCTCGAG

370

(2) INFORMATION FOR SEQ ID NO: 84 7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 504 base pairs

( B ) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84 7:

GAATTCGGCC TTCATGGCCT ACGCGCGGCC GAGCGGAGGC GGAGTCGGCG CCGAGAACAT 60

GGCTGGAGGC AAAGCTGGAA AGGACAGTGG GAAGGCCAAG GCTAAGGCAG TATCTCGCTC 120

ACAGAGAGCT GGGCTACAGT TTCCTGTGGG CCGCATCCAC AGACACTTGA AGACTCGCAC 18 0

CACAAG CCAT GGAAGGGTGG GTGCCACTGC TGCCGTGTAC AGTGCTGCGA TTCTGGAGTA 24 0

CCTCACTGCA GAGGTGCTGG AGCTGGCAGG TAATGCTTCT AAGGATCTCA AAGTAAAGCG 3 00

TATCACTCCG CGTCACTTGC AGCTTGCAAT CCGTGGTGAT GAAGAGTTGG ATTCTCTTAT 3 60

CAAGGCTACC ATAG CTGGGG GTGGTGTGAT CCCTCACATC CACAAATCTC TGATTGGAAA 420

GAAGGGACAG CAGAAAACTG CTTAGAGGGA TGCTTTAACC AACCTCTTCC TTCCCCGTCA 4 80

TTGTACTGTA ACTGGGACCT CGAG 504

(2) INFORMATION FOR SEQ ID NO: 848:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 84 8:

(2) INFORMATION FOR SEQ ID NO: 849:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 502 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 849:

GAATTCGGCC TTCATGGCCT ACATGAGCCC AGGAGTTGAA GGCTATAGCC TGGGTGACAC 60
AACAAGGCCC CATCTCTAAA AAATATATAA ATAAATAAAG TTAAGGATGC TGCGTGGTTT 120

GAATTCGGCC TTCATGGCCT AAACAAGCAG AGGGACTCCC CAGAT AG CTT CATACCCAGT
TTAGCTTTAT AACAAGTGTA GTTTTAGGCT CTGTCTTGGC ATACTTGAGA GCACAATGGC
TGCTTCAAAA CAGGCATTTG AACTCGCTGT TTAATCAAAT TCTTCTTTAA TCTAAAGTGA
GTTTCTCATA GAGAGCATAT ACACTTAACC CTTGAACAAT GTAGGGGTTG GGGTGGGGAG
TCAACCCCCT GTGAAGTAAA AATTTGCTAA TAACTTTTGA CTCCCCCAGA ACTTAACTAT
AAATAGCCTA CTATTGATTG GAAGTGTTAC CAACAGCATA CACAGTTAAC ATATATTTTG
TATG TAATAT GTGTTATCCA CTATATTCTT ACAATAAAGT TAGCAAAAGA AAAAAATGTT
ATTAGGAATC CTCGAG

60
120
180
240
300
360
420
436

373

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ATATGTTCAG AAAGAGATTG AGGTAATAAA AGAGTTTTTG GCCAGGCTCT GGCTTACACC 180

TCGGCCTCCC AGAGTGCTGG GATTACAGGC ATGAGCCACC GCGCCCAGCC GGAAGTAGGT 24 0

TTTTTGAAGA GTCAGCTGAA AACAACTGTT GCCGTATTCG GAATTTAAAA TTTTAATTTG 3 00

AAAATATTAT AACTGAGAAA TTATTGTATA TATTTATGGT ATACAGCGTG ATGTTATGAT 360

AC ATG TATAC AATGCAGAAT GATTAAATCA AG CTATTTAA CATAGCTGTC ACCTCAAATA 420

CTATTTTTGT GGTCAGAAAT TTGAAATTTA TTATCTCAGG AATTTTGAAA TGTACAATAC 4 80

ATTATTATTA ACTGTTCTCG AG 502

(2) INFORMATION FOR SEQ ID NO: 850:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 850:

GAATTCGGCC TTCATGGCCT AGATAAAAAG AAACAAAAAA GAGAAGATAT GATAAGAGAA 6 0

CAGAAGATAT AC CAT AAATA TTTGGCACAG AGACGTGAGG AAGAAAAAGC TCAGGAGAAA 12 0

GAATTTGACA GAATATTAGA GGAAGACAAG GCAAAGAAGT TGGCTGAGAA GGACAAGGAG 18 0

CTGAGACTTG AAAAGGAGGC AAGGAGACAG CTTGTGGATG AGGTCATGTG TACAAGAAAA 24 0

CTTCAAGTTC AAGAAAAGTT GCAACGAGAA GCTAAAGAAC AGGAACTCGA G 2 91

(2) INFORMATION FOR SEQ ID NO: 8 51:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 311 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:851:

GGTTCTGTAT TCTGTTGGTT GGAGTGTTCT ACTATTGTTG GGTGGAGTGT TCTATCTTCT 60

GTTGGGTGGA GTGTTCTGCT GTTGTTGGGT GGCGTGTTGT ATATTCTGTT GTTGGGTGGC 120

GTGTTGTATA TTCTGTTGTT GGGTGGCGTG TTCTATCTTC TGTTGTTGGG TGGATG GATT 180

GTTCTGTATT CTGTTGGGTG GCATGTTCTA TCTTCTGTTT TTGGGTGGAG CGTTCTATCT 24 0

TCTGTTGGGT GGCGCATTCT ATATTCTGTT GTTGGGTGGC GTGTTCTGTA TTCTGTTGTG 3 00

GGTGGCTCGA G 311

(2) INFORMATION FOR SEQ ID NO: 852:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 532 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 852:

GAATTCGGCC CTTCATGGCC TAGTCTCATC TCAGAGTACT CAGAGAAACT ATTTTTTAAT 6 0

CTCTAGATAT CAAT CAATG A ATATTTATTA TTAAATACCT GCTATGTGCC AGATGGTGTT 12 0

374

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AATTATAAGT TTGTTCTCTT TTTGTCGTGC TACTTAGGCT TTTATCATTT TGTCCTATCA 18 0

TTAGGGAAGT GGCTCCNNNN CTTACAG CTA ATTTTTTTTT CAATTTACTA ATGACTTTTT 24 0

GTGGAGGTGG GGATCTCTTC TGTTCAACAT TTTCTATGAT TCATCTCAAT CCTCCAGTGA 30 0

TTATTAAAAA ACAGTTGCAG TAAGTTCAGT CATAGGGGCA CTGGAATGAG TCCTTAAAAC 3 60

TTTATGCTGC TGCTTTTGCA ATGATGGATT GCCTGAGAAT TAAGGAAAGA TAACTACTCT 42 0

CTTGGTCACT GTATTTCCAA TCAACCATAT CCTCCCAGAA TATGATTTCT TCCCTCAGGC 480

ATTTTAGAAA AGAGACAAGA GACAGATTTT TTTTTTCAGG CAATGACTCG AG 53 2

(2) INFORMATION FOR SEQ ID NO: 853:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 415 base pairs

(B) TYPE: nucleic acid

(C) STRAND EDNESS : double
CD) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 853:

GAATTCGGCC TTCATGGCCT ACTTTTTGAT AAG CAACTAG TGGTCTCATT ATCAGAGGTC 60

CCTGAGGGGC CCTACAGGCC CCCCCAGGTT CTGCCCCCAA GATTCTAAGA GAGACCTTGT 12 0

GCTAGGGCTC TAGTCTTGAT GTTCTTTGCA TTGTTTGGAT ATGAAGCCCA GGATATGTGG 18 0

GCACAATAAG GTAAATCATG AG ATG TGAAG GAGAATGAAG AT CAGG CCAG AGGTCACCAT 24 0

TCATTGAAGA GCCAGAGAAA AAGAAAATTA GTG CACAG AT TTGTGTAGAT TTACAGAGAA 3 00

CTTCTATTTG CTGCAAGAAC TT CAT CAGG C GCTGCACCAT GCCTGATTTG GAAAGGAGCT 360

TCTTTGGGGC CTGATAGAAC TGAATTAATA TGAAGAAATT GAAGTGGCTC TCGAG 415

(2) INFORMATION FOR SEQ ID NO: 854:

(i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 324 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:854:

GAATTCGGCC TTCATGGCCT AGTAAAATTA GCTGAAAAAT AATTTTCCAA TGCAAATACT 6 0

AATGAGGGTT ATATGACCGT TGTCCAAAGC ATTTG CAGTG CTGCATGACA TTTGTCCTAA 120

AACCTGACTC TTAAAACATT CCTTGTGAAA ATAGAAATAT TCCCATGCCT AGATTCCAAA 18 0

TAATAAAAGA CACTGAGAGT GTTTTCAAAA TTAATGGACT GATTTAAATT TCACTGGAAA 24 0

GCAGCTTTTT AAAACTAAAT TGTCTGGATG TGGCCTCCCT GTGATCACTT CCAACTG CTT 3 00

ACTG CCAACT TCTGGCGGCT CGAG 324

(2) INFORMATION FOR SEQ ID NO: 855:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 616 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 855:

375

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GAATTCGGCC TTCATGGCCT AACGGCCTTC AGATGGAAGG AGGGCAGGTG CATATCTGTT 6 0

AGCAAAATCT TCACAATCAT CTTGAGTTTC TCAGCAAAGT CGGCCTGGCT GGAAATTCCT 12 0

GGCGCTGCCA TGCTGAAGGT GACCAGCAAC ACAGCCCCCA GGATGGTCAG TTGTTCCAGC 18 0

TGCAACTGGA GCTCGTGGAA GCGAGACTGG TCCATTAAAA CTGTTTCGGG GAACGGCCTC 24 0

TGGAGGTGGT CCCACTTCAG AAGCTTCAGG TAAGCGTAAT TCTGGACAGC AACAGGGCTC 3 00

AGCCTGGGCA TGTCCCCAGA GCCAGCAGCC ATTCCCCCCA CTGGCAGGGC GTGTTTATAC 360

TTCTGAGTCA TAAGGTCCTC TGAGGCTTCT TCCAGCCACT GGG TGACAAA GTCCAGGGAA 4 20

TTTGGTTGCC TCTCCAAAAT CTCTTGAAAC TTCTTCCTTT CGTATTCAAC TGACTGCTGC 4 80

ATGAGATGAG GCCTGATGCT ACTGATAGCA AAGTTGGCCA TGTCCACTTT CATTAGGTCC 540

AACACAGAAA AAATTTCTCT GAAAAGGGGC ACTATTTCCT TAATGTCCTT TAGTTTCTTA 6 00

ACTTCCTCAT CTCGAG 616

(2) INFORMATION FOR SEQ ID NO: 856:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

Ui) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 856:

GCTCTGGGTG AAAAGATCTC ACACCAATGT ACATAATGTG GCCATCCTTT CCATTTTCAA 6 0

GAAGTTGCCT TGCTTTGATA CTG CAAATTC AGTATTTGTA CACTGGAATG ATAAAAAGAT 12 0

GTTCCACTTT CTTTTCAGCC AGAAAGCTTC CTCGTTGTGT GTGTGCGTGT GTGTCCCATC 180

CTATTGCCTG TTCTTTCTAA ATCTACATTT TGTTACCTTA TCCAATACTT GCTTTAGCAA 24 0

GAACATTATG GGGCCCACCA TATTCCACAG GGCCATGCCA ACCTTTGGAA AAAAGGTAGG 3 00

TCAAG G AAG A AATCAGAACA AACCCTGTGA CCATTCCACC TCCTTGCATC TTGGGCTTGG 3 60

GTTTGGAAAC TGACCAG CAA GCTGGAGCTG CCACCACAGA GAAACATCAA AG CAAAAGGG 420

TTCCAGGACC AGAGATTAGG TAACTAGCTA CAGGCCAGAG GAATGCTTCC CTCTCTAGAT 4 80

CAACAAGCAC CCTCGAG 4 97

<2) INFORMATION FOR SEQ ID NO: 857:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 262 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 857:

GTTCATGGCC- TAGATGCTGG TTTGTTTTTG TTTTCGTTTT TTTGAGACAG TCTTGCTCTG 6 0

TGACCCGGGC TGGAGTGCAG TGGTGCGATC TCGCTCATTG CAACCTCTdC CTCCCAAGTT 12 0

CCAGCAAGTC TCCTGCCTCA GCCCCCCACC GAGTAGCTGG GACTACACGC AAGTGCCACC 180

ACGCCCAGCT ACTTTTTGTA TTTTTAGTAG AGATGGGGTT TCACCATGTT GGCCAGGCTG 24 0

GACTCGAATT CCTGACCTCG AG 262

(2) INFORMATION FOR SEQ ID NO: 858:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 8 58:

GAAACTATAA TCATCAGTAC TGTAATGAGC AATTATGAGG CCTACAAGCC TTCCACAGGA 6 0

G CTATGGG AG ATCGACTAAC GGCAATGAAA GCAGCTTTCC AG TC AC AG TA CAAGAGTCAC 12 0

TTTGTTGCAG CCAGTTTAAG TAATCAGAAG GCTGGAAGTT CTGCTGCTGG GGCAAGTGGG 18 0

TGGACTAGTG CAGGGAGCTT GAATTCTGTT CCAACTAACT CAGCACAACA GGGCCATAAC 24 0

AGTCCTGACA GCCCCGTCAC CAGTGCCGCC AAGGGCATCC CAGGCTTTGG CAATACTGGC 30 0

AACATCAGTG GTGCCCCTGT GACCTACCCG TCTGCCGGAG CCCAAGGAGT CAACAACACA 3 60

GCTTCAGGGA AT AACAG CCG AGAAGGGACT GGGGGCAGCA ACGGGAAAAG AGAGAGATAT 42 0

ACTGAGAACC GGGAACTCGA G 441

(2) INFORMATION FOR SEQ ID NO: 8 59:

( i ) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 384 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 859:

GAATTCGGCC TTCATGGCCT ACTGGTCGCC AATGTGCTGC AGGTCATGGC TCCGGAATCA 6 0

AATTGGGCTC AAACGGGGCA AGCTCCAACA CAGTGGAGCC TGGCGCTACT CCCACCTCCA 12 0

CCTTGCGGAT CTCAGAG CTG CAGGATGGCT CTGCCCACCG CACCCTGAGC TGGCCCCGCT 18 0

TGGGGCTGGC ATTGGGGGAC AGTGTGTTCT GGGCGTCTCT GCTCCTCTCT GCTGGTGCCT 24 0

GTGCCTCTGC TGGCCGCCCA CTCATAGATG TCAGAGCCAC AGGACGGCCC CGCAGAATCC 30 0

CTGCGCCGAC CCTGCCGGGG GCTGGCTTTG GTGCACATGC AACTCGTCAT CGTGGTCCCC 360

ATGGGCACCT CTGCTCTTCT CGAG 384

(2) INFORMATION FOR SEQ ID NO: 8 60:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 86 0:

GAATTCGGCC TTCATG CCTA CGTTTCCCGA GAAACCAAGC CACAAAAAGT ACAGGGCCGC 60

CCTGAAGAAG GAGAAACGAA AGAAACGTCG GCAGGAACTT GCTCGACTGA GAGACTCAGG 120

ACTCTCACAG AAGGAGGAAG AGGAGGACAC TTTTATTGAA GAACAACAAC TAGAAGAAGA 18 0

GAAGCTATTG GAAAGAGAGA GGCAAAGATT ACATGAGGAG TGGTTGCTAA GAGAGCAGAA 24 0

GGCACAAGAA GAATTCAGAA TAAAGAAGGA AAAGGAAGAG GCGGCTAAAA AAACGG CAAG 300

AAGAACAAGA GAGAAAGTTA AAGGAACAAT GGGAAGAACA GCAGAGGAAA GAGAGAGAAG 360

AGGAGGAGCA GAAACGACAG GAGAAGAAAG AAAAAGAGGA AGCTTTGCAG AAGGGCTCGA 420

G 421

(2) INFORMATION FOR SEQ ID NO: 861:

U) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 271 base pairs

(B) TYPE: nucleic acid

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(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 861:

GGATTTCTTT GGAATGGGCA AAGAAGTGGG GAATCTGCTA CTGGAAAACT CACAGCTTCT 60

GGAAACCAAA AACGCCTTGA ATGTGGTGAA GAATGACCTG ATTGCCAAGG TCGACCAGCT 12 0

GTCCGGGGAG CAGGAGGTGC TGAGGGGCGA GTTGGAGGCT GCTAAGCAGG CCAAAGTCAA 180

GCTGGAAAAC CGTATCAAGG AGCTGGAAGA GGAACTGAAA AGAGTGAAGT CCGAGGCCAT 24 0

CATCGCCCGC CGTGAACCCA AAGTTCTCGA G 271

(2) INFORMATION FOR SEQ ID NO: 862:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 288 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 862:

GCGGCTCTTT GGGAGGTGGT CAGGGGAAAA GATGGTCAGT GCTTTTTCTG GACAAATCCA 60

GGGGCCAATT GAGGTGGGGA GTCTATGAGA AGGGCCCTGT CAGCTGAGGC GAGGGAAAGG 120

GCAGAGGACC TAGAATAAAA GGATATGGCC TCTCTGTGCA CTAGCAGGAT GGGTAGGAAA 180

GGGAGATATG AAAAGACGAA ATGGGG AC CG GGTG CGGTGG CTCACGCCTG CAATCCCAGC 24 0

ACTC TGGGAG GCCAAGGCAG GCAGATCACC CGAAGTCAGG AGCTCGAG 288

(2) INFORMATION FOR SEQ ID NO: 863:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 326 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 863 :

GCTCGAGTGG AATGGGCCGA GGAGATGGAT TTGATTCTCG TGGCAAACGT GAATTTGATA 60

GGCATAGTGG AAGTGATAGA TCTTCTTTTT CACATTACAG TGGCCTGAAG CACGAGGACA 12 0

AACGTGGAGG TAGCGGATCT CACAACTGGG GAACTGTCAA AGACGAATTA ACAGAGTCCC 180

CCAAATACAT TCAGAAACAA ATATCTTATA ATTACAGTGA CTTGGATCAA TCAAATGTGA 240

CTGAGGAAAC ACCTGAAGGT GAAGAACATC ATCCAGTGGC AGACACTGAA AATAAGGAGA 300

ATGAAGTTGA AGAGGCTCTT CTCGAG 326

(2) INFORMATION FOR SEQ ID NO: 864:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 864:

GGAATGGGGA GAGGGATCTA CCAAGGTNAC AGCAGTTTTT TGAGCAGCTG GCACGTGCCT
CTGCTGCCAA CATGATGAGG TACAGAACCC AGCACAGGGA ATGCTCAGCC TGTGACTGTG
AGCTGGATGT GAGAGTCTCC TGAGGACCCT CGGTATACTC AGAGCATTTC CTCTCAGGGT
GCAGGAAGAG GAAAGCAGAG GAAGTGGACT TGAAGGACCA AAGGTGGGAT CCTAGCTGGG
CCAATCACTG AGAAGCCATG TGGTCTTGGG CAAGTCATTC CCTTCTCTGA GCCTCAGTTT
CCCCATCTGT AAAATGGAGG TAATGATACT ATGCCTACCT CATCATCATG CTGTGAAGAT
TAAATGAGTT ATGCCATGGA AGTGCTGTAC ATTACCCATT GATAATGTCT CAGTGGCCTC
TCAATGAAAT GGAGTGTGAC AGAGTGCCAC ACTCTGAAAC GGCTCATCCC CGGTGATGGT
GCTGGGACTA GAACCCGGGC AACCTCGCAG TGCCATGCCC TACTGCATCA CTACGTCCAC
CTCGAG

60
120
180
240
300
360
420
480
540
546

(2) INFORMATION FOR SEQ ID NO: 865:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 8 08 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY : linear

(ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 865:

GAATTCGG C C AAAGAGG CCT AAGGATTCAT AGTATAAATC TTTAAT TTAT CACAGTCTGT 6 0

ATTAAGTAAT ACTAAACCAC TTCGCATATA AATACATCAC AACAGTATAC TTCCGTTTAT 120

GCTATCTTGG TCTTTGTACT TTTGTTTTTG TACATTTTAC TTTGG CATAA ATGTCAAAGT 180

ACAGTATTGT TATTTAGCTT TAAATATTCA TTTGCCTCTC TCCTTAATGT AAAAAGGCTT 24 0

CTTCTCAACT TCCTGACATT TCTTG CTAAA CTATACACGT CTGCCCTGTT TTCCAACAGC 300

ACACTGTTCT GTACTGTCCC TTATTTATTT TTTTTTTTTT TTTTTTTTGG AGACGAGCTC 36 0

GTTCTTTGCC CAGGCCGGAC TGCAGTGGTG CTATTTCGGC TCACTGCAAA CTCTGCTTCC 4 20

CGGGTTCACG CCATTTTCCG GCTTCAGCTT CCCGAGTAGC TGGGACTACA GGCGCCCGCC 4 80

ACCACGCCCG GCTAATTTTT TGTATTTTTA GTAGAGATGG GGTTTCTCCG TGTTAGCCAG 54 0

GATGGTCTTG ATCTCCTGAC CTCGTGATCC GCCCACCTCG GCCTCCCAAA GTGCTGGGAT 600

TACAGGCGTG AGCCACCGCA CCTGGCCTAT TCTGTCCCTT TTTAAAGCAG TTCTCTTTTA 66 0

AAAAATTGTG GTAAGATATA AAT CACATAA AATTTGCAGT TATAACCATT TTAAAGTATA 72 0

TAATTCCATG G CATTAATT A CAGTCACAGT CTTTTACAAC TATTATTACT ATGTATTCCT 780

AAAGTTTTTT TACCCTCCCC CCCTCGAG 80 8

(2) INFORMATION FOR SEQ ID NO: 866:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 61 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 866:

GAATTCGG CC TTCATGGCCT AAAAGAAAAT GGCTTCAGTA AGTTAGGATG AAAAATGAAA 60

ATATAAAATA AAGAAGAAAA TCTCGGGGAG TTTAAAAAAA ATGCCTCAAT TTGGCAATCT 12 0

ACCTCCTCTC CCCACCCCAA ACTAAAAAAA GAAAAAAAGG TTTTCTAATG AAAATCTTTA 180

AAAATACTGT CAGTATTTTA AAATTTTCAA CAGTATTATA AAAACATTGC ATCTCCCCAC 24 0

CTCTAATATG CATATATATT TTTCCTGCTA AAATTGGTTT CTACAATTGA GTAAATGGCA 300

AATACATGAA GCAATGTCCC TAAATTT TAT AAAGAAATTA TATTTAATGC ACATTCTCGA 360

G 361

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(2) INFORMATION FOR SEQ ID NO: 86 7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 880 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi} SEQUENCE DESCRIPTION: SEQ ID NO: 867:

GAATTCGGCC AAAGAGGCCG GAATTTGG CC CTCGAAGCCA AGAATTCGGC ACGAGGAAAA 60

CAGTCTTTTA ACCTTTCAAA ATG CCACAAT GTGCATTTTA GATTGCCCTT AGTTTCCCAA 120

CTCTCAGTAT ATAGAGACTC AATTAGAAAA GAAATGGTGC TAGTAGCTTC AACCCAC TGG 18 0

TATGTATTTG AGGAACTGTT CCTGGTAGAA GGCAGTACCG TGTCCCTTGG TATTGCTACT 24 0

GTGCCTGCTA TGTTACTTCT TTATGTATAT GATATGGAAG TAACTCCTTT TATACATGTG 3 00

GAGAAGTTTC ACAGCTTTTT TTCATAGTCA TTGCATTAAA ATGTCTGCTG AGGCTGGGTG 3 60

TGGTGGCTTA CGCCGGTAAT CCCAGCACTT TGGGAGGCCA AGGTGGGTGG ATCACCTGAG 420

GTTGGGAGTT CAAGACCAGC CTGAC CAATA TGGTGAAACT CCGTCTCTAC TAAAAATACA 4 80

AAAATTAG CT GGGTATGGTG GCGCACACCT GTAATTCCAG CTCCCGCCGG G CGACTCG AC 54 0

CAAAGAGGCC GGAATTTGGC CCTCGAAGCC AAGAATTCGG CACGAGGGGT ATTTTTATTT 60 0

TTANTTNTTC TGTTTCTCTC TNGAGTGTAT AGTGTAGAGG GGGTTTCTGT CTTGAGTGTA 660

GGCCTGGAGA TTTCCCTTAT ATGGTACAAA CCAGCAATGA ATTAAGAGGT CTCTTTTCTC 7 20

CAAGATCTAG TGTTTTGTAC TAGGAGAACT CTAAAAAGTA TCTATTTCAC TGTAGTGCCA 780

AAGTACAAAT TTATTTGGAT TTATTTTTTG CCATCTTATT TTTTAATATA TTTCTTTTTC 840

TATGTTGTGC TTCTTTCCCA CCTCATCTCT CCTCCTCGAG 8 80

(2) INFORMATION FOR SEQ ID NO: 86 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 366 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 868:

GAATTCGGCC TTCATGGCCT AGTCATGGCT TTAGAATCTG GAG AAGAG TC TGACTCACTT 6 0

CTTTCCTGAG GGGATGCACT GGGTTTCACA TCAAGTTCTT GAGAGGATCC CGAACGACTT 120

CTCTGCCCCA GGGGAGTCCG AGCCACAGTT TTCTGATCAA CTGATGATTC TGACCCGCTT 180

CTTTCTCTCT GGGGGGTAAG ACACTTGTTG TTGAGCTCTG GGGATGATGG AGAACGACTC 24 0

CTCGGCCTAG GAGTCTGAGG CAAAGCTTTC GGTTCTGGGG AAGAATCACA TTCGCTTCTC 3 00

CCTCTAGATG GCGTTCTAGG TATATCTTTC ATTCCAGGAG AGGACCCAGA CAGGCTGTGC 36 0

CTCGAG 3 66

(2) INFORMATION FOR SEQ ID NO: 869:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 52 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 869:

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GAATTCGGCC TTCATGCCTA GAGGATCTTC TCCTGACCCA GCATCGCTCA TCACAATGAA 6 0

GAACCAAGAC AAAAAGAACG GGGCTGCCAA ACAATCCAAT CCAAAAAGCA GCCCAGGACA 12 0

ACCGGAAGCA GGACCCGAGG GAGCCCAGGA GCGGCCCAGC CAGGCGGCTC CTGCAGTAGA 18 0

AG CAGAAGGT CCCGGCAGCA GCCAGGCTCC TCGGAAGCCG GAGGGGGCTC AAGCCAGAAC 24 0

GGCTCAGTCT GGGGCCCTTC GTGATGTCTC TGAGGAGCTG AGCCGCCAAC TGGAAGACAT 3 00

ACTGAGCACA TACTGTGTGG ACAATAACCA GGGGGGCCCC GGCGAGGATG GGGCACAGGG 3 60

TGAGCCGGCT GAACCCGAAG ATGCAGAGAA GTCCCGGACC TATGTGGCAA GGAATGGGGA 4 20

GCCTGAACCA ACTCCAGTAG TCAATGGAGA GAAGGAACCC TCCAAGGGGG AT C CAAAC AC 4 80

AGAAGAGATC CGGCAGAGTG ACGAGGTCGG AGACCGAGAA GCCCTCGAG 52 9

(2) INFORMATION FOR SEQ ID NO: 870:

(i) SEQUENCE CHARACTERISTICS t

(A) LENGTH: 372 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 870:

GAATTCGGCC TTCATGGCCT AATTTGAGCT TCAAGTCTCC ATGTGTATAA TGTGGGGTTG 60

ATGCTGTGGT GCTCCAAGGT GTTGGGGGGT TTTAGGCAGA GTTCTTATGC TTAATATAGG 120

ATGGAAAAGT GTTCGAGCTT CTTCCCTTTT CTCTTTCTTC TCTTCATCTG ACATGAGCCT 180

GGGGTTCTAC CT CTTCCAG A TAATTCATCC TGGAGCTACT AATTCTATCT CCCCATTGAT 24 0

TTTAGTGTCC TGTCTGTTTC TAAATCTACT GGGCAGTTGG AGACATTGTC TTTTGTTCCC 3 00

TCATCTATCT TCTGTATCCA CAGTTGATAA TTGTCTATGT TTTTAGTGTG TTTTAAGGAA 3 60

ACTAGTCTCG AG 372

(2) INFORMATION FOR SEQ ID NO: 871:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 574 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 871:

GAATTCGGCC TTCATGGCCT AGGTGGTGGG TGCCTGTAGT CCCAGCTACT TGGGAGGCTG 60

AGGCAGAAGA ATTGCTTGAA CCCGGCAGGC AGAGGTTGCA GTGAGCTGAG ATCGTGCCAC 120

TGCACTCCAG CCTGGGTGAC AAGAGTGAGA CTCTGTCTCA AAGAAAAGAA ACAAAAAATT 180

ATGTACACAA ATATGGACAG CACTGGCAAG AAGTGTGGCA AAAACACATG TGGTTCTCTT 240

GTTTTGGGCT CAGACATGTG GCTGTGCCAT TACAGACCCC CGGGATTTAG AATCCTCCTT 3 00

CTGAAAGG CG TCCTGTGCAC TCGTGAGCAC CAGCCTGAAC AGATGAAAAG GCTGAGCTGG 360

AGGGGCTGGG ACACAGCCCA CCTTGACGAC AGCTGCTCCT GGCTGTGCGG GGGGGTCTCC 420

AGGAAAGGCC ATTCTCCCAC TAGGATCGCC AGGCCCTACT GAGG CTCAAG CTCCTTTGCT 4 80

GTTTGGAATC TTCCCTCCCC AGCCCCCCAG CCTCATCAAA GGCTGCCTTT TCCTGTTCAC 540

TGACCACAGC TGCTTTGACT CCATTAGCCT CGAG 574

(2) INFORMATION FOR SEQ ID NO: 872:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 528 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

381

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION:

SEQ ID NO: 672 :

GAATTCGGCG TTCATGGCCT ACCAGACTAC
TCCAGCATCC AGTGTCACCA TCATGGCTAC
TTCCAAGGCC AACGAAATCT TGGCCTCGGT
CTCACCGGGG ACTACAACCC TGGCTCAGCA
TAGAGGAGGC GGCTCAGGCA ACCCTACTAC
TGCACACACC ACTACAGTTG CAACCTCCAC
CCAGAATGGA GCAGAAGATA CAACAAATTC
AGACCTCACA TCCACTAAGG CAGAACATCT
CCCCCGACAA CCCACTTCGA CGCATCCTGT

TACGGACTCA TCTAACAAAA CAGCACCGAC
AG ATACAG CC CAGCAGAGCA CAGTCCCCAC
CAAGGCGACC ACCCTTGGTG TATCCAGTGA
AGTCGCAGGC CCAGTCAACA CTACCGTGGC
CACCATCGAG AGCCCCAAGA G C ACAAAAAG
AGCCACAGCT AAAC CTAACA CCACAAGCAG
TGGGGGGAAA AGCAGCCACA GTGTGACCAC
GACGACCCCT CACCCTACAA GTCCACTTAG
GGCCACCCCC AACTCGAG

60
120
180
240
300
360
420
480
528

(2) INFORMATION FOR SEQ ID NO: 8 73:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 611 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:873:

GAATTCGGCC TTCATGGCCT AAGCTGCACA AAACGTAGAA AGAAGACATA GCGCCTGCCA 60

GGGGAATAGG AAATGAGGGC ACTTACACAT TAATGTGAAT TAGTAATTGT GGTATAGAAA 120

TGTTTTATAG TGAAAGATTC AAATTTGCTT TTCAAGAAAA ATGCCAAAAG CTATTTAAAT 180

AATTCGAGGT TACATCG TAG GTTTTGATTT TTCTCAATTT AAGATACAGA AATACAGCAA 240

GCCTTAATAT AAAGTTTCCT AAAGTTTCTT CAAGTATTTT TTAAGGTGGA GAAATGCAGG 3 00

AATTGTATAA CCAGAATTGT TTCTG CCTTT AGCTTTTCAG AACTTGAGAT GTGGCAGCAC 3 60

TGGACTGGGT TTTTTTAAAT GTTAGGACTA GGAATGTTTG CTCTTGTTAA TTATGAATTA 420

ATTGATTATT AAGTTTAGAA TGCATTTTTA CAAGTATCTA ACTATCAAAT TGTGTTTAGT 4 80

AACTTGAGTG TATGCACAAG TTTGATCAAC AG CAAAAT AG AGTTCTGAAT TTCTTTTAAA 54 0

GTGATGATAT ATTATTTTGT GAAACTTTGT GTTTGAAAAT GTTTATTTCT GTTTATGGTG 600

TAATACTCGA G 611

(2) INFORMATION FOR SEQ ID NO: 874:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 03 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 874:

GAATTCGGCC TTCATGGCCT ACGAGCGGTG AAGGAGGAGA CCAAGGAGGA TGCTGAGGAG 60

AAGCAATAAA TCGTCTTATT TTATTTTCTT TTCCTCTCTT TCCTTTCCTT TTTTTAAAAA 120

ATTT TACCCT GCCCCTCTTT TTCGGTTTGT TTTTATTCTT TCATTTTTAC AAGGGACGTT 180

ATATAAAGAA CTGAACTCAA CATTCAGGTT GTTTTTTTTT TTGTTTCTAA GTTTTTGCCC 24 0

TATTGAAGAT GACTTCAGAA AATCCATTCC CCAGTCATGA AAATGTACTG TGCTATTCTC 3 00

GAG 3 03

(2) INFORMATION FOR SEQ ID NO: 875:

382

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(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 34 8 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
<D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:875:

GAATTCGGCC TCATGGCCTA ACGGCAGCGG CAGCCTCTGA AAAGAATCGG GGCCCAAGAA 60

AAGGCGGTCG TGTTATCGCT CCCAGGAAGG CGCGCGTCGT GCAGCAGCAA AAGCTCAAGA 120

AGAACCTAGA AGTCGGAATC. CGGAAGAAGA TCGAACATGA CGTGGTGATG AAAGCCAGCA 180

GCAGCCTGCC CAAGAAGCTG GCACTGCTGA AGGCCCCAGC CAAGAAGAAA GGGGCAGCTG 24 0

CCGCCACCTC CT CCAAGAC A CCTTCCTGAG GACGCTGGCC CCAGTGCAGG CCAACATCCC 3 00

ACCCCCTACC TCCATATGGG AC CTTG CAAG TCATCCCACT TCCTCGAG 34 8

(2) INFORMATION FOR SEQ ID NO: 876:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 586 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 876:

GAATTCGGCC AAAGAGGCCG GAATTTGGCC CTCGAAGCCA AGAATTCGGC ACGAGGAGAC 6 0

TATTTTCCAT TTCACACAAG AAATCTTTGA TTATTCAG T A AAAAGAGGAA ATATAAGAAA 120

AAAAATCAGA CTAGTCTGGC CAACATGGTC TAAAAATACA AAATT AG CCA GGCATGGTGG 180

CGGGCGCCTG TAATCCCAGC TACTTGGGAG GCCCAAGCAG GAGAATCGCT TGGACTCGGG 24 0

AGGCGGAGGT TGCAGTGAGC CGAGATCATG CCACTGCACT CCAGCCTGGC AGACAGAGCA 3 00

AGACTCCCTC TCCAAAAAAG TTAAAAAAAA AAAAGAAAAA AAAGGCCGGG TGCAGTGGTT 36 0

CGGCCTCCCA AAGTGCGGGG ATTACAGGCG TGAGCCACCA TGCCCGGCCA CTTTCTGTAT 4 20

TTTTTAATAA ATAAGAAATA CACATTTAGT AGTAGTTACA AAGATCTGTA GGCCGTAGCA 4 80

AATATTCAGT AACTGGAAGA TGCCAATGAA CATTGTTGGG TAGTATTTAA ATAACAAAAT 54 0

GTTCAAATAT TTGACAAGAT TAACAACACT ACACGGCCTT CTCGAG 5 86

(2) INFORMATION FOR SEQ ID NO: 877:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 877:

GAATTCGGCC AAAGAGGCCG GAATTTGGCC CTCGAAGCCA AGAATTCGGC ACGAGGGTAA 60

TTTTAAAAAT TTATGTATTT TCTAGCATTT GCCTCAAGGA TTGAAATTTT TTTTTTTACT 120

TGTGTTTACA GGTAGAATTC TTTATTTAAA AAGTCAGTTG AATATCAAAA CTATTTGATA 180

TTCTTCAGAC TGGAATATTA TTCTCTAGTG TAGAAGAAAA CATTTTCTGC TTACAAAACA 24 0

AATAGTAAAT ACTCTAAAAT AGGGGTTGGC AAACTTTTCT TAAATAAAAG GCCAGATGGT 300

AACTATTTTA GGTTTTGTGG GCCATGTGTT GATAACTATT TTAGGTTTTG TGGGCTACGT 360

ATGGGGTCAC TCTCCCATTC TCTCTCTCTC TCTCTCTCTC TCTCTCTCTC TCTCTCTTTC 420

383

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TGTGTGTGTG AGCGGCGCTC TCGAG 445
(2) INFORMATION FOR SEQ ID NO: 878:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 586 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 878:

GAATTCGGCC AAAGAGCCGG AATTTGGCCC TCGAAGCCAA GAATTCGGCA CGAGGGGGTC 60

TCCATTCCCC GAGAAGCCAG GGGCAGGGTG GGATGGGGAA GACCAGGAGC AG AGTCGAG C 120

CTCACAGAAG CCAGCGCGGG TCTCTGCTCA GCACCCCAGC CGGGGCTCTG GACCCAGGGT 180

AACAGCCCCA GTTCATCCCA ACCCCTCTCA GAGCCTCAAG AGGGGTAGCT CGGCTGCCGG 240

AAGAGAGGGG TGCCCTATCC CTGGCAACCC CTCCACGTAG CGTACCCCAG CACCTGCCAC 3 00

CGCCTTTGCC ATTTCTTTGA GCTTGAAGTT AACT CTCTTA G AG TCTAACT TTGGTTCATT 360

TCTGCACAGG . TACAATAGAT GACTTTATTT GTTTAAAATG TTTAATATAT ATACATACAT 420

ATATATATAT TTGTCTGTAA GAATTATGTT TTAAACAGCT GCTGTAGAGT ACCTTTTTTT 4 80

AAGTAAATCT TACAGTGGAG TATATTTTTT AAAGCACAAA ATTGGTGCCA AGACTGGGTG 54 0

AGAAATGTAC ATTACCCCCT TATTATTTTG CGTCGGATTC CTCGAG 586

(2) INFORMATION FOR SEQ ID NO: 879:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 414 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
CD) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 87 9:

GAATTCGGCC AAAGAGCCGG AATTTGGCCC TCGAAGCCAA GAATTCGGCA CGAGGGGAAA 6 0

ATCTTGTCCT AAAAATATAT GAGTTTGGGG GTAAGGGGTG GGATAGCCAA G CAAAAT C AG 120

TAATTATTTT AAAATGAACA TATGAATTTT TATTAACTTT TAGTTAAATA CAGATTTTAC 180

AACGAGGTCA GCATAAGCCT AAATCTATAT AGAGGGCTAA CTCAGGCATT GTCTTGTTTA 240

TTTGTAGACT GGATTAAAAA CAACCTGTCC TGTTTTGTCA GTTCCCAGCT TCTTCGTTTA 300

GAATAAATTA G AC CAAAAGA AGAAACGTGC TTGTCTCTGT ATACCCG CAG AATGAAGTTA 3 60

CTGTTGTTAA AACCGGATTT TTTCATTTTA CTAGGTTCCG CTCTCTCCCT CGAG 414

(2) INFORMATION FOR SEQ ID NO: 880:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 402 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 880:

GAATTCGGCC AAAGAGGCCG GAATTTGGCC TCGAAGCCAA GAATTCGGCA CGAGGGTAAT 60
TTTAAAAATT TATGTATTTT CTAGCATTTG CCTCAAGGAT TGAAATTTTT TTTTTTACTT 12 0

384

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GTGTTTACAG GTAGAATTCT TTATTTAAAA AGTCAGTTGA ATATCAAAAC TATTTGATAT 180

TCTTCAGACT GGAATATTAT TCTCTAGTGT AGAAGAAAAC ATTTTCTGCT TACAAAACAA 24 0

ATAGTAAATA CTCTAAAATA GGGGTTGGCA AACTTTTCTT AAATAAAAGG CCAGATGGTA 3 00

ACTATTTTAG GTTTTGTGGG CCATGTGTTG ATAACTATTT TAGGTTTTGT GGGCTACGTA 3 60

TGGTGTCATT CTCCTATTCT CTCTCTATCA CCTACCCTCG AG 4 02

(2) INFORMATION FOR SEQ ID NO: 881:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 52 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 881:

GAATTCGGCC AAAGAGGCCG GAATTTGGCC CTCGAAGCCA AGAATTCGGC ACGAGGGGCC 6 0

GTTTTTTTTT TTTTTTTTTT TTTTTTCNNG NNAGGCTTTC CCTAGGTGAT TTTTAATTGC 120

TATTATAAAT AAATATCCAT TTTTCCCATA AAATATTGCT ATATGTTAGT ATATTAATCT 180

TGTACTGTTA CCTTTTTCAA CTCTATTGGT TCTGATAGCT TGTCAGTTGT CTACCTTTCA 24 0

TCTTCTAGGT AAATATTTCT TACAAATAAT GAG ATTTG CT CCTACTTTCC AATTTATCTC 3 00

ATTACTTTTA CTNNTCTTAC TGCACTGGCT AGGACACCAC TACCTTCTCG AG 352

(2) INFORMATION FOR SEQ ID NO: 8 82:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 51 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

<ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 882:

TTTTTTTTTT TTTTTAACTT AAAAATAGTT GTATTTATAT TCCACAATTT GTTCAAATAC 6 0

TGGTTTTCTT ATAAACTTTC TACAGGATGT TTTTAAACAA ATTCTTCACA TTGTGTTTTG 12 0

ACTATGTACT TGCGGAATTT CAGGGAAATA GTTCTGTGTA TTTTTAATAG CTTAATTTGT 180

ACTAAAGGGA TGGTAGGTGG TCACATGCAG TCCATGTGGG ATTCTAACAT GACATTTAGT 24 0

GAGTTTTCTG ATGTGGACCA T CCCTTTG AT GCTGAAGGTA ATGCATCTGT TGAAAGAAGT 3 00

GACTGTAGAT TTGGATTACT GCTCTCTGCA TCTCCCTCTT TTCTGCTCGA G 3 51

(2) INFORMATION FOR SEQ ID NO: 8 83:

(i) ' SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 883:

GAATTCGGCC TTCATGGCAA G AAGGAGN CT TAG CATCAAA CTTTGGAAAG GGAAGCCAGA 6 0

GAAAAAGGTA GAATGGACAA GTGACACTGT GGACAATGAA CACATGGGCC GCCGTTCATC 120
CAAATGCTGC TGTATTTATG AG AAAACT CG GGCCTTTGGC GAGAGCTCCA CGGAAAGTGA 18 0

385

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TGAGGAGGAA GAAGAGGGCT GTGGCATACA CACTGTGTAC GTGGCCACCG CAAAGGACGG 24 0

GTTNTGCAAC CCTAGGACCG ACCCCCACCA CCCTTCCCCA GCTCCTGACC NTTCCCAGCC 3 00

CCCTCCAGGG CCAATGCAGC ACTAAATCCC TCTCTCCTCC AGCATT CCTG TGTCTGTCTG 3 60

GCCCTAAATG TATCCATGTG GCTACTTCTC CAGCCCCCTC CTTCCCTNTC TTCTGCCTGA 4 20

TAGAGGGAAG AGGAAGAGGA GGACGAACAG AGATCCTGAA ATTCTGACTT GCTGCTATTC 4 80

CAGAACCCAG CCTCCTGGGT TTCCCCAGTC CTCATTTTTC CTCCCAATAC CCACCCTTGT 54 0

CTCTCGAG 54 8

(2) INFORMATION FOR SEQ ID NO: 884:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:884:

GAATTCGGCC TTCATGGCCT AAAAAATACA AAAAATTAGC CGGGCGTGTT GGCGGGCGCC 6 0

TGTAGTCCCA GCTACTTGGG AGGCTGAGGC AGGAGAATGG CATGAACCTG GGAGGCGGAG 12 0

CTTGCAGTGA GCCGAGATCG CGCCACTGCA CTCCAACCTG GGAGACACAG CGAGACTCCG 18 0

TCTCCNAAAA AAAAAAAAAA AAAAAAACAC ACTTGTCTTA CAAAGACTAA CAAAAGATAC 24 0

AAAATAAAAT AACTTTACAG CATCATTAGA AAGCGAACAA AATCCTAAGA TAGATACATT 3 00

TAT CTTTCTT GTTTTAGAAC TTTTTCTGTG TAATGGAATG GAAATGCTTA ATCTTGTTTC 360

AATGTTTTCA GTGTTTGTGC TTTGTCAAAT TGAGGTTGGA TGTTAAAGCC CTTACTACTG 420

TATTATACAA AGCAGCGAAC CTCGAG 44 6

(2) INFORMATION FOR SEQ ID NO: 885:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 344 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:885:

GAATTCGGCC TTCATGGCCT AGCCGGCGCC GCCGNGTCTT CCCGGTCTCC TTTCCCGGCC 6 0

GCACAGGGTT TTATAGGATC ACATTGACAA AAGTACCATG GAGTTTTATG AGTCAGCATA 12 0

TTTTATTGTT CTTATTCCTT CAATAGTTAT TACAGTAATT TTCCTCTTCT TCTGGCTTTT 180

CATGAAAGAA ACATTATATG ATGAAGTTCT TGCAAAACAG AAAAGAGAAC AAAAG CTTAT 240

TCCTACCAAA ACAGATAAAA AGAAAGCAGA AAAGAAAAAG AATAAAAAGA AAGAAATCCA 3 00

GAATGGAAAC CTCCATGAAT CCGACTCTGA GAGTGTACCT CGAG 3 44

(2) INFORMATION FOR SEQ ID NO: 886:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 88 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 88 6:

386

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PCT/US98/06956

GAATTCGGCC TTCATGGCCT AAAAATCTAA ATTAACTGAT GAATAATTTA AAACAGAATT 6 0

TCAACATTGA GACAATGTAG AGATATATTA TGGTATAAAA TGAAGCATTT GCACGAACTT 120

TTTAGCTAAA ATTTGTTTCA AAGAAGTTGC TTTTGTTTTT AGTGTACCTT GAGTTCAACA 180

CAGATGTGAA TGCCCGCTTT TTCCAGAAGG GTTCTTGGGA GAAAACACTG GAGAAGTTCT 240

AAGCACTTTT TTTTTTTTTT TTTTTTTTTT TTTTTTTAGA GATGGTTTCT TACTCTGTTG 3 00

TTCAGGCTGG AGTGCAGTGT TGCAATCATA GCTCACTGCA GCCTTGACCT CCTGGCCTCA 3 60

AGTGATACCC CTGTCTCAGC CTCTCGAG 388

(2) INFORMATION FOR SEQ ID NO: 887:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 364 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8 87:

GCCCCAGTCT AAGGCAT TTA AAATTAAACA GCTCTTCAAC GCCCCAAGTT ATTTCATCAG 60

GCTAAGAACT TCTCCGAGAA ACGCACAAGA AGGCAGGCAA ACAGGTGGGT AGGTGAGAGG 12 0

TCACGGGGCT CCATCTGCAA GCTCCATCTA CAAGGCATCA ATCTGCGTTG TGGCAT CAAC 18 0

GTTAAAATGT TCTACAGCTT AGGGATCTTC TTGAAGCAAG GTTCCAAGCA CAAAACTAGT 24 0

ATG AC CGGAG GCTCAATTTA GAAGATGCAG CATCTGAAAA CCTTTACCCC AGGAAAGGAG 3 00

GGGTGCCTGC TGGCATTCAT GGGCTCTGGA ACAAGCATTT ATTCAAAGCT GATGGCCCCT 3 60

CGAG 3 64

(2) INFORMATION FOR SEQ ID NO: 888:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 416 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 888:

GCACCCCCAA ATGCCAGCCT CTCCTTTCTT CCCATCCACC AGTATACTGC GGGGCCATTT 6 0

CTGGTCTTTG T CCAACAGG A AACCCATTTC TGGTGGGATA TGCCTTCCAG TGCCACAGGG 120

CCACTCACCC CATGCATCTC TGTCCTGCCC GTCAGTGCTG GGACGGACAG CAAGGG CAAG 180

CCCAGTGTCT GGCGGATAGG TGGGTGGGAA CAGAGAGGGG AGAATGCCGT CCTAAGCTTC 24 0

TGCTTGGGGA TCCCCCACAC GACCTGGGTA CTGCCTGGGA AACCTGTCCT AAGTAAAACT 3 00

ATGGACCTCG CCTCGCCCAC CGGCCTGCGA AGCCAGCATC TCCGTGAAGG TGGATGGAAG 3 60

CGCCTTTGTC CTCATTTTGA GCTGCAAGCT GGGTCAGCGG CTCTGAAG CC CTCGAG 416

(2) INFORMATION FOR SEQ ID NO: 889:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 349 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8 89:

387

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GTAGGCCATG AAGGCCGAAT GGAAAAAGTC AGTTAAAGAG GACTCAGTCC CCACAGGTGC 6 0

GGAGGAGAAT GTGGTGTGTG AGTCACCAGT AGAGATTATA AAGTCCAAGG AAG TAG AATC 12 0

AGCCTTACAA ACAGTGGACC TCAACGAAGG AGATGCTGCA CCTGAACCCA CAGAAGCGAA 180

ACT CAAAAG A GAAGAAAGCA AACCAAGAAC CTCTCTGATG GCGTTTCTCA GACAAATGAC 24 0

ATCAGACTCC ACAGAAAAGA CTATCACACC GCCAGAGCCT GAACCAACAG GAGCACCACA 3 00

GAAGGGTAAA GAGGGCTCCT CGAAGGACAA GAAGTCAGCA GCTCTCGAG 34 9

(2) INFORMATION FOR SEQ ID NO: 8 90:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 719 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:890;

GAATTCGGCC TTCATGGCCT AGACCTGCCT CGAGGATGCT CTGGGTTTGC TGTAGTCGTC 60

TGTTACTGGT CNTGTTAGGA GGAGGG CCAG GGGGACCCCC ACCTGGGGCA GTCCCTTCTG 12 0

TCCCTTCAGC AGGTGGCTGA GCTGGAGCAG ACATTTTTCT GACAGAGAGA GTGAGGGTCT 18 0

GTTCCTCTCC GGAGGCTGCG GCGAGACACC CGG CGAGGG A CGCTGCGGCT GAAGTGGACG 24 0
GAACTGCCAA GCTCCGCCTC GCGCCGACTA CCCCGCGGTC TAGCTGCGCT GGGGTTTCAC " 3 00

CATGTTGGCC AGGATGGTCT CGATCTCTTG ACCTTGTGAT CTGCCTGCCT CGGCCTCCCA 360

AAGTGCTGGA ATTACAGGTA TGAGCCACTG TGCCTGACAC CTGTCAAATT ATTTTACTGT 4 20

GTTTATTTAC CATGTTTCTT TCAC TGTGGG GTCTCTGTCC TTGCTGTTTT GTTTTTCTTT 4 80

TAACTTCTTT TGTTATTTAG GAAGGTTTAT ATTAATATTT TAATTCTACA TTGGATAATT 54 0

CCTATAT CAA AACTATTGTT GACAATCAGT TACAGATGGA ACTTCGTCTA CTCTTTCTCC 600

CCTTCTCACT CCTGCTCTTT CTCCCTTTCT CACTCCAGCA GTTGACTAGT CTCATTGAAA 660

AAACAAATTG GGGCCGGCCA GGCATGATGG CTCATGCCTG TAAT CCCAGA CAACTCGAG 719

(2) INFORMATION FOR SEQ ID NO: 8 91:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 53 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 891:

GAATTCGGCC TTCATGGCCT AGATACTCCG CTGAAGATCT GATGTCACCC CAAATGCATG 60

GCTCCAGCCT CAGTTCAGCT TTCCACACTG CTTGCAGAAA TTCCTTCATT TATCTTGAGT 120

TTCTCCTCTC ACTCCCATGG TAGCTTTTCC ATTCCCACTG CCTCTTCTCA CATTTCAGTA 180

GATGAGAATA GAAGCCATAG G AAG CAAACT TCCTCAACCT CCAGCCAACC GCCGAGCGAT 24 0

GGGCATCTCT CGGGACAACT GG CAC AAG CG CCGCAAAACC GGGGGCAAGA GAAAGCCCTA 3 00

CCACAAGAAG CGGAAGTATG AGTTGGGGCG CCCAGCTGCC AACACCAAGA TTGGCCCCCG 3 60

CCGCATCCAC ACAGTCCGTG TGCGGGGAGG TAACAAGAAA TACCGTGCCC TGAGGTTGGA 4 20

CGTGGGGAAT TTCTCCTGGG GCTCAGACTC GAG 453

(2) INFORMATION FOR SEQ ID NO: 892:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

388

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 892:

GAATTCGGCC TTCATGGCCT ACCAGCCTCT GGGCTGAGGC AAAGACCTCT GAGGCCCCGT 60

CCACCCAGGA CCCCTCCACC CAGGCCTCCA CTGCGTCCTC CCCAGCCCCA GAGGAGAATG 12 0

CTCCGTCTGA AGGCCAGCGT GTGTGGGGTC AGG G AC AG AG CCCCAGGCCA GAGAACTCTC 180

TGGAGCGGGA GGAGATGGGT CCCGTGCCAG CGCACACGGA TGCCTTCCAG GACTGGGGGC 240

CTGGCAGCAT GGCCCACGTC TCTGTGGTCC CTGTCTCCTC AGAAGGGACC CCCAGCAGGG 3 00

AGCCAGTGGC TTCAGGCAGC TGGACCCCTA AGGCTGAGGA ACCCCTCGAG 3 50

(2) INFORMATION FOR SEQ ID NO: 8 93:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 67 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8 93:

AACAGGAGAT GGACAAGCTG AAGGAGCAAT ATGATGCTGA GTTGCAGGCC CTGAGGGAGA 60

GTGTGGAAGA AGCAACCAAG AATGTCGAGG TCTTGGCGAG CAGGAGCAAC ACTTCAGAGC 120

AAGACCAGGC GGGGACTGAA ATGCGCGTGA AGCTTCTGCA GGAGGAGAAT GAGAAGCTGC 180

AGGGAAGAAG CGAAGAGCTG GAGCGGAGAG TTGCTCAGCT TCAAAGGCAG ATCGAGGACC 24 0

TGAAAGG CG A TGAAGCCAAG GCGAAGGAAA CGCTGAAGAA GTACGAGGGA GAAATACGAC 3 00

AGTTAGAGGA GGCCCTTGTG CACGCCAGAA AGGAAGAAAA AGAAGCTGTG TCAGCCAGAA 3 60

GGGCCCTGGA GAATGAACTG GAGGCTGCTC AGGGAAATCT GAGTCAGACT ACCCAGGAGC 420

AGAAGCAGTT GTCTGAGAAG ' CTCAAAGAGG AGAGTGAGGC GCTCGAG 467

(2) INFORMATION FOR SEQ ID NO : 8 94:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 IS base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:894:

GAATTCGGGC TTCATGGCCT ACTCAGCTTT CCTGGTCTCC CATCTGAACT GCTTCTTTGT 60

GCACCTCTTG TTCTTTCTCT TGGCTCCCAG TCTTGATTCC TGTGATCACT CTTGCATCAC 12 0

TAATTGCACA AGTGATTTCA GGTGCAATTC TGATTAGCCT GCGTCCACAC AGTGATCGAT 180

GATCCTATGT GCCTAGAAAG GACACTGTGT GCTGCTCATG ACCTGCAACA GGAAAAAAGC 24 0

CATTTCTTGT TAGCAGTGTA AGAACCTTAG AG CAAAGGAG TTGACCTTCT GATTGAATAT 3 00

AAG CACAACC TCGAG 315

(2) INFORMATION FOR SEQ ID NO: 8 95:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 02 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

389

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 8 95:

GGGCTTAGTT AGGAGCTATG GCTAAACATC ATCCTGATTT GATCTTTTGC CGCAAGCAGG 6 0

CTGGTGTTGC CATCGGAAGA CTG TGTGAAA AATGTGATGG CAAGTGTGTG ATTTGTGACT 120

CCTATGTGCG TCCCTGCACT CTGGTGCGCA TATGTGATGA GTGTAACTAT GGATCTTACC 180

AGGGGCGCTG TGTGATCTGT GGAGGACCTG GGGTCTCTGA TGCCTATTAT TGTAAGGAGT 24 0

GCACCATCCA GGAGAAGGAC AGAGATGGCT GCCCAAAGAT TGTCAATCTG GAGGAACTCG 3 00

AG 3 02

(2) INFORMATION FOR SEQ ID NO: 896:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 73 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 896:

GAATTCGGCC TTCATGGNCT ANTCTCATTT NAAATATATC CTTACTGAAA CATCTGGAAT 60

AACGT CTG AC CAAATATCTG GGTACAGTGA TCCAGCCAAG TTGAGACATG AAATTAATCA 12 0

CCATGGCCTA CATTTTTATC TGTTTGGCTG CAATTCTGTC AAAGGCTTCT GCTCTTCATA 180

ACATTTCACT CACTAGCTCC .ATGAAGCCAT ATGATACAAA CCTTGCCTGT GTAGCCTTCA 24 0

CTTTTTTCCA AAAGAAGTCT ATTAAATG C C AATCAAGTAT CTTCTCCTCC AAGCTCAGTA 3 00

GCTCGGGCCT TCAACAGCTG TTCCCCATTC CGAT CCATCT CCCTGAGCTA CCCTGGCATT 3 60

CTTATCAGGA CACTGGAGGA ATCTATGTAT GTGCCTCTAA AGATTCAGCA CCCAAACATG 42 0

ATAGAAATCA CTGTGTTCAC ACTGTATCTC TATATCTGCC CATCCCGCTC GAG 4 73

(2) INFORMATION FOR SEQ ID NO: 897:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 594 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 897:

GCTCGAGTGA AGTGGTATCT CATTGTGGTT TGGGTTTTAA TTTTATAATA TTTTAATTTT 60

TAAAATCAAA' AGAATATACT GGGGCTGGGG TGGTGGCTCA AGCCTGTAAT CCCAGCACCC 120

TGGGGGGCCA AAGGGGGTGG ACCACCTGAG TTTATGAGTT CAAGACCAGC CTGGCCAACA 180

CGGTGAAACC CCATCTCCAC TAAACATACA AAACT CAGC C GGGTATGGTG GCAGGCACCC 24 0

GTAATCCCAG CCTCTCAGGA GGCTGAAACA GGAGAATCAC CTGATCCGGG AGGTGGAGG C 3 00

TGCCATGAGT CAGAATCACG TCACTGCACT CCAGCCTGAG AGGAGACCCG TACAAAAAAA 360

AAAAAAAAAA ATATATATAT ATACACACAC ACACACACAC ACAAGGATTT TAG ATT TG AA 4 20

AATGATGTTT TTTACTCATT TCAAAATGTA CTGTAACCTT TCTTTGGTTC TTACTGTTTT 480

CATTTAACTT TCTCTGTTTT CAAGAAAAAT TGTCTTTATT GACATTTGTA AAAAAGAATG 54 0

TGTTTTGCCC AGTTATTAAG TATTTTATTT TTATG CAATT TCAGAACACT CGAG 5 94

(2) INFORMATION FOR SEQ ID NO: 898:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 02 base pairs

390

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{B> TYPE: nucleic acid
(C) STRANDEDNESS: double
ID) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 898:

GAATTCGGCC TTCATGGCCT ACTGTACATT TTTTTTAAAG TTTGTTGAAA AGAATATTGT 60

CTTATTCTAT AAAACATTTC AAACCTAGTT AGAGATTTGT AATCAAAAAA CATTTGCGCA 120

GAAAGCAGCA CTTAGGGCTG CCTGTTCTAT ACCCTACAGT CAGACAGGAA AAGAACTGAA 180

AATGGCACCC TTCTGACATT CTGAGGCAGC TGGACTGGCA GCCAAGTAAA GGAGAGTGAT 240

GAGGTGGTGT GGGGAGGGTG GGGAGGCAGC GCGAGGGTGC TCTCCACAGG GTAGGTCTCG 3 00

AG 302

(2) INFORMATION FOR SEQ ID NO:B99;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 475 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 899:

GCGGCCTTCA TGGCCTAGTG CTTGTCAGTT TGGAAAGTCA CAGGGAGTTT ACCATTCTAT 60

AATTAGAGTA GGAGGAAAAT GAGAACCCAC TGGTAGAAGA AGAAGCAACA GTCTTCTAGG 12 0

GTCTGGCATT TGATGAGATA GGTATTCAGT TACTGTGCAT TTCCATTGTT TTTCCATGGC 180

AGAACATACG GCAGAGATTT GGGAACTCGC ATGCCTGAAG CCAGGTTATT CTTATGTTCT 24 0

GTAACTATGT TGCTCGCAGG GCTGTTGTTG TCAGAGTAGT GAGTTGTGCC CCAGACAAAT 300

GGGGTGCTGG TCTGCTCCCA CAAATCTTTA TCCCAGTCTT CATCGCAAGG AGGGCACTGC 360

CAAGTGCTCT CAGCCAGAGT CTCTTGTCTA AGGCTCCTGG TTTGGTTGAC AACATCTTGC 420

TCAATACAAC TTCTGTCATC ACAGCTTGAG ATATGATGAC TAATTTCAGC TCGAG 475

(2) INFORMATION FOR SEQ ID NO: 900:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 507 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 900: ■

GAATTCGGCC TTCATGGCCT ACAGCTGCCT TTTTCTTTAA AGGGGTTCTT GTCTTCTGGA 60

ATTCCCTTTA CTAGAGGATC CTCTCCAGAA CGTTCTTCAA TATAGTTCTT TATTTCTTCA 12 0

GAACATTTAG ACACTTGTTG TCTCTGCAAC TTCACTTCTT TGCGAAGCTG CTCAACTTCC 18 0

ATTTTCAGTT TTTCCTTCTC TGGCAAATCT TCGATGTGAA GGGCAGGCAT TTTCGCCCCA 24 0

GAACCGGGCT CAGGCTAGCT CTGGCAGCGG AGCCGCTGGA AGAGCGGCGA AGCTCGGCGC 3 00

GTCCCGAAAC AACTGAAGGC CTGGCCCGCC GCCCACCCGC GCAGGATGTG ACTGCAGCCC 3 60

TGCTGCGGTC CCCAGCTCCC CGAGGG CTTG GCTTTCTCCG GGACGCTTGT CACGCCAGCG 420

TGCCCCAGCT TCCTAGGACC TGAGAACTCT GCCTTTTCTC AAGTCCCTGC AACCCAGGAG 4 80

GCCTGCCCGG GTGCTAGTAG GCCATGA 507

(2) INFORMATION FOR SEQ ID NO: 901:

391

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FC17US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 95 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 901:

GAATTCGGCC TTCATGGCCT AGTTTGGATT TTCATATTAG GGATACTCAA CTGGTATTAT 60

TATTCTGGCC CCTGCAAATT TTTCAGTAGG TCCCCTAGTA TGTCATGCCA GGGACTATGN 120

GAGTTCCTGG GAATAG CACT GTAANACATT CTTGAGTGGG TCCTTGACTC CATTGAGTTT 18 0

ATAAT CTCGT AGGAGGAAGG CTATGAAGAA TTCTAATAAA GCAAAGCAAG CAATCACAAC 24 0

AAACCTTCCT CTTTAACTTA TCAAAAATGG AAA CTTTG AA GAGCTGCTCT TTAATAAAT C 300

ATTGGAAAGC ACCAGGACCC AGGTGTTTTG ACTCAGCCTC ATTTCAGACT GAGATCTGAG 36 0

GCCATGATAA CTCATGTGCC TATATATGCT G ATAAT CAC C ATTACCTATA CCATTCTTTA 4 20

CATTCTCTCA TCTACACAAT CATCTTCAAC TCTCTCTCAT CCACTTCAGC GATTGAATTC 4 80

TTTACCGGCC TCGAG 4 95.

(2) INFORMATION FOR SEQ -ID- NO: 902:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 266 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 902:

GAATTCGGCC AAAGAGGCCT AG AATT CCAG ACCTAGCTCA ACCCATGCCT CCTTTCCTTC 6 0

CTTCCCTCCT TCCTTTCTTT CTTTTTCCTT TTCTCCTTCC CTCCCTTCTC CCTTTCTTCC 12 0

TTCTCTCCCT CTTTCTCTTT CTCCCTTCTT CCTGCTCTTC CTTCCTTCCT CCCTCCCTCC 18 0

CCTCCCTTCT TTCCTTTCCT CCCTCCCTTC CATTCTTTCC TCCCCCACCC CCCGTTTCTT 24 0

CTCTTTGGAG AGATGTACAG CTCGAG 266

(2) INFORMATION FOR SEQ ID NO: 903:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 410 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 903:

GAATTCGGCC AAAGAGGCCT AAATGAGAGC TGAGTGAAGT GGATGCCCCT TATAAAAACA 6 0

TCAGATCTCG TGAGAACTTA CTATCACTAG AATAGCATGG GGGAACCACC CCATGATTCA 120

GTTACCTGCC CCCAGGTCTC TGCCACCACA CATGGGGATT ATGGGAACTA CAACTCAAGA 180

TGAGATTTGG GTGGGGACAC AGGCAAATTA TATCAGCTGT TGTGCTCATT AGTTTGTATA 24 0

TCATCCTTGG CTCCTTTAGC ACTATAAGGG CAGGATTGAG TCCTTGCAAC AGAAACCATT 300

CAGCCTGCAA AGCTGAACCT ATTTACTTTC TGACCCTTTA TGGAAAAG TT TACTGATCTC 360

TGGACTAGAC AGTTTTTTAA AAATGACATC TTATGACCGG GATTCTCGAG 410

(2) INFORMATION FOR SEQ ID NO: 904:

392

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 26 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 904:

GAATTCGGCC AAAGAGGCCT AG CCGAGACT CTGTCTCAAA AAAAAGAAAA AAAGCTGCTT 60

TGGGTCTTAT GAGGGAGGGG ACTGGGAATC TAGGTGTTTC AAGCGCCCCA GGCGATTCTT 120

AAGGTCACAC AAGCTTGGGA GACACTTCAT TAAGCAAAAT CTTTTGGCCG TTTTGTTCTG 180

GTTGAGCCTC AGTGTCTATT CATTGAGTGG T CACCAAG AG TTTGGGGTGG ACTGATCATC 24 0

AGCATTTACA GGTTTGGAAA TTGAATTTAG TTTTACTACT CAGAGCTTAT TAGACTTGAG 3 00

CAGATTTAAA CGGAAGGACA CTCGAG 326

(2) INFORMATION FOR SEQ ID NO: 905:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 410 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 905:

GAATTCGGCC AAAGAGGCCT AGGAACTGTT TTGACCCTGA AGGCTATTTA ATCCACTGTC 60

CCCTACAAGG CCTCACAAGT GCTGGGGGAA AAAAAACAGC AATGAGGATG ATCCTGAGTT 120

AATGTGTATG CTCCGCAAGA GAGCTTGCCT ATACCTTGAT TATTTCATAA AATCACATGT 18 0

TAATACATTG CTTTCAGAAT GAAATACTGA CTTGATCTGA TAGGAGAAAA TGGTAATATT 240

TCATAGTTGT TTTCCAAAGA CAAATTTAAA TGTTGTCTGT TATCTCCTTA CTTAGTTTAA 3 00

GAATTTAGTT TTGAACCCCA TTGACTTTGT CATTTGCAAT TTTAAAAATA TTTGGGACTG 36 0

GGCATGGTCG CTCACGCCTG TAATCCCAGC ACTTTGGGAG GCATCTCGAG 410

(2) INFORMATION FOR SEQ ID NO: 90 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 98 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 906:

GAATTCGGCC AAAGAGGCCT ACGCTTCCCG GG TTCAAGCG ATTCTCCTGC CTCAGCCTTT 60

TGAGTGGCTG GGACTACAGG TGGATGCCTC CATGCCTGGC TAATTTT TTG TATTTTAGTG 120

GAGACAGGGT TTCACCGTGT TGCCCGGGCT GGTCTTGAAC TCGTGAGCTC GGGCAATCCA 180

CACTCCTTGG CCTCCCAAAG TGCTAGGATT ACAGGTGTGA GCCACTGCAC CCGGTCGAGG 240

TACAGTTTTG AAGTTCATGC AAATCTCATC ATTTGCTCTT CTGCAACAAA ACATTTTCTT 3 00

TCAACTTATT TTGCCTGTGT GAAGCTCAGT GCTTTAACTC ATATATGGAG TTATCTTCTT 3 60

CCCTCAGACT GGAGACGTTG GTGAAATTGG GGCTAGACTG AAGATGTCTA AGGTGGCTTG 42 0

ATTGACAAAG GTCTCTCCTC ATCCCCAAAA TAAATAACAT TTTTTCATTT ATAATAGTAA 4 80

TACACCAGTC GACTCGAG 4 98

393

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PCT/US98/06956

(2) INFORMATION FOR SEQ ID NO:907:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 481 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 907:

GAATTCGGCC AAAGAGGCCT AAACTGGTGC TGGTTTCACA TCACGACAGC AACGGGATTC 6 0

TTTTGCTTTG AAAATGTTGC AGTCCACCTG TCCAACTTGA TCTTCCGGAC ATTTGACTTG 12 0

TTTCTGGTTA TCCACCATCT CTTTGCCTTT CTTGGGTTTC TTGGCTGCTT GGTCAATCTC 180

CAAGCTGGCC ACTATCTAGC TATGACCACG TTGCTCCTGG AGATGAGCAC GCCCTTTACC 240

TGCGTTTCCT GGATGCTCTT AAAGGCGGGC TGGTCCGAGT C1CTGTTTTG GAAG CTCAAC 3 00

CAGTGGCTGA TGATTCACAT GTTTCACTGC CGCATGGTTC TAACCTACCA CATGTGGTGG 3 60

GTGTGTTTCT GGCACTGGGA CGGCCTGGTC AGCAGCCTGT ATCTGCCTCA TTTGACACTG 420

TTCCTTGTCG GACTGGCTCT GCTTACGCTA AT CATTAATC CATATTGGAC CCAGACTCGA 4 80

G 481

(2) INFORMATION FOR SEQ ID NO: 908:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 764 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 908:

GAATTCGGCC AAAGAGGCCT AGAAACAATG GTTTTCAGAC ACTGAAAGTT CATAGTACAG 60

GACTGTGATC TCTGCGAGAA GGGGGAATAA TGAGGTGAGT CCAG TGATTG CTCAGG CGAA 12 0

TGGCCTGGAG GCAGTTTCTA GGCAGCAAAG CAGGGAGAGG GAAGCCAGAG ACCAGTGGTC 180

CTGCTGTGTT GAGGAGATGG AGATCAGTGT CACCGGAGGC CAAGGTGAGT AAGTGAGAGG 24 0

AGAGGAGGCA GCAGCACACA GACAGAGAGT GCTGTAGATC TGCAGTGGGT CCCCTGGAGT 3 00

CCTTGGTTGA GTGAAGGTGT TAGAAGAAAC TACTTAAGCC AAGAAATGAG TAACTGGAAA 3 60

TTAGTAGAGC AAATAATTTA CAGATCATCT ATGGGGCTGG GAAAAGTTTG TGTTTCCACT 420

AGCCAGAGTA GAAATAACTC ATAATGCATG GGTCATCAGG TGGAGTCCTC CAACAGGTGT 4 80

TGCCTTAGTA CTGAGGTCAA ATTGTCCCTA GACCAAAGGC TTCTTTGGAC TTCCCCTAAC 54 0

AAAG CTTAAA GACAAGCCTT GGAAGGATCA AACTAATTTC AAGAAACTTA ACTGTGAATC 6 00

AGAATAAAAC CCAATAC CAT TTATAGGAAT ATAACAAAAT C CAT CAACAN ACNACATAAC 6 60

ACTCATAATT ACCAACATTC AGTAAAAAAT TACTGGAAAC AGAGAAATAT AAATTATGGC 720

CCATAATTAG GAAAAAAGGG TAATCATTAG AGGTAGAACT CGAG 764

(2) INFORMATION FOR SEQ ID NO: 909;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 157 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY -. linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 909:

394

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GAATTCGGCC AAAGAGGCCT ACTAAGGACT TGTTTCGGAA GGAGCTGACT GGCCAATCAC 6 0

AATTGCGAAG ATGAAGGCTC TGTGGGCCGT GCTGTTGGTC ACATTGCTGA CAGGATGCCT 120
AGCCGAGGGA GAGCCGGAGG TGACAGATCA GCTCGAG 157

(2) INFORMATION FOR SEQ ID NO: 910:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 87 base pairs

IB) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

Ui) SEQUENCE DESCRIPTION: SEQ ID NO: 910:

GAATTCGCGG CCGCGTCGAC AGAATAGACC TGGTTTGTGA ATTATGG CCT GGATTTCACT 6 0

TATACTCTCT CTCCTGGCTC TCAGCTCAGG GGCCATTTCC CAGGCTGTTG TGACTCAGGA 12 0

ATCTG CACT C ACCACATCAC CTGGTGAAAC AGTCACACTC ACTTGTCGCT CAAGTACTGG 180

GGCTGTTACA ACTAGTAACT ATGCCAACTG GGTCCAAGAA AAACCAGATC ATTTATTCAC 240

TGGTCTAATA GGTGGTACCA ACAACCGAGC TCCAGGTGTT CCTGCCAGAT TCTCAGGCTC 300

CCTGATTGGA GACAAGGCTG CCCTCACCAT CACAGGGGCA CAGACTGAGG ATGAGGCAAT 3 60

ATATTTCTGT GCTCTATGGT ACAGCAACCA TTGGGTGTTC GGTGGAGGAA CCAAACTGAC 420

TGTCCTAGGC CAGCCCAAGT CTTCGCCATC AGTCACCCTG TTTCCACCTT CCTCTGAAGA 48 0

GCTCGAG 4 87

(2) INFORMATION FOR SEQ ID NO: 911:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 78 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi> SEQUENCE DESCRIPTION : SEQ ID NO: 911:

GAATTCGCGG CCGCGTCGAC AGTTACTGAG CACACAGGAC CTCACAATGG GATGGAGCTA 60

TATCATCCTC TTTTTGGTAG CAACAGCTAC AGGTGTCCAC TCCCAGGTCC AACTG CAGCA 120

GCCTGGGGCT GAGCTGGTAA AGCCTGGGGC TTCAGTGAAG TTGTCCTGCA AGGCTTCTGG 180

CTACACTTTC ACCAGCTACT GGATGCACTG GGTGAAGCAG AGGCCTGGAC AAGGCCTTGA 240

GTGGATTGGA ATGATTCATC CTAATAGTGG TAGTACTAAC TACAATGAGA AGTTCAAGAG 300

CAAGGCCACA CTGACTGTAG ACAAATCCTC CAGCACAGCC TACATGCAAC TCAGCAGCCT 360

GACATCTGAG GACTCTGCGG TCTATTACTG TGCAAGGGAC AGCTCAGGCT ACGACTATGC 420

TATGGACTAC TGGGGTCAAG GAACCTCAGT CACCGTCTCC TCAGGCAAAA CGCTCGAG 47 8

(2) INFORMATION FOR SEQ ID NO: 912:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 433 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO:912:

395

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PCT/US98/06956

GAATTCGCGG CCGCGTCGAC CCAGGATGCC GCGCAGCAGA GCTCTGATTC TGGGGGTCCT

CGCCCTGACC ACCATGCTCA GCCTCTGTGG AGGTGAAGAC GACATTGAGG CCGACCACGT

AGGCACCTAT GGTATAAGTG TATATCAGTC TCCTGGAGAC ATTGG CCAGT ACACATT TGA

ATTTGATGGT GATGAGTTGT TCTATGTGGA CTTGGATAAG AAGGAGACTG TCTGGATGCT

TCCTGAGTTT GGCCAATTGG CAAGCTTTGA CCCCCAAGGT GGACTGCAAA ACATAG CTGT

AG TAAAACAC AACTTGGGAG TCTTGACTAA GAGGTCAAAT TCCACCCCAG CTACCAATGA
GGCTCCTCAA GCGACTGTGT TCCCCAAGTC CCCTGTGCTG CTGGGTCAGC CCAACACCCT

CATCATGCTC GAG

60
120
180
240
300
360
420
433

(2) INFORMATION FOR SEQ ID NO: 913:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 913:

GAATTCGCGG CCGCGTCGAC GCAAGATGGA TTCACAGGCC CAGGTTCTTA TATTGCTGCT 60
GCTATGGGTA TCTGGTACCT GTGGGGACAT TGTGATGTCA CAGTCTCCAT CCTCCCTGGC 12 0

TGTGTCAGCA GGAGAGAAG 13 9

(2) INFORMATION FOR SEQ ID NO: 914:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH : 166 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 914:

GAATTCGCGG CCGCGTCGAC ATCATGGCTA CCCTGCGTGT CCCACTCCTG GTGGCTCTCG 60
TCCTTCTTGC TGTGGCAATT CAGACCTCTG ATGCAGGTCC CTATGGTGCC AATGTGGAAG 120
ACAG TATCTG CTGCCAGGAC TACATCCGTC ACCCTCTGCC ATCACG 166

(2) INFORMATION FOR SEQ ID NO: 915:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 590 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii.) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID N0:915:

GAATTCGCGG CCGCGTCGAC TTCTTGGGCA GCACAGAAGA CAGAGCCGAT TTTGACCAAG 6 0

CTATGTTCCC TGTGATGGAG ACCTTCGAAA TCAATGATCC AGTGCCCAAG AAGAGAAATG 120

GGGGGACCTT CTGCATGGCA GTCATGGCCA TCCACCTGAT CCTGCTCACG GCAGGTACTG 180

CACTGCTGCT GATTCAAGTT CTCAATCTGC AGGAGCAGCT CCAGATGCTA GAGATGTGCT 240

GTGGCAATGG ATCACTAGCT AT CG AGGACA AGCCCTTCTT CTCGCTGCAG TGGGCACCCA 300

AAACACACCT GGTACCTAGA GCACAGGGGC TGCAAGCCTT GCAGGCCCAG CTCAGCTGGG 36 0

396

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TCCATACCAG CCAGGAGCAA CTCCGTCAGC AGTTCAACAA CCTCACTCAA AATCCAGAGT 4 20

TGTTCCAGAT TAAAGGTGAA CGAGGCTCTC CAGGTCCAAA AGGGGCCCCG GGTGCTCCTG 4 80

GAATCCCCGG GCTGCCTGGG CCAGCTGCTG AGAAGGGAGA AAAGGGGGCT GCAGGTCGTG S4 0

ATGGAACCCC AGGTGTCCAA GGACCCCAGG GCCCACCAGG AAAACTCGAG 590

(2) INFORMATION FOR SEQ ID NO: 916:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 592 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 916:

GAATTCGCGG CCGCGTCGAC GGAAGAGCAA TGAAAACATA TGCTCCTACA TTATTCATGT 6 0

TTCTATGGCT GCAGCTGGAT GGGATGAGCC AAGGTG AG CA GGTGGAGCAG CTTCCTTCCA 120

TCCTGAGAGT C CAGGAGGG A TCCNGTGCCA G CAT CAACTG CACTTATGAG AACAGTGCCT 180

CCAACTACTT CCCTTGGTAT AAGCAAGAAC CTGGAGAGAA TCCTAAGCTC ATCATTGACA 24 0

TTCGTTCAAA TATGGAAAGA AAGCAGACCC AAGGACTCAT CGTTTTACTG GATAAGAAAG 3 00

CCAAACGTTC TCCCTGCACA TCACAGACAC CCAGCCTGGA GACTCAGCCA TGTACTTCTG 360

TGCTGCAAGT GAGAGCACCA ATACAGGCAA AT TAACCTTT GGGGATGGGA CCGTGCTCAC 420

AGTGAAGCCA AACATCCAGA ACCCAGAACC TGCTGTGTAC CAGTTAAAAG ATCCTCGGTC 4 80

TCAGGACAGC ACCCTCTGCC TGTTCACCGA CTTTGACTCC CAAATCAATG TGCCGAAAAC 54 0

CATGGAATCT GGAACGTTCA TCACTGACAA AACTGTGCTG GACAATCTCG AG 592

(2) INFORMATION FOR SEQ ID NO: 917:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 166 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 917:

GAATTCGCGG CCGCGTCGAC GAATGAGGTG CTCTCTTCAG TTCCTGGGGG TGCTTATGTT 6 0

CTGGAT CTCT GGAGTCAGTG GGGATATTGT GATAACCCAG GATGAACTCT CCAATCCTGT 120
CACTTCTGGA GAATCAGTTT CCATCTCCTG CAGGTCTAGT AAGAGC 16 6

(2) INFORMATION FOR SEQ ID NO: 918:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 200 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 918:

GAATTCGCGG CCGCGTCGAC GTCTGAGAGG AACCCTTCTC TGAGGATGGA CACTTCTCAC 60
ACT ACAAAG T CCTGTTTGCT GATTCTTCTT GTGGCCCTAC TGTGTGCAGA AAGAGCTCAG 120
GGACTGGAGT GTTAC CAGTG CTATGGAGTC CCATTTGAGA CTTCTTGCCC ATCAATTACC 180

397

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TGCCCCTACC CTATAGTGAG 2 00

(2) INFORMATION FOR SEQ ID NO: 919:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 231 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 919:

GAATTCGCGG CCGCGTCGAC CCAACCTTCC GGAAGCCTCC CCATCAGCAC CATGAACCCA 60

AGTGCTGCCG TCATTTTCTG CCTCATCCTG CTGGGTCTGA GTGGGACTCA AGGGATCCCT 120

CTCGCAAGGA CGGTCCGCTG C AACTG CATC CATATCGATG ACGGGCCAGT GAGAATGAGG 180

G C CATAGGG A AGCTTGAAAT CATCCCTGCG AGCCTATCCT GCCCACGTGT T 231

(2) INFORMATION FOR SEQ ID NO: 920:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 115 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 920:

GAATTCGCGG CCGCGTCGAC GTTTTGTTAT TGTTACGAAG TAAATGATTC GTATGCTGTA 6 0

CATAGCTGTT ATAGAAGTGG CGATTAGTGT AATTAGTAGG GCTCAGGCTC TCGAG 115

(2) INFORMATION FOR SEQ ID NO: 921:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 213 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 921:

GTTGAATTCT AGAAATCAAA ATTAATTTGA CAAAGGAAAA GCAGATGCCG GAAACTTCTT
CCCAGTCTGT CATACAATTC ACCACTGGCC AGGTGCTGAG AGAAGCATTA GGGAACAGTG
TGGGTTGTGT CAGAGTTGGA CGGCTCCATC CCTTTGGCTT CATTATCTTC CTCCTCATGG
AGATTCTAAA GCAACCCGTC GACGCGGCCG CGA

(2) INFORMATION FOR SEQ ID NO: 922:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 504 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

398

60
120
180
213

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(ii)

MOLECULE TYPE: CDNA

(xi)

SEQUENCE DESCRIPTION:

SEQ ID NO: 922 :

GAATTCGGCC
CCATTCAAAT
GTTGCTTTCA
ACCCACTGGT
ACGCTCTCAG
GTGGCCCAGG
TTCTTTAGAT
TCGGAAAACA
GGGATGCCGA

AAGAGGCCTA CTTAGAAGCC

TCCACATGCT GCATTCAGGG

TCGGCTCCAT AATGACCGTG

ACCAGGTGCG GTGCCTGTTC

GGACATGTCT GCTTATTGCC

TGG AC C AG AC CGGCTCCAAG

ACACGGGCAC AACGCCCTCA

TGTGGAACAC GGGCAGCACC

CCACCAGACT CGAG

AAAGAAGGAG ATTTGCACAG G AT AG AAAT C
CTGGTCCACG GCCTGGCTTT CTGGTTTGAC
TGGCTGTCCA CAGCCCCGAC AGAGCCCCTG
CAGTCACCAC TGTTCGCCAA GGCAGGGGAC
AACAAAAGAC AGAGCTACGA CATCAGTATT
TCCAGTAACC TCCTGGATCT GAAAAACCCC
CCCCCACCCG GCTCCCACTA CACATCTCCC
TACAACCTCA GCAGCGGGAT GGCCGTGGCA

60
120
180
240
300
360
420
480
504

(2) INFORMATION FOR SEQ ID NO: 923:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 119 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:923:

GAATTCGGCC AAAGAGGCCT ACATTCAT C A AGTCATCCAA CTTCTATAGT CAAAGCAGGA 60
TCATGTGG CG AAG CAT ATG C TCCACAAGGG TGGATAGCTT TTTTCATGGA ATTCTCGAG 119

(2) INFORMATION FOR SEQ ID NO: 924:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 706 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 924:

GAATTCGGCC AAAGAGGCCT AAAGAGAGTG GAGGAGGAGG ACAAGATTGA TACTATGAGA 60

GTTGGAGGAC ATAATTCATG GATCATAGCT CCAGAAGTGA AAAGGGAGGA AATGTAGACA 120

GAGGAAGGCA TTAG CCATTG AGAAGAATAG GGACATATTT TCTTTACTCT CTTGTCAGAG 180

GAAGATAGCT GGGGGAGTAT AGACAAGTTG TAAGAATGAA GGAAGGAAGG CAAGAGCAGA 240

CTTGTCGGAT GAATTTTATT TT CTCTATG A AGTTTGAGAA TTAAACTTTA TGCTGAGAAG 3 00

GAGGGCAGGA G AG ACTG TAT ATGGAATGTA AGGTTTGGGA TAACCAATGT AAGTTTTGGG 36 0

AATGAGAAAG CCACCTAGGG ATGAGGAAAA AATATTTAAA ATTTTGTATC CACTGAAAAT 420

TCTTCAACAG TGTAAAATGA AG CATG CTCA ACTGGAAATG GTCATATATC TAAAAGAAAA 480

TGGATTTATT TTGTTATTTT TCTCTATATT TGTAGTATTT TACAGTAAGC ATGTAT TACC 54 0

TTTATAGTGA AAAAGTGTCA TTTTTTTACA TTGGTCAATT TTTTGTTATT AAATTTCATG 600

CTTGTTTTTA ATTGTTTCTT GTGTGTATGA TTGCAATATC AGGTATTTGA TGTGGTGATG 660

TGTGTGATTC AGAAGTCAGA AGACTTAAGT TCCGACACCC CTCGAG 706

(2) INFORMATION FOR SEQ ID NO: 925:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 651 base pairs

(B) TYPE: nucleic acid

399

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(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION:

SEQ ID NO; 925:

GAATTCGGCC AAAGAGGCCT
GCTGATAGCT GGAGTTTCTT
TATGATTCTT CAC AT CATGA
ACCTCTTAAG CCCTATGCCC
CAAAGCAAGT CACAAGG CCA
GTGAGAAGTA GCAAGGTCAC
GTGGCCTTTA TAATAATCTT
TGATAGAAGA TAAGTAG CTT
TATGATGCAG GTTCACTGTG
CAATACTGTG TACCAGTA-C
AGTTTAGGGA AG CAACTTTA

AGGATTCAAA
GTCTTTTTCT
TGGCTTAGGG
AAGAACTCAT
GCCAGATTCA
ATTGCAAAGG
CCACAAATGC
ATTTCAGTAT
CACTGGTATC
AATCCACTGG
TTACTCACAG

TTATTCTGAC AGACCTGTGT GGCAGTTCAG
ACATGGCCTT TCATCTTCCA AGAGTTAGAC
TCCCAAAAAG AAAAGAGTAG AACTTGCAAT
ACAGTGATAC TTCTGCCACC TTGTGTTAGT
AAAGAATGGA AAAATAGACT CAATTTCCTG
AGTCTGGACA TGGGAAGGAG TTACT CATTT
CTGTAATTTG GGCACTGTGC TTAGTACTGG
CTTAATTTTG TTTTATATAT TTGATAATTT
AATCCCAGGG GAGGACTGTA AACACCTTGC
CATGAGTCTG GTGAGACAGA ACACACAATA
AC AGGCAG C A AGGGACTCGA G

60
120
180
240
300
360
420
480
54 0
600
651

(2) INFORMATION FOR SEQ ID NO: 92 6:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 70 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 926:

GAATTCGGCC AAAGAGGCCT AAAAAGATGA AAGGACCAAT CAAAGATTTA ATTAAAGCTA 60

AAGGGAAAGA TTTAGAGACA GAGAATGAAG AAAGAAATTC TAAGTTGGTG GTGGACAAAC 120

CAGAACAGAC AGTGAAGACC TTTCCACTGC CAGCTGTTGG TTTGGAAAGA GCAGCTACTA 180

CAAAGGCAGA T AAA G A CATC AAGAAT CCAA TCCAACCATC CTTCAAAATG TTAAAAAATA 24 0

CTAAACCAAT GACTACTTTC CAAGAAGAAA CCAAGGCTCA GTTTTACGCA TCAGAGAAAA 300

CCCTCCTAAA AGAGAACTTG CCAAAGATTT GCCTAAATCA GGAGAAAGTC GATGTAATCC 360

TTCAGAAGCT GGAGCGTCTT TACTGGTTGG CTCAATAGAA CCTTCTTTGT CAAATCAAGA 420

TAGAAAATAT TCCTCAATTC TACCTAATGA TGTACAAACT ACCTCTGGTG ATCTCAAATT 4 80

GGACAAAATT GATCCCCAAA GACAGGAAAT TCTAGTAAAA TTACTAGATG TGCCTACTGG 54 0

TGATTGTCAT ATTTCTCCAA AGAATGTCAG TGATGGGGTT AAAAGGGTAA GAACATTATT 600

AAGCAATGAG AGAGATTCCA AAGGCAGGGA TCACCTCTCA GGAGTCCCTA CTGATGTTAC 660

AGTTACTGAG ACTCCAGAAA AGAACACAGA ATCCCTCGAG 700

(2) INFORMATION FOR SEQ ID NO: 92? :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 378 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 927:

GAATTCGGCC AAAGAGGCCT AGGGGTGGTG GAGGCGTGGA CCCAACGGTG ACCGTCGGGA 60
TGGAG CAAGG GCAAGGAGAG GCTCTGGCCC AGACACAGCT TGGAAAAGCT CATCTCCCTC 120
TGGGGTTTAA AAACTCAAAG CAAACGG AG C AAGCCTGGCG GCCCTGGGGA TGGGGCAGGG 180

400

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CCTCTACCTC ACTGTGATCT TCGACCTGGC GACACAGGAC AGCCACACAG AAGCACGCCA 24 0

ACACACTTAA AGCTTTGCTC CAACTAAATC ATTTAGTTTC CCTTGAAGAA ATAACTGAAA 3 00

AAAAAAACAA CTGCTGACAT CTATGTCTGT AGCTCGATTT TACAGTCTGC TCTTTGTGAG 3 60

AAAGGAAAAT CACTCGAG 3 78

(2) INFORMATION FOR SEQ ID NO: 928:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 426 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

Ui) SEQUENCE DESCRIPTION: SEQ ID NO: 92 8:

GAATTCGGCC AAAGAGG CCT AATATTTCAC ATTTCTCTTT TCTAAAAGTG TAAATTTTTC 60

ACTTTAAAAT GAAGCAAGAA TTAAATAAAT AGAACAAATA CCATATATCA TCACAGAGTC 120

AATATATTAT GGTCCTGTTC TGACCAAGTG TTGCATTGTA TTTGTGTTAC CAGAACTGCA 180

GGGCTTTCTA TGGCTACATG GTCAGTGCAT GCTCAGACAG CTGTTAAAAT CAAAACCTTC 24 0

ACTGTGCTGG GTCACCTGGT AACTACTGTC TATCTCACAA GTGCATTCTG CTGACATTCA 3 00

AGGGTTAAAC TGGTTTCTAG TAAATACTGT GCTTTAAAGT AGTACATACT GTGAGCTGTG 3 60

TTATTAGAAA CCTGCTTGTC CTTGTGTCTG AAAATAAGGA GGAACACTCT CGCACCAAAT 420

CTCGAG 426

(2) INFORMATION FOR SEQ ID NO: 929:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 929:

GAATTCGGCC AAAGAGG C CT AGGTAAATGT TAGTGGAAAA TTTTATGAGT ATATGCTGAA 6 0

AGGAGAGATT AGTTCACATG AACTCAATAA TGTTCAAGAT AATGAAATGC TTAGAAAGGT 120

TACTTTTGAT CCAGAAGTAT TTTTCAACAT ATTACTTCCT CCTAT CAT AT TTTATG CAGG 180

TTATAGCCTG AAAAGGAGAC ATTTTTTTCG AAATCTTGGG TCTATCCTAG CATACGCTTT 240

TCTTGGAACA GCAAT TTCTT GTTTCGTTAT TGGGTCAATA ATGTATGGCT GTGTAACGCT 30 0

GATGAAGGTA ACGGGACAAC TCGAG 32 5

(2) INFORMATION FOR SEQ ID NO: 930:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 06 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 930:

GAATTCGGCC AAAGAGGCCT ATGGACACCC TGTGCCCCAA GCCGATGGCC CCACCCAGCA 60
GCATCAGCAC AGNTGCCCCC CTTCTCCGCA GAG CAGG CTC TCCTTTACGG GACTCTCCTC 120

401

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TTCCCTCCCA CCTGATGCGC ATCAGCAGCC ACGGGCCTGG CCCTTGAATC TTGTCTAACT 18 0

GCACTCGCTG CCTGGTGGCC TCATCCCACC CCAAGACCAC TGCACTGATG GCTCCAACCC 24 0

CAACTTCTCC CTGCACTCAG CTTATGAATA CGACGGCCCT CATTGCATCC ATGCAGAGAC 30 0

CTCAGAGGCA GCTCAGCTCA GTGCTCAGCG TGGCACTCGG GG CTTCAC AC TTCCCCCCGT 36 0

GTCCTGTCTG AGAAAACTGT GACAC CATCA AC CCAACTAA CTCGAG 406

(2) INFORMATION FOR SEQ ID NO: 931:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 6 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 931:

GAATTCGGCC TCATGGCCTA CCAGACTGTA AACATTCCAG GTCCTGAAAA AGTGTTGGAC 6 0

CAGTCTCCTA CTGTTATGTT CTCCAGTTTT AAAAATGTAA AAT CAGTTGA AACACTCGAT 120

CAGAAGGCAG ATGAAGTCCT TGACTGTCAG AGTAACCAAA ACAGACCAGA TGAATGCAAA 18 0

AGTGAAGGTC AGTCAGCCAA GGAGATGCTA AGTAG TG AC C AGAGAGAGAC TGTCAC CGG A 24 0

CTCGAG 24 6

(2) INFORMATION FOR SEQ ID NO: 932:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 278 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 932:

GAATTCGGCC TTCATGGCCT ACTCCATTGT CACGCCAATT TCCCCTAGTC CAAGTTTTTT 6 0

CTTTGCTGAT TCCTTTGTCC ATGTGTGCTT TGAGCCTCTC TCATCTTGTC TTTCCTCCTT 12 0

TCCTAGGAGC AG CTCCTGAA GCAGCAGCAG CAG CACCAG T GGCAG CAGCA TCAACAGGGC 190

TCTGCCCCTC CTACCCCAGT GCCCCCATCA CCACCACAGC CTGTGACCCT GGGGGCTGTG 24 0

CCAGCTCCAC AGGCTCCACC CCCGCCCCAC AACTCGAG 27 8

(2) INFORMATION FOR SEQ ID NO: 933:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 421 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 933:

GAATTCGGCC TTCATGGCCT ACGAGTGCGA CCAGC CAG AT GAGCGCCCGG TCCTGGTGAA 60

GAGCATTCAC TACCTCTACT TCTCCATGAT CCTGTCCACG GTCACCCTCA TCACTGTCTC 12 0

CACCGTGAGC TGGTTCACAG AGCCACCCTC CAAGGAGATG GTCAGCCACC TGACCTGGTT 180

TACTCGTCAC GACCCCGTGG TCCAGAAGGA ACAAGCACCA CCAGCAGCTC CCTTGTCTCT 24 0

TACCCTCTCT CAGAACGGGA TGCCAGAGGC CAGCAGCAGC AGCAGCGTCC AGTTCGAGAT 3 00

402

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GGTTCAAGAA AACACGTCTA AAACCCACAG CTGTGACATG ACCCCAAAGC AGTCCAAAGT
GGTGAAGGCC ATCCTGTGGC TCTGTGGAAT ACAGGAGAAG GGCAAGGAAG AGCTCCCGGC
C

360
420
421

(2) INFORMATION FOR SEQ ID NO: 93 4:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 44 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:934:

GAATTCGGCC AAAGAGGCCT AAAATAGCAA AGATGGAACA TGGACCTAAA G CAGTG ACTA 60

TTGCAAATTC TCCATCAAAG CCTTCAGAAA AGGATTCTGT AGTTTCCCTT GAGTCCCAGA 120

AGACACCTGC TGACCCAAAA CTGAAAACTC TAAGTCAAAC CAAAAAAAAC AAAGGATCTG 180

ATAGCTCACT CTCTGGTAAC AGTGATGGCG GAGAAGAATT TTGTGAAGAG GAGAAGGAAT 24 0

ATTTTGATGA TAGCACAGAA GAAAGGTTTT ACAAGCAGTC TTCCATGTCT GAAGATAGTG 300

ATAGCGGTGA CGACTTCTTC ATTGGGAAAG TCAGACGGAC ACGAAAGAAG GAAAGTAGTT 360

GTCATTCTTC AGTTAAGGAA CAAAAACCAC TAGAAAAAGT GTTTCTTAAA GAAGATACAG 4 20

GTGAAACTCA TGGGGATACA ACTCTCGAG 44 9

(2) INFORMATION FOR SEQ ID NO: 93 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 421 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 935:

GAATTCGGCC AAAGAGGCCT AAAAATAGTG ATTTTTTGAC TATCTATAGA TATTAGTTGG 6 0

CATTCTACTG TAAGGAAAAC TTTCTTTTCT CCTGTACTTA TTCATCGTCC CCCAGGAATC 12 0

AGTCATTTTT C CAAGG AG AC CTAGTTCCTT TTTGTGAGGA GTTGTTTTGA GTTCATTTTG 18 0

AAGTTCATTT GAAGTTTTGA GTTCATTTTA CTATAATCTG CCTAGGTGTG ATTTTCTTTT 24 0

TATTTATTCT GCTTAGGATT TGCAGAGATT TTTTTGAACC TGTGGCTTGA TGTCCATCAC 300

TTTTGGAAAT TTCTCAGCCA GCATAGTATC TG CAGACTGT GTGTCTGTTC CATTTTCTCT 36 0

CTTTTCTCCT TGTAGGACTT CATTCACAAG GATGTTAGAA CTTTTTACCA TGGCTCTCGA 420

G 421

(2) INFORMATION FOR SEQ ID NO:936:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 64 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 93 6:

GAATTCGGCC AAAGAGGCCT ACAGGTCTAC TG GTAATGAT TTCCTTTACC TTC TAATTAT 6 0

403

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ATAGAAATGT CATAATTTCT CCTTTATTCT TGAATGATAG TTTTGTGGGA TATAGACTTG 12 0

CTGGATATAG AATTACTGGA TATAGAATTG C C AG AT AT AA AATTCTTGGT TCAAAGTTTT 180

TTTTCTTTGA GGACTTTGAA TGT CATC CCA CTGTCTTCTG GCCTCCATAG TTTCTCATAA 24 0

TAAATCAGCT GTTAATCTTC ATTAAGTTTC CTCTGTACAC GAAGAGTCAC TTGTCTCTTG 300

CTGCTTTCAA ATTTTTCTCA TTTGCTTTGG GTTTTCACAC TTTAATTATA TGCCTTTCTA 3 60

TGTGGATCTC TTTGAGTTTA TCCTGCTTGG AGTTCATTGA GCTTTTTGCA TCTGTATATT 42 0

AATTTCTTTC ATCAGATTTG GAGATGTTTT TGGCATTTAT TTCCTCAAAG TTCTTTCTGC 480

TTCTTTCTCT CCTTCTCCTT CTGGGTCACC AC AATG CATA TGTTGGTCTA CTTGATGATG 54 0

TCTCACAGGT TCCTTAGACT CTGTTTACTT TTCTTCATAT TTTTTTCTTT CTGTTTCTTA 60 0

AATTTGGATA ATTTTGGTTG TCTTATATTC AAGTTTGCTG ATCTCGAG 64 8

(2) INFORMATION FOR SEQ ID NO: 93 7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 160 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 937:

GAATTCGGCC AAAGAGGCCT AGAGGATGGG AAGCTTGGGG AGAGAAGATA CTGAAATGCT 6 0

AGAAACTGAG CCAGTAGAGG ATGGGAAGCT TGGGGAGAGA GGACATGAGG AAGGATTTCT 120
GAACAACAGT GGGGAGTTCC TCTTTAACAA GCAGCTCGAG 160

<2) INFORMATION FOR SEQ ID NO: 93 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 99 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi> SEQUENCE DESCRIPTION: SEQ ID NO: 93 8:

GAATTCGGCC AAAGAGGCCT AGAAAAACT C AGGAAAGAAA TTGCAGACTT CGAACAACAG 60

AAAGCAAAAG AATTAGCTCG AATAGAAGAG TTTAAAAAGG AGGAGATGAG GAAGCTACAA 12 0

AAGGAACGTA AAGTTTTTGA AAAGTATACT ACAGCTGCAA GAACTTTTCC AGATAAAAAG 180

GAACGTGAAG AAATACAGAC TTTAAAACAG CAAAT AG CAG ATTTACGGGA AGATTTGAAA 24 0

AGAAAGGAGA CCAAATGGTC AAGTACACAC AGCCGTCTCA GAAG CCAG AT ACAAATGTTA 300

GTCAGAGAGA ACACAGACCT CCGGGAAGAA ATAAAAGTGA TGGAAAGATT CCGACTGGAT 36 0

GCCTGGAAGA GAGCAGAAGC CATAGAGAGC AGCCTCGAG 399

(2) INFORMATION FOR SEQ ID NO: 93 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 519 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 93 9:

404

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PCT/US98/06956

GAATTCGGGC
GGCGAGAAGG
AGCTGTAGTC
AAGTATATTT
TTGAACCAGC
TGGGCTGCAT
GTAGAACAAC
CCAAACAATC
TGGGGAATGC

AAAGAGG CTA
GTGTTCCCGA
TGAATCAACC
TAAAAGAAGG
AACAATGGAT
TGGCCCAAGC
CACCAGGAAT
ATGGGAATTT
ATCAGCAACC

GAAGCATCGA
ACTAGAGTGG
TAAGTTTTAA
GATGTGGGAT
GCAGTCATTC
TTGGATTGCC
GATGCCAAAT
C CAAGGGG AT
CCCACACCCC

AAG CGTTGGA
GG CAT AC ATA
ACAGAAGGTG
CAAGGAGGAC
CAGCACCAAC
CAAAGAGAAG
GGACAAGATA
TCAAACTTCA
CCCCTCGAG

GAGGTGTTAC
ATCTTGCTGC
AACCTCTGAG
AGCCTTGGCA
AGGATCCAAG
CTTCAGGACA
TGTCTACAAT
A C AG AATGTG

CGGTAACGGC
TATGCTTCGA
ATAGAAAATC
GCAGTGGCCC
CCAGATTGAT
GCAAAG CATG
GGAATCTGGT
G CAAC GAG AA

(2) INFORMATION FOR SEQ ID NO: 94 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94 0:

60
120
180
240
300
360
420
480
519

GAATTCGGCC AAAGAGGCCT AAGAAATTAT ACCATTTTAT GGAATGTCAA GCTACATCAC
CCGAGAAGAC CAGTACAGCA AGCCTCCGCA CAAAAAACTG AAAGACCGCC. AGATCGATCG
CCAGAACCGC CTCAACAGCC CTCCTTCTTC TATCTACAAA AGCAGCTGCA CAACAGTATA
CAATGGCTAT GGGAAGGGCC ATAGTGGTGG AAGTGG CGG A GGCGGCAGCG GTAGTGGTCC
CGG AATTAAG AAAACAGAAG CGCTCGAG

(2) INFORMATION FOR SEQ ID NO: 941:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 535 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 941:

60
120
180
240
268

GAATTCGGCC AAAGAGGCCT AAGCCTCGCC TTACACTTAA GTGCACCCGA TCCTGCCTCT 60

GGCATCTCAC AAACGTCACT CCCTGGAACA AATTTGTGAA GGCCTCCAGA CCACAGTGTC 120

CTCATCTGTA AAATGGGGGT AGTAGTAATC CTTGCCTCAT AAAGTTCTTG GCAAGGATTA 180

GATGAGCGAG CATGTGAGTT TGGCCTCCGT TTAAACACTC CATAAAGTTT CCTTTTAGGA 240

TAACAGCAGG CCGTTTTAGA ACCTTCCAGA GGTTACTTAT TCAGATATCC TTAGGTGACG 3 00

ATTGGGAAGC TGCCGTTTCT TGAGAGCCTC CTGGGTGACA GATGGAGAGT GGCCCTGGCG 3 60

TGACCCTTGA CCCTATCCTT GAGGCTTTCC TGCCCGTCTC CTGCCTCGAA TGTGCTCCGC 4 20

AGCACATGGA TCAGGATGGG GAAGGGGCTG TGTCACTGGA TACCTTCGGC CCCTGCCCAC 4 80

GTCTAGGGCC TGTGAAAACG AGGAGGGACA GCAAAGAAAT GGGGAAAGGC TCGAG 53 5

(2) INFORMATION FOR SEQ ID NO: 942:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 316 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

405

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PCT/US98/D6956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94 2:

GAATTCGGCC AAAGAGGCCT AAAATTGTTA ATTCTAGTCA CCCTGCAGTG CTATAGAACA 60

CTGGAACTTA TTCCTCCTAT ATCACCGTAT TTTTGTATCT ATTAACAAAC CTCTCCATAT 120

CCTCCCTCCC TCCTACCCTT CCCAACCTTT GGTAATCACT ATTCTCCTCT CTACTTCTAT 18 0

GAGATCAATG TCTTTATTTA CTCGAAGTAC TCTTAAAAGT TTAGGACTTA AGTATTTGAA 24 0

GAAATTCACT TGCTTTTTGT TTTTATTCTA CTCAATACTT TTTAATATAA AGATTTACAG 30 0

TCCCCCCTTA CTCGAG 316

(2) INFORMATION FOR SEQ ID NO: 94 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 363 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:943;

GAATTCGGCC AAAGAGGCCT ACAAACTCAA GATGCCCGAG TGGATTGGAG GCGAGAGCGA 6 0

GCTCAGGAAG TTTCTAAAAC ATCATTTGCG AGGAAAGAAC TGTGAACTCC TGCTGGTGGT 120

ACCAGAAGAG GTAGAGGCTC ATCAGAGTTG GAGGACCGAT GTGTAACAGT TCTGCCCAAC 18 0

CTCCCTCTCG CCTCAGCCCC TTCAGTCCTC TGTGACGTGC TGTGGCCTCT ACAGTGGGTC 24 0

TGCCCTTGCC ACTTCCCCAA ACATCTCATC AAGTTTTTCC CCTTCAGATC TGACAGTGCA 30 0

ATAGGACAGA CGTGTGGACT GTTATAAGAA CTACTCAGTG TTTTGTTCCT GGGCAAACTC 3 60

GAG 363

(2) INFORMATION FOR SEQ ID NO: 944:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION.: SEQ ID NO: 944:

GAATTCGGCC AAAGAGGCCT ACTCTGACAG TGTTTCTGAC CTTTAGCATT TCTTTTTGAT 6 0

TCTTTCTTAG AATTCTCATC TTCTG CTTAT ATACCTGTCT ATTCTTGCAT GCTGTCTACG 120

TTTCCCATGA GAGTCCTTAG CACATTAATC ATGGTTGTTT TACATTCACA GTCTGGTAAT 180

TCCAGCATCC CTGCCACATC TGAATCTAGT TCTGATGCTT GCCCTGTCTC TTCAAACTCT 24 0

GTTTTTTTGC CTTATAATCT TTTGTTGAAA GCCGAACATG ATTCCTGTAC TGGCTCTTCT 300

GGAGGCTTCT GCCCTGTTCT CGAG 3 24

(2 J INFORMATION FOR SEQ ID NO : 94 5 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 712 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 945:

406

WO 98/45437

PCT/US98/06956

GAATTCGGCC
GTCAGAATGG
TCGTCTGGCT
TGACAGCGGT
AGTGTTTCAG
AGCAAAATTC
CTCAGATCAG
GTATCGTAGA
GCAGGGTCCA
TTTTCACTAA
CACTTATTTT
TATGAAGTGG

AAAGAGGCCT
GAGAGGAAGG
AACACCCATG
TTCCTGGAGT
TTGATTGGGT
CCGGGGCACT
GAGTCCTGAC
CACCGCCTGT
CTGCTGTGTG
TAACATAACT
TTAGGCTCGT
ATATTGCTTG

ACAGATGACT
GAGGTGTTGG
TGGCAAATAG
GCTGTCTTGA
GTGTCTGTCA
TCTGTCCATT
TACCCTGCCT
TTGTGAACAG
GAATGGCCTT
CTCCTTTTGA
TCTTCAGATT
ACCGTAGGGA

TCATTTCTCT
GATAAGTTTC
GTTTCATCAT
GAACGATTCT
TGGAGAAGGA
ATCTCAATAC
CTGACCACTC
ACACCCTGCT
CGGTCATTTC
TTGAAAGTGT
TGCCCCATAT
GCTTGTCCAT

TGGATTCCAC
AGTTCCACTG
TTGTTTCAGC
GAGGAGGCTC
AGTAAGGAGT
CTGGGGTTGA
GAACTGAGTG
TCTTGATAAC
TGCCCAGAGC
TAAAATGTTC
CCTAAGCAAA
ACTGTACTCG

TTTCTCACGT
TTTGTACTTC
TTAGATTTGT
AG CAAG AAAG
GGGCAGTGCT
CATTTCCTGT
CTGCTTAGCT
ACAAAGGCCA
ATAGAGGTCA
CTCCTAAAAG
ATGCCTTCAA
AG

(2) INFORMATION FOR SEQ ID NO: 946:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH; 305 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94 6:

GAATTCGGCC
AAAGG CAT CC
TGGAGTGTTT
GGACCTAGTG
GAACCAAGGA
TCGAG

TTCATGGCCT
CAAGAGGAGA
TGAGGAACCA
TTGTTTGAAA
AGAAAAAGCA

AGTCTTGAAG
CAGTAACGTG
CAAGTAGCCT
AAAGAGAGTG
GAGGACAGCT

GATAAGACTT
TGTATAAATG
TCTCTGAGTA
ATCAATGGAA
GGAATGAATC

GCCCAAGTGG
AACGAAGGCG
AGAGCATAGG
GATGAGATAT
AAACCGAAGA

ATAAGGGGCG
TGAAATAGGA
TTTGTGAGGA
CAAGACAGGA
AC CAGGATCC

(2) INFORMATION FOR SEQ ID NO: 947:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 21 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 947 :

GGGTTTTGTT
TGTACAACAG
CTTTAACTTG
CTTGAGTGTA
CCAGCCATTT
ATACACCCAC

AATGGAAAGT
TATTCTAGGC
TAACGTAGCT
GTACAGTTAA
TGTTGTACTT
CATAACTCGA

TTAAGTAAAT
CGCCAACAAA
TCATTCTCAA
AATTT CAAAC
TGGTAAAGGA
G

TATATTGTAA
AGTGTGACAG
AG CTGACTCC
AGCTCCTTGA
CCTCTTCCCC

TAAAAAGGTA
ACACACTAAA

CACTGCTTTT
TTCCTCCCCT

GATAAACCAT
AGCCCTCCAA
TTTTCCTTTT
CATGTTCAAA
ACACATACAG

(2) INFORMATION FOR SEQ ID NO: 948:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 312 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

60
120
180
240
300
360
420
480
540
600
660
712

60
120
180
240
300
305

60
120
180
240
300
321

407

lill

WO 98/45437

PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94 8:

GAATT CGGCC
TCACTCAATC
AAGAATATTA
ATACAATAAT
TTGACAGAAC
CAATATCTCG

TTCATGGCCT
CAAAATAAGG
CTAGAAATGA
TTGAGTGCAT
CCAAAAGGCA
AG

AC AAAAGG C A
CAGAAGAAGT
CTATGTTTTA
ATGAACTTAA
ACAAACAAGA

ACAAACAAGA
GGAAAAGGGA
TAATGCAAAA
AAGAGAATTT
TTAACATGGA

TTAACATGGA
GATGAAGATC
TAGTTCAGTA
CAAAATATAT
AT TATAAAAA

ATTATAAAAA
AGATGGAACA
CAGGAGAAAG
GAAGCAAAAA
TCACTCAATC

60
120
180
240
300
312

(2) INFORMATION FOR SEQ ID NO: 949:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 291 base pairs

(B ) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 94 9:

GAATTCGGCC TTCATGGCCT ATAGGCCATG AAGGCCGGGA GCCTCAAGAA AAATTAGCAG 6 0

AGGAAAATAA TAGGTAGTTA CTATTTAGGG TAAACTAAAC TGTTCTAAGG AATAGAAAAT 120

AAAAATTCCA TGTCTTCAAA AATAATTCTT CCCTCTCAAT CTCTCTGAAT ATCTCATAAG 180

AG TATTCAGG CCACAGAAAT AACTACCATT TAGCCACTCA GAGGCTTATA GTAGTTCTAC 240

TAACTTTAAC ATTTGGCAAC CAAAATTACT CTAAGAATCA TCACCCTCGA G 291

(2) INFORMATION FOR SEQ ID NO: 950:

<i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 24 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 950:

GAATTCGGCC TTCATGGCCT AGATGGG CAT TCTGTTTATC TTACT AG TAG TACGCAGGGT 60

ATGTTGAAAT CTCCAACTGT GATGGTGGAC CTGTCAACTT CTCCCTGTGG TTTTATCAGT 120

TTTTCCTGGG TATTTTGAGG CTATTCTGAT AGGTACATAA AATACAAAAA TTGCTATATC 180

CTCCTAATTA ACACTTATTA TCAAATTGTT ACTAATGCTT TCTGTTCCTA GGCCATGAAG 24 0

(2) INFORMATION FOR SEQ ID NO: 951:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 951:

408

WO 98/45437

PCTWS98/06956

GAATTCGGCC TTCATGGGCT AGATCTGAGC TCACTG CAAC CTCTGCCTCC AGGGTGCAAG 6 0

CCATTCTCCT GCCTCAGCTT CCCAAGTAGC TGAGACTACA GGCGTGTGCC ACCACGTTGG 12 0

CTAATTTTTG TATTTTTAGT AGCTTTTTTT TTTAAACCCT GAGTGTCAGG TGTGAGGTAG 180

TAGAAGAAAG GTAGTGTTGT TGACAGCTTG TGAGTACTTA ACTAATTCTT GTTGCATTCA 24 0

CTATAATATG GTAGTTGTGT ATACATTTAT AGGCAATTAG GAATAGGGAA CAGAATCAGC 3 00

AGATACTAAC GGAGT TAGAG ATGTTTGCTG AAGTCATGGA AAGCCATCAT TACTTTTTTC 3 60

TTCCTTCCTC ATAAGGCCTT AGTGGGTGTG GCGTTCAGCT CGAG 4 04

(2) INFORMATION FOR SEQ ID NO : 952;

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3B2 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 952:

GAATTGGCCT TCATGGCCTA GAAAAATCAT GTGGGAAAAC CACTGCTGAA AATGGATTTA 6 0

AATTCAGAAC AGG CGGAACA ACTGGAAAGA ATCAATGATG CTCTTTCCTG TGAATATGAG 12 0

TGCCGCCGAC GAATGTTAAT GAAACGATTA GATGTGACTG TACAGTCCTT TGGATGGTCT 180

GATAGAGCAA AGGTAAAAAC AGATGATATA GCAAGAATTT ATCAGCCTAA GCGTTATGCT 24 0

TTGTCACCCA AGACAACGAT TACAATGGCA CATCTACTTG CTGCTCGTGA AGATCTATCC 3 00

AAGATCATTA GGACAAGTAG TGGCACCAGC CGGGAGAAGA CCGCATGTGC CATTAATAAG 3 60

GTGCTGATGG GAAGGGCTCG AG 3 82

(2) INFORMATION FOR SEQ ID NO; 953:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 8 base pairs

(B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 953:

GAATTCGGCC TTCATGGCCT AGTCCCTCTT CCACTGCATT TCGGCTTCAT ACATG CAC AT 6 0

GATGTCCTCC TCCTTGCACT CAGTGATGTC TGGCACGCGG CGGTACTGCC GGTGGTAGTA 120

GTAATACCTG TTCTTTGCGT GCTGCCGCTC TATAAATTCT CTCACGAGGG TCACGGGTCG 180

GTCCACGATG AGGTCGAACG CTTT CAT CAT GTAGACGATG GGATTGGGCT GCACCGGCGT 24 0

GCGGCGCGGG GGCTCAGGCT CGCTCGAG 268

(2) INFORMATION FOR SEQ ID NO: 954:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:954:

GAATTCGGCT TCATGGCCTA AAGATTCTGC TCTTTATACA CAGAACTTTG TATAGAGTTC 6 0

409

nil Hi ill IK

WO 98/45437

PCT7US98/06956

TGGAATGAGG AAGTGTGAGG AGGGAATCAG TGCCTCTCGG AAGTCGTTTT AATTAGAATG
TGATTTTTTT TTCTTAAACG TGTCTTCATT GGCTCCCAGA TTTGCCGTAG AAACCAAGCA
AACTGGGTGC TAAAACAGAA AGGCCCATAG ATTGTACTTT TTGAGCTGTT TGAATTTGTA
T AC CATATG C ACAACTCGAG

(2) INFORMATION FOR SEQ ID NO: 955:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 129 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 955:

GAATTCGGCC TTCATGGCCT AATCCGAGTG TTTCGCGCAC GTCCTAAGCT GACAGTCCCT
CTGGACAGAG TCCCTGGAGT GGAGTCACTG CTCCTTGTCT TTTTTTCATA ACATACACTC
ACCCGTATG

(2) INFORMATION FOR SEQ ID NO: 956:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO : 956 :

120
180
240
260

60
120
129

GGCTAAACAT
GATCATAGAC
CAATGAGAGT
CCCCACTTAA
G CCTTTGAG A
GAAAGATCTA
ATAAGACAGA

GGAAATGAAA
AGTATAAAGC
ATCAAAATCT
AAAGCATAGA
GACCCATCTT
TCATGCAAAA
TTTTAAACCA

GACTGATACT
AATTAGACAA
TACATGTCAA
GTGGCAAACT
GCATGTAGTG
GGAAAACAAA
ACAACTAT C A

TGCTACCACA
TGAAGTCTAC
TACTAACCAT
GGATAAAGAG
ACACCCACAA
AAAGAGCAAG
AGAAGAACCT

AAAANANACT
AAAACAACCA
GAATATAAAT
ATAAGACCCA
GCTGAAAGTA
TATCACTATT
CGAG

TAAGCACATA
GTTAACAACA
GATCTAAGCC
ACTGTCTGCT
ATGAGATGGA
CTTATATCAG

60
120
180
240
300
360
404

(2) INFORMATION FOR SEQ ID NO: 957;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 83 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 957:

GAATTCGGCC TTCATGGCCT AGACTCTCTT TATACAATTC ATCAAGGTTA AACAAAACAT 60

AAAATTCCCT TAAAAATAGG GTAATAAAAT AGATGAAATT TGTATCACTC AATTTGGTGA 120

TACTAGTAAA AACTATAGTT CATATTTATA TACAAATAAT ACAGTCTGTA AAAACAGTCT 180

TAGAATTTAA ATAAGCTATC TAAACGTGTT AAAATTTTAA ATCAGGACCT GATTTGTTTT 24 0

GCTTTCCATT AAATGTCACA TTGAATTCTA GACCTGCCTC GAG 283

410

WO 98/45437

PCTYUS98/06956

(2) INFORMATION FOR SEQ ID NO: 95 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 09 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 958:

CTCGAGGACC TGGTCGTGAC CAACTATAAG ATGGGGGGGC GACATTGCCA ATGGGGTACT 60

TCGGTCCTTG GTGGACGCAT CTAGCTCAGG TGTGTCAGTA CTGAGCCTGT GTGAGAAAGG 120

TGATGCCGTG ATTATG CAAG AAACAGGGAA AATCTTCAAG AAAGAAAAAG AGATGAAGAA 180

ACGTATTGCT TTTCCCACCA GCATTTTGGT AAATAACTGT GTATGTCACT TCTCCCCTTT 24 0

GAAGAGAGAC CAGGATTATA TTCTCAAGGA AGGTGACTTG GTAAAAATTA GGCCTCTTTG 3 00

GCCGAATTC 309

(2) INFORMATION FOR SEQ ID NO: 959 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 959:

GAATTCGGCC AAAGAGGCCT AGATTGAATT CTAGACCTGC CTCGGACTAC TGCAAGTGCT 60
TAAAGGCATT ATTTCATAGA CCTTACAACT ACCCATATAA CATTATTATC TTCATTTTAC 120
AAATGAGGAT AATAATGTTA TATCTCGAG 149

(2) INFORMATION FOR SEQ ID NO: 960:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 455 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:960:.

GAATTCGGCC AAAGAGGCCT ACACCGTAAT ACTATAATAC TATATAATCT GTTTGTTAAT 6 0

TTTCTGAGAA TAATAACTCA ATGGAGTAAC TCTTTAATAG GCATCTTTTC CTTATAAAAA 120

ATATTGTAGA TTGGCTCTCT GCAAGCTAAT TTCTTTTATA TGGTTAATAT TTTAGTGTAC 180

ATTAAGAGCT TAGAGTTCTT TTTGTAATCA AGCTTGCTAC AGAAG CTGTG CTTTATTTAT 24 0

TTCATAGTAA TTTCCTCTAG TGGGTCATTG TATAAACCCT GATCATTTTT GTATGTCTAT 3 00

TCCTTTTCTT GCGAAGTGGG CAGCTTGTTT AG CCATGGTG TTTTGGCTTC AATAGTGAGG 3 60

TCTCTATTTG GGAATCTCTG AATTTCACAG GAATGAGTAG AACTATATTT AACAATGAAA 420

AAAATAGTAT TAGATTTTAG GGCAGCTGGC TCGAG 455

(2) INFORMATION FOR SEQ ID NO: 961:

(i) SEQUENCE CHARACTERISTICS:

411

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PCT/US98/06956

(A) LENGTH: 207 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 961:

G AATTCGG CC AAAGAGGCCT ACCCTGTCTT TATGCTCCAA TGCTTCTTTC TCCAGATATG 60

AAAGGAGATG CTCTCTATCA AATGGCCCTG TGGTGGACTT TGATGTCTGG TTCTTCTGCC 120

GGAACCCTGC TGGCTTTTTG CTGTAGCTCC ACATTCCTGT GCATTGAGGG GTTAACATTA 180

GGCTGGGAAG ATGACAAAAC TCTCGAG 207

(2) INFORMATION FOR SEQ ID NO: 962:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 247 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 962 :

GAATTCGGCC AAAGAGGCCT ACTGTAGTAT TTAAATATCT GT TACAGGTT TCCAAGGTGG 60

ACTTGAACAG ATGG CCTTAT ATTACCAAAA CTTTTATATT CTAGTTGTTT TTG TACTTTT 120

TTTGCATACA AGCCGAACGT TTGTGCTTCC CGTGCATGCA GTCAAAGACT CAGCACAGGT 180

TTTAGAGGAA ATAGTCAAAC ATGAACTAGG AAGCCAGGTG AGTCTCCTTT CTCCAGTGGA 24 0

TCTCGAG 24 7

(2) INFORMATION FOR SEQ ID NO: 963:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 472 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 963:

GAATTCGGCC AAAGAGGCCT ACAAGAACAT GAAACATCTG TGGTTCTTCC TTCTCCTGGT 60

GGCAGCTCCC AGATGGGTCC TGTCCCAGGT GCAGCTGCAG GAGTCGGGCC CAGGACTGGT 120

GAAGCCTTCG GAGACCCTGT CCCTCACCTG CGCTGTCTCT GGTGGCTCCA TGAATAGTCA 180

CTACTGGAGC TGGGTCCGGC AGCCCCCAGG GAAGGGACTG GAGTGGATTG GATATATCTC 24 0

TGACAGGGGG AGCACCAACT ACAACCCCTC CCT CAGGAGT CAACTCACCA TATCACTAGA 3 00

AACGTCCAAG AACCAGTTCT CCCTGAATTT GTTCTCCGTG ACCGCTGCGG ACACCGCCGT 3 60

ATATTACTGT TCTCGTGGGA CATCCCCCCC CCCCTCCTAC TACTACTCCA TGGACGTCTG 420

GGGCAAGGGG ACCACGGTCA CCGTCTCCTC AGGGAGTGCA TCCACCCTCG AG 472

(2) INFORMATION FOR SEQ ID NO: 964:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 303 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

412

Ill

WO 98/45437

PCT/US98/06956

(D) TOPOLOGY: linear
(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 964:

GCTCGGCTCG
AGGTAGCTGG
GAGACGGGGT
TGCCTCGGCC
TTT CAAATAG
GAG

CTGCAACCTC
GACTACTGGC
TTCACCATGT
TCCCAAAGTG
AAAATCTGAA

TGCCTCCCAG
GTGCGCGACC
TGGCCAGGAT
CTGGGATTAC
GCTAAAATCA

GTTCGAGCGA
ACGCCCAGCT
GGTCTCAATC
AGGCTTGAGC
CCCCTAAAGG

TCTTCCTGCC
AATTTTTTGT
TCT TGACCGC
CACCGCATCC
ACAAATAACA

TCGGTCTCCC
ATTTTTAGTG
GTGATCTGCC
AGCCAACATT
GGACTATCTC

(2) INFORMATION FOR SEQ ID NO: 965:

(i) SEQUENCE CHARACTERISTICS :

<A) LENGTH: 281 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 965:

60
120
180
240
300
303

GAATTCGGCC TTCATGGCCT AC TAG ATT AT GGATTTTTTT ATTTCAATGG AAGTGAAGTT 60

CAAAGATGCC AGAGTGGTAC AGTTCGAACA AACTGCTTGG ATTGTCTTGA TAGAACAAAT 120

AGTGTGCAGG CATTTCTTGG CTTAGAGATG CT AG CTAAAC AGTTGGAAGC TCTTGGTTTA 180

GCTGAAAAGC CTCAGTTGGT GACTCGCTTT CAAGAAGTTT TTCGGTCAAT GTGGTCCGTG 24 0

AATGGTGATT CAATCAGTAA GATATATGCA GGAAACTCGA G 281

(2) INFORMATION FOR SEQ ID NO t 966 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 454 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 966:

GAATTCGGCC TTCATGGCCT AGACGTGATG TGTTGAGAGA AG AATG TTCT AGGCAGAGGC 60

AACAGCAGAT GCAAAGGTCT GAAGGGGAGA CAGACCGAGC TAGAAAAGCA TGGCACATCA 120

GTGATCTAAG TTCGTGTGGT TTCCTAAGGT TGGAACCTAG GGTGCAAACT GAGGATGGGC 180

AGATGAGGTG GAAGAGGAAG AG CAGAC CCA GGTCACAAAG ATCTTTTGTG CTAAGGATTT 240

TTAAGCAGGT AGGAGGAGAG AGAATATGAG CCTTGGGATT TGAACTGCTG TGGGTGTACA 3 00

GAAAAAGAGA AACTCAACGA GAGGTTTAGG TTTAGGGACG TGGTAGGCTT TTG CAGTAAG 360

GGACAAGGAC AGAAGG CTCA TCTGAGGATG GGAGGGACAC TTTAGAGGCA AATCCATAGG 4 20

ATGCAGTGGC TGAACAGAAA AGGTGAAT CT CGAG 454

(2) INFORMATION FOR SEQ ID NO: 96 7:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

413

WO 98/45437

PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO:967:

GAATTCGGCC
TTAACAGATT
ATTATCAAGT
TGAAAGCAAG
CTGTATAATA
TTACTGTCGG

TTCATGGCCT
TTGGAAACTG
TATTTCCTTG
AATCTTAAGT
CATGATGCTG
CGAAAACTCG

AGTCATTTAA
GTTTTAAGTA
TTAGCTATTT
TAAATACATG
TTAGCAGCGG
AG

TTTAACTTAG
GATGTATTAT
TTACAGCATG
TTTTTTTTGT
AACGTATCAG

CAAAACTCCA
AACATAAAAC
TGCATGTTAG
TTGTTTGTTT
AGACACGGCA

ATAGTGTAAG
AAAGCTAGCC
GTAGTCATCG
TACTGCTGTG
CCAAAGTATG

(2) INFORMATION FOR SEQ ID NO: 96 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 78 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 968:

60
120
180
240
300
322

GAATTCGGCC
G CCAATC CAT
CAGGTTTTCT
GAAGGGGAAC
TATGGCGCAG
TGGGACCCTG
AACCTGCCTT
GCTATTTTAG

TTCATGGCCT
CAGGGCAGCT
GGCTGCTGGG
GGCTGGGCTC
GAGGGACAAC
GCCTCAGAGG
ATTTG CCAGA
GAGGCTGGTG

AGACTGCTGG
CCGACTCCTG
GTTCCGCACG
GGGCGCCACA
TGGCCCCTGT
CCTGCGTGTC
TGTCCCAGAA
ACAAGCAAGG

CATATCCACC
CAGCACCCAC
AATGGGCCCT
GCTTGTCCCT
GGCCAGCCCC
ACAGCTCAGG
GTACACAGGA
CATGGTGGCA

CCACCTGTGC
CGCCCAGGAC
TCTTTTGGGA
CCAGCCAGCA
AGAGAGACGG
GTCTGGCTGG
GCAGACGCAC
GGAAGCCAGG

TGCTGCCCCC
GTCAGCTACT
AAATGCCAGG
GGCACAGATG
GCCCTTTCTT
GCAGGGGCAA
CACTTCGATG
CCCTCGAG

(2) INFORMATION FOR SEQ ID NO: 96 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 84 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 96 9:

60
120
180
240
300
360
420
478

CTCGAGGTCC CTGTCCTGCT CAGTTTCTCT TCAATGTGGA AGTCCTGGGA GGTCAGTCTC 60

ATGAGAATAA GGTGCTGTAC TTTCACAGCC TTCTCAGACT TTTCTGAGGA TGGCCTTACA 120

CTTGCCAGCT AGTGGAGTGA GCAGAACTCC TCCTGGTTTC TGTGGCTGTT CTCAGAATGC 180

CCTAGTTCAC TTTCCAGTAA TACTTTTTTG GGAACATTTT GTGTTTCTCA TTTTCTCAGG 24 0

TCCCCCAGGC ACACCATCTT TCCTCTGCTT CCTCTCACAC AGGTGCTGAT ACTGTGTAGG 300

TTTGGGGCTG TTGTTCTGGC CCACTCCCTG ATATTTTCTG GGTTTGTCAC CTAGTTTTCT 3 60

TAAAAGTATC ATCTACATGG TTTTGGTTTC ACTATCTATT CTGTCTTTAT TTGAACACTA 4 20

GGGGAAATTC ATTATGC CAA TCTCACACAT TGTGTGATTC CATTAGGCCA TGAAGGCCGA 4 80

ATTC 484

(2) INFORMATION FOR SEQ ID NO: 970:

(i) SEQUENCE CHARACTERISTICS:

(A) . LENGTH: 54 0 base pairs

(B) TYPE: nucleic acid

414

■man

WO 98/45437

PCT/US98/06956

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 970:

GAATTCGGCC
ACCATCTTTG
AATGGTGGCA
AACATCCATG
GCATCCAGGG
CCTCCTCTGA
TCCAGCAAAT
TGGTTCCTGC
GAAGTGGTTG

AAAGAGG CCT
GGATACAATC
ATGTT CAGGA
CAGG AT CATG
TGCTCTCCCG
ACAATCTCCA
ACACCTGGGT
TTGGGTCACC
AAAACACACA

AGG CAAAATG
TCATGGATAC
GACAGTGACA
CTCTTCTACC
AAGAGCCTGC
ATGGTACATC
CAAGTACAAC
CATTGAGAAA
TAATGTCGGT

AAAATACTTG
GAGGTTTTTA
ATTGATAATG
ACAATTTTTG
TTTATCCTGA
TATGAGAAAC
CCTCTGGAGT
CTCTGCAAAC
GCTGGAGGCT

TGGCATTTCT
ACAT CAT C AG
AAAAAAATAC
ACTATAAACA
AGATGGACCA
AGGCTCTGGA
CTCTGATCAA
ATATCCCTTT
GTGCAAAGGC

GGTGGTG CTG
CCCAAGCAAC
CGCCATCATT
TGGCTACATT
TCAGAACATC
CAACATGTTC
AGACGTGGAT
GTATAAGGGG
TGCACTCGAG

60
120
180
240
300
360
420
480
540

(2) INFORMATION FOR SEQ ID NO: 971:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 9 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 971:

GAATTCGGCC TTCATGGCCT AGCCAGTCTC AGCACTTAAA CAACCAGGTG TTGAAGGACT 6 0

ATGTTCCAAA GAACAGAAGA GAGTATGGTT TGCAGATGGT ATATTG C CCA ATGGTGAAGT 120

TGCAGATACA ACAAAATTAT CATCTGGAAG TAAAAGATGT TCTGAAGACT TTAGTCCTCT 18 0

CTCACCTGAT GTG CCTATGG TAAGGAATTC AAAGAATACT TAATTGACTA AACAAAATTT 240

TATTTCGTAG ATAAT TCCTG GTGTGATTAT TAGAGTGCTT TTTCTCGAG 28 9

(2) INFORMATION FOR SEQ ID NO: 972:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 418 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 972: .

GAATTCGGCC TTCATGGCCT AG AG CTTGGG AGGTTGAGGC TGCAGTGAGC TATGAGCTGC 6 0

ACCACTGTAC TCCAGCCTGG GTGACAGGGC AAGACTCTGT CTCAAAAAAC AAAAACAACA 12 0

ACAAAAACTT TATTCCTAAA AAGTGCTGAC CCAGAGATAA G AAG CAAGCA CATGGTTGGT 18 0

AAAATGACAT CAGTGAGCTT GCTTTATGCA GGGTTGCCCC AAACCTTCAA TTTGTAAAAC 24 0

TCAAAATATC TGGAAAGCTT GGTGAGGCGA GGCGGGACTG TAACT CAGC A CTCACCGCAG 3 00

GGTGAGACCC TTAGGGCAGC GGGTG CTACA CTGAACAAAG CGGTGAACAG CCCCCTCGTG 360

AGAGGGGGTT CTTGG CAGAT GACGCCAGCA GCTGACAAAC AGGCAAGTGC AACTCGAG 418

(2) INFORMATION FOR SEQ ID NO: 973:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 276 base pairs

415

WO 98/45437

PCT/US98/06956

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 973:

GAATTCGGCC TTCATGGCCT AGATTTGTAA AAGATTTTCC TAGATTTACT GTGTTCTGGA 6 0

TCTAGCTTGA ACGTGAATGT TTGTATAGTA CGTTTTCTTA ATATTTTTTA GTATTCATAG 12 0

TATATAATCA TACTAAACTT G AGAAACTG G AAGAATCAAG TCTTCCTCAG TTCTGTTTAG 18 0

ACTTTCTAGT TTTTTTTAAG GATACTTCCA TATCTTCTGT AAGCTACACA GTG AG CTTCA 24 0

TTTTTGCACA GTTATAATAC ACTCTCGAAT CTCGAG 276

(2) INFORMATION FOR SEQ ID NO:974:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 37 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 974:

GAATTCGGCC TTCATGGCCT AGGGTTCGAT GATAAGCACA GGCGGCAGCT GGATTGCAAG 6 0

TGGAGTGGTA ATGGCCAGAA CAGCCTCTTT CTGTTTTGCA TTTAGTCGAG GATCCAACTG 120

TTCATCCCAT TGTCTGTTAG GACTCCATGG TATGGTGGGA GTCATACTGA TGTCTGGAAA 1B0

CAAAACCCCA TTGTCCTTGA TCCTGTCTAG TGCATAGTGC ATTTCACAGA GGGGTAATCG 24 0

ATTTAATTGA AACTGAAGTT CAACCTGTGT GTCACAGTCA GGCCGAAGAT TAAGTTCTTC 3 00

ACAGCATTCC CTAGATAGCC TTAAAAATAT ATATTC CTTT GTTTTTTCTT CAATAGT AG C 360

TTCCTAGACC TGCCTCGAG 379

(2) INFORMATION FOR SEQ ID NO: 975:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 417 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 975;

GAATTCGGCC TTCATGGCCT AAGAGAAAGA GAGTGAGAGA GAGAGAGAAA GAGAGAGAGA 60

GATGCTGTTG AATCAGAAAC AGATCAACAG CCCAAAGATT TTCCTGTCCC TGGAGTGCCA 120

GCCCCAGGAA GCTCCAGGGC TGAGTGGTCA GGAGCCAGTT TCTCCAGCCC CTCCTCCCCA 180

CAACCCCTAG TGGGGAGGGG CAGCTGTCCA TTTGCCCAAA GTATTAATGC AACTGAAGCT 240

GTGATATTTC CAACGACTGT AGGAGGAAAA ATTAAGGGGA GAGAGGAAAA CAAAACCAAC 3 00

CAACCCCTAA AATCATTTTC TTATTGTACA TAACGACCTC ATTCTCCTGT ATATGCGGAA 360

GATATAACCT TATATTTGGT AAGTGTTTCT TGTGCTATTT TATCACGCGA CCTCGAG 417

(2) INFORMATION FOR SEQ ID NO: 976:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 154 base pairs

(B) TYPE: nucleic acid

416

WO 98/45437

PCT/US98/06956

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 976:

GAATTCGGCC TTCATGGCCT ACACAGAAAA ATTT CAACAA TAAAAGTTCT TAATTATGGG 6 0

AAATAGTTAC ATGTGTGTTA TAT CATTTAT GGCTCATTTT GTATTTTTAT TTAAAAGTAT 120
TAAAATCCCA ACAGTAACAG CAATACAACT CGAG 154

(2) INFORMATION FOR SEQ ID NO: 977:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 252 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 977:

GAATTCGGCC TTCATGGCCT AAATTGTTCT TTGCTCAAAT AAACTGTTAA ATT TATCTTG
GCAGACTCTA TTTTGATCCC CAAATTTGAT TTAGATTTGG GGCCATTAAA TTTCACTATT
TAATAATAAC CCTACTGGAT GAGAATAAGT GTTTCTCAAT TTCTGGTGAT ATGGTTTGGC
TGTGTCCCCA CCCAGAATCT CAT CTTGAAT TATATTCCCC ATAATCCCCA CGTGTCAACG
GCAGGACTCG AG

(2) INFORMATION FOR SEQ ID NO: 978:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 251 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 978:

GAATTCGGCC TTCATAGCCT AGTTTAGTTC TCAGAATTCT T CAT ATATTT TGGCAGCAGT

TTTTCCATCA GATTATTTTG TAAATATTTT CTCCCAGTCT GTGACTTGCT TTTTCCATTC

TCTTAACAGT GTCTTTCACA CAACAGAAGT TTTTAATTTT AATGAGGCTC AACTTAATTT

TTTTTTCATT AGTAGATTGT GCTTTTGGTT TTGTAT CTAA GAAGCCATCA TTGAACCCAG
GATCGCTCGA G

(2) INFORMATION FOR SEQ ID NO: 979:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 53 4 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 97 9:

417

60
120
180
240
252

60
120
1B0
240

251

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PCT/US98/06956

GAATTCGGCC TTCATGGCCT AGAAGGCTTC TGAATAATTT CT CAAAACT A NCTTTCCATT 6 0

TNAGTACACG ATTTGATAAA CATAGCACAT TAGATAGGTA TTTAGCAATT TCTTCTACCA 12 0

ACTACACTTT GCCCTCACTA AGGGTTAGAG TATGATTTGA AACAATTTCT ACATATAAAG 18 0

CATCTTTAAA TAAGTTTTGT GTTCACTGAA CTGAGACTTC TTTCACTTAT GTACCTATGG 24 0

AAGTTAATCT GAGCATACAC ATATATACAT ACTTGCATAC ATATGTGTAC ATATGTTTTT 3 00

TAAGTAAGTN ACTTTTACCA TTAGAATAAA CCTAGACACT ACAGGGACAA CTCTGGGGAA 36 0

CAGGG CGGTC TGCCTTAACA ACCCTTCTCT AGGTTGAGGA AGGCAGGTAT AGTTCAC TG A 42 0

AGGATGTGAT GAGGCTG TAG TAAG TCTTCT CATCATCTGT TAATCCTGCG TTGCCTGGTC 48 0

TCACCACCAC AGCTACGTGC ACATCTGCTT CCTCAGCAGC ACTGGCCTCT CGAG 53 4

(2) INFORMATION FOR SEQ ID NO: 980:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 223 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 980;

GCTCGAGTGT CGTGCTATCT CTAAATTGTG ATCACTAAGA ACCGCTGCGG AAACAGTAAC 6 0

TGTTTCTTTT ATTTTTGACA TTTTAGTTTG TAATTTATCC AATTCTTTCT TCTTTTGATA 12 0

AGTCTCCATT CTCTTTACTT CACGGGTATT TTCAAATTCA TTAATCATTT TATCACAGTG 18 0

CCACTTGTTA GACCCTAATG AACGATGTCA CCCTCTTATC AAA 223

(2) INFORMATION FOR SEQ ID NO: 981:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 81 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 981:

GAATTCGGCC TTCATGGCCT AATTACTTGA CCCGTAATAG GGTTGTGGCC GTTTTCTGAT 6 0

GCCTAAGTAT TATACAGAGC CCACAATGGC CAGTTTACTA CCAGAAAGGG CTTCAGTAAG 12 0

ATATTCTTGG ACTTGATACT T TCTTCAG AT CCTCTTTGTG CCAAGATAAT TTATCCAGTC 180

ATTGGGAATA GTAAGTTTCT GTGTAACCCA T CT CAATTAT AGAAGCAAGT TCAGCTTTAT 24 0

GTATT TGTAT GGGGAGTTGA AGATTCAGAT AGAGGTATTA AGATGTGTGG CATTTACTTA 3 00

AACCATCACA TTTTTTTCTT TCTACGCCCC CTTGCCTGTA AAACACCTGG GAAGTTCCAC 3 60

TGGTG TCATC CATCCTGATG CTTCAGACCA CCCTCCCTTC TTCACAGACC GTGTCACTTT 4 20

GCCTGTGGGT GGGGGCTAGC CAGCCACCAC CCTCTTTTCT GTGCTGCCAG CCAATCTCGA 4 80

G 481

(2) INFORMATION FOR SEQ ID NO: 982:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 93 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 982:

418

WO 98/45437

PCT/US98/06956

TCCGTGTCCC CTCCTCCCTC TGCCCCCAGT GTTTCTTCTG ATTTTTTTTT CCCCTTTCCC 6 0

TCCCTCCCTC TCCGCATTCT TCCCTTGGTT CAG CACAGGT AAAACGGTTC CCCTCCCTCC 12 0

CTGCCTTCAT GGATCACCAG CTCACGTCAT GTTGCCTTCT CTTTTCTTTG TGTGTGTGTT 180

TATTTAAGTT ATTTTTCTTC CTCCTCTCCC TTTTCTTTTT GGCCCTCCCT CCCTCCCTCT 24 0

TCTGCCATGT AACTGGAGGA TGTGCTATGA GTTTGCAAAC AGCCGGACTC GAG 2 93

(2) INFORMATION FOR SEQ ID NO; 9 83:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:983:

GGTGAGGATG GTGGCTGTGG TTGTGTTGGT GGCTGTGATG GTGAAGGTGG CTGTGGTGGG 6 0

GATGGTGACT CTGATGCTAA TGTTGGTTGT GGTGATGGAG GCAGCTGTGG CAAGGATGGT 12 0

GACTTTGGTG GAGAAGGTGG CCATGTTGGG GCTAGTGGCT GTGGTTGTGG TGATGGCCAT 180

GGTGAGGATG GTGTTAAAGG TGG CTGTGAT GAAGATGGTG ACTGGGGTAG AAATGGTGAC 24 0

TGTGATGGTA ATGTTGGCTG TGGTGATGAA GGGTAGTTAT GGTGAGGATG ATGACTATGG 3 00

TGGTGAAGGG GCCATAGTGG CAACGGCACT CGAG 33 4

(2) INFORMATION FOR SEQ ID NO: 984:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 631 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 984:

GAATTCGGCC TTCATGGCCT AGGGAAAGAG TAGGGGTGGA GGGGTAGGAG GATTTACTCT 60

TCCAG CGAGA GCTACGCGCA TCCCATCCTC CCCCTCCCCC CTACCCGGGC TCCGGCNTGG 120

AGGCGGGGCG TGGCCGGCCT GCTTTGGGAG GGGAGGGGCT TCCCTTACAG TGCTGGGCTC 180

TGCCAGGACG GCTGTGGGGT CGCCTTACCT CGGGGTATCC ACTCTGCAGT CGACCAGTTC 24 0

CCGCCAGGAG CAAAGGGTAG GAAGGAGAGC AGGATCTGCT GTAGGAACGC AGCTACCGCG 3 00

CCACTATCAC GAAGAAACAG CAGGCTCGGG GCACGAGACG AACTGGAGAC CGCGCTGCCT 360

AGCTGGGTAA CCTGGGAAGC AGAGGGTAAT AAGTGGCGCC TTAAGATAAC CCTGTAGCAG 420

CAGCAGTGGC GGCCAAAGGA GGCTGCTCAG GGAACAAGCG GCTGTAGTAG TCTGTGGGGC 4 80

GACTGGAGTG ACCGAAG CCA AGGCAGTTTA GTGCCTCTCG TGTTCTTATT TTTTAACCTC 54 0

TGACTATGCA ATTCTGAAAC CTCCCCCATT CGGGGGACCA GACAGCCTGA TAGACACCTT 60 0

CCACTCTCCT TCCTCCCGCC GTGGTCTCGA G 631

(2) INFORMATION FOR SEQ ID NO: 985:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 324 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

419

WO 98/45437

PCT/US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 985:

GAATTCGGCC AAAGAGGCCT ACTGCCTCGG TTTCTACCTT TGCCAAATGA GTTGATAGAT 60

TATCGCTTTT TTTCCAGCTG TCATACTCTA GGAGTCTGAA TTGTAAAATC AAAG AAG CAT 120

TTCCCAGAAA AGTTTTTGTC AAAAATTTGA TTTACATAAC CTCAGAAATG TGTATTGCTT 180

TAAAAATTAT AAAGTTCATG GAGCATACCA AGCAGCCTGT ATACCATTTC TAAACCAACT 24 0

ACTCCCCTGC AAGATAGATC TCTTTTTTAT AGACAGAAAA TAAATTCAAA GAGGTTTGTT 300

ACTTGCCCAA GGCCACCACT CGAG 3 24

(2) INFORMATION FOR SEQ ID NO: 986:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 23 9 base pairs
■(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 986:

GAATTCGGCT TTCATGGCCT AAAATGTTTT TCAATTAAAG ACTTAAATAT TACACTTTTA 60

AAACTT TTTA TTATGGAAAT CTAAAAAAAA TTCACCAAAT GAGAGAGAAC ATTACAATGA 12 0

ACCACCACAT ACCCATCACC CATTTTCAAC AATTATCAAC ACATGG CCTA TCTTGTTTCC 180

TCCATACCTT CAGACACCCT CCGTCCACAA ACTGGGTTAT TCTGAAGCAA GCCTTCGAG 23 9

(2> INFORMATION FOR SEQ ID NO: 987:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 695 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 987:

AAAAGTTCAG GGACTTTGCA CCCTGTGGGG TACTCAGATG TCCAGCCGCA CTCTCTACAT 60

TAATAGTAGG CAACTGGTGT CCCTGCAGTG GGGCCACCAG GAAGTTCCGG CCAACTTTAA 12 0

CTTTGCTAGT GATGTGTNGG ATCACTGGGC TGACATGGAG AAGCTGGCAA GNGACTCCNA 18 0

AGCCCACCCC TGTGGTGGGT GAATGGGAAA GGGAAAGAAT TAATGTGGAA TTTCAGAGAA 24 0

CTGAGTGAAA ACAGCCAGCA NGCAGCCAAC TTCCTCTCGG GAGCCTGTGG CTTGCAGCGT 300

GGGGATCGTG TGGCAGTGAT GCTGCCCNGA ANGCCTGAGT GGTGGCTGGN GATCCTGGGC 360

TGCATTCGAG CAGGTCTCAT CTTTATGCCT GGAACCATCC AGATGAAATC CACAGACATA 420

CTGTATAGGT TGCAGATGTC TAAGG CCAAG GCTATTGTTG CTGGGGATGA AGTCATCCAA 4 80

GAAGTGGACA CAGTGG CATC TGAATGTCCT TCTCTGAGAA TTAAG CTACT GGTGTCTGAG 54 0

AAAAGCTGCG ATGGGTGGCT GAACTTCAAG AAACTACTAA ATGAGGCATC CACCACTCAT 600

CACTGTGTGG AGACTGGAAG CCAGGAAGCA TCTGCCATCT ACTTCACTAG TGGGACCAGT 660

GGTCTTCCCA AGATGGCAGA ACATTCCTAC TCGAG 6 95

(2) INFORMATION FOR SEQ ID NO: 98 8:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 314 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

420

WO 98/45437

PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION; SEQ ID NO:98B:

GAATTCGGCC
CCCAAACCAG
AGACCCCTTT
CACACAGCAA
CAGCCACCAT
AGACCTGCCT

TTCATGGCCT
AAAAACCCCA
TTCTTGAAAA
TTGACGCATC
CCCCATATTC
CGAG

ACTCAGAACA
CTCAGGTCTT
AGGGACTTCA
TCACGGCACT
GTAGTAAGAG

ATCACTGCAT
GCTGACCCAA
CTTTTTTGAG
GCTCTCTGCT
AAACTCCAGA

ATCCCATCTT
CACTACAGTC
CAGCATTCTA
GGGCAGAGAG
AACGCAGCCA

AAAGGCAAAA
ACTGTATTTG
TGGTTCTTTC
CAAACACAGA
CCGTCCCCCT

(2) INFORMATION FOR SEQ ID NO: 989:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 68 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 989:

60
120
180
240
300
314

GAATTCGGCC AAAGAGG CCT AGGAGCTCCC CCATGGATCA TGGCGTTAAT GTTTACAGGA 60

CATTTACTAT TCTTAGCATT ATTGATGTTT GCTTTCTCTA CTTTTGAGGA ATCTGTGAGC 120

AATTATTCCG AATGGGCAGT TTTCACAGAT GATATAGATC AGTTTAAAAC ACAGAAAGTG 180

CAAGATTTCA GACCCAACCA AAAG CTGAAG AAAAGTATG C TTCATCCAAG TTTATATTTT 240

GATGCTGGAG AAATCCAAGC AATGAGACAA AAGTCTCGTG CAAGCCATTT GCATCTTTTT 3 00

AGAGCTATCA G AAGTG CAGT GACAGTTATG CTGTCCAACC CAACATACTA CCTACCTCCA 360

CCAAAGCATG CTGATTTTGC TGCCAAGTGG AATGAAATTT ATGGTAACAA TCTGCCTCCT 420

TTAGCATTGT ACTGTTTGTT ATGCCCAGAA GACAAAGTTG CCTTTGAATT TGTCTTGGAA 480

TATATGGACA GGATGGTTGG CTACAAAGAC TGGCTAGTAG AGAATG CACC AGGAGATGAG 54 0

GTTCCAATTG GCCATTCCTT AACAGGTTTT GCCACTGCCT TTGACTTTTT ATATAACTTA 600

TTAGATAATC ATCGAAGACA AAAATACCTG GAAAAAATAT GGGTTATTAC TGAGGAAATG 66 0

TACGAGTATT CCATGGTCCG TCTCGAG 6 87

(2) INFORMATION FOR SEQ ID NO: 990:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 677 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 990:

GAATTCGGCC AAAGAAGGCC TAGAGCCCTT CTGTCCCTTC TACCATGTGT GGATGCAGTG 60

AGAAGGCACC GTATCTCTGA AG CAG AG AG C CCGCCCTGGA CACTGGATCT GCTGGCACCT 12 0

TGATCTTGGA CTTCCCAGCC TCTAGAACTG TGAGAAATAA TTTTTTGTTG TTTACAAATT 180

ACCCAGGCTA AGGTG TTTCA TTGTAACCTG AATGGACCAA GCTGGTGTGA CCCTGTTGGA 24 0

AAACTGG CAG TATCTACCAA AAGCCGAACA TACGTATAAA CTGATCCAGC AGTTCCACTC 3 00

CTGGGTATGT ACACCACAGA AAGCTATGTC CACCGAGACA TTGGCAAGAA TGTTTCTAAC 3 60

CACACGCTGA CTGTAGCCCC AAACCTGAAA CAACCCAAAT GTCCATCCAC CAACCCAAAT 420

GTCCATCCAC AGTTGAAGCT ACAGTGAAGT CACAGGGTCG AATACTACTG CACAGCAACG 4 80

AATATGAATG AAAATATCGC TATG CACAGC AACATGGATA AATTTCACAG ACATGAGGTC 540

AAGCAAAAGA GGTCAGAGTC CTCATCATCA AGAGAGAATT CATTGTATGA TTCTCTTCCT 6 00

ACAAAAAGTA CAGAAATAAG CAAAACTGAT CCATGGTGTT AGAAGCCAGG GGAACAGTTA 660

421

ACAAGGG AG C ACTCGAG

(2) INFORMATION FOR SBQ ID NO:99l:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 445 base pairs

(B) TYPE «. nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 991:

GAATTCGGCC AAAGAGGCCT AAGAAGCTGC TTCCTCCTGG GAACAACCGC CTCCCGCTCC
TAGCAGGTTG CTACTGCCCC GAACCCGCGC TGCAGGGAAC AGCGGGGCAA ACAAAACCAA
TAGAGCCATG GCGACTCCCT CTGCTGCCTT CGAGGCCCTT ATGAATGGTG TGACAAGCTG
GGATGTACCC GAAGATGCTG TTCCATGTGA ACTG CTTCTT ATTGGAGAGG CTTCATTTCC
TGTGATGGTG AATGACATGG GCCAGGTCCT CATTGCTGCC TCCTCCTATG GCCGTGGCCG
CCTGGTGGTC GTGTCCCATG AGGACTACTT GGTGGAAGCC CAGCTCACGC CCTTTCTCCT
GAACGCAGTG GGGTGGCTTT GCTCTTCCCC TGGGGCTCCC ATTGGTGTAC ACCCATCCCT
GGCACCTTTG GCCAAAATCC TCGAG

(2) INFORMATION FOR SEQ ID NO: 992:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 3 92 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 992:

GAATTCGGCC TTCATGGCCT ACTGTGATTT
TGTTGGTTCC AAACCCTGAA TCTTTTGGGG
TCTAAGCTTT GTTTAATGGT GTGTGTGTGT
ATTGGCTTCT CTGGGTTCCT CGCTCGTCTT
AATTCTGAAT GTTTTATAAA TTAGACTATT
ATAAGACCTT CCAGGAATTC CATTCCAAAT
CAAACATTGG GTGTTTGGGA GGTGGACTCG

AAAATCTTGC TGTGTGGCTT GGGTTGTTTG
TCTTCAATTT GTGGGCATGT CAGTGGAAAT
CTGTCTGTCT CTGTGTGAGT GTGTTTAGAA
CTGGAAGGTG GGGTTATAGA CATGCTGGTG
AACGGAGTTA AATTGAAGAA ACCTTCTGTC
GAGGAAATGC ATAAAGACTT GTCCACTTGG
AG

(2) INFORMATION FOR SEQ TD NO:993 :

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 59 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:993:

GAATTCGGCC TTCATGGCCT
AGTGCGGGCG GCCTTGTTCC
GGTGTCCCCA CTGAGCTCTT
AGTATCTCCG T ATT CTGGAG

AGGCGGCTCC CTTGGTCCTG
GCTCCAGTCT GGCCGAGTTC
GGAAGAGAGT GGTTGAAGGC
CAGTATTTCA TGAAACTCCA

GTGCTGGTGG TGGCTGTGAC
ATTTCCGAGC GGGTGGAGGT
CTTTCACTGT TGGACTTGGG
TTAATAATAT ACCTCTTTCA

422

WO 98/45437

FCT7US98/06956

TTTCCTAATT GACTATGCTG AATTGGTGTT TATGATAACT GATGCACTCA CTGCTATTGC 3 00

CCTGTATTTT GCAATCCAGG ACTTCAATAA AGTTGTGTTT AAAAAGCAGA AACCTCGAG 3 59

(2) INFORMATION FOR SEQ ID NO:994:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 115 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 994:

GAATTCGGCC AAAGAGGCCT AGACTGTCAG CTGTGAGTGG CCAGTACAAC AAATGCT TTG 60
GCTTTCAGTT GTCATTCTGA TGTCTTGCAA CATATCATCG TGTTTGATTC TCGAG 115

(2) INFORMATION FOR SEQ ID NO:99S:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 633 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 995:

GAATTCGGCC AAAGAGGCCT AGTGGAGACA AAAGCATGTG ATCCCAATTT GCTGGGATAT 60

CCTCTCCTGC ATTTCAAACA CCTTCACTCA GTGTCAGCCA CAGCGGCCAC CACATAGCAG 12 0

CTGGCCCCGC ACCTTCTCTG GAACAGTCTG GAGATGCAAG GTCAGGGTGG AAGGCCTGGT 180

TCACCCTTGA AAGAAAG G AT GGCTAGGGGT AAACAAGACG AGCAACTCCC TGGAATGCAG 24 0

GG AG CCAAGA AGGGCAGCCG AGGATAAGGC TCTGCCTCCC CAACGG CGAG GGTTTCCTTT 3 00

CCTTCTGGTC ATTANAACTG CACAGCCCCC GGGGAGATGT TGAACATGGC AGGGTCGAAT 3 60

CGCTGGCCTC GGAAGGGAGA ACTTCAGCAT CCCACCCTTC TTCAGCATCT CATGGACTTT 420

CAGCTCATGG CTCTGTGGCT TGCCCTGCAG CTTCTGGTGG TAGTCAAAGG TAAGCCTGTC 4 80

CAACACCGCC TGTTCCTCCT CATCCACGGT GGCCATGGAG CGCTCCTTGT TGATCTTGTC 54 0

AATGTCGATG GGCTCTTCTC CCTCCAGGAT GGCGTTCCAC CAATACTCGC CCACCTTGCT 6 00

CAGGTTCACC AAAACGCACT TCCCGGGCTC GAG S3 3

(2) INFORMATION FOR SEQ ID NO:996:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 62 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 996:

GAATTCGGCC AAAGAGGCCT AGTTGATTCT CAGTTCATGG TGGAGTCATT CAAGTTTATT 60

TCTGGCATCT TGGCAGCCCT GAGTGCCATG ATCTCTCTAG AAATTCCGCA AGTCAACATC 120

ATGACAAAAA TGGATCTGCT GAGTAAAAAA GCAAAAAAGG AAATTGAGAA ATTTTTAGAT 180

CCAGACATGT ATTCTTTATT AGAAGATTCT ACAAGTGACT T AAGAAG CAA AAAATTCAAG 24 0

AAAC TG ACTA AAGCTATATG TGGACTGATT GATGACTACA GCATGGTTCG ATTTTTACCT 3 00

423

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PCT/US98/06956

TACGATCAGT CAGATGAAGA AAGCATGAAC ATTGTATTGC AG CATAT TG A TTTTGCCATT 3 60

CAATATGGAG AAGACCTAGA ATTTAAAGAA CCAAAGGAAC GTGAAGATGA GTCTTCCTCT 420
ATGTTTGACG AATATTTTCA AGAATGCCAG GATGTACTCG AG 4 62

(2) INFORMATION FOR SEQ ID NO: 997:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 54 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 997:

GAATTCGGCC AAAGAGGCCT AGCTGGTAAC ACATGTGAAC TCAGGTAAAG TCATCGAGCA 60

TTTTACTGAC TCTATTCCTC AATAAAGTAC TGGGAAAAAA CTCATAAGAA TGACAAAAAC 120

AACATACTCA GGTATGCGAG CAGAAGCCTC TGACACAGCT TGTCTTCGGG GCTTAACTAA 180

ATGATCTATT TTAATGAGGG AATCCGTGGA AAGGCATGCG TTTTCAGGCT CATTTTCTGC 24 0

TTCGATGCTT TGTCCAGAGA GTTGGAATCT CAACGTGTGT TTCATGTGAG GCTCCTTAAG 300

AGGGTGACAT TCAACATCCC AAAACTGGGC ATAATCCCCC CTACCTCTGG GCAAAAATGT 360

GATGGAGACT TTTTGGATCC CATGGCTTTC CAGCAGACCA GAAATAGGAG AACATCTGAA 4 20

TGCTGCATAG GTAGCTCTAA AAACATCTCC ACTTTCATCA ACTCCCTTGA CATAAGGTGG 4 80

CACCACAGAC GTGAAATGGC ATCTGTCATC TTTAGCGCCA CCTTATGTCA AGGGAGTTGA 540

TTCTCGAG 54 8

(2) INFORMATION FOR SEQ ID NO: 998:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 572 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 998:

GAATTCGGCC AAAGAGGCCT AGTTTCCCTT TCTGTATTTT ACTACTAAAT TAGAAAGCAC 60

TGGTTATGTA ATAAGTTACT ACATTGCTTT GGTTGAGTAA AAACAAGAGT ATATATTTTT 120

CTTGTTTCTT ATTTNCTAAA CCCTTAACTC CTGCTGAGGT CATAACAACC TCAGTCTAAG 180

CTCTGTGTCC ATCATACTGT TAACTTAAAC AAATGGGTGG TGGGGGTGGG AAGGGTAATA 24 0

CAGTCCTGCC ATTGCCTACC AGTAGGAGAG T C CAAACAG A ACACT CTTTT GAGTAGCAAT 3 00

TATTTAATTT GCCCAGTCAA GGCACCGTGT TTATATACTA TTTCACATTG AATTTGATTA 3 60

TGCCCTACAG ACCTGGCTGG TCAAGGATTT GATATACACA TATTGGCTTG GGATTCGAGC 420

TTTCTTTTTT ATTTAAATAA AAATTTATAT ATATATTATA TATATACATA TATACATAGC 4 80

TATATCTGTA TATATATTGG GTATGTTTTA AGGATTTTTT CGCATGAGCG CAGCTGTTGC 54 0

GATAAATTGA CCGATTGGGA GGTATTCTCG AG 572

(2) INFORMATION FOR SEQ ID NO: 999:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 629 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

424

WO 98/45437

PCT/US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 9 99:

GAATTCGGCC AAAGAGGCCT AG AGGGGAG C ACGTCTTTTC CTTGAGTGTA ATTCACTAAT 6 0

GACTGTGGTT CCAAGGAGGT GCGACCTTTA AAGGGAATTG GCCCTTCTTT GAAGGCAGGT 120

GAGAATCTAG TCTCAGTGAC AACCCAGCCT GATTTGGAAG GGGGGAGTCA TAAGGGTTTT 180

CGCCCAGCAC ACCAGGGTTG CAGCCTGCGC AAGACCTTCC ATAGCTATTT CTGCCGGCTT 24 0

GCTTCCTTCC CTTCCCAGCC ACGATGAGGC AGCTGAGGGT TGCCACGGAA ACCGGCTCTG 3 00

TCCTCCCACT GGAGGCTGCC AGCTCTGATT TCCTGCAGAG TTAAGAAGGA GGCGGCAGTG 3 60

GGGGTCACCC AGGCGTGAAG ATGGGTTTCC CTGGGGATAT CCTGCCTCCT G C CAATC AC A 4 20

GCGTCTCTCT GGGAATCCTG GGGGTGCCTG GAGGCTGAGG CCCAGGGAAG CCCCCAAACC 4 80

CCAGTGCTGC TCTGAGAAGA G ACT AG C C T C TGGGACATTC AGAGGTCTGG GGTTCTTTTA 54 0

TCTCCCTCCA GCTAAAGCTA GAGGGACCTC ATTATGTGTC TTACAAGATG TACCCTAAAC 6 00

CGTCGATTGA ATTCTAGACC CGCCTCGAG 62 9

{2) INFORMATION FOR SEQ ID NO: 1000:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 568 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1000:

GAATTCGGCC AAAGAGGCCT ACCTGTATGC TATTAACACT CACCACAGCA GAGAGCTGAG 60

GATTGTGGTT GCAATTCGGA ATAAACTGCT TCTGATCACA AGAAAACACA AC AAG C CAAG 120

CGGGGTCACC AGCACCTCAT TGTTATCTCC CCTGTCTGAG TCACCTGTTG AAGAATTCCA 180

GTACATCAGG GAGATCTGTC TGTCTGACTC TCCCATGGTG ANGACCTTAG TGGATGGGCC 240

AGCTGAAGAG AGTGACAATC TCATCTGTGT GGCTTATCGA CACCAATTTG ATGTGGTGAA 3 00

TGAGAG CACA GGAGAAGCCT TCAGGCTGCA CCACGTGGAG GCCAACAGGG TTAATTTTGT 360

TGCAG CTATT GATGTGTACG AAGATGGAGA AGCTGGTTTG CTGTTGTGTT ACAACTACAG 420

TTGCATCTAT AAAAAGGTTT GCCCCTTTAA TGGTGGCTCT TTTTTGGTTC AACCTTCTGC 480

GTCAGATTTC CAGTTCTGTT GGAACCAGGC TCCCTATGCA ATTGTCTGTG CTTTCCCGTA 54 0

TCTCCTGGCC TTCACCACCG AACTCGAG 568

(2) INFORMATION FOR SEQ ID NO: 1001:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 3 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1001:

GAATTCGGCC AAAGAGGCCT AGTAATACTT AAAGTGCAAT TGTTCCAAGG CTTTTGTTTC 6 0

CATCATCACA AATATTATAA AGAAAGAGCT ATGTTTAGGG TGAAGAAGAT ATGGCACAAG 120

TAATATGTAA AGAAC TTATG ACTTTCGCAT CCTCTAGCAA ACAGTAAGCT GCCTGTACAG 180

CTGCACACAG ACGGACTTTA CACAACAAAC TCTGGAACTT CATCATGAGT GAGATCCAGA 24 0

GAAAAGTATT TGCTGGTTCT TTTGACTGGA AAAG CATCTT GGATGTTGAT GCACTGCTGG 300

GCCAAGCAAC TGTTG CAATA GAGGCCTTCC TCATCCAGTT CATGGCCACA TCCAAAGGTG 360

TAACTCTGAG CAGTGTCCTG ACACAGACCT GCAATGCG C A GGAAGTCTTT CTGGTAAAGT 420

CTGATGTCAT CGAGGCTCAA GCTGTGTCGA TCAGTGGAGG TCTTTGGTTT CCGACATATA 4 80

GTCTGTGGAA GAGAATCAGT ACTCTGGCCA CGAAGCTTAA CAACTGTTTC TGAAGAGCTC 540

GAG 543

425

WO 98/45437

PCTAJS98/06956

(2) INFORMATION FOR SEQ ID NO: 10 02:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 592 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1002:

GAATTCGGCC AAAGAGGCCT AATTCCACTT ACGAATTAAC ACTGTGTACA TGGCACCTTT 60

GGGCCCATCT TGCCTTGAAA GTCCCTGTTG G AT GGAACAG TGGCATTTTC CTTCCTTTTC 120

TCAGGACTGC AAACAGACCT AATATTTGGC CTTGCCCTTG CCTGGGAAGC TGCTGCTGAG 18 0

TCTTGTCTCA GCCGGGCTGT GCATTCCGAG CGGCTGCCCT GCCCTGCGCT CAGCAGCTGG 24 0

AAT CAATCTG CCCACCTCCT TAAGAAGCCA CTTCATCAGC GGTCACCCGG CAGCTGCTCG 300

CCTCCCAGGG CTGCCGGGCT AGGGCTTTAT CGCATTTTTG AAATTTCAGA TTTCTGTGTC 3 60

TGGGCTATGC CCCTCGAACA GTAACAGCAC CGCTTTGCAG CAGGGAGGAG ATTTCACCAG 420

GATATGGAGG GGACAGGAGA AAAGCCCTCC TTCCCAGAGT CC ACTGT CAT TCAGGATTTG 4 80

CTCTCAAAGA GGCAAGAAAT CTCTAAGAAT GAAAGGAGGT GTTT TGTTGT TGTTGTTGTT 54 0

TTTTGTATGT ACTGGGAGGA AATGGCTAAT CTTGGGTATG CACACGCTCG AG 5 92

(2) INFORMATION FOR SEQ ID NO:1003:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 584 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1003:

GAATTCGGCC AAAGAGGCCT AGGCTCCGTC TGTTGGGGGG CGAACACGCC GCGGTCCTCG 60

TCGTGTGAAG TAAGAACTCT GCTAGAGAGG AAATGGCTGC TTCATCATCA TCCTCCTCAG 120

CTGGTGGGGT CAGTGGAAGT TCTGTCACTG GATCTGGTTT CAGTGTCT CA GACCTTGCCC 180

CACCACGGAA AGCCCTTTTC ACCTACCCCA AAGGAGCTGG AGAGATGTTA GAAGATGGCT 24 0

CTGAGAGATC NTCTGCGAAT CTGTTTTTAG CTAT CAAGTG GCATCCACGC TTAAACAGGT 300

GAAACATGAT CAGCAAGTTG CTCGGATGGA AAAACTAGCT GGTTTGGTAG AAGAGCTGGA 3 60

GGCTGACGAG TGGCGGTTTA AGC CCATCGA GCAGCTGCTG GGATTCACCC CCTCTTCAGG 420

TTGATACTGC CTGGATGGTC ACCTCTGGTG CGCAGCAAGT GCAAAGCCAG TGGGGGACTT 4 80

TCTCACAGCT T ACATAG CCA TCCAGAGATC CACAG CTACG TCACTGAATT GTTAATGCAC 54 0

ATTTGTACTT GGTTTCTCTG TATCTATTCA CAGGCGAACT CGAG 584

(2) INFORMATION FOR SEQ ID NO: 1004:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1004:

GAATTCGGCC TTCATGGCCT ACTTTCTCAT TCCCTAAGTC ATT AG AAAG C ACCAGTTCTA 60

426

ACTCCAAATG ATGACATGGT CTTATTTTAT CTATTAACCA TAAGCTTACA G ATT CTAGTG
AAGAAAAAAC TTTAGGAGGC TACATGGTCT ATTGGAGAGT GTAGGCTCTG CAGTCAGAAG
ATCCCTACCC AGGCTTCTGT CTTTCTCAGT AAGACTTGGG ACCACAGCAA GGTCCGCAAT
CTCCTGAGGC TCTGTTTTCT ATGGTTGGGA TAACATGGTA AGTTATTTTC TTCTAAGTAG
TCACACATGG AAATCTTATC TAAAATTTTA TACCATTAAC TTTTATTTCA CTTATTAACT
CATACCATTA ATACTTTACT TTAGCTATGT TTGGTATGCA TGAGTTGATG AGTGATTAGA
GTACTATGAG CGATCTCGAG

(2) INFORMATION FOR SEQ ID NO : 1005:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 426 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY ; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1005:

GAATTCGGCC TTCATGGCCT ACTCAGTTGC AGATTCTGGC CAACATGGAC AG CCAGCTAA
AAGAGCTACA- GAGTCAGCAT ACCCATTGTG CCCAGGACCT GGCTATGAAG GATGAGTTAC
TCTGCCAGCT TACCCAGAGC AATGAGGAGC AGGCTGCTCA ATGGCAAAAG GAAGAGATGG
CACTAAAACA CATGCAGGCA GAACTGCAGC AGCAACAAGC TGTCCTGGCC AAAGAGGTGC
GGGACCTGAA AGAGACCTTG GAGTTTGCAG ACCAGGAGAA TCAGGTTGCT CACCTGGAGC
TGGGTCAGGT TGAGTGTCAA TTGAAAACCA CACTGGAAGT GCTCCGGGAG CGCAGCTTGC
AGTGTGAGAA CCTCAAGGAC ACTGTAGAGA ACCTAACGGC TAAACTGGCC AGCACCATAG
CTCGAG

(2) INFORMATION FOR SEQ ID NO: 1006:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 402 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1006:

GAATTCGGCC TTCATGGCCT AG AGTAG CCA GGGAGCTGGA AGTTCCACAG ATTGGTTTTA
ATAAACAAAC TCCCTCAATG ATGAGTGGTC TTTTGAAGAG CATGGTTAGA ACTTGGGATT
GTGCTTCTCA TGACTACAAA TGTACTTGTA GCTTAGGTGC AAAAGGGTAG GTCAGTGGGT
AGCTAACTAC TGAGGATTGA TTTTCCTGAC GCTGGTGTTT AAGTGTCACC CAGAACTGGC
ATATAAAGTG GCTCATTCAC CCAAGTATCT TCCTTTCCTT TTTACAAAAT CCTTGGCTGT
TGTGGGGCCT ACATCTCTTC ATGATTATTA T TG CATCTGG TGTCATGTTT TTCCAGCTGG
TGTACTGCTT CCCTGTAGGC TTCTTGATGT TCACTCCTCG AG

(2) INFORMATION FOR SEQ ID NO: 1007:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 56 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1007:

427

WO 98/45437

PCT/US98/06956

GAATTCGGCC TTCATGGCCT ACTGGTGCCA CGGGAGGCAG ACACCAAGTT CTGGGGTCTC 6 0

CAGCTGCAGT GGGTGGCCGC CAATTGCTTC TCTCTGTCCA GACTAATGAG AACATGGAGA 12 0

TCACCAGTGC ACTGCAGTTG GAATAGCACG TAAAGAGGGA GCTGGGAAAG AAGCTGGGCA 18 0

AG CTAAAGG A CATGGTAACC CTGCCCCATC CAAGAAGAGC TGGAAGGCGG GCACCAGCCT 24 0

CTGGGGAGGG GAGGTGTGAA GCCAGAGGCA GCTCCAGCCT GGGGGACAGG TGACCCCAGC 300

ACCCTCCAGG GCAGTCCTGT GACTGTTTCT TGCTTCCCGC CCTCTGACAT TTAGTGGTGG 360

GTTCGTTCTT CCTAGGTCTG GACATCATCA TCCCAGCTGG AGTCATGGAG CCTCCCAAAC 42 0

ATAGGGAAAG AGATGGTGGT ATAAGAGGCT CTCGAG 4 56

(2) INFORMATION FOR SEQ ID NO: 1008:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 564 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 100 8:

GAATTCGGCC AAAGAGG CCT AGGATGG CTG TGTTTGACGG GTGTTGCTCG TGACAGTTGG 6 0

GGTCCTCCTC AG CAT CAGT C TTGACATGGC TGCAACTGGG GGGGTCCTCG GGATCCTCCC 12 0

GGAATCTCTT CCTCAGCATT CGCTCATGAT AAGGTTTCAG GTGTCTTGAT GGTTCAGTCC 18 0

TGGAGAAACA TAAGCATAAC CTCTACCCCA AGTTATTATT TTACCTATTT CCCAACTTTC 24 0

TGTTATCAGG TCTCTCCACC AAACCAGTTG TTCTGCTTCT GTCTTTGCAG CTGGTTTCTG 30 0

TAGATGCTGT TCAGCTGCTG ATAAGATCCG GCCTTTAGGC AGGCTCAAAA AATTTAAAGT 360

TAATAATGCG ATTCAATTGC TTATGGGGTG TCCTGTAGTA CCTGTTTTCC CCCTTTTGCT 420

TCTGCAACTG CTGTTTCAGG GAGAGATTCA TTCTTTCCAC TATGGCNTGT CCTTCAGAAT 480

TATATGGGAT ATCAG TAATG TGTTTAATAT TCCGTATAGA GAAAAATTTA GCTAGAGCTT 54 0

GAGAATTAGG TTCCAATCCT CGAG 564

(2) INFORMATION FOR SEQ ID NO: 1009:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 661 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1009:

GAATTCGGCC AAAGAGGCCT AGAAAAAGAT GTCATTC CGT AAAGTAAACA T CAT CATCTT 6 0

GGTCCTGGCT • GTTGCTCTCT TCTTACTGGT TTTG CAC CAT AACTTCCTCA GCTTGAGCAG 120

TTTGTTAAGG AATGAGGTTA CAGATTCAGG AATTGTAGGG CCTCAACCTA TAGACTTTGT 18 0

CCCAAATGCT CTCCGACATG CAGTAGATGG GAGACAAGAG GAGATTCCTG TGGTCATCGC 24 0

TGCATCTGAA GACAGGCTTG GGGGGGCCAT TGCAGCTATA AACAGCATTC AGCACAACAC 300

TCGCTCCAAT GTGATTTTCT ACATTGTTAC TCTCAACAAT ACAG CAGACC ATCTCCGGTC 360

CTGGCTCAAC AGTGATTCCC TG AAAAG CAT CAGATACAAA ATTGTCAATT TTGACCCTAA 420

ACTTTTGGAA GGAAAAGTAA AGGAGGATCC TGACCAGGGG GAATC CATGA AACCTTTAAC 480

CTTTGCAAGG TTCTACTTGC CAATTCTGGT TCCCAGCGCA AAGAAGG CCA TATACATGGA 540

TGATGATGTA ATTGTG CAAG GTGATATTCT TGCCCTTTAC AATACAG CAC TGAAG CCAGG 600

ACATGCAGCT GCATTTTCAG AAGATTGTGA TTCAGCCTCT ACTAAAGTTG TCGATCTCGA 66 0

G 661

(2) INFORMATION FOR SEQ ID NO: 1010:

428

WO 98/45437

PCT/US98/06956

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 316 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 101 0:

GAATTCGGCC TTCATGGCCT AGGAAAGATT TGACTGCTTC TCTCATGCAG GGGAATAAAG 60

CAAAGGCACG TGCAGAGGGA AGTAGGGGTA GAGAGAGGCA AGTTAGCTTC AGAGAGATTT 120

ATTTGCACCC AGTTCTGTTC TACTCAGCCT GACGTTTTAT CATCTTTTTG AAAAGTGGCG 180

TGAAGTGGTG TGGAACACAT CAGAGGG TG A AGCCGAGCAA ATCTGAAAGA GAG CAG AGG A 24 0

TTTCATATGA TATCCTATGT GTGCTTTCCC CTTCCTTCTT AGGAGCTGGA AG AGG C AG AA 3 00

TTGATGTCCA CTCGAG 316

(2) INFORMATION FOR SEQ ID NO: 1011:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 4 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1011:

GAATTCGGCC TTCATGGCCT AGAAACATGC TAGACATTTT GAAGAACCAG CAAGAATGTT 60

AGTGTAGCCA ACAGTGAGGC AGGCAAAGGT GAGTAAGGTA GATTAGTTCA GGGAAGAAAA 120

CATAACATTA TTTAATCCAT TGTGGGCCAC ATTGCACTAT GATAACACTA TCATGTCATA 180

GAGTCTCACC ATTGTTTAAG ATGTTTAAAT TTTTTAATAC GAATATATTC TCACACCCCT 24 0

CGAG 244

(2) INFORMATION FOR SEQ ID NO: 1012:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 55 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1012':

GAATTCGGCC TTCATGGCCT AGCACTTCCC GAGACTCTCT AGCCTTGGAT AAAGAGAGAA 60

TGGATAAAGA TCTGGGATCT GTGCAGGGAT TTGAAGATAC AAATAAATCC GAGAGAACTG 120

AGAGTCTGGA AGGAGATGAC GAGTCCAAGT TAGATGATGC ACATTCATTA GGCTCTGGTG 180

CTGGAGAAGG ATACGAGCCA ATCAGTGATG ACGAACTAGA TGAAATTCTG GCAGGTGATG 240

CAGAAAAGAG GGAGGACCAA CAGGATGAGG AGAAGATGCC AGATCCCTTA GATGTGATAG 3 00

ATGTGGATTG GTCTGGTCTT ATGCCAAAGC AT CCAAAAGA ACAACGAGGC TCGAG 3 55

(2) INFORMATION FOR SEQ ID NO: 1013:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 51 base pairs

(B) TYPE: nucleic acid

429

WO 98/45437

PCT/US98/06956

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii)

MOLECULE TYPE: cDNA

(xi)

SEQUENCE DESCRIPTION: SEQ ID NO: 1013:

GAATTCGGCC
ATTTGTGGTA
TGCTGAGGGA
GTCATAGAAT
AGTAGAGGCC
AGAATTTAAT

TTCATGGCCT ACAGCCTAAA TGTTTTATTT CCTGAGAGGC TGGAATCTGT
TCAATCAGTC AACTGAAATT TAT T AAATG C CTGCTGTGAG CAAGG CCTAA
TGTAAAGAAG AG TG AG AAGC TAGTCTGGTT GGGGTNATAT GACATGGCAA
GAAGAAGCGT ATTCCTTGTC ATATGAAAGC TGCAGATTAG TGTGGTTCTA
AGGGTCACTG GAGTCTAGGA TTGCAGGGTT GGCTGGCTTC CCAGAGGCTA
TTGGATCTTG AAGATCTGGT CCAATTCCAA CANGACTCGA G

60
120
180
240
30O
351

(2) INFORMATION FOR SEQ ID N0:1014:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 93 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1014:

GAATTCGGCC TTCATGGCCT AGGCCTTGTA TTTTTTCTTA TTTTCTGCTA AATTAGAAAG 6 0

AAATTTGCTG TTTCAAATAT AC T CAAGCTG TTCAGTTCTT CAACAAAAAG TAGGTGACTG 12 0

AAAACTGTAT GTTTAACTAT GCTTAAGTTA ATATTTATAG TAATGATAGA AGCCATTTTA 180

TTGG CAATAT ATCACTTCCT GATTTCCACA CCAGGCATTC CCACATGCAC AAACAGGTGT 24 0

GTGGGAGGAA GGGAAATGGG CAAAAATGAT TTCCTTCAAG AGG CTACTGA GAATGAAAAC 300

TCAAAATCTG CACAAATAGG GGTGGTGGAA GGAGAGAAAG AAAACT CCAT GCCAGAAATA 360

ACATGCTTAG CAGAGAGAGA GAGAGATCTC GAG 3 93

(2) INFORMATION FOR SEQ ID NO: 1015:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 262 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1015:

GAATTCGGCC
GTATTTTTGT
ATATTTGTGC
TTCAGGAATC
AATTTGTACT

TTCATGGCCT AACTCAGTTG GCTTCTAATT TGCGTAACAA GATTAAGGTA
ACTATTATTG GAAGCATGCC TTCCCTTTTT CACATTATTA AATTGTATTT
AATTTTAAAC TATGTTTTCA AATAAACTTT GTCTGCGGCT TCGAGGTCTT
TTTCAAAATG GGATTTGGGG ATCAGAACTC CTTCTGATCA AATGGAATCC
ACTGGTCTCG AG

60
120
180
240
262

(2) INFORMATION FOR SEQ ID NO: 1016:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

430

WO 98/45437 PCT/US98/06956

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1016:

CAGAATGGGA CTCCAAGCCT GNCTCCTAGG GCTCTTTGCC CTCATCCTCT CTGGCAAATG 6 0

CAGTTACAGC CCGGAGCCCG AC CAG CGGAG GACGCTGCCC CCAGGCTGGG TGTCCCTGGG 120

CCGTGCGGAC CCTGAGGAAG AGCTGAGTCT CACCTTTGCC CTGAGACAGC AGAATGTGGA 180

AAGACTCTCG GAGCTGGTGC AGGCTGTGTC GGATCCCAGC TCTCCTCAAT ACGGAAAATA 24 0

CCTGACCCTA GAGAATGTGG CTGATCTGGT GAGGCCATCC CCACTGACCC TCCACACGCT 3 00

CGAG 3 04

(2) INFORMATION FOR SEQ ID NO: 1017:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 55 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION • SEQ ID NO: 1017:

GAATTCGGCC AAAGAGGCCT AGTTTAAAGA AAAAAAAAAA GACCCATCAA GGGCATAGAA 6 0

AAG CTTAGGT GAAGAAACCC TAAAATGAAT CCTCATTTAT CAACTCATTC ATTTATTGAT 120

TCATTTGTTC ATTCATTTGT TCACT CAAGA AGTATTTGTT GCCAGACACA GTACCAACAA 180

AGAAAATAAG CATCCACTAC GGCTTTGCAG AGCTTGGTAC GCAATGCCTG GTTCAGAGGA 240

GATATTTGTT CATCGCTTGC TTTTAACTGT ATCACAGCCT AGGGTGGCAT GCAGAGGTTT 3 00

GAATAAGTGC TGAAACAGGA CAAGTGAGGT GCTTATGGAA ACACACAGGC TCGAG 3 55

(2) INFORMATION FOR SEQ ID NO:1018:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 502 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1018:

GAATTCGGCC AAAGAGGCCT AGAAGGAAAT TGTCCCGAAT CCCTGCAGTC TTTCTGTAGG 6 0

TTGCGGCACA ACGCCAGGCA AAAGAAGAGG AAGGAATTTA ATCCTAATCG GTGGAGGTCG 120

ATTTGAGGGT CTGCTGTAGC AGGTGGCTCC GCTTGAAGCG AGGGAGGAAG TTTCCTCCGA 180

TCAGTAGAGA TTGGAAAGAT TGTTGGGAGT GGCACACCAC TAG GG AAAAG AAGAAGGGGC 24 0

GAACTGCTTG TCTTGAGGAG GTCAACCCCC AGAATCAGCT CTTGTGGCCT TGAAGTGGCT 3 00

GAAGACGATC ACCCTCCACA GGCTTGAGCC CAGTCCCACA GCCTTCCTCC CCCAGCCTGA 360

GTGACTACTC TATTCCTTGG TCCCTGCTAT TGTCGGGGAC GATTGCATGG GCTACGCCAG 42 0

GAAAGTAGGC TGGGTGACCG CAGGCCTGGT GATTGGGGCT GGCGCCTGCT ATTGCATTTA 48 0

TAGACTGACT AGGGGGCTCG AG 502

(2) INFORMATION FOR SEQ ID NO: 1019:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 465 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

431

WO 98/45437

PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(xi> SEQUENCE DESCRIPTION: SEQ ID NO: 1019:

GAATTCGGCC AAAGAGGCCT AATCAAATAG TAAAGGCTGT TCTGGCTTTT TATCTTCTTA 6 0

GCTCATCTTA AATAAGTAGT ACACTTGGAT GCAGTGCGTC TGAAGTGCTA ATCAGTTGTA 120

ACAATAGCAC AAATCGAACT TAGGATTTGT TTCTTCTCTT CTGTGTTTCG ATTTTTGATC 180

AATTCTTTAA TTTTGGAAGC CTATAATACA GTTTTCTATT CTTGGAGATA AAAATTAAAT 24 0

GGATCACTGA TATTTTAGTC ATTCTGCTTC TCATCTAAAT ATTTCCATAT TCTGTATTAG 300

GAGAAAATTA CCCTCCCAGC ACCAGCCCCC CTCTCAAACC CCCAACCCAA AACCAAGCAT 360

TTTGGAATGA GTCTCCTTTA GTTTCAGAGT GTGGATTGTA TAACCCATAT ACTCTTCGAT 420

GTACTTGTTT GGTTTGGTAT TAATTTGACT GTGCACGATC TCGAG 465

(2) INFORMATION FOR SEQ ID NO: 1020:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 24 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1020:

GAATTCGGCC TTCATGGCCT AGGATTTCGT ATGCAAGCTC TTGTTT CTCA GGCTGCCTGC 60

AGAAGAAGTC GCTATAAATT ATCTGTTGTC TACATGGTAC AAGGCCCATT GACTCATCTG 12 0

ATGCTTGTTT TGTTAATTTC TTTAATATTT TTATCACGGG GCAGTGGGAG GGCTTGGGCT 180

TTTAGCCACA GCTGTTTTAA GACTTCTGAT CTCCTGCCCT GCAGGAATAG GTGGCAACTC 240

GAG 243

(2) INFORMATION FOR SEQ ID NO: 1021:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 442 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1021:

CTCCACCGAG AGCCTGGACA GTATGAAGGC TCTGACAGCC GCCATCGAAG CTGCAAACGC 6 0

CCAGATCCAT GGCCCTGCCA GTCAACACAT GGG CAATAAC ACTGCCACCG TCACCACCAC 120

GACTACCATA .GCCACCGTCA CCACGGAGGA CAGGAAGAAG GACCACTTTA AGAAAAATCG 180

ATGCCTGTCT AT CGGG AT AC AGGTGGATGA TGCTGAAGAA CCTGACAAAA CAGGGGAGAA 24 0

TAAAG CACCC AGTAAGTTCC AGTCCGTGGG AGTGCAAGTA GAAGAAGAGA AGTGCTTCCG 300

CAGGTTCACT CGATCCAACA GTGTGACGAC AG CAGTACAG GCCGACCTGG ACTTCCATGA 360

TAATCTGGAA AATTCTCTGG AATCTATAGA GGACAATTCG TGTCCTGGCC C CATGGC CAG 420

ACAGTTCTCC CGCGATCTCG AG 442

(2) INFORMATION FOR SEQ ID NO: 1022:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 274 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

432

WO 98/45437

PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1022:

GAATTCGGCC TTCATGGCCT AGATGATCAG GTTTTTCTGG ATGGAAATGA GGTGTATGTA 60

TGGATCTATG ACCCAGTTCA CTTTAAAACA TTTGTCATGG GATTAATTCT TGTGATTGCA 120

GTAATAGCGG CCACCCTCTT CCCCCTTTGG C C AG CAG AAA TGAGAGTAGG TGTTTATTAC 180

CTCAGTGTGG GTGCAGGCTG TTTTGTAGCC AGTATTCTTC TCCTTGCTGT TGCTCGATGC 24 0

ATTCTATTTC T CAT CATTTG GCTCATAACT CGAG 274

(2) INFORMATION FOR SEQ ID NO:1023:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 196 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

{ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1023:

GAATTCGGCC TTCATGGCCT ACTTTT CCAG AAACCAAGAG TGGCTCTACT GTGGCTATAT 60

TATTATTGTT ATTATTATTA TTTTGGAGAT GGGGTCTCAC TTTGTCATCC AGGCTGGAGA 120

GCAGTGGCAC CATCATAGCT CACTACAGCC CCAAACTGCT GTGCTCAAGG GATCCTCCTG 180

TCTCAGCCTT CTCGAG 196

(2) INFORMATION FOR SEQ ID NO:1024:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 95 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1024:

GAATTCGGCC TTCATGGCCT AATCATTTAT ATAAAGTTTA AAAACATTTC AGAACTGAAC 6 0

TATATATTTT TAGAAATATC TGCATATGCC ACATAAATTT TTAAAAT CAT AAGAATGCTA 120

AACAGCACAT TCAGGACAGG GTGAAGAAAC AGGCATGCAG GTTGTGCAGT AGGAAG CTGG 180

GTAACATTGT TCCTTATGGC TTTGTTGTCG CTTCCAGAAT TTCATTAAAA ACTTTTTAAA 24 0

AAACATGGGC CCACATTATG AATTACGTCT GCTTTTAGAG TACTAAAAAC TCCAAGCAAA 3 00

AACACATGAG CCACCGGGCA CGCCTGGCCT TTATTTTATT TTTCTACGTT ATTATTCCTG 360

TTTTCAGAGG AGGGAATTGT CAGGGAACTC TCGAG 3 95

(2) INFORMATION FOR SEQ ID NO: 1025:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 429 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1025:

433

WO 98/45437 PCT/US98/06956

GGAGAG CTCT GGGCCAGCCC TTCTCTCTCT CTCTCTCTCT CTCTCTCTCT CTCTCTCTCT 6 0

CTCTCTCTCT CTCTCTCTCT CTCTCTCTCT CTCTGTGTGT GTATATATAT ATATATANAC 12 0

TTTTCCCTTC TGGATGCAAT AGAGCTATTT TTTTCTCTTT GGAATTGAGT GACACCACCA 180

AGATACGTTT TTGGGTTGAA TATGTGTGTT TTTCAAAATT CAGTCTGGCC TTTTTTGTTG 24 0

TTGTTGTTGT TGTTTTCTTT AGATGGAGTT TCACTCTTGT TGCCCAGTCT GGAGTGCAAT 3 00

GGCACTATCT CTACTCACTG CTACCTCCGC CTCCCAGGTT CAAGCAATTC TCCTGCCTCA 3 60

GCCTCCCAAG TAGCTGGGAT TATAGG CATG TGCCACCATG CCCAGGCAGT TTTTGTATTT 4 20

AGTCTCGAG 42 9

(2) INFORMATION FOR SEQ ID NO: 102 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 07 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1026:

GAATTCGGCC TTCATGGCCT AGAGAACTGG AGCCAGCTGT CAACTGCCCC CGCCCCACCC 60

AGGCCATTTG GCTTCTGCTA CCGGCATGCT GCTCAGGGCT CTGCCCAAGG ACAACGACGA 12 0

GCCCCCTGTG TCCTCTCCTG GGTCATCTTC CATGACCCTG AGGCAGCGAA GACAAGCTCG 180

GCAGCTCCCT GAGCTG CTT C ACACCAACTA CCTATGAGTC TGAGGCCAGC ATCCAGGCGC 24 0

TGCCCAGACC CTGAGAGTCC CTGGACCATG ACGTAGCCTG TGTGTGAAGG GAG CAAGACA 3 00

GCCTTGACAG AAGCACAGAG AACGCCACTG GGATTCTTAA AGACGCGAAG GGAAAAAGCA 3 60

CAGAAGATGC TGGCGCTGCA TCTCCTCCAG CACCGAGAGG CCTCGAG 4 07

(2) INFORMATION FOR SEQ ID NO: 1027:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 02 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1027:

GAATTCGGCC TTCATGGCCT AAATTAATAT CCTTATTTTT GCAGATTAGG AAACTAAGAC 60

GTACTGAGGC TGGGTGCCTG GTTCAAGATC ATATAGCTAA CATTATTGGA CATGCAAATC 12 0

AAGCCCAGAT TTGTGACTCT GAG CTGATGT TAATTCTGTC ACAATATTGG TTCTCAAGAT 180

AAATCTTTCC AGGTGAGGGG GAAAGGGAAT AAATATCTAG AAGTCCCCTT AAACAGAAGT 24 0

AATTAATTCG TTTGCAGAAA TTGG CAAAAT TTGGGGTTCC CTTCTTAAAA GTTTCCTTCT 3 00

GTCACTTGGA AAAAATTTAA AATATGTGCA TTAGGTTGAC AAAGATCAAA AAAGTTAAAA 3 60

AAAAACCCTT TTTGGAATGC TGTGGAGAAA GTAGCACTCG AG 4 02

(2) INFORMATION FOR SEQ ID NO: 102 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 320 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 102 8:

434

WO 98/45437

PCT/US98/06956

GAATTCGGCC TTCATGGCCT AAGGGGCTGA AATTAAGAAT GTGGCTTTTT TATCCTTTCA 6 0

AAAATAGATT ATTTGGCTGG ATGTGGTGGC TCACGCCTGT AATC CTAGCA TTTTGGGAGG 12 0

CTGAGGCAGG CAGATCACCT GAGGTAAGGA GTTCAAGACA AG CATGTCCT GGTGAAACCC 18 0

CATCTCTACT AAAAATACAA AAAATTAGCC AGGTGTGGTG GCAGGTTCCT GTAGTCCCAG 24 0

CTACATGGGA GGCTGAGGCA GGAGACTCAC TTGAACCCGG AGTGTCTCGA GGCAGGTCTA 3 00

GAATTCAATT AGGCCATGAA 320

(2) INFORMATION FOR SEQ ID NO: 102 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 252 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1029:

GCAGATTTTC GCTCTCATCC CATATCTATT GAGAATG CTG TAGTTGAGGG TTGTTAGAAA 60

CCTGCATTTT ATTAAAATCC CTCCAGGTGA TTCTGATGCA GGCTAGTTCA GTAAACAATA 120

TCAACTAGTT TTCATAAAGA AAACCTCTGG AGGGCCCATA GTGCCTGCAC TCCAGGTCTC 180

AAAGTATACT TTGAGATCTA GGTTATCTGC CAAGGTG CTA TCCTGAAAGG ACTCTAAATG 240

AGACAACTCG AG 252

(2) INFORMATION FOR SEQ ID NO: 1030:

(i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 103 0:

GAATTCGGCC TTCATGGCCT ACCTTATGGC CTAATTAAAT ATTAGTAATA GG TATTCG AT 60

TTGTTTTTAA ATGATTTCTT GTAATAGACT ATTGGGTCAG CTAATACTTT TTTGCATCTT 120

CATATTTTAT GTCATGTTAA TGATAAATTT TCTGACTTTG ATTTGTATGT TTTTGCCCTT 180

TATCCTCTTA GGTGG CCTTG GGGGACTTGC AGGTCTGAGT AGCTTGGGTT TGAATACTAC 240

CAACTTCTCT GAACTACAGA GTCAGATGCA GCATCTCGAG 280

(2) INFORMATION FOR SEQ ID NO: 1031:

(i) ' SEQUENCE CHARACTERISTICS:

(A) LENGTH: 291 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1031:

GAATTCGGCC TTCATGGCCT AGAGCAAGTG GTTTTTAAAT ATCTTCGAGC TGAACCTGAG 60

GACCATTATT TTTTAATGAC AGAACCTCCA CTCAATACAC CAGAAAACAG AGAGTATCTT 12 0

GCAGAAATTA TGTTTGAATC ATTTAACGTA CCAGGACTCT ACATTGCAGT TCAGGCAGTG 18 0

435

WO 98/45437

PCT/US98/06956

CTGGCCTTGG CGG CAT CTTG GACATCT CGA CAAGTGGGTG AACGTACGTT AACGGGGATA 24 0

GTCATTGACA GCGGAGATGG AGTCACCCAT GTTATCCCAG TGGCTCTCGA G 291

(2) INFORMATION FOR SEQ ID NO: 1032:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 277 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1032:

TAAAATAATT TAACTTTTTT ATTACAT TAA AAAACAGGAC TCTGGGAATT GTCACTTTAT
GATCAGCCTT ATATTTTTTC CAGACTGTGT CATTGTGTAT GCCTGTGCCA CCCAACGGAT
GAGACCACTG ATCATGTTTA GCTCAAATTT ATGTTGGATA GAGGTTATAG GATGGTCCTT
ATCTGAATGC AGAAAGGAAT GTTTATTTTG CTGTTATGTT TTATATGGGA TAATACTTTA
TAATTGTGTG ACTATCCTAT TCCCCAACAA ACTCGAG

(2) INFORMATION FOR SEQ ID NO:1033:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 298 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1033:

GAATTCGGCC TTCATGGCCT AGGTTACATG TATAAAATAA TCGTAGCTGT TAAT CAAACT 60

GATCATTTGC TATTTGTTGT TTCACATGTT TTCATTTATT TGTTCATTCA GCAAACACTT 120

AGTTGTGTGC CAGGAATTAA AATCCAGTGT TGTTCTTTTC TTATTTTTTT TTTGG CTAGT 180

GGAAAATGAA AACCACTGTG ACTTTGTAAA GCTGCGGGAA ATGCTCATTT GTACAAATAT 240

GGAGGACCTG CGAGAGCAGA CCCATACCAG G CACTATG AG CTTTACAGGC ATCTCGAG 2 98

(2) INFORMATION FOR SEQ ID NO:1034:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1034:

60
120
180
240
277

GAATTCTGGA AGACACTGAC TGACTGGAAG ACCTGGATTT CTTTCTGGAA GACACTGATT 60

GACTGGAAGA CCTGGATTTC TTTCTGGAAG ACACTGATTG AC TGG AAGAT CTAGATTTTT 120

CTGGAAGAAC TAGATTTACT GGAAGACTTG GATTTGGTGG AAGACGTAGA TTTTTCTGGA 180

AGACACTGAC TGACTGGAAG ACCTGGATTT CTTTCTGGAA GACACTGATT GACTGGAAGA 24 0

CCTGGATTTC TTTCTGGAAG ACACTGATTG ACTGGAAGAT CTAGATTTTT CTGGAAGAAC 3 00

TAGATTTACT GGAAGACTTG GTAGGCCATG AAGGTCGAG 33 9

(2) INFORMATION FOR SEQ ID NO: 103 5:

436

WO 98/45437

PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 263 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1035:

GAATTCGGCC AAAGAGGCCT AGCACTGTAA AGATGAAGCT GGCTAACTGG TACTGGCTGA 6 0

GCTCAGCTGT TCTTGCCACT TACGGTTTTT TGGTTGTGGC AAACAATGAA ACAGAGGAAA 12 0

TTAAAGATGA AAGAGCAAAG GATGTCTGCC CAGTGAGACT AGAAAGCAGA GGGAAATGCG 180

AAGAGGCAGG GGAGTGCCCC TACCAGGTAA GCCTGCCCCC CTTGACTATT CAGCTCCCGA 24 0

AGCAATTCAG CAGAGATCTC GAG 263

(2) INFORMATION FOR SEQ ID NO: 103 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 262 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1036:

GAATTCGGCC AAAGAGGCCT AAAGCACCCG CTTCCTCACC ACCCCCACTG TTGGGCCTAT 6 0

AGTAGCAGGT TAGTGAGTAC CTAGGGCGGC TCAACTCCTC CCACAGCACC AACCCAGCAT 120

GGTCCCACTG AAGTCCTACT ACGCCCTCCC CTCCCCAGCC TTTTCCAGAA ACCATAC TGG 180

GCTCAGATCA GAGCTCCGAA GCGGTCAAAG TGAGCTGAGC AGGACAGGCC CAGCCTTTCT 240

CCACTGCCAC GTCACCCTCG AG 262

(2) INFORMATION FOR SEQ ID NO: 1037:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28S base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10 37:

. GAATTCGGCC AAAGAGGCCT ACGGAGCTGT CAGCCAGGGG AGTGGGGTCA GCCGTCAGCC 60

AGCCCTCCCG TTTCCCGCCC GTGGGCCCTG ACCACACTCC CTTTTCTAGA AGTCAATCCT 120

AAGGTTTCTC TGCTCTGGCT AAGAGGATGT AAATTTGGAT TCTTAGAGGG CATGGCACCC 180

CCAGTCCCTG CCCAGATAAA GTAG CACAGT GGCATGCAGC ACCTCTGTCT GTTGCTGACG 24 0

TTGGGGGGCT TACACACCCA CCTCATCTCC GTGCACAGAC TCGAG 285

(2) INFORMATION FOR SEQ ID NO: 103 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

437

WO 98/45437

PCT/US98/06956

(ii.) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION ; SEQ ID NO: 1038:

GAATTCGGCC TTCATGGCCT AGCTCTGCAA GGAAGAGAGC TTCACGTCTC TGGTCAGCCA 6 0

AGCGAGGCTG TCTCTCCAGC TCTCAGAGAG CTCTCGGGGC TCTCCTGCAG GAGACCAGGC 12 0

CAATGCTCCT GTGCTTCCTG GGGCCAGTAG CAGCACCCTG AGCTCCCTGC CACCAGGCAG 180

CTGAAAGGCA TAGCGTGAGG TGCTTCTCTC AGTCCCAATT ATGACAGTGG CCACCGGAGA 24 0

CCCAGCAGAC GAGGCTGCTG CCCTCCCTGG GCACCCACAG GACGCCTCGA G 2 91

(2) INFORMATION FOR SEQ ID NO: 103 9:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH; 3 93 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 103 9:

GAATTCGGCC TTCATGGCCT AACTCTACAG CAGTGCTTAT TTTTACATTT CCAAGCGAAT 60

ACCAAAACCT TCAGCAAAGA TTGGGTTGGT ATTAACGGGT TTTTGTCTCA GAACTGTATT 12 0

GTGGATCCCG GAGTTTCCCC CAAATCCATC TACATCAAAT TTGTAGAAGT AGAGAGGGAT 18 0

TTTCTTTCCG CAGGCTCTTT AGTTGAGTGC CTGGAAAAAG CCATTGGATA CCCCTTAAAA 24 0

TTTAACAACT GAATGTCATC CTTCATAAGG ATTTGGGCTC TTAGCTCCTT CTTCTCTACT 3 00

CACTTCCCAT TACCCGGACC ACCCCTCATC CAGATGCCGC CGTCAGACTC TT CATGG AAA 360

CCCTTTCTTC AATTGGGCCA GTACGAT CTC GAG 3 93

(2) INFORMATION FOR SEQ ID NO: 104 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 03 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1040:

GAATTCGGCC AAAGAGGCCT ACCCTACTGT GACACACCTA CCATGCGGAC ACTCTTCAAC 60

CTCCTCTGGC TTGCCCTGGC CTGCAGCCCT GTTCACACTA CCCTGTCAAA GTCAGATGCC 120

AAAAAAGCCG CCTCAAAGAC GCTGCTGGAG AAGAGTCAGT TTTCAGATAA GCCGGTGCAA 18 0

GACCGGGGTT TGGTGGTGAC GGACCTCAAA GCTGAGAGTG TGGTTCTTGA GCATCGCAGC 24 0

TACTGCTCGG CAAAGGCCCG GGACAGACAC TTTGCTGGGG ATGTACTGGG CTATGTCACT 3 00

CCATGGAACA GCCATGGCTA CGATGTCACC AAGGTCTTTG GGAGCAAGTT CACACAGATC 360

TCACCCGTCT GGCTGCAGCT GAAGAGACGT GGCCGTGAGA TGTTTGAGGT CACGGGCCTC 420

CACGACGTGG ACCAAGGGTG GATGCGAGCT GTCAGGAAGC ATGCCAAGGG C CTG CACATA 480

GTGCCTCGGC TCCTGTTTGA GGACTGGACT TACGATGATT TCCGGAACGT CTTAGACAGT 54 0

GAGGATGAGA TAGAGGAGCT GAGCAAGACC GTGGTCCAGG TGGCAAAGAA CCAGCATCTC 600

GAG 603

(2) INFORMATION FOR SEQ ID NO: 1041:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid

438

WO 98/45437

PCT/US98/06956

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1041:

GAATTCGGCC TTCATGGCCT ATAGAAACAT CAGTGGGCAC ATTTACAACC AGAATGTATC 6 0

CCAGAAGGAC TGCAACTGCC TGCACGTGGT GGAGCCCATG CCAGTGCCTG GCCATGACGT 120

GGAGGCCTAC TGCCTGCTGT GCGAGTGCAG GTACGAGGAG CGCAGCACCA CCACCATCAA 180

GGTCATCATT GTCATCTACC TGTCCGTGGT GGGTGCCCTG TTGCTCTACA TGGCCTTCCT 240

GATGCTGGTG GACCCTCTGA TCCGAAAGCC GGATGCACAC ACTGAGCTCG AG 2 92

(2) INFORMATION FOR SEQ ID NO: 1042:

(2) INFORMATION FOR SEQ ID NO: 1043:

60
120
180
240
300
331

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 31 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1042:

GAAGAAAAGC AGAAAGAACT GGCAGAAACA GAACCCAAAT TCAACAGTGT GAAAGAGAAA
GAAGAACGAG GAATTGCTAG ATTGGCTCAA GCTACCCAGG AAAGAACGGA TCTTTATGCA
AAGCAGGGTC GAGGAAGCCA GTTTACATCA AAAGAAGAAA GGGATAAGTG GATTAAAAAG
GAACTCAAGT CT TTAGATCA GGCTATTAAT GACAAGAAAA GACAGATTGC TGCTATACAT
AAGGATTTGG AAGACACTGA AGCAAATAAA GAGAAAAATC TGGAGCAGTA TAATAAACTG
GACCAGGATC TTAATGAAGT CAAAGCTCGA G

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 268 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1043:

GATGGCCACT TCCCAGGCTG ACATAGAGAC CGACCCAGGT ATCTCTGAAC CTGACGGTGC
AACTG CACAG ACATCAG CAG ATGGTTCCCA GGCTCAGAAT CTGGAGTCCC GGACAATAAT
TCGGGGCAAG AGGACCCGCA AGATTAATAA CTTGAATGTT GAAGAGAACA G CAGTGGGG A
TCAGAGGCGG GCCCCACTGG CTGCAGGGAC CTGGAGGTCT GCACCAGTTC CAGTGACCAC
TCAGAACCCA CCTGACGCAC CCCTCGAG

(2) INFORMATION FOR SEQ ID NO: 1044:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

439

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PCIYTJS98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1044:

GTCATTGCAT CCAAGATAAT GAAATATCTA TAACCCCAAA AGTTTCCTGT GTGCCCTTGT 60

TATTCATTGC CCTGCCCAGT ATTCAGGCAA CACGGATCTG TTTTCTGTTT TAGGTTAGTT 120

TGCATTTTCT ATAAAGTCTT ATGAATGAAA TAATAAAATG TGGACTATTT TCATGG GCCG 180

GGGAGCAGTG TGGCTTCTTT CATTTCAAAT GATTGTTTTG AAATTCATCC ACAGCGTTGC 24 0

ACGTATCAGT AGTAGATTCC ATTTGATTGT TGATTTGTAT TCTATTGTAT G CCTGAGTCA 3 00

AAATTTATTC ATCTCTTTGT CTGTTGATAG CCATTTGGGT TCTTCCAGTT TGGGGCCATT 360

ACAAATAGAG GTACTATGAA CTTTTCTCGA G 3 91

(2) INFORMATION FOR SEQ ID NO: 104 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 288 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
<D) TOPOLOGY: linear

<ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 104 5:

GAATTCGGCC TTCATGGCCT AATGTGAGCC ACCGCACCCA GCCGAATATT TGTACTTTGT 60

ATAAATTCAT TGTCTGTTTT ACAGTTTGAA TGGCTCTTTT ACCCTGGCAT AATTTTGTAA 120

CGTGTGGAGC ATTTGGAAAA TTTTTATTGG ATTATG CAGA TATTTTCAAT GCTGGTATTT 18 0

CATTATATGA TAGTAAAAAA TCACTTTTTG TTTTGTTTTG TTTTGTTTAT TTTTCTTTTT 240

TTTTTGAGGC AGAGTTTCGT GCTTGTCGCC CAGCCGAAGG CGCTCGAG 2 88

(2) INFORMATION FOR SEQ ID NO: 1046:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 279 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 104 6:

GAATTCGGCC TTCATGGCCT AGTAACTTCA TAACATTGCT GGTGTTGAGG TGAATCTTAG 60

TGGTCATCCA GTCCCAAGGC ATCCTTG CCA GCCCCCTACA ATACCTGGAT GGGCGCTTAT 12 0

CTTCAGGTAG GCCTGAGCCT TTCTGGTAAA GAGGAGCTCA CTATTTCTAA AGGAAACCTG 18 0

TGCCATTGGG TTAAAAAAGT ATTAATTTTT AAACATTGGT AGTTGTTAAG CAGT TGTTG A 24 0

ATATTTTGAG CCAAAATTTG TTACCTCCCA TACCTCGAG 279

(2) INFORMATION FOR SEQ ID NO: 1047:

U) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 350 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 1047:

440

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PCT/US98/06956

GAATTCGGCC TTCATGGCCT AGCAGCATTC AAGGAATTAA TATTAGTCAC TGAGAACAAA 6 0

AAGCGAAATT AGAAAATTTC AAGTCACTTC TAGG CTTGTA GGGGAGAAGA CGTGTAGTGA 12 0

TGAATTCTAT CATTTATGAA GTACCCACTG GATCCCACAC ACTGTGCAAG ACCTTTAGAT 180

CAGGCGCCTC CCTCGGTTTT CTTCACCCTG TGCAGCAGGT GCTGTTATTT CCTTTTTTAA 24 0

ATTATTATTT ATTATTATTA TTTTTTGAGA CAGGATCTCC CTTTGTCACT CAGGCTGGAA 3 00

TGCAGAGGCA TGATCACTGC TCACTGCAGC TTCGACCACC CGATCTCGAG 3 50

(2) INFORMATION FOR SEQ ID NO: 1048:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 29B base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 104 8:

GAATTCGGCC TTCATGGCCT AAAGCTTTTC AGTACTGTTT ACAAATTTGG TTTTATTGTG 60

TCAACTTAAA AGCATGAGTC TAAATCTATT AGTCATACCA AATTGTTTCA TTTTATTTTA 12 0

TTTTATAGAG ATGGGGTCTT GCTGTATTGC CCAGGCTGGT CTCAAACGAC TAG G CTCAAG 180

CGATCCTCCC ACCTCAACCT CCCAAAGTGC TGGGATTACA GGTGTAAGCC ACCATACACA 24 0

GTTCTCAAAT TATTTTATAC AATACAAACA TTTAAAATAT AAATCATGCA CTCTCGAG 298

(2) INFORMATION FOR SEQ ID NO: 104 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 367 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 104 9:

GAATTCGGCC TTCATGGCCT AGAGCTTTGG TGCTTTTCAC ATAAGGAACT TACTTGGGCT
AAAAAGTAAC CTCAGAGAAA CAGTGCTCCC AT TTGGTGG A TAAGGAAACT GAGGTTCCAA
ACATGAGATG TAATAGCTTG CCCCAAATCT AG CCAGTG AG CAAGAGAGTA GACTTTTGCC
TGTGCCAAAA CAGTAATCAC CAT CCACAAG TGGCTATTTA AATTTTAATT ATTACAATTA
AATAAAGTTT AAAATCCAGT TCCCCAGTCC CACTGGCAAC TTAACAG CTA CCAGTGACTG
TACCATATAT AACAGCATAT ATAGACATAC AG CATAT AC A ACACATACAT AGGGATTCCC
ACTCGAG

(2) INFORMATION FOR SEQ ID NO: 1050:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 367 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1050:

GAATTCGGCC TTCATGGCCT ACAATTTTAA AATTAAAATT TTTTCTATTT TTTTGCAATT 60
ATCAACCTAA CACATTGAAG AAACTTGGGA AATATAGAAA AAACACACCA AAAAGTATCA 120

60
120
180
24 0
300
360
367

441

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PCT/US98/06956

GAGTTACACT AAAATGTTCA TAGTCAGTAA TAT AG TCTTT CAGATTTTTT TTTCTGTGTC 180

TGTCTGCTGT CTATGTCCAT GCCTACCTTA CTTTCTTCCC TCTCTCTTCC CTCCCCACCC 24 0

TCCCTTCCTT CCTTCCCTCC TTCCCACCTT CCCTGCTTCC TTCTTGCCTG CCTCCCTTCC 3 00

TGCCTGCCTC CCTTCCTGCC ACTTACATTC TGTTAACAAT GAGAAAAAAA TTCCCCCATC 3 60

ACTCGAG 3 67

(2) INFORMATION FOR SEQ ID NO: 1051:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO: 1051:

GAATTCGGCC AAAGAGGCCT AAGAAG AC CT CAGCCTTCGC CTGAAAAAGC TGACTCACGC 60

TGCCCCCTGC ATGCTGTTCA TGAAGGGAAC ACCTCAAGAA CCACGCTGTG GTTTCAGCAA 120

GCAGATGGTG GAAATCCTTC ACAAACACAA TATTCAGTTC AGCAGCTTTG ATATCTTCTC 180

AGATGAAGAA GTTCGACAGG GGCTCAAAAC GTACTCTAAT TGGCCCACCT ATCCTCAGCT 240

CTATGTTTCT GGAGAGCTAA TAGGAGGACT TGACATAATT AAGGAGCTGG AAG CAT CAG A 3 00

AGAG CTGGAC ACGATCTGTC CCAAAGCACC CAATCTCGAG 34 0

(2) INFORMATION FOR SEQ ID NO: 1052:

(i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1052:

GAATTCGGCC TTCATGGCCT ACTATGGACA GCCACAGNTC TTCCCAGGAC AAG AC CCTGA 60

CTCACCCCAG CATGGAAACT AC CAGGGAGG GAGGGTCCCC CATCCTACTA TGACAACCAG 120

GACTTCCCTG CCACCAACTG GGATGACAAG AGCATCCGAC AGGCCTTCAT CCG CAAGGTG 180

TTCCTAGTGC TGACCTTGCA GCTGTCGGTG ACCCTGTCCA CGGTGTC TGT GTTCACTTTT 240

GTTGCGGAGG TGAAGGG CTT TGTCCGGGAG AATGT CTGGA CCTACTATGT CTCCTATGCT 3 00

GTCTTCTTCA TCTCTCTCAT CGTCCTCAGC TGTTGTGG GG ACTTCCGGCG AAAGCACCCC 3 60

TGGAACCTTG TTGCACTGTC GGTCCTGACC GCCAGCCTGT CGTACAT^GT GGGGATGATC 420

GCCAGCTTCA ACAACACACT CGAG 444

(2) INFORMATION FOR SEQ ID NO:1053:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 58 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1053:

GAATTCGGCC AAAGAGGCCT AG ATATT CAT TTCCATTGGA GCTGGTATTT TTAAGGTCTC 6 0

442

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PCT/US98/06956

GTGACGTCAG TGACCTCATT TTACTTGATC TATTAGCAGC ATTTCATACA GTTGTTGACT 12 0

CTTCTCCATT AAAACATTTA CTTTATTTGG CTTCTAGGAA ACATATTTTC CTGCTTTTTC 18 0

TTCCTATTTC TCTGACTCTT TTCTCAGTTT CCTTTGCTGT TTCCTTTTCT ATCCTCTAAA 24 0

CATTGAAATA TCCTAAGCCT AGTTTGGGAT TCCCTTGATG GTCTTCATTT CTTTAATGGG 3 00

AACTGTGCTG GTGACTCAAA TTTATATCTC CAGCCAGAAC CTTTCTCCTG AATTCCAG 3 58

(2) INFORMATION FOR SEQ ID NO:1054:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 86 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1054;

CCTTCATGGC CTACTTCTGG TATTACATCA CACTGATCAT GCTGCTGGTG GCCGTGCTGG 6 0

CCGGAGCTCT CCAGCTGACG CAG AG CAGGG TTCTGTGCTG TCTTCCATGC AAAGTGGAAT 120

TTGACAATCA CTGTGCCGTG CCTTGGGACA TCCTGAAAGC CAGCATGAAC ACATCCTCTA 180

ATCCTGGGAC ACCGCTTCCG CTCCCCCTCC GAATTCAGAA TGACCTCCAC CGACAGCAGT 24 0

ACTCCTATAT TGATGCCGTC TGTTACGAGA AACAGCTCCA TTGGTTTGCA AAGTTTTTCC 30 0

CCTATCTGGT GCTCTTGCAC ACGCTCATCT TTGCAGCCTG CAG CAACTTT TGG CTTCACT 360

ACCCCAGTAC CAGTTCCAGG CTCGAG 3 86

(2) INFORMATION FOR SEQ ID NO:1055:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 104 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1055:

CGATTGAATT CTAGACCTGC CTGTGCTCCT CGATGGTGTC TCTCCCTCCA G AAAACG CAT 6 0

GCTTATTGAC CTTGGTTTTG ATCTGCTTGG CCGTGTCGCT CGAG 104

(2) INFORMATION FOR SEQ ID NO: 1056:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 650 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(XX ) SEQUENCE DESCRIPTION: SEQ ID NO: 1056:

GAATTCGGCC AAAGAGGCCT ACACAAGGCT AAGGGTATTG GATATAACGG AAAGTGGAAG 60

CTATACCTGA CTTCCAGAGA ATGTGGACCG GATATAAGAT CTTAATCTTC TCTTATCTTA 12 0

CTACAGAAAT CTGGATGGAG AAG CAGTATT TAT CTCAAAG AGAAGTGGAC CTAGAGGCTT 180

ATTTCACTAG GAATCACACC GTTTTGCAAG GTACTCGATT CAAAAG AG CC ATTTTCCAAG 24 0

GGCAATACTG TAGAAATTTT GGCTGTTGTG AAGACAGAGA TGATGGCTGT GTCACTGAGT 3 00

TCTATGCGGC GAATGCGTTG TGCTACTGTG ATAAATTCTG TGACAGAGAA AATTCTGATT 360

443

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PCT/US98/06956

GCTGTCCTGA CTACAAGTCC TTTTGCCGTG AAGAGAAAGA ATGGCCTCCT CACACACAGC 4 20

CTTGGTATCC AGAAGGTTGC TTCAAAGATG GTCAACATTA TGAAGAGGGA TCAGTAATTA 4 80

AAGAAAACTG CAACTCCTGC ACATGCTCAG GACAGCAATG GAAATGTTCC CAGCATGTAT 54 0

GCCTTGTTCG TCCAGAATTA ATTGAACAGG TCAATAAAGG AGACTATGGA TGGACAGCAC 600

AGAATTACAG CCAATTTTGG GGAATGACTT TAGAAGATGG ACTCCTCGAG 650

(2) INFORMATION FOR SEQ ID NO: 1057:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 378 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1057:

GAATTCGGCC AAAGAGGCCT ACACGTATTG GCCAGGATGG TCTTGATCTC CTGACCTCAT 60

GATCCGCCGG CCTTGGCCTC CCAAAGTGCT AGGATTACAG GCGTGAGCCA TCGCGCCCAG 120

CTGAGAATAG TTTTAAGAAT TGGTTGAGAG GCAGTTGCTT TTTCTTTGAA TATC TAG AAC 180

TGTTCTGGAC TAACGTCAAA GAAACACCAT GG CAACATTA AAGGGAAGAT TATTTGAGAG 24 0

GCGGGGGATA G TATGG CTTA GGACTTGGGC TGCTACCTTT GACTTTGTAA TTCAAAAGAT 3 00

TGTAATGTTC CATATTTTCA AT CTGATCAT TAAAAATATC TGTGTTACAT GCAAAAAAAA 360

ACCTATAGGC AACTCGAG 3 78

(2) INFORMATION FOR SEQ ID NO: 1058:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 59 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1058:

GAATTCGGCC TTCATGGCCT AATTTTAACA TTTACATAGA CAATTCATTT GGTGTTTTGT 6 0

CTCCTAGTTA TTTGGCCCAA TCTCTGATGA TTTCCACTCT GTCTTGGCCA CTCACTCCGT 120

TTGTCATATC TTGGCCATTA TCATCACCTC AAATTGCTCC ATCTTCAAAA TACTTGCATC 180

TTATTTATTG ACCATATTCC TTCCACTTGG TTTATTGAAC TATTCCCTCT ATCATTCTCT 24 0

GATTTCACTG CAGCCAATG 259

(2) INFORMATION FOR SEQ ID NO: 1059:

(i) * SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1059:

GAAAAAAACT ACTAACCACT GCAAGCTCTT GTCAAATTTT AGTTTAATTG GCATTGCTTG 60
TTTTTTGAAA CTGAAATTAC ATGAGTTTCA TTTTTTCTTT GAATTTATAG GGTTTAGATT 120
TCTGAAAGCA GCATGAATAT ATCACCTAAC AT CCTGACAA TAAATTCCAT CCGTTGTTTT 180

444

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TTTTGTTTGT TTGTTTTTTC TTTTCCTTTA AGTAAGCTCT TTATTCATCT TATGGTGCAG 24 0

CTCGAG 24 6

(2) INFORMATION FOR SEQ ID NO: 106 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 103 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1060:

GAATTCGGCC TTCATGGCCT ACGAGAGTAT ATTGGTAGGG CTGGAATTTC TGG TTCAT AT 6 0

GGTAACTAAC TCTATGTTGA ACATTTTGAG GAGCCCTCTC GAG 103

(2) INFORMATION FOR SEQ ID NO: 1061:

(i) SEQUENCE CHARACTERISTICS:

(A) ' LENGTH: 3 61 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1061:

GAATTCGGCC TTCATGGCCT AAAAGG TTAG GCAATCACTG GGAC CCGCAT GGTGTTCCTC 6 0

CAAAGAATAG GGTAAAGGAG AG CTGGGAGG GAGCCCTCTC CGTTGGGTGA CTCTTGTGTG 120

CCCTTTAGAC AGGCTGGCCT GCCGGTTCCA CAGGGTACAG TTAGGACTTG AGTCTTTCTT 180

TTTCTGTTTT GAGTTGGTGA GTGAGTGATA GGGTAACATG GGCCTTCAGG ATGACCCCTT 24 0

GGAACTGTGC CGAGTTC CTT AAATCTCAGC TGGGATCCTG GACCTGGGAG GCCCCTGTGA 3 00

GGGCCAGCTC TGGAAAAAC C TGGGAGTTGA TGCCGGAGGC TGTGGAAGAA CTCTGCTCGA 36 0

G 361

(2) INFORMATION FOR SEQ ID NO: 1062:

(2) INFORMATION FOR SEQ ID NO: 1063:
(i) SEQUENCE CHARACTERISTICS:

60
12 0
180
240
292

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1062:

GAATTCGGCC TTCATGGCCT AAGAAAAATT GGGAACAAGC TAAGTGCCCA CATAGTTACA
AAAATTACGT TAAATAGATA CACGGTTGCT TTTAAGCTCC ACATACAGCA CCATAGAGCT
TTTTATATAT TTGTAGGCAT TAAAGCAATT CCAGGAAGGA TCTAAACCAA ACACTTGACC
CAGGTTGTCT CTCTGGGGAG TGGAGCCACA TGGGATTTCA CTGTTTCTGT ATTCTTATTA
CTTATATTAA AACACACATG AACAGAAGAA AAAATAGCCC CAGTATCTCG AG

445

WO 98/45437

PCT/US98/06956

(A) LENGTH: 331 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1063:

GAATTCGGCC TTCATGGCCT ACCGTTGTTA CACTTCTGGA CACAAGTTGG GCCGAAGTAA 6 0

GCCAAGCCCA GTCCTTCCTG TTTCCTTTCT CAGGAAATGT GACCACGTGC ACTGGGAAGC 12 0

TTTGTGTAAA GTAGATAGGG GTATG AG CC A ATTGCCCAGC ATTGGTGTTT TGTTTTTTGT 180

TTGTTTGTTT GTTTTCACAG AGTCTTGCCC TGTCACCCAG GCTGGAATGC AATGGCGTGA 24 0

TCTCAGCTTA CTGCAACCTC TGCCTCCCAG GTTCACACAA TTCACCTGCC TCAGCCGCCT 3 00

GAGTAGCTGT GATTACGGGC ACCGTCTCGA G 331

(2) INFORMATION FOR SEQ ID NO: 1064:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 136 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1064:

CGAGTGTTAC ATTCGTTCTT CCGCTCAAAT CCTGATCTGG TCCATTAAAG AGTGTTCGCA 60
GACAAAGTTT CTGAAAGATT AGAGAAGAAT CCCCCAAGAA TCAATTACAA CCAAAATGGA 120
AAGGGACAAC CTCGAG 13 6

(2) INFORMATION FOR SEQ ID NO:106S:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 255 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

( D ) TOPOLOGY : 1 inea r

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 106 5:

GAATTCGGCC TTCATGGCCT AGAATAAAGG AAAATT CAGG T CAT AG ATTG AGTG CTATAT 60

TTGAAGTAAA TACAGACCTT CAAAAAAATA TAATATCAAA AATCACTGCT GAGCTCTCCT 120

GGCCTTCCAT ACTTAGCTCA CCCCGGCACT TGAAATTTCC ACTTACTAAT ACAAACTGCT 180

CCTCAGAAGA AGAGATTACT TTAGAAAATC CTGCAGATGT TCCTGTCTAT GTTCAGTTTA 24 0

TTCCTCTGGC TCGAG 255

(2) INFORMATION FOR SEQ ID NO: 1066:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 379 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

446

WO 98/45437

PCT/US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1066:

GAATTCGGCC TTCATGGCCT ACAACCTGCT TTCCACCTTC TGTAATCTCC CATCAG TG AT 6 0

AAATTACCCA TCAGCTTTCC AGATTCCAGA ATTTTGCTGA CATCTCCTGT TGGCTATGTT 12 0

CTTATTTCCT TTTCTGTTTA TTCCTGTGAC CTTGTGCCCT TTAATTCTTT CCCATAATTT 180

GTTGGGACTT CAGAAGGAAG TGGAGCTAAA GGCATGTGTC TGCCTGCCCC ATCTTGGCTG 24 0

GAAGTTGGGA AGGCCTTCCT TCCAAGG CAC CCAGCATAGC ACCTGGCACA TGATGGATGC 3 00

TCAGCAAATG TCTGTGGGTC TTCTTTTTAC TAAACAGGCA GTTGATTTCA CCAGAAGTAG 3 60

TGACCACCTA AGTCTCGAG 3 79

(2) INFORMATION FOR SEQ ID NO: 1067:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 316 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1067:

GAATTCGGCC TTCATGGCCT AACACAGCTC ACATCAGAAT ATAATAGTGG AACTAGGGTG 60

ACTTCACTCC CTTTCACCTG ATGT CTATCT TGGCCTTTTA GCACCTTGAC TATCCCTGAA 120

AAGACTGGGT CTTTGTTTTC CCAGGGAAAA AACGAAGTGA TGTAGATCTA AG AAATAG TG 180

CCTCTTTAAT ATTTAATTCT TACATGACAA CTAACACACA GGGAAAAGGC TATGTTAAGT 24 0

TGATTATAGC TCCTCTTAAA ATGTCCTATG CTGTCAGTTG GTCTTAGAGA CATGGGAATA 3 00

ACCAAGCAAT CTCGAG 316

(2) INFORMATION FOR SEQ ID NO: 1068:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 99 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1068:

GCGATTGAAT TCTAGACCTC ACCTCTGATC TATCTCTTTT ACCTCAGCAA TTTATTTCCC 6 0

AATTATTATA TCTACTTTAT TGTTCTTATG AGACAATAGA CTATGATAAT TTTCCAGAAA 120

TAATTTTGTT TTCTTCCTCC CATCTTCTAA TGTTGAGACC GTTTCTCTGT TTTCTTTCAT 1B0

CTCTACCCCT CAGTCTCATA GGTTTATTTC TCATTTCCAA TCCAGCGATT TCAAAACCTG 24 0

TACAACAAAC ■ CAACTCAGCA GCCCTTGGCA ACTTGAGGAG ATTTCACAAA CCACTCGAG 2 99

(2) INFORMATION FOR SEQ ID NO: 1069:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 56 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1069:

447

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PCT/US98/06956

GAATTCGGCC TTCATGGCCT ACCATTTCCA CAACCATTTT AATCTGCGCA TCGGTCCCAG 6 0

ACGTAGGGAT TCCTCGTCTC ATCTTGGAAA CATTGCCAGC AGTGGTTCTG ATTTGGAAGC 120

CTGCGTCTGT CACGTGACAC CGTCTGAGCC TGTGCCTGCC TCTCTTTCTT CCGGCAGTGC 180

CCTGTACTCT GTGGGGATGA CGGCAGTGGG CCTGGCCATC CTGTGGTATG TTTTCCGTCT 24 0

GGCCGGGAGA CTCGAG 256

(2) INFORMATION FOR SEQ ID NO: 1070:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 321 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1070:

GAATTCGGCC TTCATGGCCT AG CCATCATG TTTATTAGAA GGTTGGATTT TGGTGTGTGC 60

TCTAGACAGA TACAGAATAA ATACCTGCGC CTTGAGAACA GGAAGTCCAC GATTCATACA 120

AAGTGCTCAC TACAGGAAGT TGCTGTGTCA AAAT CCAGG C AAGGACCCAA CTCCGGGCAG 180

CCCCTCCTCC CTGCTGACCT CAACAAGGGC TGTGCTATTG TTTTTTATTT TATTATTTTA 24 0

TTTCTCTTTA TTATTATTAA TATTATTATT ATTTGCTTTT GCTGTGGTCA CTATCATTGG 300

CAAAGTTCCT TTTCCCTCGA G 321

(2) INFORMATION FOR SEQ ID NO: 1071:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 261 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1071:

GAATTCGGCC TTCATGGCCT AGGGAGGTAT TTGTCATTGT GAAAAG CTGG GAATCTCAAA 60

CATAGTCAAC TTAACTAAAA AG AAG CTAAT ACAGGTTGAG CATTCCTAAT CCAAAAATCC 120

AGAATCCAAA TTGCTCCAAA ATCTGAAACT TTCTGAATGC TGACCTGATA CTACAAGTAG 180

AAAATTCCAC ATACAAGTAC TTAACACAAA CTTTGTTTCA TGCACAAACT ACTAAAAATA 240

TTGTATAAAA TTAACCTCGA G 261

(2) INFORMATION FOR SEQ ID NO: 1072:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 304 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1072:

GAATTCGGCC TTCATGGCCT ACTTGGG CTC ATTTTATTTG GTGAATTTGA TCCTGGCTGT 60

GGTGGCCATG GCCTATGAGG AGCAGAATCA GGCCACCTTG G AAG AAG CAG AACAAAAAGA 120

GGCCGAATTT CAG CAGATGC TCGAACAGCT TAAAAAGCAA CAGGAAGAAG CTCAGGCAGT 180

TGCGGCAGCA TCAGCTGCTT CAAGAGATTT CAGTGGAATA GGTGGGTTAG GAGAG CTGTT 24 0

448

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GGAAAGTTCT TCAGAAGCAT CAAAGTTGAG TTCCAAAAGT GCTAAAGAAT GGAGGTCCCT 3 00

CGAG 3 04

(2) INFORMATION FOR SEQ ID NO: 1073:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1073:

GAATTCGGCC TTCATGGCCT AAAAAAGCTA ATGTCATAGG TCTTTATATG TGGGCAGGGT 60

TTATAAGTTG TCT£ A&GGGC CATCAGGTAG AGTTGGCCTT TTCTGTTGAG GT CCCCT AAA 120

TTTCAGTGGA GGTCTTCTCT TTGGGGCCAG TTTCTCTAGA AAACTGGGTC CTGATAGTAG 1B0

GGTAAGAAAA GACAGCTGAG GACCCCAAGA TTTGTATGAT GACTTTTACT TAATCCCTCT 24 0

ATCTTCATCC TCTCTCATGC CCATCCGGCC CCACCCCCCA AATCCTCCTC TGGCTGCTGA 3 00

CCCTCAGGTT CAGTTTTTCC TGTCAGTGGA GGTTGAGGGT GGGGCGTAGG CTGGCTGTGG 360

AGAGTAGGGG AG AGGAC CTG GGTTCCAGTA GCTCGAG 3 97

(2) INFORMATION FOR SEQ ID NO:1074:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 09 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1074:

GCGATTGAAT TCTAGACCTG CACCACTGCG ATCCCTACGC CTGAGGAAAT GACAAGATTG 60

AGAAGCATGA ACAGACAACT CCAGATAAAT GTTGACTGTA CACTGAAAGA AGTTGACCTC 120

CTTCAATCTA GAGGAAACTT TGATCCAAAA GCCATGAATA ATTTTTATGA CAACATAGAA 1B0

CCTGGCCCAG TTGTACCACC CAAG CCATCT AAAAAAGACT CCTCAGACCC CTGCACAATT 24 0

GAGAGAAAAG CCCGAAGAAT TAGCGTGACC TCCAAAGTAC AGGCAGACAT CCATGACACC 300

CATCTCGAG 3 09

(2) INFORMATION FOR SEQ ID NO: 1075:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 243 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1075:

GAATTCGGCC TTCATGGCCT AGAAAACTAA ACATTTGCCT TTTATAAAGA CTGACAAAAT 6 0

ATAAATCTTT ATTCTAACCC TATCCCCAAA ACTAG CCAGG CCACACCCCA GATGTTCTTA 12 0

TTGACTATTG GGAAGATAGA AAAGGCGTTG TGTTTTTTGT TTTTTTGTTG TTGTTGTCAT 18 0

TGTTGTTTTT TCAGAAGACC AGTGTCTCAG TTCTGTCTTA GTAGTACCAC ACCACGACTC 24 0

GAG 24 3

449

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(2) INFORMATION FOR SEQ ID NO: 1076:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5 98 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1076:

CTCGAGCTGG GGGCCACTTT GGCACCTAAC AAAAC CAGAG AAAACAAGTG CAACTAAGCA 6 0

AGCAACTATG CACATTCCAG ACATAAAGAT CATTAATAAA CGCCTTAATC TAAGGATCTG 120

TTGGTTCTAA CG C CAGAAAA AG AAGT TAAA TTTTAAAAAA T AT CTAAAAG AGATTTTAAG 180

TGGGCAAGCA ATAGAGAAGA TACCCAACAC TGAGAAACGG AAAGGAAAAA AGACCACCCT 24 0

AATAACTACT GCTCATCAAT ATACATCTAT AATTCTACCA GAACAGTATT AAGAAATGAG 300

AAACGCCAAT ATTACATAAA ATAAGGTAAA AATAACTAAG CAT AGGT TAG TGTCAGGGGA 360

CCTAGGGTTC AGACACCCAG AGTTTTATAT AAGGATAATT TGTCCTGAAT CAAGACCACA 420

CTGTCCTCTC CTTAAACCTA ACTGCTACAA GCAGACACCA CCTCTTCTGA CTGGGCTGAA 4 80

GTGTGGGAAA CAGTCCAAAA ATTAGGTATC ACAC CATAAA CCCTCCACAA GAGCAACCTT 540

TGCTCTCAAT TAAGTTGTTG ACAAAATAAT TCTCAACTTG CCTAGGCCTG CCGAATTC 598

(2) INFORMATION FOR SEQ ID NO: 1077:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1077:

GAATTCGGCC AAAGAGG CCT AGGTGGGTAT TTGAATGGTT TTGCTCCAAA ATTGAACTCA 60

CATTGTTGAT ATGACATGAA ACTAGCTGCA GCAAAAAATC CAGATACAGT AGATGAAAAG 120

ACTTGCTTTT CAGGAGGCAG CTGGTTGCCA TTTAAAAAGA AGATCATTTG CTTTTCATTC 180

AAGTCTAACA GAAATCCTAC TGTATCTCCT TCTTTCCAGC ATGGGTGTAT GTGAGGCTTA 240

CTTCTGGCAT TGTACCAAAT CAGCTGCCGG CAGCCATCAT ACGCACAGGA G T ATT CAT CA 3 00

TCCCCAATGC CG TAGCCTTC ATGATTGAGG AATTTGCTGT CTCGAG 34 6

(2) INFORMATION FOR SEQ ID NO: 1078:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 419 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1078:

GAATTCGGCC AAAGAG CCTA GCTCCTGTTA CCATTATTAT TATTCATACT CATATTCATT 60

ACTTCTAACT TCAAGTGGGC CATTAGCACT AACTGGCATA CCACACTTCT CTAGTCTATT 120

TATTCTCCTT GATGACTATT TGATACCCTT CCCTCTTTCC CCAAACTTCC AACACCTCCT 180

CTTCCCATCA TTCTCAGCTG ACGGCCTTGC TTTCTCCCAT GATTGGGACT AGAGAAGCAA 24 0

TTTGTAGGGA ATTTCCACAA GCTCCATCAC ATGTGGCCAC TC AT CTACAT CTGGATCCAT 3 00

450

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CTATTTGGCC TTCCCTATTG TTCTTATACA CTCTCCCTGT CTTACTTTAT CTAAGGTCAA 360
CATCTCCACT CCACTTATGC ACTAGATCCT GGCATTACAC CAGCAATCCT CACCTCGAG 419

(2) INFORMATION FOR SEQ ID NO: 10 79:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 261 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1079:

GAATTCGGCC TTCATGGCCT AGCTTATTCT TTTTTCTTTT TCTTTTTTTT TTTTTTTTTC 60

GAGACAGGGT CTTTCTTTGT CACCACAGGC TGCAGTGCAG TGTTGTGATC ATAGCTCACT 120

GCAGCCCTCA ACTCCAGGCC TCAAATGATC CTTCTGACTC AGCCTGCTGA ATGACTGACA 180

TTACACGTGC ATGCCGCTGT GCCCAGCTAA TTTTTAAATT TTTTGTAGAG ATGAGGTCTT 240

GCTTTGTTGC CCAGACTCGA G 261

(2) INFORMATION FOR SEQ ID NO: 1080:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 08 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1080:

GAATTCGGCC TTCATGGCCT ACATTAACAG ATTAATCCAT CTGTATAGGG CTTTTGCTGT 60

TGGATAGAAT TTAAATTGTC TACATAAATA TTTGTTTTAG G AC CCTTAGA TTTTATCTGA 120

ATACACAGAT TAGGCTTTAA AAACAGATAT ATATGTCATT TTTGGCTTAA GGAGTTTGGC 180

TAAGTTAGCT TTTCAACTGG TTCTCGAG 208

(2) INFORMATION FOR SEQ ID NO: 1081:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 425 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) . MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1081:

GAATTCGGCC TTCATGACTC CTGATTCAGG GGTCAGTTTA CTT CATAAAA AATCATTAGA 60

AAAGGAAGAA TTATG CCAAA GACTTAAAGA ACAGTTAGAT GCTCTTGAAA AAGAAACTGC 12 0

ATCTAAGCTG TCAGAAATGG ATTCTTTTAA CAATCAACTA AAGGAACTGA GAGAAACCTA 18 0

CAACACACAG CAGTTAGCCC TTGAACAGCT TTATAAGATC AAACGTGACA AGTTGAAGGA 240

AATTGAAAGG AAAAGATTAG AACTAATGCA GAAAAAGAAA CTAGAAGATG AGGCTGCAAG 300

GAAAGCAAAG CAAGGAAAAG AAAACTTATG GAAAGAAAAT CTTAGAANGG AGGAAGAAGA 3 60

AAAACAAAAG CGACTCCAGG AAGCCAAGAC ACCAGNAAAA ATTCCAAGAA GAGGAACGTC 420

TCGAG 425

451

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(2) INFORMATION FOR SEQ ID NO: 10 82;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 299 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1082:

GAATTCGGCC TTCATGGCCT AAGACTTCTT GCAGGAAAAA TGAGTGCATT GAGGATAGTA 60

ACCTGACTTT CTGACCTGTG ATTAAATTAT GATAGTAGTC AGTCATTTTA CTCTCCCAGG 120

GTTTGAGGAA GTGGCCGGTG AGGACTTGGA GCCTAGTGAG GAGTTAGTAG AGCTGCCCAG 180

GGTGGAGGAG GCCACAGAGG ACAGCCCTGG TGAAGAGAAC AGTGAGGCCT TGGATGTGTT 240

GATATCCAGC AAGGACCTGG CACTGTCTAG TGAGGACGAG GCCTGCACAG GATCTCGAG 2 99

(2) INFORMATION FOR SEQ ID NO: 108 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1083:

GAATTCGGCC TTCATGGCCT AAGTCACTTG TGTAACGTAG TTATACTTTG C TG CATTNTA 60

ATTAACCTTC AACAGCTATT AAAGTGGAAT GTAAG TTAAA TTTTGAAGGA AAGGAAATAA 120

ATGTTTTCCA TATTTCGTCT TGATTTACTT TCTGTATGAG AACAGCTGTG TTTTTGATAG 180

GTTTATGGTT TGCATGAGTT CATATTTAAA GTGATCCAGG CCAATGCATG GCTATTGCTG 24 0

TAAATCTTGA TGTTTATTTC TGCCTTGTAA AGTTCTATCA CGGCCTACCT G GAATTT AAA 3 00

ATTCAGTAGA CAAATTAATT GGTCCTCTGC ACAACTTTTT TAATAAGTAG ATTATTTTAC 3 60

AAAGAAATTT GAACAAATTT AATTGAATCT TTTGTTTAGC TTGCCTCTAA GAACTTTTCT 4 20

TAATAAAGCT CCCAAACACT CGAG 4 44

(2) INFORMATION FOR SEQ ID NO: 10 84:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1084:

GAGTGAGACT CCCTCTCAAA GGAAAAAAAA AAGTTTTCTA GGATCAAAAT AGGAAAACAG 60

TTGTTTCAGA ACTCATGATA TGAGTCATGA CTACAACCCA C CATATTCAG TAAAACCTCA 120

CCTTGTCCTG TTGTCTGACA TTAAGTGTTC TACGAGATCC ATACCTGTGA AATCAGCTCC 180

TCTGGAATGA CAGATGCTGG AATAACTGGC TGGGGCTGAC TG CCCAAAAG CCCAGACCCT 240

CGATCCCGTC CTGTCCGAAT AACTCGAG 268

(2) INFORMATION FOR SEQ ID NO: 10 85:

452

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 251 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1085:

GAATTCGGCC TTCATGGCCT ACTTTAAGTG AACAACANCA ACAAAAAAGT TAAGGGTAAG 6 0

ATGAGGCAGC TTTTCAGTGG AAAATACTTG TCTTGGGGAC AGTATGTCAT GTCCCTATAC 12 0

CTGGTGCCAT TGATAAGGTT ATTCATTCAA CAATATTTAC TGATCACTGG CAT ATG CCAA 180

GCACTCTGCC AAGTACTAGG GATATAAACA TTAGAAAGAC AAGTTCCTCC CTTTTCAGTC 240

ACGATCTCGA G 251

(2) INFORMATION FOR SEQ ID NO: 1086:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 258 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1086:

GAATTCGGCC TTCATGGCCT AGAGCTTCAC GGAGGCAAGA GGGTAATGGA GTGCCTAAAA 60

AAAGCTCTAA AAATAGCAAA TCAGTGCATG GACCCCTCTC TACAAGTGCA G CTTTTT ATA 120

GAAATTCTGA ACAGATATAT CTATTTTTAT GAAAAGGAAA ATGATGCGGT AACAATTCAG 180

GTTTTAAACC AGCTTATCCA AAAGATT CGA GAAGACCTCC CGAATCTTGA ATCCAGTGAA 240

GAAACAGAGC AACTCGAG 258

(2) INFORMATION FOR SEQ ID NO: 1087:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10 87;

GAATTCGGCC TTCATGGCCT AATAAAAAGA ATTATCAAAG AATTGCAGGG GAAACCCCAT 60

AGAGAAGACT CATTCTTAGA TGAGTATACA ATCCATGGGG GTCTTTAGGA TATTTAACTG 120

ATTTGGGAGA GG TCGGATAA AGAAAAAGGA GCATTAACCT TGACTATGCC TTTAGCTCCA 180

GCCGCCTCTT TAAGAGGAAA TTGTTGGGCA GGTGGGGGAA GGCTAGTCAT GGAACGAAAC 24 0

TGTAAGCCAG ATCGGGTGTG AGGAGGGGAG GTGATAAAAG GATTATAGGG TGGGAGAGCA 3 00

CAGGCTGAGG AAGAATTGGG ACCTGGCTCA GCCTGGCAAG GCACAGCCTG GGGAGGAGGG 360

GAGAGGTCCT GTAGAAAAGG AGGATCTCGA G 3 91

(2) INFORMATION FOR SEQ ID NO: 1088:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 368 base pairs

(B) TYPE: nucleic acid

453

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(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1088:

GAATTCGGCC TTCATGGCCT AGCCTTCNAA GTTTGAATGG CCCTTAGGTT TTAAGTTATC 6 0

TATGCAAAGA TGAANAAGGC CTTCACATTC TCAAAGGTGA CAACTCATAC CCAGCCATTT 12 0

GCTTATTTTT GCCTGCAGAC CTCCAATGGA AGTCCGGGCA CATGGCGGAG AGCCTCACCA 180

ACATGCCACG GCACTCCCTC TAC AT CAT CA TTGGAGCCCT CTGCGTGGCC TTCATCCTTA 24 0

TGCTGATCAT CCTGATCGTG GGGATTTGCC GCATCAGCCG CATTGAATAC CAGGGTTCTT 3 00

CCAGGCCAGC CTATGAGGAG TTCTACAACT GCCGCAGCAT CGACAGCGAG TTCAGCAATG 3 60

CACTCGAG 3 68

(2) INFORMATION FOR SEQ ID NO: 108 9:

(i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 4 09 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1089:

GAATTCGGCC TTATGGCCTA GTTCATTTAA CTAATACTTG TATTAAATCA CTTCTAAATG 60

CTTATTATAC CCTGTATTAT AGTATTATAT TCTGAGTCTT AAAGGTGCTT AATGTGAAGA 120

TTCTCTCTCT ACATATTCAA CTCTTACTAA CTTTTGGCTT TAGGTAGAAA TCAGTTAGTG 18 0

TATTATATGA TAAAATAGGA AACTATTTCC CTAGGGGTAT AGGTATTCAG TAGGGAGCTT 240

TGGAGTCTCA ATGAGCTTCT TAAAGAAGCA TTTTTAATGG TAGGTTTTAG GGAGAGTTTT 300

TGTAGTAAGA TAAAGTAGAT GAGAAAGTGT TGCCTCTAAA CAATCAACAA GCTGGGAATG 360

GGGTGCAGAA TGAGGAGAAC CCTAAGCAAT AGG CAATAAG AAGCTCGAG 409

(2) INFORMATION FOR SEQ ID NO: 1090:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 359 base pairs

(B ) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 1090:

GAATTCGGCC TTGGCCTAGT GAG AG AG CGT CAAAAAAACT TCCATCTCAG CCAACCACTG 60

ATACTAGTAC TGACAAAGAA AGAACTTCAG AGGACATGGC TGATAAAGAA AAATCTACAG 120

CTGACTCTGG AGGTGAAGGA CTGGAAACAG CCCCAAAGTC TGAAGAGTTC AGCGACCTCC 180

CCTGTCCAGT CGAAGAAATT AAAAATTACA CAAAAGAGCA TAATAATTTA ATTCTGCTAA 24 0

ATAAGGATGT TCAACAGGAA AG CAGTGAGC AAAAAAATAA ATCAACAGAC AAAGGTGAAA 3 00

AG AAG CCAGA CAGCAATGAG AAAGGAGAAA GAAAGAAAGA AAAGAAGGAA AAGCTCGAG 359

(2) INFORMATION FOR SEQ ID NO: 1091:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 0 base pairs

(B) TYPE: nucleic acid

454

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(C) STRANDEDNESS ; double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1091:

GAATTCGGCC TTCATGGCCT ACATG TT CAT TCTAAGAAAC TTAACTCCAT TTTTAAGCTT 60

TAAGATTCCC CCGATCCCAA ATAACCTAAC ACACCAAAAG CCTTGCCATT T CAC ACATG C 120

TGTTCCTTTG CTTAGAACCT TTTCAATGTC TAGCTCACTC TGTTTGGGAC TTCTTTTTTC 180

TTTTCTTTTT TTTGAGACAG GGTCTGGCTC TGTCATCCAG GCTGGAGTGC AATGGGGCAA 240

TTTCGGCTCA CTGCAACCTC CGCCCTTCCA GGCTCAAGCG 280

(2) INFORMATION FOR SEQ ID NO: 1092:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1092:

GGAAAATTGA GAAAACCATG AAAGAAAAAG AAGAACTGTT AAAGTTAATT GCCGTTCTGG 60

AAAAAGAAAC AGCACAACTT CGAGAACAAG TTGGGAGAAT GGAAAGAGAA CTTAAC CATG 120

AGAAAGAAAG ATGTGACCAA CTGCAAGCAG AACAAAAGGG TCTTACTGAA GTAACACAAA 180

GCTTAAAAAT GGAAAATGAA GAGTTTAAGA AGAGGTTCAG TGATG CTACA TCCAAAGCCC 240

ATCAG CTTGA GGAAGATATT GTGTCAGTAA CACATAAAGC AATTGAAAAA GAAACCGAAT 3 00

TAGACAGTTT AAAGGACAAA CTCAAGAAGG CACAACATGA AAGAGAACAA CTTGAATGTC 360 ,

AGTTGAAGAC AGAGAAGGAT GAAAAGGAAC TTTATAAGGT ACATTTGAAG AATACAGAAA 420

TAGAAAATAC CAAGCTTCTC GAG 44 3

(2) INFORMATION FOR SEQ ID NO:1093:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 256 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1093:

GAATTCGGCC TTCATGGCCT ACCTCCATTG TATATTAACA TTTATCATAA TTATTATTTG 6 0

CTCATTCAAA AAATATTGCT CTGATATGGT ATTGAATATT CCTCACATAG GAAAATATGA 120

ACAGTTTATT TGCCACCCAG ATGGTTTGGA AGCCTATACC CTC CAAGACA TTGAGAAAAG 180

AAAAATCTTT CTCTCAGGAG AGAGAATGAG TGCCAAGCAA TGGGAGAAGC CCCTTAAAAA 240

ACCATCAGAT CTCGAG 2 56

(2) INFORMATION FOR SEQ ID NO: 1094:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 454 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

455

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(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1094:

GAATTCGGCC TTCATGGCCT AAGCTGTTAG TGATTCTGAC ACCCTTGGAC CTCCAGGAGT 6 0

AGCTCCTCCT GCCACGAGAG GACTCTGGCT TTTCTAATAA GGAAGGTTCT GGCCAATCAG 12 0

TCCAAGAAAG GCCCGGATTC TCTTCCAAGG TGTTGTCTCT GCAGAAATGT TCCTCAGGGT 180

GGAAGGTGCT GCTGCAGCAA GGGATGTCCC CTGAGTTTTC AGGTATGTAG TCTGTGGCTG 24 0

CAGCAGGTGA ACACTCCTCA CACTCCCATT TCTTACTGTT AGATCTAAGA GAGGAGCAGT 300

CCCTGTGGGT TCCGTGGGAT CCGCATGTAG CACACAGAAT GAGGCACCAC CTCCCTTCAT 36 0

CCTCAAAGCT GTCTCTGCCT TGTTCATACA GACAGATGGG GGCATCACAG TGCTGATAGC 4 20

GCTGATATAA GTCTGAGAAA GCCCCTGGCT CGAG 454

(2) INFORMATION FOR SEQ ID NO: 1095;

(i> SEQUENCE CHARACTERISTICS :

(A) LENGTH: 44 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1095:

GAATTCGGCC TTCATGGCCT AGTGATCTCA TCTCTCCGTC CATGGGCGAA AAAACAGCCA 60

TCACCAGGCC ATTCACGCTT TGTGCTTTTG TTAGCAGAGC CCAGGCAGCC CTGCAGCCCA 12 0

CATCTAGGGT ACAAACGGAA CGGCGGCGTT TTCCTTGTAT CATTTAGAGG AAATTTTTGA 18 0

GCTGAACAGT ATTTTTTTTC TCCCTCTCTC TCTCTCTGAA ATATTGCTGA GATTTAAAGG 24 0

AGGACGAAGA CAACAGATTC ATAGCTGGGT CTTGCTGTTT TCCTGACGCT GACCACAGCG 3 00

GATCTAGTTT CTCTGCAGAA GACAGCAAGA TGCCCCAGGG AATGTTTGTG AAAAAGGATG 360

ACTGGATGGG AAGCAAGCTG AAGAAAAAGA AGGAAAGAAA GAGAGAAATC AGTAAATCAC 420

CACACAAGAG GTGGAGAAGA GGACTCGAG 44 9

(2) INFORMATION FOR SEQ ID NO: 1096:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 166 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1096:

GACTGGCCGC AAGGGACGGG TTGTGAGCAA TGATGATGGA AGCATATCTT ATGAGTCAAG 60
ATCTGAACTT GATGTG CCTG TGGAAATACT AAACATCACA GAAAAACAAC GATTTATGGA 120
TGGAGATAAG AATATTGCTA T CATCTCAGA AGCTGCCATG CTCGAG 166

(2) INFORMATION FOR SEQ ID NO:1097 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 501 base pairs

(B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

456

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1097:

GAATTCGGCC TTCATGGCCT ACATTATTTA CACCTGTCCC AGACTTTGAT TCAGGAACTA 6 0

ATGCTGCAAA GCAAGGACTA TGATGGAAAA TGCTCACTGC AAGAATGGTA GCTGCAGCAA 120

GATCAAGATC CCAGAAAGCA GTGGCCAAGG CACTCACTGT AGACTTTAGT GCCTGCAGCA 180

TCTGGTGCAA GCTACACTGT CTACGCCCAG G AAC AC AG C A GCAGCATCCG GCCTGGGCCA 24 0

ATTCTGTGTA AGATTTGATG CGCTGTCCCT GGCTGCAGTG CCTGCAGACA TCTCTCTCTA 30 0

GCCCTTCTAA CAATTTCACA GCAACTCAAC ATCTTTAAAA ATTTATTAGC CAACCAAAAT 3 60

CAGCTTCTGT GGCATGCAAG TAAAAAC CC A GGCTGATATG TCTGAATACA GAAGATTTAT 4 20

ATTAGTTCCT TAGAGTCAAT AATCCATACA GACTCTATTC TAGCTTCTTT GTGAAGTGGG 4 80

TAAGAATT CC TCTGCCTCGA G 501

(2) INFORMATION FOR SEQ ID NO; 1 09 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 82 base pairs

;3) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1098:

GAATTCGGCC TTCATGGCCT ACTTCAAAAA CATATATTAA TATTTTTGTA CCACGTAAGT 60

TCATCAGAAG CCTGACTTTA ATCTCTGATT TATTATATTT GAACACTGTG AAGAAGCAGT 120

TTAACACTGA ACGAAAGTGT CGTAATG CAG CTTTCAAAGT GGCCATTAAA GACAGATCTC 180

TGCTTTTCTA TTAGTACATT TTCTAAGATG ACTATCATTG CCATTGTAGT CAGCTTTGTG 24 0

TACCTTTATA GAG ATT CCAG TATAAACCCA GAAACGCTCG AG 2 82

(2) INFORMATION FOR SEQ ID NO: 1099:

ti) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 266 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1099:

GAATTCGGCC TTCATGGCCT AGGAAACTTT TCAAAGAAGT AGTCCACGAG AACTACCTTG 60

AAAGAGCAAA ACCAGCCAGG TGCAGTGGCT CACGCCCATA ATCCCAGCAC TCTGGGAGGC 120

CCAGGTGGGT GGATCTCGTG AGGTCAGGAG TTCAAGACCA GCTTGGCCAA CATGGTGAAA 18 0

CCCCATCTCT GCTGAAAATA CAAAAGTTAG CTGAAAATAC AAAAGTGGCA CATGCCTGTA 24 0

ATGCCAGCTA CCGGGAAAGG CTCGAG 266

(2) INFORMATION FOR SEQ ID NO:1100:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 310 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1100:

457

WO 98/45437 PCT/US98/06956

CTCGAGCGTA TCCCAGAACT TAAAGTATAA TAATAATAAT AATAATAATA ATAATAATAA 6 0

TAATAAAACC TTCCAACAAG CTTCCTTTCC ACCACAGGAA ATCCTGTTGG GAGTTCCCCC 12 0

TGAACCAAAA AAAAAAAAAG ATAGAGTATA AAACATACAC TTTTCAGGAA TGCTTATTGG 18 0

GTAATGTAAG ATAACACCTC AAAATGAAAC TCAGAATTTT ATTTTATTTT ATTTTTTGAG 24 0

ATGGAGTCTC ACCTAGGCTG GAGTTCAGTG TGGTAATCTT GGCTCACTGT AGGCCATGAA 3 00

GGCCGAATTC 310

(2) INFORMATION FOR SEQ ID NO:ll0l:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 367 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1101:

GCGATTGAAT TCTAGACCTG CCTCGAGTGT ACCTCATTCT GCCATCTCTG ATAT TATGTC 6 0

ATCTGATCAA GAAACTTACT CTTGTAAACC TCATGGACGG ACTCCACTTA CCTCAGCTGA 120

TGAGCATGTA CATTCCAAAC TGGAAGGAAG TAAAGTAACG AAAT CTAAG A CTTCTCCGGT 180

GGTATCTGGT TCATCTAGTA AATCAACCAC CCTTCCAAGG CCACGACCTA CCAGGACTTC 24 0

CCTCTTGCGC AGAG CACGAC TTGGTGAAGC TTCAGACAGT GAACTTGCTG ATGCTGACAA 300

AGCATCTGTT GCTTCTGAAG TAT CCACAAC AAGTTCTACA TCAAAACCTC CCACAGGAAG 360

GCTCGAG 3 67

(2) INFORMATION FOR SEQ ID NO: 1102:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1102:

GAATTCGGCC TTCATGGCCT AAGAAAGCAA GAAAGCACGA AAGCAATCAA GCAAGAAAGC 6 0

AAGCAGGAAA GAAACAAAAG AAAGAAAGAA NGCGAGAAAA CAAGAAAGCA CGAAAGCAAG 12 0

CAAGCAAGAA AGCAAGCAAG AAAGAAACAA AAGAAAGAAA GAAAGAAAGN AAACAGGAAA 180

GCAAGAAAGC ACGAAAGCAA GCNAGCAAGC AAGAAAGCAA GCAAGAAAGA AACAAAAGAA 24 0

AGAAAGAAAG AAAGAAAGAA AAAGAAAACA GGAAAGCAAG AAAG CACGAA AGCAAGCAAG 300

CAAGCAAGAA AGCAAGCATG AAAGAAACGA AAGAAAGAAA GAAAGCAAGA AAACGGGAAA 360

GACTCGAG 368

(2) INFORMATION FOR SEQ ID NO; 1103:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 1103:

458

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PCT/US98/06956

GAATTCGGCC TTCTGGCCTA GAAACCCGTG ACACACACAC ACACACCTGC ATAGATTTTT 6 0

CCCAAGCACA CGATATGCAC GTGGATACAC AGACTTACAA GCACAGGGCC ACGTGCAGAC 12 0

AGACACAGAC CCTGTCTGCA CCACAAACAT ACCACACACA GCCACACACA CAGAAGCCAA 18 0

ACATCCTCGC ATAGGTGGAT ACAAGCACAG ACT CACAT AC ACATATGCGA TACACATATG 24 0

GATACATACA CAGAGTACCC CCACAAACAC ACAGACACAC ACGGG CAG AG ACAGACAGAG 30 0

ACAGGCACAG ACCCCCCCCC ACCTCGAG 32 8

(2) INFORMATION FOR SEQ ID NO:1104:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNES5 : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1L04:

GAAAAAAACT GAGTTAATGG CCATGACTAG ATGGGAGGTC AGATTCGCCG TTATATCCTC 6 0

TCTGTTTTGC AGTTTAGACA CAACTGACCA GCATTGTTAA AATGGAGATC ATACGG CTGG 12 0

TAGAACAGAC TCTTTGTGGC C CAAAATTAG CAAATTATAA ATAGAATCTA AAGCCATCCC 18 0

AGGCAAGGGT TAAGTTATGC ACCCCTACAC TTAAAGAATA AACTATGTTG GCCGGGCCAA 24 0

CTCGAG 24 6

{2} INFORMATION FOR SEQ ID NO: 1105:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 298 base pairs

(B> TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1105:

GAATTCGGCC TTCATGGCCT ACGATCAGAA AGAAAACACA GATCTCGAAG TCGGGATCGA 6 0

AGAAGATCAA AAAG CCGGGA TCGAAAGTCA TATAAGCACA GGAG CAAAAG TCGGGACAGA 120

GAACAAGATA GAAAATCCAA GGAGAAAGAA AAGAGGGGAT CTGATGATAA AAAAAGTAGA 180

GAAAGAAGGC GGAGCAGAAG TAGAGATCGA CGAAGAAGCA GAAGCCATGA TCGATCAGAA 24 0

AGAAAACACA GATCTCGAAG TCGGGATCGA AGAAGATCAA AAAGCCGGGA AG CTCGAG 298

(2) INFORMATION FOR SEQ ID NO:1106:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 211 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1106:

GAATTCGGCC AAAGAGGCCT AGGGATGGAT GGTTCAGCTG CTAGAATTTC GATG CAGGAC €0

TTCTTCAAAA TTGAGTGGAT GATGCCTTGC AGAGCCTGAA AGCCGTCATT CACGGGAAAC 120

ACATGATCCT TACTGTCCGC AATCCGGGCC AGCTGTGTCT CAT TGAAAT C TTTCACACCA 180

ACACAGTAAA CAATTGCACC AAGATCT CGA G 211

459

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(2) INFORMATION FOR SEQ ID NO: 110 7;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 269 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1107:

GAATTCGGCC AAAGAGG CCT ACCTGCTTGA ATTGGGGCCC CTTGTGAAGC TGCTGCCGCA 6 0

TCTCTTCCAT TCGCTGCTTC CGGTACTGCT GCAGAAACTC TTCATCATCT TGGTCCTCAT 120

TCATTATGGC AAACTCCTTC AGAGTCATCT TCCCACTGAT CTTCTCCTGG AGGTCTTTCT 180

GTTTCTGTTG CTCCTCCTCT TCATCCAGAT GGGACCTGCA AGTCATTGAC AGCTTCTTGA 240

TCAGCCTTTC CATCTCCCGG CAACTCGAG 26 9

(2) INFORMATION FOR SEQ ID NO: 110 8:

(2) INFORMATION FOR SEQ ID NO: 1109:

(2) INFORMATION FOR SEQ ID NO: 1110:

60
120
133

60
120
123

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1108:

GAATTCGGCC AAAGAGG C CT ATGAAAATTG ACTG CAATTA GTAAAGTTGG TATAACGTAC
GTTCCCAGTT GTGCTATTTA GAATTATGAT AGTATTATGC TCCTACTTTT CTTTGATATT
GAGTAGTCTC GAG

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 3 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1109:

GAATTCGGCC AAAGAGG CCT AGCTTTTTCT AATCATAAAT TATATGACCT TTACAGAAAA
TTTAGAAAAT ACAGAAAAAC TGAAAAGTTA CACATGGTAC AACTCACAAC CACAATCCTC
GAG

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 0 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

460

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PCT/US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1110:

GAATTCGGCC AAAGAGGCCT AGTGTTCCAG ATCCTACGGC TTATGAGGAT TTTCCGAATT 60

CTAAAGCTTG CCCGGCACTC GGTAGGACTT CGGTCTCTAG GTGCCACACT GAGACACAGC 12 0

TACCATGAAG TTGGGCTTCT GCTTCTCTTC CTCTCTGTGG GCATTTCCAT TTTCTCTGTG 180

CTTATCTACT CCGTGGAGAA AGATGACCAC ACATCCAGCC TCACCAG CAT CCCCCTCGAG 240

(2) INFORMATION FOR SEQ ID NOtllll:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1111:

GAATTCGGCC AAAGAGGCCT AGG TGGGGAG GGGAGGGGAC AGGAGAAATG AAATACCTTC 60

ACCGAGAACT CAGCAGCTGC CACCGCAGCT GCCTCCTCAG GATCCGGTCG TCGGGGATAG 120

GGAAGGGAGG GGAAAGGGGA ACGG AAAACA AAAAAAAGGG GGAGGGAAGG GGGAGGAAGG 180

AGTCGGGGAC GGCCTCAAAC TCAGCTCAGA GGAGTCGCTG CTGCAGCCGC CACTCGGTAC 24 0

CCGCTGCTAG GCCTCTTTGC CGAG 264

(2) INFORMATION FOR SEQ ID NO: 1112:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 519 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

. (ii) MOLECULE TYPE : cDNA
(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1112:

GAATTCGGCC AAAGAGGCCT AAATATTAGA AAATGTATAT TATAGAACAT GATATATATT 60

TACATTCATC TCTGTATTCT CTCAGCTGTT GTTAGAAGGA CAGAATGTTA AACTTTATCT 120

TAATTAGTAT ACTAGAAAGG GCAGTATAAT ACTGTTTTAA AGTGAAGGCA TGACTGAAAC 180

TAAAATATTT CATAAGG CTT AGCTAGAGGC AGAGTAACGT GTTTTTGTTC ATTGGGCTTC 24 0

CTTGTACTTA GTTTTTTCAT TTAATAATTC AAACCAACAC TTTTAAAAAA ATAATTCAGA 3 00

TGAGACTGAG CCATATCTGC AGTAAGAGAA ATATTTCTTA ATGTTTTGGT TACTTATGAT 3 60

AGAGTACTTT TCTTGATACT GTTAACTTTG TGCTTTTTAA AAAAAGTGAT TCTCTAACAG 420

ACCTCTTAAA TTGTGACATG AAGGTATGTA ATTAGATTTC AGAAATTGGT TTATTAGTGA 4 80

GGAATTTTTA T CAATAAATG TCATGGGGCG GCGCTCGAG 519

(2) INFORMATION FOR SEQ ID NO: 1113:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 562 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1113:

461

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PCT/US98/06956

GGCCCACCTA GTTGGTATCC
CTCCAAAATA CTTGTAATTC
CAAGGCCCTT CACAGAATCG
TGTTCACTAG ACAGGAGTTT
GCTCTGATGG CTTCCAGTCT
ACCTGCCCCA CCTCCACCTT
CCTTAGCTCA ACATGTGTCC
TTCCTCATGT GCAGTTATGT
TGTCAAAAGC TAAAGTCATG
GTAGGCCTCT TTGGCCGAAT

CAAATTCACA CATTCAAAAG CAAAGCCATT TCTCACCTTC
CTAATATCCT GACTCCAATC CATTCTTTAT TTTCTATTCC
AAACTTTTGT TATGAGCTCT TACATGGTGT AT CATC AAT A
TTTTTAAAAA AAATCCTCAT CATTCCTCTT CAATTCAAGA
ATACAAGATA TATTAAGGCT CAACTTACAG TTCCAGTCTC
CCCAAACCCT CTGTATTCTA GCCAG AG CAT ACCTGCATTC
TTGCTCACAC TGTCCCTTTG GTTGACCTAG CTTCAATTCC
GTCTACTAAG CAGCAATGTG AAATGTCTTT ATTGTAGGTC
GCCCGGTGCA GTGGCTTGGG CCTGTAATCC CAGCACTTTG
TC

60
120
180
240
300
360
420
480
540
562

(2) INFORMATION FOR SEQ ID NO: 1114:

(i) SEQUENCE CHARACTERISTICS ;

(A) LENGTH: 435 base pairs

(BJ TYPE: nucleic acid

(C) STRANDEDNESS : double

«D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1114:

GAATTCGGCC AAAGAGGCCT ATTATTGCTA TCGCCCTCCT TTCCCTTATT GCCTCCCAGG 60

CAAGCAGCTG GTCAGTCTTT GCTCAGTGTC CAGCTTCCAA AG C CTAGACA ACCTTTCTGT 120

AGCCTAAAAC GAATGGTCTT TGCTCCAGAT AACTCTCTTT CCTTGAGCTG TTGTGAGCTT 180

TGAAGTAGGT GGCTTGAGCT AGAGATAAAA CAGAATCTTC TGGGTAGTCC CCTGTTGATT 24 0

ATCTTCAGCC CAGGCTTTTG CTAGATGGAA TGGAAAAGCA ACTTCATTTG ACACAAAGCT 3 00

TCTAAAGCAG GTAAATTGTC GGGGGAGAGA GTTAGCATGT ATGAATGTAA GGATGAGGGA 360

AG CGAAG CAA GAGGAACCTC TCGCCATGAT CAGACATACA GCTGCCTACC TAATGAGGAC 42 0

TTCAAGCCCC CTCAG 43 5

(2) INFORMATION FOR SEQ ID NOilllS:

(i) SEQUENCE CHARACTERISTICS:

<A) LENGTH: 477 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
CD) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1115:

GAATTCGGCC AAAGAGGCCT AGTGC CTAG A TTGATCGGTA TAAGG CTCAC TCTCCCGCCC 6 0

CCCAAAGTGG TTGATCGTTG GAACGAGAAA AGGGCCATGT TCGGAGTGTA TGACAACATC 120

GGGATCCTGG ■ GAAACTTTGA AAAGCACCCC AAAGAACTGA TCAGGGGGCC CATATGGCTT 180

CGAGGTTGGA AAGGGAATGA ATTGCAACGT TGTATCCGAA AGAGGAAAAT GGTTGGAAGT 24 0

AGAATGTTCG CTGATGACCT GCACAACCTT AATAAACGCA TCCGCTATCT CTACAAACAC 3 00

TTTAACCGAC ATGGGAAGTT TCGATAGAAG AG AAAG CTG A GAACTTCGGA AAAGGCTCAT 360

CTGTCACCCT GGAGAAGGGA AACTGTACTT TTCCCTGTGA GGAAACGGCT TTGTATTTTC 420

TCTGTAATAA AATGGGGCTT CTTTGGAATT TGATAAGCCT AGGCCTCTTT GGCCGAA 477

(2) INFORMATION FOR SEQ ID NO: 1116:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 620 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

462

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PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

txi) SEQUENCE DESCRIPTION: SEQ ID NO: 1116:

GAATTCGGCC AAAGAGGCCT
TCATCTTGGA GAAGCAAGCA
CAAGTGAATT TTCCCAATTT
GCAAGCAACA AACTGAATCC
CCAATGATCA TGACCAGTCC
CGACAAAATC ACAACGACAT
GCAGAGACCA TGATAAATCA
GCAAAGCTCA TCGTGGGACA
AGGGAATATC CAGTCAATAT
AAGAACAAAC TTCCGTCTCT
GTTATGTTCT CCAAACTGAA

AAGATGAAGC CCAACATCAT CTTTGTACTT TCCCTGCTCC
GCTGTGATGG GACAAAAAGG TGGATCAAAA GGCCGATTAC
CCACACGGAC AAAAGGGCCA GCACTATTCT GGACAAAAAG
AAAGGCAGTT TTTCTATTCA ATACACATAT CATGTAGATG
CGAAAAAGTC AG CAATATGA TTTGAATGCC CTACATAAGA
CTAGGTGGAA GTCAACAACT GCTCCATAAT AAACAAGAAG
AAAGGTCATT TTCACAGGGT AGTTATACAC CATAAAGGAG
CAAAATCCTT CTCAAGATCA GGGGAATAGC CCATCTGGAA
TCAAACACAG AAGAAAGGCT GTGGGTTCAT GGACTAAGTA
GGTGCACAAA AAGGTAGAAA ACAAGGCGGA TCCCAAAGCA

60
120
180
240
300
360
420
480
540
600
620

(2) INFORMATION FOR SEQ ID NO: 1117:

<i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 158 base pairs
<B) TYPE: nucleic, acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1117:

GAATTCGGCC AAAGAGGCCT AGACCTGCCA CATTTGTTAA CATTTTTCCA TTTCTAAACC 60
ATCCTTAAAG AAAATCATAT ATGGGGTCAC ACCATCCTCA CGGTAGTCCA ATAGAGCAAC 120
CATGCCATCT GGATTCATGT TTTCACCAAA CCCTCGAG 15 B

(2) INFORMATION FOR SEQ ID NO: 1118:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 410 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:lllB:

GCACTGCTTC TGTTAAAGTC ACTGACCTTA ACAGT TTAGA ACTAGATAAA GGAAATTTTG 60

TGGTTGACCA .AATGTGTGAA ATAGGTAAGC CAGAACCATT GAATGAGGAG GAAGCAAGGG 120

GTGTGGTTGA GAATTATAAT GATGAAGAAG TGTCAATTAG AGTTGG TGGA AATACACAGC 180

CAAGTAAAGT TTTGAACAAA AAAAATGTAG AAG CTATTGG ACTTCTTGGA GGACAAAAGA 24 0

GCAAAGCAGA TTATGAGCTA TACAACAAAG CCTCTAATCC TGATAAGGTT GCTAGTACAG 300

CGTTTGCTGA AAATAGAAAT TCTGAGACTA GTGATACTAC TGGGACCCAT GAATCTGATA 360

GAAACAAGGA ATCCAGTGAC CAAACAGGCA TTAATATTAG TGGACTCGAG 410

(2) INFORMATION FOR SEQ ID NO: 1119:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 452 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

463

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(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1119:

GAATTCGGCC TTCATGGCCT AGTTG CCCTA ATTTGCAGCC GAACTTGGAA GCCACTGTAT 6 0

CCAATGGACC TTTTCTGCAG CTTTCTTCCC AGTCTCTTAG CCATAATGTT TTTATGTCCA 120

CCAGTCCTGC ACTTCATGGG TTATCATGTA CAGCAGCAAC TCCGAAGATA GCAAAATTGA 18 0

ATAGAAAACG ATCCAGATCA GAGAGTGACA GTGAGAAAGT TCAGCCACTT CCAATTTCTA 24 0

CCATTATCCG AGGCCCAACA CTGGGGGCAT CTGCTCCTGT G AC AG TG AAA CGGGAGAGCA 3 00

AAATTTCTCT TCAACCTATA GCAACTGTTC CCAATGGAGG CACAACACCT AAAATCAGCA 3 60

AAACTGTACT TTTAT CTACT AAAAGCATGA AAAAGAGTCA TGAACATGGA T CCAAGAAAT 42 0

CTCACTCTAA AACCAAGCCA GGTTATCTCG AG 4 52

(2) INFORMATION FOR SEQ ID NO: 1120:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 592 base pairs

( B ) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO -.1120:

GAATTCGGCC TTCATGGCCT ACATGAAT CT ACTTCTGATC CTTACCTTTG TTGCAGCTGC 6 0

TGTTGCTGCC CCCTTTGATG ATGATGACAA GATCGTTGGG GGCTACATCT GTGAGGAGAA 12 0

TTCTGTCCCC TACCAGGTGT CCTTGAATTC TGGCTACCAC TTCTGCGGTG GCTCCCTCAT 18 0

CAGCGAACAG TGGGTGGTGT CAGCAGGTCA CTGCTACAAG TCCCGCATCC AGGTGAGACT 24 0

GGGAGAGCAC AACATCGAAG TCCTGGAGGG GAATGAACAG TTCATCAATG CAGCCAAGAT 3 00

CATCCGCCAC CCCAAATACA ACAGCCGGAC TCTGGACAAT GACATCCTGC TGATCAAGCT 3 60

CTCCTCACCT GCCGTCATCA ATTCCCGCGT GTCCGCCATC TCTCTGCCCA CTGCCCCTCC 42 0

AGCTGCTGGC ACCGAGTCCC TCATCTCCGG CTGGGGCAAC ACTCTGAGTT CTGGTGCCGA 4 80

CTACCCAGAC GAGCTGCAGT GCCTGGATGC TCCTGTGCTG AGCCAGGCTG AGTGTGAAGC 54 0

CTCCTACCCT GGAAAGATTA CCAACAACAT GTTCTGTGTG GGCTTCCTCG AG 592

(2) INFORMATION FOR SEQ ID NO: 1121:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi> SEQUENCE DESCRIPTION: SEQ ID NO: 1121:

GAATTCGGCT TCATGGCCTA AATAATTTTT ATTCAGAATA ATAAATCACT CTTTATCATA 60

GTATCTTCTC TTCCCTCTTC CCCTTTAGTT TGGATAGCCT AACTCTGAGA AGTTAACCCT 120

TAAACAGTTT TCTGGAAGAG ACTGAATTTC TGGGTCCTTG CAGCTGTGAT GGTTTCAGAG 180

C T CAGACTG A TCAGGCATCA AGCTACCCTC AAGAGTTTCT GGGCTGGATG TTTCAGAACA 24 0

ACATCTACAC CAGTAAAGTG TAATAGGTCA GTTT CAAAAC GACCAAAAGA CCCCACCACT 3 00

CGAG 3 04

(2) INFORMATION FOR SEQ ID NO: 1122:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 88 base pairs

464

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(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1122:

GAATTCGGCC TTCATGGCCT AGTGAAACTC CATTTTTTTA CTGCTATTAC TCTGTGTTTT 60

CAGTTTTATG ATTTGGAATA CCATGATGGG AACATCTATA CTAAG CATTC CTTGGGGCAT 120

AAAACAGGCT GGATTTACTA CTGGAATGTG TGTCATCATA CTGATGGGCC TTTTAACACT 180

TTATTGCTGC TACAGAGTAG TGAAATCACG GACTATGATG TTTTCGTTGG ATACCACTAG 24 0

CTGGGAATAT CCAGATGTCT GCAGACATTA TTTCGGCTCC TTTGGGCAGT GGTCGAGTCT 300

CCTTTTCTCC TTGGTGTCTC TCATTGGAGC AATGATAGTT TATTGGGTGC TTATGTCAAA 36 0

TTTTCTTTTT AATACTG GTA ACCTCGAG 3 88

(2) INFORMATION FOR SEQ ID NO: 112 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 478 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID HO:1123:

AGCAATTCCA TAAACACATC CTGGTGTCAT CACAG CCAAG GTTTTTAGGT TGCTATACCA 60

ATGGCTTATT AAATGAAAAT GGCACTAAAA GTTTCTTGAG ATTCTTTATA CTCTCTGCCT 120

TCAGCAATCA ATTCCATTCA TACATCAGCA CTCTGCTGGT TCTGTTTGAA ATATGTTCTG 180

TATTTAAAAC TCAAATCTTG TTGGATCTCT GCAGGGCTTG TGACCAATGA AGTCATATTT 24 0

GTTGATGGTT GACAAAGCTT GCTTCACTCC ATCAGAGAAT GACTATCAAT TTTTTTTTAA 3 00

CTGTCCTATC ACGTCCTCTC CTGTCACCCA TTTTGAAGAG TGGCAGAACT TGAAGTTCAA 36 0

CTTCCTCTGT AAATATCCAA GTATAAAGCC CAGGAACTTC TAGAATAACC CAGATGCGCT 42 0

TTAATTTTTT TTAATATGTT TTGATCACAG AACTCCTTAG GCCTCTTTGG CCGAATTC 4 78

(2) INFORMATION FOR SEQ ID NO:1124:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 50 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1124:

GAATTCGGCC AAAGAGGCCT AGGAATTCAG TGCAAACACT ACTTTGAACT GTGGTTCCTA 6 0

ATTTCCACGA AAGTTTTTCT CTGTTCTTCT ATTATGGCAC TTTTCAGGGT CTCCCTTGTA 120

CATTTTAGTT TTTGTGTTTT TCAGTAAGTG CCTTGAGATC AGGGACCGGT TCTACTGGTC 18 0

TGTTCCAACC ATAGTTCCTT AAACATTGTG TTCCATTAAT ATTGGGTGAA TTGAAATGAA 24 0

TTTATAGGAA GCTCCTTAAC CTGGGGTCCT CAGACCTCTA TGGGGTCCAT GGACAGAATT 300

TGAAGTGGGA AGGATATATG AACTTGGATG GAGGAAAATT ACTTATTTGT TTTTTACCAA 36 0

CCTCTCCTTT GTAATT TAG C CATTTGTTCA ATTATAATGT AGGCAAATAA AAATAAAAAT 420

AAAAATAAAA TAAAGGCAGC TTAGGCCTCT 450

(2) INFORMATION FOR SEQ ID NO: 1125:

465

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(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 5B0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1125:

GAATTCGGCC AAAGAGGCCT ATCCTTAGTG GATTCCGACT TCCATGGCCA CCGTCCTGCT 6 0

GTCTATATCA ACCAACACCT TTTCTGGGGT CTGATGAGCG TCGGCATCGG GCGCCTTAAC 120

CCGGCGTTCG GTTCATCCCG CAGCGCCAGT TCTGCTTACC AAAAGTGGCC CACTAGGCAC 180

TCGCATTCCA CGCCCGGCTC CACGCCAGCG AGCCGGGCTT CTTACCCATT TAAAGTTTGA 24 0

GAATAGGTTG AGATCGTTTC GGCCCCAAGA CCTCTAATCA TTCGCTTTAC CGGATAAAAC 3 00

TGCGTGGCGG GGGTGCGTCG GGTCTGCGAG AGCGCCAGCT ATCCTGAGGG AAACTTCGGA 360

GGGAACCAGC TACTAGATGG TTCGATTAGT CTTTCGCCCC TATACCCAGG TCGGACGACC 42 0

GATTTGCACG TCAGGACCGC TACGGACCTC CACCAGAGTT TCCTCTGGCT TCGCCCTGCC 480

CAGGCATAGT TCACCATCTT TCGGGTCCTA ACACGTGCGC TCGTGCTCCA CCTCCCCGGC 540

GCGGCGGGCG 550

(2) INFORMATION FOR SEQ ID NO: 1126:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 81 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1126:

GAATTCGGCC AAAGAGGCCT AGTTTGCAGG AAGAAGG CAT GGGATAGTCT GAGAACAAAC 60

AGGCACTAAA TGG AG CAACA TCATCTTGAG GTGT CAAGCA GG AG CTGGGA GACCAGCAGA 120

GACTCCCAAG GCCTTGCTGC TGTTGGTCTG CAGG CAG CTC TGTAGGGCAG GCTGTTGTCA 180

TTTTGCAAGT GAG CAAG CAG AAGCCCAGGC AGGTGAGTCA TTCACTCCAC AGTTCATAAC 240

TTGGATTGTG GGTTAGTTAC ACCTGACTCC AAAACTTGAC TTTT TACTAC T CAGCTAT AC 3 00

TGGCCTCTCA AGAAAGGCTA GGCCCTAATT TCTAGACTCT CTTTTACCAA TAATACCTGT 360

TGCCACGAAG TAGGCCTCTT T 3 81

(2) INFORMATION FOR SEQ ID NO: 112 7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 361 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1127:

GAATTCGGCC AAAGAGGCCT ACTCTCAAGG TGGGCATATG CAAAACATAA TCTCTAAATT 60

CTTCAATACT AAGAAATACC TTTGTTTTAC CCCTAAAATC AAATG CCATT TTGGCTGGAT 120

ATAGGATTCT AGGATTAAAG CCTTTTTCCA GCAGAACTTT GAAGACATTG CTCCATTTAC 180

TTCTAGCATC CAGTGTGTCC AGTGATAAGT CTGCTGTCAA CCTGATTCTT GTTCCTTGGT 240

AGGTAATTTC TCTTCTCTCT CTAGAAGCCC TTATTATTTT CTCTTTATCA CTAGAATTCC 3 00

AAAATTTCAC CAAGATGTGT CTAGGAG TCA GTCTCTTTTC ATCAATTTTA CTAGGTACTC 360

466

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G

361

(2) INFORMATION FOR SEQ ID NO: 112 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 359 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 112 8:

GCAGCCAATG GCGGCGCCAG AGGGGAAACN GAGCCTTGCT NACGGGCCCA ACGCTGGGGA 60

GCAGCCAGGC CAGGTGGCGG GCGCAGACTT CGAGAGCGAG GACGAGGGCG AGGAATTTGA 12 0

TGACTGGGAG GACGACTACG ACTATCCCGA AGAGGAGCAG CTCAGTGGTG CCGGCTACAG 180

AGTATCAGCC GCTCTTGAAG AAGCCGACAA GATGTTTCTG AGAACAAGAG AACCAGCCCT 24 0

GGATGGCGGG TTT CAGATGC ATTATGAGAA GACCCCGTTT GATCAGTTAG CTTTTATCGA 3 00

AGAGCTTTTT TCACTGATGG TTGTCAATCG TCTGACCGAA GAACCCGGCT GCTCTCGAG 359

(2) INFORMATION FOR SEQ ID NO: 1129:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 274 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1129:

GATGGCACCC TCCTCAGAAA GCAGCGTCCC CT CTCACAGT ATGTCCTCCC GACGGGACAC 60

AGACTCGGAT AC CCAGG ATG CCAATGACTC AAGCTGTAAG T CATCTGAG A GGAGCCTCCC 120

GGACTGTACC CCTCACCCCA ACTCCATCAG CATCGATGCC GGTCCCCGGC AGGCCCCCAA 180

GATTGCCCAG ATCAAGCGCA ACCTCTCCTA TGGAGACAAC AGCGACCCTG CCCTAGAGGC 240

GTCCTCGCTG CCCCCACCCG ACCCCTGGCT CGAG 2 74

(2) INFORMATION FOR SEQ ID NO: 113 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 325 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 113 0:

GGCTTTCCAC
GGGTCATGCT
ACAAGCCTGG
GGAGAGAGTT
CTGTTCATTC
TGCCTGTCAC

CTTCCCTGCG GAGATGAGGG TGGTGGCCTC CCTTTTTGTC ACCCTTCCAA
CGTCTGCTGG CTTTTCTCCA AGATGCTGCC AAAAATGATC TTAA1 AAG AC
TTGTGATATT TTCCTGATTC AAGTGTCTCT GTGGTTCTTG GTTGCCTTCA
CAAGCCTCTT ATGGTGGTTT GTGAGGCCAG GCCTGAACTA GCCCCATCGT
ACCACCCCAG TATCCCTGCT GCAGGTTTTT AAAGATCTCA TGTCCCTGAT
TGTGTCTGAC TCGAG

60
120
180
240
300
325

(2) INFORMATION FOR SEQ ID NO: 1131:

467

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: €3 9 base pairs
{ B ) TYPE; nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1131:

CTCGAGGATC CCCGGGGACG GGACGGGCCG GGGCTTGGAG GGGGGTCGGC TGCCACAGGC 6 0

TCACATCACG GCCTCCATAT GCAGGATCCT CAGGGCCTCG GAGATCTGCG CGCTGGGGTC 120

CATCTGGCCG TACATGCCCA CCAGGAAGGC CCGGTGGAGC AGCACAGCCG CGTGCTCTTG 18 0

GCACAGGAGA GCGTACTCAG GCAGGTTCCG GAGGGCCGTC TGCACCACCT CAAAGTCCTG 24 0

GCTGCCCAGG CAGTACATGA ACGTNGGGCA GGAAAGCGGC TGCAATGCNG GGGGCTGTCT 300

GCATGGAGCG CAGGGCCAGG CTGAAGGCGA GGTTGCGGCA ACACTCCTCG GCCGAGCTCA 360

TCAGCCGCTG CAGGTTGGTC GAGAAGAAGC TCAGGATCTC GGGTCTCCGC CGGGACATCT 420

CGTCTATGTC ACTCAGAACC T CCAGCAG AT CCTCCACCGT TTGGCCCCGG GAAAGC CGTT 4 80

TCATG TAGGG GGCCATCTCG GCCGCGGTCA GAGGGGTGAA CAGGGAGACG CTGACCAGGG 54 0

GCAAGGAGCC GGCTGAGCTC TCCTCCTCGC CCTCTTCGTC CAGGCCTCGG TCGGTCCTGT 600

CGTCCCTGCT GGGCAGGCTG AGCCCTGCAA GGAGGGATC 63 9

(2) INFORMATION FOR SEQ ID NO: 1132:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 8 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY j linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1132:

GGTCTGTGGT CTTGGAGGCT TAAATTGTAA AATACATCCC TTATGGAATC CTAAATTCCT 60

CTAGGTGTTT TTGGAAGGCG CATTTGAGCC TTGTG AG CTA AAATGGAATG GATTTAATAT 120

TTCCTATCTG GCATTTCCAT CTTGCCCCTG GTACACAAGT CACTGGCCTG GAACTCAGCC 180

TTGATTCACT GTCCGTCTTC ACGGATTAGC TGTGCTGTTA TGTTGTCTGT GCTGCAGATT 240

GGCCCATGTG GGAAGTCGGG GGGGACCTGA TTTCCTGCTT GGAAGACTTG GGGGACTGCC 300

GAG CAT ATCA AAGTGTTTAT AGTCACCAAG TGAACTGCAG CACAACCATC TCCTCTCCAG 360

CAAGCCCTGA AGTCAGTAGT GCCTGCAGGT GAAACCAACC AGCCCTGTGT TAGAGGAGGA 4 20

AAAG CGGAGA TGACGTGGAA GTCTCGAG 44 8

{2) INFORMATION FOR SEQ ID NO: 1133;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 72 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1133:

GAATTCGGCC TTCATGGCCT AGGGCTATGG CCGGAGCTTG AGATACG CCG CTCTGAATCT 60

TGCCGCCCTG CACTGCCGCT TCGGTCACTA TCAACAGGCA GAGCTCGCCC TGCAGGAGGC 120

AATTAGGATT GCCCAGGAGT CCAACGATCA CGTGTGTCTC CAGCACTGTT TGAGCTGGCT 180

TTATGTGCTG GGGCAGAAGA GATCCGATAG CTATGTTCTG CTGGAGCATT CTGTGAAGAA 24 0

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GGCAGTACAT TTTGGGTTAC CGAGAGCTTT TGCTGGGAAG ACGGCAAACA AGCTGATGGA 3 00

TGCCCTAAAG GACTCCGACC TCCTGCACTG GAAACACAGC CTGTCAGAGC TCATCGATAT 36 0

CAACATCTCG AG 372

(2) INFORMATION FOR SEQ ID NO: 113 4:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 52 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 113 4:

GAATTCGGCC TTCATGGCCT AGCTGGTTCT TTTATTTTGG TGTCTCAGGG ATGTAAAAGA 6 0

TTTTTAGTGC ATAATATTAA ATGG CAAAAT CAAATTTCCC AACAATATAC AAAATAAAAT 120

CCCATTTACA AAGGGAAAAG GCTTTATCTA TTTGTATATC TTCTTATATG TATATAAATT 180

CATAGAAAAC TATCTGGAAG TGTATGTAGC AAAGCATTAA CAATGGTTAT CTCTGGGTAT 24 0

AAGAAGGAAC TAGAACTGAA GAAGATGGTG GTGATAAGGG AAGGTATACC TTTCTTTTTT 3 00

TTTTATTCTG CTGTGCTTGA GTTTTAAAGA ATGAGAATAT TCATGTATTC CTTGTATAAT 36 0

TATAACACAG AAAACCTCCT TATTAGGAAT AGGAGGCTGA TTTCTTTTTT AATGACTGAT 4 20

CTTAGGTCCT TTTTGGGTAT TTCTCCCTCG AG 4 52

(2) INFORMATION FOR SEQ ID NO: 1135:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2B3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:ll35:

GAATTCGGCC TTCATGGCCT AGGAGGAGGG AAGGATTGGG AGCAGTGGGG TGTGAGTGGG 60

AGAGGAGGTA GGGAACCAGA TGGGGAGAAT CGAGCCAAGT TCTGGGTTGG AGGAAACTTT 120

CTTATTTAAC TGAGCTGGTG GGTTACATAT CTAATGTTGC AGGTGATGAA TACAGGCTGG 18 0

GGTAGCCGTC TAAATCCACC GAAAGAAGTA AATGAAAGTG GTTTCTTGTA GGTCGAAAGG 24 0

TCAAGGTAAA TGGCTGGTTT TTAGGAAACA ACTGATCCTC GAG 2 83

(2) INFORMATION FOR SEQ ID NO: 113 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1136:

GAATTCGGCC TTCATGGCCT ACTGGAGACT TGTAATTAGT CTAAG CATAA TATGATTAGG 60

TGGATGAAAT ATTTTGGAGT TTGGTTTTGT TTTAAATGTA AATACTCATG AAAAGTAAAA 120

CATACTGCAC TGTGTCCCTG GGAATATTTT TGTTATCTTT AAAATACTCA GTATTATAGG 18 0

CATTTATTAA CACAGCCTTA CATTTGCCCG GTTTGACCTG GAGGCCGAAA TGAATTGTGA 24 0

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CTTATGTCCC AGCTGGGTCT CGAG

264

(2) INFORMATION FOR SEQ ID NO: 113 7:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 6 53 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 113 7:

GAATTCGGCC TTCATGGCCT ACCACGTTTC CTCACCTGTA AAATG GAC AC TGCAG CTATG 6 0

TCTGCTGTTC CACATTGTTG ATAGAACTGG ATGCTGTGGT GACATTTGGG ' ACACTATCAT 120

GGTGCCTGGG GTGGGTGGGT GCCCAGGCCT GTGGGCTTCT GTCTTTCATC AAAGAACTTC 18 0

AGATCCCAGA AAATTAAGAT TCTCAAAACA TAACTGTCGG AAAGGGCTTT TGAATCCACC 24 0

TTGGTGGCCT CTTCCTGCCT CCAGGGCTCA TGAGATAGGC TGACTTCATA TGAAAGTTTT 300

GAGGATGAGG AAGTCTCTCT CCTCTTCAGA TACTGACCCT CTCTCTCCTT ATTTCCTTGG 3 60

TGCCCAGAAT AGGGCTTTGG TTATCTTGAA TGAATGAATA TAAACTCACA GGTGTGATCT 4 20

GAGCCACCTA AAGCCCTCTT TGGGTTCTGC TCAGCTTGAG GGCATCACCT AAAGGCCACT 48 0

GGCTGCATTT TCCAGGAGGT GTTTTCTAAG CTGTATCTAT ATAGGAATGG GGAGGAAAGC 54 0

TAAGTCATTG TAGACTGAGA GAAAGGGAAT AAGAGTCTGT TCCAGACCAG CTAGGGCTGA 6 00

CAAGCTTAGG CAGCTGGGGG CAGAGGGCAC TGAGAATGAG GCCCTAGCTC GAG 653

(2) INFORMATION FOR SEQ ID NO:1138:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 113 8:

(2) INFORMATION FOR SEQ ID NO: 113 9:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 04 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1139:

GAATTCGGCC AAAGAGGCCT AGTTAATACT TATTTTATTT TCTGTTTTTA TCATCTAGTC 60
AACTCGCAAA CT TCCAG CAT TTGTCTAAAT CTAC TCAATA TATTCCAGTA CATCAGATAA 120

GAATTCGGCC
AAAGATCTTC
TCTGTATTAG
CAACAACAGC
GACCTTCCTC
ATCACCATTC

TTCATGGCCT ACAAAAGGTT CTTGATGACC ACCACAATCC TCGCTTAATC
TGCAAGACCT AAGCTCTACC CTCTGCATTC TTATTAGAGG AGTAGGGAAG
TGGGAAACAT CAATATTTGG ATTTG CCG AT TAGAAACTAT TCTCGCCTGG
TACAGGATCT TCAGATGACT AAGCAAGTGA ACAATGGCCT CACCCTCAGT
TGCACATGCT GAACAACATC CTATACCGGT TCTCAGACGG ATGGGACATC
TCGAG

60
120
1B0
240
300
315

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TATATCAGTT TCATCCTCCT GAAAAACTCT TTTCCAGTGT ATCCTGACCT GCTCTAATTT 180

TGACTTGATG CTTTCTGTAT CTGGTGCACA GCTGTTACCT TGGAATCTTC CCTTCATCAT 24 0

TATTCAGAGT GTTTCTGTAG TTTTTCTCTT GCATTGGATT TTGTGCTTCC TGAATCCTCT 3 00

CGAG 3 04

(2) INFORMATION FOR SEQ ID NO:- 1140:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 303 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 114 0:

GAATTCGGCC AAAGAGGCCT AGGGTTTTGT TTGGTTTGGT TTTAGTTTTT TGTGGGAGAA 6 0

TTAAGATTTT TTAAGAGATA TTTTCAGATT TTTCTGTTGT CAGTTTTGGT AATTTGTGTC 120

TTTTAGGAAA ATTTCATTTC ATCCAAGTTG TTGGATTTAT TGGCATAAAA TTTTTCAGAA 180

TATTCCTTTA ATATCCTTCT AATGTCTGTA GAATCTAATC TGTATTGCAG TCTCTTCATA 24 0

TTGGTAATTT GTGTTTTTTC TATTTTTTCC TGGATCAGTC AGTCTAGCTG GGGAGAACTC 3 00

GAG 3 03

(2) INFORMATION FOR SEQ ID NO: 1141:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 330 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1141:

GAATTCGGCC AAAGAGGCCT AGTAGCTTAG TTATTGTTTA CTTTGAAGCC CTTTTGCCTC 60

TACTCTCTCC CATATATCTT CT C CTGACAG GGTGAAGTCA CCTATAGCAT TTCCTAGTGT 120

ATGGAAGTAT TAATTTCTTT CTTTACTGGA AGAGCTACTA GCTTTTCTTC ATACAGTTTC 180

CTCTGCTCCA GTTTCATAAG TTTCTTTTTG GCTTGTATCT GTTTAGGATC AGGTGATATG 24 0

GCTTCATTTC T CATGACTG A AGCCCGGCAA CATAACACTG AAATTCGAAT GGCAGTCAGC 3 00

AAAGTGGCTG ATAAAACGGA TCATCTCGAG 3 30

(2) INFORMATION FOR SEQ ID NO: 1142:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 2 94 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1142:

GAATTCGGCC AAAGAGGCCT AGAGGGG AG C CTGGCCTCTG GCATATTCAT CAAGTATGAG 60

TTCTGGGGAT GAGTCACTGT AATGATGTGA GCAGGGAGCC TTCCTCCCTG GGCCACCTGC 120

AGAGAGCTTT CCCACCAACT TTGTACCTTG ATTGCCTTAC AAAGTTATTT GTTTACAAAC 18 0

AG CGACCATA TAAAAGCCTC CTGCCCCAAA GCTTGTGGGC ACATGGGCAC ATACAGACTC 24 0

471

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ACATACAGAC ACACACATAT ATGTACAGAC ATGTACTCTC ACACTCCAGT CGAG 2 94

(2) INFORMATION FOR SEQ ID NO : 114 3 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 331 base pairs

CB) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1143:

GAATTCGGCC AAAGAGGCCT AGTTTTAGTT CAGAATAACA TTAATTTTGA GAGATTGAGG 6 0

TAAAGAACCT TAACTAATGC TAAGGAGTTT ATTTTGATTA ACATAGGTTA TTCTGACCAC 120

CACCTCTTCC TTCCTTAATC TCCTTAGAAT CTGACAGTCT CAAAGCTGTC ACACAAATTA 18 0

GACTAATTTT GACACTTTGA AATGAAAACT TCAAGGAAGA AGTAGCCACG GACAGTTATG 24 0

TTTATAATCA GTAGGTGGCA CTCTTTCCTC AGGTAGCCCC CCATTTTCAC ATGATGTGTT 3 00

TGAAGGTTAA ATGCCACCAA AAGTGCTCGA G 331

(2) INFORMATION FOR SEQ ID NO: 1144:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 50 8 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi> SEQUENCE DESCRIPTION: SEQ ID NO: 1144:

GAATTCGGCC AAAGAGGCCT ACTTCAGCAT GACTACTCAG TTGCCAGCTT ACGTGGCAAT 60

TTTGCTTTTC TATGTCT CAA GAGCCAGCTG C CAGGACACT TTCACTGCAG CTGTTTATGA 12 0

GCATGCAGCG ATATTGCCCA ATGCCACCCT AACACCAGTG TCTCGTGAGG AGGCTTTGGC 180

ATTAATGAAT CGGAATCTGG ACATTTTGGA AGGAGCGATC ACATCAGCAG CAGATCAGGG 24 0

TGCGCATATT ATTGTGACTC CAGAAGATGC TATTTATGGC TGGAACTTCA ACAGGGACTC 3 00

TCTCTACCCA TATTTGGAGG ACATC CCAGA CCCTGAAGTA AACTGGATCC CCTGTAATAA 360

TCGTAACAGA TTTGG CCAGA CCCCAGTACA AGAAAG ACT C AGCTGCCTGG CCAAGAACAA 420

CTCTAT CTAT GTTGTGGCAA ATATTGGGGA CAAGAAGCCA TGCGATACCA GTGATCCTCA 4 80

GTGTCCCCCT GATGGCCGTT CGCTCGAG 508

(2) INFORMATION FOR SEQ ID NO: 1145:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 61 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1145:

GAATTCGGCC AAAGAGGCCT AAATTGCTGG CGGATTTAGA CCGGTAGAAA ACCCGGGATG 60

GTTTATTTTG ATTGAGCCCC CTCTGGGTGG CAGAGAGGAG GCTTGGGCTC TGGGCCCTTT 120

ACGTTTGGAG AAATGGCTTT ATCAG CTCAG TTGAAAGGTT TTTCCCTCTA GCTAGTGAAA 18 0

GATAAACTTG GAAATGCAGG TTTCTCCAGC GGTTGG TGGT GGGGACAGGG GTCGCCTAGG 24 0

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GAACTTGCAG GGGCCGCGGC CTCTGTTGTG CTCTTCTGGA GAG TGCAC TG TTTGTGGAAC 3 00

TTTTCTAGAG TGGCAAAAAC GATCTCCACT G T CGGTG AAA GGGCAGTTCC TGAAGTCAGC 3 60

TCATGGTCCT GGCTCCCCTT CTCCCCAGCA GTGAACTGGG GGTGACTTCC TGATCTGCCC 420

AG CACAGG AG AGCCCCGCAA AGCGCCTGGG AGGCCCTCGA G 461

(2) INFORMATION FOR SEQ ID NO: 1146:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 291 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 114 6:

GAATTCGGCC TTCATGGCCT ACCATTTTGG ATTGATTTTT GTGTATAGTG TAAGATGAAC 6 0

CCAATTTCCT TCTTTAGCAT GTGGGAATTC TGTTTTTCTG TCACCCTTTT TTTTTGAGAT 12 0

GGGGTCTCAC TATGTTGCCC AGGTTGGCCA TGAACTCCTG AGGTCATGTG ATCCTCCTTC 180

CTCAGCCTCC TGAGTAGCTA GGACTACAGG CATGTG CCAC TGTGCCTGGC TCCAG CAACA 24 0

GTTGTTGAAG AGACTGTTCT TTATTTACTT ATTGTATCCT CTGTGCTCGA G 2 91

(2) INFORMATION FOR SEQ ID NO: 1147:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 114 7:

GAATTCGGCC TTCATGGCCT ACCCACCTGC CCACGCCGAC TTGGGAGGAT GGTGGCCTGC 60

AGCGGCCAAG AAGCCAAAAA AAAAAATTTT TTTTTTTTCA GATACTGTGC TTGATTTTTG 120

GAGAGGGGAG AGGTGGAAAT TCCTAAATGG CTAATGCACT GTTCCCTCCA GCCCGAATGC 180

CTCCTGCCAA ACCCCTTTTC CCTGCTGCCT CTGTCCCCGC ATCCTTGTTC TCCCCTGGGT 24 0

CCGAAACATT TTTTCCGAGG ATGAACAGGG GACATCTTTA GGTTTCTCAA CTCTTGCTTT 3 00

GGTGTTTGCC GCAG CATGGA AAACAGGCAC CCCTCGAG 33 8

(2) INFORMATION FOR SEQ ID NO: 1148:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 85 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1148:

GCAGGAATCA GATTCACTCA TTAGTAAGCC GCACTCGCTG AAGGGGAGAG CATGAG CAAG 60

GCAGACGTGA GCCACTGCGC CCGG CCTGAA GAGTTTTTGC TAATTGGATA TTAGGGAAAA 12 0

CCACAGGATG GATTAAGACA AGAGAGGGAA GGTAAGGTTC TAGACAGCAG GATTATGTCT 180

GTTAGTTGGT TTTATGTCAC TTTTCTAGCC AAGCTGTACC ATCCTGTTTT TGTTGGTTGG 24 0

TGAATGCTTC CAGCTCTTTT CCTCCAGCCC TTGGAAGAGG TGGTCCTATA ATTGTTAAGC 30 0

473

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ATCTAGCTAG GGTGATGAGT AGGAATAGCA ATAAGTGACA GGGAAGTTGA AGGCTGCAGG
GCTCTTTGCA GGCGGCTTAC TCGAG

360
385

(2) INFORMATION FOR SEQ ID NO: 114 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 303 bas<= pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
.(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 114 9:

GAATTCGGCC TTCATGGCCT AGT CACATG A ATGAGAGAAT TCTAAATGCA AGAAATGTGC 60

AAAGGCACAG AAACACAGAA GAG CATGTTG TACAACCTGG CTATAGTTTA GATTTTGTGT 120

GTGTGCTATG AGAGTGTGCG TGTGCTGTGA GTGTGTGTGT GGGCGCACGC ACGCATTTGT 180

AGGAGGTAGG GAGAAGAGTG CCGG CATAAC ATGAAATGAT ATTGGACCTC AAATGGTATG 24 0

CTAAGATGTT TGACAATTTT ATTCTAAGCA GTGAGTTTTT AAATTTAGAC ATGCAATCTC 3 00

GAG 3 03

(2) INFORMATION FOR SEQ ID NO: 1150:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 419 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1150:

GAATTCGGCC AAAGAGGCCT AATTGAATTG TATTGGTCTT TTTCTCTTTA ATATTTTAGG 6 0

TGCTTTATTA TATATTAGGA TTATTAGTCC TTAGTTTGTG AAATAAGCTG CAAATATTTT 120

TTCCCCAATT TTTCTTTTGT CTCTTTGCTT TATTTCTGGT GTTTATTTTT CCCCAGGTGT 180

ACTGTTTTCT ATAGCCAAAT TATTGATCTT TTCTTTAATT GCTTTTTTGT TCACTCAAAG 240

GAAGGTTTTC ACCACTGAGA GGTTATAAAA TAATTCACTC ATATTTTTAC TCTTTTTTTT 3 00

TG CTTATGTT AATTTTT TGT TTGGAACAAT CTCAAATTCA CAGAAGTGTT GTGAGTACGT 360

TGCAAATAAC TTGTTTTTTC CTTATG CATT TCAGAGTAAG TTACCAGTCC GCGCTCGAG 419

(2) INFORMATION FOR SEQ ID NO: 1151:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 94 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1151:

GAATTCGGCC AAAGAGGCCT AG CGGATGGA GTCTTTGACA GTGTTTTTGA TCTCCTGCAG 60

ACGGCTGCTC AGGAAGCTGT TGACC CGATC CAGTTCCCGG TCGGGCCACT CCAAGAGCCT 12 0

CTCCCTGGCA GGCCTTGGCT CCCGGCTTCC AGAAACACGA TTTGCCTGCT TTAGAGCTTC 180

TGCTGCCAAC TGGGCCTTCT CCTTTTCCTT CTTTTTCAGC TTGTGCCGGG CCCGCTTGGC 240

GGCCCTGGCG CTGTTGGGGA CTTTGGGCTC CGTGCTGTTG ATG AATT CCA GCAGCTCATC 3 00

474

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CACATCTCGG TGGTCCACGG CGGGCTCCCC AGGGATCCCG CCCAGGGTGC CCCCCTTCAT
GGGCAGCTCC TCTTTCCGCC TGGTCAGCCT CGAG

360
394

(2) INFORMATION FOR SEQ ID NO: 1152:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 426 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1152:

GAATTCGGCC AAAG AG CCT A CTGTGAATCA CGAACTGGCT GAGGGCGGCT GACCGCTTGT 60

AGCTGTTCCG GCCATGCACC ATAAGAACCG GCCAAGATGC TTAAATTGAG TGATGGAGAA 120

GTCTGCAGCC AACGAAGCCT GTTTTCCTTC CTTTCCTTCC ACTCCCACGC CGCAGTCAGA 180

TTCCTGAATC ATGCTGACGT CATTGCCTCC GTCCCCTACT GCACAGGTGA GCTTGCCCGT 240

GCGCTCCTGA AGCAGGCGCA CGATCTGGGC CTTCTGGGTG GGGGCACATC NGCAGCAGAC 3 00

TACGGCCGGG CACTGGCAGG CCAGCTCCAT GAACTCGTAC TCATAGTACT TGAGGCAAAC 3 60

CTCCAGGGAG TCTCCCGAGA TGACCAGGGC ACAATCATGC TTCCTGCGGA AGGCGTTCAG 4 20

CTCGAG 4 26

(2) INFORMATION FOR SEQ ID NO: 1153:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 70 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1153:

GAATTCGGCC AAAGAGGCCT AAGCTGATAT TTATTGGACA TTTGCACCAT GCCAAGCATT 60

CGGCTTGGAT TAT CCCATTT GTTTCTCACA GCCGGTATTT ATTGTCTGCT CCTCTGTGCC 120

AGGTGCTGTG CTCTGGGCAG GGGCACTGCA TGGGCTGCCT GCCCTGGTGG AGCTTGTGGT 180

CTGATGGGTG AGGCTGACCC AAGCCCACCC CATTGCCAAC AGGGCCAGGG CAAGAGTACA 24 0

CACAGGGGCC TCATACCATA TGTCCTCGAG 270

(2) INFORMATION FOR SEQ ID NO: 1154:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1154:

GAATTCGGCC AAAGAGGCCT AGCTGAAATC ATTCTGAAAA CTCAAACAGT AGACTTCAGC 60

ACACAAGGAA AG CCAAAG CC ATTTGAGGGG GAATAAAGCC AAAAGCCTTT CACCTTATTC 120

GTTCCAAGAA TCTCACCGCC CCCTCCTTAT CCCCCTCCAA AAATAAGCCA TTGCACACAG 180

ACAGGCAGCA TGGCTAGCAA ACGAAAATCT ACAACTCCAT GCATGGTTCG GACATCACAA 24 0

GTAGTAGAAC AAGATGTGCC CGAGGAAGTA GACAGGGCCA AAGAGAAAGG AATCGGCACA 3 00

475

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CCACAGCCTG ACGTGGCCAA GGACAGTTGG GCAGCAGAAC TTGAAAACTC TTCCAAAGAA 3 60

AACGAAGTGA TAGAGGTGAA ATCTATGGGG GAAAGCCAGT CCAAAAAACT CCAAGGTGGT 4 20

TATGAGTGCA AATACTGCCC CTACTCCACG CAAAACCTGA ACGAGTTCAC GGAGCATGTC 4 80

GACATGCAGC ATCCCAACGT GATTCTCAAC CCCCTCTACG TGTGTGCAGA ATGTAACTTC 54 0

ACAACCAAAA AGTACGACTC CCTATCCGAC CACAGACTCG AG 582

(2) INFORMATION FOR SEQ ID NO: 1155:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1155:

GAATTCGGCC TTCATGGCCT AGGATCCGTG AGGGAGACCG CATCATCCAG ATTAACGGTG 60

TAG ACGT CCA GAACCGGGAA GAGGCGGTGG CCATCCTGAG CCAGGAAGAG AACACCAACA 120

TCTCCCTGCT GGTGGCCCGA CCTGAGAGTC AG CTGGCGAA AAGGTGGAAG GACAGCGACC 18 0

GGGATGACTT CCTGGATGAC TTTGGCTCTG AGAATGAGGG GGAGCTGCGT GCTCGTAAAC 24 0

TGAAATCACC CCCTGCCCAG CAGCCCGGAA ACACTCGAG 279

(2) INFORMATION FOR SEQ ID NO: 1156:

<i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 353 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1156:

GAATTCGGCC AAAGAGGCCT ACATTGTTAA TATAATTTAA CAGAAGTTGT GAAACTAAAA 60

TTTTCTAAGA TTAACTGGTA GTTCATTGTA AATGAACATA ATGAACAGAA TTTATGACTC 120

CACTGTGGAA AATGCTATCA AATAAC TAAG GAATATATAT GGAATAAGTG TACATATGTA 180

AAATATTGTT ACTAG AG TT A GATATGTGCC AAAGTCCATT TAT C CCAAAT CCTGTCTGAA 24 0

AAGGAGGGGT ACATTGGTAA ACATTTTGGA GTGCTTAAAA ATGCCAAAAA CAAAATGGTA 3 00

ATTTCTACTT TGATAAAGTA AAAAAGTTAA ATGTGTGTAA AAAAGTGCTC GAG 3 53

(2) INFORMATION FOR SEQ ID NO: 1157:

U) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 331 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
<D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1157:

GAATTCGGCC TTCATGGCCT ACGGTGGCCT TTGGGGCCGA AGTGGGCGTG CGGCTCGCGC 60

TGTTCGCGGC CTTCCTGGTG ACGGAGCTGC TCCCCCCGTT CCAGAGACTC ATCCAGCCGG 120

AGGAGATGTG GCTCTACCGG AACCCCTACG TGGAGGCGGA GTATTTCCCC ACCAAGCCGA 18 0

TGTTTGTGCG TGGAGAAAGA TCGTCTTTCC TCCCTCCCCA TGACCGGGCT TCCCGCGGGC 24 0

476

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ACCTGTGCGT TTTCCACCCC GAGACGGCCT TTGTAGGGAC CCACTGCCCA CTCCGCTGCT 3 00

GTGCGCTGGG TTCCGCCTCC TAGGGCTCGA G 33 1

(2) INFORMATION FOR SEQ ID NO: 1158:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 17 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1158:

GAATTCGGCC TTCATGGCCT AAAAACTTAG ACTGACATCT AGCTTTGACA ATCATAG TAT 6 0

GTTTTATTTT CCTGAGGGGG AATAACTTAT AATGCTGTTT AGTTTTGTAC TATTGGTGTG 120
TTGGTGAATT TTTAAACTGT GTGCTAACTG CACGATTGAA TTCTAGACCT GCCTCGAG 178

(2) I N FORMAT I ON FOR SEQ ID NO: 115 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 401 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1159:

GAATTCGGCC TTCATGGCCT AAGCACTTTG GGATGTTGAA GTGAGGGGAT TGCTTGAGCC 60

CTGGAGTTCA AGACCAGGCT GGGCAATATC GCCAGACCCC ATCT CTTAAA AAAAGTAGTT 12 0

CTTTACTGTT GCCTCTATTG ACTCTTGAAT GCAAGAAAGA ACATTTGCCC TTTGACTTCT 180

AATATTATCT TATATTCTCT CTTCTTCAAA AGATCAGAAG CACATGCTGT AAACATCAAT 24 0

CATGATCATC TTTGTCTCCC TTATCAGATT GTCAAAATTA TATCTTTTCC TATTTTCCTG 3 00

CATACCT TAT CTTTTTCCTA AATTCTCAGT TCTCCAAGTT CTCAGAAATC ATAACTTCAG 360

ACCTTGAAAT GATGACTCTG TTCCACCCCC ATCGTCTCGA G 401

(2) INFORMATION FOR SEQ ID NO: 1160:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 50 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:1160:

GGGGGGCCAG ACACGCNTGG GGTAAGAAGG GCCTGGTGGG AGGAGTTCAC AGAGCAGACG 60

GTGCACTGGG ACCAGGAGAG CAGAACACAG GCCATAACTA TAGGG CAGGT GGGGCAGGAA 120

CGGGTTAAAA ACGAGATCCA AG C CAGCCAG ATCGCAGGAG GTGCGGGGGC GTCGTCCCCC 180

TTCTGTTCTC CCCCCAAGGT CACAGTG CAT GCAATAAAAT ATATATACAG GAG CTAGAT C 24 0

CGTCCTCTGC AGGGGCTCTG AGGGTCCAGA GCTCCCTTCG GGTGGCGGGA AGCCAGTGGC 3 00

GCTCCCTGGC GGCCAGGCCG GGCTGGAGCC ACATG CGTCG GGGTCTCGAG 350

(2) INFORMATION FOR SEQ ID NO: 1161:

477

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 597 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS ; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION ; SEQ ID NO: 11.61:

GCCCCGGAGC ATC TTAAGAG CTGAGCGCAG CTGACAACTA GGGGCCGGAC CGTCGCAGGA 6 0

GGCGTCCGCT GGATACCTTC CCCCTTCCCT GACCTAGAGC TCTACAGCTG CTGCCTCGGT 120

ACTGACCGAG GGTTCCCAGA GCTGTCTCAC C ATTG CAAAA ACGTTATAGC AACAGCCTCT 180

GATTACGACA TGG CTGAGAT CACCAATATC CGACCTAGCT TTGATGTGTC ACCGGTGGTG 24 0

GCCGGCCTCA TCGGGGCCTC TGTGCTGGTG GTGTGTGTCT CGGTGACCGT CTTTGTCTGG 3 00

TCATGCTGCC ACCAGCAGGC AGAGAAGAAG CACAAGAACC CACCATACAA GTTTATTCAC 360

ATG CTCAAAG G CATCAG CAT ATACCCAGAG ACCCTCAGCA ACAAGAAGAA AATCATCAAA 420

GTG CGGAGAG ACAAAGATGG TCCTGGGAGG GAAGGTGGAC GTAGGAACCT GTTGGTGGAC 4 80

GC AG CAGAGG CTGGCCTGCT AAGCCGAGAC AAAGATCCCA GGGGGCCTAG CTCTGGATCT 540

TGTATAGACC AATTACCCAT CAAAATGGAC TATGGGGAAG AACTAAGGAA CCTCGAG 597

(2) INFORMATION FOR SEQ ID NO: 1162:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 76 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1162:

GAATTCGGCC TTCATGGCCT AGAAATAACT TAAAATC CTG AATCAGATGT TTCTCCGTAC 60

ATGGCCTATC CAGATCACCG TAGGGTGAAG CTCAAAGTCA GCAAGCCTCA CCCACATACT 120

CAGAGCTTCC TTTCAGTGTT GAGACCTTCT TCCCTCTGAG CAGATGACAA AGGAGTTTGA 180

AACCAGCCTG GCCAACATGG TGAAGCCCCG TCTCTACTAA AAACACAAAA ATT AG CTG AA 240

ATGGTGACTG TAATCCCAGC TACTCAGGAG GCTGAGGCAG GAGAATCGCT TGAATCCGGG 3 00

AGGCGGAGGT TGCAGTG AG C TGAGATCGTG CCATTTCATT CCAGCCTGGG CAACAGAGCA 3 60

AG CCATCACA GATTTGGGAG CAACCAAGAA AG C CAGGGAC AGGGTATGCT TGGTAACCTG 42 0

GCAAGAGCTG ACAAAGGGGA AAAATAAAAC CCCACAGAAA GAGCAGGGAA CTCGAG 476

(2) INFORMATION FOR SEQ ID NO: 1163:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 82 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO-.1163:

GAATTCGGCC AAAGAGG CCT AGATGAACAT GAACCTGCGG GAGCTGTACC TGGCGGACAA 60

CAAGCTCAAC GGCCTGCAGG ACTCGGCCCA G CTGGGT AAC CTGCTCAAGT TCAACTGCTC 120

CCTGCAGATC CTGGACCTCC GGAACAACCA CGTGCTAGAC TCGGGTCTGG CCTACATCTG 180

CGAGGGCCTC AAGG AG CAG A GGAAGGGGCT GGTGACCCTG GTGCTGTGGA ACAACCAGCT 24 0

CACGCACACA GGCATGGCCT TCCTGGGCAT GACACTGCCG CACACTCAGA GCCTGGAGAC 3 00

478

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GCTGAACCTG GGCCACAACC CCATCGGGAA CGAGGGTGTG CGGCACCTCA AGAACGGGCT 36 0

CATCAGCAAC CGCAGCGTGC TGCGCCTCGG GCTGGCCTCC ACCAAGCTCA CGTGCGAGGG 4 20

CGCGGTGGCG GTGGCGGAGT TCATCGCTGA GAGCCCCCGC CTCCTGAGAC TGAACCCTCG 4 80

AG 482

(2) INFORMATION FOR SEQ ID NO: 1164:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 4 94 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1164:

GAATTCNGCC AAAGAGGCCT AAGGAGCGCT GTTAAAGCTG ATACATTCCT GTGGGTCAAC 6 0

TATG CAACTA ACTCAGATTT TGAGCAAACA AAGCTCTCAA GTTGGTGATC CTCAGGAGTC 120

TCTGCATTAG TTGGACAGCT CTTCTGGAAT TATCTTCTAA GTCAACTGTG GGTTGGGTAG 180

GTGGCTCTGC TGATTTTTCG CTGGACTTCC ACATTTGGGA CCAGTTGGCT GTNATCAGCT 24 0

CTAGAAAGGG TGTGGCTGTT TTACATTGGC TGTTTTCCTC ACATTCCTCA AGCAGGTACT 3 00

GTAATAAAGA ACTGGAGAAA TACAGTCAGA TGGGAAG TAG CCCCTGCTGT CAAGGAG CTT 3 60

GCCATCTAAT GGGGGAGACA GGCAAGTAAA CCAAAGACTA CACAGTGCAG TATGGTAAGT 420

GCCATGATTT TGATGTGACA GGGCACAGTG GACGACCTTC CAAATCAAAG CAAGTAACTA 4 80

GGGG CAGACT CGAG 4 94

(2) INFORMATION FOR SEQ ID NO: 1165:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH; 298 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:116S:

GAATTCGGCC TTCATGGCCT AACTCTTATC TGTGAACACA ACTTTTCAGC ACTACAAATG 60

CAAGCAACTG CGCAGTCACA GTTGGGGCTG CTAATTTGGA AATCCAGTTT AGGCTGATTT 120

GAAAAGACAA CAGCATTTTT GCAATCACTG GTGTATCCTT TACGAGAGAG CTAGTCATGC 180

CATTTTTTGT TTTCTGAAGA CGGCCTTTTT TTCTTTTTTA TTATTATTAT TTTTTTAAAT 24 0

TTGGGATCTT GCCTAATTCT TTAGTACAAA GCCTGGCCCT AAAACCGTAG AGCTCGAG 298

(2) INFORMATION FOR SEQ ID NO:1166:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 266 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1166:

GAATTCGGCC TTCATGGCCT AGATAGAAAA GAATATTCCA AG TGTATGAA GTATAGAGGT 60
GGGGAAGTTC AGGGTAGAGA AGTANTAGCA GGAATAGAAT ATAGGGGGAC AGAAAAATAG 120

479

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AGTGGAGCCA GATTCAGAGA ACTTTNAGAA GCAGGTAAAG AAGTTTAGGA TTAATGGACA 180
AGTCATTGGG TCTCCAGGTT TCTTTGAGGG AG AG TG AT AT CTGAGCTCTG TTTTAGAAAG 24 0

ATTAATCTGA AAGGAGGTAA CTCGAG 2 66

(2) INFORMATION FOR SEQ ID NO: 116 7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 499 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
(0) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 116 7:

GAATTCGGCC TTCATGGCCT AGGTAAATAA TGCCAAGTTA CTGGGGTCTA GAAAGAAAGT 60

TTTCTCTTGG AT CAAGAG AG TGTGAGTTTC CTAAGTTTCT TCAGCAGGGA TGTTGGTCCT 120

TTAGTTAGGA GGTTTAAAAT CACCAGGAAG TAAGGG TGAG GAAGAAAGTC TGGGTCCATG 180

TTTGAGAAGG TGACTGATGG TGGTGGAAGT CCTTCCTGTG ATGAGTTAAT GATG CGTATT 24 0

TCTGATAAAG ATGGGAAGTT ATTTACATCG ACATTAACCA AATCTACCCT TCATGCAGAA 3 00

AGAAAGAGCT CTTGGGCCAT TCTCTATTAA TGAAACCATA CCAGGGTCAA TATTACAGTG 3 60

TCTCTGAAAT ACACTGAAAA TACTTCCCTG GCTCAGGTGG TGGCCCATGC TACCTCCAGG 4 20

CAGTTCTACT TGATTAATGA TGCAATGGAG ATAATCCTAT TGCATCCACC ATCAAGGAGA 4 80

GTTGGGCAGT CAACTCGAG 4 99

(2) INFORMATION FOR SEQ ID NO: 1168:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 425 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 116 8:

GAATTCGGCC TTCATGGCCT ACACAAACAA ACCCAGAATA CTCTATTACT GTATTTGTGG 60

GGTACAATCC ACTCAACTCT ATTATGAAGC CCAAAAAATA AATCTGTTAA AAACAATAAT 120

AG CTACACCA ACCTGTTAAG AGATAGGTAA TATAAAAATA TATAGTTTGA GACAACTAAA 180

TCAAAATGGA GGAGGGGATA GAGTTCAAGA AGTAGAATTT TTTTGCGTGT GCTTTTCTTG 240

GCCTTTGTTT GCTTCTATTC TTTTATTTGG AATCAAAGAT AAGTTATCAA CTCTTTAAAA 3 00

TAACTTGTTA TATGTATAAG ATGTTTTCTG TAAGCCTCAT GGTAACCACA GTACAAAAAC 360

CTATAGTACA ATT CCTAAAA ATAAAATACA AAAAAATTAA AATATACTAC CAGAGAGCTC 42 0

TCGAG 425

(2) INFORMATION FOR SEQ ID NO: 1169:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 318 base pairs

(B) -TYPE : nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 116 9:

480

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GAATTCGGCC TTCATGGCCT AAAAGGTTTG ATCTTGTAAT GTGTCACTGT GTTTCCTTAG 6 0

TGGCCAGCCA GC CTTCAGAA TAGCTAAAGG CCTTCCTTCC TTCCAGTCAG C CTG AG AG AG 12 0

AACACCTGTC CCCTAAGCAC CTGGTGTCTC CATTGGAGGC AGACTGCTCT CAGGAGACTA 180

CTAGAAGCTT CAGCCCGGAA GACAGGCTGC TCTCTCATGC TGGTGGCCCA AATTGAGAAA 24 0

GTGGTGTCCC TTCCTGATTT TGCCACCAGC CCTACCGAAT AG TTGTAAAC CAGTATCAGG 3 00

AATTGGGATC CTCTCGAG 318

(2) INFORMATION FOR SEQ ID NO: 1170:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 346 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1170:

GAATTCGGCC TTCATGGCCT ACATTGGTCG TTTTATTGCC ATGGCACTAT TT CATGG AAA 60

GTTTAT CGAT ACTGGTTTCT CTTTACCATT CTACAAGCGT ATGTTAAGTA AAAAACTTAC 12 0

TATTAAGGAT TTGGAATCTA TTGATACTGA ATTTTATAAC TCCCTTATCT GGATAAGAGA 180

TAACAACATT GAAGAATGTG GCTTAGAAAT GTACTTTTCT GTTGACATGG AGATTTTGGG 24 0

AAAAGTTACT TCACATGACC TGAAGTTGGG AGGTTCCAAT ATTCTGGTGA CTGAGGAGAA 300

CAAAGATGAA TATATTG GTT TAATGACAGA ACGGCGTTCG CTCGAG 34 6

(2) INFORMATION FOR SEQ ID NO: 1171:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1171:

GAATTCGGCC TTCATGGCCT ACACTTTATT CCCTTTTAAG TCTGGTAAAG AATGAATACT 60

TGGACGTTTT GTTTCATGCA GATTTAGTTA GCAACTCGAT TAT CAAATGG TAGAATATCT 120

GTATGCACTG AAGCCAAATT CTCAGTAACT CAGCTTTTGN TAGTCATATG AGGATGATGA 180

ATAATAGGAN T CCAG AGCAG TTAACAAATT GATACAAGTG GTAGGAAAAT TTGATATGAA 240

(2) INFORMATION FOR SEQ ID NO: 1172:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 277 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1172:

GAATTCGGCC TTCATGGCCT AGTTTCNTTT TTGTATCTCT ACTGATATCA CCAGGATAGT 60

NTACTCTCCT TCTAGCTTTC TGCTTACCGC ACACTGGATA ACACACACAT ACACACCCAC 120

AAAAATGCTC ATGAACCCAA TCCGGAGAAG GTTCCAGCAG GTCCCCCACC CTCCCCTCCT 180

CCTCCTACTT CTCCTCTTGA CAGCGAGGAC AGGAGGGGGA CAAGGGGACA CCTGGGCAGA 24 0

481

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CCCGCCGGCT CTCCCCCCAC CCCACCCCCA TCTCGAG 2 77

(2) INFORMATION FOR SEQ ID NO: 1173:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 58 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1173:

GAATTCGGCC TTCATGGCCT AG AAAAGT CT AG AAAATAG C TTAAATAACA AACACGTGTG 60

GATTTGTTAG ACCAAGAGCA AGGGAGACCA TTTAATGCAG TTATTTAACA ATATTTAGTA 120

CTTTCCTTTA CCTTGTCTGC TGTGCCATCA TTCATGCCTG TCAGTGTTAA AAATCCCCAA 180

ATTTCCCAAA CAGATTTTCA TTTCACTTCC GTCAACTTTT AAATTAAAGT TTTTAAATTC 24 0

CTGTCCCCAC TCCTCGAG 258

(2) INFORMATION FOR SEQ ID NO:1174:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1174:

GAAAGTTGCT TTTGATGTCA AAATGGAAAA TGAAAAGTTA GTTTTAGCAT GTGAAGATGT 60

GAGGCATCAG TTAGAAGAAT GTCTTGCTGG TAACAAT CAG CTTTCTCTGG AAAAAAACAC 12 0

TATTGTGGAG ACT CTAAAAA TGGAAAAAGG AGAGATAGAG GCAGAATTGT GTTGGGCTAA 18 0

AAAGAGGCTG TTGGAAGAAG CAAACAAGTA TGAGAAAACC ATTGAAGAAT GTCTTGCTGG 24 0

TAACAATCAG CTTTCTCTGG AAAAAAACAC TATTGTGGAG ACT CTAAAAA TGGAAAAAGG 3 00

AGAGATAGAG GCAGAATTGT GTCGGCCACT CGAG 3 34

(2) INFORMATION FOR SEQ ID NO: 1175:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 03 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1175:

GAATTCGGCC TTCATGGCCT AGTGCTTGAA CTCACGCATC TGTTTTACCT GCATCTG CAG 60

GCGATGGGGC AGGGGCCACG GAAAGAGTCT GAGGGCTGCT TGGTGTAGTC AGGTTGTGTC 12 0

CAGGCATGCG GAGCTGTGAG TGCCTGCAGG AGAGACACCC AGGAGGAGTT TTTACATTTT 180

GGTCTAAAAA GCTCTTGGAT TCATCTCATC TCATGGAATG ATCCTGTCGG ATGACGCTGA 24 0

CGTGATTGCT TCAGACTTAG AGGTGAATAA ATTGAGGTCC AGAGAGGTCA CAGTCACGAA 3 00

GCTCATGGTA GACTGAGGCC ACTAAACACC CGTCTCCTGA TTTTCAGTGG CGTCCTCATT 3 60

TGCATACACC TGGGCCATCT TGGTTTTTGC AAGAAAACTC GAG 4 03

482

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PCT/US98/06956

(2) INFORMATION FOR SEQ ID NO: 1176:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 5 90 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE : cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1176:

GAATTCGGCC TTCATGGCCT AGGTACCTTG AACATGG CTG TAAATTAATC TTTAACTGCC 60

TTGGTGGAGT CTTCCTGATT TATTGAAGAG AATAATCACG AAAATAATTT TTGTTTGTTT 120

TTTGAGACGG AGTCTCGCTC TGTCAACCAG GCTGGAGTGC AGTGCCACGA TCTCGGCTCA 180

CTGCAGCCTC TGCCTCCCAG GTTCAAGTGA TTCTCCTGAT TGAGCCTCCT GAATAGCTGG 240

GATTATAGGT GTGCACTACC ATGACCAGCT AATTTTTGTA TTTTTAGTAG AGATGGTGTT 300

TCACCATGTT GGACCGGGCT GGTCTCGAAC TCCTGACCTC AGGTGATCTG CCCTCCTCAG 3 60

CTTCCCAAAG TGTTGGGATT ACAGG CATGA GCCACCGCAC CTGACATAAA TATTTAATGT 4 20

AATACCGTGT AAGACTTTTC . CATTGGGTTT TGAGAAACAC GTTAATGAGA GAAATTGCTT 4 80

AACATTGGAG AGGATTGCAG AGAATATTGA CTAATATGGT GGGGTGAGGA GGAACAACAT 54 0

CAATTAAGAT TCAGATTTAT TATTTAAAAA AACTAAAAGG CGGCCTCGAG 5 90

(2) INFORMATION FOR SEQ ID NO: 1177:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 562 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1177:

CTCGAGGTAG CCACAGTCCT GATCCTAGTG ACAAATGGGG GCATGTGTCT ACATCCGGGT 60

CGGCGGAGGG CTCATTTCAT CTGGCCTGGG GGGAAATGAG TATTAATTTG TTTACACAGA 120

CGTAAACACA GCCCAAAACG CATCAGCACG TTG ACT CAAA CGCCCGCAAC GCCAGGGCAA 180

AGGCAATTTG GTTAACAGGG GGAAGCGAAC AGACGGAGAC GCCTGGAGAC CCAGGTGCCA 24 0

CAACCCGGTT AATCGCGGTG CAAATAAGGG CAAGTCCCCT CCCCTTGTCC GTGTGGTCTT 3 00

GACAACGACA CTAGTTCATT CTACTAACAA GGCGGGCGGG GGGTCAGATG GGCCACACAC 3 60

ACCCATTTTC CTCAACGGGA CCCCAACGCG ATCTCAGCCT TGCTGTGCTA CTTTAGGGCA 4 20

AGACGCGTTC CCCATTCGGA AG CCGCAGG A AAG CGCGGCG AGAG CGGGTT AGCCCTCGGA 4 80

GCGGCTAAGA GCCTCGGAAT AGCGCAGAGG AAGTCCCCAC CCCTCTCGGG GCTGGGAGCC 54 0

CTAGGCCATG AAGGCCGAAT TC 562

(2) INFORMATION FOR SEQ ID NO: 1178:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1178:

GAATTCGGCC TTCATGGCCT AG AAG CACAG GTAAAACAAG CTGGGGCTTA TGGTCAGCAT 60

483

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TGGAAGCAGG GAG C AGAGTG GGGAAAACAG CAGTCTTATG GGACTGAGTC CTCAATCTGT 120

GTGATCTGAC TCTATCTGCA AGGTAGTGTT GGAAGTGAAC AGGGTTGGAG AATG CCCAGC 180

TGGTGTCCAC CGCAGAATTG ATTTCATGTT TGGTATGCAG GGACCCCCCA CTCCACACTT 2 40

AGTCACAGAA ATCTGTGTTG ATTGTTGTGG CATGAAAGCA GGGAAAAATA GTTTGTTTTT 3 00

TTCTCCACAC TTCCTTCCCA AGATCCCGGC TAACTCGAG 3 39

(2) INFORMATION FOR SEQ ID NO: 1179:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 353 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1179:

GAATTCGGCC TTCATGGCCT ACTCACCGGA GAAAAGAAGT TTCNGAAGAA AACCACAACC 60

ATGCCAATGA ACGAATGCTA TTTCATGGGT CTCCTTTTGT GAATGCAATT ATCCACAAAG 120

GCTTTGATGA AAGGCATGCG TACATAGGTG GTATGTTTGG AGCTGGCATT TATTTTGCTG 18 0

AAAACTCTTC CAAAAGCAAT CAATATGTAT ATGGAATTGG AGGAGGTACT GGGTGTCCAG 24 0

TTCACAAAGA CAGATCTTGT TACATTTGCC ACAGGCAGCT GCTCTTTTGC CGGGTAACCT 3 00

TGGGAAAGTC TTTCCTGCAG TTCAGTGCAA TGAAAATGGC ACATCTCCTC GAG 3 53

(2) INFORMATION FOR SEQ ID NO: 1180:

<i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 296 base pairs
■(B) TYPE: nucleic acid
(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 1180:

GAATTCGGCC AAAGAGGCCT AC AGAGTG CT GTGCTTAAGT TTTACTTCTT TCCACCTTTA 6 0

AATCTCTGAT AAGTTTCTTT TTATCTAAAG GTTCCACTTT GTTCATTACT TTTTGTTTCC 120

TTATTATTGA TTTGTTCGAG AACCTGAGTT TCTTGACCTG TGTGATTTTG TACCACCTGG 180

ACTTTCTGAC TGTGTTTGCC CAGGCTGGAG AGCAGTGGTG GGATCATAGC TTACTGGACT 240

CAAGCCATCC TCCCGCCTCA GCCTCCCAAG TAACTGGGAC TATGGGCACA CTCGAG 2 96

(2) INFORMATION FOR SEQ ID NO: 1181:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 77 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1181:

GAATTCGGCC TTCATGGCCT ACTTGAGTTG TACATTAGAT CTTTAAACTT GTTAGTCCTA 60

CATATCTGCT ATTTTTTATC CTTTGACCTA CATTTTCCCA TTTCCTCCCA GTGTTCTCTC 120

CCCAGGTAAT CATTGTTTTA TTCCCTTTCT CTGTAAATTT GACTTTTTTT TTTGGATTCC 180

ACATATAAGT GAG AT CATG A TCATGCGGTA TTTTTCTTTC TGTGTCTGGC TTATTTCACA 240

484

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TAG TATTATG TCCTCCAAGT CTACCCACGA ACTCGAG 2 77

(2) INFORMATION FOR SEQ ID NO: 1182:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 192 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:llB2:

GAATTCGGCC TTCATGGCCT AG AGATA CTG GCTGGCAATT CTTGGCGTTC CTTGGCTTGT 60

AG CTGTAAGA TGCGCTCTAA TATCAGTCTC TGTTGTCATT TGCCTTTTCT CTGTGTCTGT 12 0

GTTCAAATGT CCTTTTTTTT TTTTTTTTTA GGGAGTCTTG CTCTGTTGCC CACTCAAACT 180

GCTGGGCTCG AG 192

(2) INFORMATION FOR SEQ ID NO: 1183:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 296 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1183:

GAATTCNGCC AAAGAGGCCT AGTAAATAGT TGTTCTGTTA CATTGTTTAG AGAATAATGA 60

CAAGAACAAA AATCTGTGTG TTCAGTATAG ACACAACCAT CCTTTTCTTT TTTTTTTTTT 120

TGAGACAGAG TCTCGCTCTT GTTGCCCAGG CTGGAGTGCA AGGGTGCGAT CTCAGCTCAC 180

CGCAACCTCC GCCTCCCGGG TTCAAGCAAT TCTCCTGCCT CAGCCCCCCG AGTAG CTGGG 24 0

ATCACAGGCA TGTGCCACCA CGCCCGGCTC TTTTTGTATT TTTAGTAGAA CTCGAG 296

(2) INFORMATION FOR SEQ ID NO: 1184:

(i) SEQUENCE CHARACTERISTICS:

(A) ' LENGTH: 2 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1184:

GAAT TCGGAC TACTACAGGT GATACTACAG TGACTACTAC AGTAATTCGG ACTACTACAG 60

GTGG CTAATT CGGATTACTA CAGGTGGACA TAATTCGGAC TACTACAGGT AATTCGGACT 120

ACTACAGGTG AGCTAATTCG GACTACTACA GGTGGACATA ATTCGGACTA CTACAGGTGC 180

ACCTGTAGTG GAGAACATTT AG CAATG ATA AAGCCGCTGC TGATCCTTCT CGAG 234

(2) INFORMATION FOR SEQ ID NO: 1185:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 300 base pairs

(B) TYPE : nucleic acid

485

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(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi ) SEQUENCE DESCRIPTION: SEQ ID NO:1185:

GAATTCGGCC AAAGAGGCCT AGAACAGTTT AGAAACAATT TCCCTGCCTT TGCTTTGGGT 60

TCCCTGTGAT TGTTCTCCAC ACTGTTTTCC TGGCTCTATC TGTCTCCCTT GCCACGGCCA 120

CTCAAGCCTA GCTGCCCAAC AGCTCCTTCC CTGAAGAACC CCGGCCTTCA GGCTTGACAG 180

GTGATCTCAT CCCTCTTCTT TTCCTCCAGG TTGTTGTAGA CTTCCACCTT CCCTTCTTCT 24 0

CCTGGTCCTT TCCCCTTTCT AGTG CCAATG TGGGCCACGC TTTCATCCCA CCTACTCGAG 3 00

(2) INFORMATION FOR SEQ ID NO: 1186:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 324 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 118 6:

GAATTCGGCC TTCATGGCCT AGTGATGAGC CCTCCTCTTC AGCTAGGAAA ATGACGGTGT 6 0

TCAGAAAGTT AAAACTTCTT CGCTGGAAGG ATTTCATCTT AAAGTTGGGA GACTGGAAGA 120

AATTAAAGTG TTCTAAATGG AAGAGCATTC ACCACATGTG TTCTGTTTTG GGTTGACATT 180

TAGCTTTTGT TTTTATTTTA GAAACGGAAG ACTCTGGTAG CAGTCCTTGA AATCTTGATG 240

CCATTGCTAT TTTCTGCATT GTATTGTATC TTCGTTTTAG TAGTGCTCCA ATAAAAAGAC 300

CTGCTACTAG CTGCAAAACT CGAG 324

(2) INFORMATION FOR SEQ ID NO: 1187:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 08 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 118 7:

GAATTCGGCC TTCATGGCCT AGTACGTTGC TGAAAAGAAG TTTATTGCTA TTTTCTTATT 60

TTATTATACA AAACTAGATT TGCTTAAAAC ATTTCCCAGT CTCTTTAAAG GAATGCTAGT 12 0

TAGTGGGAGG CCACAGCTAG TAAATTACCC TCAGTAGTGG TTTCAAGTAG TCCATAACTA 18 0

TAAAAATCGT TACGGCCAGG ATATG CCGG A ACAGAACACT CCCCACTGGG GTCCTCAGCC 24 0

TTGGATGTCA GCTCGGCCCC TCAAGGGGTC CCTACACCTG GAAGCTGATT CCACTCATCA 3 00

GTCTCGAG 308

(2) INFORMATION FOR SEQ ID NO: 1188:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 251 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

486

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PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1188:

GAATTCGGCC TTCATGGCCT AGAATGAAGA AGGTTCCCAA GAAGTTAGAG GAGATTCCCC 60

CAGCCTCTCC GGAGATGGCA CAGATGAGGA AGCAGTGCCT GGACTATCAT TACCAGGAGA 120

TGCAGGCTCT GAAGGAGGTC TTCAAGGAGT ATTTGATTGA ACTGTTTTTC TTGCAACACT 180

TTCAAGGGAA CATGATGGAT TTCTTAGCTT TCAAGAAGAA ACATTATGCC CCATTACAAG 24 0

CACCACTCGA G 251

(2) INFORMATION FOR SEQ ID NO: 118 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 3 59 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 118 9:

GAATTCGGCC TTCATGGCCT AAGGAGTTGG AAATTGTGCA CAAAGAAAGG TGGTGAATAA 60

GTAAAGTCGT AAATTCAAGA CCACAACAGA AAGCTTCACT G CAGACACTG GACTTGAACC 120

ACCATTGAAA ACAGT CAGGA TTTGGAGATG ATAATTAGGA GGATGTGTAT TCTAGCTGTG 180

GAATTTATTG TGGGCAAGCA TAGGAATGAG AAAGTACAAT GAAAAAATGT AAGTAGACCC 240

ACCAAGTTAG AGAAGAAGGT CCTGGTTAAG AAAAATGAAA GATTTTTTTG AACAACAGAT 3 00

TAATGTGATG AAATAGATGT TCAAGAGTGA AGATAAGTTG AAGATAGGGA CCCCTCGAG 3 59

(2) INFORMATION FOR SEQ ID NO: 1190:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 1190:

GTTGTTAGGC TGGTGTTGTT ATGTTGCTGT TGTTATGCTG GTCGTGCTGC TCCATGTTCT 60

CCAGGTGTTC TTCCCTTTTA TCGTCACAGT TACCCCGTAC ACCTGACAAC TGGACATCTG 120

CGCCTGGGGT CTTCAGCCTA AACACACCTA AACCCTCCAC CAAACCCCTC TGCTTCCGCC 180

TCCCCGTGTC TGTGAGCGCC TCCACTGCCC ATCCCTCTGC TCAGGCCCCA TTTCCAGGGC 240

TCGAG 245

(2) INFORMATION FOR SEQ ID NO: 1191:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 257 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO:1191:

487

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GAATTCGGCC TTCATGGCCT AGTCTCAAAA AAAAAAAAAA AAAATAGTGT TCAGCAAGGT 60

TGAAGCATAA AAGG TTAAT A GCCAGAATCA TTTATCAATT G T ATTTCT AT ACATCTACAA 12 0

GACACAATCT GAAAATGAAA TTAGAGAAAC AATTTCACTG GGCAACAAGA GCAAAACTTC 180

ATCTCAAAAT AATCATCATC AT CAT CATCA TCATCATCAT CATCATCTAC AATGTCATTT 24 0

CCCATCCAAC GCTCGAG 2 57

(2) INFORMATION FOR SEQ ID NO: 1192:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 74 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1192:

GAATTCGGCC TTCATGGCCT AAGGACATGG CAGAGTTCCT GCTAAAAGAG AAGACAGTTA 60

TTTAAGGAGG TTTGAG ATT C AAGGGCTTTT TTAATTTTAA AATTAACCAT GGTAGAAACC 120

TGTGTGTTAA TATGCTGAGG GAAGTTGCCA ATAGTGAGAT GAAAGATCTA GGCAAGGGGA 180

TAGCAAGGTG ACTGCACCAG ATACCTGGAT CTGGGCAGGA ATAAACCTCA ACAGTGATCA 24 0

TGTTGACCTT GAGTGACAGG GTATAATGTT TGGGAAGGTG CTTTGTAAAC TAT AAGGGG C 3 00

AATACAAACA TGTAGTACAC CTTCTCTGAG ATCCGGGAAA GGACAACCTG AGCATAGGTT 360

GGGGCTGGTC ATAGGC CACT CTCCCCTACT GTTTCTCTAG AGTGTGTGTA GTCCCTAGCA 420

AGTCTCAGAT GCCTCGACCT TCATGGCCTA GAG AGTTCT C ATCAGAACAG GAAGGCAGTG 4 80

ATGATCCATT GCATGGGCAG GATTGTT CTA CGAAGACGAA GATCTCCGGA AAGTGAAGAA 54 0

GACCCGGAGG AAACTAACCT CAACCTCTGC CATCACAAGG CAACCTAACA TCAAACAGAA 600

GTTTGTGGCC CTCCTGAAGC GGTTTAAAGT TTCAGATGAG GTGGGCTTTG GGCTGGAGCA 660

TGTGTCCCGC GAGCAGATCC GGGAAGTGGA AGAGGACTTG GATGAATTGT ATGACAGTCT 720

GGAGATGTAC AACCCCAGTC GACTCGAG 74 8

(2) INFORMATION FOR SEQ ID NO: 1193:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 227 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1193:

GAATTGCGAA CATGGCAGCG CGTTGGCGGT TTTGGTGTGT CTCTGTGACC ATGGTGGTGG 6 0

CGCTGCTCAT CGTTTGCGAC GTTCCCTCAG CCTCTGCCCA AAGAAAGAAG GAGATGGTGT 120

TATCTGAAAA GGTTAGTCAG CTGATGGAAT GGACTAACAA AAGACCTGTA ATAAGAATGA 180

ATGGAGACAA GTTCCGTCGC CTTGTGAAAG CCCCACCTAA TCTCGAG 227

(2) INFORMATION FOR SEQ ID NO: 1194:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 258 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1194:

488

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GAATTCGGCC TTCATGGCCT AGTATATATA TAAAATACTG AGGATTTAGG GCTGATGTAT 6 0

ATAAATAAAA TACTGATAAC TTTTTTCCTT TCTTTTTCTT TTTTTTTTGA GATAGTGTCA 120

TGCTCTGTTG CCCAGGCTGG AG TACAGTGG CACCAAACCG CTAACTGCAG CCTTGCCCTC 180

CCAGGCTCAA GCAATCCTCC TGCCTCAGCA CCCTCAATAA CTGGGACCAC AATTGCATGC 24 0

CACCAAACGC ACCTCGAG 258

(2) INFORMATION FOR SEQ ID NO: 1195:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 314 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

Cii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1195:

GAATTCGGCC TTCATGGCCT AATGAATTCT CATTTCCTGG AGGCTGAAGA TCTGTGCAGG 6 0

TGTCTGTGGC CAATGTTAAG CCTACGACTT TAGATGAGCT GGCATAAATC TTGGGAGAGT 120

TTTCTTGTCT GTGTTCCCTC TGAATTTCTC TGTGCTGTTA GAGGCAGGGA CAGAAGAGAA 18 0

CCAGCATGGC AGTGCTGGGC TCAGGGTGAT GCCTGCCTGC CAGCACAGCG GTTCTTGTCC 24 0

CTGTCCCACA TTGCTTCTTG GAAGCCTTTT TACAGCCTCA ATCATCTTGC TTTTTCTACC 300

GCAGCTATCT CGAG 314

(2) INFORMATION FOR SEQ ID NO: 1196:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 85 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1196 :

GAATTCGGCC TTCATG CGGG GACTTCCACT CTTTCTCGTT TTCTCGGAGC TCCGCCTCCA 6 0

GCTCCTCTAT CTTCCTCTTC AGCTGCGTGT TCTTCTCCTC TCTGTGGATC TCACGGCCTC 120

TTCCTCTGCT CCACGCTGGC CACCGACTCC TGCAGCGCCG TGGGCAGCCG GGCGTCGCTC 180

TCCCGCCGGG TCTGCAGCTC CATCTCCCAC CTCTTCCCGT GGGCAGCTCT CTGCGTCGAG 24 0

GCCGCCTTCA GCTTGTGGTT CCCAGACTGC AGGTGCGTGT CAGCTGCAGC GGCCTGAGAG 3 00

GCCTTTCATC GTCCGTCCCG TTGACACTGG ATGCCGGAGT AGAAGATGGG GCTCCATGCC 3 60

CGGATTCTCG GGATTATTAC TCGAG 3 85

(2) INFORMATION FOR SEQ ID NO: 1197:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 256 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE : CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1197:

GAATTTGCAG TG AAC CGAG A TTGTGCCATT GCACTCCAGC CTGGGCAAAA GAGCAAGACT 60

489

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CCATTTCAAA AAAAAATCTT AAAAATACGA AGTTTTTCAT TTTTCTTAAA TTTTCATTGT 12 0

GACTACTTTA GTAGACTTGC CAGTAATAAG CCAGTTACCG CTTGAATCTC AGTTTCTTTA 180

TCTGGAAAGT GGTCATTATT TATCTGCTGT CCCCTTACCT AGAGGGAATC AAATGCGTTT 240

GATACAGGTT CTCGAG 2 56

(2) INFORMATION FOR SEQ ID NO: 1198:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 44 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1198:

GAATTCGGCC TTCATGGCCT AG AGAGC CCA TCTCCATCTG CCAG CCTGGA AGCAGCCATG 60

GCAAATGGGA TGTGTCCCAC TGCCCCCGTT TGGTGCCACA GTTGGGTTTA TTCTCACAGC 120

TGCAAACCCA CGTGCTGGGC TGCACAGCTG CCTGAACGAA GCTGGAGCGT GCAGAACAAA 180

CTGCATGGAA TGTCACGTGG GGTTTTCCAC TCTCGCCCAC AGTGAGTTGG CAATGCCTGG 24 0

CCACGTGTGC TCTGTGGTCT TTGAACTTGA TCTGGGAGGA CAGAANTTCA AAAGGAAGAT 3 00

GAAGGCCCCA G CAAGGG AGG TATTCCTGTC TTGAGCAGAA GGTAAAGGTA GAAGGTGCAG 3 60

ATTAGGTACT GGGAATAGTC ATGGTTTGGT TTGAATGGAG TAGAAGATTC CAGAGGAAGA 420

GCAGTGGGGC ACAGTGGCTC CTCGAG 446

(2) INFORMATION FOR SEQ ID NO: 1199:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 36 9 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1199:

GAATTCGCCT TCATGGCCTA AATTGTAGCT AGGAAAATAA TATATGTCTT AGTTTAAGAA 6 0

CTCATACTCT GGAATCAACT CATTGCACTT TCCTATATGT TTGGCCATGG GCAAAGCACA 12 0

TAACCTCTTA ATCAATTGG C TCG T CTCCAA G GTGAGG ATA GTTATACTTA ATCCTCTTTA 180

GGAGTGAGAA TAAAAATTAA ATATGTGTGT AG CATAGTG T CTACAATGTT AGAGGTATTT 240

GAAAAGTGAT AGTTTATTTT TTGGAATTAT TTAGCATTAT TAAAAACAAG GGGGAG CACA 3 00

CGGTGGCACG TTTCTGGTCC CAGCTACTTG GGAAGCTGAG GTAGTAGGAT CGCTTGAGAT 3 60

CCG CTCGAG 369

(2) INFORMATION FOR SEQ ID NO: 1200:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 83 base pairs

{B ) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1200:

GAATTCGGCC TTCATGGCCT AGACAGGTTG CTAGCTACAT GGGTCTCTGA AGAAGAGTTT 6 0

490

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TCCAGCAGAA GGAGCAACTA GTGCAAAGCC CCTGAGACAC AACTGCACCT ATCCAGATTA 120

AGGACCACGG AGGAAGCCAC TGTAGGAGCA CAAAAAAAGT AGGAGATGAA CAGAGAGGTG 180

AGGGAGGCTC CGTAGGTCCT AGTATGCACT TTGGCATTTA TTTACTGATT GAGATGGCAG 24 0

GTCATTGGAG GATTCGGAGC AGAGGAAGGA TATAATCTGA CATTTTAGCA GGATCCCTTT 3 00

GAGTAAGTTA GCTGCGTAGA CCTAAGATGA ACAAGGACAG CCACAGCAAG ACCTGTAAGG 3 60

AGACTATCCT TGTAATCCAG GCAAGAGATG ATGGCAGCTT GGACCAGGGT AG TAG CAGTG 4 20

GAATTGATGA GAAGTGGTTG AAATCTGGAT ATATTTTGAA GATGGAGCCC ATGGGGTCTC 4 80

GAG 4 83

(2) INFORMATION FOR SEQ ID NO: 1201:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 192 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 01:

AC CATAT AAT TTGCCACTTG AAGTGTACAA ATTCAGTGAC TTTTAGTAAA TTCACAGTTA 60

TATATTCATT AGGATATTCA GAGTTATATA TTCAT CACCA CAGTCACTCT TAGAACATTT 120

TAATAACCTC AAAAAGAAAC CATGCACTCC TTAGCCATCA CTCCTAACCC AACTCTCCCT 180

CTACCGCTCG AG 192

(2) INFORMATION FOR SEQ ID NO: 12 02:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 281 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1202:

GAATTCGGCC TTCATGGCCT ACTTTAAACA TGTGGTCTTA CTGCCTGCAA ACACATACAG 6 0

ACTCTTAATT TTTATTTACA TAGATGTAAA TATACACATA TATTACTCTA AAGATAAACC 12 0

TTAAGGGTAA GAAAATTATA AAGTATGTGT GTTTNTGTGA ATATGAATTT GTACCTATAT 180

TCAGAAGAAA AGAGCAATAT TGGCACAAAA CAAATCATCT TAATAAGGTA ACTAATTGGN 240

TGNGTGCAGT GGCTCACGCC TGTAATCGCA TCACACTCGA G 281

(2) INFORMATION FOR SEQ ID NO:1203:

(i) .SEQUENCE CHARACTERISTICS:

(A) LENGTH: 328 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1203:

GAATTCGGCC TTCATGGCCT AGTGATCTAC TTAGGTAGCT CCTGGAAAGC AAAGGAGAGA 60
GAG CAAG AC C TGTACAGACT TTGTTTATGA GGAAAGCTAT ATAAGGATTA TAAGAACTGA 120
TAAATATTTC TTTGTTTCCT TTTTGACAAA ATGGATTTTC TTCAGTTTCT TAAGCAGATG 18 0

491

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TATTATTTCT GGGACGTTTT AGCCATGTAG TTTCTTTTTA TTCCTCTTTG ATACCCTGAA 24 0

TAACTAGCCT TAGAAACACA AGTAAAGCTC CCAAAATTTC ATTTTCTACA TATTTTATTA 3 00

CCAGATTGAA TTCTAGACCT GCCTCGAG 328

(2) INFORMATION FOR SEQ ID NO: 1204:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 07 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 04:

GAATTCGGCC TTCATGGCNT AGGTCCTAAA AAGAGTAAAA GGTG AAAAC A CTAAGTGATA 60

TTCNAAACAA AAGAAAAAGA TGAAAAATAA GAACCTTGGT TAAAGAGCAG T CGAAATAAG 120

TAATGATTAT AGCTATGATT TATATAGCAC TTNTTACAAG AAGCCAGGCG CTGTTTTAAA 18 0

CACTTGACAT ACTTATTTGC TCATTTCATA ATTGTAACAA CCCTATCAGA TAGGTACTAT 240

TTTTATCCCA CTTTACAGAG GAGAAACTGA GGCACAGAAT TTTAAGTGAT TTGGCCGGGT 300

GCTCGAG 3 07

(2) INFORMATION FOR SEQ ID NO: 1205:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 425 base pairs

<B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 05:

GAATTCGGCC TTCATGGCCT AAAAAAAAAT GTAGTCTAGA AAGAGACTAG GAATAGAACA 6 0

CTGCTGACTT GTTCTTATAC CAAGAGCTGG AGG CATAAAC AG TTTTAAT A AAAAAGAATA 12 0

CTTTGTATCT TTTGATGTAA CTTCCCTTTA GAGATT CTG T TTCCCCTGTC TTAAATTG T C 180

AGGCTATTTC TGATTGCTGT TTAAATAATT GGTAGTTACT AT TTGAGT CA NGCTTCTTAA 24 0

AAAAAAAAAG ATATAAAAAT TCGCCAGCTC AGCTTTCATT TAATTAGTAT CAAAGAAATG 3 00

ATATCTGTGG CAGTGAACAT TAGTAGCTTG TTCCAGGGTT TATTGTAGGT TTGTTCAAGT 360

CAGTACTGCC CATCTTGGCA CTTAGGTTCT TGGAATACAG AGGTGGATAA GGTTTGCCCC 420

TCGAG 425

(2) INFORMATION FOR SEQ ID NO : 1206 ;

(i ) • SEQUENCE CHARACTERISTICS:

(A) LENGTH: 504 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1206:

GAATTCGGCC TTCATGGCCT AAGACCAGCA CCATCGTGAG CAAGATTCCT GCTGCGCTGC 60
TTCCAAAATG GAAAAGCATC ACAACTAAAT ACCTAATATC CTACCAAACA AACCACAGTC 120
CCTACGTAGC CCTACTTCAG TCCCAGGAGA AGGAATCCAT GAATGGGCTG AGGTT CCG AG 180

492

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GGTAGGTTGT GGATGTCTTT CTCTAGAGGG GTCCCACACC TGGAAAAGAG GACACCCAGC 2 40

CCGNGGGATG AGGGAAGCTG GGCAAGGGAG AAAGTTGTTG AGTCACACTG GGGACCCCAG 3 00

ATGTAGTGAG CTCAG CAAGA AAAGCCAGGT C CAG AG AG AG TCGCACAGAA TTCCTGACTC 3 60

ACAGCGCCCC TCGGTCCACA GTGGAGAGGA GGAGGAGGAG GAG C AG AAGG AGGGGGAGGA 420

GCTGCAGGAG GAGGAGGATT TGAAAGCGCT TTGGCCTTGT GTTATGTTTT GCTTCTTTTC 4 80

TGTGCCCCCC TCTAGGCCAT GAAG 504

(2) INFORMATION FOR SEQ ID NO ; 1207:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 242 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS s double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1207:

GAAATTTTTC AGTAACTCAG TGTCTTTAAC TAATAATTTA ATCATTCTAG TAAGAAAACA 60

TGCTTTGTAT GATTTTAGTC TTTACATTTA TTAATTTATG TAAATTAATA TGTGGGTTTT 120

ATGATCACCC ACGACATTGT CCTAACTTGT CGACTGTTCT GTGTGCTCTT TTAAAGAAGG 180

TAGTCTGTTG GCCGGGTGCG GTGGCTTACG CCTATAATCC CAGCACTTCG GACAGGCTCG 24 0

AG 242

(2) INFORMATION FOR SEQ ID NO: 120 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 152 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1208:

GTAGAATTGT ACAGTGCTTA TGAGTTATGC ATGTGTTCCT GGTCTTTGTT CTAGGATTTT 60
TTTTTTTTTT TGATTGCTGC TCCAGTTGCC TTACTTACTT TGACATTGGA GTTGACCACA 120
TGATGGTGTT CCACACTTCC CCTAGGCTCG AG 152

(2) INFORMATION FOR SEQ .ID NO: 1209:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 317 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1209:

GAATTCGGCC TTCATGGCCT ACTACCCCTT TATCATTCAC TAACGTGAAT GTGGTGCTAA 6 0

TTTTTCCAGT CCATATCTTT GAACTTTTTG TAATATATGC ACATCAATAA GCAATCGAGT 120

TTTATCTATT CTAATTGTTT TAATGTACAA CTTTATGGGT ACATGTGCAA TTTTGTTTCT 180

TGCATGGTGG CCAAATCAGG GCTTTTAGAA CAT CCAACAT GCGAATAATG TACATTGTAC 24 0

CCATTAACTA ATTTCTCAAT ACTTCTGAGT CTTCCTTGTC TATGATTCCA CTCTCTACAT 3 00

CACATGTACA CCTCGAG 317

493

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(2) INFORMATION FOR SEQ ID NO:l2lO:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 2 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 10:

GACAGATTTC ATTACCTTGA AGTTCACTGC ACTGAACAAT TCTCACTCTG GATGTATTCC 6 0

TGCTCTAGGA TGTGAATTTA GACTTTTGTA ATAGAGTGGG CTTTGAGAAA TAGCTTTTCT 12 0

GCTCATTTTA GTTTCATGAT GACTGCATGG AATGTTTTGC TTCACGCTTA TGCATTGAGT 180

TTTATCAAGC ATTAAGCAGT TGGCCGAAAC AGGTAATACT TGAACATTCA G T CCAAG AAA 24 0

AACAAAATGG ATTTGAACAT ACGTAGAATC AGTAAACTCG AG 282

(2) INFORMATION FOR SEQ ID NO: 1211:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 82 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1211:

GAATTCGGCC TTCATGGCCT AGTCAAACCC TAGAGCAATG CAGGCCTTGT TACAGATTCA 6 0

GCAGGGTTTA CAGACATTAG CAACGGAAGC CCCGGGCCTC ATCCCAGGGT TTACTCCTGG 120

CTTGGGGGCA TTAGGAAGCA CTGGAGGCTC TTCGGGAACT AATGGAT CTA ACGCCACACC 180

TAGTGAAAAC ACAAGTCCCA CAGCAGGAAC CACTGAACCT GGACATCAGC AGTTTATTCA 24 0

GCAGATGCTT CAGGCTCTTG CTGGAGTAAA TCCTCAGCTA CAGAATCCAG AAGTCAGATT 3 00

TCAGCAACAA CTGGAACAAC TCAGTGCAAT GGGATTTTTG AACCGTGAAG CAAACTTGCA 360

AGCTCTAATA GCAACAGGAG GTGATAT CAA TGCAGCTATT GAAAGGTTAC TGGGCTCCCA 420

GCCATCATAG CAGCATTTCT GTATCTTGAA AAAATGTAAT TTATTTTTGA TAACGGCTCG 480

AG 4 82

(2) .INFORMATION FOR SEQ ID NO: 1212:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

*'

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1212:

GAATTCGGCC TTCATGGCCT AGGGTGATAT TTAACTCGTT GCCAATGGCT AAG CTCCAGA 6 0

CTTTGCCTCT CACACTTGGA GGGATTCCCT GCCACCATAA ATCTCGAACT TT TCTAGAG C 120

ACCACATTGT TTCCCAGTTA GGTAAGATCT CATTATTCCA GGTGAGCACA GCGTTTCCAA 18 0

TGCTTTCCTC GACTCTGCAT CTTTCTTCCA GCTGCTTCTT CCTTCGCTGG GCTTCTTTCA 240

GCTCTCGCTT TTTGGCCTGA ACCACCATTT CTTCATACTG CTGTCTGTGC TTCTGAGCTT 300

CTTCAGCTGG TTTTGCTGGG AGATTTGCTG GTCTGTCCTC GAG 343

494

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(2) INFORMATION FOR SEQ ID NO: 1213:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1213:

GAATTCGGCC TTCATGGCCT AGAGAAACTA AAACTCAGAG AAGTTAATTA CTGAACTCAA 60

GATCCCAAAG TGCTGGGATT GCAGGCGTGA GCCACCGCGC CTGGCTGAAA GAGCTTTTTT 120

AATGTATTAT TTATTTGTGT CAGGATAGAC TCATTGATGC GTGTTTTATT CAGTGGGTTA 180

TAATTCTTTA TTATGTATTC TGATGTTGGT GTTTTCCCAG TTTTAGC CAA TGGCATCCCC 24 0

TTCCATCTGG ATCCTGTGTT CTTTTGACAT GGCTCCAATC TCGAG 285

(2) INFORMATION FOR SEQ ID NO: 1214:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1214:

GAATTCGGCC TTCATGGCCT AG AACCAGG C CTTCCAGTAC GAGTTTGGAG CCATGTATGC 60

ATGGATGCTG TGTGTCTTCA CTGTCATCGT GGCCTACAGC ATCACTTGTC CCATCATCGC 120

GCCATTTGGC CTCATCTACA TCCTGCTCAA GCACATGGTG GACCGGCACA ACCTCTACTT 180

CGTCTACCTC CCAGCCAAGC TGGAGAAGGG GATCCACTTT GCCGCTGTGA ACCAGGCCTT 240

GGCAGCCCCC ATCCTGTGCC TCTTCTGGCT CTACTTCTTT TCCTTCCTGC GCCTGGGTAT 3 00

GAAGGCCCCC GTCACTCGAG 320

(2) INFORMATION FOR SEQ ID NO: 1215:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 44 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1215:

GAATTCGGCC TTCATTTTGA AAGATATTTT TGTAAAAATC TGTTTGTTTT CTTTTAATAC 60

TTTCCAGTGT TATCTGGGTT TCTTAATTTC TGACTTAAGG TCTGTAATAA TTTCTGCTTT 120

CATTCCTCTT AATATATTGT GTCTTTCTTT GTCTACATTT AAGATTTTAT CTTTATCACG 180

TGTTTTGAAA AGTTTTATTT TGATGTGCTC TTTATGTTTT TCTTTATTTG TAGTGCTTGG 24 0

ACCTTGTGGT GCTTTTCTTA TTTATAATTT TCATCAAATT TGGGGGGTTT GACCATTATT 300

GCTTCAAAAA TAATCTCTGT TCTCTTTCTT CACTTTCTCC AGTTACATAC TGTAGAGTAA 360

ATGATAGCTA CCGAAGACAG AGTGATCCGT GATAAATATC ATTAATGCCT CTGAAGAGGA 420

GAATGACTCC AGTGGAAC CA CTCGAG 446

(2) INFORMATION FOR SEQ ID NO: 1216:

495

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(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 263 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1216:

GGACTTTTTG GAGAAGCAGT ACTATTCATT AATTAAGTAT AGAGTGTCTT GTTAATCCTA 60

AAAGAAAGAG AGCCTTAATG AGGATCATGA ATTTTTTTTT TT XTTTTTTT TTTTGGGATG 12 0

GAGTTTCGCT CTTGTCGCCT AGGCTGGAGT GGGGTGCTAT CTCTGCTCAC CACAACCTCA 18 0

GCTTCCTGGG TTCAAG CGAT TCTCCTGCCT CTGTCTCCCG AGTAGCTGGG ATTACAGACA 24 0

TACGCCGCCA TGCCCAACTC GAG 263

(2) INFORMATION FOR SEQ ID NO: 1217:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 325 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1217:

GAATTCGGCC TTCATGGCCT AAACAACAAC AATAACAACA ACAAAAACAT GTATAACTGG 60

GAAAAAACTG AAAGAGAATG CAGGATCATA AAAATATAGC AAACAAAGTG AGTGGGATTT 120

AAAATTAGTG GAATAAGAAA TAATGGGTAA CAATGAAGAA CATAATTTAG GTAATAGTAT 180

AGTATCTTGG GAGCCCTCCT GGAAGTATCT AGTTATGGAC AGTGAGCAGC AGAAACAGGA 24 0

TGTAACTCAA TTCAGCATAC TTGATGGTTG TGGTAACCCT AGAAAATGAC TCCAGGAAAT 3 00

AGGTGAGAAT CCAATCTATC TCGAG 325

(2) INFORMATION FOR SEQ ID NO: 1218:

Ci) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 293 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:12l8-:

GAATTCGGCC TTCATGGCCT ACAGAGATAG GGTCCCATCC AGGTTCCTAA CTGGGTGGCA 6 0

CATGCATGGG CTAGATCCAA ATAG CAT TGC AAAGGCCTGG AAAACAGAAC TAGAATTGAA 12 0

ACCACCGCGG AAGACTCATT CGAACTCGTG GGCTGAACTC AACCAGGTCA ATGCTTCAGA 180

AAAATACCAG CATTCTCCAC AGGACATAAA CAAGATTGTC TCATAACATA CCATTCAAAA 24 0

TATTAGGATA CAATCCAAAA TTGCTCATCA TAAGAAGACA GGAAAAACTC GAG 293

(2) INFORMATION FOR SEQ ID NO: 1219:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 265 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

496

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(D> TOPOLOGY: linear
(Xi) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 1219:

GAATTCGGCC TTCATGGCCT ACGAGGATTG GGGTAGGTAT GNGCTTTNGG CTCATGTTTG 60

TGATGATAAC TGAAGTCTNT TGTGGGTCCG ACCTGTTGTA GGGTGTGGGG GAAAGTGAAG 120

GAAGAGAATG AAGGTGAGTC CCCGCCGTTG CAAACCTTCA CCAAACCACG CGGCCCAGTT 180

TTCGTGAGTA CCCCTGTGTC CCAGAGAGGA GGACCCAGCG TCCTCGGCTC TGCCGCAGGC 240

CTTCTTGGTC TGGTGGGTAC TCGAG 265

(2) INFORMATION FOR SEQ ID NO: 1220:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 S base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) topology: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1220:

GAATTCGGCC TTCATGGCCT AAGGAATTGA AACCCAGTAC TTTGCAGAAC TTCTTATGAC 60

TTCTGGAGTG GTCCTCTGTG AAGGGGTCAA ATGGTTGTCA TTTCATAGCG GTTACGACTT 12 0

TGGCTACTTA ATCAAAATCC TAACCAACTC TAACTTGCCT GAAGAAGAAC TTGACTTCTT 180

TGAGATCCTT CGATTGTTTT TTCCTGTCAT TTATGATGTG AAGTACCTCA TGAAGAGCTG 240

CAAAAATCTC AAAGGGGGAT CTCGAG 266

<2) INFORMATION FOR SEQ ID NO: 1221:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 312 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1221:

GAATTCGGCC TTCATGGCCT AGCTCATTCT GCTGGGGGTA GAGATGAGGG GAGGGAGTAA 6 0

GTTAAACCTT GGACTAGCAA GTAGAAGCCT GGGGGGATGC GTGTGCCTCA GTTTCCTCCT 120

CCACAACTGA ATATAGTGGC TGAAAACTGG GGAGATACTT GATGGCGCGA ATGTCCGTTT 180

TCTCTCCCTT CCCACCTCCT GCAGGAAGCA GGACGGGGCA GGCAGCACCT GGTAGGCACA 24 0

GTGCTTTGCC CCTCCTCCCC TTCCCTTCTG GAAGTCTTGG GGCCTCAGTG CTTGCAACAG 3 00

CCACTCCTCG AG 312

(2) INFORMATION FOR SEQ ID NO:l222:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 512 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

497

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txi) SEQUENCE DESCRIPTION: SEQ ID NO: 1222:

GCGATTGAAT TCTAGACCTG CTGGCCTCAA GTGAACCTCC CGCCTCGGCC TCCCAACGTG 6 0

CTGGTATTAC GGGCATGAGT CATTGTGCCC AGTCACAGAA TTCATTTTAT TTGTGAAAAT 120

ACAGTGGTAC AAGTAGGCCT TTGTTAAATG ACTAACCTGA AACCTCTTGT GAATGACAAA 180

CTCCTCTCTA CTCCAAATAC TGGCCCATCC CTGCTTAAAT ACTGCTCAAT GAAGTTACTC 24 0

ATGCTAGTTC TTGAGGGAGT AACTCTAGAA TGATTCCATC TAGGAAGACA TAAGATAAAA 300

TGGTAAGTAT TCTAAGTTCT ATAGGTAGTT TAGTCATGCC ATATTATAAA CCTCCACTCC 360

AAAAATAGTG TGAGGTCATT TCTGGCCAGA GTGAAATAAA AAATGTATAA TGCCTGAACA 420

GTCTATTATT CTGACAATGA AAAAGATTAA TGCAGTTCCC TTTATCACTT GCATGAGTAA 480

AAAAATATAT ATATATATTG GCTGGGCTCG AG 512

(2) INFORMATION FOR SEQ ID NO: 1223:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 447 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1223:

GGGTGTTTCA TACAAAGAAT ACAAGTAACT GATGAATGAA GGGGGCATCT TGTGTCCCCA 6 0

CAATCCTGCT GTGCGCACAC CACAGGTGAG CCGTTCTGCC TAAGGGAACA GCCCCGGCCC 12 0

CTCCCTCCGG CTCCTCCCCA GCACCGTCTC CTCCACCCAG TGGCCTGGCC GTGGATGCTG 180

CCTGTGGCCC AG CTT TGAGA CACCGCCCTG ACACGTGTCC AGCCTTACGT GGAAGGATTT 24 0

GTCTGTTTTG TGGCATCCTA GTAGATG CCA CGTTAGTAGA TGC CATGTTA GTAGAAGGGA 3 00

TGTGGGCATT TCTTTGTAAG TTCCCAAAAG CCTATGAGGG TTTTTTCCAC GATTCCGTTC 3 60

CCAGTTTGGC TTTTGTTGTT GTTGTGGCTG TTCTTGGCCC CCCTGGGCCC TGCAGTGGAG 420

TGGGGGGCTG CACCTGGGAG CCTCGAG 447

(2) INFORMATION FOR SEQ ID NO: 1224:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 235 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1224:

GAATTCGGCC TTCATGGCCT ACTTTGTTTT ATATAATAAA GTATGCCTGT TATATTAAAT 6 0

AATAAGAATA TGGCAATTAG CGATATAGCA TACCCAAACA AAGATGTTCT CGATACAGTC 12 0

TGGCAAAGAC TATCCCAAGG TTATTTTAAT GAATTCAGAC ATTTTTTCCT GTGGATATTT 180

CTCCATCCTA AAAAAAGTGG GAACCAAGGA AAATATTTAG ATGCAAATAC TCGAG 23 5

(2) INFORMATION FOR SEQ ID NO: 1225:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 134 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

498

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 122 5:

GCGATTGAAT TCTAGACCTG CCTCGAGACT GACGCCGCAC CATGACCCTC CTGCTGCTGC 6 0

CCCTTCTGCT GGCCTCTCTG CTCGCGTCCT GCTCCTGTAA CAAAGCCAAC AAGCACAAGC 120
CACCGCATCT CGAG 134

(2) INFORMATION FOR SEQ ID NO; 1226:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 556 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: doable

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO. 1226:

GAATTCGGCC TTCATGGCCT ACACACATCT GGTAAG GAGA AGCACGGAAG GCCTTTGTTT 6 0

CAGACAATCT TTTAAATGAT GTTTGTATAG GGAACAGCTT TGGAAGATAA AGAATGTCTC 120

TCTCTCTTAT GGTTTGAATG TGTCTCCAAC ACTTTATGTG TTG AG AC TTC ATCCCCAGTG 18 0

TAACAGTATT GGGAAGTGGA G CCTTTAAG A GCTAATTAGG TCATGAGGAC AGCTCGCTCA 24 0

TGAGTTGACT AAAGCTGATA ATGTGGGAAC GTGTTGGTTA TCACAGGAGT GAGTTCCTGA 3 00

TAAAAAGAAT GAGTTTGGCC AGATTGTCTC TGTCTGTCTC ATCTGCCTGC TTCCACCTTC 360

TGTACTTCCA CCTGGAATGA CCCTCACCGG ATGCTGGTGC CATGCTCTTG GACTTCCCAG 420

CATCCAGAAC TTCTGTTTTT ATAAATTACC CAGTCTATGG CATTCTGTTA TAGCAGCAGA 4 80

AAATGGACAG AGACACCCTC AAATTAAAGG ACAGTCTTGC TGACTATGAA TTAGAAAATA 54 0

TCTGGGTTAG CTCGAG 556

(2) INFORMATION FOR SEQ ID NO; 1227:

(2) INFORMATION FOR SEQ ID NO: 1228:

60
120
175

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 175 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1227:

GAATTCGGCC TTCATGGCCT ACCTGCCTCG AAATACTACC GTATGGCCCA C CATAATT AC
CCCCATACTC CTTACACTAT TCCTCATCAC CCAACTAAAA ATATTAAACA CAAACTACCA
CCTACTTCCC TCACCAAAGC CCATAAAAAT AAAAAATTAT AACAAACCAC TCGAG

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 220 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO : 122 8 :

GAATTCGGCC TTCATGGCCT ACTGTTTCCT TGCCCTTTTC ACCGTCTGGT GGTTCCCTGC 60

499

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AGCCCTTGGC TTGTGGCCCT CTCATCCATC TTCCGAGCCT AGCACTCCAG TCTCTGCTTC 12 0

TGTCATCACA TCGCCTTCTC TTGAGAAAGA TCCCAGGCTG GTATTTAAAT TGCCTGTTGG 180
CAGGAACTTT GCCTGTCTTC CCCTACCCCC ACAGCTCGAG 220

(2) INFORMATION FOR SEQ ID NO: 122 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 526 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 122 9:

GAATTCGGCC TTCATGGCCT AAGTCTCT TG ACATCTCAAT TTACCCCAGA ACATCTCTAT 60

TTAATTATTC CCTGAGGAGG GGAAGTTGGG TATGGCGGTT GGAGGTGGAC AGGCTCCTAA 120

CAAGCACTTG CCAGCAGGGG GCACTCCCAG TTTTCGCTCC GCTGAGTCAC CCAACCCCTG 180

AGGCTTCGCC ACTTTCTAAT GTTTGCTGTG GCTACAATGG TCAGACCCAC AGGCAAAAAA 240

GTCGAAGTCC CTGGAGTCCC TGACCCCTCT TCCTCTCTAT AACGATTGGA AACTGTCCAA 3 00

ACCAACTCCA GTAGTTCTGG GCTGATGAAT CATCCTCTTG TGGGGCGGAG AGTGGGGGTA 360

GGGTGGAGCA ATGTGGGCTA GGACCCAGGG CAGG AT CAAA ATCTCTGAAG ATG CAGAGCT 420

CCCTCTGCCC TGGGAAGAAG GAAGCAGGAT TTATTATAAC ATTTAGCTCA CTGTCCAATC 4 80

GACTAAAACA AGCTCTCCCA GGGCTCGGGC CAACTGTCGA CTCGAG 526

(2) INFORMATION FOR SEQ ID NO: 123 0:

(2) INFORMATION FOR SEQ ID NO: 1231:

60
120
180
240
300
312

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 312 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 123 0:

GAATTCGGCC TTCATGGCCT ACCATTGGGC TATGACCTGA GGAGAATCAA GGTAGCTTTC
TCAGGCCTCG TGGACATCGT GGATATAAGG AATGCTCTCG TAGGAGGGTA CAAGAACCCC
AGCATGATTC CAATAGAGAA GGCCCAGGGG CCCATCCTGC TCATNGTTGG TCAGGATGAC
CATAACTGGA GAAGTGAGTT GTATGCCCAA ACAGTCTCTG AACGGTTACA GGCCCATGGA
AAGGAAAAAC CCCAGATCAT CTGTTACCCT GGGACTGGGC ATTACATCGA GCCTCCTTAC
TTCCCCCTCG AG

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 297 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1231:

GAATTCGGCC TTCATGGCCT AGCTTTATCC ACTCTGGAAT CCTGGAGGAG CCGCTACAAC 60
CAAGTTGTAA AAGAAAAGGG AGACCTTGAG NTGGAAATTA TTGTCCTGAA TGACCGGGTA 120

500

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ACAGATCTTG TAAACCAACA ACAAACCCTG GAG GAG AAG A TGCGGGAAGA CCGGGATAGC 180
CTGGTGGAGA GACTACACCG TCAGACTGCT GAGTATTCCG CATTCAAGCT GGAGAATGAG 24 0

AGGCTGAAGG CCAGCTTTGC TCCAATGGAG GACAAACTCA ACCAGGCACA CCTCGAG 2 97

(2) INFORMATION FOR SEQ ID NO; 123 2:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 360 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1232:

GAATTCGGCC TTCATGGCCT ACGCAGCTCT ACCTGCTCCA GGGGCACCTG GACCTGTGTG 60

AGCAGCACTG TGCCATCCTC CTGCAGACTG AGCAGAACCA TGAGACCGCT TCTGTGAAGT 12 0

GGAAAACTTG AAGACATTCC TGCCTTCTTT GAATTGGCCA AGAAGGTGTC TAGCCGGGTG 180

CCTTTGGAAC CAGGGTTCAA TTACTGCAGA GGTAT CTACT GCTGGCACAT AGGGCAGCCC 24 0

AACGAAGCCT TAAAGTTCCT GAACAAGGCA CGCAAGGACA GCACTTGGGG CCAGAGCGCC 3 00

ATCTACCACA TGGTGCAGAT CTGTCTGAAT CCAGACAACG AGGTTATGGT GCGGCTCGAG 360

(2) INFORMATION FOR SEQ ID NO: 1233:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 4 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi> SEQUENCE DESCRIPTION: SEQ ID NO:1233:

GAATTCGGCC TTCATGGCCT AGAAGGACTG AAATGATGTT ATACTAAGGG CTACTGAACT 6 0

TTTTGCCTGT TCTTTCCAGG TGTGACAGCC TTTTCTTTTC TTTCCAGGTG GTTCGCTTTG 12 0

AGGTGGTCTG AAGCCAAGGC CTCGCGGAGC TTCTTTGTGT GTCACCTTGC TTCCACGTTT 180

CAGTTCTTGT TTTGTTTCTA CTGCTTTAGT TTTTTTTAAA GTTCTCCAGT GTCCCCAAGA 24 0

GG TATTAGAA TCTTG CTGTA CCCAAGCAAG ACGTTAATTT TTCTTTTAAC TGTTTTGGGG 300

AGGGAGGGAG TGATAGCTTA ACTG CTGAAG CCAGGCGGGG GTCTGCTGGA GGATTCCAAC 360

AGAGAGTATT TCCTCCACTG TACAATGTCA CAGACTATCT CTATCATCAT TGCTTTGTGG 420

CAT 423

(2) INFORMATION FOR SEQ ID NO: 1234:

(ij SEQUENCE CHARACTERISTICS:

(A) LENGTH: 475 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1234:

GAATTCGGCC TTCATGGCCT AGCATGTAAA ACTTCAGTCC TGAACATTTA TAGGGTTTTA 60
TAGAAGGGCA TCCTCCAGGG CTGGTCCATT CAGAGAAATG CTGCATGCTG CCGTCATGGA 120
ATGTGGCCCA CAGGACACCA GAGCCGTGAG AACCGGAGAG CAGACTTCCC TCACGGCTGG 180

501

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PCT/US98/06956

GCTGAGCAAA CCCTCCAAAG CCCTCCTCAC GCAGTTACTA ACAATAGCAT GGGCTTACAG 24 0

CACAAGCACG TGTTCTCACC TTTTTCCTAT GCCCTGGACT AAGGTTTGGC CAGTGTAATC 3 00

ATATAAGGCC ATCCTGACAT TGTTTCTGTG TTTCAAAATT TGGATTTTTA TTTACATTAG 36 0

AACTACATTG CTCCTAGTAG AACATTACCT TTAGGGGACT AATTTTCGAT GGAGAACTAT 42 0

TTCAGCATAT TGCATGCTGC TCAGACCCCA AGTCAGATAT GCCCACAAGC TCGAG 4 75

(2) INFORMATION FOR SEQ ID NO: 123 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 01 base pairs

(B) TYPE: nucleic acid
(C^ STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 123 5:

GTTTTGAGCC TAGTAGCACT ACCTTCCAAG TGAGTCACAA CAAATTTGAT CCTATTTGGT 6 0

ATGTTTTTGT CCACTGTTAT GAT TN AT CAT GTATCTTACA AGAGCCACTC AAGCAAGACT 12 0

CTGCTTCTAT GTATGGTGAG GCCTNGTTGT TCTAGG CTAG AATAAACTCT TTGTATGCCT 18 0

CAT TG AATAT GCCAGGTAAA ATTTATGCAG TCAAGAATGA ATTATTTTTC TGACTAAAGT 24 0

GTGTAGCAGT AGTT CAAAAT TGTGCCCTTG TTTTAACAGT TTCTGTCNAC ACCTTCTCGA 300

G 301

(2) INFORMATION FOR SEQ ID NO: 123 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 346 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO ; 1236:

GAATTCGGCC TTCATGGCCT AAGAGAAGAT AACATTTACA AGTAAACAGT AAGTGCAATT 6 0

GTATTTTAAT TTCTTGGTCT CCGAAAACTC AGCTGTGACT GCTTTCCATT AACAG TTCCA 12 0

GCTCTATGTG TTTCCTCTAA CGCTAAAGGC ACAGCCCCCG GGAATCTACT GCTTCCTAAG 18 0

AGTCTCCATG GAGTCTATTT TACAACCTCC TTTCCCTCCA TGCTTCCGCG GAGGAGTCTA 240

TACTATCTCT ATATACACAT TTTAAACATT ATTCTTCATT TGAAATTCCT TCAATAAAAA 30 0

CACAGTCACC ATTCTTCATC TTCTTGGGAA ATGGCCTGCT CTCGAG 346

(2) INFORMATION FOR SEQ ID NO: 123 7:

(i) . SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 55 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1237:

GAATTCGGCC TTCATGGCCT ACTCACTATG TTGCTCAGGC GGATGTGGAA CTCCTGGGCT 60
CAAGCGATTC TCCTGCCTTG GCCCCCAAAG TG CTGGGAT T ACAGGTGTGA GTCATGGCAG 120
CCACGGCTCC AGAGCTCGGG TTCTTAATCT GGTCTGTGGA TGGCCCCTGG GGGCGGTCCC 1B0

502

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ATGAGCCCCT CACAATTGGA CACAGTTTTG CAAAGGGGTA AAAGGACAAG AATCGGTAGC 24 0

TGTGACTGTG GATGAGCCTC TGAGCTTCAC TTTCCCTCCC TGAAAGGGGG TGACAGTGGC 3 00

ACCTCCCTGG AGGTTTTCGT GGAGGGGAGG AAACACATGT AAAATACTTC ACCCC 3 55

(2) INFORMATION FOR SEQ ID NO: 123 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 560 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 123 8:

GAATTCGGCC AAAGAGGCCT ACTAGACCTG ATCACCACGT TCAAAAGTTG GCTTTCTCCA 6 0

TTTTAAGTTC TTCCTTAAAG CCTCTTTAAG CAAAGTCCCT GAAATGATAC AG TAG AAAAA 12 0

T CACACAG AC TTATTTAAAA TGAATTCTAT CACTATTCCT GAGATCTCGC CTGCCCCACT 180

GAGGACATTT TGTTTTCGCA AAGTGCTTTG AAATGTGATA AAGG AT CTTA AAGAATATTT 24 0

GTAAAATTAT GCCCAAAGAA GACATTCTTT GAGGTTAACT TGCAGTGTCT AAAAGTCAAG 3 00

AATGAGGAAG GAAAGGAAAA TAACAG AT T C ACTTTAAAAT GGACCACGCT AATTGGGCAG 360

TGAAACATCC TTGTGTCACA CCATTTACCG TAGCAGACCA GAAGAGGGAA AAGGCTTGAT 420

TTTTCTCTCA TAGATACCAC AGTTCACTCT CAAAAACATT CCTAAAATGG ATTGATATTT 4 80

CTCTGATAGA GCACCTGTTT TGCTACTGAC AGTGTTAAGT TCCATACTAA TCAGCTCATC 54 0

TAGCCTAACG ACAACTCGAG 560

(2) INFORMATION FOR SEQ ID NO: 123 9:

(2) INFORMATION FOR SEQ ID NO: 124 0:

60
120
180
240
300
360
420
480
54 0
56 9

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 569 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 123 9:

GAATTCGGNC AAAGAGGCCT AAGGAGAANG AGGCT CAGAA GGAGACGATT AAGGATCTTC
CCAAGATGAA CCAGGAGCAG TTCATT GAG C TGTGCAAGAC GCTTTACAAC ATGTT CAGTG
ANGACCCCAT GGAGCAGGAC CTGTACCACG CCATCGCCAC CGTGGCCAGC CTCCTGCTCC
G CAT CGG AG A GGTGGGGAAG AAGTTCTCAG CCCGCACAGG CAGGAAGCCC AGGGACTGTG
CCACTGAGGA GGACGAGCCA CCAGCACCCG AACTGCATCA GGACGCAGCC AGGGAGCTTC
AGCCCCCAGC TGCAGGAGAC CCCCAAGCCA AAGCAGGCGG AGACACACAC CTCGGAACAG
CCCCACAGGA GAGCCAGGTG GTGGTGGAGG GGGGCAGCGG CGAGGGACAG GGCTCACCCT
CCCAGCTGCT GTCTGACGAT GAAACCAAAG ACGACATGTC CATGTCCTCC TACTCGGTGG
TCAGCACGGG CTCCCTGCAA TGTGAAGACC TTG CAGACGA CACGGTGCTG GTGGGCGGGG
AGGCCTGCAG CCCCACAGCG CGACTCGAG

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 405 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

503

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PCT/US98/06956

(xi) SEQUENCE DESCRIPTION: 5EQ ID NO: 1240:

GAATTCGGCC AAAGAGGCCT AGAGACCAGC CTGGCCAATA CGGTGAAACC CTGTCGCTAC 6 0

TAAAAATACA AAAATTAGCC AGGCATGGTG GCTCACACCT GCAGTCCTAG CTACTTGGGA 120

GGGTGAGGCA GGAGAATCAC TGAAGCTTGG GAGGCAGAGG TTGCAGTGAG CCAAGATTCC 180

ACCGCTTCCC TCCAGCCTGG ATG AC AG AG T GAGACTCCGT CTCAAAAAAA CAAAAAAAAA 24 0

GTTACTTCAA TAATGTACTT TTTTTTTTCA AATTACAGAT AATCTATAAG GAATTAATCT 3 00

TGAAATTAAT TCCAGGTTTA ATTGTTAATG AAATTTCACA AGCCTAATTT AACACTTGTC 360

TGGATAACTC ATTTTGATAC TGAGTAAATA GTCACCGGTC TCGAG 4 05

(2) INFORMATION FOR SEQ ID NO : 1241 :

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 54 2 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1241:

GAATTCGGCC AAAGAGGCCT AGGGCTTTTG TGAATAAATT TTAAAAGAGA CTACTGCCTG 60

TCCTTAAATT CCTTTTTCTT TTTATAAAAA AAGAACTATT AAAAATGATT GACAAATTTT 120

GAGTTAAAAA ATTGTTAAAA CATTCTCTAT ATTTAATTTC AATTTTATAA TAGATTACAG 180

GAAGATGCTT ATGAAACAAA TACATTTGTT TCAGTACATG TCTTTAAATG ATAGACTTAT 24 0

AAGTATGTAA ACAACTATAT AATAAAAGGT TTCCAAACGC TGCCTGTAAG AAATCAGGCA 30 0

AATTTTACCA TAAGCAATAA ACCATTCCAA GCCTTCCAGA CAGTCTCCAT AGCCGCACCA 360

GCATGGCAAT AAGCTTTAAC CAAACGAAAA CAAACAAACA AAAGCACTTC GCAATTTGTT 420

GCTGCAAAAC AGGGAGAGAA AAGAG TGTAC AAACTTGATG GAATCACAAC AGTCAATATA 4 80

ATTTAAGGGA CAATAAAGTC AATAAGGTTG ATGGTGTTTA TTGTTTAAAA AGTTAGGCCT 540

CT 542

(2) INFORMATION FOR SEQ ID NO: 1242:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 370 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1242:

GAATTCGGCC AAAGAGGCCT ACTGATACAA TTGTTGACTT TTCTTTTACT ATGTGTAAGA 60

AATACCCCAA ACATGAAAAG ATTGTTTTGA TCATATGCAT GTATGTAGAA TATTTTTGCA 12 0

GAGCAGAAAG ATTATGT TAG AAGTGTGATT TTTATTTTCA GAAGTCATAT ACATGTAAGC 180

TACAATTTTG AGTGCTTTAT AAACACTTAA GATATATATA TAAATTTTAA TTTCATAGCA 24 0

ACTTGTAAAA AATAAAATAC TTGTTGAAAA GCCTTTTTCA ACATATCCCT AAGCTAAGGG 300

AAGAGGAAGG AATAACAACT CAGTGAAAAG ATGGTCTCCA GTTTCTGAAT GAAAAAGCTA 360

CAACCTCGAG 370

(2) INFORMATION FOR SEQ ID NO: 1243:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 3 74 base pairs
(B> TYPE: nucleic acid
(C) STRANDEDNESS: double

504

WO 98/45437

PCT/US98/06956

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1243:

GAATTCGGCC AAAGAGGCCT AGCCTCATCA CGGGCAGGGC TCTGGCCCAT AGTGGCTGGA
CAGACACTGG CACAGTCTTG CTGGTCTGCT GGGAGCACAC AGACATTGGC ACAGACTTGC
TGGTCTCTTG GAAGAGGGCA AGACC CC AAA CCAGAGCAAA ATACACTTCC AGCTCTTAAC
CAGGCTCCTT CCAGTCACAA GTGTGCAGAA TCAGAACAGA AGTAGTACCA ATCAATGTCA
CATGAACAAA CAAGCTGCCC CCAGGGTACC ATTTGGGGAG GGGAAATCTT TTCTTTCTTT
CCCCCTTAAA AAAAAACACA TCTGCCCCGA ACACTTTCCC ACTGTTATTC TTTCCTCATA
CCCCAACGCT CGAG

60
120
180
240
300
360
374

(2) INFORMATION FOR SEQ ID NO:1244:

(i) SEQUEL ZE CHARACTERISTICS :

(A) LENGTH: 468 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1244 :

GAATTCGGCC AAAGAGGCCT ACACACCAAA CTGATTATCC ACCAGACACT CAGCGTCTTA 60

GAAGATATTG TGGAGAATAT CTCGGGGGAG TCCACCAAGT CTCGACAGAT TTGCTACCAG 120

TCGCTGCAGG AATCTGTTCA GGTCTCCCTG GCCCTCTTTC CAGCTTTTAT CCAT CAGTCA 180

GATGTGACTG ATGAGATGCT GAGCTTCTTC CTCACTCTGT TTCGAGGCCT TAGAGTACAG 24 0

ATGGGTGTGC CTTTCACTGA GCAAATCATA CAGACTTTCC TCAACATGTT TACCAGAGAG 3 00

CAGTTAGCCG AGAGCATCCT CCACGAGGGC AGCACAGGCT GCCGGGTGGT GGAGAAGTTT 360

CTGAAGATCC TGCAGGTGGT GGTCCAGGAG CCAGGCCAGG TGTTCAAGCC CTTCCTCCCC 4 20

AGCATCATCG CCCTGTGCAT GGAGCAAGTG TATCCCATTT CGCTCGAG 46 8

(2) INFORMATION FOR SEQ ID NO:1245:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124 5:

GAATTCGGCC AAAGAGGCCT AAGCTTATGG GGAGGACACA TATTTACTCA AACATCCTGG 60

CAATTCATAT CTAGGGCACT CCCTCTGTGT GTCAGACGCC CTTGCATGTG TCAAATGTCA 120

TCTGATAACA TTGATGAAAA ATATCATTCA CTTCTTCTTG GTGCAGAAGG CATAGACCGG 18 0

ATTATGCAAT CACTGAGAAG TAGCTTCTGG ATGTGTTTTC TGGTGGCGTC TTAACAATTT 24 0

CAG CCGACTG AAGGCTCTTG GACACTTGGA ACATTTGTAG GGTTTCTCTC CGGAGTGGAT 300

GCGCTGGTGC TCCTTCAGGC TCCCCCTGTA GGTGAAAACT TTCTTGCAGT CTTTACATTC 3 60

GAAGGGCTTC TCCCCCTGTG TGGCTTCTCT TGTGACACTT CAAGTAGGAC TTCTGGGTGA 420

ACTGCTTAGG CCTCTTTGGC CGAG 444

(2) INFORMATION FOR SEQ ID NO: 1246:

(i) SEQUENCE CHARACTERISTICS:

505

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(A) LENGTH: 431 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1246:

GAATTCGGCC AAAGAGGCCT AGTATTTTGT ACTAGTTTTT TAATAATTAT AAGTCTTACA 60

CGTTCTCTAA TTCTTCTTGA ATCTGTTTAA TTTTTCTCCC TTGGGAATTG TTAAGTGTAC 120

ATGTATTGTG ATAACTGCTA TAATTTTGCT TTTATTGATT TTTTTTGCTT TATATCTGCT 180

ACAATTTGGT TCCTCCAAAT CCCATGTTGA AATCTGATCC CCAGTGTTGC TGGGGGATCT 24 0

AATAGCAGGT GTTTGGGTCA TGGGAACAGG TCCCTCATGA ATGAATTAAT GCCCTCACTG 3 00

GGAGGAGGGG ATAAGTAAGC TCTCACTCAT TTAGTTCCCA AGACAGCTGG TTGTTTAAAA 360

GAGCCTAGTG CCACTTCTCT CTTGCTTCCT TTCTTGCCGT GTGATCTCTG CACATG CCAG 420

CTCCCCTCGA G 431

(2) INFORMATION FOR SEQ ID NO: 1247:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 89 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

Cxi) SEQUENCE DESCRIPTION: SEQ ID NO: 1247:

GAATTCGGCC AAAGAGGCCT ATTTTTTTTT TTTTTTTTTT TTTTTTTTTT TCNGGGTGTA 60

GAACATTTAT TTATTTTTCC CACAAATCAC TGAAAGTTTA GGTCAGTGGG AAATAATTTT 120

AATCAAATAA TTGTACATAT TCTTCCCACA TATCCTGCCT TGTATTAGGA AATGACATTG 180

TGATCCATTT CATTACAAGT AAAATATTAC AAAATATTTA CAGGAAAATA TTAAAAATAA 240

CTCAAACACA AAAGG CAAG A TGAAATAAAC TGTTTT TTTT TCTCCAGAAA TCTCTACTCC 300

AGTGCCCACA GCACACAAGA GTCAAAACAA ATAAGCAACT AAGATCCCCC GAT CACAAAT 360

TTCCAAAGAA CTAGGCCTCT TTGGCCGAA 3 89

(2) INFORMATION FOR SEQ ID NO: 124 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 80 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124 8:

GAATTCGGCC AAAGAGGCCT AAAGGAAGGC CACTTCTCAA CTGGCAGAAC TTCTGAAGTT 60

TAGAATTGGA ATTACTTCCT TACTAGTGTC TTTTGGCTTA AATTTTGTCT TTTGAAGTTG 120

AATGCTTAAT CCCGGGAAAG AGGAACAGGA GTGCCAGACT CCTGGTCTTT CCAGTTTAGA 1'80

AAAGGCTCTG TGCCAAGGAG GGACCACAGG AGCTGGGACC TGCCTGCCCC TGTCTTTTCC 240

CCTTGGTTTT GTGTTACAAG AGTTGTTGGA GACAGTTTCA GATGATTATT TAATTTGTAA 300

ATATTGTACA AATTTTAATA GCTTAAATTG TATATACAGC CAAATAAAAA CTTGCATTAA 3 60

CTTAGGCCTC TTTGGCCGAA 380

(2) INFORMATION FOR SEQ ID NO: 1249:

506

WO 98/45437

PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 86 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 124 9:

GAATTCGGCC AAAGAGGCCT GTTTGGTTTG TGACTAGACT TAAAAATACT AAAATAAGCC 6 0

AAATAGATGC TAACAATACT AATTTGCACA CAAGATTTGA AAAAAGTACT TCAAGTTTTA 12 0

TCTCTTATCC CTAGAGAAAG TAAATAAAAA GTGGCTCTTG CAAAAATAAA TGAAAACAAA 180

ACCACCAACA AAAACTAATC ATATAAGATA CTGTTTTTCT TTTTGAATAC TTCAATTGGT 24 0

CCTATATTAG GATAAGGTTT TGATAGCAAG GACTTCCTAG CTTCTTCCTT TATCTTCCAT 3 00

TCTCTAGTCA CTTCCGTGTT TTTATCAAAC AAGGCTACGT GTAGGCTTTC CTACAAAGTC 3 60

AGATTGAATT CTACCACCCT CTCGAG 386

(2) INFORMATION FOR SEQ ID NO: 1250:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 42 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:12S0:

GAATTCGGCC AAAGAGGCCT AACCATGTCT GACCAGATCA TTGGGAGAAT TGATGATATG 60

AG TAGTCGCA TTGATGATCT GGAAAAGAAT ATCGCGGACC TCATGACACA GGCTGGGGTG 120

GAAGAACTGG AAAGTGAAAA CAAGATACCT GCCACGCAAA AGAGTTGAAG GTTGCTAATA 180

ATTTATACTG GAATCTGGCA TTTTTCCAAG CCAAGAGAAG ATCGAATGGC TTTTTGCAGC 24 0

TAACTACTAT GTGTAGACAG GTTTTATATT ATAAAGTATG CATTCTTATC ACCTAGTATA 3 00

TAGTTAGTTT GTAGAGTGAT TTCCCCCCAG TTTCTTGAAC ATGGTATCTT CACATCTTGG 360

ACCTTGGTCA GTTGTGCTAT TCATTATTAA ACACTAAAAC TTTGGCGGTT TAGGCCTCTT 420

TGGCCGAA 428

(2) INFORMATION FOR SEQ ID NO: 1251:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1251:

GAATTCGGCC AAAGAGGCCT AAGAAAAGTA GTATGAATGA GTTTTTCTAC ATATTAACTA 60

CAATTTATGG TAATTTGTGA AATGTTTTTC CATTTTTAAA TGTAAGAGTC TCTATCTCCA 120

CTCACAAAGC AACAGGCACT GCTAGGGGTC TTAGGCTAAC ATCTGCCACC CCACCAGTCT 18 0

GCATGGCCCA TAAACAGGTG CAGAGGACCA GAGTTCACCT GTCAGCAGCA CCGCAGAATC 240

CAACTCTAGG CCTCTTTGGC CGAA 264

<2) INFORMATION FOR SEQ ID NO: 1252:

507

WO 98/45437

PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 36 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO : 12 52 :

GAATTCGGCC AAAGAGGCCT ACTTTTTTTT TAATTTTCCA CTTTCTTCTT AACTTTACTT 6 0

CTCTTTTTGT CCCCCCCCAT CTTACAGAAG TTGAGGCCAA GGGAGAATGG TAGGCACAGA 120

AGAAACATGG CAAACTGCTC TGTGCTTTCA AACCAAAGTG TTCCCCCCAA CCCCAAATTT 18 0

GTCTAAGCAC TGGCCAGTCT GTTGTGGGCA TTGTTTTCTA CAACCAAATC TGGGTTTTTT 24 0

TCTTCTTTCT TTAAACATAG AGGTACCACC ACAAGGGATG CCCTACTCTC TCGCAGCTCT 3 00

TGAAAGCATC TGTTTGAGGG AAAGGTCTCT GGGCAAGCAA GTGGTTATTT GGATTGCTTG 360

CTTCCCTTTT TCCACCTGGG ACATTGCAAT CATAAAATAA CAGTAAATTC CAAACCTCTA 4 20

GGCCTCTTTG GCCGAA 436

(2) INFORMATION FOR SEQ ID NO: 1253:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 399 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1253:

GAATTCGGCC AAAGAGGCCT AGGGTAGATC ACTTGATATC AGGAGTCGAG GCGGGAAGAT 6 0

CACTTGACGT CAGGAGTTCG AGACTGGCCC GGCCAACATG GTGAAACCGC ATCTCCACTA 12 0

AAAATACAAA AATTAGCCTG GTGTGGTGGT GGGCACCTGT AATCCCAGTG ACTTGGGAGG 180

CTAAGGCAGG AGAATTTCTT GAAC CCAGG A GGCAGAGGTT GCAGTGACCA GCAAGGTTGC 24 0

GCCATTGCAC CCCAGCCTGG GCGATAAGAG TGAAAACTCC ATCTCAAAAA AAAAAAAAAA 3 00

AAATTCCTTT GGGAAGGCCT T CTACATAAA AATCTTCAAC ATGAGACTGG AAAAAAGGGT 3 60

ATGGGATCAT CACCGGACCT TTGGCTTTTA CAGCTCGAG 3 99

(2) INFORMATION FOR SEQ ID NO:1254:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1254:

GAATTCGGCC AAAGAGGCCT ACCCGGTACT TACTTCTCAA TCCTAAAGAG AGAAAACAGG 6 0

TGTTTGATCA GTATGTAAAG ACCAGGG CAG AGGAAGAACG CAGGGAAAAG AAAAATAAAA 120

ATGCAAGCCA AGGAAGATTT CAAAAAAATG ATGGAAGAAG CAAAATTTAA TCCAAGAGCA 180

ACTTTTAGTG AATTTGCAGC CAAGCATGCT AAAGATTCAA G ATT CAAAGC AATTGAAAAG 240

ATGAAAGACC GAGAAGCCTT GTTTAATGAG TTTGTGGCCG CTGCTAGGAA GAAAGAGAAA 300

GAAGATTCGA AGACCAGAGG TGAGAAGGTA AGATGGTTTT AGTTCCAGTG GTGTGATTGA 3 60

TGGGAGTGTG AATGGGAAAG GTCTATGCTG GTGTTATGTT TCTAACCTTA TTCATTGGCA 42 0

TAAATAATAG GACGTACACT CGAG 444

508

ill III 111 iliittllHIlll

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(2) INFORMATION FOR SEQ ID NO: 1255:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 84 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1255:

GAATTCGGCC TTCATGGCCT AAGAAGGACT ACCCTGCACT GCTTTCCTTG GAT G AG AATG 6 0

AACTCGAAGA GCAGTTTGTG AAAGGACACG GTCCAGGGGG CCAGGCAACC AACAAAACCA 120

GCAACTGCGT GGTGNTGAAG CACATCCCCT CAGGCATCGT TGTAAAGTGC CATCAGACAA 180

GATCAGTTGA TCAGAACAGA AAGCTAGCTC GGAAAAT CCT ACAAGAGAAA GTAGATGTTT 24 0

TCTACAATGG TG AAAACAG T CCTGTTCACA AAGACAAACT CGAG 284

(2) INFORMATION FOR SEQ ID NO: 1256:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 91 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1256:

GAATTCGGCC TTCATGGCCT AGTGGGAGTT TG CTAATGTG AAACCTAATG ATGTCTGAAA
ATGGTCCTGA TGGGTATTAA TAG CCATCTG GAAAAATTTT ACATCTTCAC AAATAATCCC
AATAATTTAT ATTGTGAAGA TATTATCCTG ATAGTCCTTC TTTTCCTATA TTCTTGTCGG
CTGTAGGATG AGAGCAGTAT GAAGCAAACA GAAGACATTT TGAAATTAAT CACAAAATT C
CCATTGCTTT GAAGCCTGCT ATTATTATAC TAAGCCTTCT TATAGCTTTA AAAATCAAAC
AATGCCAAAC AGTATATCTA ACATTTTTAA TTTCCTTTGA GCCAAACCAA TTTGGTTTAA
ATTTCTCTGC CTCCGTGAAG ACAAGCTGGG CTGGGGAGGA CGGTGTCTAG GAGGGATGAC
CCCACTCAGC TCCAGGCAGT GTTCTGCCGA GACCCCAAGA ACTCGGGGTG TCAGAGGGCA
AAGGAACTAC CTGCCTTTCA CGGCTGCTGA CTTCTCAGGG CTGCAAGCAG CACAGAATGT
TAT CCTTACG TCCTGAGCCG GTTTAAGTCT GTGGAAAAGG AAGCACGGGA GAAATCCACG
TAACCTTTGC TTTCTTTTTA AGGGAAGCGG TTCCGCCGTG AACTTGGAAC CCTCAGCTCC
GGGTGTTCTC GGCAGAAGGG CAGCTCTCGA G

(2) INFORMATION FOR SEQ ID NO: 1257:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 83 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1257:

GAATTCGGCC TTCATGGCCT AAGCTGATCC ACGAT CAG AG TGCTCCCAGC TGCCCCAGCA

GCTCCCCGTC CCCAGGGGAG GAGCCTGAGG GGGAAGGGGA GACAG AT CCG GAGAAGGTGC 120

ATCTCACCTG GACCAAGGAC AAGTCGGTGG CAGAGAAGAA TAAGGGCCCC AGTCCTGTCT 180

CCTCTGAGGG CATCAAGGAC TTCTTCAGCA TGAAGCCGGA GTGGGAGAAC TTGAAC CAGT 24 0

60
120
180
24 0
300
360
420
480
540
600
660
691

509

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CCAACGTGCG GCGCATGCAC ACGGCCGTGC GGCTGAACGA GGTCATCGTG AAGAAATCCC
GGGACGCCAA GCTTGTTTTG CTCAACATGC CTGGGCCTCC CCGCAACCGC AATGGTGATG
AAAACTACAT GGAGTTTCTC GAG

(2) INFORMATION FOR SEQ ID NO: 1258:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 418 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

{xi} SEQUENCE DESCRIPTION: SEQ ID NO: 1258:

300
360
383

GAATTCTGAG
CATTGCCTCC
TTACAGCCTG
GAATCTCCTT
AACTCTTCCA
TGATGACGAT
AT CT CACCAT

GGACTAACTA
TCCCTCCCGG
CACCCAGATC
GCGCCACAGA
AGCAATTCCA
GGAGACCATG
TCCGATGAGT

CGACCATGAG
TGAAAGTGAC
CTATAGCCAC
ATGCTGTGTC
ATGAAAGCCA
CAGAGAACGA
CTGATGAGAC

ATTGGCAGTG
TGATTCTGGC
ATGGCTGGTG
CTCTGAAGAA
TGACCACATG
GGATTCTGTG
CTTCACTGCT

ATTTGCTTTT
AGCTCAGAGG
CCTGACCCAT
AAGGATGACT
GACGACGATG
GACTCGGATG
AGTACACAAG

GCCTATTTGG
AGAAGAAGCT
CTCAGAAGCA
TTAAGCAAGA
ATGACGATGA
AATCTGACGA
CAGTCGAG

60
120
180
240
300
360
418

(2) INFORMATION FOR SEQ ID NO: 1259:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 18 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1259:

AAAAATTAAA TAATGCTTGA CTTTTTTTTT TTTTTTTCTC TTTTTGAGGC AGGTTCTTGC
TCTGTCACCC AGGCTGGACT GCAACAG CAT GATCTTGGCT CACCTCCGCC TCCCAGGCTC
TGGCAATCCT CCCACCTCAG CCTTCAGAGT GGCAGAGACT ACAGGCTCAT ACCACCGCAC
CCACTCGAG

(2) INFORMATION FOR SEQ ID NO:1260:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 78 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1260:

60
120
180
189

G CG ATTGAAT
TATAACAGGT
TTCTTATGGT
TGGGACAAGG
CTCAACCTCC

TCTAGCCTTT CCTCCGTTCA AGTAAATTTA GAAATTTCCT AAGTTTTCTT 60

AGCCTAAATC TATATCATAC TTTTAAAATA AAAATCTAGG TGCAAATTTG 120

TAAGGTTAAC ATGTACACTT CACAAACATT GAGACTTTTG TTTTGTTTTC 180

TCTTGTTCTG TCTCCCAGCT GGAGTGGATA CAAG CATGGC TTGCTTCAGC 240

CGGACTCAAG CGATCCCCCC CCCTCGAG 278

510

I

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(2) INFORMATION FOR SEQ ID NO: 1261:

(i) SEQUENCE CHARACTERISTICS :

{A) LENGTH: 26 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1261:

GAATTCGGCC TTCATGGCCT ACTCACTGGA TGCTGGGGGA GGGCCCCTCA GGTGAGCAGC
CCACCACTGA CTTCAGCGTT GCTGGCTCGG TTAT C AG ACT CTCATCCAAC ACAAGCTCAC
AGGGAAAGCC GTTCCTTGCT CCTTGTGGAG GGAGCTACCG TCATTGCCCT GAGACCACCA
GCCAAGAAAG TAGGTATGTC CAGGTAGGGA ATTCAGAGGG ACCCAGTGCA TCCAATTATA
CAATTATACC CAGAAAGTCC TCGAG

(2) INFORMATION FOR SEQ ID NO: 1262:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 42 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1262:

60
120
180
240
265

GGTCAGTATT
ATGCAGGGTG
GAATACTGAT
AATCAGTAGC
CAGTTGCTAC
TTGGTTGGTG
AGGTCGGCCT
C TCGAG

GAAGGTTGTT
AGATGGTAGT
TGCTGCAGAT
ATGCGCCGCT
CACAGCAGGA
AATGATGTGC
CAGGACTGTG

TTCTGAGCCA
GTGATTCTTG
GGAGGATGCT
GTCGTAGTGA
GGGATGG CAT
TGTACTGCTG
GTTACTTTAG

TTGTATGAAG
TTGTGACATC
GGATAGACAA
TGACTGGAGA
TGGAGGTGGT
GCTGAGCAGT
AACTGGACAT

CTGCTGTTTT
TCGTGACTGG
GGTTGGCCTA
CTGAGCTCTG
CACAGGTGGC
AGCAGCATTT
CACAGCAGCA

GGCGTCCCTA
GCAGGACGCT
CTAAGTG CTG
GTGGCTGAGA
CGAGACTGGA
GGCAGCTGTG
G CAG CTG CAC

60
120
180
240
300
360
420
426

(2) INFORMATION FOR SEQ ID NO:1263:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 98 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1263 :

GAATTCGGCC
TCTCTCCAGC
TGGCACCACA
ACACTGATGT
CGGTGGTTTC
TTGAGGAACT
GTAGGCTTTG

TTCATGGCCT
TGGTGGTGAA
GAAGCAGGGC
CTTGGATCTG
CGTCCACAAT
GCAGTGCCTT
GCAGTATCTC

AGGCCGGTGT
GTTGTGTACA
ATCCTTGGCT
GAATCGAAGG
GTCATGGGAG
GTCCACGTTC
TCCCGAGAGC

TTATGCACGA
TTGACGTTGG
GACTTCTTCT
ATGATGGTCC
CCCATGTTTT
TCCAGGCAGT
ACCTCGAG

TGGCGTTGAA
GATAAC CTG C
CCTTGTTGTC
AGACCAGCCC
CCAAGTGCAC
GGATCCGCAT

AG CTAGTCCA
AGTCTTCATC
TTCTGTCTCC
AAGGGTCAGT
TTTCTGCTCC
GCGGCCCTTT

60
120
180
240
300
360
398

511

(2) INFORMATION FOR SEQ ID NO: 1264:

<i> SEQUENCE CHARACTERISTICS :

(A) LENGTH: 256 base pairs

(B) TYPE: nucleic acid

(C) -STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION • SEQ ID NO: 1264:

GAATTCGGCC TTCATGGCCT AAAAAAAGCT GTTAAGAAAA TATGTTTTAA AAATTTGCCC
AACAGGAAGG AGAAAATTAG AATCTAATAG CAAACT TGTG TCAAAG CAGG GGAGACCACA
TGATCTTCCT CTTTGAAAAT CTGTCCTGGG TGATGACCAT ATGCTCTCTA AACAGGTTTT
CTGTGTTTTA GGGAAAGAAG CTCAGAAAGG ACCCCTGCTC TTTGATGACC TCCCTCCGGC
CAGCAGTAAC CTCGAG

(2) INFORMATION FOR SEQ ID NO: 126 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 9 base pairs

(B) TYPE: nucleic acid
IC) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION ; SEQ ID NO: 1265:

GAATTCGGCC TTCATGGCCT ACAGAGTCTA ATT AG CCATA TTTATATGAT AATAATAAAC
ATTTTGGCTA CAGTCCTACC TAGATTTTTT TTTTTTAGAT GGAGTCTTGC TCTGTCGCCC
AGGCTAGAGT GCAGTGGTGC GATCTTGGCT CACTG CAACT TCTGCCTCCC AGGTTCAAGC
AACTCTGTTG CCTCAGCCTC CCAAGTAGCT GGGAT TACAA GCGCACATGA CCACGCCTGG
CAGCTCGAG

(2) INFORMATION FOR SEQ ID NO:1266:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 265 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1266:

GAATTCGGCC TTCATGGCCT AGGTTATATA GCAGTGATGC TTT CAT AGTA TTTTTCTTGA
ATAAGGTCCC CAAAACCTTA TTAAGTTCCT GGTAGGCATG GAGCATTGAA GATGGCAGAC
ATGGTGCAGT CTCTCAAGGA GTTTACGCTC TAGTGGAGAA AACAATCAGA CAG C CTT AAA
ATACATGTAT GGCTACTATA ATAAATACTG TGAAGCAGGA GTGCACCACG AAACCTGGAG
TCCTCTCCAT CCTCCCCTTC TCGAG

(2) INFORMATION FOR SEQ ID NO: 1267:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 93 base pairs

(B) TYPE: nucleic acid

512

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(C) STRANDEDNESS : double

(D) TOPOLOGY': linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1267:

GAATTCGGCC TTCATGGCCT AC TAG AC CTG C CT CG AG AT T AGGGGGGTTA G ACT CAG AAT 60

TCTGTCCAAA CTCCTGGACG ACCTCTTGAA ATTAAGTCAG GGATTTTATG TACTGGGTTA 12 0

ATTTCGTAAC CTCTGGGTAT AATATTAGGT TTG CATG TAG AAAGGGTCTC CAGTATAGGA 180

CTTCAAAGAA ACTAAGCCAT AGACGTAATT TAAGGGCTGT TCTGATCTGA AGAAGTGCCA 24 0

TGGGTAGAAG TTTTAGCCAT GGTAAAGAGG CTTCCTGGCA TCATTTGCTC GAG 293

(2) INFORMATION FOR SEQ ID NO: 126 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 501 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 126 8:

GAATTCGGCC TCATGGCCTA CTGGTCCAAG CTGATTACCC TCATAGTGTC CATCATTGAG 6 0

GAAGACAAGA ATTCCTACAC TCCCTGCCTC AACCAGTTTC CCCAGGAGCT GAATGTGGGT 120

AAAATCAGCG CTGAAGTGAT GTGGAATCTG TTTGCCCAAG ACATGAAGTA CG CCATGG AG 180

GAGCACGACA AGCATCGTCT ATGCAAGAGT GCCGACTACA TGAACCTCCA CTTCAAGGTG 24 0

AAATGGCTCT ACAATGAGTA TGTGACGGAA CTTCCCGCCT TCAAGGACCG CGTGCCTGAG 3 00

TACCCTGCAT GGTTTGAACC CTTCGTCATC CAGTGG CTGG ATGAGAATGA GGAGGTGTCC 360

CGGGATTTCC TGCACGGTGC C CTGGAG CG A GACAAGAAGG ATGGGTTCCA GCAGACCTCA 420

GAGCATGCCC TATTCTCCTG CTCCGTGGTG GATGTCTTCT CCCAACTCAA CCAGAGCTTT 480

GAAATCATCA AGAAACTCGA G 501

(2) INFORMATION FOR SEQ ID NO: 126 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 33 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ i i ) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 126 9:

GAATTCGGCC TTCATGGCCT AGGCCCCTGC TCCACCTGGG GGGACTGGGA GTGTGAGTGT 60

GCATGG CATG TGTGTGGCAC AGATGG CTGG GACGGGTGAC AGTGTG AG TG CATGTGTGCA i20

TGCATGTGTG TATGTGTGTG TGTGTGTGGC ATGCGCTGAC AAATGTGTCC TTGATCCACA 180

CTG CTC CTGG CAGAGTGAGT AACCCAAAGG CCCCTTCGGC CTCCTTGTAG CTGTTTTCTT 240

TCCTTTTGTT GTTGGTTTTA AAATACATTC ACACACAAAT ACAAATTGAC AGGTCAAAAT 30O

CCATGAAATG AGATCCCCCA GCGGCTCGAG 33 0

(2) INFORMATION FOR SEQ ID NO: 1270:

(x) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 502 base pairs

(B) TYPE: nucleic acid

513

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(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1270:

GAATTCGGCC TTCATGGCCT AAAAAAAAAA TACTGATTCA CTTTTGCAAT TTTTCAGATA 60

CTACTTGATG TGACACCTCC CCTAGGCTTG CTGTGGGTCT CTTGGAAGAT AG AG CTATAT 120

TAACTCCTTG ACTTAAAGGG CAGCAGACTA TATAAGGTCT CTTTACAGAC AGAGTAGGGA 180

GAATAATGAA AAACTTTTTG ATTTCTAGAG AGAAGAGAGA AGACATAGCA ATGGAACTGT 240

TCTTAGCTTT GTTTGCTACA ACTCTTCAAA GTTTAATTTT AGATTCAGTG CATTTATTCA 3 00

TAGAG CATGA AACATATAAT CATGCCTTTT ACTAATTGCG GATACTTAAA ATTATATATT 3 60

TTTGACCTAC TGTGTTATGG TCAATTTGAA AAAGAATGGT TTG AT TATAT ATTATTGTCT 420

GTAGATTCCC TGTACTATTC TAGGATCATA TGACATATTA TCATTACTAA ATATAGCACT 4 80

AATTATTGAT GCTCCGCTCG AG 502

(2) INFORMATION FOR SEQ ID NO: 1271:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 85 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1271:

GAATTCGGCC TTCATGGCCT ACCCCTGACT ATTCAGTAGG AG AAGAAAT C AAAAATCCAT 60

TCTTTTCTCC TTCTCTCCCT CCAACAGTGG CCAGGGGAAG GGGAAGTGAG GGCAGGGGCA 120

AAAAGATTTG GGAATTTTTA TTTATTTATT TAT TGTG ACT TTT CATTTTT TTGGTATTTG 180

GCTTTACTGG AATAGGAGGG CCCCTGCCCA CTGTGCCCCG TTTATCCCTT ATT CCCCAAA 240

CCCTGCTCTC CCCAACACCT ACTCACTTAA GCACTTGTCC TCGAG 285

(2) INFORMATION FOR SEQ ID NO: 1272:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 05 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 1272:'

GAATTCTAGA CCTGCCTCCA ATTTGAAGAT TTATTTCTCT CTTTGGATAT AGAACAAAAT 60

AACTTTATGT ACATTTTATT TCACTTTATT TTACTATTGG GTTGGTGCAA AACAAATTGC 12 0

AGTTTTCCCA TGAAAAGTAA TGGCAAAAAC TGCAATTACT TTCGCACCAG CCCAATATTT 180

TATTTTGAGA CAGAGTCGCA CTCTGTCACC AAGGCTGGAG TGCAGTGGTG TCATCCCAAC 24 0

TCACTACAGC CTCTGCCTCC TGGGTTGGAG AGATTCTTGT GCGTCAGCTT CATGTGTAAC 3 00

TGGAATTACA GGTGCACGCC ACCACGCCCA GCTAATTTTT GTATTTTTTG TAGAGATGGG 360

GTTTCGCCAT GTTGCCCTGG CTGTTCTCAA ACTCCTGACC TCGAG 405

(2) INFORMATION FOR SEQ ID NO: 12 73:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 412 base pairs

514

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PCT/US98/06956

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1273:

GCGATTGAAT TCTAGACCTG GCTCGAGGCA GGTCTAGAAT TCAATCGGCT TCCTGGCAGT 60

GCCCTCTCCC AGATGAGACC TGATCTCTTT TTTGTTTTTT GTTTTTTGTT TTGAGACAGA 12 0

GTTTTGCTCT TCTTGCCCAG GCTGCAGTGA GTTGAGATCG CACCACTGCA CTCCAGCCTG 180

GGTGACAGAG TGAGACCCCA TCTCAAAAAA AAAAAAAAAA ATCTGGCCTT ATGGACTGTG 24 0

TACTACACTC TAGTGGGGGT AAGAGGCAAT GGGTAAATAG GTAAGTAGAT TATTGGATGT 3 00

ATTAGAAGGG GCATGGGGAA TGTGGGGTCA AGGTTATAGT TTTAAATAGG GTGGTCAGGG 3 60

AAAGCTTTCT GAGAAGGTGA CATTTGAAAC AAATACTTGA AGGAGTCTCG AG 412

(2) INFORMATION FOR SEQ ID NO: 1274:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 28 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1274:

GAATTCGGCC TTCATGGCCT AGCTATTTTT AAACAATATC TGAGATTATT CATTCAACTA 60

AAAC TTATTA AG CATTTAAT ATCTGTCTGG CATTCTTCAG GCACCAAGGA TATTTCGTTG 12 0

AACAAAACAA AATCTTTGTC ACTATGGAGT TTACGTTTTG TGGTGGCATT GGAGTGAAGA 180

GCTAGGGAAT AAAAAAACAA GTCAATATGT AGTATG CCAC TTGGTGGTAA GTCATTTGGA 240

GAATGATGTA GTAGGGAAAG AGGAAAAGGG TGTAGGCATC TCGAG 285

(2) INFORMATION FOR SEQ ID NO: 1275:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 280 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1275:

GAATTCGGCC TTCATGGCCT ACTCCACACA TTCATCTCCC AAAGGACTCC TTGAATATTT 60

GCCCCAAAAC ATCAGCTCCC AGAAAACACC CCTCCCAGTC ACACACACAC CCAAATTCTC 120

CGATGTATTT TCATTTTTTT TCTCCTCTTC TCTTCTCTTT TTCCTTCCTT CCTTCTCTCT 180

TTTCTCTCTT TCCATCCCTC CCTTCCTTCC TCCCTCCCTT CCTTCCTCCC TCCCTTCCTT 24 0

CCTCCCTCCC TCCTTTCCTT CCTCCCCCCA CCCACTCGAG 28 0

(2) INFORMATION FOR SEQ ID NO: 1276:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 220 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

515

WO 98/45437 PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1276;

GAATTCGGCC TTCATGGCCT ACGAGTGGTG CGATTTTTTT TTCTTAGCTT AT CAGCTATG 6 0

GTTAGTGTTA GCGTATTTTA TGTGCGGCCC AAGACAATTC TTCCTCTTCC AGTGTGGCCC 12 0

AGGAAAGCCA AAAGATTGGA CACCCCTGGT AGAGGCAGAA ACTCACTGGG TTAGTTCCAC 18 0

AG CAT CTG AT CAAAGATATG AGGCCAAAGA GCCTCTCGAG 220

(2) INFORMATION FOR SEQ ID NO: 1277:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 246 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1277:

GAATTCGGCC TTCATGGCCT ACGAG CTG AG ATTGCGCCAC TGCACTCCAG CCTAGGCAAT 60

AGAGTAAGAC TCCATTTCAA AAAAAAAAAA AAATGTTGAT CAAAAGAAGC CAGATGACAG 120

AGTACTCACT GTGTGAGTCC ATT TATTTG A AATTCTAGAA CAAAAAATAA ATATCCATTG 180

ATAGAAATGG GAACAGTGTT GGCCTATGAA GAATGGAAAT TGACTGGAAG GAGGCCTCTG 24 0

CTCGAG ■ 246

(2) INFORMATION FOR SEQ ID NO: 1278:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH - 4 99 base pairs

(B ) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1278:

GAATTCGGCC TTCATGGCCT AGCTGGGCGT GATGGCGGGC GCCTGTAGTC CCAGCCACTC 6 0

GGGAGGCTGA GGCAGGAGAA TGGCGTGAAC CCGGGAGGCG GAGCTTGCAG TG AG C CAAG A 120

TTGCGCCACT GCACTCCCGC CTGGGCCACA GAGAGAGACT CCATCTCNAA AAAAAAAAAA 18 0

GAAAGAAAAA AAGAAAATAA ACAAAGAAAA AATTAAGATT TTTGAAATAA AAACAAATAT 240

TAAAAATTAT TGAAATATAT TGAAAGTTTT TTCACCATAT ATATTTACCT TTTAAAAGGA 300

TATGAATTCA ATTATTTTAT TTGCTTATGG AAAATAGATC CACTGCTCTA AGATGCTACT 360

AATCATGCTC AGAGGATTCA CAACAAACAG ACTGATAAGG TATTACTTAA AGCGCTCTAC 420

ATTAAATAGA GCATTCCAGT TTTCTAGGGC ACACTAC TTG CTGTATTTCC AAGGTCAAGC 4 80

AAAATAG CTT TCGTTCGAG 499

(2) INFORMATION FOR SEQ ID NO: 1279:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 317 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

516

WO 98/45437

PCT/US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 127 9:

GAATTCGGCC TTCATGGCCT AATGAGCTAA AAGCAGTGTC ATCTCCGCAT GTTGGAGCAG 60

CCAAGAAATA GTTTGGTACT ACCGACATTG TCTAATCCAT GTCACATCCT CATACAATTT 120

AATTGCTCAA CCATGCATTT AAAACTCCTC AAGAAAGGAT TGGTACTGCA ACTGTAGGTA 180

AACTGAAAAA AAATAAGAAA GAAAGAGTTG GATGAAAATG TGAAAGCCCA AG TTTAGATG 240

TGCATTAAGT ATTAAATAGC ACAGTATCTT CTTCATGGAG CCTTTTTTCC TCCCCCATCC 3 00

CCTGCAGCTA CCTCGAG 317

(2) INFORMATION FOR SEQ ID NO: 1280:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 07 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO.-1280:

GAATTCGGCC TTCATGGCCT ACTTCCTTTC ATTTTGAAGC AACAGTTTAT AAACAGGAAA 60

GTCTACTGGT TTCATAGAAT CTGTCAGATT TGCTTATTTG CTACTGGTTT CACGCGCGTG 120

GACTATATTC CAGTGTTTCT AGTCAAAGAC CTTTATCCTC AAATCATGAG ATTAGAGTAA 180

AACAACTGCT GTAAGGTTGA GCATTTCATG ACCAATGACT ATGAAGGCAC ATTCACCAAA 24 0

CACAGGCACT TTAAGGG CAT CCTTGATTAA TTTGCTAATT GCTATTTTTT GTTGGTATGT 300

GAATTCCTGC TAGGAGGCCG AGGCTAGTAG GCAATGAAAA AGACAGAACA ATGGTAAAAT 36 0

GCAGCCCCCG TCCTCTACAA ATTGACAGTA TAATTTAGGG GCTCGAG 4 07

(2) INFORMATION FOR SEQ ID NO: 1281:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 281 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 12 81:

GAATTCGGCC TTCATGGCCT AAGATTGACA AAGAAATAGA GCTTCACAGA ATTCTTCATC 6 0

ATAAGCATGT AGTGCAGTTT TACCACTACT TCGAGGACAA AGAAAACATT TACATTCTCT 120

TGGAATACTG CAGTAGAAGG TCAATGGCTC ATATTTTGAA AG CAAG AAAG GTGTTGACAG 18 0

AGCCAGAAGT TCGATACTAC CTCAGGCAGA TTGTGTCTGG ACTGAAATAC CTTCATGAAC 240

AAGAAATCTT G CACAGAG AT CTCAAACTAG GGAACCTCGA G 281

(2) INFORMATION FOR SEQ ID NO:1282:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 250 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 82:

517

■feiikliiil

WO 98/45437

PCTYUS98/06956

GAATTCGGCC TTCATGGCCT AG TAGTT T AT TATATAGAAA TTATTTGTCC TTGTCTTAGT
TGTGCCCTTT GACTCAGCAA TTCCCCTTCT ATAAAATTTT CCCAAG CAGA TGATTATGGA
TATATGCACC AATTTGGAAA CAGGGATGTT TATTGTTTAT AGTAGCACTC AACTGAAAAC
AACATAGTTG TCTTCAGGAG CGGGGACTGA TTAAATTATG ACATGAAGCA GAATAATGCA
AAATCTCGAG

(2) INFORMATION FOR SEQ ID NO: 12 83:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 257 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 83:

GAATTCGGCC TTCATGGCCT AGCTGAAGAA GGCCTTCACA GAGCTTCAAG CCAAAGTTAT
TGACACTCAA CAGAAGGTGA AG CTCGC AG A CATACAGATT GAACAGCTAA ACAGAACGAA
AAAGCATGCA CATCTTACAG ATACAGAGAT CATGACTTTG GTAGATGAGA CTAACATGTA
TGAAGGTGTA GGAAGAATGT TTATTCTTCA GTCCAAGGAA GCAATTCACA GTCAGCTGTT
AGAGAAGCAG TCTCGAG

(2) INFORMATION FOR SEQ ID NO: 1284:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 34 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID N0:1284:

60
120
180
240
250

60
120
180
240
257

GAATTCGGCC
TAATT TGCAT
GAAAGGTATT
CCTTTATCAA
TAGTTAATTA
GCTACAAAAC
TAACATTAAT
GCCAAAAACT

TTCATGGCCT
TCGCAAATGA
TCTCTGCAAG
TAAAGATGAA
G CATCTGG AA
TGTAAGTTTG
AGTGTAGAAT
CGAG

AAAGACTAGC
GACTGATAAA
ATTTCTGGGG
AATCCGCAAT
ATGAGGATTA
ATCCATGTGG
ATTTAGATGT

ATATTTATCT
AATGGATTTA
CTATCGTTTC
TTGCATTAGT
T CTTAATTAC
AAATTGGTAA
AATTTG CATA

TTGACTTGAT
CCTTTTAACC
TTAACCGATA
GAATGGGACT
AAAGCACAAT
CATTATTATG
TGCAAATGTG

TAATCAGACC
TTTAGAGGAG
AGAAG CCACT
GATTATTATA
TTCCCTAATA
TAATTAGTGA
ATTTACCTGA

60
120
180
240
300
360
420
434

(2) INFORMATION FOR SEQ ID NO: 1285:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 02 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1285:

AG CAATATTT ATTTTAGACA GACTTCTGCG TTATGACCCG GCTGCTGGGC TACGTGGACC
CCCTGGATCC CAGCTTTGTG GCTGCCGTCA TCACCATCAC CTTCAATCCG CTCTACTGGA

60
120

518

WO 98/45437

PCT/US98/06956

ATGTGGTTGC ACGATGGGAA CACAAGACCC GCAAGCTGAG CAGGGCCTTC GGATCCCCCT
ACCTGGCCTG CTACTCTCTA AGCATCACCA TCCTGCTCCT GAACTTCCTG CGCTCGCACT
GCTTCACGCA GGCCATGCTG AGCCAGCCCA GGATGGAGAG CCTGGACACC CCCGCACTCG
AG

(2) INFORMATION FOR SEQ ID NO: 12 86:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 245 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1286:

GAATTCGGCC TTCATGGCCT AATCTTTTCT AATTTGTCTT AATGCTTTAT AATTTTCTAT
GCAGAGGTCT TGTAGATCTC TTTCCAAGAT ATTTGATGTT TGTTTGTTTG TTTGTTTGTT
TGTTTTTTGA GACGGAGTCT CACTCTGTTG CCCAGGCTGG AGTGCAGTGG CGTGATCTTG
GCTCACTGCA ACCTCCGCCT CCTGGGTTCA AGCAATT,CTC CTGCCTCAGC CTCCCAAGTC
TCGAG

(2) INFORMATION FOR SEQ ID NO: 1287:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 232 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 87:

GAATTCGGCC TTCATGGCCT AATTTTTTTT CTCCTCTTTC TTCTAGTACA TATTGATAGG
TATAACATAA TTAAGGTTTA AAAAAAATTA GACATAGTTA TTCAGATTTA GGACCAGTAA
GGATAGAACT TTCTCTTATT TATGAAAAAA AATG CTAATA ATTTTGGGGC AGTTTTTTCC
TTTAATTATT TTTTTCAATT TCAAGTTTAA TTTTATTTTA GCTGATCTCG AG 232

(2) INFORMATION FOR SEQ ID NO: 1288:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 98 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1288:

GAATTCGGCC TTCATGGCCT ATAGGCCATG AAGGCCGCCT TCATGGCCTA AGAAGATCAC 60

TTGAATCTGA GAGGTAGAGG CTGCAGTGAG CGAAGATCAC ACCACTGGAC TCCAGCCTGG 120

GCAACAGAGT GAGACC CTGT CTCAAAAACA AAGAAGAGCA CTAGCTTCTC TATCAAGTAA 180

GTGTAGGGTT TTAAAAAACA CAAATGGACT TTGGTAGACC AAAACAAAAG CCCACGAGTA 24 0

TGGAAGTTTC CCTTGAAGTT GGAAATT CAA TTTCCCCCTT ACCCCCCCAA CCCTCGAG 298

(2) INFORMATION FOR SEQ ID NO: 1289:

519

180
240
300
302

60
120
180
240
245

WO 98/45437

PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 7 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi> SEQUENCE DESCRIPTION: SEQ ID NO: 128 9:

GCGATTGAAT TCTAGACCTG CCTCGAGCCA TACCCATGGT CAGCCTCTTC CTCGTGTTCA 60

CGGCCTTCGT CATCAGCAAC ATCGGCCACA TCCGCCCGCA GAGGACCATT CTGGCTTTTG 120

TCTCTGGCAT CTTCTTCATA CTATCGGGCC TCTCCTTGGT GGTGGGCTTG GTTCTTTACA 180

TCTCCAGCAT CAACGACGAG GTCATGAACA GGCCCAAACA GCTCGAG 227

(2) INFORMATION FOR SEQ ID NO: 1290:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 264 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1290 :

GAATTCGGCC TTCATGGCCT AGACAACTCT T AG CTAAATG TGGTTTGGTT TTGAGCTGGA 6 0

AGAGAGTACA AGGTG CTTCC GGAAAGCTTC AAGCCTTCGG ATTCTGTGAG TACAAGGAGC 120

CAGAATCTAC CCTCCGTGCA CTCAGATTAT TACATGACCT GCAAATTGGA GAGAAAAAGC 180

TACTCGTTAA AGTTGATGCA AAGACAAAGG CACAGCTGGA TGAATGGAAA GCAAAGAAGA 240

AAGCTTCTAA TGGGAATACT CGAG 264

(2) INFORMATION FOR SEQ ID NO: 1291:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 23 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1291:

GAATTCGGCC TTCATGGCCT AGGTGCTCTC AAGGATCAGT ACTGGGTAAC AATAATCAAA 60

CTTTGAATTT AAACATGCAT CTATTATTTG TGTTTTTTGT TTTTGTTTTT GAGGCAAAGT 120

CTCACTCTGT CACCCAGGCT GGAGTGAAGC AGCCCAATCT TGGCTTACTG CAACCTCCAC 180

CCCCTGGGTT CAAGCAATTC TCCTGCCTCA GTCTACCTAG TGGCTGGGAT TACAGGCGCC 240

CGCCACCACG CCCAGGTAAT TTTTGTGTTT TAGTAGAGAT GGGGTTTCAC CATGTTGGCC 3 00

AGGCTGGTCT AGAATT CAAT CGG 3 23

(2) INFORMATION FOR SEQ ID NO: 1292:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 289 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

520

WO 98/45437

PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 92:

GCTCGAGAAA CTTCTGCTGC ACGTGCGTCT TCCCCTCCAC CTTCACCCCT TGTGGCTCAC 6 0

TCACGCACCC ACTCTCCAGT CCACCCCTCC TCAGAGACCC TGTCCACTCA TCCATCTCTC 12 0

TCCCATTGCG CTTCCTCTTC ACTCCGTTCC TTCTGCCTCC CACCATATGC AAATCTTCTC 180

CATC CTTAAA AGCCTGATTG CCTCCTCTGG ATTTTTCCAC ACTCTTGGGG AACTTCCTGT 24 0

GACTCCCTGC CCTTCACCAC CAGCCTTTCC CAAAGAGAAA TCCCTCTCA 289

(2) INFORMATION FOR SEQ ID NO: 1293:

(i) SEQUENCE CHARACTERISTICS :

{A) LENGTH: 421 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1293:

GAATTCGGCC TTCATGGCCT AGTTGAAATC TTTAGGAATG AACTTCTGAG GGCCAAAAAA 6 0

TGTGACTGAC GGGAACAATT CTTAAACTGA TTAACTAGCT GTAATATAGT TTTGTGAATT 12 0

TATTGCACTG ATGTTGTACC TTGTGGTATA TCTGTCCCTA TTAAATAAGT GTTGTTTTCT 180

CCTCTTTAAT ATTG CTGTGA ACAGTGGTGC CCATTGTAGC ATATGTTTGA TTTTTTTTTA 24 0

TTATTTCATA AGAAAACTAC GTTAATTTTA CCTTACTTTC ATTGTAAATA AGCCTGTCTT 300

CCTATCTGGA TTTTTTGTGT G CATACAT AT TCTACTGATT AACTACTTTT GCAGTTTTAA 360

TCCTGTATTA TTTCTTCTAC TTTGTTTTGT GTAAAAGGGG AAAAAATAAA AAAAGCTCGA 420

G 421

(2) INFORMATION FOR SEQ ID NO: 1294:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 408 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1294:

GAATTCGGCC TTCATGGCCT ACAGGTGTAT GTCACCATGC CTGGCTAATT TTGTTTTTCT 6 0

TTTCTTTTTT TTTTTTTCCT AGAGACAGGG TCTCACTATG TTGTCTGTCC TGGCTGGTCT 120

CAAACTCCTG GGCTCCATCT TCCCGCTTCG GCTTCCTGAA GTGCTGGGAT TACAATAGGC 18 0

ATGAGCCACT ATGCCCATCC TAAAGTTTTA CAGCCCAATA ATAGTAATAT TCCATCACTA 24 0

CAGCTATCAT TGAGT TTCAG AAGTTAGACT GTTAAAAGTT T C AGTAAAG A GCTTTAACCA 3 00

GTTTATTGTG GCAATACTGT GTACACAATT ATTTTTTGTA AAAGGAAGGA GATTTCTGTC 3 60

TTAAATAGCT TTAATAAAGT TTCAGTTTCA TATACAGGAA ACCTCGAG 4 08

(2) INFORMATION FOR SEQ ID NO: 1295:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 259 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

521

■llMUM

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PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1295:

GAATTCGGCC TTCATGGCCT ACAGGCACTC CAGTTATAAT TATGTGCCTT TCTTCCATTT
CTACCACTTT CTCTGATACT TCTCACTTCT TTCTCTGGTA CTTCTCACTT CTTTCTCTGG
TATCATTTTC ATTCTTCATC ATTGTTTTAG TGCCTTTACT TCAATTCCTT CATTATTTGA
ATTTTTCTTT TTATCATCTT GTGATTCAGT TTTTATTTAT TTTTTGATAG TATTCTCCTT
TTCTTCCATT CCACTCGAG

(2) INFORMATION FOR SEQ ID NO: 1296:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 57 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1296:

60
120
1B0
240
259

GAATTCGGCC TTCATGGCCT AGTGGAGAGT GCTATCATTA ACACCTGAAC TCTGGGCCAG
CTTAAGTGTA TATT CTGTAA AAAATTTGAA ATCCCCCAAA TGTCACATGC TATGACAG TC
ACTTTCTTTA GTACTTTGTA ATCATACAAA ATGGTGTATG GGCTAAATAT TGCAGCACCT
ATGTCGTCAT CCTCCATGTT GCTTATTGAT CATGGAATGT TAATT TAGCA ATAATTTTCT
CTGTGTGTGC GCTCGAG

(2) INFORMATION FOR SEQ ID NO: 1297:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 327 base pairs

(B) , TYPE : nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 97:

GAATTCGGCC TTCATGCAAG TAGGGTATGT AGGCTTCAGT TGGTTCTACT TTCAGAGAGT 60

TAAGATGGAA TGAGGCAGCT CATGGCACTA CAGGTCAGTT GCCTTCTCTC CAAAATGTTC 120

ACTCATG CAT GTGGGCACTC ATTGTATTTG AATAACAGCA ACAGTGCCTC CCTCAGTTTG 180

GAACCTCTAG TCCACTTGCT CACTCATGGT CCCTGCCTTA ACCCCAGTCA AGTTCAAAGC 240

CATAGGCATC ATTTGTCCGA CTGACATATT AGGGCATCTA CCAGTCAAAG GGTGATTGTT 3 00

GTAGATGACC TTTGGCCCGT TCTCGAG - 3 27

(2) INFORMATION FOR SEQ ID NO: 1298:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 286 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12 98:

60
120
180
240
257

522

WO 98/45437

PCT/US98/06956

GAATTCGGCC TTCATGGCCT ACACTCTCAT GTTTGTTGCA GCATTATTCA CAATAGCCAA 6 0

GGTATGGAGT CAACCTGAAT GTCGAACACA TGAATGGATA AAGAAAATGT TCACACACAC 120

AATGAAATGT GATTTAGCCT TTAAAAAGAA GGAAATCCTG CCATTTGGAA CAACATGGAT 1B0

GAACCTGGAG GGCATTGTGC TAAGTGAAAT AAACCAGACA CAGAAAGACA AACACTGCAT 24 0

GACCTCACTT ACTGTGGAAC CCCTCGAATT CTGGATCTCC CTCGAG 286

(2) INFORMATION FOR SEQ ID NO: 1299:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 85 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1299:

GAATTCGGCC TTCATGGCCT AATGAATTTA GTATTATTTC TATCATTTCA ATTGCAAATT 6 0

GTCAGTATCC CCTGCTACGT TTCTACTAAT TTACCATCGC TTCTTCAAAA AATTGTGTTC 120

AG AG TGCTAC AATTTCAGAC TTTGAAATGA ATCACTATAA CTTTTAAAAA TTAGAGATTT 180

TAAAAACTGG AGATTGAATA TATATAAAAA ATACAAAATT TGACATTTAA AACCTCATTG 240

AACTTTTAAA AAAGCCAGAC TCATATTAAG GCACACACCC TCGAG 285

(2) INFORMATION FOR SEQ ID NO: 13 00:

(i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 00:

GAATTCGGCC TTCATGGCCT AGGGCCAATG GCCAGGATCT CTGGGGACTA GAAGGGTGGA 60

TTCCTGAACC TGGGTAACAA CGAGACAAAC TCTAGCAATC TGAGCAAGGG AAGGGTCATC 12 0

AAAGTCCCAA AATCTAGCCC ACTAGCTGCC TAGCCAGGTA AACCAAGGCT TAGGGAGTTT 180

AGACCCTTTC ACATAAAGAA GCTTAATAAA AAGTGTTGGG TGAAGAGATA AACACATGAA 24 0

GGGGTTGGCT AAAGTCAAAA GAAGATCCGA GGCAGGTCTA GAATTCAATC GG 292

(2) INFORMATION FOR SEQ ID NO: 1301:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1301:

GAATTCGGCC TTCATGGCCT ACTCCTCATT TGCCACCACC AGGCCAGTTT GTCCCTTTCC 6 0

AAACACAGCA ATCACGATCG CCTCTGCAAA GGATAGAAAA TGAAGTGGAA CTCTTAGGAG 120

AACATCTTCC AGTAGGAGGT TTTACTTACC CTCCATCAGC CCACCCCCCA ACATTACCTC 180

CATCAGCTCC CTTGCAGTTC TTAACACATG ATCCTTTGCA TCAGGAGGTG TCCTTTGGAG 24 0

TACCTTATCC TCCATTTATG CCTCGGAGGC T TACAGGAT A GTAGATACCG ATCCCAGCAG 300

523

WO 98/45437 PCT/US98/06956

CCAATACCAC CTCCCCCTTA TCATCCCAGC TTACTGCCAT ATGTGTTATC AATGCTTCCA
GTGCCACCTG CAGTGGGCCC AACTTTCAGC TTTGAATTAG ATGTAGAAGA TGGAGAAGTA
GAAAATTACG AGGCCCTGTT AAACCTGGCA GAG CGACTGG GAGAGGCAAA GCCTCGTGGA
CTGACTAAAG CAGATATTGA ACAACTTCCT TCTTATCGGT TCAATCCTAA CAACCACCAA
TCCTCGAG

(2) INFORMATION FOR SEQ ID NO: 13 02: .

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 84 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION • SEQ ID NO: 13 02:

360
420
480
540
548

GAATTCGGCC TTCATGGCCT AGTATCTATC TAGTGCCTGT TTGTGCGTTT TTTTCTTTCT 60

TCCGCTGCTT CCCCATTTTC CTTCTGTCCT TTTTCTCCTG CTCCTTGTTT TCCCAGCAGC 120

ACATGGGGTT CCTCGGAGGA GCAGAGGTGG CCGCCGTGGG GGGGCGTTTG GGCTGCGGTG 180

CTGCGTCATT TTTCCTTTGC TTTCTCTTTA CTTTAGACAC TGGCCCAACT CCAGGCGTTT 240

CCTTTCATTC CCTCAGTGCT TCTCTTCTGA CCTGCATGTT GAGTTCTGTA TTGCTGGGGC 3 00

TTCCAACAAA AACCAGAGTC AC TGACAG AG GGAACAGCAG AGACCTTGTT GGTATTCAGC 360

TGTGATGGAT ATAGCGATCT CGAG 384

(2) INFORMATION FOR SEQ ID NO: 1303:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 14 0 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 03:

GAATTCGGCC AAAGAGG CCT AGGGTACGTG AATCTATTTT TTCAGCTGGA AATTTTATGA 60
AATCTGGTGT GTATTTTATA CTTATAGCAT ATCTCGAGGC AGGTCTAAAT TCAAT TCTAG 120
ACCTGCCTCA AGAGCTCGAG 14 0

(2) INFORMATION FOR SEQ ID NO: 13 04:

(i) SEQUENCE CHARACTERISTICS :

(A} LENGTH: 620 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 13 04:

GAATTCGGCC AAAGAG G CCT AAATAAGTTT ACTTTTATTT TTGGTAACAC TTTACTG CAT 60

TGTCTGAATA TTGACAATCA GTATG CATTA TGAAGCTACC TGGCTAACAT TGTGTACTCA 120

CTGTGTGTGC CAGGCCCTGG GTTCAATGCT CTACATGCAC TTATATTTCA TTTAATTCTC 180

TCTGCAACCT GAGATGGTAT AGCCACCTCA TTTTACAGAG TTGAAACTGA GGCTCAGAGA 24 0

CTGAAAGTTA AGCCTGAGGT TGCAGTCAAT AAGAGGCAGA GCTGGAACTG AAACCTACCT 3 00

524

WO 98/45437

PCT/US98/06956

GTGTCTGACC ACCAGTTCGT GTTCTGACGG CAGGCTAGTC TGCATCACAG AGTGTGGAGT 360

AGATGGTGCA TGCCTGCTAG GATGGGCTAG GTATCACTGT AGGTAAGAAA CAGCCCCAAA 420

CTATGGAAAT GTACACCACC GAAGGCTCTT TTCCTGCCCA TGCTGCACAT CCTCCATGGC 4 80

TCTCCTGTGC CCTGTGCCCC ACATGCCCTC ATCCTGCCAC GAGAATAAAG GAGCAGCCTC 54 0

CATATGGGAG CTGTCAGCTG CTCTAAGAGA TGAAGGAGAG AGTGGCCCGT CTCAATGGCT 6 00

CCCAACTCTT CTGCCTCGAG 620

(2) INFORMATION FOR SEQ ID NO: 130 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 73 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 1305:

GAATTCGGCC AAAGAGG CCT ACTTTTGGCT CAATGTTTTC CAAACTTATT TGACCCCAAA 6 0

ACCTTTTTCA TATACCCAAT AATAAG CTAC AGAACTAATA TTCTGCAAAT GTCTCTTGGA 120

ACACACTGCC TTAAACAGAT ATTTCTATAG CTGT CAGTAT AGT TATGTTG CTCCCAAGCC 18 0

TAGTTATCTC CAGTTGTTTT AAGGGTGTTA TGAAAAATTC TTAAAATATA TATGAATTTG 24 0

TGTAACACAC ACAGAGACAC ACACACATAC TACTTTAAGG GGGTGAGGAT CATTAATTCA 300

GATAATTTTT AAGTTTCCTA GTGATTCTCA ATCTCTTTGA ATTTTACTTA CATTTACACA 3 60

CACACGCACA CACATATGTA TATACACATA TCATTTTAAG AAGCTGAGGA TCACTAATTC 420

AGATAATGTA TAAGTTTCCC AGTGATTCTC AACCTCTTTG AATTTTACTT ATAATTACAT 4 80

ACACACACAC ACTGCTACTT ATATAAATGT TCTCATGTAA TCATGGTAAC AG CT CAAATT 54 0

CCCAAAGCAA GGGAAGACTT CTCATTGTCA GTTAAACCTG TTAAAACATG AAAATATTCA 600

TTGAGCCTAG TTCCTTGTTA TAAAATACAA GAAATAAGAC ATTCAGG CAT TTTCCCTTTA 660

TGAAGATGTT CAGTCAT CCT TTCCTTGAAC TACAATTAGG AAAAGTATAT GTCTTTATTC 720

CATTGAAGTT CTCGAG 736

(2) INFORMATION FOR SEQ ID NO: 1306:

(i) SEQUENCE CHARACTERISTICS J

(A) LENGTH: 511 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 06:

GAATTCGGCC AAAGAGGCCT ACAG CAATAT GCATCTTGCA CGTCTGGTCG GCTCCTGCTC 60

CCTCCTTCTG CTACTGGGGG CCCTGTCTGG ATGGG CGGCC AGCGATGACC C CATTG AG AA 120

GGTCATTGAA GGGATCAACC GAGGGCTGAG CAATG CAGAG AGAGAGGTGG GCAAGGCCCT 180

GGATGGCATC AACAGTGGAA TCACGCATGC CGGAAGGGAA GTGGAGAAGG TTTTCAACGG 240

ACTTAGCAAC ATGGGGAGCC ACACCGGCAA GGAGTTGGAC AAAGGCGTCC AGGGGCTCAA 3 00

CCACGGCATG GACAAGGTTG CCCATGAGAT CAACCATGGT ATTGGACAAG CAGGAAAGGA 3 60

AGCAGAGAAG CTTGGC CATG GGGT CAACAA CGCTGCTGGA CAGGTTGGGA AGGAGGCAGA 4 20

CAAACTGATC CATCATGGGG TCCATCACGG GGCCAACCAG GCGGGAAGTG AGGCAGGGAA 4 80

GTTTGGCCAG GGAGTCGACA ATGCACTCGA G 511

(2) INFORMATION FOR SEQ ID NO: 1307:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 219 base pairs

(B) TYPE: nucleic acid

525

WO 98/45437 PCT/US98/06956

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1307:

GAATTCGGCC AAAGAGGCCT AATTTTTCCC CACACCACAC CACTGTCCTC TGTGCCTGTG 6 0

GAAACCACTC AAATG CCTCT CCCCAAGCCT TCTTTCAGTA ACAACCATCT CAT CCGGTTG 12 0

ATTACTGTAG CTTTCGGCCT GTATAACCCC TCCTTATGTC ATGCCTGTAC CAGATGTTCC 180

ACTGCATCTG TATCCCACCA GATTGCACAT ACTCTCGAG 219

(2) INFORMATION FOR SEQ ID NO: 13 08:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 44 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1308:

GCACTGCGCC TGGCCCTTGT GGATACTTTC TAGGTGATTT GAGGAGGAAA GGCACAGCCA 60

TGTCTCCTAA AGTTAACAAG CACTAAG CTT TCCCAAGTAG TGAAATGTCA AGCCTCTGCT 12 0

TCTGTCACTT ATTTGTTCAT T CAG CAG AAA GTCACTGAGA GCCTTCTGTA CACCAGGCAC 180

AGTGCTGGGC AGTGAAAGAG ACAGACATGT CCCTGGATCC AGGGAGGAGA TGACCAAGTG 240

ATGGCTGTCA GGCCCAGACC TTGCTGTTTG TCTGCAGCCT CTTCCCTCAG GCAACTTGTT 3 00

CTCTATCAGG AGAAATGAAA TAATTATTAT CTGGAGCTCT CGAG 344

(2) INFORMATION FOR SEQ ID NO: 13 09:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 56 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 09:

GAATTCGGCC TTCATGCCTA AAAAGGGTCA GAGGAAGGCA GTATCCTTGG GGTGTTGCTG 60

AAGTTGAAAA TGGTGAACAT TGTGATTTTA CAATCCTAAG AAATATGTTG ATAAGAACAC 120

ACATGCAGGA CTTGAAAGAT GTTAC TAATA ATGTCCACTA TGAGAACTAC AGAAGCAGAA 180

AACTTGCAGC TGTGACTTAT AATGGAGTTG ATAACAACAA GAATAAAGGG CAGCTGACTA 24 0

AGAGCCCTCG AGTTGCAGGG AGCCCAGATC ATGCCACTGC TCTCCAGCCT GGGTGACAGA 3 00

GCAAGACTCT GTGCCCCCCC CCCACCCCAA AAAAAAAGAA AACAAAAATT AAAATCTTTA 360

GTTACTGTAT TATTCAAAAA TGTCTACTTT CAAGAAAAAC TACAGC CATG CAAAGAAACA 420

GTAAAATGTG ACCATACTCA GGAAAAAAAG CAGACAATAG AAATGGCTTC TCAGTAGGGC 4 80

TATATGTTGG ATTTAGCAGG CAAAGACTTC AGAGGCCTTT TAATAAGTAT ATTCAAAGAA 540

TTACAGGAAA ATATGAAAAC TCGAG 565

(2) INFORMATION FOR SEQ ID NO: 1310:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 104 base pairs

(B) TYPE: nucleic acid

526

WO 98/45437

PCT/US98/06956

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1310:

TGCACAGCTG TAGTACCCCA AGAAGAAAAT GTTACTTCTC TCATCTGGGC AAAACCCACA
GAAGACTTCC CAGCTTCTGC CACATAAAAG ACACAGAACT CGAG

60
104

(2) INFORMATION FOR SEQ ID NO: 1311:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 105 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1311:

GAATTTTGCG TTCTGTTTAG CATGCTATCC TGTGTGAAAG AAACTGAAAT CCAATATTAT 60
GGAG AG TATG TTAAAGC CAC CTCTGAAATG AAGACCACTC TCGAG 105

(2) INFORMATION FOR SEQ ID NO: 1312:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 407 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1312:

GAATTCGGCC TTCATGGCCT AAAGGGAAGG GAGGTGTGAG GAGGATGGAG TAAGAGTGAG 60

AGGTC CTAAG AACATGGAGG GAGGCTGTGT GTGATCGATG GAGAAATATG GTCCTGAGAG 120

ATTTCTTGTA GTCAAGAATG GCCAATACAT GTCTACCTTT AACTGGTATT GGAAGGAAGT 180

AGTTTCCTGC TCTGTGCTCT AAATACTCTC TATTACCCTC AAGATGTCAG CAAAATGTGA 240

TACATAGCAA TCTTGTGTTA GAGATGCTTT AGGAATTGCA GAAAAACCAT GCTATCAAGT 3 00

GGTAGGGAAG TGAGTGGCAA GAGGATGTCT GTCACAGAAA CTAGGGATAG AGGGGCTGGC 3 60

AATGGCAGAG ATGCAGGTGG AGTGGACTGA TTAAGGGGAG TCTCGAG 4 07

(2) INFORMATION FOR SEQ ID NO: 1313:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1313:

GAATTCGGCC TTCATGGCCT AGGTCTTGCC ACATTGGCCA GGCTGGTCTC GAACTCCTGG 60

527

WO 98/45437

PCT/US98/06956

GTTCAAGTAG TCCTCCACCT CAGCCTCTCA AAGTACTGGG ATTACAAGCG TTGAGCCACC 120

CTCCCAGCCT TTGCCTTTTT TTT TTTTTTT TTTTTTTTTA GGAGGAGAAT TAATTGATAC 180

ATAGACCCCT TAAGAGAAGG GATGCTATGG GCAGGAAGAG ATTGAAGGTA AAGGAAAAAG 240

GATTCAGCAC CCAAGCAAAA CAATTGGCCT GTGATAGAAG GGCGATCTCG AG 292

(2) INFORMATION FOR SEQ ID NO: 1314;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 309 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1314:

GAATTCGGCC TTCATGGCCT AGATCCAAGA AGCTCAACAG ACCTCAAGTA GGATAAACAC 60

AAACAGATCT TCACTAAGTC CTACTG CTGA AAGACAAAGA CGAGGAGAAC ATCTTGAAAG 120

CAGTGAGAGA AAAACAACTC AT TATGGAG A GAGCAATGAT AAAATTCTTA TCAGAACAGT 180

GGAGGCCAGA AGGAAATAGA GTGACATATT CAAAATG CTG AAGGAAAAAT TTGCAACTAC 240

AAGTTCTAGA TCCAGCAAAA TTATCCTTCA AGAATGAAGG TTTAG TAAAG ACATTCCCAG 3 00

ACCCTCGAG 3 0 9

(2) INFORMATION FOR SEQ ID NO: 1315:

(i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 469 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1315:

GGCCCCAGCT CCTGAGTAGC TGGGATTACA GGCATGCACC ACCACACCCA GCTAATTTTG 60

TATTTTTAGT AGAGACAGGG TTTCACCATG TTGGTCGGGC TGGTCTCAAA CTCCTGACCT 120

CAGTGATCCA CCCGCCTTAG CCTCCCAGAG TGT TAGAATT ACAGGCGTGA GCCACTGCAC 180

CCGGCTGGGA AACATTTTTA AAACGGCGCA GGGTTGTCCT TGAAAGTCCC AGGTTTCCTC 240

ATTGGCCCTG CCATTGGCGG GTGGGTGATT TCAGGCAGGA CACGCAGTGT CTGGGGACCC 3 00

TGGCTTTCTC ACTGGAAGAC GAT TGTTATG GTCCAGAGGG TGGTAACTCA GGTGTTCATG 3 60

TCTGATTCTG GATGTTCTCT GCAGCTGCTG GAGTCTCCTG ATTGGAGAGC AGCAAATGAC 420

TGTTCAATGA CAGTTCTAGT TGTACCTCTA GCACCCCCAC TCGCTCGAG 4 69

(2) INFORMATION FOR SEQ ID NO: 1316:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 262 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1316:

GAATTCGGCC TTCATGGCCT AATCTATGTG TGTCAACTTT CATAGAACCC TACACCAAAA 60
AAGGTGAATT TTATTTCGTG ATAAATTAAA AAGTAAAACA AAAGAGACAA AAATAGTAAC 120

528

WO 98/45437

PCT/US98/06956

CAGGGAAGCT TTCAAAAAAT ATATGTTCTT GTTCAAGACC AGCATGGCCA ACATGGCGAA 180
ATCCCATCTC TAATAAAAAT AGAAAAATTA GCCAGGCGTG GTGGTGGGCG CATGTAGTCC 240
CAGCTATCCA GCACCGCTCG AG 2 62

(2) INFORMATION FOR SEQ ID NO: 1317 •

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 17:

GAATTCGGCC TTCATGGCCT AAAGGAATGG TATTTTGGCA ACGCAGACAA AGAAAGGAGT 60

GGCCCGTATG GATTTCA TGA GATGCAAGAA TTGTGGACCA AAGGAATGTT AAATGCAAAA 12 0

ACCAGATGCT GGGCTCAAGG CATGGATGGA TGGCGAC CAC TTCAGTCCAT ACCCCAGCTC 180

CGAGTCATAT AAGGTAACCC AGACAACCAC CTACGAATTT AAAGCTCCTA TAAGTTGCCC 240

TTTCTG CATC CGAAGTGTGA TATTTGAAAG TTAAAAACGT TATCTTACAT ACATAGATCT 3 00

TAAAACGTAT CTTACACCAC AACCTACTCA CAGATGCAAA GGCAGTGGTC GTGGTCTTCC 360

ATTGCTTGGG GTCCTGGGGC CGGGTTTGAG GCTGAATGTC AGGGTTTCCT TTG C CATAAC 4 20

CTCATTCTGC ACCACGTGCT GTCAG CCAGG CAG CCAATGT GGACTTGGAG GCTGGCATCT 4 80

GCTGGGCACT GCTCGAG 4 97

(2) INFORMATION FOR SEQ ID NO: 1318:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 51 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1318:

GAATTCGGCC TTCATGGCCT AATCTGGATG TCTGTCCAAG GCCTGACTGC TGAACTCCTA 6 0

CTTTTCCTAC AAAACCCTAC CCACATGGCC CTTCCTGCGG GAAGAGATCT TGAGCCTCCC 120

TGGCTATTAA GACTCTGCTG TGCAGCCTTC TTTTACTGGA CTCAGGGCTA TCTTCCCCAG 180

ACTAGGGCCT TCTTGAGGAC AATCGTGGTG GCCCAGTGGT TGACGCTGTC TCCCCTGCAT 24 0

GTAGTTGGTC TTCCTGGTTG CTTCTTGCCC CTGTGGCTCC CTTGGGAGAC TGAAACTCAG 3 00

AGGACAGCTT CTGGTCTGCT GTTACATGGC TCCCACAGGG AGACTGGCCC CACCTGTGCC 36 0

CCACCCATCA CAGCTAGGGC CTGGGATGGG TCAGACACTG GAAGAGCCTC CCCCTAGGCC 420

ATGCATATGG ATCGTGCCCA CACGCCTCGA G 4 51

(2) INFORMATION FOR SEQ ID NO: 1319:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH; 4 77 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1319:

529

WO 98/45437

PCT/US98/06956

GAATTCGGCC TTCATGGCCT ACACTACGGT ACTCCCAGCA
TAAATAACAT GGCCATTTTT TAAAAAGGAC ACAGGAACTA
TTTGGAAAAT TCTAAATATG T CT AGAAAAA CTTTTCTTTC
TCTCCATGAC CCCCTCCCCG CGGACTGTAT CAGGTACAGC
CACATTAGGC ACACCAGTGG TAAGTTTACT TGTTGAGTTA
ATCAGAGAGG CAGCTCTGTG TTGAAGATGC TAGGTAGTGA
TTTGTTACCG TGGTAACCGG GGATGGACAT CATGACCTTT
CTTGGTAGTC TCTTCCCCTA ATTAACATCC TGTGAGAAAC

(2) INFORMATION FOR SEQ ID NO: 13 20:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 284 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA
(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1320:

GAATTCGGCC TTCATGGCCT AGACGGAGGC TGGAGATTCA CATGGGGCGA GGAGTTGCAG 60

ACCAGCCTGG GCAAAGCATG GTGAGGCCCC GTCTCTGCAG AAATGAGAAA ATGAG CTGG A 120

TGTAGTGGCA CCGACATGTG GTCCCAGCTG CTGGGAGGGC TGAGGTGGGA GGATTG CTTG 180

AGCCTAGGAG TTCAAGGCTG CGGTGAGTAG ATCGTGCCAC TGCGCTCCAT CCCTGGCAAC 24 0

AGAGCAAGAT CATTTCTCAA AAAGAAAAAA AAAGCCATCT CGAG 284

(2) INFORMATION FOR SEQ ID NO: 1321:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 254 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1321:

GAATTCGGCC TTCATGGCCT AGGGAAATGT GTGATTGGGA AAGAGGCAGC TTTTAAAAAT 60

GTGTCTGGCC TTTGACCACG CAATTTCACT TTCCAGTATT TATTCTAGGA AAATACTCAT 120

ACTATTGCAA AGTTTATATA TAAAGATAGT TATAACTGCA TTGTTTATCA TTTACAAAAA 180

GAAAACATCT GAAAG CCCAA CAAGACGGAA CTGGTTATTC CACATTGGCA CATTCATACA 24 0

AGGCAATG CT CGAG 254

(2) INFORMATION FOR SEQ ID NO: 1322:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 52 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1322:

GAATTCGGCC TTCATGGCCT AGGCACAGAA AAATTGGAAA GGATTGGTGG TCGTACATCT 60
TGCAGCTCAC TTAGTAGCTG CATGCATGTA GACCGGGTGG TGTTGATGCA GTGTTGACTT 120

TATCACCCTT AATGTAACTT 60

CATAACATTT TTTTTCAGAT 12 0

TGTTCCATTC TCCTTCCTAT 180

CTGTTGGAAA TCCAGCACCG 24 0

TCACCTTTTT TTTCCTTTTA 3 00

TGGAAAAGAC ATTAGGAAAA 3 60

TGTGATATGC ATGCTGTGGC 420

GTGAGAGATG ACT CGAG 4 77

530

WO 98/45437

PCT/US98/06956

GCTGGCATTG GGGTGGGTGG TAGCATGGTC AAGCTGGCTG AGTGATGGGA TATTGTCTCA 180

GAGGTTGGTG CAGGGAAACT CTGTGGGTGT GTCTAATGCA AG GAT AATGA CAATGTCCTG 24 0

TCTGCCTGGT CTTTGGGGGG TCAGGTGGAG ATGTCCTTTT GGAAAGGCAG CCATTCTCTT 3 00

TGAGTGTCCA GAGGGCATGG TGCAGGCACA TGGATTGAGT GGAGGACTCG AG 3 52

(2) INFORMATION FOR SEQ ID NO-.1323:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 440 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1323:

GAATTCGGCC TTCANGGCCT ACTGTGTGTA GAATTCTGTT TTCTCATGAT ATTGAAGACA 60

TTATT CCAGT ACTTTGACTG CTAGTATTGC TGTTGAAAAG TCTTAATTGC CCTTCCTTTG 120

TAAGTAATAA CCCTTTTATT TGGCTGTGTT AAGCCTTTTT TTTTCCTTCC CATTTAGTGT 180

TTTGCAGTTT TGTATAATGT ATTGAGGGCG TTATTTTTTT CATTCCATCA TTTTATTTTT 24 0

TGTAATCCCA CTTGGGATTC TTTGGGCTTC CTGGATCTGA GGATAATAAT AATGTCTTTG 3 00

AATAATTGTG GAAAATTCTT AACCATTATC TCTTTGAATA ATGCCTCTTA TTTTCTCCTT 36 0

CTATAACTCT AATTAGACAT ATAGTCTATT TTTCATGTTA CTTATGCCTT TTCATCCTTT 420

TTCGTCTCCA CATACTCGAG 44 0

(2) INFORMATION FOR SEQ ID NO: 1324:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 280 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1324:

GAATTCGGCC TTCATGGCCT AATTGAATTC TAG ACCTGC C TAAAATGCCC AGTTACCTGA 6 0

AATTGTATAA ATTCTTGCCA AAAGTGTTTG AACTTAATAC AAACTTCC CA TCTCTTACCT 120

CTTAG CACTG TGCTCATCTT GAGGGGACAT AGTCCCAATT TTGTATTTTA TATAATACTG 180

TTAATGAATA TGTGTAGACT TCATATGGTT GTGGGTAAGA GAATACTGCA TTCAGATAGA 240

AAAGATGCTA TATAG CTAAG TTGATCCGCG GATCCTCGAG 280

(2) INFORMATION FOR SEQ ID NO: 1325:

(i) . SEQUENCE CHARACTERISTICS:

(A) LENGTH: 281 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 25:

GTTTCCTTTT CTACTTACAA AGAAAATAAA TAGAAATAGA TTTTACATGC TTTATTTCTT 60

TGAGACAAGC CATTGTAAAT TGTTACTAGA CTAAGTAGTA GTATACCAGT CATTGACTGG 120

TCTTTTCAAC TCCACTCAAA TTTGTAAAAA GCAATTCCTC TTATACTATC ATCTTTTTTG 180

531

WO 98/45437

PCT/US98/06956

TTTTTTAAGG TTTTTGTTGT TGTTTGGTTT TTTGGCAAAA CATGATACAT TTCTCATGCT 24 0

TGATCTAAAG AGG CTTTACA TAAGAGACAG AGTCGCTCGA G 281

(2) INFORMATION FOR SEQ ID NO:1326:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 34 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 26:

GAATTCGGCC TTCATGGCCT ACTATCTTGA ATGTCCAACT CCAACTCCTA ATTATTTTAA 60

AAATCTATGC ACTTCTTTCA CTTGAATTTC TATGCCCTCA TAGACTTTAC AGGCACATGT 120

TCTATCACCA ATTAAGAGAA ATTTAACTTA CACATTTTAC AACTTATACA TGCAATTTGG 180

CTGAGCTTAT ACAG CACAGA TCAACATTAC AATCAATTTA CTGCCATGTT AAAAAAAAAA 24 0

TCAGTGAACA TTGTTCGGCT GACCTAATTT TTTGAAATAA GTTGG CCATC AGTGTAATTG 3 00

ATTGAGCTAT CTGTACAACC CCGAACCTAC CTAAG CAAAG GGCTCGAG 34 8

(2) INFORMATION FOR SEQ ID NO: 1327:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 68 0 base pairs

CB) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 1 3 2 7 :

GAATTCGGCC TTCATGGCCT ACACGG ACT T ACATCCTCAT TACTATTCTG CCTAG CAAAC 60

TCAAACTACG AACGCACTCA CAGTCGCATC ATAATCCTCT CT CAAGG ACT TCAAACTCTA 120

CTCCCACTAA TAG CTTTTTG ATGACTTCTA GCAAGCCTCG CTAACCTCGC CTTACCCCCC 180

ACTATTAACC TACTGGGAGA ACTCTCTGTG CTAGTAACCA CGTTCTCCTG ATCAAGTATC 24 0

ACTCTCCTAC TTACAGGACT CAACATACTA GTCACAGCCC TATACTCCCT CTACATATTT 300

ACCACTAACC CTCGAGACCA CTTCATATAA ATACTTATTT ATTTCCTATT TCCCCTGACT 360

AGAAATATAA GCTCCATGGT AGCAGAGATT CTGATTGCTG CCTACTCTAT CCCCAGCTCC 420

TATACTAGGC ACCATGAGTA CATGATCAGA AAATATTCAT GGAAAAAAAT ACATAAATGT 4 80

ATAACAATCT TCATTTGTGA GTAAGAAGAT GGGCTCTGGA ATCAGACTGC CTGGATTGAA 54 0

ATCCTAACTT CATCACTTAC TAGTCATGGG ATATTTTACC TCAGTTTCAC TTTTTGAAAA 600

TGAAGATAAT AATGTCTACC TTATAGTATT GTGAGGATTA AGTGAATTAA TGCACACAAA 660

ATTAGGCCAT GAAGGCCGAA 680

(2) INFORMATION FOR SEQ ID NO: 132 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 499 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 28:

532

WO 98/45437

PCT7US98/06956

GAATTCGCGG CCGCGTCGAC TGTCACTGAG CTTCTTGGCT CTCTTATATA TATTCTTTAT
TGTCATTTAC TTTGGTGGAC GAAGAGAAGG AGAGAGTTGG AATTGGGCCT GGGTCCTCAG
CACTAGATTG GCAAGACATA TTGGATATTT GGAACTCCTC CTTAAATTGA TGTTTGTGAA
TCCACCTGAG TTGCCAGAGC AGACTACTAA AGCTTTACCT GTGAGGTTTT TGTTTACAGA
TTACAATAGA CTGTCCAGTG TAGGTGGAGA AACTTCTCTG GCTGAAATGA TTGCAACCCT
CTCGGATGCT TGTGAAAGAG AGTTTGGCTT TTTGGCAACC AGGCTTTTTC GAGTATT CAA
GACTGAAGAT ACTCAGGGTA AAAAGAAATG GAAAAAAACA TGTTGTCTCC CATCTTTTGT
CATCTTCCTT TTTATCATTG GCTGCATTAT ATCTGGAATT ACTCTTCTGG CTATATTTAG
AGTTGACCCA AAGCTCGAG

60
120
180
240
300
360
420
480
499

(2) INFORMATION FOR SEQ ID NO: 132 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 200 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 132 9:

GAATTCGCGG CCGCGTCGAC CGCTGCCAAA TGCTTCACTC CTATCTACTC TCCCGATTCC 60

TTATACTTCT GAACCTCCTC AACAGAAATC TTGCTCTCTC CCTAAATCCT CAGTGCAACA 12 0

TACGTCCGCA AAAACTAAAT GATCCCTCCT CAGCCAGACA GAAAACTCTC AACATATCAA 180

CACTCCCAAG GCGTGGACAG 200

(2) INFORMATION FOR SEQ ID NO: 133 0:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 158 base pairs

<B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 30:

GAATTCGGCC AAAGAGGCCT ACAGTCTTTT TAGGCATGTT TTTTTTTTTT TTGGTGTGTG 60
TGATGACAGG AATATG C ATT TTATCTGTAG TGGTTTTAAA TCCTGTATTA AGCGTTGTTT 120
TCTTTTCAGA CTGCAAAATT CAAAATGGGG CTCTCGAG 158

(2) INFORMATION FOR SEQ ID NO: 1331:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 552 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1331:

GAATTCGCGG CCGCGTCGAC GATCATGAAG CGCTCGGTAG CCGTCTGGCT CTTGGTCGGG 60

CTCAGCCTCG GTGTCCCCCA GTTCGGCAAA GGTGATATTT GTGATCCCAA TCCATGTGAA 120

AATGGAGGTA TCTGTTTGCC AGGATTGGCT GATGGTTCCT TTTCCTGTGA GTGTCCAGAT 180

GGCTTCACAG ACCCCAACTG TTCTAGTGTT GTGGAGGTTG CATCAGATGA AGAAGAACCA 240

533

WO 98/45437

PCT/US98/06956

ACTTCAGCAG GTCCCTGCAC TCCTAATCCA TGCCATAATG GAGGAACCTG TGAAATAAGT 3 00

GAAGCATACC GAGGGGATAC ATTCATAGGC TATGTTTGTA AATGTCCCCG AGGATTTAAT 360

GGGATTCACT GTCAGCACAA CATAAATGAA TGCGAAGTTG AGCCTTGCAA AAATGGTGGA 4 20

ATATGTACAG AT CTTGTTG C TAACTATTCC TGTGAGTGCC CAGGCGAATT TATGGGAAGA 4 80

AATTGTCAAT ACAAATGCTC AGGCCCACTG GGAATTGAAG GTGGAATTAT ATCAAACCAG S4 0

CAAATCCTCG AG 552

(2) INFORMATION FOR SEQ ID NO : 1332 :

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 76 0 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 133 2:

GAATTCGCGG CCGCGTCGAC CTCAGAACTA TTTAAATTTA GTTAAATTAC TATTATATTT 60

TATAGTAAAT ATTGGTCCAC TTTATAGCTC AGAAC CTAAA AAGAGAATAT GTACCCAAAC 12 0

TTCTCTATGT TTACAACCAA CCCAGAGTTT AAGATTCTGA ATTGTGCTTT GTTTTGTTAA 180

AAATTTAACC AAGGGTCAGG CACAGAGGCT CATGCCTATA ATCCCAGCGC TTTGGGAGGC 24 0

CGAGGCGGGT GGATCACTTG AGTTCAGGAG TTCGGGACCA GCCTGGCCGG CATGGTGAAA 3 00

CCCCGTCTCT ACTAAAAATA CAAAAGTTAG CCGGGTGTGG TGGCATGTGC CTGTGGTCCC 3 60

AGCTGCTTGG GAGGCTGAGG CAGGATAATC NCTTGAACCC AGGAGGCAGA GGTTGCANTT 420

GCAGTGAGCC GGGATTGTGC CATTGTACTC CAGCCTAGGC AACAAGAGCG AAACTCTGTC 4 80

TTAAAAAAAA AAAAGAAAAA AAAATTAACC AAGGTTCTCC TTTCTCTAAA TCTAG CAATT 54 0

TGTTCTATTT TTCAGAAATA AACTTAATAA TTT TAATACA GATTTTAGCT TTGGCTTTTT 600

TCTTACTTTT TAGTTTGCAA ATTATTTTAT GGTATTCCTA CAAAGTAGAT ACAAATTTGC 660

ATTCAGAATG CACCTTTTGT TTTTCTGGGT TTTTTTGTTT GTTTGTTTGT TTTTTCAGAA 720

AACTCATGGA AAAGTACACT GTTCACCTCA GCATCTCGAG 76 0

(2) INFORMATION FOR SEQ ID NO: 133 3:

<i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 579 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1333:

GAATTCGGCC AAAGAGGCCT ANAACTGGGT AAGGAGCAAA AAAAGTGACA GAGGCCAGGC 60

GCGGTGGCTC ATGCCTACAA TCCCAGCACT CTGGCCAAAT ATTTGATTTT AAATTCCCAT 120

TGTTACTGAT TAAAAAAAAA AAAAATCTGG ACCAGTTAAC CTGGAGATTT AGAGGCTATA 180

GACACAATTT AACATCCATA CAGGCCTGTG AACTTCATGC AGAGAACAAA CAAACAAACA 24 0

AAAACTCTAA TTCAGAGTCT CTCATTTCAG CTTAGCCAAC ACATTTGGAG ACTTAGGGGC 300

CAGTTCTAGA AGCTGCTTTT ACCTCTAGAC TCGGAGGGGC AGGCCCTGTC AC CGAAGGGA 360

GGAAAACTCT TCTTGGCTGT CAGCCCGGAT TGAAGCCACT TCGCTTCCCC TGGCCCCAGC 42 0

TTTCCTGCAC TCTTTTCACC GTGTCTGACA CAGGGCAAAC CACCAACCAC TCAAATG AG C 4 80

AAACAATTCC AGAAAAAAGA ATCCGAGATA AAGAATAACC AACTAGGAGT CTTTCCATTG 54 0

TAG CCTAAAC CGTCGATTGA ATTCTAGACC TGCCTCGAG 579

(2) INFORMATION FOR SEQ ID NO: 1334:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 521 base pairs

534

WO 98/45437

PCT/US98/06956

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 34:

GAATTCGCGG CCGCGTCGAC CAACAAGGGC AAAGGCCTTG AGACACAAAC CAACTGTGTG 6 0

GGTGTAAAGG TAAGAAAGGC CAGTGAGGCC AG CATGATGA ACTGGGGGAG CATGGTGGCT 120

GATTTGGTCA GGAAGGGAAC AGAAACCAGA CCACTTGGGA TCTTCTAGCC AGAGTAAAGA 180

GACTGAGTTT ATTCCTATTG TAATGGGGAG CTATTCAGAG AGGTTAATCA TGGAAGTGAT 240

GTGACCTGAG CTACACTCTT AAAAGATGCC TCTGGCTGCT GTGTGGAGAA TGAACCATGG 3 00

GGGCAAAAGC AGAAACAAGA AGACCACTTA AGAGGCTCTT GCAATAATTT ATGTGAGAAG 36 0

AGTGATCATC TTGACTAGGG TGGTGGTGGT AGAGGAGGTG AGTGGTGGTC AGGACTGAGA 42 0

GGAGCCAACA GAATTTGCTG GCTTGCTTGG ATGTGGGTGA TGAGGCAAAC TGAGAATCCA 480

AGATGGCACC AAGGC TTATA CCCTGAGCAA CTGAACTCGA G 521

(2) INFORMATION FOR SEQ ID NO: 1335:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 775 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 35:

GAAATTCGCG GCCGCGTCGA CGCTCTTGAG TGAGAC CCAA CAAGCTGCTT TTCACCAAAT 6 0

TGCAATGGAG CCTTTCGAAA TCAATGTTCC AAAG CCCAAG AGGAGAAATG GGGTGAACTT 120

CTCCCTAGCT GTGGTGGTCA TCTACCTGAT CCTGCTCACC GCTGGCGCTG GGCTGCTGGT 180

GGTCCAAGTT CTGAATCTGC AGGCGCGGCT CCGGGTCCTG GAGATGTATT TCCTCAATGA 24 0

CACTCTGGCG GCTGAGGACA GCCCGTCCTT CTCCTTGCTG CAGTCAGCAC AC CCTGGAGA 3 00

ACACCTGGCT CAGGGTGCAT CGAGGCTGCA AGTCCTGCAG GCCCAACTCA CCTGGGTCCG 3 60

CGTCAGCCAT GAGCACTTGC TGCAGCGGGT AGACAACTTC ACT CAGAACC CAGGGATGTT 420

CAGAATCAAA GGTGAACAAG GCGCCCCAGG TCTTCAAGGT CACAAGGGGG CCATGGG CAT 4 80

GCCTGGTGCC CCTGGCCCGC CGGGACCACC TGCTGAGAAG GGAGC CAAGG GGGCTATGGG 540

ACGAGATGGA GCAACAGGCC CCTCGGGACC CCAAGGCCCA CCGGGAGTCA AGGGAGAGGC 600

GGGCCTCCAA GGACCCCAGG GTGCTCCAGG G AAG CAAGG A GCCACTGGCA CCCCAGGACC 66 0

CCAAGGAGAG AAGGG CAGCA AAGGCGATGG GGGTCTCATT GGCCCAAAAG GGGAAACTGG 72 0

AACTAAGGGA GAGAAAGGAG ACCTGGGTCT CCCAGGAAGC AAACAGAGAC TCGAG 775

(2) INFORMATION FOR SEQ ID NO: 133 6:

(i) . SEQUENCE CHARACTERISTICS:

(A) LENGTH: 155 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1336:

GTAGATTTAG ATGTACAGAT AGAGGTATGA TTTTTTTAAA AGGCACCTCA GTATGGGTAA 6 0

TGTTATCTTT CTTGTGTTTC AGTGCACACA CATACACACA CACCATAGAT GCAAAGTGTG 120
TAGAAAATGT ATTGAAGGAT ACCCAGGTAC TCGAG 155

535

WO 98/45437

PCT/US98/06956

(2) INFORMATION FOR SEQ ID NO: 1337:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1337:

GAATTCGCGG CCGCGTCGAC ATTCATGCAA ATAAATATAT TACTAAAATG CTACCTGTTT 60
CTTTTTCCTC TTTTTCTTCC AGTTTTAGTT TATGAGATTG GGTCTTGCTA TGCTGCCCAT 120
GCTAGGCATG AACTCGAG 13 8

(2) INFORMATION FOR SEQ ID NO: 133 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1338:

GAATTCGCGG CCGCGTCGAC CTAAACCGTC AATTCTTCCC ATCTTAGGTT TCTCTCCTCG 60

GAAGCCTTCT CTTTAGAATC GAACATTTTC TCTTCTGGCT TTGTTCGGAT GGTTTCTGGT 120

CTGTTTCTTT CTTGCTCCCT CGTGGCTTTC ACTTCTGTTT TCTTTCCCAG AATGACGGTC 180

CTCTCATTTG ACCGTGTGCT TTCCGAAGCA CCTGCTGCCA CCTTGTCTCG GCGATCCCGG 240

TTACTCGAG 249

(2) INFORMATION FOR SEQ ID NO: 1339:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 108 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 133 9:

GAATTCGCGG CCGCGTCGAC AAAACAACAC ATTTTAAAGA TTACGTGCTT CTTGGTACAG 6 0

GTTTGTGAAT GACAGTTTAT CGTCATGCTG TTAGTGTGCA TCCTCGAG 108

(2} INFORMATION FOR SEQ ID NO: 134 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 652 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

536

WO 98/45437

PCT7US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1340:

GAATTCGGCC
GTTTTTCATA
TAAGCCTTCT
TCCGGATTCC
TGCTCCAGAC
TAACATTAAA
AGTGGGAGAA
TGGGGATGAG
TGAGGCTGCC
TGCTGCTGCT
C ACT AAAG C C

AAAGAGGCCT
TTAATTGTTC
G GTAGTACC A
AAATCAGATA
TTCCCAGCTC
CATAAAGAAG
AAACCCTTGC
AACCTCTCAG
CAGGCTAAAG
G C AG AG CACT
ATTACACAGA

AATAGAAGGC ATTCCATATT TGTTCAATGA ATTAACAAAT
TGATTTTTAC CTCCTTAGGC CAGCCTTTAT TATTGCCATA
AGATGTATTA TGTTCCACAA TTAAGACAAA TTCCTCCATC
CCACCGTTGA AAGCTCCCAT TCAGGATCCA ATGATGCCAT
AGGTGCTAGG CACAAGAGAT GATGACCTCT CAGCCACTGT
GAATCTACAG TAAGAGGGTA GTGACTAAGG CATCCTTGCC
AGAATGAAAA TGCAGATGCC TCAGTTCAAG TGCTAATCAC
ACAAAAAACA GCAAGAGATT CACAGTACAA GGGCAG TGAC
AAAAAGAATC TTTGCAGAAA GATACTGCAG ATTCCAGTGC
CAGCTCAAGT AGGAGACCCA GAAATGAAGA ACTTGCCAGA
AAGAGGAGAT CCATAGGAAG AACGACCTCG AG

60
120
180
240
300
360
420
480
540
600
652

(2) INFORMATION FOR SEQ ID NO: 1341 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 817 base pairs

(B) TYPE: nucleic acid

(C) STRAND EDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1341:

GAATTCGGCC AAAGAGGCCT ACGTGCCATT TCTCTTCCAC TATGAGAGGA CCGATTGTAT 60

TGCACATTTG TCTGGCTTTC TGTAGCCTTC TGCTTTTCAG CGTTGCCACA CAATGTCTGG 120

CCTTCCCCAA AATAGAAAGG AGGAGGGAGA TAGCACATGT TCATG CGGAA AAAGGGCAGT 180

CCGATAAGAT GAACACCGAT GACCTAGAAA ATAGCTCTGT TAC CTCAAAG CAGACTCCCC 24 0

AACTGGTGGT CTCTGAAGAT CCAATGATGA TGTCAGCAGT AC CATCGG CA ACATCATTAA 3 00

ATAAAGCATT CTCGATTAAC AAAGAAACCC AGCCTGGACA AGCTGGGCTC ATGCAAACAG 360

AACGCCCTGG TGTTTCCACA CCTACTGAGT CAGGTGTNCC TCAG CTGAAG AAGTATTTGG 420

TTCCAGCCAG CCAGAGAGAA TATCTCNTGA AAGTGGANTT GCCAAGGCCA TGTTAACCAT 4 80

TGCTATCACT GCGACTCCTT CTCTGACTGT TGATGAAAAG GAGGAACTCC TTACAAGCAC 54 0

TAACTTTCAG CCCATTGTAG AAGAGATCAC AGAAACCACA AAAGGTTTTC TGAAGTATAT 600

GGATAATCAA TCATTTGCAA CTGAAAGTCA GGAAGGAGTT GGTTTGGGAC ATTCACCTTC 66 0

ATCCTATGTG AATACTAAGG AAATGCTAAC CACCAATCCA AAGACTGAGA AATTTGAAGC 72 0

AGACACAGAC CACAGGACAA CTTCTTTTCC TGGTGCTGAG TCCACAGCAG GCAGTGAGCC 7 80

TGGAAGCCTC ACCCCTGATA AGGAGAAGCA CCTCGAG 817

(2) INFORMATION FOR SEQ ID NO: 1342:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 76 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1342:

GAATTCGGCC AAAGAGGCCT AG CACCATGG ACAACCCACA GGCTCTGCCA CTCTTCCTAC 60

TCCTGGGGAT CCTCACCCTC AGAGCCTCTT CTGGACTTCA GCAAACCAAC TTCTCCTCTG 12 0

CCTTCTCTTC AGACT CAAAG AGCTCTTCCC AGGGGCTGGG TGTGGAAGTT CCCTCCATCA 180

AACCTCCCAG CTGGAAAGTT CCAGATCAGT TCCTGGATTC AAAAGCCTCT GCTGGAATCT 24 0

CTGATTCCAG CTGGTTTCCT GAGGCCCTGA GTTCCAACAT GTCTGGGTCC TTCTGGTCAA 3 00

ATGTTTCTGC TGAGGGCCAA GATTTGAGCC CGGTTTCCCC CTTCTCTGAA ACCCCTGGTT 36 0

537

WO 98/45437

PCT/US98/06956

CTGAAGTATT TCCTGATATT TCGGATCCTC AAGTTCCTGC CAAAGACCCC AAGCCTTCCT 4 20

TCACTGTTAA GACCCCAGCT TCAAACATTT CTACTCAAGT CTCCCATCTC CTCGAG 4 76

(2) INFORMATION FOR SEQ ID NO: 1343 :

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 726 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1343:

GAATTCGCGG CCGCGTCGAC CAGGAAATGA AGACATTGCC TGCCATGCTT GGAACTGGGA 60

AATTATTTTG GGTCTTCTTC TTAATCCCAT ATCTGGACAT CTGGAACATC CATGGGAAAG 120

AATCATGTGA TGTACAGCTT TATATAAAGA GACAATCTGA ACACTCCATC TTAGCAGGAG 180

ATCCCTTTGA ACTAGAATGC CCTGTGAAAT ACTGTG CTAA CAGGCCTCAT GTGACTTGGT 24 0

GCAAGCTCAA TGGAACAACA TGTGTAAAAC TTGAAGATAG ACAAACAAGT TGGAAGGAAG 3 00

AGAAGAACAT TTCATTTTTC ATTCTACATT TTGAACCAGT GCTTCCTAAT GACAATGGGN 360

TCATACCGCT GTTCTGCAAA TTTTCAGTCT AATCTCATTG AAAGCCACTC AACAACTCTT 420

TATGTGACAG GAAAGCAAAA TGAACTCTCT GACACAG CAG GAAGGGAAAT TAACCTGGTT 4 80

GATGCTCACC TTAAGAGTGA GCAAACAGAA GCAAGCACCA GGCAAAATTC CCAAGTACTG 54 0

CTATCAGAAA CTGGAATTTA TGATAATGAC CCTGACCTTT GTTTCAGGAT GCAGGAAGGG 60 0

TCTGAAGTTT ATTCTAATCC ATGCCTGGAA GAAAACAAAC CAGGCATTGT TTATGCTTCC 66 0

CTGAACCATT CTGTCATTGG ACTGAACTCA AG ACTGG CAA GAAATGTAAA AGAAGCACCA 720

CTCGAG 726

(2) INFORMATION FOR SEQ ID NO: 1344:

(i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 484 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1344:

GAATTCGGCC AAAGAGGCCT AGGGACAGCA ATCAAGTTCT AATGGTGCTC ACTTTTTAGG 60

TCACCTTCAT CACAGACTGC TCCAAAGGCA GAG CAATGTG GAACGAACCA GCACATTTAC 12 0

TTAAGATCAA AGTATGATAC ATCTCTTTGA GCGCCTCACT TCACAATAGG GATCCATTCA 180

TTGGCTTCCA GATGATG TTC ACAGTTCATG TAACACTGAT ACTGACTTTG TTCCTTATGT 24 0

TTAGACAGCT TCTCTGTCTA TACTTCTCAG AAACACCATC AACCAGAACA GAGCCACTTA 3 00

TTATCCACAA AAGTTGCATC AACCAGCTTA CCTTCTGGGA GGGATGGATG GTACCCAAAT 36 0

ACTCAAACTG AAT CCTATAG TGTGGAGCAA CCAAACAGAA AACAG T CCAA GGATTCAGGA 420

AATGGTAAAA ACATTTTAAA TCTAAATAGT AGTTATTTTC ATTTTGTTCT GCTCCCACCT 48 0

CGAG 4 84

(2) INFORMATION FOR SEQ ID NO:1345:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 125 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

538

WO 98/45437

PCT/US98/06956

(Xi) SEQUENCE DESCRIPTION : SEQ ID NO: 134 5:

GAATTCGCGG CCGCGTCGAC ATGAGTTTAA TTTTTTTTTT TTTTTTTACA CTT.TACATAG 60
AAATAGGATT ATGTGGGCTG GGCACAGGGA CTGACGCCTG TAATCCCAGC ACGTGGAGGC 12 0

TCGAG 12 5

(2) INFORMATION FOR SEQ ID NO: 1346:

(i) SEQUENCE CHARACTERISTICS;

(A) LENGTH: 760 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 134 6:

GAATTCGGCC AAAGAGGCCT AGACCCAGCG TACATACTGA ATGATCTCTA CATCTCAGAC 6 0

TACTGTGTGT GGATTCAGAA AGTCAAATCC AAAAAGTTGG CAG CTCTTGC AGAAGCCTTA 12 0

AAGGAAGTCT CCCTTACAAA GGCCCAGCTG GGGTTAGAAC TGGAAGAACT AGAAGCAGCA 18 0

GCACTGCTTG TCCAGGAGGA AGAAACTGCA TTAAAAGCAG CCCATTCAGT TTCTGGGCAG 24 0

CAGACACTTT GCTCCAGCTC TGAGGCAAGT GATTCGGAGG ACT CAG ACAG CAGCGTGTCA 3 00

TCTGGAAACG AAG ACT CAGG CTCAGATTCA GAACAAGATG AACTCAAAGA TAGTCCATCT 3 60

GAGACAGTCA GTTCTTTGCA AGGTCCCTTT CTTGAAGAAA GCAGTGCCTT TCTTATTGTT 420

GATGGTGGAG TACGCAGAAA CACAGCCATC CAGGAGTCTG ATGCCAGTCA GGGAAAGCCA 4 80

CTTGCCTCTT CCTGGCCTCT TGGAGTGTCT GGGCCTCTGA TAGAGGAGCT TGGGGAACAA 54 0

CTGAAGACTA CAGTTCAGGT TTCTGAACCC AAGGGCACCA CTG CTGTAAA CCGCAGCAAT 6 00

ATTCAGGAGA GAG ACGG CTG TCAGACACCA AATAATTGAC TCTTAGGTGG TTTTATT CAT 66 0

TGTTGAGAAA TATGGTAGAT TGGGTTTCAT TTACCGAATG AGAATTCTTC ATTTTCACTT 720

TGTAATTTTT CTTAGTATAT AGTCAGCCCA CACTCTCGAG 76 0

(2) INFORMATION FOR SEQ ID NO: 1347:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 52 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 134 7:

GAATTCGCGG CCGCGTCGAC CATTTCGAGA GTCCGTCTTG TAAATGTTTG GCACTTTGCT 60

ACTT TATTG C* TTCTTTCTGG CGACAGTTCC AGCACTCGCC GAGACCGGCG GAGAAAGGCA 120

GCTGAGCCCG GAGAAGAGCG AAATATGGGG ACCCGGGCTA AAAG CAGACG TCGTCCTTCC 18 0

CGCCCGCTAT TTCTATATTC AGGCAGTGGA TACATCAGGG AATAAATTCA CATCTTCTCC 24 0

AGGCGAAAAG GTCTTCCAGG TGAAAGTCTC AGCACCAGAG GAGCAATTCA CTAGAGTTGG 3 00

AGTCCAGGTT TTAGACCGAA AAGATGGGTC CTTCATAGTA AGATACCTCG AG 3 52

(2) INFORMATION FOR SEQ ID NO: 13 48:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH:. 251 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

539

WO 98/45437

PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 134 8:

GAATTCGCGG CCGCGTCGAC TCTAGGTTTT CTGATTTTGA TGGTAATATG GTATTCTGGG 6 0

AAATATCTGT CCAAATTAT C CTGATCTCTG AACTCCTGCT GTTGAGGTCA GTCACTTCAC 12 0

ACAATACCAT GATGACAGCT TTATCAAGCC AGATGCTTAG TCAGAGCTTT CCAAGACCCA 18 0

GCTTTGGTTT TAT CAG C AAA ATCCATCCTT CCCACCCCCC ATACACACGC CAGTTTGAGA 24 0

CTCCTCTCGA G 251

(2) INFORMATION FOR SEQ ID. NO: 134 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 30 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 134 9:

GAATTCGCGG CCGCGTCGAC CTAAACCGTC GATTGAATTC TGGACCTCCT GTGCAAGAAC 60

ATGAACCATC TGTGGTTCTT CCTTCTCCTG GTGGCAGCTC CCAGATGGGT CCTGTCCCAG 12 0

GTGCAGGTGC AGCAGTCGGG CCCTAGACAG GTGAAGCCTT CGGAGACCCT GTCCCTCAGT 18 0

TGTACTGTCT CTCTCGGCGC CATGAATGGT CATTACTGGA CCTGGATCCG GCAGACCCCG 24 0

GGAGGGAGAC TGGAGTGGAT TGGATCTGTC TATTATAATG GAAACAGAGT GTATCACCCC 30 0

TCCCTCGAG 309

(2) INFORMATION FOR SEQ ID NO: 13 50:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 553 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1350:

GAATTCGCGG CCGCGTCGAC AATTACTACC ATTGTTAAGT GTCTCTTTAA CTAAACTCAT 6 0

TGTTTAAAAG TTTTCTCCCT CTCTGTTTCT AAATCCAAAT TTCTGCTCTG GAATATATGT 12 0

TAGAAGAGAT ACATTTGTTG GAATGTTTGC ATTTCTTTTA TGAAATGCAG TATCTTTTGG 180

GGAATATTAT GTAAATGAAA TACCAATTAT TTTAAAAGAG CATTTTTGTG TGACATAGTG 24 0

CTTTCACAAA CTAAAACTGG AATTTCTTTC TTTAGTCTAT CTATATCTTT TGAAAATGTT 300

GACACAGCTA AG AAGAAG CT GCCTGTTCAT ATCTTAGATG GTCTGACCCT CAG CTACAAG 360

GTATATGCTG ATATTCCTTG TATGAACCGT GTTTTCTGCT AACATTAAAA CATGCAAGTA 420

ATTGGTTACT TTCTAATTTT GTTTTTGTTT CATAGGTCCC ATGGCCCGTG GACATTGTTA 4 80

TAAGTTTGGA ATGTCAAAAA AT TT ATAATC AAGTGTTTCT TCT CTTATTG CAAATAAAGT 54 0

GGGCATCCTC GAG 553

(2) INFORMATION FOR SEQ ID NO: 1351:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 209 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

540

WO 98/45437

PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1351:

GAATTCGCGG CCGCGTCGAC TTTATTTCAG TGGATTCTCT AGGATTTTCT ATATAAAAGA 6 0

TGTCATCTGA TAGAGTAGTT TACTTCTTCG TTTCCAACCT GAATGGCTTT TATTTCATCT 12 0

CTTTCCTAAC TGTCCTGGCT AGAACCTCCT TTACCACGTT GAATGGAAGT GGCAAGAATG 18 0

AACATCCTTG TCTTGTTTCT GATTTCGAG 20 9

(2) INFORMATION FOR SEQ ID NO: 1352:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 525 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:l352:

GAATTCGCGG CCGCGTCGAC AATGGCTTTT CTTCCTTCCT GGGTTTGTGT ACTAGTTGGT 6 0

TCCTTTTCTG CTTCCTTAGC AGGGACTTCC AATCTCTCAG AGACAGAGCC CCCTCTGTGG 12 0

AAGGAGAGTC CTGGTCAGCT CAGTGACTAC AGGGTGGAGA ACAGCATGTA CATTATTAAT 18 0

CCCTGGGTAT ACCTTGAGAG AATGGGGATG TATAAAATCA TATTGAATCA GACAGCCAGG 24 0

TATTTTGCAA AATTTGCAC C AGATAATGAA CAGAAT ATTT TATGGGGGTT GCCTCTGCAG 3 00

TATGGCTGGC AATATAGGAC AGGCAGATTA GCTGATCCAA CCCGAAGGAC AAACTGTGGC 360

TATGAATCTG GAGATCATAT GTGCATCTCT GTGGACAGTT GGTGGGCTGA TTTGAATTAT 420

TTTCTGTCTT CATTACCCTT TCTTGCTGCG GTTGATTCTG GTGTAATGGG GATATCATCA 480

GACCAAGTCA GGCTTTTGCC CCCACCCAAG AATGAGAGGC TCGAG 52 5

(2) INFORMATION FOR SEQ ID NO: 13 53:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 286 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1353:

GAATTCGGCC TTCATGGCCT AGGCTCCTAA AATAAATAAT CCACATAATT GTAAATGAAA 6 0

CACATCAAGG ATTTGAGTTA ATAGCCTCTG AGCAGGATTA ATATAGCCAT TAGACTGGAG 12 0

TATTTGTTAT CAAGAGGGCC AGAGAACCCA CCGCTAAAGC CGTAGGGTGG GAGGAACCCT 18 0

GGATTGCAGC TACATGGCTT ATGTAGGGAG TTTGTAACAG CCCCAAGCTG AAACCAGCTT 24 0

CTACACCCAT GACTGTTGAG TGATTGAATT CTAGACCTGC CTCGAG 286

(2) INFORMATION FOR SEQ ID NO:1354:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 572 base pairs

(B) TYPE i nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

541

WO 98/45437

PC17US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1354;

GAATTCGCGG CCGCGTCGAC CAACAAGAGC ACTGGCCAAG TCAGCTTCTT CTGAGAGAGT .60

CTCTAGAAGA CATGATGCTA CACTCAGCTT TGGGTCTCTG CCTCTTACTC GTCACAGTTT 12 0

CTTCCAACCT TGCCATTGCA ATAAAAAAGG AAAAGAGGCC TCCTCAGACA CTCTCAAGAG 180

GATGGGGAGA TGACATCACT TGGGTACAAA CTTATGAAGA AGGTCTCTTT TATGCTCAAA 24 0

AAAGTAAGAA GCCATTAATG G TTATTCAT C ACCTGGAGGA TTGTCAATAC TCTCAAGCAC 3 00

TAAAGAAAGT ATTTGCCCAA AATGAAGAAA TACAAGAAAT GGCTCAGAAT AAGTTCATCA 36 0

TGCTAAACCT TATGCATGAA ACCACTGATA AGAATTTATC ACCTGATGGG CAATATGTGC 420

CTAGAATCAT GTTTGTAGAC CCTTCTTTAA CAGT TAG AG C TGACATAGCT GGAAGATACT 4 80

CTAACAGATT GTACACATAT GAGCCTCGGG ATTTACCCCT ATTGATAGAA AACATGAAGA 54 0

AAGCATTAAG ACTTATTCAG TCAGAACTCG AG 572

(2) INFORMATION FOR SEQ ID NO: 13 55:

<i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 26 9 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 55:

GAATTCGCGG CCGCGTCGAC TGAAAAGTAG GTTTTTGAAG AGATATATTC GAAATATATT 6 0

TTTTCACTTG AAAAAAGTAA AAATTTTTTT CAAAAGCAAA TAATTCAACT CTAAAATTAT 12 0

AC TATTTCAA CATTCTCATT TATGTGAAAG CATGTGATAA ATTGTTGCTG CG TCAGAG AT 18 0

ATGAGAAACT CCTTTGCATT AGGTGGG CAT TATTCATAGA CTTCTACATG AAAGAGAAGA 24 0

GAAATAAAAG ATG CACCAGG ATTCTCGAG 26 9

(2) INFORMATION FOR SEQ ID NO: 13 56:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 713 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 56:

GAATTCGCGG CCGCGTCGAA CCCAGCAAAA TGGGGATCTC CACAGTCATC CTTGAAATGT 60

GTCTTTTATG GGGACAAGTT CTATCTACAG GTGGGTGGAT CCCAAGGACT ACAGACTACG 12 0

CTTCACTGAT TCCCTCGGAG GTGCCCTTGG ATACAACTGT AG CAGAAGGT TCTCCATTTC 180

CCTCGGAGTT GACCCTGGAG TCAACTGTAG CAGAAGGTTC TCCGATTTCC TTGGAGTCAA 240

CCCTGGAGTC AACTG TAG CA GAAGGTTCTC TGATTCCCTC AGAGTCAACC CTGGAGTCAA 3 00

CTGTAGCAGA AGGATCTGAT TCTGGTTTGG CCCTGAGGCT GGTGAATGGA GATGGCAGGT 36 0

GTCAGGGCCG AGTGGAGATC CTATACCGAG GCTCCTGGGG CACCGTGTGT GATGACAGCT 42 0

GGGACACCAA TGATGCCAAC GTGGTCTGTA GGCAGCTGGG TTGTGGCTGG GCCATGTCAG 4 80

CTCCAGGAAA TGCCTGGTTT GGCCAGGGCT CAGGACCCAT TGCCCTGGAT GATGTGCGCT 540

GCTCAGGACA CGAATCCTAC CTGTGGAGCT GCCCCCACAA TGGCTGGCTC TCCCATAACT 600

GTGGCCATGG TGAAGATGCT GGTGTTATCT GCTCAGCTGC CCAGCCTCAG TCAACACTCA 660

GGCCAGAAAG TTGGCCTGTC AGGATATCAC CACCTGTACC CACTAGACTC GAG 713

(2) INFORMATION FOR SEQ ID NO: 13 57:

(i) SEQUENCE CHARACTERISTICS:

542

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PCT/US98/06956

(A) LENGTH: 925 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 57:

GAATTCGGCC AAAGAGGCCT AG AATAATG C ATATACTGCC ATGTCAGATT CCTACTTACC 6 0

CAGTTACTAC AGTCCCTCCA TTGGCTTCTC CTATTCTTTG GGTGAAGCTG CTTGGTCTAC 12 0

GGGGGGTGAC ACAGCCATGC CCTACTTAAC TTCTTATGGA CAGCTGAGCA ACGGAGAGCC 180

CCACTTCCTA CCAGATGCAA TGTTTGGGCA ACCAGGAGCC CTAGGTAGCA CTCCATTTCT 24 0

TGGTCAGCAT GGTTTTAATT TCTTTCCCAG TGGGATTGAC TTCTCAGCAT GGGGAAATAA 3 00

CAGTTCTCAG GGACAGTCTA CTCAGAGCTC TGGATATAGT AGCAATTATG CTTATGCACC 36 0

TAGCTCCTTA GGTGGAGCCA TGATTGATGG ACAGTCAGCT TTTGCCAATG AGACCCTCAA 420

TAAGGCTCCT GGCATGAATA CTATAGACCA AGGGATGGCA NCACTGAAGT TGGGTAG CAC 4 80

AGAAGTTGCA AGCAATGTTC CAAAAGTTGT AGGTTCTGCT GTTGGTAGCG GGTCCATTAC 54 0

TAGTAACATC GTGGCTTCCA ATAGTTTGCC TCCAGCCACC ATTG CTCCTC CAAAACCAGC 6 00

ATCTTGGGCT GATATTGCTA GCAAGCCTGC AAAACAGCAA CCTAAACTGA AG AC CAAGAA 660

TGGCATTGCA GGGTCAAGTC TTCCGCCACC CCCGATAAAG CATAACATGG ATATTGGAAC 720

TTGGGATAAC AAGGGTCCCG TTGCAAAAGC CCCCTCACAG GCTTTGGTTC AGAATATAGG 780

TCAGCCAACC CAGGGGTCTC CTCAGCCTGT AGGTCAG CAG GCTAACAATA GCCCACCAGT 84 0

GGCTCAGGCA TCAGTAGGGC AACAGACACA GCCATTGCCT CCACCTCCAC CACAGCCTGC 900

CCAGCTTTCA GTCCAGCAAC TCGAG 925

(2) INFORMATION FOR SEQ ID NO: 1358:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 172 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1358:

GAATTCGCGG CCGCGTCGAC AAATAAACCC AGCAACTTCA TTCATTTGCC TTATGTTTAT 60
TGAGGGCCTG CTAGTGCTGG GCACTGTTCT AGGCCCTGGG AATTTATTAG TGAGCAAAAC 120
AG CAAAAT CT CTGTCCTCAT GGAGCTCACA ATATAGTAGG G AACG ACT CG AG 172

(2) INFORMATION FOR SEQ ID NO: 13 59:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 770 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO -.13 59:

GAATTCGGCC AAAGAGGCCT AAGTCAGTGA GGTGGAGTCC GTTTTTGAGG TCACGCGGCT 60

AGTAATTGGA GCCTGGTTTA GAACCAAGTC AGTCTCATTC CAGAATC CAG AAC CAGTGAT 120

TTGTAACTGA TGCACTTGTC TCCAAAGGGA TCCAGCACTG GGTTTTCTCA TTTTTAATGC 180

ATCCATTCCT TAAAGCCTCT GTTCACAGTC ACAAGGTGTA CTTTTTAAAG GAACACAGCA 24 0

CACAAATGTG ACCGCTAGTG GACAGCAGTG GCAGCCCAGT TGGATGG CAG AGCCTGGCAT 3 00

543

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PCT/US98/06956

GCCGACTGGG ACAGAAGCCC CAGCACACGG TGTGATGATG GCGTCTCCAG GCTGACCTCC 36 0

ATGGCCTCAG GAATCAAAGT CCTCGGTCTC TTTCACGCGG GGTTCAGAAA GAAAACTCGG 4 20

CTATCTTACA TCTCCTCTCC CCTGTTTATT TGACTAAAGT GAAGTTCATG TGGCTTGAGC 4 80

CTCGTTTCCT GGGGAAATCA GCCTGGCTTA GGATTCCATT GTCTTCTGGG ACTGGGAAGA 54 0

TGTGGAAGGC TGACCTCACG CCCAGCTGAA GGTCACCTTC CCAGACTCTG AGCTCGGCTG 600

CCTTCTGCAT CGCCACGGCT GGAGGGCCTG GCCCAGGCCG TGGCTGCATG CTGGCTTTCC 6 60

ACTGTCTCGG TGTCCCTGCT GCCTGTCAGT AATGTGCCCA GCACCTTCTG GTGTCATGTC 720

CCCTCTTGTT TGTGATTCTT TTCCTGAGCT AGTCCATTTT CTACCTCGAG 77 0

(2) INFORMATION FOR SEQ ID NO: 13 60:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 505 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 13 60:

GAATTCGGCC AAAGAGGCCT ACTCAGTGGA AACCTTTAAA CCCTAAAATC CAGGAAAAGA 60

AAATAAATAC ATTAT CATGG ACCTGAGGGA TTTTTACCTG TTGGCTGCTC TGATTGCCTG 12 0

TTTAAGGCTG GATTCCGCAA TAGCTCAAGA ACTTATTTAC ACTATTAGAG AGGAATTGCC 18 0

TGAAAATGTG CCCATAGGAA ACATACCAAA GGATCTGAAC ATTTCTCACA TCAATGCTGC 24 0

CACAGGGACC AGCGCCAGCC TTGTCTACAG ACTGGTTTCT AAAGCTGGGG ATGCCCCTTT 3 00

GGTGAAAGTA TCCAG CAGCA CTGGGGAAAT TTTCACAACC TCCAACAGAA TAGACAGAGA 36 0

AAAACT CTGT GCTGGCGCCT CATATGCTGA GGAGAATGAG TGTTTCTTTG AACTTGAGGT 420

GGTGATCCTC CCCAATGATT TCTTCAGGCT GATCAAAATA AAAATAATTG TCAAGGATAC 4 80

CAATGATAAT GCCCCCAATC TCGAG 505

(2) INFORMATION FOR SEQ ID NO: 1361:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 553 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1361:

GAATTCGGCC AAAGAGGCCT AAATTTGTTC TCTCCAAACC AG AAGAC CTT AGGTACAGAT 60

GACCCCAGGG AGCTGGGACA GCAGGACAGA NAGGGGAAGG GACAGGTCCA TATATAGGTG 12 0

TGTCATTGCA GCCACTGCAA TGAACATAAC ATGCAAGAAA TGTACAGAAT GTGGTCCAGA 18 0

ATTGCCCACT GGTGTCCTGT GCCCTGGTGG ACCCCACAGA GGACTGCCCC AGGCTTTCAC 24 0

TTTCCTTCCC CATGGATTGA GCAAGCTCCC AGGGCAGGAT GGGTGGCCAG GAGGGGCAGA 3 00

ACGCTGGCGG GGACGGGGAA GCCAAGTGCT CACAGGACCA TCCACCACAG CTGCAGCCAC 3 60

ACTGCAAGAC GGCGGGGATG GGACACACGG TCTAGTTCTT AGTTCTGCCT CCTACAGGCA 42 0

GCCCCTGCTG TCACTCCAGA ACTAATTCTC TGTGTGCCAC TCACTCGCGT GTGTGACACA 4 80

CAACAGATAC ACATACATAG ACACATACGT ACATCTCCTC CCCCAATCTC ACCCTCTCAC 540

CACGCCCCTC GAG 553

(2) INFORMATION FOR SEQ ID N0:1362:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 855 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

544

WO 98/45437

PCT7US98/06956

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1362:

GAATTCGGCC AAAGAAGCCT
CACCATCTCA GCAGCAGCCA
TGCCCCACAC TACACCTGAG
TCCCTATAGG CTTGAACTCA
CACAGTCCAG ACTAAGGAAG
ATCAAAACTC CAGCAAACAT
TTGTNCCCTA TGACTTTATG
GAGATGGCTG GCCACGTGCC
AATTTCGTCC CTGGTGAGCC
TACGTCACTC CTGGCAGTGT
CACCTCAGGG ACAGGAACAG
AG TG CCTGGT CATCCAT^CG
AGCACTTCAG CCAGAAATAG
ACCTCTCTGG CTCATGAGCT
TCCCGCCACC TCGAG

AGTCAACTTG ATCCAAACCT GTTGGTGAAG CAGCAGACTC
CTCCATCAGC CAGCCATGAA GTCTTTCCTT GACAATGTCA
CTG CAAAAAG GGCCATCACC AATAAATGCT TTCAGCAACT
AACTTGAATG T AAATATG G A TATGAACAGT ATTAAAGAGC
TGGACGACAG TGGACAG CAT TTCTGTGAAC ACATCTTTGG
GGTGCTATTT CAAGTGGTTT CAGGCTGGAA GAGTCTCCAT
AACAGCAGTA CTTCACCAGC CAGTCCTCCA GGTTCAATAG
AAATCG CCTA ACGGCTCTAG CAGTGTTAAT TGGCCACCAG
ATGGAAAGGT TATCCAAACA TTGACCCTGA AACTGACCCT
CATAAACAAT CTTTCAATTA ATACTGTGCG GGAAGTTGAC
TGGGTCATCC TCATCCTTGA ACACCACGCT GCCTTCAACT
TGCCTCCAAC TACAACGTTC CCCTCAGCAG TACAG CACAA
TGATTCCAAA TTGACATGGT CTCCTGGTTC AGTTACAAAC
GTGGAAGGTC CCTTTGCCAC CTAAAAACAT CACTGCTCCG

60
120
180
240
300
360
420
480
540
600
660
720
780
840
855

(2) INFORMATION FOR SEQ ID NO: 1363:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 64 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1363:

GAATTCGGCC AAAGAGGCCT ACAAAAAGTA CATAGTAAGA CTAAGATACC AAGTTGTATA 60

CTAATATTTT TCAGGCCTTG GGCCTCAAAT ATATATATTT ATATATAATA CTCCAGTGTG 12 0

AACAGCAATT CGATGAAATG TAAAATGTAT CTTTTTTTTT TTAAAT CACA CACAAGTATT 160

CATAACCACA GGGTTCACCA GAAAT CTAAA GCAAGGAGAC ACTCACTCAT ATAGAAATGG 24 0

AGTTACTCTT CCACAGATCG TTCTGATCAA AGGTTTTGGA ACAGAAATGA ATTAATGATT 300

TTTTTGTATA ATATCCAACA TGTCCACTAT CAAATACATT TAG TATG AAA AAACAGATGA 360

AGAAAAGGAA CATACATTAG GACAAAGTAT CTGGTTAAAA TGCTGTTCAT TTAAATAAAG 4 20

CCCACTCTCC TTACTTTAGA GCTCCTTGGT GAAATGGAGG TGAGTTTGAT GGAGTGCAGT 4 80

TGATGACCAC TGAAAAACAC GAGCCCTTTC AACAATGTTG CAACACTGTT AGTTTTTGGT 54 0

TTAAACACAC ACACACACTC ACAAATGCTA AGTGTACACT ACCAAATTCT GCGGTCAGCT 6 00

TTTCCAAGAA CTACTGGGGA AAGTTTCAAT GCTGCAAATC CTCGAG 64 6

(2) INFORMATION FOR SEQ ID NO:1364:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 502 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1364:

GAATTCGGCC TTCATGGCCT AATGGCTTAG CTGAAGGAAA TGCTCCAGAA ATTGGACTGT 6 0

545

GTAAACCATC AG TACAATAA TACGCTGTGT ATGTATGTGT ATATAAAATG AGAATTATGG
CAT AAT TGG A GCATTTGCAT TAATCAACAA ACTCACATTG AGACAAAACT TAGTTTTACA
GCTGTCTTGA TTAAAGCCAA GTGTTCCATG TTGCTGTGAA GAATAGCCTC TTTCAAATAC
TTTGGAAAGT AGTTACTTGG AAACTTGTAA AGGTATTACA TTTTTATATT TAAACACCTA
TAGAGATCTT CAATTCCTTG AGTCTGAGCT TGTGGGTGGA ATTCTAAATT TGTATCATAA
TCTGTCTTTT GTGAAACATT TTGAAAATAT G T AT ATATAA TATTGTATAT GCAAATTGTG
TTGTTTCACT TGTAAAGGGA AAAGGCTTAT TTTTCTTTAT ATTTCTGATA ACTTGTTTTG
CATATGACCG GCACTTCTCG AG

(2) INFORMATION FOR SEQ ID NO: 1365:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 197 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1365:

GAATTCGGCC TTCATGGCCT ACAGAAGTAC GGGAAGGCGA AGAAAAGAAT AGAGAAGATA
GGGAAATTAG AAGATAAAAA CATACTTTTA GAAGAAAAAA GATAAATTTA AACCTGAAAA
GTAGGAAGCA GAAGAAAAAA GACAAGCTAG GAAACAAAAA GCTAAGGGCA TCGATTGAAT
TCTAGACCTG CCTCGAG

(2) INFORMATION FOR SEQ ID NO: 136 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 314 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D ) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1366:

GAATTCGGCC TTCATGGCCT AGGCCTGGGG TGGGACATTT TGTTTGTGAG AAGCCTGGAC
AAGAGGACGA GGTGCACACC ATGTCAGTCA CGGATTTGTG AACTCACAGG AGAGGGTTGG
ATAGGGCGTG TGAACGTGAG CCCGCGGTGT AGACGATGTG AAGCTGTGGT AACGGGTGGG
CTTGTGATGG CACCCGCTGC TCGCAGGAGA GGGTTGGATA GGGCATGTGA ACGTGAGCCT
GCAATGTAGA CG ATG CGAAG TCGTGGTAAC GGGTGGGCTT GTGACGG CAC CCGCTGCTTG
CAGCCTAACT CGAG

(2) INFORMATION FOR SEQ ID NO: 1367:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1367:

GAATTCGGCC TTCATGGCCT ACTGGTCCCA TTTTTCTATT GCAGTGGTCA TCATTTTTAT
TGATGTATAA TAATATTGTA TCATAAATCT TCATAATATG TGCTTCCAAA GTTTTTTCTA

546

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PCT/US98/06956

ATTTTTCACT AACCTTTGAT TTGGTATTTA ATTTTTAGTT GTCAGAAGTT TTTAATATTT 180
GTATCATCAA AGCTATCAGG TTATTAAAAT TGACTTCTCA TTTAGACATA CTTAGGCCAT 24 0

GAAGGT CG AG 2 50

(2) INFORMATION FOR SEQ ID NO: 1368;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 261 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 68:

GAATTCGGCC TTCATGGCCT AG TG AG AG C A CCACACAAAG GACAGGAAAA ACACCAGCAA

TACATCAGCT TTACACAGCA GGCAAGTTTC CTGCTCTCTA CAAGTACAGA TGGAACTTGT

CTTGTGAATT AACATCCTGA CTACTTTTGT TG AT CATCAC ATTTTTTCCT CATGAGAGAA

ATAATAGTGT TTTATAGGCT CCTGAGAATA GGTTTACTAA AGTCATCGAG ATCTGGGTTC

AAATGACACT TCATGCTCGA G

(2) INFORMATION FOR SEQ ID NO: 136 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 408 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1369:

GAATTCGGCC TTCATGGCCT AGTTTTTGTT TGTTTGTTTG TTTGTTTTTT GGCAAGAACA
GTTAGGAACC AG ATCACAG T GAGGTATAGA GTGAATGAGA GTTGAGAATG TAAAGACAAT
GGATATAGAT CACTATTTCA GGAAGCTGTT TGTGAGAGGG AGGAGAAAAA TAAAACAGTT
ACTGAGCAAT AGGGTGGTTG GTAAGGGGGA GGGATTTTTT TCTGAAAGAT GGGAGAAATT
TTAACATACT TAAATTTGAT GGGATAAGCC ATGCACTTAT AGGCATTCAG TCAATATATA
TTTCACAAAT GAATGAAGAT AAATTAGGGA GAGG TTAATT GGAGATTTTA GGAGAGAGGG
AATAATTGAT CATGTAAAGT CATTGATAAG GTGGG AG CAG AACTCGAG

(2) INFORMATION FOR SEQ ID NO: 1370:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 369 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 70:

GAATTCGGCC TTCATGGCCT ACT CGAT T AC AGGTCTCCCG CCTGCCATGC AG AAAGT CAT 6 0

GTATAAGGGA CTCGTCCCCG AGGATAAAAC ATTGAGAGAA ATAAAAGTGA CCAGTGGGGC 120

CAAGATCATG GTGGTTGGCT CCACCATCAA TGATGTTTTA GCAGTAAACA CACCCAAAGA 180

TGCTGCGCAG CAGGATGCAA AGGCCGAAGA GAACAAGAAG GAGCCTCTCT G CAGG CAG AA 24 0

ACAACACAGG AAAGTGTTGG ATAAAGGAAA ACCTGAAGAT GTGATG CCAT CTGTTAAGGG 3 00

547

60
120
180
240
261

60
120
180
240
300
360
408

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GGCCCAGGAG CGCCTGCCAA CGGTACCGCT GTCCGGCATG TACAATAAAT CTGGAGGAAA 36 0

AGTCTCGAG 3 6 9

(2) INFORMATION FOR SEQ ID NO: 13 71:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 443 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 71:

GAATTCGGCC AAAGAGGCCT ATTTTTTTTT TTTTTAACTG ATAGATGGTG CAGCATGTCT 6 0

ACATGGTTGT TTGTTGCTAA ACTTTATATA ATGTGTGGTT TCAATTCAGC TTGAAAAATA 120

ATCTCACTAC ATGTAGCAGT ACATTATATG TACATTATAT GTAATGTTAG TATTTCTGCT 180

TTGAATCCTT GATATTGCAA TGGAATTCCT ACTTTATTAA ATGTATTTGA TATGCTAGTT 24 0

ATTGTGTGCG ATTTAAACTT TTTTTGCTTT CTCCCTNTTT TTGGTTGTGC GCTTTCTTTT 3 00

ACAACAAGCC TCTAGAAACA GATAGTTTCT GAGAATTACT GAG CTATGTT TGTAATGCAG 360

ATGTACTTAG GGAGTATGTA AAATAATCAT TTTAACAAAA GAAATAGATA TTTAAAATTT 4 20

AATACTAACT ATGGGATCTC GAG 443

(2) INFORMATION FOR SEQ ID NO: 13 72:

(i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 770 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1372:

GAATTCGGCC AAAGAGGCCT ACTTCCGGCT GGAGCTGCTG GGCGCGGGAC CTGGGGCGGT 60

TAATTTGGAG TGG CCCCTGG AGTCAGTTTC CTACACCATC CGAGGCCCCA CCCAGCACGA 12 0

GCTACAGCCT CCACCAGGAG GGCCTGGAAC CCTCAGCCTG CACTTCCTCA ACCCTCAGGA 180

AGCTCAGCGG TGGGCAGTCC TAGTCCGAGG TGCCACCGTG GAAGGACAGA ATGGCAGCAA 24 0

GAGCAACTCA CCACCAGCCT TGGGCCCAGA AGCATGCCCT GTCTCCCTGC CCAGTCCCCC 3 00

GGAAGCCTCC ACACTCAAGG GCCCTCCACC TGAGGCAGAT CTTCCTAGGA GCCCTGGAAA 36 0

CTTGACGGAG AGAGAAGAGC TGGCAGGGAG CCTGGCCCGG GCTATTGCAG GTGGAGACGA 420

GAAGGGGGCA GCCCAAGTGG CAGCCGTCCT GGCCCAGCAT CGTGTGGCCC TGAGTGTTCA 4 80

GCTTCAGGAG GCCTGCTTCC CACCTGGCCC CATCAGGCTG CAGGTCACAC TTGAAGACGC 54 0

TGCCTCTGCC GCATCCGCCG CGTCCTCTGC ACACGTTGCC CTGCAGGTCC ACCCCCACTG 600

CACTGTTGCA GCTCTCCAGG AGCAGGTGTT CTCAGAGCTC GGTTTCCCGC CAGCCGTGCA 66 0

ACGCTGGGTC ATCGGACGGT GCCTGTGTGT GCCTGAGCGC AGCCTTGCCT CTTACGGGGT 720

TCGGCAGGAT GGGGACCCTG CTTTCCTCTA CTTGCTGTCA GCTCCTCGAG 770

(2) INFORMATION FOR SEQ ID NO: 13 73:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 597 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

548

WO 98/45437

PCT/US98/06956

(xi) SEQUENCE DESCRIPTION; SEQ ID NO : 1373 : .

GAATTCGGCC AAAGAGGCCT
TCATGCTCCT GTGTTGGATG
AACTTTTACC ATTATGTAAT
TGTTTTGTCT AAAATTAGAA
AAATTTTTCT TCATTCCCTT
CTTGAACACT GTACTACTGG
ATTGGGCATT CAAGGCTAGT
TTGTTTATTA TGCTGACTTG
AAGTGTGTTT TTTTAGTAGC
TTGCAAGGAT TTTCTGAATN

AGTCTCTTTG
CATATACATT
GCCCTTGTTT
TTTCAGCCTC
ATTTTTAGCC
TTCTTGCTTT
GTTGATATGT
TTTGTGTGGT
AATATTTTCT
NT CNG AATTT

AAGATCTCTA GGAACTTGCT TTATGAATCT
TAGGATAGTT AGGTGTTCTT TTTGAATTGA
GTCTTTTAAA ATTTTTGTTG GTTTAATATC
TGCTTTTTTT CTGTTTTCCA TTTGCTTAAT
TATGGGTGTC ATTGGATGTG AGATTCATCT
TTTACTCAGC TTGTCACTCT GTGTCTTTCA
GTGAATTTGT TTCTGTCATC ATGTTATTAG
TTCNTTATAG TGTTACTGGT CTGTGCACTT
TTTCATATGT AGTGCTTTAT GCGAGGTATT
TTATGTGGGC TAAACTAGGG GCTCGAG

60
120
180
240
300
360
420
480
540
597

(2) INFORMATION FOR SEQ ID NO: 1374:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 59 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1374:

GAATTCGGCC AAAGAGGCCT AGCCTCCCAG TGTGAGCCAC CGCACCCAGC CTGGATTGTT 60

GAATTCAATG CTTGGGTCAC CTCCAGATTC ATTTT CACAG TCTTTCATGT TTTGGTCATA 120

TGACATTGTA TTTTGCTGCC ATATGACTGA TCTTTTTTTG TTAAATGTGA GATACTTGTT 180

AAAAAATGTT TAGCAATGAA TTGAGGCCTA GTAGCATGTT ATCTTGCTGC AGAAGAGATG 24 0

GGAG TCTACT TCTGGGGGAT GGTCAGGGGT CCTCCATACA GGCTGCAATT GAAGTCGTCG 300

GTGCAGGCTC AGTCC CTACA AAGGCCAGGG TATTTCCTGT CCACCTTTAT TCTGATGCAT 3 60

GACTCTTCTG GGTCTCAACC AGAGCCAGTG GACTTCAGTA TGGGTCGCTT TCATTGGCAG 42 0

ACCCTCAATC CACTTGTTTT CCATCTAATC CCACTCGAG 459

(2) INFORMATION FOR SEQ ID NO: 1375:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 531 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 75:

GAATTCGGCC AAAGAGGCCT AATGGATCTC ATGTG CAAG A AAATGAAGCA CCTGTGGTTC 60

TTCCTCCTGC TGGTGGCGGC TCCCAGATGG GTCCTGTCCC AGCTGCAGCT GCGGGAGTCG 120

GGCCCAGGAC TGGTGAAGCC TTCGGAGACC CTGTCCCTCA CCTGCTCTGT CTCTGGTGGC 180

TCCATCAGCA GCAATAGTTA CTCCTGGGGC TGGATCCGCC AGCCCCCAGG GAAGGGGCTG 240

GAATGCATTG GGAG CATCTC TTACAGTGGG AGCACCTACC TCACCCCGTC CCTCAAGAGT 300

CGAGTCACCG TTTCCGTAGA CCCGTCCAAG AACCAGTTAT CCCTGAGGCT GAG CTCTGTG 360

ACCGCCGCAG ACACGGCTGT GTATTATTGT GCGGGGGGGT CTCCGGGCGA TTATTC CTAT 420

GAGAATAGTG ATTACCCCGA CCCCCCGTAC TATTTAGACT CCTGGGGCCG GGGAACCCTG 4 80

GTCACCGTCT CCTCAGCTTC CACCAAGGGC CCATCCGTCT TCCCCCTCGA G 531

(2) INFORMATION FOR SEQ ID NO: 1376:

(i) SEQUENCE CHARACTERISTICS:

549

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PCT/US98/06956

(A) LENGTH: 661 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1376:

GAATTCGGCC AAAGAGGCCT AATGACTCAG AAGAAAGAAG TTACTTTACC ATTTTTGTTT 60

ACACCATTTA AACTGCTTTC TGATTC CAAA CAGTTCAACA TTTTAAGAAA AG CAAGATCT 12 0

TATATAAAAC ACAGAAAGTT TGATGAAGTG GTCTCCCTTT GCAAGGAGCT AATTCATCTT 180

GCATTGAAAG GATTGTCCTA TTATCACACA TATGACAGAT TCTTTTTGGG CGTCAATGTT 240

GTTATTGGTT TTGTGGGATG GATATCTTAT GCCTCTTTGT TGATCATCAA GTCTCATTCC 3 00

AACCTTATAA AAGG TGTTAG TAAAGAAGTG AAGAAAC CAA GCCATCTCCT GCCTTGTAGT 360

TTTGTAGCTA TTGGCATTTT AGTAG CATTT TTTCTGCTGA TTCAAGCCTG TCCCTGGACA 420

TATTATGTAT ATGGTTTGTT GCCACTGCCA ATATGGTATG CGGTTCTAAG AGAATTTCAA 4 80

GTTATTCAGG ACCTTGTTGT ATCAGTGTTG ACCTATCCTC TGAG CCATTT TGTTGGGTAC 54 0

CTGTTAGCCT TTACCCTGGG AATTGAAGTA TT AG TTCTCA GTTTTTTCTA CCGCTATATG 600

CTTACCGCTG GACTTACTGC CTTTGCAGCT TGGCCATTTC TCACTCGGCT GTGGACTCGA 660

G 661

(2) INFORMATION FOR SEQ ID NO: 13 77:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 117 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ii} MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1377:

GAATTCGCGG CCGCGTCGAC AAAAAAGGTA AAGATGTTGC TGTATGCAAA ATGGACCCAA 60
GTTATGTTTA TTCAAGTTGC CTGTAGAAAC TTAGTGCTCT ATAGC CACAA ACTCGAG 117

(2) INFORMATION FOR SEQ ID NO; 137 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 118 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1378:

GAATTCGCGG CCGCGTCGAC CTTAAATTTA AAACTGGCCT GGTTTGCCTT TTTTAT CAAG 6 0

AGAGCTTAAC AGATAAAAAA TGAAATTAGT CTATTTTCTA CTTGCCAGCA GTCTCGAG 118

(2) INFORMATION FOR SEQ ID NO: 13 79:

(x) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 229 base pairs

(B) TYPE: nucleic acid

. (C) STRANDEDNESS: double
(D) TOPOLOGY: linear

550

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<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1379:

GAATTCGCGG CCGCGTCGAC ATTTTATATA ATATTTTAAA TAAGTTTGTG TACAAAACAA

AGATTTGACT G CATTTTG AT TGTGACCCCG TTGCATGAAG TCAGGTGTGG AGTTTTCCAC

TTGTGGTATC ATGTTGCTGC TGCTCAAGAA GTTTCTGATT TTGGAACATT TTGGATTTTG
GATTTTCACA TTGGGGATAC CTAATGTGAG AGAGACTAGG CCACTCGAG

60
120
180
229

(2) INFORMATION FOR SEQ ID NO: 1380:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 14 0 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1380:

GAATTCGCGG CCGCGTCGAC GTTGGGGACA TGGTGGGTCT GAGAAAAGTG TTGCCCGCAA 60
CTTTCTATCT GGCATTCCCT G CGGAGG AAA TAGAATGCGC GCTCTCCGAC AGCATTTCCT 120
GTAACATCCG CGAACTCGAG 140

(2) INFORMATION FOR SEQ ID NO: 1381:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 99 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 81:

GAATTCGCGG CCGCGTCGAC TCT CAGAAGA GGTTTGTTTA ACTT CTATAA ATACAACCAC 6 0

TTCATGCGTT GGCATCTCCT TGAGAAAAGG CTTCTCGAG 99

(2) INFORMATION FOR SEQ ID NO: 13 82:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 442 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(XX > SEQUENCE DESCRIPTION: SEQ ID NO: 13 82:

GAATTCGGCC AAAGAGGCCT AGTTTAAGTG CTGTGGAGTA GTATATTTCA CTGACTGGTT 60

GGAAATGACA GAGATGGACT GGCCCCCAGA TTCCTGCTGT GTTAGAGAAT TCCCAGGATG 120

TTCCAAACAG GCCCACCAGG AAGAT CTCAG TGACCTTTAT CAAGAGGGTT GTGGGAAGAA 180

AATGTATTCC TTTTTGAGAG GAACCAAACA ACTG CAGGTG CTGAGGTTTC TGGGAATCTC 240

CATTGGGGTG AC ACAAAT C C TGGCCATGAT TCTCACCATT ACTCTGCTCT GGGCTCTGTA 300

TTATGATAGA AGGGAGCCTG GGACAGACCA AATGATGTCC TTGAAGAATG ACAACTCTCA 360

551

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GCACCTGTCA TGTCCCTCAG TAGAACTGTT GAAACCAAGC CTGTCAAGAA TCTTTGAACA 42 0

CACATCCATG GCAAACCTCG AG 44 2

(2) INFORMATION FOR SEO ID NO:1383:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 501 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 83:

GAATTCGGCC AAAGAGGCCT ATTCAGGTGT TTTCATTTGG TGATCAGGAC TGAACAGAGA 6 0

GAACTCACCA TGGAGTTTGG GCTGAGCTGG CTTTTTCTTG TGGCTATTTT AAAAGGTGTC 12 0

CAGTGTGAGG TGCAGCTGTT GGAGTCTGGG GGAGGTTTAA TACAGCCTGG GGGGTCCCTG 180

AGGCTCTCTT GTGCAGCCTC CGGGTTCATC TTTAGCAACT ATGCCGTGAG TTGGGTCCGC 24 0

CAGGCTCCAG GGAAGGGGCT GGAGTGGGTC TCAAGTATAA GTGACATTGG TGACACCAGA 3 00

TACTACGGAG ACTCCGTGAG GGGCCGATTC ACCATCTCCA GAGACAATTC CAAGAACATG 360

TTGTATTTGG ACATGAACAG CCTGAGAGCC GAGGATACGG CCGTGTATTA TTGTGCGGCA 4 20

AGGGATTGGT ATCATACTCG TGGCTATTAC TGGTACTACT TTGACTTCTG GGGCCAGGGA 480

TCCTTAGTCA GCGATCTCGA G 501

(2) INFORMATION FOR SEQ ID NO: 1384:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 634 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1384:

GAATTCGGCC AAAGAGGCCT ACTTCAATAT TCTGTTACGG GTTTTTTTAG TCTTTTTTTC 6 0

TCTTTGCTTT CCTGTGTTGG AATTTTCTAT TTCTATATAC TCAAGTTCAG AGATTCTTTC 12 0

CTTTTCCATA TCCTGTCTAC TAGTGAGCCC ATCCAAGGCA TTGTTCATTT CTGTTACAGT 18 0

GTTTTGATCT TTAGTATTTC TTTTTCATTC TTCATTACAC TTTCTCTCTG CTAACATTGC 24 0

CCATAAGTGC TTATATGCTG TATACTTTAT CTGTTGATCA TATTTGTTTT AAATTCCTAA 300

TCTGATAATT CAACATCTCT GACATGTCTG GTTCTGGTTC TGATACTTGT TGTCAAACTG 36 0

TGGTTTTTTT TCTTTTAGAG TGGCTTTTAA TTTTCTTTTT GTTTTTTGTT TTTTTTTTGG 42 0

ATAGTTGGAC ATGACGTACT AGATAAAAGC AACTACTGTA AATAGACCTT TAGGAATGTG 480

GTGGTAAGAT GTGAGAGGAA GAAAAGCATT CTGTAGTCCT GTTAGGTTTC AGTCTTTTAA 54 0

CCCATTTATG CTTAGTGTTC TATTACTGGA ACGCTAGGCA TGTGGAAGTT ATTTATATCC 600

TACTG CTAAA GGTTATCACC AAGCTGTACT CGAG 63 4

(2) INFORMATION FOR SEQ ID NO: 13 85:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 700 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 85:

552

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GAATTCGGCC
GGAAGAAAAC
TGAAGAAGAC
TTCTGAAAAA
AGGAGAAAAG
AGATGAAGAA
AGGGGAAGAA
GAAAGAAGAT
AGGAGAAGAT
AGATGGAAAA
AAAAGAGAGA
GAAAGAAGAT

AAAGAGGCCT ACTCAAGTTC AAGGAAAATG AAGACAAAAA GTGATATGAT
ATAGATACAA GTGCCCAAGC AGTTGCTGAA ACCAAGCAAG AAGCAGTTGT
TACAATGAAA ATGCTAAAAA TGGAGAAGCC AAAATTACAG AGGCACCAGC
GAAATTGTGG AAGTAAAAGA AGAAAATATT GAAGATGCCA CAGAAAAGGG
AAAGAAGCAG TGGCAGCAGA AGTAAAAAAT GAAGAAGAAG ATCAGAAAGA
GATCAAAACG AAGAGAAAGG GGAAGCTGGA AAAGAAGACA AAGATGAAAA
GATGGAAAAG AGGATAAAAA TGGAAATGAG AAAGGAGAAG ATG CAAAAGA
GGAAAAAAAG GTGAAGACGG AAAAGGAAAT GGAGAAGATG GAAAAGAGAA
GAAAAAGAGG AAGAAGACAG AAAAGAAACA GGAGATGGAA AAGAGAATGA
GAGAAGGGAG ATAAAAAAGA GGGGAAAGAT GTAAAAGTCA AAGAAGATGA
GAAGATGGAA AAGAAGATGA AGGTGGAAAT GAGGAAGAAG CTGGAAAAGA
TTAAAAGAAG AGGAAGAAGG AAAGCTCGAG

60
120
180
240
300
360
420
480
540
600
660
700

(2) INFORMATION FOR SEQ ID NO: 1386;

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH; 127 base pairs

(B) TV?E: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 138 6;

GAATTCGCGG CCGCGTCGAC CTTTAGTGTG TCTTTTCATT CTCTAAAAAG TGTCCTTTGC 6 0

AGAGAAAAAA AAAATTTTAA TTTTGATGAA AT CCAAC TTA TCAATTTTTC TTCTGTGGCC 120
CCTCGAG 127

(2) INFORMATION FOR SEQ ID NO: 1387:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 12 8 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 13 87:

GAATTCGCGG CCGCGTCGAC CTCTGTTCAG TCGTTTTGCT GAATATTTAT TAGCATTCCA 60
TCACTTTGTG TTTAATTAAT AGAAGTTGAG TTCAAACAAT GTTTTTAAAA TTCACACAAA 12 0

TACTCGAG 12 8

(2) INFORMATION FOR SEQ ID NO: 138 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 816 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1388:

GAATTCGGCC AAAGAGGCCT AGTTTCTTTT GCTCTACATC TTCACCAGTA TTTGGTGTTA 60

553

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TCAGTGTTCT GAATTTTGTC CATTCTGATA GGTGTGTAGA GGTATCTTAT AATTTTAATT 120

TGTGTTTCTC TGATGCCATA TGATGTGTGG GACATCTTTT CATATG CTGA ATTGCCATCT 180

GTATATCTTT GGTGAGGTGT CTGTTAAGGT TGTTGG CCAA TTTTTTAATT GGG TTGTTTG 24 0

TTTTCTTGTG GAATTTTAAG AGTTCCTTAC ACTGTCTCTG TCTGTCTTGT CTGTCTGTCT 3 00

GTCTGTCTGT NGAGACAGAG CCTCGCTCTG TCACCCAGGT TGCAGTACAG TGG CACAGTC 3 60

TTGGCTCCCT GCAACCTCTG CCACCTGGGT TCAAGTGATT CTCCTGCGTC AGCCTCCCGA 42 0

GTAGCTGGGT TTATACCCGT GCACCACCAC ACCTGGCTAA TTTTTGTATT TTTAGTAGAC 4 80

ACGGGGTTTC ACTANGTTAG CCAGGCTGGT CTCGACCTCC TGACCTCAGG TGATCCACCC 54 0

ACCTTGGCCT CCCAAAGTGC TGGGANGNGA GCCACCACAC CCAGCCTCCT TACACATTTT 6 00

AGTTAATAGT TCTTTATCAG ATGTGTCTTA TGTAAATATT TCCTCCCTAT CTGTGGCTTG 660

TCTTTTCATA CTCTTGACAT TGTCTTTTGC AAAAGACAAC AATTTTTAAG AAA CAAGTAG 72 0

ACAATTTTAA TGAAGTCTGG CTTATCAGTT CTTTTCTTCA TGGTTGGTAC CTTTGGTGCC 7 80

GTATCTAAAA GTCATCACCA AACCCAAGAA CTCGAG 816

(2) INFORMATION FOR SEQ ID NO: 138 9:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 163 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 89:

GAATTCGCGG CCGCGTCGAC CTAAACCGTC GATTGAATTC TAGACGAACT ATATGTTTAA 60
GCAAAAACAA AAATAAAAAT CCTCAAAAAA AGTAATATCA GAGTTTTAAT TTCAACCAGC 120
TGGCACAACA ATGAAAGTGT CAGACTTTCT GAAAGTACTC GAG 163

(2) INFORMATION FOR SEQ ID NO: 1390:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 286 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 90:

GAATTCGGCC TTCATGGCCT AAAACCCTCA AAAATAAATT AGAATCCAGC ACTGCTACAA 60

TATATTATCT AAAATGTCTA ATTCTCAAAA ATATGAGTGA TGCAAAGAAA CAGGAAACAG 120

TGAAACACAG AGGAAAAAAC AGTGACTAGA AACTGACTTA AGAGTAAGCC CAGATGTATT 18 0

TGGGAGCCAG AG CCTTCAAA GTAGCTATTA AATATGTTCG AAAAAATTAA GGGAAAATAT 24 0

GACAATGACT CAAAAATAAG GACTCTAAAT ATAGAAATGG GAGCTG 2 86

(2) INFORMATION FOR SEQ ID NO: 13 91:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 92 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 91:

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GAATTCGGCC TTCATGGCCT ACTTTTAAGG GCTTGGAAGT TTCAAAACCA CAGTCTGCAT 60

GTGACAGGTG CTCACTGCTG TTGGGTTGGC CGCTGGTTCT AGGCCTCTGC TGGAGTGTGT 12 0

GATCTGCTTT CTGACGGCAG GGCGTTCACA TGGGTGTGCT TTAAT CTTAC GTCTCCGTCC 18 0

TCTTTTTCCA CTGAGAGTGC TGGTCTCAAG GACAGTGGAG ATGAGAGAAT TGGAATATCG 24 0

CATAATGTCT CATCTGTTTT ATCTCTTGCT ACAAACATCA CAATCTCAAA ATAACAATGG 3 00

CAGTACAACT GCCACCTATA TCATTACTGA AAACAGTGAA GATATTTTTT GCCTAAGTCT 3 60

TCCCATTCTG TGTAGTTATG CAGAGTCTCG AG 3 92

(2) INFORMATION FOR SEQ ID NO:1392:

(i) SEQUENCE CHARACTERISTICS ;

(A) LENGTH: 2B6 base pairs

(BJ TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 92:

GAATTCGGCC TTCATGGCCT AGTAATCTTT CCCCCCAGTT TTTGGATGAA GAAACTAACA 6 0

CTGAAGGGGC GAGGTGGCCT CCCAGGCTCA GAGGGTGATT CAGAAT CCAG GCCTGGTGTT 120

CCTTCCACAG TACCAAAGCG CCACACATTA GTTGTCTTGT AGATTTTCCA CACTTCAGGG 180

AGAATG CCAA AGTATCTTTG CCTTGCACAC ACTACCTGTT CAACACTCAG TGACGAGGGT 24 0

GTCGTGTGTG CTCAGGCAAC TCCCGCCCTT CTTCCTTTTG CTCGAG 286

(2) INFORMATION FOR SEQ ID NO: 13 93:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 320 base pairs
<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 93:

GAATTCGGCC TTCATGGCCT ACTGAGTTCT CAAATCTAAC GTTTTAGGAA TTTTTTATTC 60

CTGCAGAGAG TTGGGGAGCT GTTTAAAAGT TGGTTGGTTT AGCCAGTATA GCTAGATTCC 120

TCAAGGTCAA CACAACGCCA TACTGCTCTA GCTGGGGCTA GATTTCTCAT GATAGTCTAA 180

ACTGTGTGAT GGCCAAGTCC CCACTTTGAA G ATGT CCAAA TTCAGCCTCA GACATTTCTC 24 0

CTCAAGAAAG GGGGGGCAAA AAAGCCTTTT GTGCCCCTTT CC CAAATTAT TTGCTCATGT 300

CGCAAGACTG AGGTCTCGAG 3 20

(2) INFORMATION FOR SEQ ID NO: 13 94:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 450 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1394:

GAATTCGGCC TTCATGGCCT AACGCCATCT ACGACCTGAT CGAGCGCATC GAGGATTTGG 6 0

CGCTGCAGAA CCAGATCCGG GAGCACGTCA TCTCCATCGA GGACTCGTTT GTGAACAGCC 120

555

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AGGAGTGGAC GCTGAGCCGC TCCGTACCGG AGCTTAAAGT GGGCATAGTG GGGAACCTGT 180

CTAGCGGGAA GTCAGCCCTG GTGCACCGCT ATCTGACGGG GACCTATGTC CAGGAGGAGT 24 0

CCCCTGAAGG GGGGCGGTTT AAGAAGGAGA TTGTGGTGGA TGGCCAGAGT TACCTGCTGC 3 00

TGATCCGAGA TGAAGGAGGC CCCCCTGAGC TCCAGTTTGC TGCCTGGGTG GATGCAGTGG 3 60

TGTTTGTGTT CAGCCTGGAG GATGAAATCA GTTTCCAGAC GGTGTACAAC TACTTCCTGC 420

GTCTCTGCAG CTTCCGCAAC ACCCCTCGAG 4 50

(2) INFORMATION FOR SEQ ID NO: 13 95:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 276 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 95:

GAATTCGGCC TTCATGGCCT ACCGTCATTC ATTGCAGGGA CCATCAAACC CCAGACAATC 6 0

CTATTTTGGT GGGAAATCTA GCAGATAGAG AAGCCAAACA AGTAG CCCT A CAACCTGTAC 120

AAGG CCAGTT TCTGTGCCTG TCCTCGTTCT CTCCTCTTTA CTCTCCAGAA GAAAAGGAGG 180

ACTACCAAGC CCAAAACCTT CAAAAACAAG GACCATGGTA TGTCAAGGAA GGGTGCTTCC 240

TTCTTCCTCA CTCTCAAACA AT CTCTATCC TTCGAG 276

(2) INFORMATION FOR SEQ ID NO: 13 96:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 241 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1396:

GAATTCGGCC TTCATGGCCT AGGGGGCGGG GGGCGGGGCG GGTCTCAGAA ATCAGGAGTA 60

ACTCTTTGAA AACTAAATAG TTTAAAATCT CATCCAACTT CCACCTAACT TACATGCCTG 120

GTTAACCGAC ACTCTGTATA TCCTGTATAA AACATTCTAA CTGATGCCCA CGACATACTA 180

TTGGCTGATG GTTTTGCTAG TATACAGTAT GGCCACTTAC TGCCATTCCC ATGCCCTCGA 240

G 241

(2) INFORMATION FOR SEQ ID NO: 1397:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 314 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 97:

GAATTCGGCC TTCATGGCCT AGAAAATGAA G AAGAAG AT C ATCAAGGACC AGAAACTGCT 60

TGTGATCGTG GGGGGCATGC TGCTGATCGA CCTGTGTATC CTGATCTGCT GGCAGGCTGT 120

GGACCCCCTG CGAAGGACAG TGGAGAAGTA CAGCATGGAG CCGGACCCAG CAGGACGGGA 180

TATCTCCATC CGCCCTCTCC TGGAGCACTG TGAGAACACC CATATGACCA TCTGGCTTGG 240

556

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CATCGTCTAT GCCTACAAGG GACTTCTCAT GTTGTTCGGT TGTTTCTTAG CTTGGGAGAC
CCGCAACTCT CGAG

300
314

(2) INFORMATION FOR SEQ ID NO: 1398:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 342 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

fii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 98:

GAATTCGGCC TTCATGGCCT AGTGCACACC AAGAACCAAG TTTCAGCTTG GTTACTGTGT 6 0

TGAAGACACC TTTGCTATAT TTCAAGTCAT TCCTTCTTTT CTCAATTTTT TTTAATTGAC 12 0

AAAAATTTTA TATATCG TGT ACAACATCAA TCCATCTTGG CATCTGTATT TGTCAGGGTT 180

GTCTTAGAGG GACAGAACTA ATAGGATATA TATAAGGGGG AG TTTATTAA GTATTAACTT 24 0

ATATAATCAC AGGGTCCCAC AACAGGCTGT CTGCAAGTTG AAGAG CAAGG AGAGCCAGTC 3 00

AG AGTG CCG A AAC TGAAGAA CCTGGAGTCC GATGTTCTCG AG 3 42

(2) INFORMATION FOR SEQ ID NO: 13 99:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 614 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13 99:

GAATTCGGCC TTCATGGCCT AGGGCCATGT TGGTTAGAAT GGTGCCATAT TTTCTG GGAT 6 0

AGCACCATGC TGGCTGGGAT GGTGCCATGT TGGCTGGGAT GGCACCTGCC TCAGCCTCCC 12 0

AAATAGCTGG GATTACAGGC ATCTGCCACC ATGCCTGGCT AATCTTTTGC ATTTTTAGTA 18 0

GAGAAGGGGT TTCGTCATGT TGTCAGGCTG GTCTCTCACT CCTGAACTCA GGTGATCCGC 24 0

CTGCCTCGGC CGCCCAAAGT GCTGGAATTA CAGGCATGAG CCGCCACGCC TGGCCTTTTA 300

CTTGAGTTTT AATAGGATCG CTCTTGCTGC TATTGAGGAT AGTACATATG GGGTAATGAT 360

GCAAGCAGAG AC CTACTGTA GTACTCTTCA GGAGAGAATG GTGGCTTGCA CAAGGATGGA 420

AG CAATGAAG GTGGTGAAAA GTGGTCAGTT TCTATATTTA TTAGGAAACA CCTAGGATGA 4 80

TATCTTAATA GACCAAAATG TGAAATGTAA GAAAAATAGA GATGTCAAGA TGACACAAAG 54 0

ATTTTTGGCT TTGACAACTG AAAGAAT AG T TACTATCAAC TGTGATTGGT AACAATGCAC 6 00

ATGGATCTCT CGAG 614

(2) INFORMATION FOR SEQ ID NO: 1400:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 244 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1400:

GAATTCGGCC TTCATGGCCT AGTTCTATTT AAAAAATAAA CAACTAGACA ATTAACTAGT 60

557

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TTATTAACCT ATCACAATTG AATTTTTTTT TAATTTT CAG TCTTAACACA TTTTTTAAAA 12 0

TGTATTAAAG TAATACATTG TAG TAG TAGG ATTATATACT CCTTGGCTGA GAATTCCAAG 18 0

TACTGTGGTT CTACTGTTTA GTGGAAAACT CTGGAAGTTA AAATATAGAA TATGAAACCT 24 0

CGAG - 244

(2) INFORMATION FOR SEQ ID NO: 14 01:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 325 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 14 01:

GAATTCGGCC TTCATGGCCT AAAACAAACA AAAAATTATC TGAATG AT C C TGTCTCTAAA 6 0

AAGAAG C CAC AGAAATGTTT AAAAACTTCA TCGACTTAGC CTGAGTCATA ACGG TTAAGA 12 0

AAGCACTTAA AC AG AAG CAG AGGCTAATTC AGTGT CACAT GAGGAAGTAG CTGTCAGATG 180

TCACATAATT ACTTTCGTAA TAGCTCAGAT TAGAATGG CT ACCCCATTCT CTAGACAAAA 24 0

TCAAATTGTC CTATTGTGAC TCTTCTAAAA ATGAAGATGA AGAGCTATTT AATGACACAC 300

CTTGGATTAA AACGGGAAAC TCGAG 325

(2) INFORMATION FOR SEQ ID NO: 14 02:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 364 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:14Q2:

GAATTCGGCC TTCATGGCCT AAAAGAAAAG AGAAAGTGTT ATTTTCCTGT TAGTGACATG 6 0

TAGTCCCTTT GTTCTAGTAG GAAAAAAGGT GCCTAGAGGT AGTATATAGA GTAAATATTG 120

TTCCTTTAGC CTACTTCCTG CAGCTTCCAA TTTATCCAAG GAAATGTCTA CAACAATTTT 180

GTTCAAAAGT CTGTTCTAGT CAATAGCAGG AGAAGTCCAC GTTATTGGGC TGATTTTGCT 24 0

TACATCAGCA AGAGAAATGT CACGTGATAC TCAGGCCGCG CTTTCTCTTC CATCACACCA 300

TCTTCAAGGA ATGTCAATAA ACCCACTTTG GCTAGGCAGG ATTGAATTCT AGACCTGCCT 360

CGAG 364

(2) INFORMATION FOR SEQ ID NO: 1403:

(i) - SEQUENCE CHARACTERISTICS:

(A) LENGTH: 262 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1403:

GAATTCGGCC TTCATGGCCT AGTTAGGGAC TAACATTTGT ATCAACAGTT GATAAATGTC 60
TAAGATTGTT TATTATACAG CAGGGTACAA TGGTAGTGCT AATGCCAACA GGGCACCATG 120
GAAGTTAGTC TAAAAATTAT CGCTAGGCTT TATACAAGCA ACAACATATG CTGCTGCTCT 180

558

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TAGAATTTTG GGAAATGATC TGCTTCTAAT ACTAAGCAGT TCTTTAACAT TTTTAAATAT
TGAATTCTAG ACCTGCCTCG AG

240
262

(2) INFORMATION FOR SEQ ID NO: 14 04:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 96 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 04:

GAATTCGGCC TTCATGGCCT AGCAATTTGC TTCAGTTTCC TTATGTTTGC CTTTCTCATC 6 0

TGTCCTCTTT TCCATTTTAT TCCTACTCTG TCTCAGTCCA CTTACAGTTA TATTTCCTAT 120

CTGTGTATTT TATAATATTT GTGCTTTAAT ACTTTTAAAA TATCCTTTAT TTTACTGTTT 180

CTTCTCTTCC CTTGTCATAT TTTAAAGTGT TTTATTTCTC AGCCTTCTAT ATCTTTGCAT 24 0

TAATTCTGTT CCTCTACAAT AGAGTCCGTT CCAAGCTTTC TGTCTTCCTG TGTCCTTCCA 3 00

CGGCTCTGGC TCTCTCTGCA TTATTTCCTA TTTATGGAAT ACAAATCTTT TACCCTTGTA 3 60

TTTTTCTCAC TCCTCTCCAC ACACCCCCGA CTCGAG 3 96

(2) INFORMATION FOR SEQ ID NO: 1405:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 444 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

Ui) SEQUENCE DESCRIPTION: SEQ ID NO: 14 05:

GAATTCGGCC TTCATGGCCT AGACCAAAAT GTCTGCCCAG ATAAAGGATA CATTGTGCAT 6 0

ACATACACTG GGGAGAGGCA GACAAAAAAA CAATGTAGTT TGAGTGTGTG TGCGTGCTTG 12 0

CATGCGTGCA TGCAGGCATG TG CAT ATATA ATG CTAAAAC ATGATAAGTA CTATTAAAAA 180

AACAGGTTAG GGTGATTGAA ACTACTAGGG TATGAATAAG AGTGGGTTGC AATTTAAAGT 24 0

AGGGTCATTG TGGTTGGCCT TATTGAGGTG ACATTGGAGT CAAGACTTGG AAGAAGAAAG 3 00

GTTGTTGGCC ACACAGCTAT TGAGGGAAAA ATGTTCCAGA TAGAAGAAAC AGTCAGGGCA 36 0

ATGCCTTGGG ATGGAATCAT GCATAGAGTA TTCACAGAAT AG CAAGG AAG CTCTAGTTCT 420

AAAGTAAAGT GACTGAGACT CGAG 444

(2) INFORMATION FOR SEQ ID NO: 1406:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 363 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 06:

GAATTCGGCC TTCATGGCCT ACCTAGAAGG TAGTAATGAT AAGCATTTAA TTAGAAG TAG 6 0

GCCTGAAGTT TGCAGTGCAA TG CAGTAAG T AT TTACCGAG TGATTCATAT GAGTAAGGAT 12 0

GTGATAGCTG CTATAAGAGC TGCAAAGTTT ATTAAGATAC ATCCCTGTCC TGGAAACACT 180

559

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GCCAGCTTCG ATGAGAATAC AACAATG T T A GATATATTCG TTTTGGAAGA TACCTTTCCC 24 0

CCAGTTATTT TCATTTCACA GCTTCTCCAG CCTCCTTCAG CTTCTGTTCT CCCTCTTTGC 3 00

TTTTCTGTCT CAATTTTCCT GCCCAGCCCT AAATTCACAG AGTAAATCCA CCAGAACCTC 3 60

GAG 3 63

(2) INFORMATION FOR SEQ ID NO: 14 07:

<i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

<ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 07:

GAATTCGGCC TTCATGGCCT AGGCTTCAGG GATAACCACG TTCAGGTGGG TTAGACACAC 60

CTCCTGTGGG AGGGTGATTG CAATTAGCTA TCATAAGGCA GGAGACACAA CAGCAACTTA 120

AATTATCCAC AAGCAGAATC ATGAGCTGTT TG CAAAGGG A GTTTCCATCG CAAGACAGTT 18 0

TCACTGTATT TAAGCGAGAT CCTGCCCTCG TACACGATCA CCGCTCGAG 229

(2). INFORMATION FOR SEQ ID NO: 1408:

<i> SEQUENCE CHARACTERISTICS:

(A) LENGTH: 512 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 140 8:

GAATTCGGCC TTCATGGCCT AGGCTTCTAG AACAAGAATG TAGGCAGGCT CCCAAATGGA 60

GAGGTAAACA TGACCG CGTT GTTTGAAACT ACTTCATTAA TTTGTAAATC AGAACCAAAA 120

AGCTCTGGCC CTCCCACTTC TCTTAG CTGA CCCTCCTCCC CACTTACGGA TAAACAGACT 180

TTAACTTCCC TAACCCAGAA ACACTTCCAC CAAAAATGTA TGGTTATACC TTATCCTAAA 240

AAGGCACCAT GCAGGCATTT AAGACTGAAC CAGTGAACTC TAAATATGTA GTAGTAGAAA 3 00

ATATCACTAA TCAAAACTTC CAG CAT GAGA TGGTACAAAA CCCCAAGAGG ACTGGTGACA 3 60

TGTACCCCGG GATGGCAACC CCAGCTTCTG GCAACCCCAC AGCCCAGCGG GAGCTTCAGC 4 20

TCTGGTCAGG TGCACGGCTG CCAAAGTCTG CACACCTTGG GGACAAGGAA AGGAGACACT 4 80

TGCTTCATTG TGCTATTCAT GACCCAGTCG AG 512

(2) INFORMATION FOR SEQ ID NO: 1409:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 262 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 09:

GAATTCGGCC TTCATGGCCT AATGGATTAT ATT TCTATAA CAGTTAGAGT ACTATTCCAT 60
TTATCTCTTT CATTTTGAGT AAAGTTTGGT AGTTTAGGGA GGAATTGATC AATTTCATCT 120
AAATTGAAAG ATTCAGGTAC ATAAAGTTGT TGTTATATTA CTTATTATTC TTTTAATGTC 180

560

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TGTGGGGTCT AGTGATGTCT CCTCTTTCAG TTCTGATATT GGTAATTTGT GTCTTCTCTC
TTTTTGTGCC AGCATGCTCG AG

240
262

{2) INFORMATION FOR SEQ ID NO: 1410:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 441 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO; 1410:

GAATTCGGCC TTCATGGCCT AGGGAGGTGG TTTCTCTATC ATTG C ATGAG GTAAGAGTCT 60

GGCCCTGGAT GCTAAGGCTG CAGTTTTCTA CAGAAAGGAG TCATCTCTGT GAGGCAGCAT 120

CAGCCTCCAA GACACAGTG I GCTGACCTGG TTTTGTATAA AGATGAAAAC AGCTGTTCTC 180

AACTGGCTGA GGCCGGCCAC AGAGAGAGCG GCGGGCTCAG CCTTCACAGG ATTGTCCTTC 24 0

CACTAAAGGG TAGGGGGTTT TAATCATCGC AGAAAGGAAG TGGGGGTGAA GGTCAGGAAA 3 00

AATAGAAGCA CGAATTCACC CCTCAGGCCT CAGCTAGAGG AAGCTAAGAG AAGAAATGAG 3 60

ATTGCATAAC TGTTAAGAAA AAGGCAAAGC TGGAGAGAAT GCAGAGGATT CTGGTTCCTG 420

GAGAGAACCT TCAGACTCGA G 441

(2) INFORMATION FOR SEQ ID NO: 1411:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 79 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1411:

GAATTCGGCC TTCATGGCCT AATTCATTGT CTGG TCCTTT ACAAAAGACA TATGCTGGCT 60

CCTGCTCTCT GTGGATGATA GGTCTACAAA GATGTGATTC AACTCATATA TGTCTCCAAA 120

TTTATATATT AATT CATATA CTGTTTTGTC TTACATTAAT CTAGCATTGT CTTTTGGCTT 180

GCTACTGCAG TAAGTTACCT TCTAATTCAT CATTAGGTCA ACTTTATCAA CTCACCTAAG 24 0

TCCAAAAGTA AATGTAGGTT TCTCCTGGGT TCTTTTGCCT CTTAAGTTTT GCCATCCCCA 3 00

AATAAGCACA ACAGAGACCT G CACCAAG AG ACCTTACTTT TAGACTGTAA GCACCAAAGT 36 0

GATTTCTGTA GAGAGAGTGA GCCAGGCTCA GTCTTATGAC TGGCAATACA AGTTGAGGGT 42 0

AGGAGCTTTG GACAGAACAC TAGCTATGTA TAGTGTTGTC TAGGTGAGTG CTTCTCGAG 4 79

(2) INFORMATION FOR SEQ ID NO: 1412 :

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH ; 4 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1412:

GAATTCGGCC TTCATGGCCT AGCCGATTTA TAAATATGTA TATATAAC CT TTCCCTTTTT 60
GAGAGATCTC TTAGTAATAG TCAAAGCCAT ACCCTATTCC TTAGTGAGAA AGCCAGTTTG 12 0

561

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AAACGAATGT AG C AATAG AT GTAAAAACAT TTAAAGGCGT TTTAATGTGG CTTTTTAATG 180

AGCTGGCTTA TGCCTGTAGT CCCAGCACAT TGGGCAGCTG AGCTGGGAGG ATCGCTTGAG 24 0

CCCGGGAGTT CAAGACTAGC CAGGGCAACA TAGTGAGACC CCATCTCTAT TTAAAAAAAA 3 00

ATGTTTTTAA AGATAAGGAA CAGACTTAAA GTGATGATTG ATTG CTCATA GAACGTTCAT 360

TTTGGGCTCC AGAACTAGGA ATGATG TAG A ATTTATTGTT GTGTCATTGT CTCATTAAAT 4 20

GCTGTAGTTT CCTATGTCCT TGCCTACCTT CTTTCCTCAG AGCCTCGCAT CTGACCCTCA 4 80

GAG AG T AG C A GCTCGAG 4 97

(2) INFORMATION FOR SEQ ID NO: 1413:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 43 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1413:

GAATTCGGCC TTCATGGCCT ACAGGAACAA AAAATGCTAT GCTATTATCT CAAAAATGCA 60

TACTCCTTCC TACTTAAGAA TAATAAATTT ATATATTATG ATATGGTAAA ATTCACAACT 12 0

AATTGTATTT TTCCCTAGAA TGTTTAAAGC ATTATCTAAT ACCAGCTTCA GTGTCTATAT 18 0

TACTGTAACT T CATG AAAGA CTACTAACAA TACTGGCTAT CATTTATTAA TATTAAGTAG 24 0

TACTTGCCAG ATGCCGTTAG AGGTGCTTTA AATGCATTCT CATTTAGTCT TCGTGTGTAC 3 00

TACCGTTATC TTCACTTTTT AGATAAGGAG ACTAAAGTAT AACTAG AG CT AAGAAACATG 36 0

AGAAAGACGA CCTAGCTACT GCCTATTTTG TAATTCCCAT GGACTAAGCT TGGAGAAGTA 42 0

AGAACTATTA CTACTCGAG 43 9

(2) INFORMATION FOR SEQ ID NO: 1414:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 3 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1414:

GAATTCGGCC TTCATGGCCT AGCCACTTCA AGACGGCAAG TTATTTTAGC TCCTGTCTAA 60

ATAAGTTAGT GGGCTCCAGT CCTTAAACCA CTATTTTCTT TATTAATTCC TCAAGTACAG 120

ACTTTTGTAT GTAACCAGTC TTTTTAAACC TGTGTATAAT GACTCATTAA TGAGTTGTAA 1B0

AATAAATGTA GTGAGTTATG ACCAATATAA AAAAATAGAA AAGGCCAGGC ACAGTCGCTC 24 0

GAG 243

(2) INFORMATION FOR SEQ ID NO: 1415:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1415:

562

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GAATTCGGCC TTCATGGCCT AGTCTTCCAA GACAGGAATC AGCAACCTTT TTTTGTTTTT
CTGTATCAGT AATTCATTCT GTATATTTTA AAAAGTTTTA ACCTCTTCTT CCTAGCCCTC
CAGTATTTGT TTATAAATTA AAACGTTT C C CAAAGTGTTT TCTGTGAAAC AATAGTTCTA
AAAGGTGCTC TAAGAAAAGC TAAGTACATG GCAAAATCCA AAGTATATGT TTTATTCATT
ACATTTGATG AATTTTTTTT GTTTTTTCCT CTCGAG

60
120
180
240
276

(2) INFORMATION FOR SEQ ID NO : 1416 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 341 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

( i i ) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1416:

GAATTCGGCC TTCATGGCCT AGAGAGCAGG TTTTAGCTTG CATCCAGCTG TTTCTTGAGT 60

GATGTGTACA GCTTACCCCC AAAGAGGCAA CTGAATTTCA GCTGCTCTAA TACCCACACC 120

CTCAACTTAG GTTTAGTCAT AATAAAAAAC AGAATGGATT TGTTAGTTCC ATTGATTGCC 180

ACAAACCTCA CCTTCTGTGT GGCAGAGATG TGCTTTAGTT CTTCATTGGA ATG TTACTTT 240

CAGATCTCAC AAACCTCAAA CCTAGGGCAC CACCAATGAC AAAGAGAATG CTAAATAGAT 3 00

AAATC CTTTG CCAGGTCTTC AAGCTTTCCA CTCCCCTCGA G 341

(2) INFORMATION FOR SEQ ID NO: 1417:

(i) SEQUENCE CHARACTERISTICS :

(A> LENGTH: 455 base pairs

(B) TYPE: nucleic acid

<C) STRANDEDNESS: double

<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1417:

GAATTCGGCC AAAGAGGCCT AGCCATTATT ATTAAAAAGT AGGATTGCTA CCCGCCATTA 60

CTATTAAAAA GTAGGATTG C TACCCGCCAT TATTATTAAA AAGTAGGATT GGTACCCGCC 120

ATTATTATTA AAAAGTAGGA TTGCTACCCA ACATTATTAT TAAAAAGTAG GATTGCTACC 180

CTCCATTATT ATTAAAAAGT AGGATTGCTA CCCTCCATTA TTAT TAAAAA GTAGGATTGC 24 0

TACCTGCCAT TATTATTAAA AAGTAGGATT GCTACCTGCC ATTATTATTA AAAAGTAGGA 3 00

TTGCTACCTG CCATTATTAT TAAAAAGTAG GATTGCTACC CGCCATTATT ATTAAAAAGT 360

AGCATTGCTA CCCGCCATTA TTATTAAAAA GTAGGACTGC TACCCGCCGT TATTTGCACA 420

GCTACCTTAT GAAAGTAGTT TCACGCTGTC TCGAG 4 55

(2) INFORMATION FOR SEQ ID NO: 1418:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 573 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 141 8:

GAATACCTAG CTTCCATGAT TTATGATAGA TATCCTTTAT TGGACCAATT CGTGTCTGTA 60

563

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ACCAGCCTCC TGTTTCTACT GCCATCCCCT CCTCATGCAC AGATGCCTCC TCCCTTGGCT 120

CCTGCTCTGA TCCCTGTACC CAGCTTGTCC CCTGCAAGCA TGTTCCCCTC CCTTGCCCAG 180

GCTCTGACAC CCCACACATG TGTGGATCCC CTCCCCTGTC CCAGCTCTGA TACCCCTTGC 240

ATGTGTGGCT GCCCCTCACC TGGGTGTCCT CTTCCCTGTC CCAGCTCTGA CACCCACGCA 3 00

TGTGGGGCTG CCCCGTGCCT AGGTGTCCCC TCCTCTGCTC AGGCTCTGTC CTCCTG CGGT 360

TGGCTTTCCC ATTCTGGATG CACCTCACAC AGAGCCTTGT CATCTTTGGA TGAATTTGGC 4 20

CTCCCCCATC CACTGCTGGT GCAGATGCTT CCTTACGGGG CCTTGTCTGA TGGCTTTAGG 4 80

G C TGAAT CAT GCAGGAAGGA AGGAGAAGGA CAAGAAGAAA AGGGAAGGCT GGGAAGGGAA 540

GCGGGTGGTA AAATTGGTTC ACAAGCCCTC GAG 573

(2) INFORMATION FOR SEQ ID NO:1419:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 188 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1419:

GAATTCGGCC AAAGAGGCCT ATTTTAAAAA AAACTATTTA ATTTTTTAAT TTATTTTTGG 60

TTGTTTTTTG CACAATGAAG TTTCAGCTTC TCAACCTTCT CCCCTACCCA GGGCTGTGGA 120

CCCAGACTGG CCTTGAGCCA CAGTCCCTCT TTCCCTCCTC ACCCTCTTCC CCCTCCGGGC 180

ACCTCGAG 188

(2) INFORMATION FOR SEQ ID NO: 142 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 572 base pairs

(BO TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1420:

GAATTCGGCC AAAGAGGCCT ACGAGGAAAG AT CT AATTAT CATGGACCTG CGACAGTTTC 60

TTATGTGCCT GTCCCTGTGC ACAGCCTTTG CCTTGAGCAA ACCCACAGAA AAGAAGGACC 12 0

GTGTACATCA TG AG CCTCAG CTCAGTGACA AGGTTCACAA TGATGCTCAG AGTTTTGATT 180

ATGACCATGA TGCCTTCTTG GGTGCTGAAG AAGCAAAGAC CTTTGAT CAG CTGACACCAG 24 0

AAG AG AG CAA GGAAAGGCTT GGAAAGATTG TAAGTAAAAT AGATGGCGAC AAGGACGGGT 3 00

TTGTCACTGT GGATGAGCTC AAAGACTGGA TTAAATTTGC ACAAAAGCGC TGGATT TACG 3 60

AGGATGTAGA GCGACAGTGG AAGGGGCATG AC CTCAATG A GGACGGCCTC GTTTCCTGGG 420

AGGAGTATAA AAATGCCACC TACGGCTACG TT TTAGATG A TCCAGATCCT GATGATGGAT 4 80

TTAACTATAA ACAGATGATG GTTAGAGATG AGCGGAGGTT TAAAATGGCA GACAAGGATG 540

GAGACCTCAT TGCCACCAAG GAGGGTCTCG AG 572

(2) INFORMATION FOR SEQ ID NO: 1421:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 98 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1421:

GCAAGACGGC TACTGAGGCA GGAGAATCGC TTGAACCCAG GAAGCGGAGG TTQCAATGTG 6 0

CCAAGATCGT GCCACTGCAC ACTCTAGCCT GGGCAACAGA GCAAGACTGT GTCTCAAAAA 120

AAAAAAATCT TNGACNAAAC ATAGTTGTTN ACATACTTCT TTAATCCCAG AGTTAGTTTT 180

AAAAANNACA TGATTGCTGT TTTTGCATAT TATCTCAGCG GTCTAAAATT AACCTAGCCA 240

TGTGCAGGAA TGGGTAAAGT CCCCTTAAAC AAAAATGGGG TTAGTTANGT TAGTTCTTTT 3 00

GCCATTTCAC TGGTCATATA CCTGAAGCGC TTAG CCTGAC ACAATTGAAC GCCAGACGGA 3 60

AGCCGNGATC AGCGGTCCTG ACGGGGGTCA GAGTCAGACC AGGGGTCTTT TACCCAAGTG 4 20

GGGAAGATTG GGAAAGGCCT AGGATCAGAG AGGGAAATGG GTCCCTGGTT GCCCATGGAC 4 80

CTAATGGGGT CTCTCGAG 4 98

(2) INFORMATION FOR SEQ ID NO: 1422:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 827 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1422:

GAATTCGCGG CCGCGTCGAC GAGGAAACCA GCCAAGGACT AACTACG A C C ATGAGATTGG 60

CAGTGATTTG CTTTTGCCTG TTTGGCATTG CCTCCTCCCT CCCGGTGAAA GTGACTGATT 120

CTGGCAGCTC AGAGGAGAAG CTTTACAGCC TGCACCCAGA TCCTATAGCC ACATGGCTGG 180

TGCCTGACCC ATCTCAGAAG CAGAATCTCC TTGCGCCACA GAATGCTGTG TCCTCTGAAG 24 0

AAAAGGATGA CTTTAAGCAA GAAACTCTTC CAAG CAATTC CAATGAAAGC CATGACCACA 3 00

TGGACGACGA TGATGACGAT GATGATGACG ATGGAGACCA TGCAGAGAGC GAGGATTCTG 3 60

TGGACTCGGA TGAATCTGAC GAATCTCACC ATTCGGATGA GTCTGATGAG ACCGTCACTG 4 20

CTAGTACACA AG CAGACACT TTCACTCCAA TCGTCCCTAC AGTCGATG TC CCCAACGGCC 480

GAGGTGATAG CTTGGCTTAT GGACTGAGGT CAAAGTCTAG GAGTTTCCAG GTTTCTGATG 54 0

AACAGTATCC TGATGCCACA GATGAGGACC TCACCTCTCA CATGAAGAG C GGTGAGTCTA 600

AGGAGTCCCT CGATGTCATC CCTGTTGCCC AGCTTCTGAG CATGCCCTCT GATCAGGACA 660

ACAACGGAAA GGGCAGCCAT GAGTCAAGTC AGCTGGATGA ACCAAGTCTG GAAACACACA 720

GACTTGAGCA TTCCAAAGAG AGCCAGGAGA GTGCCGATCA GTCGGATGTG ATCGATAGTC 780

AAGCAAGTTC CAAAG CCAGC CTGGAACATC AG AG CCACGG CCTCGAG 82 7

(2) INFORMATION FOR SEQ ID NO: 1423 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 B base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1423:

GAATTCGCGG CCGCGTCGAC GGGAGAGGAA GGGTTGGGCA GGATGGAATA TTAAATTGTA 60

ACATGATAAA CATGCAAGAC TGTTATCCAA TCTAGATAAT TTATATACAT TTTGATGACT 120

TAGGAAAACA AAGCAATCAT TTGTGACAAG CCTAAAAAGC TTGACATATT TAACATACTT 180

AGGAACTTTT TTTGTGCGGT GGGAATTCTC TAATTGTATC ATGTGGGCCT TTTGAAAGTA 24 0

ACAAACAGAA GGCCAGTCTG TTGCAAGTTT GCTGCTGAAC ATCACATTCC ACCCTAAGAA 3 00

AACACAAGGT GGATTGCATC GAGGGTGGAT ACCTTACCTT AGCACAGA 34 8

(2) INFORMATION FOR SEQ ID NO: 1424 :

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(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 152 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1424:

GAATTCGCGG CCGCGTCGAC TTGGAGAATG TGGCCTCTGA TCACTAACCA GGGTTTTCTC 6 0

TTTACACTGG CTTGTTTACT TATTTCTTCA CCAAAGCCAG GGAACGTCCC TTTAGCTACT 12 0

GCAGCATTTC TAACAGATGC GACAAATCAC AG 152

(2) INFORMATION FOR SEQ ID NO: 1425:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 206 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 142 5:

GAATTCGCGG CCGCGTCGAC CTAAACCGTC GATTGAATTA GACCTGCCTC GAGATGCGCC 60

ACTTTCTGCT CACCCACCTT AGAGCCTTTG CATATG CAGT TGCTTCCTCA GAGTATTGCC 120

ATCCCCAGCA CGACCCCCAG CTCATT CTTC AGGCCACTAA CGTAAATGTT ACTTTCTCAA 180

AAACACCCTC TCCATCCCGG CACCCA 206

(2) INFORMATION FOR SEQ ID NO: 142 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 353 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1426:

GAATTCGCGG CCGCGTCGAC GTGGGTACTT CATCCTCCTC ATCACTGGTT GGCACTGAGA 60

GCTTCTTAAG ACGCTCCATG AGCTCTTTCT CTTCTCCATC ATCATCCACA TCCTTCTTCC 12 0

GCCTGCCTTT TCGGGTATCT CGCTTTTTTT TTTGCTGCTG TTGCTGTTGC TGCTGCTGCT 18 0

GCTCCTTCTC CTTGAGCACT TTCTCTTCTT CCCCAGCCTG TTTATCTTCT ACTGCCAGCT 240

CTTCAAAGAA CGTTTTTTTG ATCTTCTNGT CCTTCTTCCC TTTCTTCACC ACTTTGTCTG 3 00

ATGGGCTCGT GCTCTCTCCG TCCCCGATCC ACT CGGGCTC CGGCGGACTC GAG 3 53

(2) INFORMATION FOR SEQ ID NO: 1427:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 343 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

566

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(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1427:

GAATTCGCGG CCGCGTCGAC AGATATTTGG TTATCTTGAC TTTTTAAAAT AACATATTTC

TACAGGATTT TGAGTCTGAG AAGAGAAAGG TAATATGCAA GACACTTCGA TTTGTTGCAC

ATTATTATGG AGCATCATTA ATGGTTTGTA CATTTCTTGT CCTTTGGGCT TGAATGGACA

GTACCAAATT TGGGGAAATC AGCAACTTGA TGCACAGCTA CGAGGAATAA ATGCTTTTGC

TAATGCACAT GGTCCCGTTG CTTTCCCACT GCTGAAGACC TCTCCTTACA GAGTGTTTGA

TAATG CATCT GTTGAACATG CACTGCTAGA TGGTCCTCTC GAG

60
120
180
240
300
343

(2) INFORMATION FOR SEQ ID NO: 1428:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 54 2 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1428:

GAATTCGCGG CCGCGTCGAC GAGGGGAAGA TGTCACGCAA GATAGAAGGC TTTTTGTTAT 6 0

TACTTCTCTT TGGCTATGAA GCCACATTGG GATTATCGTC TACCGAGGAT GAAGGCGAGG 120

ACCCCTGGTA CCAAAAAGCA TGCAAGTGCG ATTGCCAAGG AGGACCCAAT GCTCTGTGGT 180

CTGCAGGTGC CACCTCCTTG GACTGTATAC CAGAATGCCC ATATCACAAG CCTCTGGGTT 24 0

TCGAGTCAGG GGAGGTCACA CCGGACCAGA TCACCTGCTC TAACCCGGAG CAGTATGTGG 3 00

GCTGGTATTC TTCGTGGACT GCAAACAAGG CCCGGCTCAA CAGTCAAGGC TTTGGGTGTG 360

CCTGGCTCTC CAAGTTCCAG GACAGTAGCC AGTGGTTACA GATAGATCTG AAGGAGATCA 42 0

AAGTGATTTC AGGGATCCTC ACCCAGGGGC GCTGTGACAT CGATGAGTGG ATGACCAAGT 4 80

ACAGCGTGCA GTACAGGACC GATGAGCGCC TGAACTGGAT TTACTACAAG GACACTCTCG 54 0

AG 542

(2) INFORMATION FOR SEQ ID NO: 142 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 465 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 142 9:

GAATTCGCGG CCGCGTCGAC TTAAGAGTCT GCTTCGGAGA CCGTAAGGAT ATTGATGACC 60

ATGAGATCCC TGCTCAGAAC CCCCTTCCTG TGTGGCCTGC TCTGGG CCTT TTGTGCCCCA 120

GGCGCCAGGG CTGAGGAGCC TGCAGCCAGC TTCTCCCAAC CCGGCAGCAT GGGCCTGGAT 180

AAGAACACAG TGCACGACCA AG AG CATAT C ATGGAGCATC TAGAAGGTGT CATCAACAAA 24 0

CCAGAGGCGG AGATGTCGCC ACAAGAATTG CAGCTCCATT ACTTCAAAAT GCATGATTAT 3 00

GATGG CAATA ATTTGCTTGA TGGCTTAGAA CTCTCCACAG CCATCACTCA TGTCCATAAG 3 60

GAGGAAGGGA GTGAACAGGC ACCACTAATG AGTGAAGATG AACTGATTAA CATAATAGAT 42 0

GGTGTTTTGA GAGATGATGA CAAGAACAAT GATGGCATAC TCGAG 4 65

(2) INFORMATION FOR SEQ ID NO: 143 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 73 base pairs
<B) TYPE: nucleic acid
(C) STRANDEDNESS: double

567

WO 98/45437

PCT/US98/06956

(D) TOPOLOGY: linear

tii)

MOLECULE TYPE: cDNA

(Xi)

SEQUENCE DESCRIPTION : SEQ ID NO: 143 0:

GAATTCGCGG
AGTTGTGTAT
TCAGAGTTAG
TAAGTTAGGG
CTCCCAGCTT
TGTATGGGGA
GCAAACACTC

CCGCGTCGAC GCTGTTCATG AGGAGACTTA ACCACAATTC AAAGTG TAG C
TTTAG CATT A TAATATTTGA TTGAGGCCCT GAGGTGTTAA TATCTCAATC
ATGTTCATGT CCTTTTTGAA TTTTTTAAAC ATTTTTCATA ATTTTTTTTT

60
120
180
240
300
360
373

AG CACATTG A GTGAAGTTCT CTGTGTAGAA CAATAC CTTC TGCTCTGCTT

TCACTGAGGG CTGGAAAAGG ACAGGCCTGT CCAGCTGTAC TGTCCCACTG

AGCTCAGGCT CTGGTGGAAG CAGGGGGCAT GGATGTCAAA CAACTGATGT
GAG

(2) INFORMATION FOR SEQ ID NO: 14 31:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 632 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1431:

GAATTCGGCC TTCATGGCCT ACTACTGATG AGAACATTAT CTGCATATGC CAAAAAATTT 6 0

TAAGCAAATG AAAGCTACCA ATTTAAAGTT ACGGAATCTA CCATTTTAAA GTTAATTGCT 12 0

TGTCAAGCTA TAACCACAAA AATAATGAAT TGATGAGAAA TACAATGAAG AGGCAATGTC 180

CATCTCAAAA TACTGCTTTT ACAAAAG C AG AATAAAAGCG AAAAGAAATG AAAATGTTAC 24 0

ACTACATTAA TCCTGGAATA AAAGAAGCCG AAATAAATGA GAGATGAGTT GGGATCAAGT 300

GGATTGAGGA GGCTGTGCTG TGTGCCAATG TTTCGTTTGC CTCAGACAGG TATCTCTTCG 360

TTATCAGAAG AGTTGCTTCA TTTCATCTGG GAGCAGAAAA CAG CAGGCAG CTGTTAACAG 420

ATAAGTTTAA CTTGCATCTG CAGTATTGCA TGTTAGGGAT AAGTGCTTAT TTTTAAGAGC 480

TGTGGAGTTC TTAAATATCA AC CATGGCAC TTTCTCCTGA CCCCTTCCCT AGGGGATTTC 54 0

AGGATTGAGA AATTTTTCCA TCGAGCCTTT TTAAAATTGT AGGACTTGTT CCTGTGGGCT 600

TCAGTGATGG GATAGTACAC TTTTCACTCG AG 632

{2) INFORMATION FOR SEQ ID NO: 1432:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 298 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii.) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1432:

GAATTCGGCC TTCATGGCCT ACTAATTTCC AAG AG CTAAA CTTTATACCG CCTGCAATAT 6 0

TTCCATTTAC TACCAGTTTT TTTCTGACCT AGTCAGATAT AAGAAGCCCC CTTACTGGAT 120

ACAAGACAGT TAATTATCAG ATCCAGTCTG ATCCTAGATC CAGTCTGATC CTAGACCCAG 180

TCCAGTTTCT GTTGTGACTT CCAAACCCAG TTTGGATCAG AAATTTGCTC AAAGAAACTA 24 0

GGAGAG CTCA AAACACAAAT ATGTGGAGCT TCTGAATCTG AGAGAGAACG AACTCGAG 298

U> INFORMATION FOR SEQ ID NO: 1433:

(i) SEQUENCE CHARACTERISTICS:

568

WO 98/45437

PCT/US98/06956

(A) LENGTH: 3 35 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1433:

GCGTGGTTTC ACCTTGTTGG CCAGGCTAGT CTTGAACTCC TGACCTCAGG TGATCCACCC 6 0

ACCTCGGCCT TCCAAAGTGC TGGGATTACA GGCATGAGCC ACCGCATCTG ACTGGTGCAC 120

TTTACTTTGA CCTGTCATAA ATCCCTTGGT TTGTTATTAC TAGTTTTTAC TTTAG AC AG C 180

AATTATCTTT CAAGGAAAAA TTTAAAAGGA AAAAATGTCT TATATTTACC CTCATGTTTA 24 0

CCATTCCCAG TGCTCTTTAT TTCTTTATGT CAATCCGGAT TTCAATTTGT TATCATACTG 3 00

TTTCTGCCTG AATAACAGTT TAACAGCAAC TCGAG 3 35

(2) INFORMATION FOR *EQ ID NO: 14 34:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 316 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii> MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1434:

GAATTCGGCC TTCATGGCCT AATGCTCTGT GTCACTGTCT CCCGGTGCTC AGCACAGACA 60

AGTTCAAGAC AGATTTTTAT GATCAATGCA ACGACGTGGG GCTCATGGCC TACCTCGGCA 120

CCATCACCAA AACGTGCAAC ACCATGAACC AGTTTGTGAA CAAGTTCAAT GTCCTCTACG 180

ACCGACAAGG CATCGG CAGG AG AATGCG CG GGCTCTTTTT CTGATGAGGG TAC TTGAAGG 24 0

GCTGATGGAC AGGGGTCAGG CAACTATCCC AAAGGGGAGG GCACTACACT TCCTTGAGAG 3 00

AAACCACTGT CTCGAG 316

(2) INFORMATION FOR SEQ ID NO: 1435:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 83 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1435':

GAATTCTAGA CCTCCCACCC TGTAGAACAT TCTCCTCACT TAGGAGATAG TCATATTTTC 60

AGGCTGCCTT TGAAACTGTG GGTACACAAA CAGCAGAGCG ATCTATTTCA GCAGTTGAAG 120

TTGTATTTGA GCCATTATTT CTTCCACTCT CTTTTTGGTT GAGTTTCTAG GAAGGAAAGG 180

GCTGAACTCC ATGACTGCTC ATATTACAGT GCTAAGTCCT CACAGCCATC CACTGTTTAT 24 0

ACACAAGAAG AAACTAGGCC CACCAAGAGT AAGCGCCTGC CTGAGGTCCG TGAGTGAGTA 300

AGGGCCAAAG GTGAGGTTGG GATCTGGCCC TTTCTCTTTT CTGGCCACCA CAGGG CACTA 360

CCTCCCATAC CCACACACTC GAG 383

(2) INFORMATION FOR SEQ ID NO: 143 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 03 base pairs

569

WO 98/45437

PCT/US98/06956

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1436:

GGAGAACTGC TAAGGTCCAC AACGTCGACA ATTGAAAGCT TTGCTGCACA AGAAAAACAA 60

ATGGAAGTTT GTGAAGTATG TGGAGCCTTT TTAATAGTAG GAGATGCCCA GTCCCGGGTA 120

GATGACCATT TGATGGGAAA ACAACACATG GGCTATGCCA AAATTAAAGC TACTGTAGAA 180

GAATTAAAAG AAAAG TTAAG GAAAAGAACC GAAGAACCTG ATCGTGATGA GCGTCTAAAA 240

AAGGAGAAGC AAGAAAGAGA AGAAAGAGAA AAAGAACGGG AGAGAGAAAG GAAAGAACTC 300

GAG 303

(2) INFORMATION FOR SEQ ID NO: 143 7:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 228 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS- double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1437:

GAATTCGGCC TTCATGGCCT AGACTTTTAC ACATTTTTAT TAG CTACCTG GAATTATTTT 60

TGTAACACGT TAAGTG TAAA TAAACAAATA ATGCTTTGCT TTTTGTTT T C TGGAATTATT 120

GTTGTATTTC TTTGCCAAAT GCATATATCT TCAGGTCTTT TTTTTATAAC CATATGCATA 180

CCAAGGCACC ATTCCATTGA CTTTCCAACT TCTGTCCCAA CCCTCGAG 228

(2) INFORMATION FOR SEQ ID NO: 1438:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 98 base pairs

(B) TYPE: nucleic acid
CO STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1438:

GTGAATTCCA GTCCCCACCC AGAAACCCGC AGCATGATTG TCTGCCTCCT TTTCATGATG 60

ATTTTATTGG CAAAGGAAGT TCAACTGGTA GACCAAACAG ATTCACCTTT ACTTAGTCTC 12 0

CTTGGACAGA CAAGCTCACT TTCATGGCAT CTTGTGGATA TTGTGTCGTA CCAGAGTGTG 18 0

CTAAG TTATT TC AG CAGCCA TTACCCGCCG TCCATCATCC TGGCAAAAGA ATCTTATGCT 24 0

GAATTAATCA TGAAGCTCCT AAAAGTGTCT GCGGGCCTTT CTATTCCTAC TGACAGCCAG 3 00

AAGCATCTTG ATG CAGTTCC AAAATGCCAA GCTTTTACTC ATCAGATGGT TCAATTCCTC 3 60

AGCACCCTGG AACAAAATGG AAAAATCACC TTAGCAGTCC TAGAACAGGA AATGTCTAAG 4 20

CTCTTAGACG ATATCATTGT CTTTAACCCG CCCGACATGG ACAGCCAGAC CCGCCACATG 480

GCCCTCAGCG GTCTCGAG 4 98

(2) INFORMATION FOR SEQ ID NO: 143 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 314 base pairs

(B) TYPE: nucleic acid

570

WO 98/45437

PCT7US98/06956

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii)

MOLECULE TYPE: cDNA

SEQUENCE DESCRIPTION: SEQ ID NO: 1439:

GAATTCGGCC
TGGTCTAACC
TTAATGCTCA
TTGTTAGTTT
GCTAGACATC
GG AAGTGGCT

TTCATGGCCT AGCAGGGAGA GGGGTTCTGT GCTCCTGAGA TTAGTTCAGA

ATTGTTCTAT ATGTGCATTT TAGTTAATAT TGTGTATTAA AGGATAAGTC

AAGTATG TTA AAAATAGATG TAGTAAATCA GTCCCTTTGT GAATGTCCTT

TTAGGAAGGC CTGTCCTCTG GGAGTGACCT TTATTAGTCC ACCCCTTGGA

CTGTACTTAG TCACGGGGAT GGTGGAAGAG GGAGAAGAGG AAGGGTGAAG
CGAG

60
120
180
240
300
314

(2) INFORMATION FOR SEQ ID NO: 144 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 424 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 144 0:

CCAGCCGTCT GCAGCTCCGG CCGCCACTTG CGCCTCTCCA GCCTCCGCAG GCCCAACCGC 60

CGCCAGCACC ATGGCCAGCA CCATTTCCGC CTACAAGGAG AAGATGAAGG AGCTGTCGGT 120

GCTGTCGCTC ATCTGCTCCT GCTT CTACAC ACAGCCGCAC CCCAATACCG TCTACCAGTA 180

CGGGGACATG GAGGTGAAGC AGCTGGACAA GCGGGCCTCA GGCCAGAGCT TCGAGGTCAT 24 0

CCTCAAGTCC CCTTCTGACC TGTCCCCAGA GAG C CCTATG CTCTCCTCCC CACCCAAGAA 300

GAAGGACACC TCCCTGGAGG AGCTGCAAAA GCGGCTGGAG GCAGCCGAGG AG CGG AGGAA 360

GACGCAGGAG GCGCAGGTGC TGAAGCAGCT GGCGGAGCGG CGCGAGCACG AGCGCGGGCT 420

CGAG 4 24

(2) INFORMATION FOR SEQ ID NO: 1441:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 346 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

ID) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1441:

GAATTCGGCC TTCATGGCCT ATAGGCCATG AAGGCCGGCC TTCATGGCCT AGTCAGGCTT 60

AAGTTTAATA AATAG CAAAT TG CATACAG A TATTTACAAT GATCGAAAGA CAAACAGAGG 120

TCCTATCCGT GCAGTCCCAA CAATAAAGAC AGGCATTGGC ATAAAGTGTT TATAAATTCT 180

TGGGTACAGC TG TTCTGAAA GTAAAGTTCA CTTTCAATCC TAAAAAAAGT CCGCTATTCC 24 0

TCCCTGGCTG CTCTGGACTG TCCTCATCCT CTTTAGCTGC TGTTGCGCCT TCCGCCACCG 300

ACGAGCTAAA CTCAGGCTGC AACAACAGCA GCGGCAGCAT CTCGAG 34 6

(2) INFORMATION FOR SEQ ID NO: 1442:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 591 base pairs
<B) TYPE: nucleic acid

571

WO 98/45437

PCT/US98/06956

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1442:

GAATTCGGCC TTCATGGCCT AGGCTTCCCT GTTCCCTCAG CCCCAGTCGA GAGGAAAGAG 60

AATCGGGCCA CTG CCAG AAA G AG AG TCAAG CAAACCTGGA AGGGCAAATC TGAGAGTGGG 12 0

AAGGC CAAAG GCCGAGGCCC AGATTTAGTA TTCACTAGCA GCGCCTTCGG GTAGCAGGAT 180

GATTCCTTTT CCTGCCTGTC TGCTGCTGGC TCTCTTCCCT AAGGTACAGG TTGG CAGG AC 24 0

CACCTCCGCC TACTTCTCCA CCATCCCTAG CATGCCAGCC CGTTCCCAGA TCAACCTGCC 300

AGTGGAGTCA GGCAGTGCAC TCCTGGAGCC AAGAGGGAAG GGCAGGGTAG AGAGGGTATG 360

TCCAGTAGCC TGGAGCTCCA TGGTGGCTTC ATGCCTCCCT TCTCCCAGCT CAGGTGGCCC 420

TGAGGGCTCC CTCGGAACAG TG C CTCAAAT CCTGACCCAA GGG CCAG CAT GGGGAAGAGA 480

TGGTTGCAGG CAAAATGCAC TTTATAGAGA TTTTCTATTG CTGGGAAGGT GTGTTTCTCC 54 0

CACAATTTGT TTGTGAATAT TCACTTGTTT TATAAATGTC TGACCTGTCC G 591

(2) INFORMATION FOR SEQ ID NO: 1443:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 52 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1443:

GAATTCGGCC TTCATGGCCT AGATTGAATT ACCTGCCTCG AGCTCCTGTC CTTAGGTGAT 60

CTGCCCGCCT TGGCCTCCCA AAGTG CTGGG ATTATAGGAG TGAGCCACCT GGCCCAGCTA 120

GCTTTTAAAG TTCTGCCAGC ATAGCCCCGG GATGGGGTGG GGGTAGACAG GGCCTTAGGA 180

CTTTCATTTT TAAAATGCTC ACTCCACAGT GAAGAAACAG GTGATGACTA TCCTGAATAT 24 0

TTGGGAAGCT GTGTCCTAGA ATTTTTGGCC TCAGTTCCAG AACCCACAGC TTCTTTACAA 3 00

CATGCTTCAA GCCTGGGACT G AGCTG CCAG TAAATAAACC CCTAGTAACC TTAATATGGG 3 60

TTAATAAGAT TAGGTGCCCG CTCTGCACGC TCCCCTGCCC CTCCTCGTCC GGGCACCTGT 4 20

TATGCTAGGC CAGCATGTTT GCAGCTTAGC CAGGGAAAAT CGTGGACCAA GACAGGGCTT 48 0

TTCATCCACG ACTGGCTAAA AAGATGGCTC TCAATAATAT CTCGAG 526

(2) INFORMATION FOR SEQ ID NO:1444:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 27 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1444:

GATTGAATTC TAGACCTACC TCTCTTTTTT TGTGGTCTCT CCTTCATTCT CTGTTCATTT 60

CTCCGTGAGA TTTTCTGATT AGTAGTTACC TTCAGCATGC CAGTTGACTT GCAAACCTAC 120

AATCCAACCT TTCTTCTACT TTGTCATCTG ACAACAGCCT GGTTTGTAGC TGATTCCAGG 180

ACTTCTTCAC TTGGGTGGCC ACTCTCATTA CCACAGAGTT CACTAGTCAT GGTGAACACA 24 0

CCAGTCTTTT ACACCTCCCT CACTCCCAAA CCACTCGAG 279

(2) INFORMATION FOR SEQ ID NO:1445:

572

WO 98/45437

PCT/US98/06956

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 644 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1445:

GAATTCGGTC TTCATGGCCT AGGGGAAGAA AGGCACCTTT CTCACAGGGT GGTGAGAGAG 60

AGGAAGGGGG ACGGGGAAAG CCCTTTATAA AAG CATCAGA TCGGCTGGGC ACAGTGGCTC 120

ACGCGTGTAA TCCCAGCACT TTGGGAGGCC GAGGCGGGTG GATCGCGGGG TCGGGGGTTT 180

GAGGCCGGCC TGGCCAATAT GGTGAGACCC CGTCTCTGCT GAAGATACAA AAATTGGCTG 24 0

GGCATGGTGG CGGGCACCTG TGGTCCCGGC TGCTTGGGAG GCTGAGGCGG GAGAATCGCT 3 00

TGAGCCCGGG AGGCAGAGGT TGCAGTGAGC TGAGATCGCG CTACTGCACT CCAGCCTGGG 3 60

CAACAGAGCG AGACTCCATC TCAAAAATAA AAGAAAGGCA TAAATATTAC ATTACCCTCT 4 20

GAATACTGTG GTTGTATACT TGAGTTTTTA TGTGTGTATA TATATGTGTA T AGG AG AG TA 4 80

AAAATAAAAT GAAATTAGGA TTTTGCAAGT TATAATCATA TAAAATTGAT TACC CTAAAT 54 0

ATATCATTAG GATATTATGT TATTTACATC TCTTATGCTA ATTCTAATTT TCTTTTATTG 600

TAGTAT AG TA GAATTGAGAT TTGNNAATGG AATTGGTCCT CGAG 644

(2) INFORMATION FOR SEQ ID NO: 144 6:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 756 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 144 6:

GAATTCGGCC TTCATGGCCT ACCTCACCCG GCCCGGACAC GGACAGGATT GACAGATTGA 60

TAGCTCTTTC TCGATTCCGT GGGTGGTGGT GCATGGCCGT TCTTAGTTGG TGGAGCGATT 120

TGTCTGGTTA ATTCCGATAA CGAACGAGAC TCTGGCATGC TAACTAGTTA CGCGACCCCC 180

GAGCGGTCGG CGTCCCCCAA CTTCTTAGAG GGACAAGTGG CGTTCAGCCA CCCGAGATTG 240

AG CAATAAC A GGTCTGTGAT GCCCTTAGAT GTCCGGGGCT GCACGCGCGC TACACTGACT 3 00

GGCTCAGCGT GTGCCTACCC TACGCCGGCA GGCG CGGGTA ACCCGTTGAA CCCCATTCGT 360

GATGGGGATC GGGGACTGCA ATTATTCCCC ATGAACGAGG AATTCCCAGT AAGTGCGGGT 4 20

CATAAGCTTG CGTTGATTAA GTCCCTGCCC TTTGTACACA CCAACCCGTC ACTGACTTTT 4 80

ACCGCAGCTG GAACTGTGCT CCAGGGCCTT TCCATCTTTT CCCCCACACT CCCTTTGACC 54 0

CTGTGTTGCC CTCAGAGGCC AAATTCTTGG GCTCAGGGAC TGGCTTTCGG CCTATTGGTG 600

GTGGAGCTGG GGTTCTGGCA AGGAATTTCA GGCAGCGCTT GGAGGCAATG TTCCCCGAGA 660

GCAGTTCACG GTGGTGATGT TGACTTATGA GCGGGAGGAA GTGCTTATGA ACTCTTTAGA 720

GAGG CTGAAT GGCCTCCCTT ACCTGGAACT CTCGAG 7 56

(2) INFORMATION FOR SEQ ID NO: 144 7:

<i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 59 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 144 7:

573

WO 98/45437

PCT/US98/06956

GAATTCGGCC TTCATGGCCT ACCTGCCTCG AGGTCACTGG GATCATCTGA ACAGAAGTGC 6 0

ACAGGCTACT TGTACAGAGA AAAAATTAAT ACTCAAAGGA AATCTTCATT TTTTAGATTG 12 0

ACTTTGGGAA TTTGAATTTT CAT CAGTG CA AATATAAATT TCTCTATCCT GCTCTGAGGC 180

TAATTG GTAC CATATTTTCC CTTTGTGTCT TGTGACTCTG CCACATCCCA TCTCATCCTG 24 0

GCCTCTGAGT CAAGAACCCA GTGAACTGAC TTTCTAGTTC TAGAAGTTCC GCTGCAAGGC 3 00

CAGGAAAGCT TGAGAAAGGT ATTGTGGAAG AAGCAAAGGT AGACCCCCAT TCACTCGAG 3 69

(2) INFORMATION FOR SEQ ID NO: 144 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 14 6 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 48:

GAATTCGGCC TTCATGGCCT AGGGAAAATA AGTTAATTCT AAATCAAATC TAAATATTAT 60
ACCTCATGCT ATGGTTTTAT TTTATTTCAG TGCTGCCGTT ACTTTTCCTC CCCAAAGCAA 12 0

TGTGTTTTCC AGCCACAACC CTCGAG 14 6

(2) INFORMATION FOR SEQ ID NO : 144 9 :

<i) SEQUENCE CHARACTERISTICS:

{A) LENGTH: 3 08 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 1449:

GAATTCGGCC TTCATGGCCT ACTTTTCAAA AGCAG CTTTG CTCTACTGAT TTGGGTAAAA 6 0

GCTTAGTTGC AGTTGGNTTG GGAGGAAATG GGAGCAGAAA ATTTGAGAGA GTGAGTGTAG 12 0

ACAACTCTTT CAAGGAATTT CGCTATAAAT GGGAGTAGAG ATCTGAAGAC TGAATAATTA 180

G CAAACTG AA AAGTGGGAAG ACGTAATTCT CTTATTATTT CATTTTTCTT AGTGAAATAA 24 0

GAGGTGAAGT TCTCTGAGTA ATAGGAGGGT CAAACAGGNG TTAGAAGTTC ACAAAGAAAG 3 00

GTCTCGAG 30 8

(2) INFORMATION FOR SEQ ID NO: 1450:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 545 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO t '14 50:

GAATTCGGCC AAAGAGG CCT AG CATGTTG T GGCTGTTCCA ATCGCTCCTG TTTGTCTTCT 6 0

GCTTTGGCCC AGGGAATGTA GTTTCACAAA GCAGCTTAAC CCCATTGATG GTGAACGGGA 120

TTCTGGGGGA GTCAGTAACT CTTCCCCTGG AGTTTCCTGC AGGAGAGAAG GTCAACTTCA 180

TCACTTGGCT TTTCAATGAA ACATCTCTTG CCTTCATAGT ACCCCATGAA ACCAAAAGT C 24 0

CAGAAATCCA CGTGACTAAT CCGAAACAGG GAAAGCGACT GAACTTCACC CAGTCCTACT 3 00

574

WO 98/45437

PCT/US98/06956

CCCTGCAACT CAGCAACCTG AAGATGGAAG ACACAGGCTC TTACAGAGCC CAGATATCCA
CAAAGAC CTC TGCAAAGCTG TCCAGTTACA CTCTGAGGAT ATTAAGACAA CTGAGGAACA
TACAAGTTAC CAATCACAGT CAGCTATTTC AGAATATGAC CTGTGAGCTC CATCTGACTT
GCTCTGTGGA GGATGCAGAT GACAATGTCT CATTCAGATG GGAGGCCTTG GGAAACACAC
TCGAG

360
420
480
540
545

(2) INFORMATION FOR SEQ ID NO: 1451:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH : 331 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

tii> MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 51:

GAATTCGGCC AAAGAGGCCT AC AG TAAG CA GATGAACTTG CTTGCTGTTC T CG AAGTG AG 6 0

GACTGAAGGG AACGAAAACT GGGGTGGGTT TTTGCGCTTC AAAAAGGGGA AGCGATGTAG 120

CCTCGTTTTT GGACTGATAA TAATGACCTT GGTAATGGCT TCTTACATCC TTTCTGGGGC 180

C CAC CAAGAG CTTCTGATCT CATCACCTTT CCATTACGGA GGCTTCCCCA GCAACCCCAG 24 0

CTTGATGGAC AGCGAAAACC CAAGTGACAC AAAGGAGCAT CACCACCAAT CCTCTGTAAA 3 00

TAATATTTCA TACATGAAGG GAACCCTCGA G 331

(2) INFORMATION FOR SEQ ID NO:1452:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 263 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 52:

GAATTCGGCC AAAGAGGGAA GGGAAAATTT CAAGT CAG AT AGAATTCTAT ATATACCATT 6 0

TCTTTGGAAC CTTCAGCCCT CAAGATTCCA ACATCATGAC CTCAGTTTCA ACACAGTTGT 120

CCTTAGTCCT CATGT CACTG CTTTTGGTGC TGCCTGTTGT GGAAGCAGTA GAAGCGTATA 180

TGCACGAAAA AGAAATGGAC AGATGTGACT TTGAAAGGCC TACTGAGTCA AACCTCACCC 24 0

TGAAAACCTT TGCAGCACTC GAG 263

(2) INFORMATION FOR SEQ ID NO: 14 53:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 558 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS; double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1453:

GAATTCGGCC AAAGAGGCCT AATTTTAAAG CCCTGCTAAC TTCAATGTCT AGGTCACCCA 60

TTTGTTTATT TTTATGGTCT TTTTTCATCC TGATXTTTGG TCATTTGGTC CCGTCTTATG 120

GCATACCTGG TAATATTTTA TTGAATCCTT AGTACTGTAC ATGAAAAATT GTAGAGGCCC 180

CAGTAGTTTT CTTTCTCTGA AGAGGAGTCA CCCTTTCCTT CACTAGACAG TTATGTTGGG 24 0

575

WO 98/45437

PCT/US98/069S6

GGTTATATAC CTTACTCCAA TCAAAGATTG AGCTGAGTCA GAACTCTAAG GGAGTTAAGT 3 00

TTTTGTGTCC TCTGGGGACC AGGGGTTCCA ACTAAGACTG TGATATTCAC CAGGATCCAA 360

TTTCCCGATG CCTCTTGAAC TCTTATTCTT ATCTTTTTAA CACATCAAGG CAGCTGGTTT 42 0

GCATTTTTCT TTCTGTTCAG CTTTTTAGCT TCATCCTTTG CAGCTTTAGA AATTGACAGT 4 80

TGTCTTACAG GGAAAAGTAG CTGTGTAACA AGCTCATGTC TCTGCCTCTC TTCCACTGAT 54 0

ATCTTAGCCC CGCAGGAG 558

(2) INFORMATION FOR SEQ ID NO:1454:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH; 328 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 54 :

GAATTCGGCC AAAGAGG CCT ACCTAAACCG TCGATTGAAT TC TAG AAATA CAATGATTTT 60

AAAAAAGATT TCCAAAGGCT TTTTCTTTTT TTCTTTTTTC TNGAGACAGG GTCTCACTCT 120

GTCGCCCAGG CTGGAGTGCA GTGACACAAT CTCGGCTCAC GGCAAGCTCC GCACTGCCCC 180

CTCAGGTTCA CGCCATTCCT CCGCCTCAGC CTCCCGAGCA GCCGGGACCA CAGG CACGCG 240

CCACCACGCC CAGCCAACTT TTACATTTTT AGTAGAGACG GGG CTTCACC ATGTTGGCCA 3 00

GGATGGTCTC GGTCTCTTCT GCCTCGAG 328

(2) INFORMATION FOR SEQ ID NO: 1455:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 81 base pairs

<B) TYPE: nucleic acid

(C> STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 55:

GAATTCGGCC AAAGAGGCCT ACTTGATGTC TGTGACCCAC ACNTATTCGC ACACTCCCTC 60

CCCTTTTGAA AATCCCT AAT AAAAACTTGC TGGTTTTTGC GGCTAGTGGG G CATCATGG A 120

ACCTACTGAC ATGTGATGTC TCCCCCGGAT GCCCGGCTTT AAAATTTCTC TCTTTTGTAC 180

TCTGTCCCTT AATTTCTCAA GCTGGCCGAT GCTTAGGGAA AATAGAAAAG AACCTAGGTG 240

AATATTGGGG CAGGCTCCCT GATGAAATGA TATATATTCT TAAAATAAAC TTTTCATCTT 3 00

TGCATATACG TTTATATGCC GAGTTTTCTC CAACCTTGTC TTACAGCACT TTGTATACTA 3 60

CATTCTAGCC ATACTAAACT CTTGCAGTTC CTGAGACATG TGCTGTATCC TATTTCTTCT 420

GGTCCTTTTC TCATTGATTA ACTACCTGGA G CATACTTTT AATTCAGTGT CAGCG CTCGA 4 80

G 481

(2) INFORMATION FOR SEQ ID NO: 1456:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 93 base pairs

IB) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO:1456:

576

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PCT/US98/06956

GAATTCGGCC AAAGAGGCCT ACTTCACCTT CAAGTCCCCT TTCTCAAGAA TCCTCTGTTC 6 0

TTTGCCCTCT AAAGTCTTGG TACATCTAGG ACCCAGGCAT CTTGCTTTCC AGCCACAAAG 12 0

AGACAGATGA AGATGCAGAA AGGAAATGTT CTCCTTATGT TTGGTCTACT ATTG CATTTA 180

GAAGCTGCAA CAAATTCCAA TGAGACTAGC ACCTCTGCCA ACACTGGATC CAGTGTGATC 24 0

TCCAGTGGAG CCAGCACAGC CACCAACTCT GGGTCCAGTG TGACCTCCAG TGGGGTCAGC 3 00

ACAGCCACCA TCTCAGGGTC CAGCGTGACC TCCAATGGGG TCAGCATAGT CACCAACTCT 3 60

GAGTTCCATA CAACCTCCAG TGGGATCAGC ACG 3 93

(2) INFORMATION FOR SEQ ID NO: 1457:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 266 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
(D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 57:

GAATTCGGCC AAAGAGGCCT AGTGTGTGTG TGTGTGTGTG TGTGTGTGTT TTATCTCCTT 60

CAACTCTGAC CACCTGGAAG TCAGC CTAAT CTCTGCCCTC GTGTTGATCT TTAATTCAAC 120

ATTTAATTAC CTATCTTGGT ATCCATATGA ATTTGATTGT TTTTTTGGCT TTTTTTGAAC 180

TCATAAAAGG TATCCAAGTT CCTGGAGGGC ATAGTGCCCA TCTCCTCCCA TCCACCAGTG 24 0

GACATTCTTT TCCAAAAGAC ACATGG 266

(2) INFORMATION FOR SEQ ID NO:l458:

(i) SEQUENCE CHARACTERISTICS t

(A) LENGTH: 292 base pairs

(B) TYPE: nucleic acid
<C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 58:

GAATTCGGCC AAAGAGGCCT AGGTTGTAGT TACTTTCAGA GTAGATACAG GGTT TTAGAT 60

CATTACAGTT TAAGTTTTCT GACCAATTAA AAAAACATAG AGAACAAAAG CATATTTGAC 120

CAAGCAACAA GCTTATAATT AATTTTTATT AGTTGATTGA TTAATGATGT ATTGCCTTTT 180

GCCCATATAT ACCCTGTGTA TCTATACTTG GAAGTGTTTA AGGTTGCCAT TGGTTGAAAA 24 0

CATAAGTGTC TCTGGCCATC AAAGTGATCT TGTTTACAGC AGTGCTCTCG AG 292

(2) INFORMATION FOR SEQ ID NO: 145 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 89 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1459:

GAATTCGGCC AAAGAGGCCT AGTTTTATGA GAGGGTTTCC ATTAAGAAGT TAATTGAAAT 60
TCTTTATTTA TGTAAAATGA AATTTCCAAT TAAATTATTT CACACAGCAT TTTTTCCCCT 120
TAATTTCATT AGTTTTTTTA TTTCTTGGCC GACCCAGGCC AGG AG CTTAG G GAAAATG AT 180

577

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PCT/US98/06956

GAGGCCTCTT TTACGCTGTA GTCCTGCAAA TGCTGTGTTT TATTCCCCCT CCCCTGCTCA
GCACTCACCC ACGACTGACA CATGGGGTAC ACACACACAC ATAGTCGAG

240
289

(2) INFORMATION FOR SEQ ID NO: 14 60:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 330 base pairs

(B) TYPE : nucleic acid

(C) STRANDEDNESS : double
(D> TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1460:

GAATTCGGCC AAAGAGG CCT ACACCTGCGT TGGAACATCT GATCCAGTGA TAGCACGTCA 60

CTAGGTGCCT TAATTAATAA AG CCAAAATA TCTTTCCACT AGCAAACTAA TCGTATTCAC 12 0

TTTTACTCTC CCATTTTTAA TTAATCTTTC CTATTTCATT TCACCCTCTC ATCTCTTTCC 180

TCTATTGGAT TATCTCAGGT ATCTAATCCA ATTCACTACT GTTTAATGAA TGTAATTGCA 24 0

ACCAGTCTGC AATTCCTAAG GTTTTGTTTC TTTGCTTTTT TCTTTTGTAG TCCATCTCTT 3 00

TGCTACACTC AAGCAGGTCT AGAATTCGAG 33 0

(2) INFORMATION FOR SEQ ID NO: 14 61:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 83 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1461:

GAATTCGGCC AAAGAGGCCT AGGGACAGTG ATTATAGGAC TCCACACATG CAACTGAATC 60

TAGCATTACT GACTTTAAAT TTTTTGAGCC TATCTAAAGG CCAGATG CT A TCAGCAGCTG 120

AACGGCATCT ACCAAAACCA GCTGCAAAGA TAGAAGCGGA ACAACTGGTT TGGTGGAGAG 180

ATTCGATAAC AACGAGTTGG GAAATAGGTA AAATAATAAC ATGGGGTAGA GGTTATGCTT 240

GTGTTTCTCC AGGCCAAAAC CAGCAGCTGA TTTGGATACC ATCAAGATAC CTGAAAACTT 3 00

ATCATCAGCC AGATGCCAAG GAAGAGATTT TGGGAGGAAC CCGAGGACCC CATGTTATTA 3 60

TTTTACCTAT TCCCCAACTC GAG 3 83

(2) INFORMATION FOR SEQ ID NO: 14 62:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 375 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1462:

GAATTCGGCC AAAGAGGCCT ACGATGACGT CACCGTCACC ACCGGCGTGA AGCGAGACAG 60

TGGTGAGGGC TTCTGGACTG GATGGAGGAC CTGAAGACAT GAGGTGGAGG CACAGGTAGA 12 0

AGAGAAGATT CTCACCATCG CTGATTCACA CAAAAGCATT TCTCCAAGTG GTTGCAGATG 180

ACATGATTTC CCAAAGTGTT AGAGCTGAAG TGTGTTTCCT TGTGTATATA TACTGTGGTT 24 0

CCTTTATCCC TTCATCTGTG GATAGACAGG TGCAACCGTG TGGTTCCCCA CGATATGATT 3 00

578

WO 98/45437

PCT/US98/06956

TCATTGTGGT TTTCTGTCTG AAGAGTATCC CAG TATGTAC CTGTGGAGCA GCTTCTTTAT
CCCTTCTTAC TCGAG

360
375

(2) INFORMATION FOR SEQ ID NO: 14 63:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 174 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1463:

GAATTTGGGC GGAGACACAA ATTCAAATCA TATCAACCTG GTAAAGAATT TGGATTTTAT 6 0

TTTGAGTGTG TTAGTGAGTA TTGCATGGCT TTGAGCAGAG AAAGGATGAT TTATATGTTT 12 0

AAAAGAGTG C TTTGCCTCTT ATATGTGGAA GAGATTGTAG GAGGAGGACT CGAG 174

(2) INFORMATION FOR SEQ ID NO: 1464:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 122 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double.

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO : 1464:

GAATTCGGCC AAAGAGGCCT AGTTGCGGTT TAAATTTCCA AATGTATGGC ATTTGCTTGT 60
TTTTTAAGTT GATTTCTAGT TTTATCACAT TGTGGTCAGA GAATG C TGAG AAAGAGCTCG 120
AG 122

(2) INFORMATION FOR SEQ ID NO: 1465:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 315 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1465:

GAATTCGGCC AAAGAGGCCT ACTTGAGCTT TTTTCATGTG TATATATTTA TGCTTCTTTT 6 0

CTAAAAAAAA TTGAGATGGA AATTCACATA ACAGAATTAA CTAAAGCATA CATTTCATTG 120

GTATTTACTA CATTCACAAT GTTGTGCAAT CATTACCTCT CTCCAG ITCT AAACATTTCA 180

TCACCCCAAA AGGAACCCCT AAGCGGTCAC TCCCCACTCC ACTGTCTCCC ACAGCCCCTG 24 0

GCAACCAGCA GTCTGCTTTG TGTCTCAATG GATTTACCTA CTCTTGATAG CTCTACAAAT 3 00

GGAACAATAC TCGAG 315

(2) INFORMATION FOR SEQ ID NO: 1466:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 175 base pairs

(B) TYPE: nucleic acid

579

WO 98/45437

PCT/US98/06956

CO STRANDEDNESS: double
(D) TOPOLOGY; linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION; SEQ ID NO: 14 66:

GAATTCGGCC AAAGAGGCCT AGGTAAGAGA AACGACCAAT TCTACCAGTT AT TCTAC AAT 60
GTGGGTTTTC ACTGCTCTGT TCACATGCCT T ATT C AG ACT TCTTGTGGTG GTCAATTGCT 12 0

AGATGGTCTG TTGGAATTAT CTGCTGTCAT ACATCCAAAA AGGTCTCACA GAGAG 175

(2) INFORMATION FOR SEQ ID NO: 146 7:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 350 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 67:

GAATTCGGCC AAAGAGGCCT AGAAGGACAC CTCCATCCAT TCCACGCAGT TGCTCAAAGC 60

AGAAATTTTC AGTGCAAGTC TTGATGCTGC GCCGTCCCCC ACTCCCTACA TCAGAACGCA 120

TCCCTCATCT GGACTCCAGC GGTGGCTTCT TGATGCTGCG CGGTCCCCCA CTCCCTACAT 180

CAGAATGCAT CCCGCATCCA GACTCCAGCG GTGGTGCTCT ACCTGCACGC TGTTGCCAAG 24 0

TCCAAGCTAC CATACTCCTG CCTGAGCTAT GACAACAGCC TCCTCACTGA TCTCCCCTTT 300

CTTCCCTTTG CCTCCTCCAG CTCATTTTTC ACAGTGTAGA ATGACTCGAG 350

(2) INFORMATION FOR SEQ ID NO: 1468:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 419 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 146 8:

GAATTCGGCC AAAGAGGCCT ACTATACTAA AATTCTGTGC AAAAAGATGC TTGAAATTAT 60

TGTAGAGACT GAATCTTTGC TGCTTGTTAT AAATATTGCA GGGCATAAAC CTTCCATTCA 12 0

T AGGTT CATC AGCTTTTATG ATTGGGAGTG ACAGGGAGGC AG CATTG CAG TCCTTAGTGC 180

TAGGTGTGGT CTAGAATTTA CCCTGTATTT AAGTCACTTT GGAATAGAAG TTTTTTTTCT 24 0

CGGACAGGAT ACACTATATA TTTTTAAATC TCCTCCCATA GTCGTAGTGC AGAGATATAA 3 00

ATAGAAGTAC AGGTAAGAGA TGTCTTCTGC CTTTCAAACC CTTCCTAAGT TTGTGTGCTG 3 60

CTTTAACTTT ATTCACATAG AGCAGTCTGT TTTATTACTC AGGATATGGG CCACTCGAG 419

(2) INFORMATION FOR SEQ ID NO: 1469:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 612 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

580

WO 98/45437

PCT/US98/06956

(XX) SEQUENCE DESCRIPTION : SEQ ID NO: 146 9:

GAATTCGGCC AAAGAGCGAT GGGGACAAAG GCGCAAGTCG AGAGGAAACT GTTGTGCCTC 6 0

TTCATATTGG CGATCCTGTT GTGCTCCCTG GCATTGGGCA GTGTTACAGT GCACTCTTCT 120

GAACCTGAAG TCAGAATTCC TGAGAATAAT CCTGTGAAGT TGTCCTGTGC CTACTCGGGC 18 0

TTTTCTTCTC CCCGTGTGGA GTGGAAGTTT G AC CAAG GAG ACACCACCAG ACTCGTTTGC 24 0

TATAATAACA AG AT C AC AG C TTCCTATGAG GACCGGGTGA CCTTCTTGCC AACTGGTATC 3 00

ACCTTCAAGT CCGTGACACG GGAAGACACT GGGACATACA CTTGTATGGT CTCTGAGGAA 3 60

GGCGGCAACA GCTATGGGGA GGTCAAGGTC AAGCTCATCG TGCTTGTGCC TCCATCCAAG 42 0

CCTACAGTTA ACATCCCCTC CTCTGCCACC ATTGGGAACC GGGCAGTGCT GACATGCTCA 4 80

GAACAAGATG GTTCCCCACC TTCTGAATAC ACCTGGTTCA AAGATGGGAT AGTGATGCCT 54 0

ACGAATCCCA AAAG CACCCG TGCCTTCAGC AACTCTTCCT ATGTCCTGAA TCCCACAACA 600

GGCGCACTCG AG 612

<2) INFORMATION FOR SEQ ID NO: 14 70:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 220 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 70:

GAAAAGCCAA GACTTTAACT TTCATTACAT ATCTAATAGT TGATATCACC AGTTACCATT 60

TTGAATTTTG TATAGTACTA GGTTAGAACA TTG CTTAATC CTTTTAAAAA AAATG CATTT 120

ACGTAGAACT CGAGCAGGAT GTTTGGCCCC GATGTTTTTT CTTCATACTC TTCTGTCGCC 180

TCCTCCCATT TCTGCACAGT TCTCACCCAC TACTCTCGAG 220

(2) INFORMATION FOR SEQ ID NO: 1471:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 34 9 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1471:

GAATTCGGCC AAAGAGGCCT AGGGCATCAT GCAGACACAT CTGTTAAAGC AGGAAAAAAA 6 0

AAACCATGTG GAAGATTAAG CTAGGCAGAG TGCCTGAAAA GCCCTCTGCA ATAAGTTGAG 120

CTGGAAAAAC CTCCATATCT AAAGATGCTT TAATCATCTC AAGAACACCA ACAACATTTT 180

CTATTATAAT ATAACTATGA TAGATGTGAA TCTACCTCTT GGATTAAGGC AATAATTTTA 24 0

TAGCTATCAA ATTTTCACAG ACACCATTTT CACTACTCTG AGTTGCATCT CTAACAAGCT 3 00

TCTTTAGCCT CTGCCTACAG ATTTCAGTGA CAAAG CCATT CAGCTCGAG 34 9

(2) INFORMATION FOR SEQ ID NO: 14 72:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 310 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

581

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PCT/US98/06956

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1472:

GAATT CGGCC AAAGAGGCCT ACAACAAACC ATTCTTCAGC ACCTTTGCAA AAACATCTAT 6 0

GTTTGTTTTG TACCTTTTGG G CTTTATTAT TTGGAAGCCA TGGAGACAAC AGTGTACAAG 120

AGGACTTCGC GGAAAGCATG CTGCTTTTTT TGCAGATGCT GAAGGTTACT TTGCTGCTTG 180

CACAACAGAT ACAACTATGA ATAGTTCTTT GAGTGAACCT CTGTATGTGC CTGTGAAATT 24 0

CCATGATCTT C C AAGTG AAA AACCTGAGAG CACAAACATT GATACTGAAA AAACCCCCGC 3 00

GGTACTCGAG 310

(2) INFORMATION FOR SEQ ID NO: 1473:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 2 97 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1473:

GAATTCGGCC TTCATGGCCT ACAACTTTAA GATTAGCTAC TTTGAATAAT CTCAGTAGGT 6 0

TCTGGGGCAC AGGAGCTGCC CCTCTTGGTC TGAGATTTGG CCATGGGGTG ATTAGGACAG 120

GTATAGTGGC ACAGAGTGTA AAAACCCCAT AATGGTGTGG ATT CTGG ATT GCTTAGTTTG 180

CATTTGACAA GTGCATGCCT GGGAGGAGGA CTCCTCTTAG TAAAGAGGAT GGGAGGCAAG 240

AAGAGAGGCC AGAGGCCAAG ACAAGGTAAC TTAGG CATAG CATCAGGTTG TCTCGAG 297

(2) INFORMATION FOR SEQ ID NO: 1474:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 510 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 74:

GAATTCGGCC TTCATGGCCT AAAAAAGTAT GCAACACTCA GTTTATT TAA TACTTACAAG 6 0

GGGAAATCAT TAGAAACACA GAAAACCACA GTTGCAGCTC GACATGGATT ACAGAGTCTT 120

GGAAAAGTCG GTATTTCACG GCGTATGCCT CCACCTGCTA ACCTCCCAAG TCTTAAAG CA 180

GAAAACAAAG GCAATGATCC TAATGTAAAC ATTGTACCTA AAGATGG CAC AGGGTGGGCA 24 0

TCAAAACAAG AGTAACATGA AGAAGAAAAA ACAC CAGAAG TGCCACCAGC ACAGCCAAAA 300

CCTGGGGTTG CAGCTCCCCC AGAAGTAGCA CCTGCTCCCA AATCATGGGC CAGTAACAAG 36 0

CAAGGTGGGC AAGGAGATGG AAT CCAAGTG AATAGTCAGT TTCAGCAAGA ATTTCCCAGC 420

CTGCAGGCAG CTGGGGATCA GGAAAAAAAA GAAAAGGAAA CAAATGATGA CAACTATGGA 4 80

CCTGGACCCA GTTTACGTCC ACCACTCGAG 510

(2) INFORMATION FOR SEQ ID NO: 1475:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 00 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

582

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PCT/US98/06956

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1475 r

GAATTCGGCC TTCATGGCCT AATCCATTCA TTTGATGGAC ATTTTCTAAG TACCTGTGAG 6 0

CCAGGTGCTG CCATTTCAAA GTCTCTTCTT ACCACGCTCC TCAGTGGCTA G ACATTTT C A 12 0

CGTGGCCAGA AAGTCCCGAC TCTTGCTGGG CGTCCCTGGA CAAGTTGCCT TCCTCCTCTG 180

AGCTTGGCGC TCCCCATCTG TATAGTGGAG ACCCTTGGCC CCCCTCTGTA CGGAAGGGCC 24 0

GATGCGAAGC TGCAGTTAAA AAAGGCTCAC ATGCTCCTAG CCTTGTGCAG TCAGGAGGGG 3 00

AGACCAGGAC AGTTGGAAAT TATGATTGCA AATGG CTTTG CATTTTAGAT CATTCGTGTG 3 60

TGTGGATCAG AGAAACGCAC AAGTTCCCTG GCATCTCGAG 4 00

(2) INFORMATION FOR SEQ ID NO: 14 76:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 46 5 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 14 76:

GAATTCGGCC TTCATGGCCT ACCACATTTT GTCAG CAG AG AGCCTTTTAA ACTTGGATTC 60

CAACTTCCTG TTGTCTAAAC GGAACCCTCC GAACGTAGGA CTTATAGGGG AAGCTGCTGT 120

GCATGTCAAA AAAACTACTA ATCAGAATGA GCTTTGTCAT CCAGAGCCAG AACTGCTGCA 18 0

GAAATTTTTA TAATTTTGCA ACTTCTTTTT TTACAAGGAA CTTTTGTGCT ACTACACATC 24 0

AGGACTTTTG AAGCATCCAA TAAATCCATT TAATAAGTAT GAGCATGTGT CTGAGTGGAC 3 00

AAGAAAGTGA AACCATCCAT G CTACATTGG ATAATTTTTC CTCCCCCAGA CTGGACAGGG 360

AATCTCAGCT TTCAAAACAG AG TAAC CTGG CTCCACTTAC AAAGCTGCAC AGGCATTAAA 420

GATCGTGCTG CCTTTGTTAG GCAGATTTGG AGGGGAGAGC TCGAG 46 5

(2) INFORMATION FOR SEQ ID NO: 1477:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 377 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1477:

GAATTCGGCC AAAGAGGCCT ACATGTAGCT AT CCTAAGAC GTATTTTATT TTGAGCCACT 60

TTCTCAGAGG GAATTGGGTG GGTGTGGTCG TAAGAACACC TAGAAAATAG GGGTGAAACC 12 0

TTTATGGGGC CAGGGGAGCC ATGGCAGAGG GTGGAGTGGG GGATAGAAGC CTTCAGACTC 18 0

CTCCGCCCCA GCCACTCTGC ACCTGGGGCC TTTCAGCTGT TAAAATGAAA AG CCAATTAT 24 0

CTTCTGTAAA TGAGGGAAAA AAAGAAGGAA TAAAAGTGTC TATTATGTAT GCTGATATGC 3 00

ATAACACTTC AAATAAAAGG ATATATAAGC ACTTGACAAA TTGAGGGAGA AGGAGG GGAG 36 0

AGTGCTGGGC GCTCGAG 377

(2) INFORMATION FOR SEQ ID NO: 14 78:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 2 80 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

583

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PCT/US98/06956

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID N0:1478:

GAATTCGGCC AAAGAGGCCT AGAGATTCAG TTTATTCTAT ACTCAGACTT TGGTATCCCC 6 0

TTAGATGCCC ATGTCAAAAA TGAGAAAGTT GGTGACATGG TATGGCATTT TATTGCTTTT 120

TGTTTGTTTT CCATTGCTAC TTTCACTCAA ATTCCAAGGA AATCACAGAA GAAGGGCTTT 18 0

TGGTGACCTA AAAGTAGAAA TGAAAGCAAC AAAATG CAT T CTGTCCAGCA GTACACTGAA 24 0

GACAAAAAAT GTAGTTGAAA AGTCTCAGGG AGCGCTCGAG 280

(2) INFORMATION FOR SEQ ID NO: 14 79:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 91 base pairs

(B) TYPE; nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 79:

GAATTCGGCC AAAGAGGCCT AATTTGCTTT GCCCAGTAGT TGGAAAGTGA ACTCGACTCG 60

TGATGGTTCT CCTGTCACTT TGGTTGATAG CAGCCGCTCT GGTAGAGGTT AGGACTTCAG 120

CTGATGGACA AGCTGGTAAT GAAGAAATGG TG CAAATAG A TTTACCAATA AAGAGATATA 180

GAGAGTATGA GCTGGTGACT CCAGTCAGCA CAAAT CTAGA AGGACGCTAT CTCTCCCATA 240

CTCTTTCTGC GAGTCACAAA AAGAGGTCAG CGAGGGACGT GTCTTCCAAC CCTG AG CAGT 3 00

TGTTCTTTAA CATCACGGCA TTTGGAAAAG ATTTTCATCT GCGACTAAAG CCCAACACTC 360

AACTAGTAGC TCCTGGGGCT GTTGTGGAGT GGCATGAGAC ATCTCTGGTG CCTGGGAATA 420

TAACCGATCC CATTAACAAC CATCAACCAG GAAGTGCTAC GTATAGAATC CGGAAAACAG 4 80

AGCCACTCGA G 4 91

(2) INFORMATION FOR SEQ ID NO: 148 0:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 523 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1480:

GAATTCGGCC AAAGAGGCCT AATTCATTCA GTCGTCATGA GTTGAGTGCT TACTACATGC 60

AAGGCACTCT G CTAGTT ATA TTCTAATAAT GCAGAGATAA TTAGACATGG TTCCCGCCCT 12 0

CAAGAAGCTC ACAAAAGTAT TCAGGAAATA ATGCAGACTA GTGATTTTGC TATAAAATTA 180

TTTTTGAAGG AAGCAGACAC AGCAGTATTT ACCTGTAGGT GGAGCAAGTA ATAAGCCATG 24 0

CTGTGCAATA TATACATAAA GCTTCTGCTT CTCATGGGAA T TTAGTTAC A GTGCTTGGAA 300

TGAGAAGGGG AAGGAAAGAA TTAACAAATG CCAAGATTTC TGGAGCAGAT TG TACAGCTG 36 0

TGACTTTGGA AAACAGAAAG TAAGACCCTC AGAAAACCAA TGAAGTCTAA GAGAAATAAA 42 0

ATT TAGTGGA CAGGTATGAA AAGTGTAATT GCGCCTAACT AC CAGATGGA GAC CTTCAGA 4 80

ATGGGCTATC CTTAGAGTCT AGTACATCAA GAGACCCCTC GAG 523

(2) INFORMATION FOR SEQ ID NO:1481:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 104 base pairs

(B) TYPE: nucleic acid

584

WO 98/45437

PCT/US98/06956

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1481:

GAATTCGGCC AAAGAGGCCT AAAAAAAAAA AAAAAAGAAG ATATAAGCTA CTAGTATCAA
AAATGAAAGA GGGGCTGTTT CTACTGATCC TG CAG AC AC T CGAG

60
104

(2) INFORMATION FOR SEQ ID NO:1482:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 337 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TCT'OLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1482:

GAATTCGGCC AAAGAGGCCT AAACTGAACT AAGAGATGCA CCTGAGAAAA CCTTGGCTTG 6 0

CATGGGTTTG GCAATACATC AGGTGTTAAC TAAGG AC CTT GAAAGGCATG CAGCTGAGTT 120

ACAAG CCCAG GAAGGATTGT CTAATGATGG AGAAACAATG GTAAATGTGC CACATATTCA 180

TG CAAGGTG A GGAATTTGAT GTATTAAAGT ATTACTTAGA ATGGGACATT GAAGGC CATT 24 0

TAAGAATGAA NACG CTCATT TTATAAAAAT GAGGAAATCA GTAAAAAGGA CATGAGTTCC 300

TTGCCATCTC ATTGATCATC ACACTGAACA ACTCGAG 33 7

(2) INFORMATION FOR SEQ ID NO:1483:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 168 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 83:

CGATTGAATT CTAGACCTGC CTCGAGAGCG CGCTGTTGAA TACCCAGTAT GATGGTCCTT 60
AGCCTTCTTA GACCTTTCCT GTACCACTAC CTCTATGCCT TTTGCCAAGT CCAAGTGTTC 12 0

ACCAGAAATG GAACTGATGC CAGAAAGACT ACAGCAACAA TACTCGAG 168

(2) INFORMATION FOR SEQ ID NO : 1484 :

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 478 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1484:

GAATTCGGCC AAAGAGGCCT AGCAACCGCG CCTGGCTGCC TTTTCATTTT TAAAAACGTC 60

585

WO 98/45437

PCT/US98/06956

AGTGTCGCTC CCACACAACA TGCAAACCCT CCTGCCGAGC TGCGACCTTC GCCTGTCACG 120

GAACCTGGTG CTGAGTGTGG TG AG AG TGAA TCCTGCAGCA CGTGGCGCAC TGTCGGCCTC 180

TTTCATGTTT AGCTTTTGAT TGTGCTTATT GTCCATTTGT ATTTCTTCTT CTAAGTGTCT 24 0

GTTCAAGACT TTTCCGTCTT GGCTGGAGGT GGGAGGTGCC TGCTCCTGTG TTTTCTGGCA 3 00

TCTTTCTCTG CTGTCTTTGT GTGTCTGCAC TCAGGGAGTT TCCCTGGGGT GTGTGCCTAG 3 60

AGAGGTGCTG GTTGTACATT TCAACGTAGG GACAGATTCC CAGCGTGTCT TTAAAGGAGC 420

TGTGCCGCTG TGTGCTCACT TGACTCGCCG GCGTTCTTGT TTCTCCAGGC CTCTCGAG 4 78

(2) INFORMATION FOR SEQ ID NO: 1485:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 307 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 85:

GAATTCGGCC AAAGAGGCCT ACACACTGCA AG AACAGAG C CAAGAACCTA CCATGTACCC 60

TTTACTTGGA TTTAT CATTA. CTGTTTTGCA CATTTG CTTT ATCATTCTTG TTATATTTAC 120

ATATAGTTCC TTCCCCTTGG ATTATTTGAG AACAAACTGC AGAACTCACA CCTCTTTCCC 180

CGAAGAACTA GGCATTAGCA CATTACAAGA ATACGATGAT' AGAGATCAGA AGTTAAATGC 24 0

TGATGAGATA TTCCTGTCTA ATCCACGAAC CTTATTTCAT TGTCATCAGT TGTCCCAACA 300

GCTCGAG 3 07

(2) INFORMATION FOR SEQ ID NO:14B6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 579 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

Ui) SEQUENCE DESCRIPTION: SEQ ID NO: 14 86:

GAATTCGGCC AAAGATTGCT GTCCTTCAAC GTGTT CATTA TGAAGTTATT AGTAATACTT 60

TTGTTTTCTG GACTTATAAC TGGTTTTAGA AGTGACTCTT CCTCTAGTTT GCCACCTAAG 120

T TACT ACTAG TATCCTTTGA TGGCTTCAGA GCTGATTATC TGAAGAACTA TGAATTT CCT 180

CATCTCCAGA ATTTTATCAA AGAAGGTGTT TTGGTAGAGC ATGTTAAAAA TGTTTTTATC 24 0

ACAAAAACAT TTCCAAACCA CTACAGTATT GTGACAGGCT TGTATGAAGA AAGCCATGGC 3 00

ATTGTGGCTA ATTCCATGTA TGATGCAGTC ACAAAGAAAC ACTTTTCTGA CTCTAATGAC 3 60

AAGGATCCTT TTTGGTGGAA TGAGGCAGTA CCTATTTGGG TGACCAATCA GCTTCAGGAA 4 20

AACAGATCAA GTGCTGCTGC TATGTGGCCT GGTACTGATG TACCCATTCA GGATACCATC 48 0

TCTTCCTATT TTATGAATTA CAACTCCTCA GTGT CATTTG AGGAAAGACT AAATAATATT 54 0

ACTATGTGGC TAAACAATTC GAACCCACCA GTCCTCGAG 579

(2) INFORMATION FOR SEQ ID NO: 1487:

<i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 52 base pairs

(B ) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

586

WO 98/45437

PCT7US98/06956

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 87:

GAATTCGGCC AAAGAGGCCT AGATTGAATT CTAGACCTGC CTCGAGAGTC ACGCTTAGTT 60

TGCCATTGTG CCAG C TAG TG ATATTGCTGA TGTTTTTTGT GGGTGTTCTT TT AG CAAAAC 120

GTGAATGAAT GCATGTTTAC AGGGATGCTC TGGACTGGAG GATGGTGAAA TCCATCGTGG 180

TTGTCCCTCT CCCTGAATGT CCTTTTGTAG CCAGGGCATC TTTCCAATAT GAATTATTAA 24 0

GCCTTAACTT ACATTTTTGC ATAACTTATA ACTCTCCATT ATATATTTGG TTACATTTCT 3 00

TAGATGTTTT CAACATTCTT TAT TAAAGTT ATTTTATCAG CATCCGCTCG AG 3 52

(2) INFORMATION FOR SEQ ID NO: 14 88:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 422 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 88:

GAATTCGGCC AAAGAGGCCT ACAAATGGGC AGAAGTGAAA CAGTCTTGTG AGATACCTGT 60

TTTTTAAAAC TCCATTTTAG AAAAGGAATT AACTAGGACT TTATATCTCT TCGTT CAATA 120

TAATTTTAAA GAAGAATTGT TGAAAAGTAG ATATGTTTTG CCATTTGCTG AGAATATTTT 180

GTACGTTAGC TTGTCTCTTA CAAAAACTAA ATGTGTTCCT ACTT CTGATA ATGTATGTCA 240

ATTTAAAATT TGGAATGGCC AAGATAAGTT GCTCTGCATC TGTCCTTCAT ATGGCTCCTG 300

AG CACAG CTC AGTGACTGGC CCTTGCAGTG CTTCTACCGT TGTAATGGGT AAAACCAGGG 360

GAAACTGCCT TGCTCTTGAG CTTG AG CAGG TTAATCAAAA GGATAGAGCT TCCACTCTCG 420

AG 422

(2) INFORMATION FOR SEQ ID NO: 1489:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 93 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1489:

GAATTCGGCC AAAGAGGCCT AGAGAAAGAG AGAAAGAAAG GAGGGAAGGA AAGGAAGGAA 60

GGAAGGAAAG AAGGAAAGAA GGAAAGAGAG GAGACTGAAG GGC CAAGGAG GGCATACAAT 120

G G AAGATG AG AGCTGTGCTC CCGGGAGGCT TGTACTCATC AAGAAAGAAA GGAGAAAGAG 180

GGGGAAGAAA AGAAAAAAAA AGAATAAAGA AAGGAGAGAT GAAGGAATAA AGGAAAAAAA 240

GTAGAAAGGA AAGAAGGAGA AGGGAGAGAA GAAAGTAGGA AGGAGAACTC GAG 293

(2) INFORMATION FOR SEQ ID NO: 14 90:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 250 base pairs

(B) TYPE: nucleic acid
(C> STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1490:

587

WO 98/45437

PCTYUS98/06956

GAATTCGGCC AAAGAGGCCT AGTGCAACTA CAGATAAGTA AACTTCGACT GGGTTTAGTA 6 0

ACACCTGTCT TTAATATTTG TCAGTGTACC TACATTGATA ACATTGACCT TTGGAAAAAT 12 0

TGGACTTGTA TTGTGTTATT TCTCTAGCAT ATTAGTCCTA AAAAAGTGTG AGTAATAGGA 180

GATGGAGAGG TGTTTGTGGA TTGTCATTCT GTGGTTCCTA CAGCATTCAA GTTGCGTCCG 24 0

TACGCTCGAG 250

(2) INFORMATION FOR SEQ ID NO: 14 91:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 435 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: CDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 14 91 :

GAATTCGGCC TTCATGGCCT AATTCTTAGA AATAAAG CCA CTATCATG CA GGTTATTTAC 60

AAGTAAAAAC ATGGAGTCAG CCCAGTAGAG AAACGTTCAA ATAGTGTGGC TCCTGCTCTG 120

CCACGTTCTG TTTATGACTT TGGATATTTT ATTTATCCTT TCTGGGGTAG TTTTTCAACT 180

TTAAGGTCCT AATAAACTTT TAGATTTTAT GACCTGTCCT CTTTAGCCCT GTAAGATTTA 240

AATATTATAA AGAACCTGAT TTCAAAGACA CTGGTAAACT TGGACAACTA AACAAGTCCA 3 00

AGTATGG TAC TTATTTGTGT GTGTGCATAT ATTAACCTTA TGCATATGCT GTTTTCACAC 3 60

CTATTTAAAC TGTTTTTGAA AAACGTATAT ATCAGTTTTT GGAAAACAGA AGAAGATTTT 4 20

AAACGGCTAC TCGAG 43 5

(2) INFORMATION FOR SEQ ID NO: 14 92:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 360 base pairs

<B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 92:

GCGATTGAAT ACATGTTCAA TAAGGACAAT GGACAGG C AC CTTTTACCAT CACTCCTGTG 6 0

TTTTCAGATT TTCCAGTCCA TGGGATGGAG CCCATGAACA ATGCCACCAA AGGCTGTGAC 12 0

GAGT CTGTGG ATGAGGTCAC AGCACCATGT AGCTGCCAAG ACTGCTCTAT TGTCTGTGGC 180

CCCAAGCCCC AGCCCCCACC TCCTCCTGCT CCCTGGACGA TCCTTGGCTT GGACGCCATG 24 0

TATGTCATCA TGTGGATCAC CTACATGGCG TTTTTGCTTG TGTTTTTTGG AGCATTTTTT 300

GCAGTGTGGT GCTACAGAAA ACGGTATTTT GTCTCCGAGT ACACTCCCAT CGATCTCGAG 360

(2) INFORMATION FOR SEQ ID NO:1493:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 271 base pairs

(B> TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1493:

588

WO 98/45437

PCT/US98/06956

GAATTCGGCC TTCATGGCCT AAGCAGACAA T ATAG TAG T A ATTTAAATTT TTGTTTCCTG 6 0

ACTTTCTGTA GTCCCTAAAC AAACAACAAA AAATC CTAGT AATCTTAAAC TTTTACATTA 120

AT AG AG AT C C AAGAGAAAAT AAGCCATTTT TCACCATTGT GGACCCAAAT AAATCATAGA 180

CATGG T ATT A AGAAGCCCTT TTCAGTCTGG TTGCAGTATT ATTTTCCTAC CTTTCTTTTT 24 0

CCTGTTCCCT GCTGTATGCC CACAGCTCGA G 2 71

(2) INFORMATION FOR SEQ ID NO: 14 94:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 310 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY : linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID N0:1494:

GAATTCGGCC TTCATGGCCT AATGGGTCAG AAATTTGGGC CTGGCTAAGT GGATCCTCCA 60

CCCCAGGGTC TCTCACAAGG CTGCAATCAA AGGGCTGACT AGGACTTGGA ATCTCATTTG 12 0

AAAGTTAGAT TGGGGAAGGA TCTGCTTCCA AG CT C ACT CA GTAGTTACTG G CAGG ATTAG 18 0

GTTTCTCCAA GGTCGTTGGA CTAAGGGTCT CAGTTCCTCA CTGACAGTTG GCCTGAGGCT 24 0

GCCTTCAGTT TCTTGCCATG TGGGCCTCCC CAGCATAACT GTTTACTTCA TCAAAACAAA 3 00

CAAACTCGAG 310

(2) INFORMATION FOR SEQ ID NO:149S:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 13 8 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 95:

GAATTCGGCC AAAGAGGCCT ACGTCGATTG AATTCTAGAC CTGCCTCAGC TCTAATTATG 6 0

GTTCATGTTA GATTGTCTGC CCTTCCTCTT CCTCTTCTCT TTTGGGGAAA GAT AAT AG C A 12 0

CTTAATAACG CCCTCGAG 13 8

(2) INFORMATION FOR SEQ ID NO: 1496:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 102 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 96:

GAATTCGGCC AAAGAGGCCT ACAAAATTGT TCCTTTTACG TACGACAGAC TTCTGAAATG 60
GTAGTAGTAG TAGTGCCCTT TTTTTTTCTC TTTTTAGCCC AG 102

(2) INFORMATION FOR SEQ ID NO: 1497:

(i) SEQUENCE CHARACTERISTICS:

589

WO 98/45437

PCT/US98/06956

(A) LENGTH: 483 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 97:

GAATTCGGCC AAAGAGGCCT ATTTGTTTCT TTGTACTGCC TAACTTTAGA AAGACCTGNA 6 0

ANCGGTANCA TGAAAACATT TTTAGAGAGA ATTACCAGGC ATTTTTGGTA GAATGAGTGT 12 0

TTAATGGAAC AGT CCAGAGA ACT CATCAAA GATGTTTATT AAAACG CGCA GACCTGCTCC 180

AATTAAGGGC CCAGTCAGTG GTGTTAACAG TGAAGGGACT GTTCCAGAGG CGTGCTGCAC 24 0

GGGACGCCCA CCCCAAATAC AAATGGTTTG CCAGTAGCTC ACAAATGAAC CCCATTGCCT 3 00

TGCAC TTAAG CTTCCTGAAG CACATACATA TCCTGCTTTG TGCTTTCCGC CCTATAGTAA 3 60

ACGCAAACCA ATGGAGATGT GAAGCAATCT AATAGCAACA AGGCAAACCT CTACTTCCTC 420

TAAAGAGGAT TGCATCCTCT TGCTATCTTT GCCGATGCTC TCCTACAGAC CCATCCGCTC 4 80

GAG 4 83

(2) INFORMATION FOR SEQ ID NO: 1498:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 144 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 98:

GAATTCGGCC AAAGAGGCCT AAAATTTCAA TAGGCTATAG AGTTTTCCAT GAGAGTGTGT 60
GTGTGTGTGT GTGTGTGTGT GTGTAAAGAA CTCTTACATT TCAGTGAGAA AATATTTTCA 120
TTGAAAGGAA ACACAGAACT CGAG 144

(2) INFORMATION FOR SEQ ID NO : 14 99 :

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 418 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) . TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14 9 9 i

GAATTCGGCC AAAGAGGCCT AAAATAACTG TCCAATTAAC TGAACACTGA GGTAGCTGGG 60

TACAGACTTT AGCGGCTACA TTTGACAAAC ATTGCAATTA C AAGCAG CAA CACAAACCAA 120

CCTTGGGATG GGGATAGAAA TCTTTTCNTT CTTCNTTCTT GGGGGTTTGA GACAGAGTCT 180

CGCTCTGTCA CCCAGGCCGG AGTGCAGTGG CGCAATCTCC GCTCACTGCA AACTCCACCT 24 0

CCTGGGTTCA AGTGATC CTC CTGCCTCAGC CTCCCAAGTA GCTTGGATTA TGGGTGCCCA 3 00

CCACCATGCC TGGCTAATTT TTGTATGTTT GATAGAAACG GTGTTTCACC CTGTTGACCA 360

GGCTGGCCTT GAGCTCCTGA CTTCAGGTGA TCCACCTGCC TCAGCCCCCC GACTCGAG 418

(2) INFORMATION FOR SEQ ID NO: 1500:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 337 base pairs

590

WO 98/45437 PCT/US98/06956

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION : SEQ ID NO: 1500:

GAATTCGGCC AAAGAGGCCT A CAAAGAC C A AGGTATCACA TTCTGCCATT AGCTGCTACC 6 0

TCTCCCTTCC CCATTTTCAG ACAGATTGAG CCCACTTTTT GTGTCCTCCT CTGCTCTTAA 12 0

GCTGTTTCTC ATCGTGGGTG CTCAGCAACT TGTCTGCTCT CACTCTAGTT TCTATTTGCT 18 0

TCCCTGAAAT TAGCCTTTAA CTATGCCCAG ACAAGCCAGA GCCTTGCCTA AACTTCTAAT 24 0

TCCTCTGTGC TTCTTAGTGT ATCCTTTCTG CCTGCTTGCC TGCCTGCCTT CCTGCCTGCT 300

TGCCTGCCTT ACTGACCCTT TGCCCCACGC TCTCGAG 33 7

(2) INFORMATION FOR SEQ ID NO: 1501:

(i) SEQUENCE CHARACTERISTICS:

CA) LENGTH: 105 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS.: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1501:

GAATTCGGCC AAAGAGGCCT AAACCGTCGA TTGAATTCTA GACCAGCCTC ATCTCCTGTT 6 0

CCTCTCTCCC TCCCAACTAT GTTGGCCTCC CTGCTGCTCC TCGAG 105

(2) INFORMATION FOR SEQ ID NO: 1502:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 701 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1502:

GAATTCGGCC AAAGAGGCCT ACTGTGAACC TAAAACTCCT ATAAAGAAAA GTAAAGTCTT 6 0

AAAAACAAAC AAATACACAG CAACAATCTT ATTTTCCCCA GCCTGTCTTA TGTTAGGGTG 120

CAGATGTGAT TTCTGTGTGG CTAATCAGAT GCCCTTGTGT GAGAGACTGA TTTGAACAGA 180

GGCAGGGGCA TCCATCTTTC TAGTGTCAGT CACAGCAGAA GCAGTGAGGT CCTGGTGTCT 24 0

GTCGCTGCAG TGGTGGCTTT TGATACAGGA GTTCCCTGAT GGCAGTAGCT TCTTTGTGGG 3 00

TTCAGTTCTG TTGTGTGGTT CTGCAAGTTC AGCTTAGAGT CTGTTTCTTC AGCTGTTTCA 360

ATGACCCTCT GAGCTGTCTA CCATGAAAAA TTCTATCCTG CTTACACTAA TTAGAGCCAA 4 20

TCCTGTTATT TACAAATGAA TATCCTGACC AGTAATGAAG GTCTAGACTT AACTGTAATA 4 80

TTTTATGACT TAAATTG TTG GCATATGTGA AAACTTTTTG TTTATTCTAA ACTTTTTTGT 54 0

TGTTGTTGTA AAATAAAACA TTTATGAAAA G CGCACCAAA AAGGATAACA AATGAGAGTA 6 00

ATGCAACATA CAGGCACCAG CAACTCAGGC CAGGGAGATG ATATATG AG C ATCCCCAATC 660

TCCCCTTTAC ACTCCCTCAA ATAACTCAAT CAAGACTCGA G 701

(2) INFORMATION FOR SEQ ID NO: 1503:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 257 base pairs

591

WO 98/45437

PCT7US98/06956

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE; cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1503:

GAATTCGGCC TTCATGGCCT AG GAACTAG G TGACTTTGGG GCTCATCTCA CAAGTTTCCT 60

TACACTTAGG GATCAGTCTT TTGCTTCCTG TTGTCCTCTG CCTGAAAGTA GTTGCCAAGT 120

TGTACTGTTT TATATATCCA CCACAG CATG AG TTAAAC CA AAGTCTGGAT CAGCAGACTG 180

CCAGATTTTT TTTTAACAAA TTTATTAATC AATACATTTT GTCCATGTCT ACAGTTGTTT 24 0

ATGGGGGAGA ACTCGAG 257

(2) INFORMATION FOR SEQ ID NO: 1504:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2 77 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS : double
(D) TOPOLOGY: linear

Cii) MOLECULE TYPE: cDNA

{xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1504:

GAATTCGGCC TTCATGGCCT AGGGGACCTT GGGAGAATGT AATCCCTGCC CCTAGTCTCA 60

GTTTCTGCAT CCACGGAAGA GGGGTGAAGA TGGTCCCTAC CCCTCCAGAA TGTTCTTTTT 12 0

TTTTTTTTTT AAAAAAAAAA AAAAAAAAAA AAAGTACGTT ATGTTTTCAG ATAAGAACAC 180

TTCTTCATGG ATGACTTGAA ATAATTG CCA TGGTCCCTAA GTTTTCCTCT CTGTAGATGA 24 0

ATGATATAGC TCAGTATCTA AGCAGTGGAT CCTCGAG 277

(2) INFORMATION FOR SEQ ID NO: 1505:

(i) SEQUENCE CHARACTERISTICS :

(A) LENGTH: 3 41 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double
<D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1505:

GAATTCGGCC TTCATGGCCT AGACCTGCCT CGAGCCTCCC AAGCTGCTGG TATTACAGGC 6 0

GTGAACCACt GCACCTGGCC TAATACGATA TTCTTACAAT TTAAAAAATG AAAGCAGAGG 120

AATGGTGGCA GGGAAGCTGA CATTTTAAGA GTTCACTTCC TTG TAGTTAT CACAGTTAAT 180

TCTTACTGTT AGAATAAGTG GTAACTTGCC AAGGTCACAT TGCTAGATGT C AG AG CAG AA 24 0

ATTAGAAATC AGGTCTAGCC AAGGCCATCA CACTTCTCAG AG CATT AACA ATT CAATTCA 3 00

GTTAGTGTTT ATTGAACACC TATTGTGTTC TGGCCCTCGA G 341

(2) INFORMATION FOR SEQ ID NO: 1506:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 270 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

592

WO 98/45437

PCT7US98/06956

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1506:

GAATTCGGCC TTCATGGCCT AGGCATTTTG TCTCTAGAAT TACCCACCCG TTCCTGCGCT 6 0

CTACGGTTCT CCATGCCCCC TCCAGTTTGG GGGTCTAAAC CGAACAGGAG AGGTGCAGGG 12 0

GACCAGGAGG TGTCCTGGCA CAAAGGTTCG GGGGTCTCCC TGGCAAGGGG TCCCAGGGCC 180

TGGAGCCCGA GGCCCAGCCA AAAGCACACA GCATCAAAAC ATGTTTTTAG TGGGAAGCTC 24 0

CAGGCCCTGC CCCTCCCCGG GGGCCTCGAG 270

(2) INFORMATION FOR SEQ ID NO : 1507 :

(i) SEQUENCE CHARACTERISTICS ;

(A) LENGTH: 4 62 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1507:

GAATTCGGCC TTCATGGCCT AGAGCAGGAA GATTGTGTGA GTGCTGGGGT TTGGGGGTGC 60

CCAAGTTGGG AAC CAGTGGA GGGAGAGAGA GGTAGGAGGT AGATGGATGG AGATCAAAGG 120

CCAGGCCTGT GGCCAAGGGG GCTGCTAACC CTTCAACCCT GTGTTAGCCT GTACACTCAC 180

CAGG CCAGGC TCAGCAGGCG GGCTGTTCAC CTCCTGGCAG CAAATGGTCC AGAATGTGCC 24 0

CTCGCTGCAG CCCAGCTGGC TCCAGAAGGG GGACCACAGA GGCTGGAGCT ATGCATGCAC 3 00

AGTGCTTTCT CCCAACCTTG CTTCTGAGAA AAGTGTCCCT GCGAGGGCCC TGGAGGAGGG 3 60

AGCTAGGGAC CAGCAGAAGG GCCTAGGTTT CTG TAG CAT C ATTTTTAGCC CTGGCTGAAT 42 0

CTGGGAAGCA CCTGGTGGCT TTAACAT TCC CGTTAGCTCG AG 4 62

(2) INFORMATION FOR SEQ ID NO:1508:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 6 94 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1508:

GAATTCGGCC TTCATGGCCT AGTCACAATC CACTTAAAGA AGTTTGGTTA TATTTCAGTG 60

AAAATTTTCT TCCAGAGTAG GTTTTTTTTC GTGGGTTGGG GGGTAACTTT ACTACAATTA 120

GTAAGTATGG TGCAGAATTT CATG CAAATG AGGAGTGCCA GCAGTGTGAT AATTTAAACA 18 0

TATTTAAACA AAAACAAAAA AAATGAATGC ACAAACTTGC TGCTGCTTAG ATCACTGCAG 24 0

CTTCTAGGAC CCGGTTTCTT TTACTGATTT AAAAACAAAA CAAAAAAAAA TAAAAAAGTT 3 00

GTG CCTG AAA TGAATCTTGT TTTTTTTTAT AAGTAGCCGC CTGGTTACTG TGTCCTGTAA 36 0

AATACAGACA CTTGACCCTT GGTGTAGCTT CTGTTCAACT TTATATCACG GGAATGGATG 420

GGTCTGATTT CTTGGCCCTC TTCTTGAATT GGCCATATAC AGGGTCCCTG GCCAGTGGAC 4 80

TGAAGGCTTT GTCTAAGATG ACAAGGGTCA GCTCAGGGGA TGTGGGGGAG GGCGGTTTTA 54 0

TCTTCCCCCT TGTCGTTTGA GGTTTTGATC TCTGGGTAAA GAGGCCGTTT ATCTTTGTAA 600

ACACGAAACA TTTTTGCTTT CTCAAGTTTT CTGTTAATGG CGAAAGAATG GAAGCGAATA 660

AAGTTTTACT GATTTTTGAG ACACTAGACT CGAG 6 94

(2) INFORMATION FOR SEQ ID NO: 1509;

(i) SEQUENCE CHARACTERISTICS:

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(A) LENGTH: 4 90 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1509:

GAATTCGGCC TTCATGGCCT AATGAGGTTC TATCTAGAGG TGATGGGAGA CAGTGACAGA 60

TCATCAGGCA TTAGATTCTC ATAAGGACTG CGCAACCTAG AT CCCTTGAA TGAACAGTTC 12 0

ACAATAGGGT TCACTCTCCA ATGAGAATCT AATGCTGCCG CTGATCTGAC AGGTGCCAGA 180

GCTCAGGCGG TAATACGAGA GG CTGG AG AT ACAGATAAAG CTTCAGTTGC TTGCCCGCCA 24 0

CTTACCTCCT CTTGTGCGGC CCAGTTCCTA ACAGGCCACA GACCGCTACC AGTCCATGGC 30 0

CTGGAAGTTG GGGACCCCTC TACTGGGATA TTTATAATTG CATATGTGGT TACCTAATAT 3 60

TTCCATGATA CAACACTGGT CTAGATT CTA GGCCATTCTC CTTCAAAAAG AACCCTGCTT 42 0

CCTTACAGTT TTACTGTTTA GCAGCAATGT TTTCTACCCC TTCTTAAAAT TTTCAGCCAC 4 80

CACACTCGAG 4 90

(2) INFORMATION FOR SEQ ID NO: 1510:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 313 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1510:

GAATTCGGCC TTCATGGCCT ACTCTCTCAT TCCTACCCTC CTCCCCTCCA CTCACGCTCC 6 0

TCCCAATCCC CAAGGTCCTC TCATTCCCAC CTTCCTCCCT TCCTCTCCTC ACGCTCCTCC 120

CTATCCCCGA GCTCCTCTCT CATCCCTACC CTCCTCCCCT CCACTCACGC TCCTCCCAAT 180

CCCCAAGGTC CTCTCATTCC CACCTTCCTC CCTTCCTCTC CTCACGCTCC TCCCTATCCC 24 0

CGAGCTCCTC TCTCACTCCC TCCCTCCTCT CATGCTCCTC CCCCCTCTCC TCATGCTCCT 300

CCCCATCCTC GAG 313

(2) INFORMATION FOR SEQ ID NO: 1511:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 3 54 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(Xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1511:

GCCGGGTGGG CCGGAGGTGG CGCGGCCGCA CGGCTTTGTT CCGGAAAGCC CTTAGGTGGA 60

GAGCGATGTG GGGCGCGGCA GGGGGATCGC GTAGAGGAAC CTTCGCGCAC CGCCTCTCCG 120

GGTCTGGGAA TCTGCTGAAC TCCTTGCCTC TCTTGGGGTC CCTCGAACGC CCCAGCTAAG 180

AAGGGCGGGG GCCTTGCCAG GGCGCGAGCA ACATGACGTT CAAGGTCTTC CTGTGGCTTC 24 0

TGTAAAGAAA TGTTCACGTG GGAGCCTGTC CACATGGGCT G TACTAAGG A TCTGGCACGA 3 00

GGAAGAAATA TCACTG CAGA ACCTGAAGCC CTCCGTTGGA AGGGTCACCT CGAG 3 54

(2) INFORMATION FOR SEQ ID NO: 1512;

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(i) SEQUENCE CHARACTERISTICS:

<A) LENGTH: 4 07 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
< D ) TOPOLOGY : 1 inear

(ii) MOLECULE TYPE: cDNA

<xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1512:

GAATTCGGCC AAAGAGGCCT AGAGCAGCTT GGCTAAAAGT AAGGGTGTCG TGCTGATGGC 60

CCTGTGCGCA CTGACCCGCG CTCTGCGCTC TCTGAACCTG GCGCCCCCGA CCGTCGCCGC 12 0

CCCTGCCCCG AGTCTGTTCC CCGCCGCCCA GATGATGAAC AATGGCCTCC TCCAACAGCC 18 0

CTCTGCCTTG ATGTTGCTCC CCTGCCGCCC AGTTCTTACT TCTGTGGCCC TTAATG CCAA 24 0

CTTTGTGTCC TGGAAGAGTC GTACCAAGTA CAC CATTAC A CCAGTGAAGA TGAGGAAGTC 300

TGGGGGCCGA G AC CACAC AG GTGGGAACAA GGACAGGGGG ATTTAAGCAG TCAAAAGGAA 36 0

AAACATGTTA AGACCCTAGA CTTGTATATT GACACACAGA ACTCGAG 4 07

(2) INFORMATION FOR SEQ ID NO:1513:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 22 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: double

(D) TOPOLOGY: linear

{ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1513:

GAATTCGGCC AAAGAGGCCT ACATTCATAC AATTACAGAA TTCAAATATT GCAAAAGGAT 6 0

GTGTGTCTTT CTCCCCGAGC TCCCCTGTTC CCCTTCATTG AAAACCACCA CGGTGCCATC 120

TCTTGTGTAT GCAGGGCTAT GCACCTGCAG GCACGTGTGT ATGCACTCCC CGCTTGTGTT 160

TACACAAGCT GTGGGGTGTT ACGCATGCCT GCTTTTTTCA CTTAATAATA CAGCTTGGAG 24 0

AGATTTTTGT ATCACATTAT AAATCCCACT CGCTCTTTTT GATGGCCACA TAATAACTAC 3 00

TG CATAATAT GGATACG CCT TATTTGATTT AACTAGTTCC CTAATGATGG ACTTTTAAGT 36 0

TGTTTCCTTT TTTTTTCTTT TTTG CTACTG CAAACGATGC TATCTAGGCC TCTTTGGCCG 4 20

AA 422

(2) INFORMATION FOR SEQ ID NO:1514:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 4 85 base pairs

(B) TYPE: nucleic acid
<C) STRANDEDNESS: double
(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1514:

GAATTCGGCC AAAGAGGCCT ATGGAAATTC AAGACCTGAT GTTTGAGGAG ATGAGGGAAA 60

CTCTTAAAAA TG AC CTAAAA GCAGTTTTAG GAGGAAAAGC TACAATACCT GAGGTAAAGA 120

ATTCAGAGAA CTCCAGTAGT AGGACAGAGT TTCAGCAAAT AATCAATTTA GCATTACAAA 180

AAACAGGGAT GGTAGGGAAA ATAGAAGGAG AAAACTCTAA AATAGGTGAT GATAATGAAA 2 40

ATTTAACCTT TAAATTAGAA GTAAATGAGC TGAGTGGTAA ATTAGACAAC ACTAACGAAT 3 00

ACAATAGTAA TGATG GTAAG AAATTACCCC AGGGTGAATC ACGAAGTTAC GAAGTCATGG 3 60

GAAGTATGGA AGAAACCTTA TGCAATATAG ATGACAGAGA TGGAAATCGC AATGTCCATT 420

TAGAATTTAC AGAAAGAGAG AGTAGGAAGG ATGGAGAGGA TGAATTTGTC AAAGAAAAAC 4 80

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TCGAG 4 8 5

(2) INFORMATION FOR SEQ ID NO: 1515:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 400 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS ; double
<D> TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1515:

GAATTCGGCC AAAGAGGCCT AGGCACAGAA GGGTGGTGAG TGTGATCAAA TCTAGTCTCA 60

CTCCCACTTT TTAGTCTCAC TCCTACTTTT GTCCACCACC CAGGCACGGA GAGAAAGGAA 12 0

TGTTTAGCAC AAGACAC AG C GGAGCTCGGG ATTGG CTAAA CTCCCATAGT ATTTATGGTG 180

GCCGCCGGCG GGGGCCCCAG CCCAGCTTGC AGGCCACCTC TAGCTTTCTT CCTACCCCAT 24 0

TCCCGGCTTC CCTCCTCCTC CCCTGCAGCC TGGTTAGGTG GATACCTGCC CTGACATGTG 300

AGGCAAGCTA AGG CCTGG AG GGTCAGATGG GAGACCAGGT CC CAAGG GAG CAAGACCTCG 36 0

CGAAGCGCAG CAGCCCCGGC CCTAGGCCTC TTTGGCCGAA 400

(2) INFORMATION FOR SEQ ID NO:1516:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 145 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE : cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1516:

GAATTCGCGG CCGCGTCGAC GTCGACGCGG CCGCGAATTC GGCCAAAGAG GCCTACCCAT 60
G TCAATCAAG ATGGGTGATT ATGAAATGCC AGACTTCTAA AATAAATGTT TTGGAATTCA 120
ATGGGTAAAT AAATGCTGGC TCGAG 145

(2) INFORMATION FOR SEQ ID NO:15l7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 277 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double
<D) TOPOLOGY: linear

(ii) ' MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1517:

GCTGGACCTC CTGTGCAAGA ACATGAAACA GCTGTGGTTC TTCCTTCTCC TGGTGGCAGC 60

TCCCAGATCG GTTCTGTCCC AGGTGCAGCT GCGGGAGTCG GGCCCAGGAC TGGTGAAGCC 120

TTCGGAGACC CTGTCCCTCA CCTGCACTGT CTC TGGTACT TCCGTCAGAA GTGTTAGTTA 180

CGACTGGAGT TGGCTCCGGC AGTCCCCGGG GAAGGGACTG GAGTGGCTTG GAGAGATTGA 24 0

TTACAGGGGG AGAGGCAATT ACAACCCGTC CCTCGAG 2 77

(2) INFORMATION FOR SEQ ID NO: 1518:
(i) SEQUENCE CHARACTERISTICS :

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(A) LENGTH: 161 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double •

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1518:

GAATTCGGCC AAAGAGGCCT ACTCATGCAC CTAATTGGAT CCTATCTTTG TGTTGTTAGC 60
TGGTTATTAT GCAGACTTTA TTATGTGGTT GTTTTATAGT GTCCATAACC TATGTACTTA 12 0

AGTTTGTTTT TGTGGTGGCG CTTCCAATTA GGGCTCTCGA G 161

(2) INFORMATION FOR SEQ ID NO: 1519:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 561 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS : double

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: cDNA

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1519:

GAATTCGGCC TTCATGGCCT AATATAAAAC AATGTTTTTC AAGGCATTAT ATAATAGGCT 60

AAGGACAGTG ACCTCCAAGA GACAGCAAAC AAGGTAATAC CTGTGACTGC TCCAGCTTAC 120

TGCCTTGAGA GAATTAATAG TAGGTTTGTG GTACAGGGAG GGAGAATCCA GTCAGAGCCC 180

AG CGG ACTTG CTGAATTAAG GAAATGGAGC TGAGAGTCCA GAGAGACCAA CATGGCTAAA 24 0

GTTGTCATGA CAGAGCACTC AGAACTAGAG AG CTG CACAG CAACATAACC TAAGAG CTCT 3 00

GAAGATAATC TCCCTCAAAT ACTCAGCTGA GTACTGATCA ACATATATGT GTGAGGAAGC 360

TATCTGAGGC TGACAAAGAA CTG CCTGAAG AGATTAGAGG GAACAGTACT TGGCACTCAC 420

ACAGAATTGG AAACTGTACC TGTTCCCACC AGC CAAACTG GAAAAACCTC AGGATTCATG 480

GGGTACTCAG AAAGGACTTG CATCAGGTAT GGGGAATAAT TAGCCCTAGA CAGAGCACTG 540

CTCTAATCCC ATCCACTCGA G 561

597

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What is claimed is:

1 . An isolated polynucleotide comprising a nucleotide sequence selected from the
group consisting of:

SEQ ID NO: 1 , SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ
ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9. SEQ ID NO: 10, SEQ ID
NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ
ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO:20, SEQ
ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ
ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ
ID NO:31 , SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ
ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ
ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ
ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ
ID NO:51, SEQ ID NO: 52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ
ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ
ID NO: 61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ
ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ
ID NO:71 , SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ
ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ
ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84 t SEQ ID NO:85, SEQ
ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ
ID NO:91, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ
ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO: 100,
SEQ ID NO-.101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID
NO: 105, SEQ ID NO: 106, SEQ ID NO: 107, SEQ ID NO: 108, SEQ ID NO: 109,
SEQ ID NO: 1 10, SEQ ID NO: 11 1, SEQ ID NO: 112, SEQ ID NO: 1 13, SEQ ID
NO: 1 14, SEQ ID NO: 1 15, SEQ ID NO: 1 16, SEQ ID NO: 1 17, SEQ ID NO: 118,
SEQ ID NO: 119, SEQ ID NO: 120, SEQ ID NO: 121, SEQ ID NO: 122, SEQ ID
NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 127,
SEQ ID NO: 128, SEQ ID NO: 129, SEQ ID NO: 130, SEQ ID NO: 131, SEQ ID
NO: 132, SEQ ID NO: 133, SEQ ID NO: 134, SEQ ID NO: 135, SEQ ID NO: 136,
SEQ ID NO: 137, SEQ ID NO: 138, SEQ ID NO: 139, SEQ ID NO: 140, SEQ ID
NO: 141, SEQ ID NO: 142, SEQ ID NO: 143, SEQ ID NO: 144, SEQ ID NO: 145,

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SEQ ID NO: 146, SEQ ID NO: 147, SEQ ID NO: 148, SEQ ID NO: 149, SEQ ID
NO: 150, SEQ ID NO: 15 1, SEQ ID NO: 152, SEQ ID NO: 153, SEQ ID NO: 154,
SEQ ID NO: 155, SEQ ID NO: 156, SEQ ID NO: 157, SEQ ID NO: 158, SEQ ID
NO: 159, SEQ ID NO: 160, SEQ ID NO: 161, SEQ ID NO: 162, SEQ ID NO: 163,
SEQ ID NO: 164, SEQ ID NO: 165, SEQ ID NO: 166, SEQ ID NO: 167, SEQ ID
NO: 168, SEQ ID NO: 169, SEQ ID NO: 170, SEQ ID NO: 171, SEQ ID NO: 172,
SEQ ID NO: 173, SEQ ID NO: 174, SEQ ID NO: 1 75, SEQ ID NO: 176, SEQ ID
NO: 177, SEQ ID NO: 178, SEQ ID NO: 179, SEQ ID NO: 180, SEQ ID NO: 181,
SEQ ID NO: 182, SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO: 185, SEQ ID
NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, SEQ ID NO: 189, SEQ ID NO: 190,
SEQ ID NO:191, SEQ ID NO:192, SEQ ID NO:193, SEQ ID NO:194, SEQ ID
NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199,
SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID
NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208,
SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:211, SEQ ID NO:212, SEQ ID
NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217,
SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID
NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226,
SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID
NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235,
SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238, SEQ ID NO:239, SEQ ID
NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244,
SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:247, SEQ ID NO:248, SEQ ID
NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253,
SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID
NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:261, SEQ ID NO:262,
SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID
NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271,
SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275, SEQ ID
NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280,
SEQ ID NO:281, SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID
NO:285, SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289,
SEQ ID NO:290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID NO:293, SEQ ID
NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298,

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SEQ ID NO:299, SEQ ID NO:300. SEQ ID NO:301, SEQ ID NO:302, SEQ ID
NO:303, SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307,
SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:3tO, SEQ ID NO:311, SEQ ID
NO:3I2, SEQ ID NO:313, SEQ ID NO:314, SEQ ID NO:315, SEQ ID NO:316,
SEQ ID NO:317, SEQ ID NO:3l8, SEQ ID NO:319, SEQ ID NO:320, SEQ ID
NO:321, SEQ ID NO:322, SEQ ID NO:323, SEQ ID NO:324, SEQ ID NO:325,
SEQ ID NO;326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID
NO:330, SEQ ID NO:331, SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334,
SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO:338, SEQ ID
NO:339, SEQ ID NO:340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO:343,
SEQ ID NO:344, SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID
NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352,
SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356, SEQ ID
NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO.360, SEQ ID NO:361,
SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365 t SEQ ID
NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369, SEQ ID NO:370,
SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373, SEQ ID NO:374 t SEQ ID
NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379,
SEQ ID NO:380, SEQ ID NO:381, SEQ ID NO:382, SEQ ID NO:383, SEQ ID
NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388,
SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID
NOI393, SEQ ID NO:394, SEQ ID NO:395, SEQ ID NO:396, SEQ ID NO:397,
SEQ ID NO:398 T SEQ ID NO:399, SEQ ID NO;400, SEQ ID NO:401, SEQ ID
NO:402, SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406,
SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410 t SEQ ID
NO:411,SEQ ID NO:412,SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415,
SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418, SEQ ID NO:419, SEQ ID
NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424,
SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428, SEQ ID
NO:429, SEQ ID NO:430, SEQ ID NO:431 t SEQ ID NO:432, SEQ ID NO:433,
SEQ ID NO:434, SEQ ID NO:43S, SEQ ID NO:436, SEQ ID NO:437, SEQ ID
NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441, SEQ ID NO:442,
SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446, SEQ ID
NO:447, SEQ ID NO:448, SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451,

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SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID
NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO;459, SEQ ID NO:460,
SEQ ID NO:461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO: 464, SEQ ID
NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469,
SEQ ID NO:470, SEQ ID NO:471, SEQ ID NO:472, SEQ ID NO:473, SEQ ID
NO:474, SEQ ID NO:475, SEQ ID NO:476, SEQ ID NO:477, SEQ ID NO:478 t
SEQ ID NO:479, SEQ ID NO:480, SEQ ID NO:481, SEQ ID NO:482, SEQ ID
NO:483, SEQ ID NO:484, SEQ ID NO:485, SEQ ID NO:486, SEQ ID NO:487,
SEQ ID NO:488, SEQ ID NO:489, SEQ ID NO:490, SEQ ID NO:491, SEQ ID
NO:492, SEQ ID NO:493, SEQ ID NO:494, SEQ ID NO:495, SEQ ID NO:496,
SEQ ID NO:497, SEQ ID NO:498, SEQ ID NO:499, SEQ ID NO:500, SEQ ID
NO:501, SEQ ID NO:502, SEQ ID NO:503, SEQ ID NO:504, SEQ ID NO:505,
SEQ ID NO:506, SEQ ID NO:507 T SEQ ID NO:508, SEQ ID NO:509, SEQ ID
NO:510, SEQ ID NO:51 1, SEQ ID NO:512 T SEQ ID NO:513 t SEQ ID NO:514,
SEQ ID NO:515, SEQ ID NO:516, SEQ ID NO:517, SEQ ID NO:518, SEQ ID
NO:519, SEQ ID NO:520, SEQ ID NO:521, SEQ ID NO:522, SEQ ID NO:523,
SEQ ID NO:524, SEQ ID NO:525, SEQ ID NO:526, SEQ ID NO:527, SEQ ID
NO:528, SEQ ID NO:529, SEQ ID NO:530, SEQ ID NO:531, SEQ ID NO:532,
SEQ ID NO:533, SEQ ID NO:534, SEQ ID NO:535, SEQ ID NO:536, SEQ ID
NO:537, SEQ ID NO:538, SEQ ID NO.539, SEQ ID NO:540, SEQ ID NO:541,
SEQ ID NO:542, SEQ ID NO:543, SEQ ID NO:544, SEQ ID NO:545, SEQ ID
NO:546, SEQ ID NO:547, SEQ ID NO:548, SEQ ID NO:549, SEQ ID NO:550 T
SEQ ID NO:55i, SEQ ID NO:552, SEQ ID NO:553, SEQ ID NO:554, SEQ ID
NO:555, SEQ ID NO:556, SEQ ID NO:557, SEQ ID NO:558, SEQ ID NO:559,
SEQ ID NO:560 t SEQ ID NO:561, SEQ ID NO:562, SEQ ID NO:563, SEQ ID
NO:564, SEQ ID NO:565, SEQ ID NO:566, SEQ ID NO:567, SEQ ID NO:568,
SEQ ID NO:569, SEQ ID NO:570, SEQ ID NO:571, SEQ ID NO:572, SEQ ID
NO:573, SEQ ID NO:574, SEQ ID NO:575, SEQ ID NO:576, SEQ ID NO:577,
SEQ ID NO:578, SEQ ID NO:579, SEQ ID NO:580, SEQ ID NO:581, SEQ ID
NO:582, SEQ ID NO:583, SEQ ID NO:584, SEQ ID NO:585, SEQ ID NO:586,
SEQ ID NO:587, SEQ ID NO:588, SEQ ID NO:589, SEQ ID NO:590, SEQ ID
NO:591, SEQ ID NO:592, SEQ ID NO:593, SEQ ID NO:594, SEQ ID NO:595,
SEQ ID NO:596, SEQ ID NO:597, SEQ ID NO:598, SEQ ID NO:599, SEQ ID
NO:600, SEQ ID NO:601, SEQ ID NO:602, SEQ ID NO:603, SEQ ID NO:604,

601

WO 98/45437

PCT/US98/06956

SEQ ID NO:605. SEQ ID NO:606, SEQ ID NO:607, SEQ ID NO:608, SEQ ID
NO:609, SEQ ID NO:6iO, SEQ ID NO:6i 1, SEQ ID NO:6I2, SEQ ID NO:613,
SEQ ID NO:614, SEQ ID NO:615, SEQ ID NO:6l6, SEQ ID NO:617, SEQ ID
SEQ ID NO:619, SEQ ID NO:620, SEQ ID NO:621, SEQ ID NO:622,
SEQ ID NO:623, SEQ ID NO:624, SEQ ID NO:625, SEQ ID NO:626, SEQ ID
NO:627, SEQ ID NO:628, SEQ ID NO:629, SEQ ID NO:630, SEQ ID NO:631,
SEQ ID NO:632, SEQ ID NO:633, SEQ ID NO:634, SEQ ID NO:635, SEQ ID
NO:636, SEQ ID NO:637, SEQ ID NO:638, SEQ ID NO:639, SEQ ID NO:640,
SEQ ID NO:641, SEQ ID NO:642, SEQ ID NO:643, SEQ ID NO:644, SEQ ID
NO:645, SEQ ID NO:646 t SEQ ID NO:647, SEQ ID NO:648, SEQ ID NO:649,
SEQ ID NO:650, SEQ ID NO:651, SEQ ID NO:652, SEQ ID NO:653, SEQ ID
NO:654, SEQ ID NO:655, SEQ ID NO:656, SEQ ID NO:657, SEQ ID NO:658 t
SEQ ID NO:659, SEQ ID NO:660, SEQ ID NO:661, SEQ ID NO:662, SEQ ID
NO:663, SEQ ID NO:664, SEQ ID NO:665, SEQ ID NO:666, SEQ ID NO:667,
SEQ ID NO:668, SEQ ID NO:669, SEQ ID NO:670 T SEQ ID NO:671, SEQ ID
NO:672, SEQ ID NO:673, SEQ ID NO:674, SEQ ID NO:675, SEQ ID NO;676,
SEQ ID NO:677, SEQ ID NO:678, SEQ ID NO:679, SEQ ID NO:680 r SEQ ID
NO:681, SEQ ID NO:682, SEQ ID NO:683, SEQ ID NO:684, SEQ ID NO:685,
SEQ ID NO:686, SEQ ID NO:687, SEQ ID NO:688, SEQ ID NO:689, SEQ ID
NO:690, SEQ ID NO:691, SEQ ID NO:692, SEQ ID NO:693, SEQ ID NO:694,
SEQ ID NO:695, SEQ ID NO:696, SEQ ID NO:697, SEQ ID NO:698, SEQ ID
NO:699, SEQ ID NO:700, SEQ ID NO:701, SEQ ID NO:702, SEQ ID NO:703,
SEQ ID NO:704, SEQ ID NO:705, SEQ ID NO:706, SEQ ID NO:707, SEQ ID
NO:708, SEQ ID NO:709, SEQ ID NO:710, SEQ ID NO:711, SEQ ID NO:712,
SEQ ID NO:713, SEQ ID NO:714, SEQ ID NO:7I5, SEQ ID NO:716, SEQ ID
NO:717, SEQ ID NO:718, SEQ ID NO:719, SEQ ID NO:720, SEQ ID NO:721,
SEQ ID NO:722, SEQ ID NO:723, SEQ ID NO:724, SEQ ID NO:725 7 SEQ ID
NO:726, SEQ ID NO:727, SEQ ID NO:728, SEQ ID NO:729, SEQ ID NO:730,
SEQ ID NO:73I, SEQ ID NO:732, SEQ ID NO:733, SEQ ID NO:734, SEQ ID
NO:735, SEQ ID NO:736, SEQ ID NO:737, SEQ ID NO:738, SEQ ID NO:739,
SEQ ID NO:740, SEQ ID NO:741, SEQ ID NO:742, SEQ ID NO:743, SEQ ID
NO:744, SEQ ID NO:745, SEQ ID NO:746, SEQ ID NO:747, SEQ ID NO:748,
SEQ ID NO:749, SEQ ID NO:750, SEQ ID NO:751, SEQ ID NO:752, SEQ ID
NO:753, SEQ ID NO:754, SEQ ID NO:755, SEQ ID NO:756, SEQ ID NO:757,

602

WO 98/45437

PCT/US98/06956

SEQ ID NO;758, SEQ ID NO:759, SEQ ID NO:760, SEQ ID NO:761, SEQ ID
NO:762, SEQ ID NO:763, SEQ ID NO:764, SEQ ID NO:765, SEQ ID NO:766,
SEQ ID NO:767, SEQ ID NO:768, SEQ ID NO:769, SEQ ID NO:770, SEQ ID
NO:77K SEQ ID NO:772, SEQ ID NO:773, SEQ ID NO:774, SEQ ID NO:775,
SEQ ID NO:776, SEQ ID NO:777, SEQ ID NO;778, SEQ ID NO:779, SEQ ID
NO:780, SEQ ID NO:781, SEQ ID NO:782. SEQ ID NO:783, SEQ ID NO:784,
SEQ ID NO:785, SEQ ID NO:786, SEQ ID NO:787, SEQ ID NO:788, SEQ ID
NO:789, SEQ ID NO:790, SEQ ID NO:791, SEQ ID NO:792, SEQ ID NO:793,
SEQ ID NO:794 T SEQ ID NO:795, SEQ ID NO:796, SEQ ID NO:797, SEQ ID
NO:798, SEQ ID NO:799, SEQ ID NO:800, SEQ ID NO:801, SEQ ID NO:802,
SEQ ID NO:803, SEQ ID NO:804, SEQ ID NO:805, SEQ ID NO:806, SEQ ID
NO:807, SEQ ID NO:808, SEQ ID NO:809, SEQ ID NO:810, SEQ ID NO:81 1,
SEQ ID NO:812, SEQ ID NO:813, SEQ ID NO:814, SEQ ID NO:815, SEQ ID
NO:816, SEQ ID NO:817, SEQ ID NO:818, SEQ ID NO:819, SEQ ID NO:820,
SEQ ID NO:821, SEQ ID NO:822, SEQ ID NO: 823, SEQ ID NO:824, SEQ ID
NO:825, SEQ ID NO:826, SEQ ID NO:827, SEQ ID NO:828, SEQ ID NO:829,
SEQ ID NO:830, SEQ ID NO:831, SEQ ID NO;832, SEQ ID NO:833, SEQ ID
NO:834, SEQ ID NO:835, SEQ ID NO:836, SEQ ID NO:837, SEQ ID NO:838,
SEQ ID NO:839, SEQ ID NO:840, SEQ ID NO:841, SEQ ID NO:842, SEQ ID
NO:843, SEQ ID NO:844, SEQ ID NO:845, SEQ ID NO:846, SEQ ID NO:847,
SEQ ID NO:848, SEQ ID NO:849, SEQ ID NO:850, SEQ ID NO:851, SEQ ID
NO:852, SEQ ID NO:853, SEQ ID NO:854, SEQ ID NO:855, SEQ ID NO:856,
SEQ ID NO:857, SEQ ID NO:858, SEQ ID NO:859, SEQ ID NO:860, SEQ ID
NO:861, SEQ ID NO:862, SEQ ID NO:863, SEQ ID NO:864, SEQ ID NO:865,
SEQ ID NO:866, SEQ ID NO:867, SEQ ID NO:868, SEQ ID NO:869, SEQ ID
NO:870, SEQ ID NO:871, SEQ ID NO:872, SEQ ID NO:873, SEQ ID NO:874,
SEQ ID NO:875, SEQ ID NO:876, SEQ ID NO:877, SEQ ID NO:878, SEQ ID
NO:879, SEQ ID NO:880, SEQ ID NO:881, SEQ ID NO:882, SEQ ID NO:883,
SEQ ID NO:884, SEQ ID NO:885, SEQ ID NO:886, SEQ ID NO:887, SEQ ID
NO:888, SEQ ID NO:889, SEQ ID NO:890, SEQ ID NO:891, SEQ ID NO:892,
SEQ ID NO:893, SEQ ID NO:894, SEQ ID NO:895, SEQ ID NO:896, SEQ ID
NO:897, SEQ ID NO:898, SEQ ID NO:899, SEQ ID NO:900, SEQ ID NO.901,
SEQ ID NO:902, SEQ ID NO:903, SEQ ID NO:904, SEQ ID NO:905, SEQ ID
NO:906, SEQ ID NO:907, SEQ ID NO:908, SEQ ID NO:909, SEQ ID NO:910,

603

mmm

WO 98/45437

PCT/US98/06956

SEQ ID NO:911, SEQ ID NO:9l2, SEQ ID NO:913, SEQ ID NO:9i4, SEQ ID
NO:915, SEQ ID NO:9I6, SEQ ID NO:9I7, SEQ ID NO:9I8, SEQ ID NO:919,
SEQ ID NO:920, SEQ ID NO:921, SEQ ID NO;922, SEQ ID NO:923, SEQ ID
NO:924, SEQ ID NO:925, SEQ ID NO:926, SEQ ID NO:927, SEQ ID NO:928,
SEQ ID NO:929, SEQ ID NO:930, SEQ ID NO:931, SEQ ID NO:932, SEQ ID
NO:933, SEQ ID NO:934, SEQ ID NO:935, SEQ ID NO:936, SEQ ID NO:937,
SEQ ID NO:938, SEQ ID NO:939, SEQ ID NO:940, SEQ ID NO:941, SEQ ID
NO:942, SEQ ID NO:943, SEQ ID NO:944, SEQ ID NO:945, SEQ ID NO:946,
SEQ ID NO:947, SEQ ID NO:948, SEQ ID NO:949, SEQ ID NO:950, SEQ ID
NO:951, SEQ ID NO:952, SEQ ID NO:953, SEQ ID NO:954, SEQ ID NO:955,
SEQ ID NO:956, SEQ ID NO:957, SEQ ID NO:958, SEQ ID NO:959, SEQ ID
NO:960, SEQ ID NO:961, SEQ ID NO:962, SEQ ID NO:963, SEQ ID NO:964,
SEQ ID NO:965, SEQ ID NO:966, SEQ ID NO:967, SEQ ID NO:968> SEQ ID
NO:969, SEQ ID NO:970, SEQ ID NO:971, SEQ ID NO:972, SEQ ID NO:973,
SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:976, SEQ ID NO:977, SEQ ID
NO:978, SEQ ID NO:979, SEQ ID NO:980, SEQ ID NO:981, SEQ ID NO:982,
SEQ ID NO:983, SEQ ID NO:984, SEQ ID NO:985, SEQ ID NO:986, SEQ ID
NO:987, SEQ ID NO:988, SEQ ID 1^0:989, SEQ ID NO:990, SEQ ID NO:991,
SEQ ID NO:992 T SEQ ID NO:993, SEQ ID NO:994, SEQ ID NO:995, SEQ ID
NO:996, SEQ ID NO:997, SEQ ID NO:998, SEQ ID NO:999, SEQ ID NO: 1000,
SEQ ID NO: 1001, SEQ ID NO: 1002, SEQ ID NO: 1003, SEQ ID NO: 1004, SEQ
ID NO: 1005, SEQ ID NO: 1006, SEQ ID NO: 1007, SEQ ID NO: 1008, SEQ ID
NO: 1009, SEQ ID NO: 1010, SEQ ID NO: 1011, SEQ ID NO: 1012, SEQ ID
NO: 1013, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1016, SEQ ID
NO:1017, SEQ ID NO:1018, SEQ ID NO:1019, SEQ ID NO:1020, SEQ ID
NO: 1021, SEQ ID NO: 1022, SEQ ID NO: 1023, SEQ ID NO: 1024, SEQ ID
NO:1025, SEQ ID NO:1026, SEQ ID NO:1027, SEQ ID NO:1028, SEQ ID
NO: 1029, SEQ ID NO: 1030, SEQ ID NO: 1031, SEQ ID NO: 1032, SEQ ID
NO: 1033, SEQ ID NO: 1034, SEQ ID NO: 1035, SEQ ID NO: 1036, SEQ ID
NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1039, SEQ ID NO: 1040, SEQ ID
NO: 1041, SEQ ID NO: 1042, SEQ ID NO: 1043, SEQ ID NO: 1044, SEQ ID
NO:1045, SEQ ID NO:1046, SEQ ID NO:1047, SEQ ID NO:1048, SEQ ID
NO: 1049, SEQ ID NO: 1050, SEQ ID NO: 1051, SEQ ID NO: 1052, SEQ ID
NO: 1053, SEQ ID NO: 1054, SEQ ID NO: 1055, SEQ ID NO: 1056, SEQ ID

604

WO 98/45437

PCT/US98/06956

NO: 1057, SEQ ID NO: 1058, SEQ ID
NO: 1061, SEQ ID NO: 1062, SEQ ID
NO: 1065, SEQ ID NO: 1066, SEQ ID
NO: 1069, SEQ ID NO: 1070, SEQ ID
NO: 1073, SEQ ID NO: 1074, SEQ ID
NO: 1077, SEQ ID NO: 1078, SEQ ID
NO: 108 1, SEQ ID NO: 1082, SEQ ID
NO: 1085, SEQ ID NO: 1086, SEQ ID
NO: 1089, SEQ ID NO: 1090, SEQ ID
NO: 1093, SEQ ID NO: 1094, SEQ ID
NO: 1097, SEQ ID NO: 1098, SEQ ID
NO: 1101, SEQ ID NO: 1 102, SEQ ID
NO. 1105, SEQ ID NO: 1106, SEQ ID
NO: 1109, SEQ ID NO: 11 10, SEQ ID
NO: 11 13, SEQ ID NO: 11 14, SEQ ID
NO: 11 17, SEQ ID NO: 11 18, SEQ ID
NO: 1121, SEQ ID NO: 1122, SEQ ID
NO: 1125, SEQ ID NO: 1126, SEQ ID
NO: 1129, SEQ ID NO: 1130, SEQ ID
NO: 1133, SEQ ID N0.1134, SEQ ID
NO: 1137, SEQ ID NO: 1138, SEQ ID
NO: 1141, SEQ ID NO: 1142, SEQ ID
NO: 1145, SEQ ID NO: 1146, SEQ ID
NO: 1149, SEQ ID NO: 1150, SEQ ID
NO: 1153, SEQ ID NO: 1154, SEQ ID
NO: 1157, SEQ ID NO: 1158, SEQ ID
NO:1161, SEQ ID NO:1162, SEQ ID
NO:1165, SEQ ID NO:1166, SEQ ID
NO: 1169, SEQ ID NO: 1170, SEQ ID
NO: 1173, SEQ ID NO: 1174, SEQ ID
NO: 1 177, SEQ ID NO: 1178, SEQ ID
NO:1181, SEQ ID NO:1182, SEQ ID
NO: 1185, SEQ ID NO: 1186, SEQ ID
NO: 1189, SEQ ID NO: 1190, SEQ ID

NO: 1059, SEQ ID NO: 1060, SEQ ID
NO: 1063, SEQ ID NOA064, SEQ ID
NO: 1067, SEQ ID NO: 1068, SEQ ID
NO:1071, SEQ ID NO.1072, SEQ ID
NO: 1075, SEQ ID NO: 1076, SEQ ID
NO: 1079, SEQ ID NO: 1080, SEQ ID
NO: 1083, SEQ ID NO: 1084, SEQ ID
NO: 1087, SEQ ID NO: 1088, SEQ ID
NO: 1091, SEQ ID NO: 1092, SEQ ID
NO: 1095, SEQ ID NO: 1096, SEQ ID
NO: 1099, SEQ ID NO: 1100, SEQ ID
NO:1103, SEQ ID NO:1104, SEQ ID
NO: 1107, SEQ ID NO: 1108, SEQ ID
NO: 11 11, SEQ ID NO:1112, SEQ ID
NO: 11 15, SEQ ID NO: 11 16, SEQ ID
NO: 11 19, SEQ ID NO: 1120, SEQ ID
NO: 1123, SEQ ID NO: 1124, SEQ ID
NO: 1127, SEQ ID NO: 1128, SEQ ID
NO: 1131, SEQ ID NO: 1132, SEQ ID
NO: 1135, SEQ ID NO: 1136, SEQ ID
NO: 1139, SEQ ID NO: 1140, SEQ ID
NO: 1143, SEQ ID NO: 1144, SEQ ID
NO: 1147, SEQ ID NO: 1148, SEQ ID
NO: 1151, SEQ ID NO: 1152, SEQ ID
NO: 1155, SEQ ID NO: 1156, SEQ ID
NO: 1159, SEQ ID NO: 1160, SEQ ID
NO: 1163, SEQ ID NO:1164, SEQ ID
NO: 1167, SEQ ID NO: 1168, SEQ ID
NO: 1171, SEQ ID NO: 1172, SEQ ID
NO: 1175, SEQ ID NO: 1176, SEQ ID
NO: 1179, SEQ ID NO: 1180, SEQ ID
NO: 1183, SEQ ID NO: 11 84, SEQ ID
NO: 1187, SEQ ID NO: 11 88, SEQ ID
NO: 1191, SEQ ID NO: 1192, SEQ ID

605

WO 98/45437

PCTYUS98/06956

NO: 1193, SEQ ID NO: 1194, SEQ ID
NO: 1197, SEQ ID NO: 1198. SEQ ID
NO: 1201, SEQ ID NO: 1202, SEQ ID
NO: 1205, SEQ ID NO: 1206, SEQ ID
NO: 1209, SEQ ID NO: 1210, SEQ ID
NO: 1213, SEQ ID NO: 1214, SEQ ID
NO:1217, SEQ ID NO:1218, SEQ ID
NO: 1221, SEQ ID NO: 1222, SEQ ID
NO: 1225, SEQ ID NO: 1226, SEQ ID
NO: 1229, SEQ ID NO: 1230, SEQ ID
NO: 1233, SEQ ID NO: 1234, SEQ ID
NO: 1237, SEQ ID NO: 1238, SEQ ID
NO: 1241, SEQ ID NO: 1242, SEQ ID
NO: 1245, SEQ ID NO: 1246, SEQ ID
NO: 1249, SEQ ID NO: 1250, SEQ ID
NO: 1253, SEQ ID NO: 1254, SEQ ID
NO: 1257, SEQ ID NO: 1258, SEQ ID
NO: 1261, SEQ ID NO: 1262, SEQ ID
NO: 1265, SEQ ID NO: 1266, SEQ ID
NO.-1269, SEQ ID NO: 1270, SEQ ID
NO: 1273, SEQ ID NO: 1274, SEQ ID
NO: 1277, SEQ ID NO: 1278, SEQ ID
NO:1281, SEQ ID NO: 1282, SEQ ID
NO: 1285, SEQ ID NO: 1286, SEQ ID
NO:1289, SEQ ID NO: 1290, SEQ ID
NO: 1293, SEQ ID NO: 1294, SEQ ID
NO: 1297, SEQ ID NO: 1298, SEQ ID
NO:1301, SEQ ID NO:1302, SEQ ID
NO: 1305, SEQ ID NO: 1306, SEQ ID
NO: 1309, SEQ ID NO: 13 10, SEQ ID
NO:1313, SEQ ID NO:1314, SEQ ID
NO: 1317, SEQ ID NO: 1318, SEQ ID
NO: 1321, SEQ ID NO: 1322, SEQ ID
NO: 1325, SEQ ID NO: 1326, SEQ ID

NO: 1195, SEQ ID NO: 1196, SEQ ID
NO: 1199, SEQ ID NO: 1200, SEQ ID
NO: 1203, SEQ ID NO: 1204, SEQ ID
NO: 1207, SEQ ID NO: 1208, SEQ ID
NO:1211, SEQ ID NO:1212, SEQ ID
NO:12l5, SEQ ID NO:1216, SEQ ID
NO: 1219, SEQ ID NO: 1220, SEQ ID
NO: 1223, SEQ ID NO: 1224, SEQ ID
NO: 1227, SEQ ID NO: 1228, SEQ ID
NO: 1231, SEQ ID NO: 1232, SEQ ID
NO: 1235, SEQ ID NO: 1236, SEQ ID
NO: 1239, SEQ ID NO: 1240, SEQ ID
NO: 1243, SEQ ID NO: 1244, SEQ ID
NO: 1247, SEQ ID NO: 1248, SEQ ID
NO: 1251, SEQ ID NO:1252, SEQ ID
NO: 1255, SEQ ID NO: 1256, SEQ ID
NO:! 259, SEQ ID NO: 1260, SEQ ID
NO: 1263, SEQ ID NO: 1264, SEQ ID
NO: 1267, SEQ ID NO: 1268, SEQ ID
NO: 1271, SEQ ID NO: 1272, SEQ ID
NO: 1275, SEQ ID NO: 1276, SEQ ID
NO: 1279, SEQ ID NO: 1280, SEQ ID
NO: 1283, SEQ ID NO: 1284, SEQ ID
NO: 1287, SEQ ID NO: 1288, SEQ ID
NO:1291, SEQ ID NO:1292, SEQ ID
NO: 1295, SEQ ID NO: 1296, SEQ ID
NO:1299, SEQ ID NO: 1300, SEQ ID
NO: 1303, SEQ ID NO: 1304, SEQ ID
NO: 1307, SEQ ID NO: 1308, SEQ ID
NO:1311, SEQ ID NO:1312, SEQ ID
NO:1315, SEQ ID NO:1316, SEQ ID
NO:1319, SEQ ID NO:1320, SEQ ID
NO: 1323, SEQ ID NO: 1324, SEQ ID
NO: 1327, SEQ ID NO: 1328, SEQ ID

606

WO 98/45437

PCT/US98/06956

NO: 1329, SEQ ID NO: 1330, SEQ ID
NO: 1333, SEQ ID NO: 1334, SEQ ID
NO: 1337, SEQ ID NO: 1338, SEQ ID
NO: 1341, SEQ ID NO: 1342, SEQ ID
NO: 1345. SEQ ID NO: 1346, SEQ ID
NO: 1349, SEQ ID NO: 1350, SEQ ID
NO: 1353, SEQ ID NO: 1354, SEQ ID
NO: 1357, SEQ ID NO: 1358, SEQ ID
NO: 1361, SEQ ID NO: 1362, SEQ ID
NO: 1365, SEQ ID NO: 1366, SEQ ID
NO: 1369, SEQ ID NO: 1370, SEQ ID
NO: 1373, SEQ ID NO: 1374, SEQ ID
NO: 1377, SEQ ID NO: 1378, SEQ ID
NO:1381, SEQ ID NO:1382, SEQ ID
NO: 1385, SEQ ID NO: 1386, SEQ ID
NO: 1389, SEQ ID NO: 1390, SEQ ID
NO: 1393, SEQ ID NO: 1394, SEQ ID
NO: 1397, SEQ ID NO: 1398, SEQ ID
NO: 1401, SEQ ID NO: 1402, SEQ ID
NO: 1405, SEQ ID NO: 1406, SEQ ID
NO: 1409, SEQ ID NO: 1410, SEQ ID
NO: 1413, SEQ ID NO: 1414, SEQ ID
NO: 1417, SEQ ID NO: 1418, SEQ ID
NO: 1421, SEQ ID NO:1422, SEQ ID
NO: 1425, SEQ ID NO: 1426, SEQ ID
NO: 1429, SEQ ID NO: 1430, SEQ ID
NO:.1433, SEQ ID NO: 1434, SEQ ID
NO: 1437, SEQ ID NO: 1438, SEQ ID
NO: 1441, SEQ ID NO: 1442, SEQ ID
NO: 1445, SEQ ID NO: 1446, SEQ ID
NO: 1449, SEQ ID NO: 1450, SEQ ID
NO: 1453, SEQ ID NO: 1454, SEQ ID
NO: 1457, SEQ ID NO: 1458, SEQ ID
NO: 1461, SEQ ID NO: 1462, SEQ ID

NO:1331, SEQ ID NO:1332, SEQ ID
NO: 1335, SEQ ID NO: 1336, SEQ ID
NO: 1339, SEQ ID NO: 1340, SEQ ID
NO: 1343, SEQ ID NO: 1344, SEQ ID
NO: 1347, SEQ ID NO: 1348, SEQ ID
NO: 1351, SEQ ID NO: 1352, SEQ ID
NO: 1355, SEQ ID NO: 1356, SEQ ID
NO: 1359, SEQ ID NO:1360, SEQ ID
NO: 1363, SEQ ID NO: 1364, SEQ ID
NO: 1367, SEQ ID NO: 1368, SEQ ID
NO: 1371, SEQ ID NO: 1372, SEQ ID
NO: 1375, SEQ ID NO: 1376, SEQ ID
NO: 1379, SEQ ID NO: 1380, SEQ ID
NO: 1383, SEQ ID NO: 1384, SEQ ID
NO: 1387, SEQ ID NO: 1388, SEQ ID
NO: 1391, SEQ ID NO: 1392, SEQ ID
NO: 1395, SEQ ID NO: 1396, SEQ ID
NO: 1399, SEQ ID NO: 1400, SEQ ID
NO: 1403, SEQ ID NO: 1404, SEQ ID
NO: 1407, SEQ ID NO: 1408, SEQ ID
NO: 14 11, SEQ ID NO: 1412, SEQ ID
NO:1415, SEQ ID NO:1416, SEQ ID
NO: 1419, SEQ ID NO: 1420, SEQ ID
NO: 1423, SEQ ID NO: 1424, SEQ ID
NO: 1427, SEQ ID NO: 1428, SEQ ID
NO: 1431, SEQ ID NO: 1432, SEQ ID
NO:1435, SEQ ID NO: 1436, SEQ ID
NO: 1439, SEQ ID NO: 1440, SEQ ID
NO: 1443, SEQ ID NO: 1444, SEQ ID
NO: 1447, SEQ ID NO: 1448, SEQ ID
NO: 1451, SEQ ID NO: 1452, SEQ ID
NO: 1455, SEQ ID NO: 1456, SEQ ID
NO: 1459, SEQ ID NO: 1460, SEQ ID
NO: 1463, SEQ ID NO: 1464, SEQ ID

607

WO 98/45437

PCT/US98/06956

NO: 1465, SEQ ID NO: 1466, SEQ ID NO: 1467, SEQ ID NO: 1468, SEQ ID
NO: 1469, SEQ ID NO: 1470, SEQ ID NO: 1471, SEQ ID NO: 1472, SEQ ID
NO: 1473, SEQ ID NO: 1474, SEQ ID NO: 1475, SEQ ID NO: 1476, SEQ ID
NO: 1477, SEQ ID NO: 1478, SEQ ID NO: 1479, SEQ ID NO: 1480, SEQ ID
NO: 1481, SEQ ID NO:1482, SEQ ID NO:1483, SEQ ID NO:1484, SEQ ID
NO: 1485, SEQ ID NO: 1486, SEQ ID NO: 1487, SEQ ID NO: 1488, SEQ ID
NO: 1489, SEQ ID NO: 1490, SEQ ID NO: 1491, SEQ ID NO: 1492, SEQ ID
NO: 1493, SEQ ID NO: 1494, SEQ ID NO: 1495, SEQ ID NO: 1496, SEQ ID
NO: 1497, SEQ ID NO: 1498, SEQ ID NO: 1499, SEQ ID NO: 1500, SEQ ID
NO: 1501, SEQ ID NO: 1502, SEQ ID NO: 1503, SEQ ID NO: 1504, SEQ ID
NO: 1505, SEQ ID NO: 1506, SEQ ID NO: 1507, SEQ ID NO: 1508, SEQ ID
NO: 1509, SEQ ID NO: 1510, SEQ ID NO: 1511, SEQ ID NO: 1512, SEQ ID
NO: 1513, SEQ ID NO:1514, SEQ ID NO:1515, SEQ ID NO:1516, SEQ ID
NO: 1517, SEQ ID NO:1518, and SEQ ID NO:1519;
or a complement of said sequence.

2 . An isolated polynucleotide consisting of a nucleotide sequence selected from
the group consisting of:

SEQ ID NO:l, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ
ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO: 10, SEQ ID
NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ
ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO:20, SEQ
ID NO:21 , SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ
ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ
ID NO: 31, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ
ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ
ID NO:41 , SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ
ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ
ID NO:51, SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ
ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ
ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ
ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ
ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ
ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ

608

WO 98/45437

PCTYUS98/06956

ID NO:81 , SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ
ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90. SEQ
ID NO:91 , SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ
ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO: 100,
SEQ ID NO:101, SEQ ID NO:102, SEQ ID NO:103, SEQ ID NO:104, SEQ ID
NO: 105, SEQ ID NO; 106, SEQ ID NO: 107, SEQ ID NO: 108, SEQ ID NO: 109,
SEQ ID NO: 1 10, SEQ ID NO: 111, SEQ ID NO: 112, SEQ ID NO: 113, SEQ ID
NO: 114, SEQ ID NO: 115, SEQ ID NO: 116, SEQ ID NO: 117, SEQ ID NO: 118,
SEQ ID NO: 119, SEQ ID NO: 120, SEQ ID NO: 121, SEQ ID NO: 122, SEQ ID
NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 127,
SEQ ID NO: 128, SEQ ID NO: 129, SEQ ID NO: 130, SEQ ID NO: 131, SEQ ID
NO: 132, SEQ ID NO: 133, SEQ ID NO: 134, SEQ ID NO: 135, SEQ ID NO: 136,
SEQ ID NO: 137, SEQ ID NO: 138, SEQ ID NO: 139, SEQ ID NO: 140, SEQ ID
NO: 141, SEQ ID NO: 142, SEQ ID NO: 143, SEQ ID NO: 144, SEQ ID NO: 145,
SEQ ID NO: 146, SEQ ID NO: 147, SEQ ID NO: 148, SEQ ID NO: 149, SEQ ID
NO: 150, SEQ ID NO: 151, SEQ ID NO: 152, SEQ ID NO: 153, SEQ ID NO: 154,
SEQ ID NO: 155, SEQ ID NO: 156, SEQ ID NO: 157, SEQ ID NO: 158, SEQ ID
NO: 159, SEQ ID NO: 160, SEQ ID NO: 161, SEQ ID NO: 162, SEQ ID NO: 163,
SEQ ID NO: 164, SEQ ID NO: 165, SEQ ID NO: 166, SEQ ID NO: 167, SEQ ID
NO: 168, SEQ ID NO: 169, SEQ ID NO: 170, SEQ ID NO: 171, SEQ ID NO: 172,
SEQ ID NO: 173, SEQ ID NO: 174, SEQ ID NO: 175, SEQ ID NO: 176, SEQ ID
NO: 177, SEQ ID NO: 178, SEQ ID NO: 179, SEQ ID NO: 180, SEQ ID NO: 181,
SEQ ID NO: 182, SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO: 185, SEQ ID
NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, SEQ ID NO: 189, SEQ ID NO: 190,
SEQ ID NO:191, SEQ ID NO:192, SEQ ID NO:193, SEQ ID NO:194, SEQ ID
NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199,
SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID
NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208,
SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:211, SEQ ID NO:212, SEQ ID
NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217,
SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID
NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226,
SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID
NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235,

609

WO 98/45437

PCT/US98/06956

SEQ ID NO:236, SEQ ID NO:237> SEQ ID NO:238, SEQ ID NO:239, SEQ ID
NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244,
SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:247, SEQ ID NO:248, SEQ ID
NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253,
SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID
NO:258, SEQ ID NO:259, SEQ ID NO;260, SEQ ID NO:26h SEQ ID NO:262,
SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID
NO:267, SEQ ID NO:268, SEQ ID NO:269 T SEQ ID NO:270, SEQ ID NO:27l,
SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275, SEQ ID
NO:276, SEQ ID NO:277 t SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280,
SEQ ID NO:281, SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID
NO:285, SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289,
SEQ ID NO;290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID NO:293 t SEQ ID
NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298,
SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO:301, SEQ ID NO:302, SEQ ID
NO:303, SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307,
SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:3IO, SEQ ID NO:311, SEQ ID
NO:312, SEQ ID NO:313, SEQ ID NOI314, SEQ ID NO:315 > SEQ ID NO:316,
SEQ ID NO:317, SEQ ID NO:3l8, SEQ ID NO:3I9, SEQ ID NO:320, SEQ ID
NO:321, SEQ ID NO:322, SEQ ID NO:323, SEQ ID NO:324, SEQ ID NO:325,
SEQ ID NO:326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID
NO:330, SEQ ID NO:331, SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334,
SEQ ID NO.335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO:338, SEQ ID
NO:339, SEQ ID NO:340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO:343,
SEQ ID NO:344, SEQ ID NO:345 > SEQ ID NO:346, SEQ ID NO:347, SEQ ID
NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352,
SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356, SEQ ID
NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO:360, SEQ ID NO:361,
SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID
NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369, SEQ ID NO:370 T
SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373, SEQ ID NO:374, SEQ ID
NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379,
SEQ ID NO;380, SEQ ID NO:381, SEQ ID NO:382, SEQ ID NO:383, SEQ ID
NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388,

610

WO 98/45437

PCT/US98/06956

SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID
NO:393, SEQ ID NO:394, SEQ ID NO;395, SEQ ID NO:396, SEQ ID NO:397,
SEQ ID NO:398, SEQ ID NO:399, SEQ ID NO:400, SEQ ID NO:401, SEQ ID
NO:402 t SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406,
SEQ ID NO:407. SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410, SEQ ID
NO;411, SEQ ID NO:4l2, SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415,
SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418, SEQ ID NO:419, SEQ ID
NO:420 T SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424,
SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428, SEQ ID
NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433,
SEQ ID NO:434, SEQ ID NO:435, SEQ ID NO:436, SEQ ID NO:437, SEQ ID
NO:438 t SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO.441, SEQ ID NO:442,
SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446> SEQ ID
NO:447, SEQ ID NO:448 T SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451,
SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO;454, SEQ ID NO:455, SEQ ID
NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO:459, SEQ ID NO:460,
SEQ ID NO:461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO:464, SEQ ID
NO:465 t SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469,
SEQ ID NO:470, SEQ ID NO:471 7 SEQ ID NO:472 t SEQ ID NO:473, SEQ ID
NO:474, SEQ ID NO:475, SEQ ID NO:476, SEQ ID NO:477, SEQ ID NO:478,
SEQ ID NO:479, SEQ ID NO:480, SEQ ID NO:481, SEQ ID NO:482, SEQ ID
NO:483, SEQ ID NO:484, SEQ ID NO:485, SEQ ID NO:486, SEQ ID NO:487,
SEQ ID NO:488, SEQ ID NO:489, SEQ ID NO:490, SEQ ID NO:491, SEQ ID
NO:492, SEQ ID NO:493, SEQ ID NO:494, SEQ ID NO:495, SEQ ID NO:496,
SEQ ID NO:497, SEQ ID NO:498, SEQ ID NO:499, SEQ ID NO:500, SEQ ID
NO:501, SEQ ID NO:502, SEQ ID NO:503, SEQ ID NO:504, SEQ ID NO:505,
SEQ ID NO:506, SEQ ID NO:507, SEQ ID NO:508, SEQ ID NO:509, SEQ ID
NO:510, SEQ ID NO:51 1, SEQ ID NO:512, SEQ ID N0:513, SEQ ID NO:514,
SEQ ID NO:515, SEQ ID NO:516, SEQ ID NO:517, SEQ ID NO:518, SEQ ID
NO:519, SEQ ID NO:520, SEQ ID NO:52U SEQ ID NO:522, SEQ ID NO:523,
SEQ ID NO:524, SEQ ID NO:525, SEQ ID NO:526, SEQ ID NO:527, SEQ ID
NO:528, SEQ ID NO:529, SEQ ID NO:530, SEQ ID NO:531, SEQ ID NO:532,
SEQ ID NO:533, SEQ ID NO:534 T SEQ ID NO:535, SEQ ID NO:536, SEQ ID
NO:537, SEQ ID NO:538, SEQ ID NO:539, SEQ ID NO:540, SEQ ID NO:541,

611

WO 98/45437

PCT/US98/06956

SEQ ID NO:542, SEQ ID NO:543, SEQ ID NO:544, SEQ ID NO:545, SEQ ID
NO:546, SEQ ID NO:547, SEQ ID NO:548, SEQ ID NO:549, SEQ ID NO:550,
SEQ ID NO:55U SEQ ID NO:552, SEQ ID NO:553, SEQ ID NO:554, SEQ ID
NO:555, SEQ ID NO:556, SEQ ID NO:557, SEQ ID NO:558, SEQ ID NO:559,
SEQ ID NO:560, SEQ ID NO:561, SEQ ID NO:562, SEQ ID NO:563, SEQ ID
NO:564, SEQ ID NO:565, SEQ ID NO:566, SEQ ID NO:567, SEQ ID NO:568,
SEQ ID NO:569, SEQ ID NO:570, SEQ ID NO:57I, SEQ ID NO:572, SEQ ID
NO:573, SEQ ID NO:574, SEQ ID NO:575, SEQ ID NO:576, SEQ ID NO:577,
SEQ ID NO:578, SEQ ID NO:579, SEQ ID NO:580, SEQ ID NO:581, SEQ ID
NO:582, SEQ ID NO;583, SEQ ID NO:584, SEQ ID NO:585, SEQ ID NO:586,
SEQ ID NO:587, SEQ ID NO:588, SEQ ID NO:589, SEQ ID NO:590, SEQ ID
NO:591, SEQ ID NO:592, SEQ ID NO:593> SEQ ID NO:594 t SEQ ID NO:595 t
SEQ ID NO:596, SEQ ID NO:597, SEQ ID NO;598, SEQ ID NO:599, SEQ ID
NO:600, SEQ ID NO:601, SEQ ID NO:602, SEQ ID NO:603, SEQ ID NO:604,
SEQ ID NO:605, SEQ ID 1^0:606, SEQ ID NO:607, SEQ ID NO:608, SEQ ID
NO:609, SEQ ID NO:610, SEQ ID NO:61 1, SEQ ID NO:612, SEQ ID NO:613,
SEQ ID NO:614, SEQ ID NO:615, SEQ ID NO:6l6, SEQ ID NO:617, SEQ ID
NO:618, SEQ ID NO:619, SEQ ID NO:620, SEQ ID NO:621, SEQ ID NO:622,
SEQ ID NO:623, SEQ ID NO:624, SEQ ID NO:625, SEQ ID NO:626, SEQ ID
NO:627, SEQ ID NO:628 t SEQ ID NO:629, SEQ ID NO:630, SEQ ID NO:631,
SEQ ID NO:632, SEQ ID NO:633, SEQ ID NO:634, SEQ ID NO:635, SEQ ID
NO:636, SEQ ID NO:637, SEQ ID NO:638, SEQ ID NO:639, SEQ ID NO:640,
SEQ ID NO:641, SEQ ID NO:642, SEQ ID NO:643, SEQ ID NO:644, SEQ ID
NO:645 T SEQ ID NO:646, SEQ ID NO:647, SEQ ID NO:648, SEQ ID NO:649 T
SEQ ID NO:650, SEQ ID NO:651, SEQ ID NO:652, SEQ ID NO:653> SEQ ID
NO:654, SEQ ID NO:655, SEQ ID NO:656, SEQ ID NO:657, SEQ ID NO:658,
SEQ ID NO:659, SEQ ID NO:660, SEQ ID NO:661, SEQ ID NO:662, SEQ ID
NO:663, SEQ ID NO:664, SEQ ID NO:665, SEQ ID NO:666 T SEQ ID NO:667,
SEQ ID NO:668, SEQ ID NO:669, SEQ ID NO:670, SEQ ID NO:671, SEQ ID
NO:672, SEQ ID NO:673, SEQ ID NO:674, SEQ ID NO:675, SEQ ID NO:676 >
SEQ ID NO:677, SEQ ID NO:678, SEQ ID NO:679, SEQ ID NO:680 T SEQ ID
NO:681, SEQ ID NO:682, SEQ ID NO:683, SEQ ID NO:684, SEQ ID NO:685>
SEQ ID NO:686, SEQ ID NO:687, SEQ ID NO:688, SEQ ID NO:689, SEQ ID
NO:690, SEQ ID NO:691, SEQ ID NO:692, SEQ ID NO:693, SEQ ID NO:694,

612

I

WO 98/45437

PCT/US98/06956

SEQ ID NO:695, SEQ ID NO:696, SEQ ID NO:697, SEQ ID NO:698, SEQ ID
NO:699, SEQ ID NO:700, SEQ ID NO:70l, SEQ ID NO:702, SEQ ID NO:703,
SEQ ID NO:704. SEQ ID NO:705, SEQ ID NO:706. SEQ ID NOI707, SEQ ID
NO:708, SEQ ID NO:709, SEQ ID NO:710, SEQ ID NO:71 1, SEQ ID NO:712,
SEQ ID NO:713, SEQ ID NO:714, SEQ ID NO:715, SEQ ID NO:716, SEQ ID
NO:717, SEQ ID NO:718, SEQ ID NO:719, SEQ ID NO:720, SEQ ID NO:721,
SEQ ID NO:722, SEQ ID NO:723, SEQ ID NO:724, SEQ ID NO:725, SEQ ID
NO:726, SEQ ID NO:727, SEQ ID NO:728, SEQ ID NO:729, SEQ ID NO:730,
SEQ ID NO:731, SEQ ID NO:732, SEQ ID NO:733, SEQ ID NO:734, SEQ ID
NO:735, SEQ ID NO:736, SEQ ID NO:737, SEQ ID NO:738, SEQ ID NO:739,
SEQ ID NO:740, SEQ ID NO:741, SEQ ID NO:742, SEQ ID NO:743, SEQ ID
NO:744, SEQ ID NO:745, SEQ ID NO:746, SEQ ID NO:747, SEQ ID NO:748,
SEQ ID NO:749, SEQ ID NO:750, SEQ ID NO:751, SEQ ID NO;752, SEQ ID
NO:753, SEQ ID NO:754, SEQ ID NO:755, SEQ ID 140:756, SEQ ID NO:757,
SEQ ID NO:758, SEQ ID NO:759, SEQ ID NO:760, SEQ ID NO:761, SEQ ID
NO:762, SEQ ID NO:763, SEQ ID NO:764, SEQ ID NO:765, SEQ ID NO:766 1
SEQ ID NO:767, SEQ ID NO:768, SEQ ID NO:769, SEQ ID NO:770, SEQ ID
NO:771, SEQ ID NO:772, SEQ ID NO:773, SEQ ID NO:774, SEQ ID NO:775,
SEQ ID NO:776, SEQ ID NO:777, SEQ ID NO:778, SEQ ID NO:779, SEQ ID
NO:780, SEQ ID NO:781, SEQ ID NO:782, SEQ ID NO:783, SEQ ID NO:784,
SEQ ID NO:785, SEQ ID NO:786, SEQ ID NO:787, SEQ ID NO:788, SEQ ID
NO:789, SEQ ID NO;790, SEQ ID NO:791, SEQ ID NO:792, SEQ ID NO:793,
SEQ ID NO:794, SEQ ID NO:795, SEQ ID NO:796, SEQ ID NO:797, SEQ ID
NO:798, SEQ ID NO:799, SEQ ID NO:800, SEQ ID NO:801, SEQ ID NO:802,
SEQ ID NO:803, SEQ ID NO:804, SEQ ID NO:805, SEQ ID NO:806, SEQ ID
NO:807, SEQ ID NO:808, SEQ ID NO:809, SEQ ID NO:810, SEQ ID NO:81 1,
SEQ ID NO:812, SEQ ID NO:813, SEQ ID NO:814, SEQ ID NO:815, SEQ ID
NO:816, SEQ ID NO:817, SEQ ID NO:818, SEQ ID NO:819, SEQ ID NO:820,
SEQ ID NO:821, SEQ ID NO:822, SEQ ID NO:823, SEQ ID NO:824, SEQ ID
NO:825, SEQ ID NO:826, SEQ ID NO:827, SEQ ID NO:828, SEQ ID NO:829,
SEQ ID NO:830, SEQ ID NO:831, SEQ ID NO:832, SEQ ID NO:833, SEQ ID
NO:834 T SEQ ID NO:835, SEQ ID NO:836, SEQ ID NO:837, SEQ ID NO:838,
SEQ ID NO:839, SEQ ID NO:840, SEQ ID NO:841, SEQ ID NO:842, SEQ ID
NO:843, SEQ ID NO:844, SEQ ID NO:845 > SEQ ID NO:846, SEQ ID NO:847,

613

WO 98/45437

PCT/US98/06956

SEQ ID NO:848, SEQ ID NO:849, SEQ ID NO:850, SEQ ID NO:851, SEQ ID
NO:852, SEQ ID NO:853, SEQ ID NO:854, SEQ ID NO:855. SEQ ID NO:856,
SEQ ID NO:857, SEQ ID NO:858, SEQ ID NO:859, SEQ ID NO:860, SEQ ID
NO:86i, SEQ ID NO:862, SEQ ID NO:863, SEQ ID NO:864, SEQ ID NO:865,
SEQ ID NO:866. SEQ ID NO:867, SEQ ID NO:868. SEQ ID NO:869 > SEQ ID
NO:870, SEQ ID NO:871, SEQ ID NO: 872, SEQ ID NO:873, SEQ ID NO:874,
SEQ ID NO:875, SEQ ID NO:876, SEQ ID NO:877, SEQ ID NO;878, SEQ ID
NO:879, SEQ ID NO:880, SEQ ID NO:881, SEQ ID NO:882, SEQ ID NO:883,
SEQ ID NO:884, SEQ ID NO:885, SEQ ID NO:886, SEQ ID NO:887, SEQ ID
NO:888, SEQ ID NO:889, SEQ ID NO:890, SEQ ID NO:891, SEQ ID NO:892,
SEQ ID NO:893 T SEQ ID NO:894, SEQ ID NO:895, SEQ ID NO:896, SEQ ID
NO:897, SEQ ID NO:898, SEQ ID NO: 899, SEQ ID NO:900, SEQ ID NO:901,
SEQ ID NO:902, SEQ ID NO:903, SEQ ID NO:904, SEQ ID NO:905, SEQ ID
NO:906, SEQ ID NO:907, SEQ ID NO:908 T SEQ ID NO:909, SEQ ID NO:910,
SEQ ID NO-.911, SEQ ID NO:9I2, SEQ ID NO:913, SEQ ID NO:914, SEQ ID
NO:915, SEQ ID NO:916, SEQ ID NO:917, SEQ ID NO:918, SEQ ID NO: 9 19,
SEQ ID NO:920, SEQ ID NO:921, SEQ ID NO:922, SEQ ID NO:923, SEQ ID
NO:924, SEQ ID NO:925, SEQ ID NO:926, SEQ ID NO:927, SEQ ID NO:928,
SEQ ID NO:929, SEQ ID NO:930> SEQ ID NO:931, SEQ ID NO:932, SEQ ID
NO:933, SEQ ID NO:934, SEQ ID NO:935, SEQ ID NO:936, SEQ ID NO:937,
SEQ ID NO:938, SEQ ID NO:939, SEQ ID NO:940, SEQ ID NO:941, SEQ ID
NO:942, SEQ ID NO:943, SEQ ID NO:944, SEQ ID NO:945, SEQ ID NO:946,
SEQ ID NO:947, SEQ ID NO:948, SEQ ID NO;949, SEQ ID NO:950, SEQ ID
NO:951, SEQ ID NO:952, SEQ ID NO:953, SEQ ID NO:954, SEQ ID NO:955,
SEQ ID NO:956, SEQ ID NO:957, SEQ ID NO:958, SEQ ID NO:959, SEQ ID
NO:960, SEQ ID NO:961, SEQ ID NO:962, SEQ ID NO:963, SEQ ID NO:964,
SEQ ID NO:965, SEQ ID NO:966, SEQ ID NO:967, SEQ ID NO:968, SEQ ID
NO:969, SEQ ID NO:970, SEQ ID NO:971, SEQ ID NO:972, SEQ ID NO:973,
SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:976, SEQ ID N0.977, SEQ ID
NO:978, SEQ ID NO:979, SEQ ID NO:980, SEQ ID NO:981, SEQ ID NO:982,
SEQ ID NO:983, SEQ ID NO:984, SEQ ID NO.985, SEQ ID NO:986, SEQ ID
NO:987, SEQ ID NO:988, SEQ ID NO:989, SEQ ID NO:990, SEQ ID NO:991,
SEQ ID NO:992, SEQ ID NO:993, SEQ ID NO:994, SEQ ID NO:995, SEQ ID
NO:996, SEQ ID NO:997, SEQ ID NO:998, SEQ ID NO:999, SEQ ID NO: 1000,

614

WO 98/45437

PCT/US98/06956

SEQ ID NO: 1001, SEQ ID NO: 1002, SEQ ID NO: 1003, SEQ ID NO: 1004, SEQ
ID NO: 1005, SEQ ID NO: 1006, SEQ ID NO: 1007, SEQ ID NO: 1008, SEQ ID
NO: 1009, SEQ ID NO: 1010, SEQ ID NO: 1011, SEQ ID NO: 1012, SEQ ID
NO: 1013, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1016, SEQ ID
NO: 1017, SEQ ID NO: 1018, SEQ ID NO: 1019, SEQ ID NO: 1020, SEQ ID
NO: 1021, SEQ ID NO: 1022, SEQ ID NO: 1023, SEQ ID NO: 1024, SEQ ID
NO: 1025, SEQ ID NO: 1026, SEQ ID NO: 1027, SEQ ID NO: 1028, SEQ ID
NO: 1029, SEQ ID NO: 1030, SEQ ID NO: 1031, SEQ ID NO: 1032, SEQ ID
NO-.1033, SEQ ID NO:1034, SEQ ID NO:1035, SEQ ID NO: 1036, SEQ ID
NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1039, SEQ ID NO: 1040, SEQ ID
NO:1041, SEQ ID NO:1042, SEQ ID NO:1043, SEQ ID NO:1044, SEQ ID
NO: 1045, SEQ ID NO: 1046, SEQ ID NO: 1047, SEQ ID NO: 1048, SEQ ID
NO: 1049, SEQ ID NO: 1050, SEQ ID NO: 1051, SEQ ID NO: 1052, SEQ ID
NO: 1053, SEQ ID NO: 1054, SEQ ID NO: 1055, SEQ ID NO: 1056, SEQ ID
NO: 1057, SEQ ID NO: 1058, SEQ ID NO: 1059, SEQ ID NO: 1060, SEQ ID
NO: 1061, SEQ ID NO: 1062, SEQ ID NO: 1063, SEQ ID NO: 1064, SEQ ID
NO: 1065, SEQ ID NO: 1066, SEQ ID NO: 1067, SEQ ID NO: 1068, SEQ ID
NO: 1069, SEQ ID NO: 1070, SEQ ID NO: 1071, SEQ ID NO: 1072, SEQ ID
NO: 1073, SEQ ID NO: 1074, SEQ ID NO: 1075, SEQ ID NO: 1076, SEQ ID
NO: 1077, SEQ ID NO: 1078, SEQ ID NO: 1079, SEQ ID NO: 1080, SEQ ID
NO: 1081, SEQ ID NO: 1082, SEQ ID NO: 1083, SEQ ID NO: 1084, SEQ ID
NO: 1085, SEQ ID NO: 1086, SEQ ID NO: 1087, SEQ ID NO: 1088, SEQ ID
NO: 1089, SEQ ID NO: 1090, SEQ ID NO: 1091, SEQ ID NO: 1092, SEQ ID
NO: 1093, SEQ ID NO: 1094, SEQ ID NO: 1095, SEQ ID NO: 1096, SEQ ID
NO: 1097, SEQ ID NO: 1098, SEQ ID NO: 1099, SEQ ID NO: 1100, SEQ ID
NO: 1101, SEQ ID NO: 1102, SEQ ID NO: 1103, SEQ ID NO: 1104, SEQ ID
NO: 1105, SEQ ID NO: 1106, SEQ ID NO: 1107, SEQ ID NO: 1108, SEQ ID
NO: 1109, SEQ ID NO: 11 10, SEQ ID NO.llll, SEQ ID NO: 1112, SEQ ID
NO: 11 13, SEQ ID NO: 11 14, SEQ ID NO:1115, SEQ ID NO: 11 16, SEQ ID
NO: 11 17, SEQ ID NO: 11 18, SEQ ID NO: 11 19, SEQ ID NO: 1120, SEQ ID
NO: 1121, SEQ ID NO: 1122, SEQ ID NO: 1123, SEQ ID NO: 1124, SEQ ID
NO: 1125, SEQ ID NO: 1126, SEQ ID NO: 1127, SEQ ID NO: 1128, SEQ ID
NO: 1129, SEQ ID NO: 1130, SEQ ID NO: 1131, SEQ ID NO: 1132, SEQ ID
NO: 1133, SEQ ID NO: 1134, SEQ ID NO: 1135, SEQ ID NO: 1136, SEQ ID

615

WO 98/45437

PCT/US98/06956

NO:1137, SEQ ID NO:1138, SEQ ID NO: 1139,
NO:1141, SEQ ID NO: 1142, SEQ ID NO: 1 143,
NO: 1145, SEQ ID NO: 1146, SEQ ID NO: 1147,
NO: 1149, SEQ ID NO: 1150, SEQ ID NO: 1151,
NO: 1153, SEQ ID NO: 1154, SEQ ID NO: 1155,
NO: 1157, SEQ ID NO: 1158, SEQ ID NO: 1159,
NO:1161, SEQ ID NO: 1162, SEQ ID NO: 1163,
NO: 1165, SEQ ID NO: 1166, SEQ ID NO: 1167,
NO: 1169, SEQ ID NO: 1170, SEQ ID NO: 1171,
NO: 1173, SEQ ID NO: 1174, SEQ ID NO: 1175,
NO: 1177, SEQ ID NO: 1178, SEQ ID NO: 1179,
NO:1181, SEQ ID NO: 1182, SEQ ID NO: 1183,
NO: 1185, SEQ ID NO:1186, SEQ ID NO:1187,
NO.1189, SEQ ID NO: 11 90, SEQ ID NO:1191,
NO: 1193, SEQ ID NO: 1194, SEQ ID NO: 1195,
NO: 1197, SEQ ID NO: 1198, SEQ ID NO: 1199,
NO: 1201, SEQ ID NO:1202, SEQ ID NO:1203,
NO: 1205, SEQ ID NO: 1206, SEQ ID NO: 1207,
NO:1209, SEQ ID NO:1210, SEQ ID NO:1211,
NO: 1213, SEQ ID NO: 1214, SEQ ID NO: 1215,
NO:1217, SEQ ID NO:1218, SEQ ID NO:1219,
NO:1221, SEQ ID NO:1222, SEQ ID NO:1223,
NO: 1225, SEQ ID NO: 1226, SEQ ID NO: 1227,
NO: 1229, SEQ ID NO: 1230, SEQ ID NO: 1231,
NO: 1233, SEQ ID NO: 1234, SEQ ID NO: 1235,
NO: 1237, SEQ ID NO: 1238, SEQ ID NO: 1239,
NO:1241, SEQ ID NO:1242, SEQ ID NO:1243,
NO: 1245, SEQ ID NO: 1246, SEQ ID NO: 1247,
NO: 1249, SEQ ID NO: 1250, SEQ ID NO: 1251,
NO: 1253, SEQ ID NO: 1254, SEQ ID NO: 1255,
NO: 1257, SEQ ID NO: 1258, SEQ ID NO: 1259,
NO: 1261, SEQ ID NO: 1262, SEQ ID NO: 1263,
NO: 1265, SEQ ID NO: 1266, SEQ ID NO: 1267,
NO: 1269, SEQ ID NO: 1270, SEQ ID NO: 1271,

SEQ ID NO: 1140,
SEQ ID NO: 1 144,
SEQ ID NO: 1148,
SEQ ID NO: 1152,
SEQ ID NO: 1156,
SEQ ID NO: 1160,
SEQ ID NO: 11 64,
SEQ ID NO: 1168,
SEQ ID NO: 1172,
SEQ ID NO: 1 176,
SEQ ID NO: 11 80,
SEQ ID NO: 11 84,
SEQ ID NO: 1188,
SEQ ID NO: 11 92,
SEQ ID NO: 1196,
SEQ ID NO: 1200,
SEQ ID NO: 1204,
SEQ ID NO: 1208,
SEQ ID NO: 1212,
SEQ ID NO: 1216,
SEQ ID NO: 1220,
SEQ ID NO: 1224,
SEQ ID NO: 1228,
SEQ ID NO: 1232,
SEQ ID NO: 1236,
SEQ ID NO: 1240,
SEQ ID NO: 1244,
SEQ ID NO: 1248,
SEQ ID NO: 1252,
SEQ ID NO: 1256,
SEQ ID NO: 1260,
SEQ ID NO: 1264,
SEQ ID NO: 1268,
SEQ ID NO: 1272,

SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID
SEQ ID

616

WO 98/45437

PCT/US98/06956

NO: 1273, SEQ ID NO: 1274, SEQ ID
NO: 1277, SEQ ID NO: 1278, SEQ ID
NO: 1281, SEQ ID NO: 1282, SEQ ID
NO: 1285, SEQ ID NO: 1286, SEQ ID
NO: 1289, SEQ ID NO: 1290, SEQ ID
NO: 1293, SEQ ID NO: 1294, SEQ ID
NO: 1297, SEQ ID NO: 1298, SEQ ID
NO:1301, SEQ ID NO: 1302, SEQ ID
NO: 1305, SEQ ID NO: 1306, SEQ ID
NO: 1309, SEQ ID NO: 13 10, SEQ ID
NO:1313, SEQ ID NO:1314, SEQ ID
NO: 13 17, SEQ ID NO: 13 18, SEQ ID
NO: 1321, SEQ ID NO: 1322, SEQ ID
NO: 1325, SEQ ID NO: 1326, SEQ ID
NO: 1329, SEQ ID NO: 1330, SEQ ID
NO: 1333, SEQ ID NO: 1334, SEQ ID
NO: 1337, SEQ ID NO: 1338, SEQ ID
NO: 1341, SEQ ID NO: 1342, SEQ ID
NO: 1345, SEQ ID NO: 1346, SEQ ID
NO: 1349, SEQ ID NO: 1350, SEQ ID
NO: 1353, SEQ ID NO: 1354, SEQ ID
NO: 1357, SEQ ID NO: 1358, SEQ ID
NO: 1361, SEQ ID NO: 1362, SEQ ID
NO: 1365, SEQ ID NO: 1366, SEQ ID
NO: 1369, SEQ ID NO: 1370, SEQ ID
NO:1373, SEQ ID NO:1374, SEQ ID
NO: 1377, SEQ ID NO: 1378, SEQ ID
NO:1381, SEQ ID NO:1382, SEQ ID
NO: 1385, SEQ ID NO: 1386, SEQ ID
NO: 1389, SEQ ID NO: 1390, SEQ ID
NO: 1393, SEQ ID NO: 1394, SEQ ID
NO: 1397, SEQ ID NO: 1398, SEQ ID
NO: 1401, SEQ ID NO:1402, SEQ ID
NO: 1405, SEQ ID NO: 1406, SEQ ID

NO: 1275, SEQ ID NO: 1276, SEQ ID
NO: 1279. SEQ ID NO: 1280, SEQ ID
NO: 1283, SEQ ID NO: 1284, SEQ ID
NO: 1287, SEQ ID NO: 1288, SEQ ID
NO: 1291, SEQ ID NO: 1292, SEQ ID
NO: 1295, SEQ ID NO: 1296, SEQ ID
NO: 1299, SEQ ID NO: 1300, SEQ ID
NO: 1303, SEQ ID NO: 1304, SEQ ID
NO: 1307, SEQ ID NO: 1308, SEQ ID
NO: 1311, SEQ ID NO: 13 12, SEQ ID
NO:1315, SEQ ID NO: 1316, SEQ ID
NO: 1319, SEQ ID NO: 1320, SEQ ID
NO: 1323, SEQ ID NO: 1324, SEQ ID
NO: 1327, SEQ ID NO: 1328, SEQ ID
NO: 1331, SEQ ID NO:1332, SEQ ID
NO: 1335, SEQ ID NO: 1336, SEQ ID
NO: 1339, SEQ ID NO: 1340, SEQ ID
NO: 1343, SEQ ID NO: 1344, SEQ ID
NO: 1347, SEQ ID NO: 1348, SEQ ID
NO: 1351, SEQ ID NO: 1352, SEQ ID
NO:1355, SEQ ID NO:1356, SEQ ID
NO:1359, SEQ ID NO:1360, SEQ ID
NO: 1363, SEQ ID NO: 1364, SEQ ID
NO: 1367, SEQ ID NO: 1368, SEQ ID
NO:1371, SEQ ID NO:1372, SEQ ID
NO: 1375, SEQ ID NO: 1376, SEQ ID
NO:1379, SEQ ID NO:1380, SEQ ID
NO: 1383, SEQ ID NO: 1384, SEQ ID
NO: 1387, SEQ ID NO: 1388, SEQ ID
NO:1391, SEQ ID NO:1392, SEQ ID
NO: 1395, SEQ ID NO: 1396, SEQ ID
NO: 1399, SEQ ID NO: 1400, SEQ ID
NO: 1403, SEQ ID NO: 1404, SEQ ID
NO: 1407, SEQ ID NO: 1408, SEQ ID

617

WO 98/45437

PCT/US98/06956

NO:1409, SEQ ID NO:1410, SEQ ID NO:14U, SEQ ID NO:1412, SEQ ID
N0:14I3, SEQ ID NO: 1414, SEQ ID NO:1415, SEQ ID NO:1416, SEQ ID
NO: 1417, SEQ ID NO: 1418, SEQ ID NO: 1419, SEQ ID NO: 1420, SEQ ID
NO: 1421, SEQ ID NO: 1422, SEQ ID NO: 1423, SEQ ID NO: 1424, SEQ ID
NO: 1425, SEQ ID NO: 1426, SEQ ID NO: 1427, SEQ ID NO: 1428, SEQ ID
NO: 1429, SEQ ID NO: 1430, SEQ ID NO: 1431, SEQ ID NO: 1432, SEQ ID
NO: 1433, SEQ ID NO: 1434, SEQ ID NO: 1435, SEQ ID NO: 1436, SEQ ID
NO: 1437, SEQ ID NO: 1438, SEQ ID NO: 1439, SEQ ID NO: 1440, SEQ ID
NO: 1441, SEQ ID NO: 1442, SEQ ID NO: 1443, SEQ ID NO: 1444, SEQ ID
NO: 1445, SEQ ID NO: 1446, SEQ ID NO: 1447, SEQ ID NO: 1448, SEQ ID
NO: 1449, SEQ ID NO: 1450, SEQ ID NO: 1451, SEQ ID NO: 1452, SEQ ID
NO: 1453, SEQ ID NO: 1454, SEQ ID NO: 1455, SEQ ID NO: 1456, SEQ ID
NO: 1457, SEQ ID NO: 1458, SEQ ID NO: 1459, SEQ ID NO: 1460, SEQ ID
NO: 1461, SEQ ID NO: 1462, SEQ ID NO: 1463, SEQ ID NO: 1464, SEQ ID
NO: 1465, SEQ ID NO: 1466, SEQ ID NO: 1467, SEQ ID NO: 1468, SEQ ID
NO: 1469, SEQ ID NO: 1470, SEQ ID NO: 1471, SEQ ID NO: 1472, SEQ ID
NO: 1473, SEQ ID NO: 1474, SEQ ID NO: 1475, SEQ ID NO: 1476, SEQ ID
NO: 1477, SEQ ID NO: 1478, SEQ ID NO: 1479, SEQ ID NO: 1480, SEQ ID
NO: 1481, SEQ ID NO: 1482, SEQ ID NO: 1483, SEQ ID NO: 1484, SEQ ID
NO: 1485, SEQ ID NO: 1486, SEQ ID NO: 1487, SEQ ID NO: 1488, SEQ ID
NO: 1489, SEQ ID NO: 1490, SEQ ID NO: 1491, SEQ ID NO: 1492, SEQ ID
NO: 1493, SEQ ID NO: 1494, SEQ ID NO: 1495, SEQ ID NO: 1496, SEQ ID
NO: 1497, SEQ ID NO: 1498, SEQ ID NO: 1499, SEQ ID NO: 1500, SEQ ID
NO: 1501, SEQ ID NO: 1502, SEQ ID NO: 1503, SEQ ID NO: 1504, SEQ ID
NO: 1505, SEQ ID NO: 1506, SEQ ID NO: 1507, SEQ ID NO: 1508, SEQ ID
NO:1509, SEQ ID NO:1510, SEQ ID NO:1511, SEQ ID NO:1512, SEQ ID
NO:1513, SEQ ID NO:1514, SEQ ID NO:1515, SEQ ID NO:1516, SEQ ID
NO: 1517, SEQ ID NO:1518, and SEQ ID NO:1519;
or a complement of said sequence.

3. An isolated polynucleotide consisting essentially of a nucleotide sequence
selected from the group consisting of:

SEQ ID NO:l, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ
ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID

618

WO 98/45437

PCT/US98/06956

NO: 1 1, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ
ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO:20, SEQ
ID NO:21, SEQ ID NO;22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ
ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ
ID NO:31, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ
ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ
ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ
ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ
ID NO:5 1 , SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ
ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ
ID NO:61, SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ
ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ
ID NO:71, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ
ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ
ID NO:81, SEQ ID NO:82 t SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ
ID NO:86, SEQ ID NO:87 t SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ
ID NO:91 , SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ
ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO: 100,
SEQ ID NO: 101, SEQ ID NO: 102, SEQ ID NO: 103, SEQ ID NO: 104, SEQ ID
NO: 105, SEQ ID NO: 106, SEQ ID NO: 107, SEQ ID NO: 108, SEQ ID NO: 109,
SEQ ID NO: 110, SEQ ID NO: 111, SEQ ID NO: 112, SEQ ID NO: 113, SEQ ID
NO: 1 14, SEQ ID NO: 1 15, SEQ ID NO: 1 16, SEQ ID NO: 1 17, SEQ ID NO: 1 18,
SEQ ID NO: 119, SEQ ID NO: 120, SEQ ID NO: 121, SEQ ID NO: 122, SEQ ID
NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 127,
SEQ ID NO: 128, SEQ ID NO: 129, SEQ ID NO: 130, SEQ ID NO: 131, SEQ ID
NO: 132, SEQ ID NO: 133, SEQ ID NO: 134, SEQ ID NO: 135, SEQ ID NO: 136,
SEQ ID NO: 137, SEQ ID NO: 138, SEQ ID NO: 139, SEQ ID NO: 140, SEQ ID
NO: 141, SEQ ID NO: 142, SEQ ID NO: 143, SEQ ID NO: 144, SEQ ID NO: 145,
SEQ ID NO: 146, SEQ ID NO: 147, SEQ ID NO: 148, SEQ ID NO: 149, SEQ ID
NO: 150, SEQ ID NO: 151, SEQ ID NO: 152, SEQ ID NO: 153, SEQ ID NO: 154,
SEQ ID NO: 155, SEQ ID NO: 156, SEQ ID NO: 157, SEQ ID NO: 158, SEQ ID
NO: 159, SEQ ID NO: 160, SEQ ID NO: 161 , SEQ ID NO: 162, SEQ ID NO: 163,
SEQ ID NO: 164, SEQ ID NO: 165, SEQ ID NO: 166, SEQ ID NO: 167, SEQ ID
NO: 168, SEQ ID NO: 169, SEQ ID NO: 170, SEQ ID NO: 171, SEQ ID NO: 172,

619

WO 98/45437

PCT/US98/06956

SEQ ID NO: 173, SEQ ID NO: 174, SEQ ID NO: 175, SEQ ID NO: 176, SEQ ID
NO:177, SEQ ID NO: 178, SEQ ID NO: 179, SEQ ID NO: 180, SEQ ID NO: 181,
SEQ ID NO: 182, SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO: 185, SEQ ID
NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, SEQ ID NO: 189, SEQ ID NO: 190,
SEQ ID NO: 191, SEQ ID NO: 192, SEQ ID NO: 193, SEQ ID NO: 194, SEQ ID
NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199,
SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID
NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208,
SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:21 1, SEQ ID NO:212, SEQ ID
NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217,
SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID
NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226,
SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID
NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235,
SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238, SEQ ID NO:239, SEQ ID
NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244,
SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:247, SEQ ID NO:248, SEQ ID
NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253,
SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID
NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:261, SEQ ID NO:262,
SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID
NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271,
SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274 t SEQ ID NO:275, SEQ ID
NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280,
SEQ ID NO:281, SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID
NO:285, SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289,
SEQ ID NO:290, SEQ ID NO:291, SEQ ID NO:292, SEQ ID NO:293, SEQ ID
NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298,
SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO:301, SEQ ID NO:302, SEQ ID
NO:303, SEQ ID NO:304, SEQ ID NO:305, SEQ ID NO:306, SEQ ID NO:307,
SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:310, SEQ ID NO:311, SEQ ID
NO:312, SEQ ID NO:313, SEQ ID NO:314 f SEQ ID NO:315, SEQ ID NO:316,
SEQ ID NO:317, SEQ ID NO:318, SEQ ID NO:319, SEQ ID NO:320, SEQ ID
NO:321, SEQ ID NO:322, SEQ ID NO:323, SEQ ID NO:324, SEQ ID NO:325,

620

WO 98/45437

PCT/US98/06956

SEQ ID NO:326, SEQ ID NO:327, SEQ ID NO:328, SEQ ID NO:329, SEQ ID
NO:330, SEQ ID NO:331, SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334,
SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO;338, SEQ ID
NO:339, SEQ ID NO:340, SEQ ID NO:341 , SEQ ID NO:342, SEQ ID NO:343 >
SEQ ID NO:344, SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID
NO:348, SEQ ID NO:349,SEQ ID NO:350, SEQ ID NO:351, SEQ ID NO:352,
SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356 t SEQ ID
NO:357, SEQ ID NO:358, SEQ ID NO:359, SEQ ID NO:360, SEQ ID NO:361,
SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID
NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369, SEQ ID NO:370,
SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373, SEQ ID NO:374, SEQ ID
NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379,
SEQ ID NO:380, SEQ ID NO:381, SEQ ID NO:382, SEQ ID NO:383, SEQ ID
NO:384 r SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388>
SEQ ID NO:389, SEQ ID NOI390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID
NO:393, SEQ ID NO:394, SEQ ID NO:395, SEQ ID NO:396, SEQ ID NO:397,
SEQ ID NO:398, SEQ ID NO:399, SEQ ID NO:400, SEQ ID NO:401, SEQ ID
NO:402, SEQ ID NO:403, SEQ ID NO;404, SEQ ID NO:405, SEQ ID NO:406,
SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410, SEQ ID
NO:411, SEQ ID NO:412, SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415 t
SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418, SEQ ID NO:419, SEQ ID
NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424,
SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO:428 7 SEQ ID
NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433,
SEQ ID NO:434, SEQ ID NO:435, SEQ ID NO:436, SEQ ID NO:437, SEQ ID
NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441 t SEQ ID NO:442,
SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446, SEQ ID
NO:447, SEQ ID NO:448, SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451,
SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID
NO:456, SEQ ID NO:457, SEQ ID NO:458, SEQ ID NO:459, SEQ ID NO:460,
SEQ ID NO:461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO:464, SEQ ID
NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469,
SEQ ID NO:470, SEQ ID NO:471 f SEQ ID NO:472, SEQ ID NO:473, SEQ ID
NO:474, SEQ ID NO:475, SEQ ID NO:476, SEQ ID NO:477, SEQ ID NO:478,

621

WO 98/45437

PCT/US98/06956

SEQ ID NO:479, SEQ ID NO:480, SEQ ID NO:481, SEQ ID NO:482, SEQ ID
NO:483, SEQ ID NO:484, SEQ ID NO:485, SEQ ID NO:486. SEQ ID NO:487,
SEQ ID NO:488, SEQ ID NO:489, SEQ ID NO:490, SEQ ID NO:491, SEQ ID
NO:492, SEQ ID NO:493, SEQ ID NO:494, SEQ ID NO:495, SEQ ID NO:496,
SEQ ID NO:497, SEQ ID NO:498, SEQ ID NO:499, SEQ ID NO:500, SEQ ID
NO:501, SEQ ID NO:502, SEQ ID NO:503, SEQ ID NO:504, SEQ ID NO:505,
SEQ ID NO:506, SEQ ID NO:507, SEQ ID NO:508, SEQ ID NO:509, SEQ ID
NO:510, SEQ ID NO:511, SEQ ID N0:512, SEQ ID NO:5I3, SEQ ID NO:514,
SEQ ID NO:515 T SEQ ID NO:516, SEQ ID NO:517, SEQ ID NO:518, SEQ ID
NO:519, SEQ ID NO:520 T SEQ ID NO:521, SEQ ID NO:522, SEQ ID NO:523,
SEQ ID NO:524, SEQ ID NO:525, SEQ ID NO;526, SEQ ID NO:527, SEQ ID
NO:528, SEQ ID NO:529, SEQ ID NO:530, SEQ ID NO:53i, SEQ ID NO:532,
SEQ ID NO:533, SEQ ID NO:534, SEQ ID NO:535, SEQ ID NO:536, SEQ ID
NO:537, SEQ ID NO:538, SEQ ID NO:539, SEQ ID NO:540, SEQ ID NO:541,
SEQ ID NO:542, SEQ ID NO:543, SEQ ID NO:544, SEQ ID NO:545, SEQ ID
NO:546, SEQ ID NO:547, SEQ ID NO:548, SEQ ID NO:549, SEQ ID NO:550,
SEQ ID NO:551, SEQ ID NO:552 T SEQ ID NO:553, SEQ ID NO:554, SEQ ID
NO:555, SEQ ID NO:556, SEQ ID NO:557, SEQ ID NO:558, SEQ ID NO:559,
SEQ ID NO:560, SEQ ID NO:561, SEQ ID NO:562, SEQ ID NO:563, SEQ ID
NO:564, SEQ ID NO:565, SEQ ID NO:566, SEQ ID NO:567, SEQ ID NO:568,
SEQ ID NO:569, SEQ ID NO:570, SEQ ID NO:571, SEQ ID NO:572, SEQ ID
NO:573, SEQ ID NO:574, SEQ ID NO:575, SEQ ID NO:576, SEQ ID NO:577,
SEQ ID NO:578, SEQ ID NO:579, SEQ ID NO:580, SEQ ID NO:581, SEQ ID
NO:582, SEQ ID NO:583, SEQ ID NO:584, SEQ ID NO:585, SEQ ID NO:586,
SEQ ID NO:587, SEQ ID NO:588, SEQ ID NO:589, SEQ ID NO:590 t SEQ ID
NO:591, SEQ ID NO:592, SEQ ID NO:593, SEQ ID NO:594, SEQ ID NO:595,
SEQ ID NO:596, SEQ ID NO:597, SEQ ID NO:598, SEQ ID NO:599, SEQ ID
NO:600, SEQ ID NO:601, SEQ ID NO:602, SEQ ID NO:603, SEQ ID NO:604,
SEQ ID NO:605, SEQ ID NO:606, SEQ ID NO:607, SEQ ID NO:608, SEQ ID
NO:609, SEQ ID NO:610 7 SEQ ID NO:61 1, SEQ ID NO:612, SEQ ID NO:613,
SEQ ID NO:614, SEQ ID NO:615, SEQ ID NO:6i6, SEQ ID NO:617, SEQ ID
NO:618, SEQ ID NO:619, SEQ ID NO:620, SEQ ID NO:621, SEQ ID NO:622,
SEQ ID NO:623, SEQ ID NO:624, SEQ ID NO:625, SEQ ID NO:626, SEQ ID
NO:627, SEQ ID NO:628, SEQ ID NO:629, SEQ ID NO:630, SEQ ID NO:631,

622

WO 98/45437

PCT/US98/06956

SEQ ID NO:632, SEQ ID NO:633, SEQ ID NO:634, SEQ ID NO:635, SEQ ID
NO:636, SEQ ID NO:637, SEQ ID NO:638, SEQ ID NO:639, SEQ ID NO:640,
SEQ ID NO:641, SEQ ID NO:642, SEQ ID NO:643, SEQ ID NO: 644, SEQ ID
NO:645, SEQ ID NO:646, SEQ ID NO:647, SEQ ID NO:648, SEQ ID NO:649,
SEQ ID NO;650, SEQ ID NO:651, SEQ ID NO:652, SEQ ID NO:653, SEQ ID
NO:654, SEQ ID NO:655, SEQ ID NO:656 r SEQ ID NO:657, SEQ ID NO:658,
SEQ ID NO:659, SEQ ID NO:660, SEQ ID NO:661, SEQ ID NO:662, SEQ ID
NO:663, SEQ ID NO:664, SEQ ID NO:665, SEQ ID NO:666, SEQ ID NO:667,
SEQ ID NO:668, SEQ ID NO:669, SEQ ID NO:670, SEQ ID NO:671, SEQ ID
NO:672, SEQ ID NO:673, SEQ ID NO:674> SEQ ID NO:675, SEQ ID NO:676,
SEQ ID NO:677, SEQ ID NO:678, SEQ ID NO:679, SEQ ID NO:680, SEQ ID
NO:681, SEQ ID NO:682, SEQ ID NO:683, SEQ ID NO:684, SEQ ID NO:685,
SEQ ID NO:686, SEQ ID NO:687, SEQ ID NO:688, SEQ ID NO:689, SEQ ID
NO:690, SEQ ID NO:691, SEQ ID NO:692, SEQ ID NO:693, SEQ ID NO:694,
SEQ ID NO:695, SEQ ID NO:696, SEQ ID NO:697, SEQ ID NO:698, SEQ ID
NO:699, SEQ ID NO:700, SEQ ID NO:701, SEQ ID NO:702, SEQ ID NO:703,
SEQ ID NO:704, SEQ ID NO:705, SEQ ID NO:706, SEQ ID NO:707, SEQ ID
NO:708, SEQ ID NO:709, SEQ ID NO:710, SEQ ID NO:711, SEQ ID NO:712,
SEQ ID NO:713, SEQ ID NO:714, SEQ ID NO:715, SEQ ID NO:716, SEQ ID
NO:717, SEQ ID NO:718, SEQ ID NO:719, SEQ ID NO:720, SEQ ID NO:721,
SEQ ID NO:722 t SEQ ID NO:723, SEQ ID NO:724, SEQ ID NO:725, SEQ ID
NO:726, SEQ ID NO:727, SEQ ID NO:728, SEQ ID NO:729, SEQ ID NO:730,
SEQ ID NO:731, SEQ ID NO:732, SEQ ID NO:733, SEQ ID NO:734, SEQ ID
NO:735, SEQ ID NO:736, SEQ ID NO:737 t SEQ ID NO:738 t SEQ ID NO:739,
SEQ ID NO:740, SEQ ID NO:741, SEQ ID NO:742, SEQ ID NO:743, SEQ ID
NO:744, SEQ ID NO:745, SEQ ID NO:746, SEQ ID NO:747, SEQ ID NO:748,
SEQ ID NO:749, SEQ ID NO:750, SEQ ID NO:751, SEQ ID NO:752, SEQ ID
NO:753, SEQ ID NO:754, SEQ ID NO:755, SEQ ID NO:756, SEQ ID NO:757,
SEQ ID NO:758, SEQ ID NO:759, SEQ ID NO:760, SEQ ID NO:761, SEQ ID
NO:762, SEQ ID NO:763, SEQ ID NO:764, SEQ ID NO:765, SEQ ID NO:766,
SEQ ID NO:767, SEQ ID NO:768, SEQ ID NO:769, SEQ ID NO:770, SEQ ID
NO:771, SEQ ID NO:772, SEQ ID NO:773, SEQ ID NO:774, SEQ ID NO:775,
SEQ ID NO:776, SEQ ID NO:777, SEQ ID NO:778, SEQ ID NO:779, SEQ ID
NO:780, SEQ ID NO:781, SEQ ID NO:782, SEQ ID NO:783, SEQ ID NO:784,

623

WO 98/45437

PCT/US98/06956

SEQ ID NO:785, SEQ ID NO:786, SEQ ID NO:787, SEQ ID NO:788, SEQ ID
NO:789, SEQ ID NO:790, SEQ ID NO:791, SEQ ID NO:792, SEQ ID NO:793,
SEQ ID NO:794, SEQ ID NO:795, SEQ ID NO:796, SEQ ID NO:797, SEQ ID
NO:798, SEQ ID NO:799, SEQ ID NO:800. SEQ ID NO:801, SEQ ID NO:802,
SEQ ID NO:803, SEQ ID NO:804, SEQ ID NO:805, SEQ ID NO:806, SEQ ID
NO:807, SEQ ID NO:808,SEQ ID NO:809. SEQ ID NO:810, SEQ ID N0:8I1,
SEQ ID NO:812, SEQ ID NO:813, SEQ ID NO:814, SEQ ID NO:815, SEQ ID
NO:816, SEQ ID NO:817, SEQ ID NO:818, SEQ ID NO:819, SEQ ID NO:820,
SEQ ID NO:82U SEQ ID NO:822 ? SEQ ID NO:823 t SEQ ID NO:824, SEQ ID
NO:825 t SEQ ID NO:826, SEQ ID NO:827, SEQ ID NO:828, SEQ ID NO:829,
SEQ ID NO:830, SEQ ID NO:831, SEQ ID NO:832, SEQ ID NO:833, SEQ ID
NO:834, SEQ ID NO:835, SEQ ID NO:836 T SEQ ID NO:837, SEQ ID NO:838,
SEQ ID NO:839, SEQ ID NO:840, SEQ ID NO:841, SEQ ID NO:842, SEQ ID
NO:843, SEQ ID NO:844, SEQ ID NO:845, SEQ ID NO:846, SEQ ID NO:847,
SEQ ID NO:848 7 SEQ ID NO:849, SEQ ID NO:850, SEQ ID NO:851, SEQ ID
NO:852, SEQ ID NO:853, SEQ ID NO:854, SEQ ID NO:855, SEQ ID NO:856,
SEQ ID NO:857 T SEQ ID NO:858, SEQ ID NO:859 t SEQ ID NO:860, SEQ ID
NO:861, SEQ ID NO:862, SEQ ID NO:863 t SEQ ID NO:864 ? SEQ ID NO:865,
SEQ ID NO:866, SEQ ID NO:867, SEQ ID NO:868, SEQ ID NO:869, SEQ ID
NO:870, SEQ ID NO:871, SEQ ID NO:872, SEQ ID NO:873, SEQ ID NO:874,
SEQ ID NO:875, SEQ ID NO:876, SEQ ID NO:877, SEQ ID NO:878, SEQ ID
NO:879, SEQ ID NO:880, SEQ ID NO:88I, SEQ ID NO:882, SEQ ID NO:883,
SEQ ID NO:884, SEQ ID NO:885, SEQ ID NO:886, SEQ ID NO:887, SEQ ID
NO:888, SEQ ID NO:889, SEQ ID NO:890, SEQ ID NO:89l, SEQ ID NO:892,
SEQ ID NO:893, SEQ ID NO:894 > SEQ ID NO:895, SEQ ID NO:896, SEQ ID
NO:897, SEQ ID NO:898, SEQ ID NO:899, SEQ ID NO:900, SEQ ID NO:901,
SEQ ID NO:902, SEQ ID NO:903, SEQ ID NO:904, SEQ ID NO:905, SEQ ID
NO:906, SEQ ID NO:907 t SEQ ID NO:908, SEQ ID NO:909, SEQ ID NO:910,
SEQ ID NO:911, SEQ ID NO:9I2, SEQ ID NO:913, SEQ ID NO:914, SEQ ID
NO:915, SEQ ID NO:916, SEQ ID NO:917, SEQ ID NO:918, SEQ ID NO:919,
SEQ ID NO:920, SEQ ID NO:921, SEQ ID NO:922, SEQ ID NO:923, SEQ ID
NO:924, SEQ ID NO:925, SEQ ID NO:926, SEQ ID NO:927, SEQ ID NO:928,
SEQ ID NO:929, SEQ ID NO:930, SEQ ID NO:931, SEQ ID NO:932, SEQ ID
NO:933, SEQ ID NO:934, SEQ ID NO:935, SEQ ID NO:936, SEQ ID NO:937,

624

WO 98/45437

PCT/US98/06956

SEQ ID NO:938, SEQ ID NO:939, SEQ ID
NO:942, SEQ ID NO:943, SEQ ID NO:944,
SEQ ID NO:947, SEQ ID NO:948, SEQ ID
NO:951, SEQ ID NO:952, SEQ ID NO:953,
SEQ ID NO:956, SEQ ID NO:957, SEQ ID
NO:960, SEQ ID NO:961, SEQ ID NO:962,
SEQ ID NO:965, SEQ ID NO:966, SEQ ID
NO:969, SEQ ID NO:970, SEQ ID NO:971,
SEQ ID NO:974, SEQ ID NO:975, SEQ ID
NO:978, SEQ ID NO:979, SEQ ID NO:980,
SEQ ID NO:983, SEQ ID NO:984, SEQ ID
NO:987, SEQ ID NO:988, SEQ ID NO:989,
SEQ ID NO: 992, SEQ ID NO: 993, SEQ ID
NO:996, SEQ ID NO:997, SEQ ID NO:998, SEQ ID NO:999, SEQ ID NO: 1000,
SEQ ID NO: 1001, SEQ ID NO: 1002, SEQ ID NO: 1003, SEQ ID NO: 1004, SEQ
ID NO: 1005, SEQ ID NO: 1006, SEQ ID NO: 1007, SEQ ID NO: 1008, SEQ ID
NO: 1009, SEQ ID NO: 1010, SEQ ID NO: 1011, SEQ ID NO: 1012, SEQ ID
NO: 1013, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1016, SEQ ID
NO: 1017, SEQ ID NO: 1018, SEQ ID NO: 1019, SEQ ID NO: 1020, SEQ ID
NO: 1021, SEQ ID NO:1022, SEQ ID NO:1023, SEQ ID NO:1024, SEQ ID
NO: 1025, SEQ ID NO: 1026, SEQ ID NO: 1027, SEQ ID NO: 1028, SEQ ID
NO: 1029, SEQ ID NO: 1030, SEQ ID NO: 1031, SEQ ID NO: 1032, SEQ ID
NO: 1033, SEQ ID NO: 1034, SEQ ID NO: 1035, SEQ ID NO: 1036, SEQ ID
NO: 1037, SEQ ID NO: 1038, SEQ ID NO: 1039, SEQ ID NO: 1040, SEQ ID
NO: 1041, SEQ ID NO: 1042, SEQ ID NO: 1043, SEQ ID NO: 1044, SEQ ID
NO: 1045, SEQ ID NO: 1046, SEQ ID NO: 1047, SEQ ID NO: 1048, SEQ ID
NO: 1049, SEQ ID NO: 1050, SEQ ID NO: 1051, SEQ ID NO: 1052, SEQ ID
NO: 1053, SEQ ID NO: 1054, SEQ ID NO: 1055, SEQ ID NO: 1056, SEQ ID
NO: 1057, SEQ ID NO: 1058, SEQ ID NO: 1059, SEQ ID NO: 1060, SEQ ID
NO: 1061, SEQ ID NO.1062, SEQ ID NO:1063, SEQ ID NO:1064, SEQ ID
NO: 1065, SEQ ID NO: 1066, SEQ ID NO: 1067, SEQ ID NO: 1068, SEQ ID
NO: 1069, SEQ ID NO: 1070, SEQ ID NO: 1071, SEQ ID NO: 1072, SEQ ID
NO: 1073, SEQ ID NO: 1074, SEQ ID NO: 1075, SEQ ID NO: 1076, SEQ ID
NO: 1077, SEQ ID NO: 1078, SEQ ID NO: 1079, SEQ ID NO: 1080, SEQ ID

NO:940, SEQ ID NO:941, SEQ ID
SEQ ID NO:945, SEQ ID NO:946,
NO:949, SEQ ID NO:950, SEQ ID
SEQ ID NO:954, SEQ ID NO:955,
NO:958, SEQ ID NO:959, SEQ ID
SEQ ID NO:963, SEQ ID NO:964,
NO:967, SEQ ID NO:968, SEQ ID
SEQ ID NO:972, SEQ ID NO:973,
NO:976, SEQ ID NO:977, SEQ ID
SEQ ID NO:981, SEQ ID NO:982,
NO:985, SEQ ID NO:986, SEQ ID
SEQ ID NO:990, SEQ ID NO:991,
NO:994, SEQ ID NO:995, SEQ ID

625

WO 98/45437

PCT/US98/06956

NO: 1081, SEQ ID NO: 1082, SEQ ID
NO: 1085, SEQ ID NO: 1086, SEQ ID
NO: 1089, SEQ ID NO: 1090, SEQ ID
NO: 1093, SEQ ID NO: 1094, SEQ ID
NO: 1097, SEQ ID NO: 1098, SEQ ID
NO: 1101, SEQ ID NO: 1102, SEQ ID
NO: i 105, SEQ ID NO: 1106, SEQ ID
NO: 1109, SEQ ID NO: 11 10, SEQ ID
NO: 11 13, SEQ ID NO: 11 14, SEQ ID
NO: 11 17, SEQ ID NO: 11 18, SEQ ID
NO: 1121, SEQ ID NO: 1122, SEQ ID
NO: 1125, SEQ ID NO: 1 126, SEQ ID
NO: 1129, SEQ ID NO: 1130, SEQ ID
NO: 1133, SEQ ID NO: 1134, SEQ ID
NO: 1137, SEQ ID NO: 1138, SEQ ID
NO: 1141, SEQ ID NO: 1142, SEQ ID
NO: 1145, SEQ ID NO: 1146, SEQ ID
NO: 1149, SEQ ID NO: 1150, SEQ ID
NO: 1153, SEQ ID NO: 1154, SEQ ID
NO: 1157, SEQ ID NO: 1158, SEQ ID
NO: 1161, SEQ ID NO: 1162, SEQ ID
NO: 1165, SEQ ID NO: 1166, SEQ ID
NO: 1169, SEQ ID NO: 1170, SEQ ID
NO: 1173, SEQ ID NO: 1174, SEQ ID
NO: 1177, SEQ ID NO: 1178, SEQ ID
NO: 1181, SEQ ID NO: 1182, SEQ ID
NO:1185, SEQ ID NO:1186, SEQ ID
NO: 1189, SEQ ID NO: 1190, SEQ ID
NO: 1193, SEQ ID NO: 1194, SEQ ID
NO: 1197, SEQ ID NO: 1198, SEQ ID
NO: 1201, SEQ ID NO: 1202, SEQ ID
NO: 1205, SEQ ID NO: 1206, SEQ ID
NO: 1209, SEQ ID NO: 1210, SEQ ID
NO: 1213, SEQ ID NO: 1214, SEQ ID

NO: 1083, SEQ ID NO: 1084, SEQ ID
NO: 1087, SEQ ID NO: 1088, SEQ ID
NO: 1091, SEQ ID NO: 1092, SEQ ID
NO: 1095, SEQ ID NO: 1096, SEQ ID
NO:1099, SEQ ID NO:1100, SEQ ID
NO: 1103, SEQ ID NO: 1104, SEQ ID
NO: 1107, SEQ ID NO: 1108, SEQ ID
NO:llll, SEQ ID NO:1112, SEQ ID
NO: 11 15, SEQ ID NO: 11 16, SEQ ID
NO: 11 19, SEQ ID NO: 1120, SEQ ID
NO: 1123, SEQ ID NO: 1124, SEQ ID
NO: 1127, SEQ ID NO: 1128, SEQ ID
NO: 1131, SEQ ID NO: 1132, SEQ ID
NO: 1135, SEQ ID NO: 1136, SEQ ID
NO: 1139, SEQ ID NO: 1140, SEQ ID
NO: 1143, SEQ ID NO: 1144, SEQ ID
NO: 1147, SEQ ID NO: 1148, SEQ ID
NO: 1151, SEQ ID NO: 1152, SEQ ID
NO: 1155, SEQ ID NO: 1156, SEQ ID
NO: 1159, SEQ ID NO: 1160, SEQ ID
NO: 1163, SEQ ID NO: 1164, SEQ ID
NO: 1167, SEQ ID NO: 1168, SEQ ID
NO: 1171, SEQ ID NO: 1172, SEQ ID
NO: 1175, SEQ ID NO: 1176, SEQ ID
NO: 1179, SEQ ID NO: 1180, SEQ ID
NO:1183, SEQ ID NO:1184, SEQ ID
NO: 1187, SEQ ID NO: 1188, SEQ ID
NO:1191, SEQ ID NO:1192, SEQ ID
NO: 1195, SEQ ID NO: 1196, SEQ ID
NO: 1199, SEQ ID NO: 1200, SEQ ID
NO: 1203, SEQ ID NO: 1204, SEQ ID
NO:1207, SEQ ID NO:1208, SEQ ID
NO:1211, SEQ ID NO:1212, SEQ ID
NO: 1215, SEQ ID NO: 1216, SEQ ID

626

WO 98/45437

PCT/US98/06956

NO: 1217, SEQ ID NO: 1218, SEQ ID
NO: 1221, SEQ ID NO: 1222, SEQ ID
NO: 1225, SEQ ID NO: 1226, SEQ ID
NO: 1229, SEQ ID NO: 1230, SEQ ID
NO: 1233, SEQ ID NO: 1234, SEQ ID
NO: 1237, SEQ ID NO: 1238, SEQ ID
NO: 1241, SEQ ID NO:1242, SEQ ID
NO: 1245, SEQ ID NO: 1246, SEQ ID
NO: 1249, SEQ ID NO: 1250, SEQ ID
NO: 1253, SEQ ID NO: 1254, SEQ ID
NO: 1257, SEQ ID NO: 1258, SEQ ID
NO: 1261, SEQ ID NO: 1262, SEQ ID
NO:1265 r SEQ ID NO: 1266, SEQ ID
NO: 1269, SEQ ID NO: 1270, SEQ ID
NO: 1273, SEQ ID NO: 1274, SEQ ID
NO: 1277, SEQ ID NO: 1278, SEQ ID
NO: 1281, SEQ ID NO: 1282, SEQ ID
NO; 1285, SEQ ID NO: 1286, SEQ ID
NO: 1289, SEQ ID NO: 1290, SEQ ID
NO: 1293, SEQ ID NO: 1294, SEQ ID
NO: 1297, SEQ ID NO: 1298, SEQ ID
NO: 1301, SEQ ID NO: 1302, SEQ ID
NO: 1305, SEQ ID NO: 1306, SEQ ID
NO: 1309, SEQ ID NO: 13 10, SEQ ID
NO: 1313, SEQ ID NO: 13 14, SEQ ID
NO: 1317, SEQ ID NO: 13 18, SEQ ID
NO: 1321, SEQ ID NO: 1322, SEQ ID
NO: 1325, SEQ ID NO: 1326, SEQ ID
NO: 1329, SEQ ID NO: 1330, SEQ ID
NO: 1333, SEQ ID NO: 1334, SEQ ID
NO: 1337, SEQ ID NO: 1338, SEQ ID
NO: 1341, SEQ ID NO: 1342, SEQ ID
NO: 1345, SEQ ID NO: 1346, SEQ ID
NO: 1349, SEQ ID NO: 1350, SEQ ID

NO: 1219, SEQ ID NO: 1220, SEQ ID
NO: 1223, SEQ ID NO: 1224, SEQ ID
NO: 1227, SEQ ID NO: 1228, SEQ ID
NO: 1231, SEQ ID NO: 1232, SEQ ID
NO: 1235, SEQ ID NO: 1236, SEQ ID
NO: 1239. SEQ ID NO: 1240, SEQ ID
NO: 1243, SEQ ID NO: 1244, SEQ ID
NO: 1247, SEQ ID NO: 1248, SEQ ID
NO: 1251, SEQ ID NO: 1252, SEQ ID
NO: 1255, SEQ ID NO: 1256, SEQ ID
NO: 1259, SEQ ID NO: 1260, SEQ ID
NO: 1263, SEQ ID NO: 1264, SEQ ID
NO: 1267, SEQ ID NO: 1268, SEQ ID
NO: 1271, SEQ ID NO: 1272, SEQ ID
NO: 1275, SEQ ID NO: 1276, SEQ ID
NO: 1279, SEQ ID NO: 1280, SEQ ID
NO: 1283, SEQ ID NO: 1284, SEQ ID
NO: 1287, SEQ ID NO: 1288, SEQ ID
NO: 1291, SEQ ID NO: 1292, SEQ ID
NO: 1295, SEQ ID NO: 1296, SEQ ID
NO: 1299, SEQ ID NO: 1300, SEQ ID
NO: 1303, SEQ ID NO: 1304, SEQ ID
NO: 1307, SEQ ID NO: 1308, SEQ ID
NO: 1311, SEQ ID NO: 13 12, SEQ ID
NO: 1315, SEQ ID NO: 13 16, SEQ ID
NO: 1319, SEQ ID NO: 1320, SEQ ID
NO: 1323, SEQ ID NO: 1324, SEQ ID
NO: 1327, SEQ ID NO: 1328, SEQ ID
NO: 1331, SEQ ID NO: 1332, SEQ ID
NO: 1335, SEQ ID NO: 1336, SEQ ID
NO: 1339, SEQ ID NO: 1340, SEQ ID
NO: 1343, SEQ ID NO: 1344, SEQ ID
NO:1347, SEQ ID NO:1348, SEQ ID
NO: 1351, SEQ ID NO: 1352, SEQ ID

627

WO 98/45437

PCT/US98/06956

NO: 1353, SEQ ID NO: 1354, SEQ ID
NO: 1357, SEQ ID NO: 1358, SEQ ID
NO: 1361, SEQ ID NO: 1362, SEQ ID
NO: 1365, SEQ ID NO: 1366, SEQ ID
NO: 1369, SEQ ID NO: 1370, SEQ ID
NO: 1373, SEQ ID NO: 1374, SEQ ID
NO: 1377, SEQ ID NO: 1378, SEQ ID
NO: 1381, SEQ ID NO: 1382, SEQ ID
NO: 1385, SEQ ID NO: 1386, SEQ ID
NO: 1389, SEQ ID NO: 1390, SEQ ID
NO: 1393, SEQ ID NO: 1394, SEQ ID
NO: 1397, SEQ ID NO: 1398, SEQ ID
NO: 1401, SEQ ID NO: 1402, SEQ ID
NO: 1405, SEQ ID NO: 1406, SEQ ID
NO: 1409, SEQ ID NO: 1410, SEQ ID
NO:1413, SEQ ID NO:1414, SEQ ID
NO: 1417, SEQ ID NO:1418, SEQ ID
NO: 1421, SEQ ID NO: 1422, SEQ ID
NO: 1425, SEQ ID NO: 1426, SEQ ID
NO: 1429, SEQ ID NO: 1430, SEQ ID
NO: 1433, SEQ ID NO: 1434, SEQ ID
NO: 1437, SEQ ID NO: 1438, SEQ ID
NO: 1441, SEQ ID NO: 1442, SEQ ID
NO: 1445, SEQ ID NO: 1446, SEQ ID
NO: 1449, SEQ ID NO: 1450, SEQ ID
NO: 1453, SEQ ID NO: 1454, SEQ ID
NO: 1457, SEQ ID NO: 1458, SEQ ID
NO: 1461, SEQ ID NO: 1462, SEQ ID
NO: 1465, SEQ ID NO: 1466, SEQ ID
NO: 1469, SEQ ID NO: 1470, SEQ ID
NO: 1473, SEQ ID NO: 1474, SEQ ID
NO: 1477, SEQ ID NO: 1478, SEQ ID
NO: 1481, SEQ ID NO: 1482, SEQ ID
NO: 1485, SEQ ID NO: 1486, SEQ ID

628

NO: 1355, SEQ ID NO: 1356, SEQ ID
NO: 1359, SEQ ID NO: 1360, SEQ ID
NO: 1363, SEQ ID NO: 1364, SEQ ID
NO: 1367, SEQ ID NO: 1368, SEQ ID
NO: 1371, SEQ ID NO:1372, SEQ ID
NO: 1375, SEQ ID NO: 1376, SEQ ID
NO: 1379, SEQ ID NO: 1380, SEQ ID
NO: 1383, SEQ ID NO: 1384, SEQ ID
NO: 1387, SEQ ID NO: 1388, SEQ ID
NO: 1391, SEQ ID NO: 1392, SEQ ID
NO: 1395, SEQ ID NO: 1396, SEQ ID
NO: 1399, SEQ ID NO: 1400, SEQ ID
NO: 1403, SEQ ID NO: 1404, SEQ ID
NO: 1407, SEQ ID NO: 1408, SEQ ID
NO: 1411, SEQ ID NO: 1412, SEQ ID
NO: 1415, SEQ ID NO: 1416, SEQ ID
NO: 1419, SEQ ID NO: 1420, SEQ ID
NO: 1423, SEQ ID NO: 1424, SEQ ID
NO: 1427, SEQ ID NO: 1428, SEQ ID
NO: 1431, SEQ ID NO: 1432, SEQ ID
NO: 1435, SEQ ID NO: 1436, SEQ ID
NO: 1439, SEQ ID NO: 1440, SEQ ID
NO: 1443, SEQ ID NO: 1444, SEQ ID
NO: 1447, SEQ ID NO: 1448, SEQ ID
NO: 1451, SEQ ID NO: 1452, SEQ ID
NO:1455, SEQ ID NO:1456, SEQ ID
NO: 1459, SEQ ID NO: 1460, SEQ ID
NO: 1463, SEQ ID NO: 1464, SEQ ID
NO: 1467, SEQ ID NO: 1468, SEQ ID
NO: 1471, SEQ ID NO: 1472, SEQ ID
NO: 1475, SEQ ID NO: 1476, SEQ ID
NO: 1479, SEQ ID NO: 1480, SEQ ID
NO: 1483, SEQ ID NO: 1484, SEQ ID
NO: 1487, SEQ ID NO: 1488, SEQ ID

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NO: 1489, SEQ ID NO: 1490, SEQ ID NO: 1491, SEQ ID NO: 1492, SEQ ID
NO: 1493, SEQ ID NO: 1494, SEQ ID NO: 1495, SEQ ID NO: 1496, SEQ ID
NO: 1497, SEQ ID NO: 1498, SEQ ID NO: 1499, SEQ ID NO: 1500, SEQ ID
NO: 1501, SEQ ID NO: 1502, SEQ ID NO: 1503, SEQ ID NO: 1504, SEQ ID
NO: 1505, SEQ ID NO: 1506, SEQ ID NO: 1507, SEQ ID NO: 1508, SEQ ID
NO: 1509, SEQ ID NO: 15 10, SEQ ID NO: 15 11, SEQ ID NO: 1512, SEQ ID
NO:1513, SEQ ID NO:1514, SEQ ID NO:1515, SEQ ID NO:1516, SEQ ID
NO: 1517, SEQ ID NO: 1518, and SEQ ID NO: 1519;
or a complement of said sequence.

4. An isolated polynucleotide comprising a nucleotide sequence which
hybridizes to a sequence selected from the group consisting of:

SEQ ID NO: 1 , SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ
ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO: 10, SEQ ID
NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ
ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO:20, SEQ
ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, SEQ
ID NO:26, SEQ ID NO:27, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ
ID NO:3l, SEQ ID NO:32, SEQ ID NO:33, SEQ ID NO:34, SEQ ID NO:35, SEQ
ID NO:36, SEQ ID NO:37, SEQ ID NO:38, SEQ ID NO:39, SEQ ID NO:40, SEQ
ID NO:41, SEQ ID NO:42, SEQ ID NO:43, SEQ ID NO:44, SEQ ID NO:45, SEQ
ID NO:46, SEQ ID NO:47, SEQ ID NO:48, SEQ ID NO:49, SEQ ID NO:50, SEQ
ID NO:51 , SEQ ID NO:52, SEQ ID NO:53, SEQ ID NO:54, SEQ ID NO:55, SEQ
ID NO:56, SEQ ID NO:57, SEQ ID NO:58, SEQ ID NO:59, SEQ ID NO:60, SEQ
ID NO:61 , SEQ ID NO:62, SEQ ID NO:63, SEQ ID NO:64, SEQ ID NO:65, SEQ
ID NO:66, SEQ ID NO:67, SEQ ID NO:68, SEQ ID NO:69, SEQ ID NO:70, SEQ
ID NO:7i, SEQ ID NO:72, SEQ ID NO:73, SEQ ID NO:74, SEQ ID NO:75, SEQ
ID NO:76, SEQ ID NO:77, SEQ ID NO:78, SEQ ID NO:79, SEQ ID NO:80, SEQ
ID NO:81, SEQ ID NO:82, SEQ ID NO:83, SEQ ID NO:84, SEQ ID NO:85, SEQ
ID NO:86, SEQ ID NO:87, SEQ ID NO:88, SEQ ID NO:89, SEQ ID NO:90, SEQ
ID NO:91, SEQ ID NO:92, SEQ ID NO:93, SEQ ID NO:94, SEQ ID NO:95, SEQ
ID NO:96, SEQ ID NO:97, SEQ ID NO:98, SEQ ID NO:99, SEQ ID NO:100,
SEQ ID NO: 101, SEQ ID NO: 102, SEQ ID NO: 103, SEQ ID NO: 104, SEQ ID
NO: 105, SEQ ID NO: 106, SEQ ID NO: 107, SEQ ID NO: 108, SEQ ID NO: 109,

629

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SEQ ID NO: 110, SEQ ID NO: 111, SEQ ID NO: 112, SEQ ID NO: 1 13, SEQ ID
NO: 1 14, SEQ ID NO: 1 15, SEQ ID NO: 1 16, SEQ ID NO: 1 17, SEQ ID NO: 1 18,
SEQ ID NO: 119, SEQ ID NO: 120, SEQ ID NO: 121, SEQ ID NO: 122, SEQ ID
NO: 123, SEQ ID NO: 124, SEQ ID NO: 125, SEQ ID NO: 126, SEQ ID NO: 127,
SEQ ID NO: 128, SEQ ID NO: 129, SEQ ID NO: 130, SEQ ID NO: 131, SEQ ID
NO: 132, SEQ ID NO: 133, SEQ ID NO: 134, SEQ ID NO: 135, SEQ ID NO: 136,
SEQ ID NO: 137, SEQ ID NO: 138, SEQ ID NO: 139, SEQ ID NO: 140, SEQ ID
NO: 141, SEQ ID NO: 142, SEQ ID NO: 143, SEQ ID NO: 144, SEQ ID NO: 145,
SEQ ID NO: 146, SEQ ID NO: 147, SEQ ID NO: 148, SEQ ID NO: 149, SEQ ID
NO: 150, SEQ ID NO: 151, SEQ ID NO: 152, SEQ ID NO: 153, SEQ ID NO: 154,
SEQ ID NO: 155, SEQ ID NO: 156, SEQ ID NO: 157, SEQ ID NO: 158, SEQ ID
NO: 159, SEQ ID NO: 160, SEQ ID NO: 161, SEQ ID NO: 162, SEQ ID NO: 163,
SEQ ID NO: 164, SEQ ID NO: 165, SEQ ID NO: 166, SEQ ID NO: 167, SEQ ID
NO: 168, SEQ ID NO: 169, SEQ ID NO: 170, SEQ ID NO: 171, SEQ ID NO: 172,
SEQ ID NO: 173, SEQ ID NO: 174, SEQ ID NO: 175, SEQ ID NO: 176, SEQ ID
NO: 177, SEQ ID NO: 178, SEQ ID NO: 179, SEQ ID NO: 180, SEQ ID NO: 181,
SEQ ID NO: 182, SEQ ID NO: 183, SEQ ID NO: 184, SEQ ID NO: 185, SEQ ID
NO: 186, SEQ ID NO: 187, SEQ ID NO: 188, SEQ ID NO: 189, SEQ ID NO: 190,
SEQ ID NO:191, SEQ ID NO:192, SEQ ID NO:193, SEQ ID NO:194, SEQ ID
NO: 195, SEQ ID NO: 196, SEQ ID NO: 197, SEQ ID NO: 198, SEQ ID NO: 199,
SEQ ID NO:200, SEQ ID NO:201, SEQ ID NO:202, SEQ ID NO:203, SEQ ID
NO:204, SEQ ID NO:205, SEQ ID NO:206, SEQ ID NO:207, SEQ ID NO:208,
SEQ ID NO:209, SEQ ID NO:210, SEQ ID NO:211, SEQ ID NO:212, SEQ ID
NO:213, SEQ ID NO:214, SEQ ID NO:215, SEQ ID NO:216, SEQ ID NO:217,
SEQ ID NO:218, SEQ ID NO:219, SEQ ID NO:220, SEQ ID NO:221, SEQ ID
NO:222, SEQ ID NO:223, SEQ ID NO:224, SEQ ID NO:225, SEQ ID NO:226,
SEQ ID NO:227, SEQ ID NO:228, SEQ ID NO:229, SEQ ID NO:230, SEQ ID
NO:231, SEQ ID NO:232, SEQ ID NO:233, SEQ ID NO:234, SEQ ID NO:235,
SEQ ID NO:236, SEQ ID NO:237, SEQ ID NO:238, SEQ ID NO:239, SEQ ID
NO:240, SEQ ID NO:241, SEQ ID NO:242, SEQ ID NO:243, SEQ ID NO:244,
SEQ ID NO:245, SEQ ID NO:246, SEQ ID NO:247, SEQ ID NO:248, SEQ ID
NO:249, SEQ ID NO:250, SEQ ID NO:251, SEQ ID NO:252, SEQ ID NO:253,
SEQ ID NO:254, SEQ ID NO:255, SEQ ID NO:256, SEQ ID NO:257, SEQ ID
NO:258, SEQ ID NO:259, SEQ ID NO:260, SEQ ID NO:261, SEQ ID NO:262,

630

WO 98/45437

PCT/US98/06956

SEQ ID NO:263, SEQ ID NO:264, SEQ ID NO:265, SEQ ID NO:266, SEQ ID
NO:267, SEQ ID NO:268, SEQ ID NO:269, SEQ ID NO:270, SEQ ID NO:271,
SEQ ID NO:272, SEQ ID NO:273, SEQ ID NO:274, SEQ ID NO:275, SEQ ID
NO:276, SEQ ID NO:277, SEQ ID NO:278, SEQ ID NO:279, SEQ ID NO:280,
SEQ ID NO:28I f SEQ ID NO:282, SEQ ID NO:283, SEQ ID NO:284, SEQ ID
NO:285, SEQ ID NO:286, SEQ ID NO:287, SEQ ID NO:288, SEQ ID NO:289,
SEQ ID NO:290, SEQ ID NO:29l, SEQ ID NO:292, SEQ ID NO:293, SEQ ID
NO:294, SEQ ID NO:295, SEQ ID NO:296, SEQ ID NO:297, SEQ ID NO:298,
SEQ ID NO:299, SEQ ID NO:300, SEQ ID NO:301, SEQ ID NO;302, SEQ ID
NO:303, SEQ ID NO:304, SEQ ID NO.305, SEQ ID NO:306, SEQ ID NO:307,
SEQ ID NO:308, SEQ ID NO:309, SEQ ID NO:310, SEQ ID NO:311, SEQ ID
NO:312, SEQ ID NO:313, SEQ ID NO:314, SEQ ID NO:315, SEQ ID NO:316,
SEQ ID NO:317, SEQ ID NO:318, SEQ ID NO:319, SEQ ID NO:320, SEQ ID
NO:321, SEQ ID NO:322, SEQ ID NO:323, SEQ ID NO:324, SEQ ID NO:325,
SEQ ID NO:326, SEQ ID NO:327 r SEQ ID NO:328, SEQ ID NO:329, SEQ ID
NO:330, SEQ ID NO:331, SEQ ID NO:332, SEQ ID NO:333, SEQ ID NO:334,
SEQ ID NO:335, SEQ ID NO:336, SEQ ID NO:337, SEQ ID NO:338, SEQ ID
NO:339, SEQ ID NO:340, SEQ ID NO:341, SEQ ID NO:342, SEQ ID NO:343,
SEQ ID NO:344 t SEQ ID NO:345, SEQ ID NO:346, SEQ ID NO:347, SEQ ID
NO:348, SEQ ID NO:349, SEQ ID NO:350, SEQ ID NO:351 ? SEQ ID NO:352,
SEQ ID NO:353, SEQ ID NO:354, SEQ ID NO:355, SEQ ID NO:356, SEQ ID
NO:357, SEQ ID NO:358, SEQ ID NO:359 t SEQ ID NO.360, SEQ ID NO:361,
SEQ ID NO:362, SEQ ID NO:363, SEQ ID NO:364, SEQ ID NO:365, SEQ ID
NO:366, SEQ ID NO:367, SEQ ID NO:368, SEQ ID NO:369, SEQ ID NO:370,
SEQ ID NO:371, SEQ ID NO:372, SEQ ID NO:373 t SEQ ID NO:374, SEQ ID
NO:375, SEQ ID NO:376, SEQ ID NO:377, SEQ ID NO:378, SEQ ID NO:379,
SEQ ID NO:380, SEQ ID NO:381, SEQ ID NO:382, SEQ ID NO:383, SEQ ID
NO:384, SEQ ID NO:385, SEQ ID NO:386, SEQ ID NO:387, SEQ ID NO:388,
SEQ ID NO:389, SEQ ID NO:390, SEQ ID NO:391, SEQ ID NO:392, SEQ ID
NO:393, SEQ ID NO:394, SEQ ID NO:395, SEQ ID NO:396, SEQ ID NO:397,
SEQ ID NO:398, SEQ ID NO:399, SEQ ID NO:400, SEQ ID NO:401, SEQ ID
NO:402, SEQ ID NO:403, SEQ ID NO:404, SEQ ID NO:405, SEQ ID NO:406,
SEQ ID NO:407, SEQ ID NO:408, SEQ ID NO:409, SEQ ID NO:410, SEQ ID
NO:411, SEQ ID NO:412, SEQ ID NO:413, SEQ ID NO:414, SEQ ID NO:415,

631

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SEQ ID NO:416, SEQ ID NO:417, SEQ ID NO:418, SEQ ID NO:4I9, SEQ ID
NO:420, SEQ ID NO:421, SEQ ID NO:422, SEQ ID NO:423, SEQ ID NO:424,
SEQ ID NO:425, SEQ ID NO:426, SEQ ID NO:427, SEQ ID NO;428, SEQ ID
NO:429, SEQ ID NO:430, SEQ ID NO:431, SEQ ID NO:432, SEQ ID NO:433,
SEQ ID NO:434 T SEQ ID NO:435; SEQ ID NO:436, SEQ ID NO:437, SEQ ID
NO:438, SEQ ID NO:439, SEQ ID NO:440, SEQ ID NO:441, SEQ ID NO:442,
SEQ ID NO:443, SEQ ID NO:444, SEQ ID NO:445, SEQ ID NO:446, SEQ ID
NO:447, SEQ ID NO:448, SEQ ID NO:449, SEQ ID NO:450, SEQ ID NO:451,
SEQ ID NO:452, SEQ ID NO:453, SEQ ID NO:454, SEQ ID NO:455, SEQ ID
NO:456, SEQ ID NO:457 t SEQ ID NO:458, SEQ ID NO:459, SEQ ID NO:460,
SEQ ID NO;461, SEQ ID NO:462, SEQ ID NO:463, SEQ ID NO:464, SEQ ID
NO:465, SEQ ID NO:466, SEQ ID NO:467, SEQ ID NO:468, SEQ ID NO:469,
SEQ ID NO:470, SEQ ID NO:471, SEQ ID NO:472, SEQ ID NO:473, SEQ ID
NO:474, SEQ ID NO:475 t SEQ ID NO:476, SEQ ID NO:477, SEQ ID NO:478,
SEQ ID NO:479, SEQ ID NO:480, SEQ ID NO:481, SEQ ID NO:482, SEQ ID
NO:483, SEQ ID NO:484, SEQ ID NO:485, SEQ ID NO:486, SEQ ID NO:487,
SEQ ID NO:488, SEQ ID NO:489, SEQ ID NO:490, SEQ ID NO:491, SEQ ID
NO:492, SEQ ID NO:493, SEQ ID NO:494, SEQ ID NO:495, SEQ ID NO:496,
SEQ ID NO:497, SEQ ID NO:498, SEQ ID NO:499, SEQ ID NO:500, SEQ ID
NO:501, SEQ ID NO:502, SEQ ID NO:503, SEQ ID NO:504 T SEQ ID NO:505,
SEQ ID NO:506, SEQ ID NO:507 T SEQ ID NO:508, SEQ ID NO:509, SEQ ID
NO:510, SEQ ID NO:511, SEQ ID NO:512, SEQ ID NO:513, SEQ ID NO:514,
SEQ ID NO:515, SEQ ID NO:516, SEQ ID NO:517, SEQ ID NO:518, SEQ ID
NO:519, SEQ ID NO:520, SEQ ID NO:521, SEQ ID NO:522, SEQ ID NO:523,
SEQ ID NO:524, SEQ ID NO:525, SEQ ID NO:526, SEQ ID NO:527, SEQ ID
NO:528 t SEQ ID NO:529, SEQ ID NO:530, SEQ ID NO:531, SEQ ID NO:532,
SEQ ID NO:533, SEQ ID NO:534, SEQ ID NO:535, SEQ ID NO:536, SEQ ID
NO:537, SEQ ID NO:538, SEQ ID NO:539, SEQ ID NO:540, SEQ ID NO:541,
SEQ ID NO:542, SEQ ID NO:543, SEQ ID NO:544, SEQ ID NO:545, SEQ ID
NO:546, SEQ ID NO:547, SEQ ID NO:548, SEQ ID NO:549, SEQ ID NO:550,
SEQ ID NO:551, SEQ ID NO:552, SEQ ID NO:553, SEQ ID NO:554, SEQ ID
NO:555, SEQ ID NO:556, SEQ ID NO:557, SEQ ID NO:558, SEQ ID NO:559,
SEQ ID NO:560, SEQ ID NO:561, SEQ ID NO:562> SEQ ID NO:563, SEQ ID
NO:564, SEQ ID NO:565, SEQ ID NO:566, SEQ ID NO:567, SEQ ID NO:568,

632

WO 98/45437

PCT/US98/06956

SEQ ID NO:569, SEQ ID NO:570, SEQ ID NO:571, SEQ ID NO:572, SEQ ID
NO:573, SEQ ID NO:574, SEQ ID NO:575, SEQ ID NO:576, SEQ ID NO:577,
SEQ ID NO:578, SEQ ID NO:579, SEQ ID NO:580, SEQ ID NO:581, SEQ ID
NO:582, SEQ ID NO:583, SEQ ID NO:584, SEQ ID NO:585, SEQ ID NO:586,
SEQ ID NO:587, SEQ ID NO:588, SEQ ID NO:589, SEQ ID NO:590, SEQ ID
NO:591, SEQ ID NO:592, SEQ ID NO:593, SEQ ID NO:594, SEQ ID NO:595 y
SEQ ID NO:596, SEQ ID NO:597, SEQ ID NO:598, SEQ ID NO:599, SEQ ID
NO:600, SEQ ID NO:601, SEQ ID NO:602, SEQ ID NO:603, SEQ ID NO:604,
SEQ ID NO:605, SEQ ID NO:606, SEQ ID NO:607, SEQ ID NO:608, SEQ ID
NO:609, SEQ ID NO:6iO, SEQ ID NO:6Il, SEQ ID NO:612, SEQ ID NO:613,
SEQ ID NO:614, SEQ ID NO:615, SEQ ID NO:616, SEQ ID NO:617, SEQ ID
NO:618, SEQ ID NO:619, SEQ ID NO:620, SEQ ID NO:621, SEQ ID NO:622,
SEQ ID NO:623, SEQ ID NO:624, SEQ ID NO:625, SEQ ID NO:626, SEQ ID
NO:627, SEQ ID NO:628, SEQ ID NO:629, SEQ ID NO:630, SEQ ID NO:631,
SEQ ID NO:632, SEQ ID NO:633, SEQ ID NO:634, SEQ ID NO:635, SEQ ID
NO:636, SEQ ID NO:637, SEQ ID NO:638, SEQ ID NO:639, SEQ ID NO:640,
SEQ ID NO:641, SEQ ID NO:642, SEQ ID NO:643, SEQ ID NO:644, SEQ ID
NO:645, SEQ ID NO:646, SEQ ID NO:647, SEQ ID NO:648, SEQ ID NO:649,
SEQ ID NO:650 T SEQ ID NO:651, SEQ ID NO:652, SEQ ID NO:653, SEQ ID
NO:654, SEQ ID NO:655, SEQ ID NO:656, SEQ ID NO:657, SEQ ID NO:658,
SEQ ID NO:659, SEQ ID NO:660, SEQ ID NO:661, SEQ ID NO:662 > SEQ ID
NO:663, SEQ ID NO:664, SEQ ID NO:665, SEQ ID NO:666, SEQ ID NO:667 T
SEQ ID NO:668, SEQ ID NO:669, SEQ ID NO:670, SEQ ID NO:671, SEQ ID
NO:672, SEQ ID NO.673, SEQ ID NO:674, SEQ ID NO:675, SEQ ID NO:676,
SEQ ID NO:677, SEQ ID NO:678, SEQ ID NO:679, SEQ ID NO:680, SEQ ID
NO:681 T SEQ ID NO:682, SEQ ID NO:683, SEQ ID NO:684 t SEQ ID NO:685 T
SEQ ID NO:686, SEQ ID NO:687, SEQ ID NO:688, SEQ ID NO:689, SEQ ID
NO:690, SEQ ID NO:691, SEQ ID NO:692, SEQ ID NO:693, SEQ ID NO:694,
SEQ ID NO:695, SEQ ID NO:696, SEQ ID NO:697, SEQ ID NO:698, SEQ ID
NO:699, SEQ ID NO:700, SEQ ID NO:701, SEQ ID NO:702, SEQ ID NO:703,
SEQ ID NO:704, SEQ ID NO:705, SEQ ID NO:706, SEQ ID NO:707, SEQ ID
NO:708, SEQ ID NO:709, SEQ ID NO:710, SEQ ID NO:711, SEQ ID NO:712,
SEQ ID NO:713, SEQ ID NO:714, SEQ ID NO:715, SEQ ID NO:716, SEQ ID
NO:717, SEQ ID NO:718, SEQ ID NO:719, SEQ ID NO:720, SEQ ID NO:721,

633

WO 98/45437

PCT/US98/06956

SEQ ID NO:722 T SEQ ID NO:723, SEQ ID NO:724, SEQ ID NO:725, SEQ ID
NO:726, SEQ ID NO:727, SEQ ID NO:728, SEQ ID NO:729, SEQ ID NO:730,
SEQ ID NO:73I, SEQ ID NO:732 t SEQ ID NO:733, SEQ ID NO: 734, SEQ ID
NO:735 T SEQ ID NO:736, SEQ ID NO:737, SEQ ID NO:738, SEQ ID NO:739,
SEQ ID NO:740, SEQ ID NO:741, SEQ ID NO:742, SEQ ID NO:743, SEQ ID
NO:744, SEQ ID NO:745, SEQ ID NO:746, SEQ ID NO;747, SEQ ID NO:748,
SEQ ID NO:749, SEQ ID NO:750, SEQ ID NO:751, SEQ ID NO:752, SEQ ID
NO:753, SEQ ID NO:754, SEQ ID NO:755, SEQ ID NO:756, SEQ ID NO:757,
SEQ ID NO:758, SEQ ID NO:759, SEQ ID NO:760, SEQ ID NO:761, SEQ ID
NO:762, SEQ ID NO:763, SEQ ID NO:764, SEQ ID NO:765, SEQ ID NO:766,
SEQ ID NO:767, SEQ ID NO:768, SEQ ID NO:769, SEQ ID NO:770, SEQ ID
NO:771, SEQ ID NO:772, SEQ ID NO:773, SEQ ID NO:774, SEQ ID NO:775,
SEQ ID NO:776, SEQ ID NO:777, SEQ ID NO:778, SEQ ID NO:779, SEQ ID
NO:780, SEQ ID NO:781, SEQ ID NO:782, SEQ ID NO:783, SEQ ID NO:784,
SEQ ID NO:785, SEQ ID NO:786, SEQ ID NO:787, SEQ ID NO:788, SEQ ID
NO:789, SEQ ID NO:790, SEQ ID NO:791, SEQ ID NO:792, SEQ ID NO:793,
SEQ ID NO:794 T SEQ ID NO:795, SEQ ID NO:796, SEQ ID NO:797, SEQ ID
NO:798, SEQ ID NO:799, SEQ ID NO:800, SEQ ID NO:801, SEQ ID NO:802,
SEQ ID NO:803, SEQ ID NO:804, SEQ ID NO:805, SEQ ID NO:806, SEQ ID
NO:807, SEQ ID NO:808, SEQ ID NO:809, SEQ ID NO:810, SEQ ID NO:811,
SEQ ID NO:8I2, SEQ ID NO:813, SEQ ID NO:814, SEQ ID NO:815, SEQ ID
NO:816, SEQ ID NO:817, SEQ ID NO:818, SEQ ID NO:819, SEQ ID NO:820,
SEQ ID NO:821, SEQ ID NO;822, SEQ ID NO:823, SEQ ID NO:824, SEQ ID
NO:825, SEQ ID NO:826, SEQ ID NO:827, SEQ ID NO:828, SEQ ID NO:829,
SEQ ID NO:830, SEQ ID NO:831, SEQ ID NO:832, SEQ ID NO:833, SEQ ID
NO:834, SEQ ID NO:835, SEQ ID NO:836, SEQ ID NO:837, SEQ ID NO:838,
SEQ ID NO:839, SEQ ID NO:840, SEQ ID NO:841, SEQ ID NO:842, SEQ ID
NO:843, SEQ ID NO:844, SEQ ID NO:845, SEQ ID NO:846, SEQ ID NO:847,
SEQ ID NO:848, SEQ ID NO:849, SEQ ID NO:850, SEQ ID NO:851, SEQ ID
NO:852, SEQ ID NO:853, SEQ ID NO:854, SEQ ID NO:855, SEQ ID NO:856,
SEQ ID NO:857, SEQ ID NO:858, SEQ ID NO:859, SEQ ID NO:860, SEQ ID
NO: 861, SEQ ID NO:862, SEQ ID NO:863 7 SEQ ID NO:864, SEQ ID NO:865,
SEQ ID NO:866, SEQ ID NO:867, SEQ ID NO:868, SEQ ID NO:869, SEQ ID
NO:870, SEQ ID NO:871, SEQ ID NO:872, SEQ ID NO:873, SEQ ID NO:874,

634

WO 98/45437

PCT/US98/06956

SEQ ID NO:875, SEQ ID NO:876, SEQ ID NO:877, SEQ ID NO:878, SEQ ID
NO:879, SEQ ID NO:880, SEQ ID NO:881, SEQ ID NO:882, SEQ ID NO:883,
SEQ ID NO:884, SEQ ID NO:885, SEQ ID NO:886, SEQ ID NO: 887, SEQ ID
NO:888, SEQ ID NO:889, SEQ ID NO;890, SEQ ID NO:891, SEQ ID NO:892,
SEQ ID NO:893, SEQ ID NO:894, SEQ ID NO:895, SEQ ID NO:896, SEQ ID
NO:897, SEQ ID NO:898, SEQ ID NO:899, SEQ ID NO:900, SEQ ID NO:901,
SEQ ID NO:902, SEQ ID NO:903, SEQ ID NO:904, SEQ ID NO:905, SEQ ID
NO:906, SEQ ID NO:907, SEQ ID NO:908 t SEQ ID NO:909, SEQ ID NO:910,
SEQ ID NO:911, SEQ ID NO:912, SEQ ID NO:913, SEQ ID NO:914, SEQ ID
NO:915, SEQ ID NO:916, SEQ ID NO:917, SEQ ID NO:918, SEQ ID NO:919,
SEQ ID NO:920, SEQ ID NO:921, SEQ ID NO:922, SEQ ID NO:923, SEQ ID
NO:924, SEQ ID NO:925, SEQ ID NO:926, SEQ ID NO:927, SEQ ID NO:928,
SEQ ID NO:929, SEQ ID NO:930, SEQ ID NO:931, SEQ ID NO:932, SEQ ID
NO:933, SEQ ID NO:934, SEQ ID NO:935, SEQ ID NO:936, SEQ ID NO:937,
SEQ ID NO:938, SEQ ID NO:939, SEQ ID NO:940, SEQ ID NO:941, SEQ ID
NO:942, SEQ ID NO:943, SEQ ID NO:944, SEQ ID NO:945, SEQ ID NO:946,
SEQ ID NO:947, SEQ ID NO:948, SEQ ID NO:949, SEQ ID NO:950, SEQ ID
NO:951, SEQ ID NO:952, SEQ ID NO:953, SEQ ID NO:954, SEQ ID NO:955,
SEQ ID NO:956, SEQ ID NO:957, SEQ ID NO:958, SEQ ID NO:959, SEQ ID
NO:960, SEQ ID NO:961, SEQ ID NO:962, SEQ ID NO:963, SEQ ID NO:964,
SEQ ID NO:965, SEQ ID NO:966, SEQ ID NO:967, SEQ ID NO:968, SEQ ID
NO:969, SEQ ID NO:970, SEQ ID NO:971, SEQ ID NO:972, SEQ ID NO:973,
SEQ ID NO:974, SEQ ID NO:975, SEQ ID NO:976, SEQ ID NO:977, SEQ ID
NO:978, SEQ ID NO:979, SEQ ID NO:980, SEQ ID NO:981, SEQ ID NO:982,
SEQ ID NO:983, SEQ ID NO:984, SEQ ID NO:985, SEQ ID NO:986, SEQ ID
NO:987, SEQ ID NO:988, SEQ ID NO:989, SEQ ID NO:990, SEQ ID NO:991,
SEQ ID NO:992, SEQ ID NO:993, SEQ ID NO:994, SEQ ID NO;995, SEQ ID
NO:996, SEQ ID NO:997, SEQ ID NO:998, SEQ ID NO:999, SEQ ID NO: 1000,
SEQ ID NO: 1001, SEQ ID NO: 1002, SEQ ID NO: 1003, SEQ ID NO: 1004, SEQ
ID NO: 1005, SEQ ID NO: 1006, SEQ ID NO: 1007, SEQ ID NO: 1008, SEQ ID
NO: 1009, SEQ ID NO: 1010, SEQ ID NO: 1011, SEQ ID NO: 1012, SEQ ID
NO: 1013, SEQ ID NO: 1014, SEQ ID NO: 1015, SEQ ID NO: 1016, SEQ ID
NO: 1017, SEQ ID NO: 1018, SEQ ID NO: 1019, SEQ ID NO: 1020, SEQ ID
NO: 1021, SEQ ID NO: 1022, SEQ ID NO: 1023, SEQ ID NO: 1024, SEQ ID

635

WO 98/45437 PCT/US98/06956

NO: 1025, SEQ ID NO: 1026, SEQ ID
NO: 1029, SEQ ID NO: 1030. SEQ ID
NO: 1033, SEQ ID NO: 1034, SEQ ID
NO: 1037, SEQ ID NO: 1038, SEQ ID
NO: 1041, SEQ ID NO: 1042, SEQ ID
NO: 1045, SEQ ID NO: 1046, SEQ ID
NO: 1049, SEQ ID NO: 1050, SEQ ID
NO: 1053, SEQ ID NO: 1054, SEQ ID
NO: 1057, SEQ ID NO: 1058, SEQ ID
NO: 1061, SEQ ID NO: 1062, SEQ ID
NO: 1065, SEQ ID NO: 1066, SEQ ID
NO: 1069, SEQ ID NO: 1070, SEQ ID
NO: 1073, SEQ ID NO: 1074, SEQ ID
NO: 1077, SEQ ID NO: 1078, SEQ ID
NO: 1081, SEQ ID NO: 1082, SEQ ID
NO: 1085, SEQ ID NO: 1086, SEQ ID
NO: 1089, SEQ ID NO: 1090, SEQ ID
NO: 1093, SEQ ID NO: 1094, SEQ ID
NO: 1097, SEQ ID NO: 1098, SEQ ID
NO: 1101, SEQ ID NO: 1102, SEQ ID
NO:1105, SEQ ID NO:1106, SEQ ID
NO: 1109, SEQ ID NO:1I10, SEQ ID
NO:1113, SEQ ID NO: 11 14, SEQ ID
NO: 11 17, SEQ ID NO: 11 18, SEQ ID
NO: 1121, SEQ ID NO: 1122, SEQ ID
NO: 1125, SEQ ID NO: 1126, SEQ ID
NO: 1129, SEQ ID NO: 1130, SEQ ID
NO: 1133, SEQ ID NO: 1134, SEQ ID
NO: 11 37, SEQ ID NO: 1138, SEQ ID
NO: 1141, SEQ ID NO: 1142, SEQ ID
NO: 1145, SEQ ID NO: 1146, SEQ ID
NO: 1149, SEQ ID NO: 1150, SEQ ID
NO: 1153, SEQ ID NO: 1154, SEQ ID
NO: 1157, SEQ ID NO: 1158, SEQ ID

NO: 1027, SEQ ID NO: 1028, SEQ ID
NO: 1031, SEQ ID NO: 1032, SEQ ID
NO: 1035, SEQ ID NO: 1036, SEQ ID
NO: 1039, SEQ ID NO: 1040, SEQ ID
NO: 1043, SEQ ID NO: 1044, SEQ ID
NO: 1047, SEQ ID NO: 1048, SEQ ID
NO: 1051, SEQ ID NO: 1052, SEQ ID
NO: 1055, SEQ ID NO: 1056, SEQ ID
NO: 1059, SEQ ID NO: 1060, SEQ ID
NO: 1063, SEQ ID NO: 1064, SEQ ID
NO:1067, SEQ ID NO:1068, SEQ ID
NO: 1071, SEQ ID NO: 1072, SEQ ID
NO: 1075, SEQ ID NO: 1076, SEQ ID
NO: 1079, SEQ ID NO: 1080, SEQ ID
NO: 1083, SEQ ID NO: 1084, SEQ ID
NO: 1087, SEQ ID NO: 1088, SEQ ID
NO: 1091, SEQ ID NO: 1092, SEQ ID
NO: 1095, SEQ ID NO: 1096, SEQ ID
NO: 1099, SEQ ID NO: 1100, SEQ ID
NO: 1103, SEQ ID NO: 1104, SEQ ID
NO: 1107, SEQ ID NO: 1108, SEQ ID
NO:llll, SEQ ID NO:1112, SEQ ID
NO: 11 15, SEQ ID NO: 11 16, SEQ ID
NO: 11 19, SEQ ID NO: 1120, SEQ ID
NO: 1123, SEQ ID NO: 1124, SEQ ID
NO: 1127, SEQ ID NO: 1128, SEQ ID
NO:113U SEQ ID NO: 1132, SEQ ID
NO: 1135, SEQ ID NO: 1136, SEQ ID
NO: 1139, SEQ ID NO: 1140, SEQ ID
NO: 1143, SEQ ID NO: 1144, SEQ ID
NO: 1147, SEQ ID NO: 1148, SEQ ID
NO:1151, SEQ ID NO:1152, SEQ ID
NO: 1155, SEQ ID NO: 1156, SEQ ID
NO: 1159, SEQ ID NO: 1160, SEQ ID

636

WO 98/45437

PCT/US98/06956

NO:1161, SEQ ID NO:1162, SEQ ID
NO: 1165, SEQ ID NO: 11 66, SEQ ID
NO: 1169, SEQ ID NO: 1170, SEQ ID
NO: 1173, SEQ ID NO: 1174, SEQ ID
NO: 1177, SEQ ID NO: 1178, SEQ ID
NO:1181, SEQ ID NO:1182, SEQ ID
NO: 1185, SEQ ID NO:1186, SEQ ID
NO: 1189, SEQ ID NO: 1190, SEQ ID
NO: 1193, SEQ ID NO: 1194, SEQ ID
NO: 1197, SEQ ID NO: 1198, SEQ ID
NO: 1201, SEQ ID NO: 1202, SEQ ID
NO: 1205, SEQ ID NO: 1206, SEQ ID
NO: 1209, SEQ ID NO: 1210, SEQ ID
NO: 1213, SEQ ID NO: 1214, SEQ ID
NO: 1217, SEQ ID NO: 1218, SEQ ID
NO: 1221, SEQ ID NO:1222, SEQ ID
NO: 1225, SEQ ID NO: 1226, SEQ ID
NO: 1229, SEQ ID NO: 1230, SEQ ID
NO: 1233, SEQ ID NO: 1234, SEQ ID
NO: 1237, SEQ ID NO: 1238, SEQ ID
NO: 1241, SEQ ID NO: 1242, SEQ ID
NO: 1245, SEQ ID NO: 1246, SEQ ID
NO: 1249, SEQ ID NO: 1250, SEQ ID
NO: 1253, SEQ ID NO: 1254, SEQ ID
NO: 1257, SEQ ID NO: 1258, SEQ ID
NO: 1261, SEQ ID NO: 1262, SEQ ID
NO: 1265, SEQ ID NO: 1266, SEQ ID
NO: 1269, SEQ ID NO: 1270, SEQ ID
NO: 1273, SEQ ID NO: 1274, SEQ ID
NO: 1277, SEQ ID NO: 1278, SEQ ID
NO: 1281, SEQ ID NO: 1282, SEQ ID
NO: 1285, SEQ ID NO: 1286, SEQ ID
NO: 1289, SEQ ID NO: 1290, SEQ ID
NO: 1293, SEQ ID NO: 1294, SEQ ID

NO: 1163, SEQ ID NO: 1164, SEQ ID
NO: 1167, SEQ ID NO: 1168, SEQ ID
NO: 1 171, SEQ ID NO: 1 172, SEQ ID
NO: 1175, SEQ ID NO: 1176, SEQ ID
NO: 1179, SEQ ID NO: 1180, SEQ ID
NO: 1183, SEQ ID NO: 1 184, SEQ ID
NO: 1187, SEQ ID NO: 1188, SEQ ID
NO: 1191, SEQ ID NO: 1192, SEQ ID
NO: 1195, SEQ ID NO: 1196, SEQ ID
NO: 1199, SEQ ID NO: 1200, SEQ ID
NO: 1203, SEQ ID NO: 1204, SEQ ID
NO: 1207, SEQ ID NO: 1208, SEQ ID
NO: 1211, SEQ ID NO:1212, SEQ ID
NO:1215, SEQ ID NO:1216, SEQ ID
NO: 1219, SEQ ID NO: 1220, SEQ ID
NO: 1223, SEQ ID NO: 1224, SEQ ID
NO: 1227, SEQ ID NO: 1228, SEQ ID
NO: 1231, SEQ ID NO:1232, SEQ ID
NO: 1235, SEQ ID NO: 1236, SEQ ID
NO: 1239, SEQ ID NO: 1240, SEQ ID
NO: 1243, SEQ ID NO: 1244, SEQ ID
NO: 1247, SEQ ID NO: 1248, SEQ ID
NO:1251, SEQ ID NO:1252, SEQ ID
NO: 1255, SEQ ID NO: 1256, SEQ ID
NO: 1259, SEQ ID NO: 1260, SEQ ID
NO: 1263, SEQ ID NO: 1264, SEQ ID
NO: 1267, SEQ ID NO: 1268, SEQ ID
NO: 1271, SEQ ID NO: 1272, SEQ ID
NO: 1275, SEQ ID NO: 1276, SEQ ID
NO: 1279, SEQ ID NO: 1280, SEQ ID
NO: 1283, SEQ ID NO: 1284, SEQ ID
NO: 1287, SEQ ID NO: 1288, SEQ ID
NO: 1291, SEQ ID NO: 1292, SEQ ID
NO: 1295, SEQ ID NO: 1296, SEQ ID

637

PCT/US98/06956

NO: 1297, SEQ ID NO: 1298, SEQ ID
NO: 1301, SEQ ID NO: 1302, SEQ ID
NO: 1305, SEQ ID NO: 1306, SEQ ID
NO: 1309, SEQ ID NO: 1310, SEQ ID
NO:1313, SEQ ID NO:1314, SEQ ID
NO: 1317, SEQ ID NO:1318, SEQ ID
NO: 1321, SEQ ID NO: 1322, SEQ ID
NO: 1325, SEQ ID NO: 1326, SEQ ID
NO: 1329, SEQ ID NO: 1330, SEQ ID
NO: 1333, SEQ ID NO: 1334, SEQ ID
NO: 1337, SEQ ID NO: 1338, SEQ ID
NO:1341, SEQ ID NO:1342, SEQ ID
NO: 1345, SEQ ID NO: 1346, SEQ ID
NO: 1349, SEQ ID NO: 1350, SEQ ID
NO: 1353, SEQ ID NO: 1354, SEQ ID
NO: 1357, SEQ ID NO: 1358, SEQ ID
NO: 1361, SEQ ID NO: 1362, SEQ ID
NO: 1365, SEQ ID NO: 1366, SEQ ID
NO: 1369, SEQ ID NO: 1370, SEQ ID
NO: 1373, SEQ ID NO: 1374, SEQ ID
NO: 1377, SEQ ID NO: 1378, SEQ ID
NO:1381, SEQ ID NO:1382, SEQ ID
NO: 1385, SEQ ID NO: 1386, SEQ ID
NO: 1389, SEQ ID NO: 1390, SEQ ID
NO: 1393, SEQ ID NO: 1394, SEQ ID
NO: 1397, SEQ ID NO: 1398, SEQ ID
NO: 1401, SEQ ID NO: 1402, SEQ ID
NO: 1405, SEQ ID NO: 1406, SEQ ID
NO: 1409, SEQ ID NO: 1410, SEQ ID
NO: 1413, SEQ ID NO: 1414, SEQ ID
NO: 1417, SEQ ID NO: 1418, SEQ ID
NO: 1421, SEQ ID NO: 1422, SEQ ID
NO: 1425, SEQ ID NO: 1426, SEQ ID
NO: 1429, SEQ ID NO: 1430, SEQ ID

NO: 1299, SEQ ID NO: 1300, SEQ ID
NO: 1303, SEQ ID NO: 1304, SEQ ID
NO: 1307, SEQ ID NO: 1308, SEQ ID
NO:1311, SEQ ID NO:1312, SEQ ID
NO:1315, SEQ ID N0:1316, SEQ ID
NO: 1319, SEQ ID NO: 1320, SEQ ID
NO: 1323, SEQ ID NO: 1324, SEQ ID
NO: 1327, SEQ ID NO: 1328, SEQ ID
NO: 1331, SEQ ID NO: 1332, SEQ ID
NO: 1335, SEQ ID NO: 1336, SEQ ID
NO: 1339, SEQ ID NO: 1340, SEQ ID
NO: 1343, SEQ ID NO: 1344, SEQ ID
NO: 1347, SEQ ID NO: 1348, SEQ ID
NO: 1351, SEQ ID NO: 1352, SEQ ID
NO: 1355, SEQ ID NO: 1356, SEQ ID
NO: 1359, SEQ ID NO: 1360, SEQ ID
NO: 1363, SEQ ID NO: 1364, SEQ ID
NO: 1367, SEQ ID NO: 1368, SEQ ID
NO: 1371, SEQ ID NO: 1372, SEQ ID
NO: 1375, SEQ ID NO: 1376, SEQ ID
NO: 1379, SEQ ID NO: 1380, SEQ ID
NO: 1383, SEQ ID NO: 1384, SEQ ID
NO: 1387, SEQ ID NO: 1388, SEQ ID
NO:1391, SEQ ID NO: 1392, SEQ ID
NO: 1395, SEQ ID NO: 1396, SEQ ID
NO:1399, SEQ ID NO: 1400, SEQ ID
NO: 1403, SEQ ID NO: 1404, SEQ ID
NO: 1407, SEQ ID NO: 1408, SEQ ID
NO: 1411, SEQ ID NO: 1412, SEQ ID
NO:1415, SEQ ID NO: 1416, SEQ ID
NO:1419, SEQ ID NO:1420, SEQ ID
NO: 1423, SEQ ID NO: 1424, SEQ ID
NO: 1427, SEQ ID NO: 1428, SEQ ID
NO: 1431, SEQ ID NO: 1432, SEQ ID

638

ikilHHIIii'iAiiii r iIh

WO 98/45437 PCT/US98/06956

NO: 1433, SEQ ID NO: 1434, SEQ ID NO: 1435, SEQ ID NO: 1436, SEQ ID
NO: 1437, SEQ ID NO: 1438, SEQ ID NO: 1439, SEQ ID NO: 1440, SEQ ID
NO: 1441, SEQ ID NO: 1442, SEQ ID NO: 1443, SEQ ID NO: 1444, SEQ ID
NO: 1445, SEQ ID NO: 1446, SEQ ID NO: 1447, SEQ ID NO: 1448, SEQ ID
NO: 1449, SEQ ID NO: 1450, SEQ ID NO: 1451, SEQ ID NO: 1452, SEQ ID
NO:1453, SEQ ID NO:1454, SEQ ID NO: 1455, SEQ ID NO: 1456, SEQ ID
NO: 1457, SEQ ID NO: 1458, SEQ ID NO: 1459, SEQ ID NO: 1460, SEQ ID
NO: 1461, SEQ ID NO: 1462, SEQ ID NO: 1463, SEQ ID NO: 1464, SEQ ID
NO: 1465, SEQ ID NO: 1466, SEQ ID NO: 1467, SEQ ID NO: 1468, SEQ ID
NO: 1469, SEQ ID NO;1470, SEQ ID NO: 1471, SEQ ID NO:1472, SEQ ID
NO: 1473, SEQ ID NO: 1474, SEQ ID NO: 1475, SEQ ID NO: 1476, SEQ ID
NO: 1477, SEQ ID NO: 1478, SEQ ID NO: 1479, SEQ ID NO: 1480, SEQ ID
NO:1481, SEQ ID NO:1482, SEQ ID NO:1483, SEQ ID NO:1484, SEQ ID
NO: 1485, SEQ ID NO: 1486, SEQ ID NO: 1487, SEQ ID NO: 1488, SEQ ID
NO: 1489, SEQ ID NO: 1490, SEQ ID NO: 1491, SEQ ID NO: 1492, SEQ ID
NO: 1493, SEQ ID NO: 1494, SEQ ID NO: 1495, SEQ ID NO: 1496, SEQ ID
NO: 1497, SEQ ID NO: 1498, SEQ ID NO: 1499, SEQ ID NO: 1500, SEQ ID
NO: 1501, SEQ ID NO: 1502, SEQ ID NO: 1503, SEQ ID NO: 1504, SEQ ID
NO: 1505, SEQ ID NO: 1506, SEQ ID NO: 1507, SEQ ID NO: 1508, SEQ ID
NO: 1509, SEQ ID NO: 15 10, SEQ ID NO: 1511, SEQ ID NO: 15 12, SEQ ID
NO:1513, SEQ ID NO:1514, SEQ ID NO:1515, SEQ ID NO:1516, SEQ ID
NO:1517, SEQ ID NO: 1518, and SEQ ID NO:1519;
or to a complement of said sequence.

5. An isolated protein encoded by an isolated polynucleotide of claim 1 .

6. An isolated protein encoded by an isolated polynucleotide of claim 2,

7. An isolated protein encoded by an isolated polynucleotide of claim 3.

8. An isolated protein encoded by an isolated polynucleotide of claim 4.

639